Jeffrey Clifton Watkins, PhD - Publications

Affiliations: 
Pharmacology University of Bristol, Bristol, England, United Kingdom 
Area:
Glutamate pharmacology and medicinal chemistry

139 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Jane DE, Olverman HJ, Watkins JC. Agonists and competitive antagonists: Structure-activity and molecular modelling studies The Nmda Receptor. DOI: 10.1093/acprof:oso/9780192625021.003.0002  0.4
2012 Watkins JC. The NMDA receptor concept: Origins and development The Nmda Receptor. DOI: 10.1093/acprof:oso/9780192625021.003.0001  0.4
2012 Collingridge GL, Watkins JC. The NMDA Receptor The Nmda Receptor. 1-518. DOI: 10.1093/acprof:oso/9780192625021.001.0001  0.4
2012 Collingridge GL, Watkins JC. Preface The Nmda Receptor 0.4
2006 Watkins JC, Jane DE. The glutamate story. British Journal of Pharmacology. 147: S100-8. PMID 16402093 DOI: 10.1038/sj.bjp.0706444  1
2002 Knapp RJ, Goldenberg R, Shuck C, Cecil A, Watkins J, Miller C, Crites G, Malatynska E. Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model. European Journal of Pharmacology. 440: 27-35. PMID 11959085 DOI: 10.1016/S0014-2999(02)01338-9  1
2000 Watkins JC. l-glutamate as a central neurotransmitter: looking back. Biochemical Society Transactions. 28: 297-309. PMID 10961913  1
1998 Brown JC, Tse HW, Skifter DA, Christie JM, Andaloro VJ, Kemp MC, Watkins JC, Jane DE, Monaghan DT. [3H]homoquinolinate binds to a subpopulation of NMDA receptors and to a novel binding site. Journal of Neurochemistry. 71: 1464-70. PMID 9751179  1
1997 Wilson C, Howard JA, Jane DE, Sunter DC, Watkins JC. Absolute configuration of (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist. Acta Crystallographica. Section C, Crystal Structure Communications. 53: 909-11. PMID 9241811  1
1997 Thoreson WB, Gottesman J, Jane DE, Tse HW, Watkins JC, Miller RF. Two phenylglycine derivatives antagonize responses to L-AP4 in ON bipolar cells of the amphibian retina. Neuropharmacology. 36: 13-20. PMID 9144637 DOI: 10.1016/S0028-3908(96)00164-5  1
1997 Curtis DR, Phillis JW, Watkins JC. Actions of amino-acids on the isolated hemisected spinal cord of the toad. 1961. British Journal of Pharmacology. 120: 204-25; discussion 2. PMID 9142407  1
1997 Wilson C, Howard JAK, Jane DE, Sunter DC, Watkins JC. Absolute configuration of (+)-α-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist Acta Crystallographica Section C: Crystal Structure Communications. 53: 909-911.  1
1996 Jane DE, Thomas NK, Tse HW, Watkins JC. Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology. 35: 1029-35. PMID 9121605 DOI: 10.1016/S0028-3908(96)00048-2  1
1996 Jane DE, Chalmers DJ, Howard JA, Kilpatrick IC, Sunter DC, Thompson GA, Udvarhelyi PM, Wilson C, Watkins JC. Diastereoselective synthesis of all four isomers of 3-(4-chlorophenyl) glutamic acid: identification of the isomers responsible for the potentiation of L-homocysteic acid-evoked depolarizations in neonatal rat motoneurons. Journal of Medicinal Chemistry. 39: 4738-43. PMID 8941386 DOI: 10.1021/jm960382c  1
1996 Thomas NK, Jane DE, Tse HW, Watkins JC. alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology. 35: 637-42. PMID 8887973 DOI: 10.1016/S0028-3908(96)00019-6  1
1996 Sekiyama N, Hayashi Y, Nakanishi S, Jane DE, Tse HW, Birse EF, Watkins JC. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. British Journal of Pharmacology. 117: 1493-503. PMID 8730745  1
