| Year |
Citation |
Score |
| 2012 |
Gerritz SW, Zhai W, Shi S, Zhu S, Toyn JH, Meredith JE, Iben LG, Burton CR, Albright CF, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Metzler W, Cook LS, ... ... Thompson LA, et al. Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis. Journal of Medicinal Chemistry. 55: 9208-23. PMID 23030502 DOI: 10.1021/Jm300931Y |
0.304 |
|
| 1996 |
Thompson LA, Ellman JA. Synthesis and Applications of Small Molecule Libraries. Chemical Reviews. 96: 555-600. PMID 11848765 DOI: 10.1021/Cr9402081 |
0.415 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2007 |
Yang MG, Shi JL, Modi DP, Wells J, Cochran BM, Wolf MA, Thompson LA, Ramanjulu MM, Roach AH, Zaczek R, Robertson DW, Wexler RR, Olson RE. Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 3910-5. PMID 17502143 DOI: 10.1016/j.bmcl.2007.04.102 |
0.289 |
|
| 2000 |
Thompson LA. Recent applications of polymer-supported reagents and scavengers in combinatorial, parallel, or multistep synthesis. Current Opinion in Chemical Biology. 4: 324-37. PMID 10826975 DOI: 10.1016/S1367-5931(00)00096-X |
0.273 |
|
| 2006 |
Thompson LA, Liauw AY, Ramanjulu MM, Kasireddy-Polam P, Mercer SE, Maduskuie TP, Glicksman M, Roach AH, Meredith JE, Liu RQ, Combs AP, Higaki JN, Cordell B, Seiffert D, Zaczek RC, et al. Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 2357-63. PMID 16473009 DOI: 10.1016/j.bmcl.2006.01.055 |
0.26 |
|
| 2009 |
Wu YJ, Zhang Y, Good AC, Burton CR, Toyn JH, Albright CF, Macor JE, Thompson LA. Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE. Bioorganic & Medicinal Chemistry Letters. 19: 2654-60. PMID 19375914 DOI: 10.1016/J.Bmcl.2009.03.144 |
0.249 |
|
| 2011 |
Marcin LR, Higgins MA, Zusi FC, Zhang Y, Dee MF, Parker MF, Muckelbauer JK, Camac DM, Morin PE, Ramamurthy V, Tebben AJ, Lentz KA, Grace JE, Marcinkeviciene JA, Kopcho LM, ... ... Thompson LA, et al. Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1. Bioorganic & Medicinal Chemistry Letters. 21: 537-41. PMID 21078556 DOI: 10.1016/J.Bmcl.2010.10.079 |
0.245 |
|
| 2002 |
Marcinkeviciene J, Kopcho LM, Yang T, Copeland RA, Glass BM, Combs AP, Falahatpisheh N, Thompson L. Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers. The Journal of Biological Chemistry. 277: 28677-82. PMID 12029090 DOI: 10.1074/jbc.M203120200 |
0.24 |
|
| 2011 |
Boy KM, Guernon JM, Shi J, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Marcinkeviciene J, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Lentz KA, Bronson JJ, ... ... Thompson LA, et al. Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE). Bioorganic & Medicinal Chemistry Letters. 21: 6916-24. PMID 21782431 DOI: 10.1016/J.Bmcl.2011.06.109 |
0.235 |
|
| 2011 |
Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, et al. Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 6909-15. PMID 21974952 DOI: 10.1016/J.Bmcl.2011.06.116 |
0.224 |
|
| 2016 |
Wu YJ, Zhang Y, Toyn JH, Macor JE, Thompson LA. Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators. Bioorganic & Medicinal Chemistry Letters. PMID 26898338 DOI: 10.1016/j.bmcl.2016.02.016 |
0.205 |
|
| 2018 |
Wu YJ, Guernon J, McClure A, Venables B, Rajamani R, Robbins KJ, Knox RJ, Matchett M, Pieschl RL, Herrington J, Bristow LJ, Meanwell NA, Olson R, Thompson LA, Dzierba C. Discovery of morpholine-based aryl sulfonamides as Na1.7 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29439904 DOI: 10.1016/J.Bmcl.2018.01.035 |
0.203 |
|
| 2018 |