1996 Bushell TJ, Jane DE, Tse HW, Watkins JC, Garthwaite J, Collingridge GL. Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. British Journal of Pharmacology. 117: 1457-62. PMID 8730739  1
1995 Chalmers DJ, Jane DE, Sunter DC, Thompson GA, Udvarhelyi PM, Kilpatrick IC, Watkins JC. Differential actions of 3-(4-chlorophenyl) glutamic acid stereoisomers and L-trans-pyrrolidine-2,4-dicarboxylic acid upon L-homocysteic acid- and L-glutamic acid-induced responses from rat spinal motoneurones. Neuropharmacology. 34: 1589-95. PMID 8788956 DOI: 10.1016/0028-3908(95)00124-7  1
1995 Bedingfield JS, Kemp MC, Jane DE, Tse HW, Roberts PJ, Watkins JC. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). British Journal of Pharmacology. 116: 3323-9. PMID 8719814  1
1995 Attwell PJ, Kaura S, Sigala G, Bradford HF, Croucher MJ, Jane DE, Watkins JC. Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist. Brain Research. 698: 155-62. PMID 8581475 DOI: 10.1016/0006-8993(95)00886-U  1
1995 Vignes M, Clarke VR, Davies CH, Chambers A, Jane DE, Watkins JC, Collingridge GL. Pharmacological evidence for an involvement of group II and group III mGluRs in the presynaptic regulation of excitatory synaptic responses in the CA1 region of rat hippocampal slices. Neuropharmacology. 34: 973-82. PMID 8532178 DOI: 10.1016/0028-3908(95)00093-L  1
1995 Jane DE, Pittaway K, Sunter DC, Thomas NK, Watkins JC. New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology. 34: 851-6. PMID 8532166 DOI: 10.1016/0028-3908(95)00063-C  1
1995 Bushell TJ, Jane DE, Tse HW, Watkins JC, Davies CH, Garthwaite J, Collingridge GL. Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4. Neuropharmacology. 34: 239-41. PMID 7617150 DOI: 10.1016/0028-3908(95)00012-U  1
1994 Hayashi Y, Sekiyama N, Nakanishi S, Jane DE, Sunter DC, Birse EF, Udvarhelyi PM, Watkins JC. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3370-7. PMID 8182479  1
1994 Kemp M, Roberts P, Pook P, Jane D, Jones A, Jones P, Sunter D, Udvarhelyi P, Watkins J. Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors European Journal of Pharmacology: Molecular Pharmacology. 266: 187-192. PMID 8157072 DOI: 10.1016/0922-4106(94)90109-0  1
1994 Gaoni Y, Chapman AG, Parvez N, Pook PC, Jane DE, Watkins JC. Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives. Journal of Medicinal Chemistry. 37: 4288-96. PMID 7996540  1
1994 Watkins JC, Collingridge GL. Phenylglycine derivatives as antagonists of metabotropic glutamate receptors Trends in Pharmacological Sciences. 15: 333-342. PMID 7992387 DOI: 10.1016/0165-6147(94)90028-0  1
1994 Jane DE, Jones PL, Pook PC, Tse HW, Watkins JC. Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord. British Journal of Pharmacology. 112: 809-16. PMID 7921606  1
1994 Wong LA, Mayer ML, Jane DE, Watkins JC. Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3881-97. PMID 7515954  1
1993 Bashir ZI, Bortolotto ZA, Davies CH, Berretta N, Irving AJ, Seal AJ, Henley JM, Jane DE, Watkins JC, Collingridge GL. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature. 363: 347-50. PMID 8388549 DOI: 10.1038/363347a0  1
1993 Eaton SA, Jane DE, Jones PL, Porter RH, Pook PC, Sunter DC, Udvarhelyi PM, Roberts PJ, Salt TE, Watkins JC. Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. European Journal of Pharmacology. 244: 195-7. PMID 8381746 DOI: 10.1016/0922-4106(93)90028-8  1
1993 Eaton SA, Birse EF, Wharton B, Sunter DC, Udvarhelyi PM, Watkins JC, Salt TE. Mediation of thalamic sensory responses in vivo by ACPD-activated excitatory amino acid receptors. The European Journal of Neuroscience. 5: 186-9. PMID 8261098  1
1993 Bashir ZI, Jane DE, Sunter DC, Watkins JC, Collingridge GL. Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus. European Journal of Pharmacology. 239: 265-6. PMID 8223907 DOI: 10.1016/0014-2999(93)91009-C  1
1993 Pook P, Brugger F, Hawkins NS, Clark KC, Watkins JC, Evans RH. A comparison of the actions of agonists and antagonists at non-NMDA receptors of C fibres and motoneurones of the immature rat spinal cord in vitro. British Journal of Pharmacology. 108: 179-84. PMID 8094024 DOI: 10.1111/j.1476-5381.1993.tb13459.x  1
1993 Kaura S, Croucher MJ, Bradford HF, Sunter DC, Watkins JC. Relative anticonvulsant potencies of CPP and some novel analogues in the kindled rat. Biochemical Society Transactions. 21: 419S. PMID 7907558  1
1993 Jane DE, Jones PL, Pook PC, Salt TE, Sunter DC, Watkins JC. Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology. 32: 725-7. PMID 7689710 DOI: 10.1016/0028-3908(93)90088-K  1
1993 Birse EF, Eaton SA, Jane DE, Jones PL, Porter RH, Pook PC, Sunter DC, Udvarhelyi PM, Wharton B, Roberts PJ. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience. 52: 481-8. PMID 7680790 DOI: 10.1016/0306-4522(93)90400-A  1
1993 Glaum SR, Sunter DC, Udvarhelyi PM, Watkins JC, Miller RJ. The actions of phenylglycine derived metabotropic glutamate receptor antagonists on multiple (1S,3R)-ACPD responses in the rat nucleus of the tractus solitarius. Neuropharmacology. 32: 1419-25. PMID 7512236 DOI: 10.1016/0028-3908(93)90039-6  1
1992 Pook PC, Sunter DC, Udvarhelyi PM, Watkins JC. Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)- and (1S,3R)-ACPD. Experimental Physiology. 77: 529-32. PMID 1632963  1
1992 Patneau DK, Mayer ML, Jane DE, Watkins JC. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 595-606. PMID 1371315  1
1992 Porter RH, Roberts PJ, Jane DE, Watkins JC. (S)-homoquisqualate: a potent agonist at the glutamate metabotropic receptor. British Journal of Pharmacology. 106: 509-10. PMID 1324071  1
1991 Watkins JC. Some chemical highlights in the development of excitatory amino acid pharmacology. Canadian Journal of Physiology and Pharmacology. 69: 1064-75. PMID 1954563  1
1990 Irving AJ, Schofield JG, Watkins JC, Sunter DC, Collingridge GL. 1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons. European Journal of Pharmacology. 186: 363-5. PMID 2289537 DOI: 10.1016/0014-2999(90)90462-F  1
1990 Udvarhelyi PM, Watkins JC. Direct resolution of some phenylglycines by liquid chromatography on a chiral crown ether phase. Chirality. 2: 200-4. PMID 2252846 DOI: 10.1002/chir.530020313  1
1990 Watkins JC, Krogsgaard-Larsen P, Honoré T. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends in Pharmacological Sciences. 11: 25-33. PMID 2155495 DOI: 10.1016/0165-6147(90)90038-A  1
1990 Udvarhelyi PM, Sunter DC, Watkins JC. Direct separation of amino acid enantiomers using a chiral crown ether stationary phase. Application to 2-amino-omega-phosphonoalkanoic acids. Journal of Chromatography. 519: 69-74. PMID 2150201 DOI: 10.1016/0021-9673(90)85135-I  1
1990 Watkins JC, Pook PC, Sunter DC, Davies J, Honore T. Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Advances in Experimental Medicine and Biology. 268: 49-55. PMID 1963751  1