Wu YJ, Venables B, Guernon J, Chen J, Sit SY, Rajamani R, Knox RJ, Matchett M, Pieschl RL, Herrington J, Bristow LJ, Meanwell NA, Thompson LA, Dzierba C. Discovery of new indole-based acylsulfonamide Na1.7 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30638874 DOI: 10.1016/J.Bmcl.2018.12.013 |
0.198 |
|
| 2016 |
Wu YJ, Guernon J, Rajamani R, Toyn JH, Ahlijanian MK, Albright CF, Muckelbauer J, Chang C, Camac D, Macor JE, Thompson LA. Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27816517 DOI: 10.1016/J.Bmcl.2016.10.055 |
0.197 |
|
| 2015 |
Boy KM, Guernon JM, Wu YJ, Zhang Y, Shi J, Zhai W, Zhu S, Gerritz SW, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Good AC, Grace JE, ... ... Thompson LA, et al. Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE). Bioorganic & Medicinal Chemistry Letters. PMID 26497283 DOI: 10.1016/J.Bmcl.2015.10.031 |
0.194 |
|
| 2016 |
Wu YJ, Guernon J, Park H, Thompson LA. An Expedient Synthesis of Furo[2,3-d][1,3]thiazinamines and Pyrano[2,3-d][1,3]thiazinamines from Enones and Thiourea. The Journal of Organic Chemistry. PMID 27002691 DOI: 10.1021/acs.joc.5b02705 |
0.185 |
|
| 2008 |
Iben LG, Kopcho L, Marcinkeviciene J, Zheng C, Thompson LA, Albright CF, Toyn JH. [3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors. European Journal of Pharmacology. 593: 10-5. PMID 18655784 DOI: 10.1016/J.Ejphar.2008.06.112 |
0.161 |
|
| 1999 |
Dragoli DR, Thompson LA, O'Brien J, Ellman JA. Parallel synthesis of prostaglandin E1 analogues. Journal of Combinatorial Chemistry. 1: 534-9. PMID 10748730 DOI: 10.1021/Cc990033E |
0.159 |
|
| 2016 |
Wu YJ, Guernon J, Shi J, Marcin L, Higgins M, Rajamani R, Muckelbauer JK, Lewis HA, Chang C, Camac D, Toyn JH, Ahlijanian MK, Albright CF, Macor JE, Thompson LA. Discovery of S3-truncated, C-6 heteroaryl substituted aminothiazine β-site APP cleaving enzyme-1 (BACE1) inhibitors. Journal of Medicinal Chemistry. PMID 27559936 DOI: 10.1021/Acs.Jmedchem.6B01012 |
0.155 |
|
| 2017 |
Bristow LJ, Gulia J, Weed MR, Srikumar BN, Li YW, Graef JD, Naidu PS, Sanmathi C, Aher J, Bastia T, Paschapur M, Kalidindi N, Kumar KV, Molski T, Pieschl R, ... ... Thompson LA, et al. Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-D-Aspartate 2B (GluN2B) Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder. The Journal of Pharmacology and Experimental Therapeutics. PMID 28954811 DOI: 10.1124/jpet.117.242784 |
0.154 |
|
| 2003 |
Voss ME, Carter PH, Tebben AJ, Scherle PA, Brown GD, Thompson LA, Xu M, Lo YC, Yang G, Liu RQ, Strzemienski P, Everlof JG, Trzaskos JM, Decicco CP. Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists. Bioorganic & Medicinal Chemistry Letters. 13: 533-8. PMID 12565966 DOI: 10.1016/S0960-894X(02)00941-1 |
0.137 |
|
| 2017 |
Wu YJ, Guernon J, McClure A, Luo G, Rajamani R, Ng A, Easton A, Newton A, Bourin C, Parker D, Mosure K, Barnaby O, Soars MG, Knox RJ, Matchett M, ... ... Thompson LA, et al. Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation. Bioorganic & Medicinal Chemistry. PMID 28818462 DOI: 10.1016/J.Bmc.2017.08.012 |
0.137 |
|
| 2020 |
Zhang Y, Boy KM, Wu YJ, Ramirez A, Toyn JH, Ahlijanian MK, Albright CF, Zhuo X, Johnson BM, Denton RR, Olson RE, Thompson LA, Macor JE. Synthesis of Functionalized Derivatives of the Gamma-Secretase Modulator BMS-932481 and Identification of its Major Metabolite. Bioorganic & Medicinal Chemistry Letters. 127530. PMID 32890687 DOI: 10.1016/J.Bmcl.2020.127530 |
0.133 |
|
| 2017 |