1989 Honoré T, Drejer J, Nielsen EO, Watkins JC, Olverman HJ, Nielsen M. Molecular target size analyses of the NMDA-receptor complex in rat cortex. European Journal of Pharmacology. 172: 239-47. PMID 2550262 DOI: 10.1016/0922-4106(89)90054-0  1
1989 Aebischer B, Frey P, Haerter HP, Herrling PL, Mueller W, Olverman HJ, Watkins JC. Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (CPP-ene) Helvetica Chimica Acta. 72: 1043-1051.  1
1988 Croucher MJ, Bradford HF, Sunter DC, Watkins JC. Inhibition of the development of electrical kindling of the prepyriform cortex by daily focal injections of excitatory amino acid antagonists. European Journal of Pharmacology. 152: 29-38. PMID 3208834 DOI: 10.1016/0014-2999(88)90832-1  1
1988 Monaghan DT, Olverman HJ, Nguyen L, Watkins JC, Cotman CW. Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine. Proceedings of the National Academy of Sciences of the United States of America. 85: 9836-40. PMID 2904680  1
1988 Olverman HJ, Jones AW, Mewett KN, Watkins JC. Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes. Neuroscience. 26: 17-31. PMID 2901691 DOI: 10.1016/0306-4522(88)90124-8  1
1988 Olverman HJ, Jones AW, Watkins JC. [3H]D-2-amino-5-phosphonopentanoate as a ligand for N-methyl-D-aspartate receptors in the mammalian central nervous system. Neuroscience. 26: 1-15. PMID 2901689 DOI: 10.1016/0306-4522(88)90123-6  1
1988 Bridges RJ, Kadri MM, Monaghan DT, Nunn PB, Watkins JC, Cotman CW. Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. European Journal of Pharmacology. 145: 357-9. PMID 2895006 DOI: 10.1016/0014-2999(88)90442-6  1
1988 Childs AM, Evans RH, Watkins JC. The pharmacological selectivity of three NMDA antagonists. European Journal of Pharmacology. 145: 81-6. PMID 2894999 DOI: 10.1016/0014-2999(88)90352-4  1
1987 Chapman AG, Meldrum BS, Nanji N, Watkins JC. Anticonvulsant action and biochemical effects in DBA/2 mice of CPP (3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonate), a novel N-methyl-D-aspartate antagonist. European Journal of Pharmacology. 139: 91-6. PMID 3308490 DOI: 10.1016/0014-2999(87)90501-2  1
1987 Turski L, Meldrum BS, Turski WA, Watkins JC. Evidence that antagonism at non-NMDA receptors results in anticonvulsant action. European Journal of Pharmacology. 136: 69-73. PMID 3036544 DOI: 10.1016/0014-2999(87)90780-1  1
1987 Honoré T, Drejer J, Nielsen M, Watkins JC, Olverman HJ. Molecular target size of NMDA antagonist binding sites. European Journal of Pharmacology. 136: 137-8. PMID 3036542 DOI: 10.1016/0014-2999(87)90793-X  1
1987 Turski L, Klockgether T, Sontag KH, Herrling PL, Watkins JC. Muscle relaxant and anticonvulsant activity of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel N-methyl-D-aspartate antagonist, in rodents. Neuroscience Letters. 73: 143-8. PMID 3029636 DOI: 10.1016/0304-3940(87)90008-5  1
1987 Watkins JC, Olverman HJ. Agonists and antagonists for excitatory amino acid receptors Trends in Neurosciences. 10: 265-272. DOI: 10.1016/0166-2236(87)90171-8  1
1986 Olverman HJ, Monaghan DT, Cotman CW, Watkins JC. [3H]CPP, a new competitive ligand for NMDA receptors. European Journal of Pharmacology. 131: 161-2. PMID 3028828 DOI: 10.1016/0014-2999(86)90533-9  1
1986 Ganong AH, Jones AW, Watkins JC, Cotman CW. Parallel antagonism of synaptic transmission and kainate/quisqualate responses in the hippocampus by piperazine-2,3-dicarboxylic acid analogs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 6: 930-7. PMID 3009733  1
1986 Harris EW, Ganong AH, Monaghan DT, Watkins JC, Cotman CW. Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus. Brain Research. 382: 174-7. PMID 2876750 DOI: 10.1016/0006-8993(86)90128-9  1
1986 Davies J, Evans RH, Herrling PL, Jones AW, Olverman HJ, Pook P, Watkins JC. CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity. Brain Research. 382: 169-73. PMID 2876749 DOI: 10.1016/0006-8993(86)90127-7  1
1985 Chapman AG, Hart GP, Meldrum BS, Turski L, Watkins JC. Anticonvulsant activity of two novel piperazine derivatives with potent kainate antagonist activity. Neuroscience Letters. 55: 325-30. PMID 3892372 DOI: 10.1016/0304-3940(85)90456-2  1
1985 Davies J, Francis AA, Oakes DJ, Sheardown MJ, Watkins JC. Selective potentiating effect of beta-p-chlorophenylglutamate on responses induced by certain sulphur-containing excitatory amino acids and quisqualate. Neuropharmacology. 24: 177-80. PMID 3887200 DOI: 10.1016/0028-3908(85)90178-9  1
1985 Davies J, Watkins JC. Depressant actions of gamma-D-glutamylaminomethyl sulfonate (GAMS) on amino acid-induced and synaptic excitation in the cat spinal cord. Brain Research. 327: 113-20. PMID 3838689 DOI: 10.1016/0006-8993(85)91505-7  1
1985 Turski L, Meldrum BS, Jones AW, Watkins JC. Anticonvulsant action of stereoisomers of gamma-glutamylaminomethylsulphonic acid in mice. European Journal of Pharmacology. 111: 279-83. PMID 2990954 DOI: 10.1016/0014-2999(85)90769-1  1
1984 Jones AW, Smith DA, Watkins JC. Structure-activity relations of dipeptide antagonists of excitatory amino acids. Neuroscience. 13: 573-81. PMID 6392929 DOI: 10.1016/0306-4522(84)90250-1  1
1984 Monaghan DT, Yao D, Olverman HJ, Watkins JC, Cotman CW. Autoradiography of D-2-[3H]amino-5-phosphonopentanoate binding sites in rat brain. Neuroscience Letters. 52: 253-8. PMID 6151632 DOI: 10.1016/0304-3940(84)90170-8  1
1984 Jones AW, Croucher MJ, Meldrum BS, Watkins JC. Suppression of audiogenic seizures in DBA/2 mice by two new dipeptide NMDA receptor antagonists. Neuroscience Letters. 45: 157-61. PMID 6145126 DOI: 10.1016/0304-3940(84)90092-2  1
1984 Olverman HJ, Jones AW, Watkins JC. L-glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes. Nature. 307: 460-2. PMID 6141527 DOI: 10.1038/307460a0  1
1984 Davies J, Jones AW, Sheardown MJ, Smith DA, Watkins JC. Phosphono dipeptides and piperazine derivatives as antagonists of amino acid-induced and synaptic excitation in mammalian and amphibian spinal cord. Neuroscience Letters. 52: 79-84. PMID 6098881 DOI: 10.1016/0304-3940(84)90354-9  1
1984 Croucher MJ, Meldrum BS, Jones AW, Watkins JC. gamma-D-Glutamylaminomethylsulphonic acid (GAMS), a kainate and quisqualate antagonist, prevents sound-induced seizures in DBA/2 mice. Brain Research. 322: 111-4. PMID 6097331 DOI: 10.1016/0006-8993(84)91186-7  1
1984 Watkins JC. Excitatory amino acids and central synaptic transmission Trends in Pharmacological Sciences. 5: 373-376. DOI: 10.1016/0165-6147(84)90474-7  1
1983 Mewett KN, Oakes DJ, Olverman HJ, Smith DA, Watkins JC. Pharmacology of the excitatory actions of sulphonic and sulphinic amino acids. Advances in Biochemical Psychopharmacology. 37: 163-74. PMID 6314755  1