Robertson AS, Iben LG, Wei C, Meredith JE, Drexler DM, Banks M, Vite GD, Olson RE, Thompson LA, Albright CF, Ahlijanian MK, Toyn JH. Synergistic inhibition of Aβ production by combinations of γ-secretase modulators. European Journal of Pharmacology. PMID 28690193 DOI: 10.1016/J.Ejphar.2017.07.019 |
0.132 |
|
| 2018 |
Luo G, Chen L, Easton A, Newton A, Bourin C, Shields E, Mosure K, Soars MG, Knox RJ, Matchett M, Pieschl RL, Post-Munson D, Wang S, Herrington J, Graef J, ... ... Thompson LA, et al. Discovery of Indole- and Indazole-Acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 30576602 DOI: 10.1021/Acs.Jmedchem.8B01550 |
0.127 |
|
| 2017 |
Wu YJ, Guernon J, Shi J, Ditta J, Robbins KJ, Rajamani R, Easton A, Newton AE, Bourin C, Mosure K, Soars MG, Knox RJ, Matchett M, Pieschl RL, Post-Munson DJ, ... ... Thompson LA, et al. Development of new benzenesulfonamides as potent and selective Nav1.7 inhibitors for the treatment of pain. Journal of Medicinal Chemistry. PMID 28234467 DOI: 10.1021/Acs.Jmedchem.6B01918 |
0.126 |
|
| 2016 |
Wu YJ, Guernon J, Yang F, Snyder L, Shi J, Mcclure A, Rajamani R, Park H, Ng A, Lewis H, Chang C, Camac D, Toyn JH, Ahlijanian MK, Albright CF, ... ... Thompson LA, et al. Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents. Acs Medicinal Chemistry Letters. 7: 271-6. PMID 26985314 DOI: 10.1021/Acsmedchemlett.5B00432 |
0.125 |
|
| 2018 |
Marcin LR, Warrier J, Thangathirupathy S, Shi J, Karageorge GN, Pearce BC, Ng A, Park H, Kempson J, Li J, Zhang H, Mathur A, Reddy AB, Nagaraju G, Tonukunuru G, ... ... Thompson LA, et al. BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder. Acs Medicinal Chemistry Letters. 9: 472-477. PMID 29795762 DOI: 10.1021/acsmedchemlett.8b00080 |
0.119 |
|
| 2005 |
Thompson LA, Bronson JJ, Zusi FC. Progress in the discovery of BACE inhibitors. Current Pharmaceutical Design. 11: 3383-404. PMID 16250843 DOI: 10.2174/138161205774370825 |
0.118 |
|
| 2015 |
Thakker DR, Sankaranarayanan S, Weatherspoon MR, Harrison J, Pierdomenico M, Heisel JM, Thompson LA, Haskell R, Grace JE, Taylor SJ, Albright CF, Shafer LL. Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6931-6. PMID 25926467 DOI: 10.1523/Jneurosci.2262-14.2015 |
0.118 |
|
| 2016 |
Toyn JH, Boy KM, Raybon J, Meredith JE, Roberston AS, Guss V, Hoque N, Sweeney F, Zhuo X, Clarke W, Snow K, Denton RR, Zuev D, Thompson LA, Morrison J, et al. Robust translation of GSM pharmacology across preclinical species and human subjects. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189974 DOI: 10.1124/Jpet.116.232249 |
0.118 |
|
| 2003 |
Kopcho LM, Ma J, Marcinkeviciene J, Lai Z, Witmer MR, Cheng J, Yanchunas J, Tredup J, Corbett M, Calambur D, Wittekind M, Paruchuri M, Kothari D, Lee G, Ganguly S, ... ... Thompson LA, et al. Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme. Archives of Biochemistry and Biophysics. 410: 307-16. PMID 12573291 DOI: 10.1016/S0003-9861(02)00690-2 |
0.112 |
|
| 2015 |
Shi J, Zuev D, Xu L, Lentz KA, Grace JE, Toyn JH, Olson RE, Macor JE, Thompson LA. Design and optimization of tricyclic gamma-secretase modulators. Bioorganic & Medicinal Chemistry Letters. PMID 26848108 DOI: 10.1016/J.Bmcl.2015.06.020 |
0.109 |
|
| 2002 |
Berechid BE, Kitzmann M, Foltz DR, Roach AH, Seiffert D, Thompson LA, Olson RE, Bernstein A, Donoviel DB, Nye JS. Identification and characterization of presenilin-independent Notch signaling. The Journal of Biological Chemistry. 277: 8154-65. PMID 11756438 DOI: 10.1074/jbc.M108238200 |
0.109 |
|
| 2019 |
Boy KM, Guernon JM, Zuev DS, Xu L, Zhang Y, Shi J, Marcin LR, Higgins MA, Wu YJ, Krishnananthan S, Li J, Trehan A, Smith D, Toyn JH, Meredith JE, ... ... Thompson LA, et al. Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481. Acs Medicinal Chemistry Letters. 10: 312-317. PMID 30891132 DOI: 10.1021/Acsmedchemlett.8B00541 |
0.097 |
|
| 2020 |
Rojas LA, Valentine E, Accorsi A, Maglio J, Shen N, Robertson A, Kazmirski S, Rahl P, Tawil R, Cadavid D, Thompson LA, Ronco L, Chang A, Cacace A, Wallace O. P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular Dystrophy. The Journal of Pharmacology and Experimental Therapeutics. PMID 32576599 DOI: 10.1124/Jpet.119.264689 |
0.093 |
|
| 2008 |
Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, et al. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice. The Journal of Pharmacology and Experimental Therapeutics. 326: 502-13. PMID 18499745 DOI: 10.1124/Jpet.108.138974 |
0.076 |
|
| 2016 |
Soares HD, Gasior M, Toyn JH, Wang JS, Hong Q, Berisha F, Furlong MT, Raybon J, Lentz KA, Sweeney F, Zheng N, Akinsanya B, Berman RM, Thompson LA, Olson RE, et al. The Gamma Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and CSF of Healthy Volunteers. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189973 DOI: 10.1124/Jpet.116.232256 |
0.071 |
|
| 2014 |
Toyn JH, Thompson LA, Lentz KA, Meredith JE, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, et al. Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780. International Journal of Alzheimer's Disease. 2014: 431858. PMID 25097793 DOI: 10.1155/2014/431858 |
0.068 |
|
| 2002 |
Blat Y, Meredith JE, Wang Q, Bradley JD, Thompson LA, Olson RE, Stern AM, Seiffert D. Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase. Biochemical and Biophysical Research Communications. 299: 569-73. PMID 12459176 DOI: 10.1016/S0006-291X(02)02705-5 |
0.065 |
|
| 2019 |
Luo G, Chen L, Easton A, Newton A, Bourin C, Shields E, Mosure K, Soars MG, Knox RJ, Matchett M, Pieschl RL, Post-Munson DJ, Wang S, Herrington J, Graef J, ... ... Thompson LA, et al. Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na1.7 Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 30734560 DOI: 10.1021/Acs.Jmedchem.9B00202 |
0.056 |
|
| 2014 |
Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S. The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. Acta Crystallographica. Section F, Structural Biology Communications. 70: 173-81. PMID 24637750 DOI: 10.1107/S2053230X14000144 |
0.046 |
|
| 1928 |
Thompson LA, Remmers HH. Some observations concerning the reliability of the Pressey X-O test Journal of Applied Psychology. 12: 477-494. DOI: 10.1037/h0075647 |
0.034 |
|
| 2021 |
Mellion ML, Ronco L, Berends CL, Pagan L, Brooks S, van Esdonk MJ, van Brummelen EMJ, Odueyungbo A, Thompson LA, Hage M, Badrising UA, Raines S, Tracewell WG, van Engelen B, Cadavid D, et al. Phase 1 Clinical Trial of Losmapimod in Facioscapulohumeral Dystrophy (FSHD): Safety, Tolerability, Pharmacokinetics, and Target Engagement. British Journal of Clinical Pharmacology. PMID 33931884 DOI: 10.1111/bcp.14884 |
0.031 |
|
| 1980 |
Tarenghi M, Chincarini G, Rood HJ, Thompson LA. The Hercules supercluster. II - Analysis The Astrophysical Journal. 235: 724. DOI: 10.1086/157675 |
0.01 |
|
| 1975 |
Jacobs M, Thompson LA, Truxaw P. The Use of Sexual Surrogates in Counseling The Counseling Psychologist. 5: 73-77. DOI: 10.1177/001100007500500118 |
0.01 |
|
| 1925 |
Remmers HH, Thompson LA. A note on motor activity as conditioned by emotional states Journal of Applied Psychology. 9: 417-423. DOI: 10.1037/h0075775 |
0.01 |
|
| Hide low-probability matches. |