1983 Davies J, Watkins JC. Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord. Experimental Brain Research. 49: 280-90. PMID 6131834 DOI: 10.1007/BF00238587  1
1982 Watkins J, Dargie HJ, Brown MJ, Krikler DM, Dollery CT. Effects of histamine type 2 receptor stimulation on myocardial function in normal subjects. British Heart Journal. 47: 539-45. PMID 7082501  1
1982 Evans RH, Francis AA, Jones AW, Smith DA, Watkins JC. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. British Journal of Pharmacology. 75: 65-75. PMID 7042024  1
1982 Davies J, Evans RH, Francis AA, Jones AW, Smith DA, Watkins JC. Conformational aspects of the actions of some piperidine dicarboxylic acids at excitatory amino acid receptors in the mammalian and amphibian spinal cord. Neurochemical Research. 7: 1119-33. PMID 6294543 DOI: 10.1007/BF00964890  1
1982 Davies J, Watkins JC. Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Research. 235: 378-86. PMID 6145492 DOI: 10.1016/0006-8993(82)91017-4  1
1982 Davies J, Evans RH, Jones AW, Smith DA, Watkins JC. Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous systems. Comparative Biochemistry and Physiology. C: Comparative Pharmacology. 72: 211-24. PMID 6128141 DOI: 10.1016/0306-4492(82)90086-7  1
1982 Davies J, Watkins JC. Selective excitatory amino acid antagonist action of γ-D-glutamyl-aminomethyl-sulphonate (GAMS) on cat spinal neurones Journal of Physiology. 108P-109P.  1
1981 Davies J, Watkins JC. Pharmacology of glutamate and aspartate antagonists on cat spinal neurones. Advances in Biochemical Psychopharmacology. 27: 275-84. PMID 7446276  1
1981 Davies J, Evans RH, Francis AA, Jones AW, Watkins JC. Antagonism of excitatory amino acid-induced and synaptic excitation of spinal neurones by cis-2,3-piperidine dicarboxylate. Journal of Neurochemistry. 36: 1305-7. PMID 7009789 DOI: 10.1111/j.1471-4159.1981.tb01736.x  1
1981 Davies J, Watkins JC. Differentiation of kainate and quisqualate receptors in the cat spinal cord by selective antagonism with gamma-D(and L)-glutamylglycine. Brain Research. 206: 172-7. PMID 6258721 DOI: 10.1016/0006-8993(81)90111-6  1
1981 FitzGerald GA, Watkins J, Dollery CT. Regulation of norepinephrine release by peripheral α2-receptor stimulation Clinical Pharmacology and Therapeutics. 29: 160-167. PMID 6257444  1
1981 Watkins JC. Pharmacology of excitatory amino acid transmitters. Advances in Biochemical Psychopharmacology. 29: 205-12. PMID 6114621  1
1981 Evans RH, Watkins JC. Pharmacological antagonists of excitant amino acid action. Life Sciences. 28: 1303-8. PMID 6113524 DOI: 10.1016/0024-3205(81)90401-X  1
1981 Watkins JC, Evans RH. Excitatory amino acid transmitters. Annual Review of Pharmacology and Toxicology. 21: 165-204. PMID 6112965 DOI: 10.1146/annurev.pa.21.040181.001121  1
1981 Davies J, Francis AA, Jones AW, Watkins JC. 2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation. Neuroscience Letters. 21: 77-81. PMID 6111052 DOI: 10.1016/0304-3940(81)90061-6  1
1981 Watkins JC, Davies J, Evans RH, Francis AA, Jones AW. Pharmacology of receptors for excitatory amino acids. Advances in Biochemical Psychopharmacology. 27: 263-73. PMID 6108694  1
1981 Evans RH, Smith DAS, Watkins JC. Differential role of excitant amino acid receptors in spinal transmission Journal of Physiology. 55P.  1
1981 Evans RH, Smith DAS, Watkins JC. Amino acid antagonist property of urethane British Journal of Pharmacology. 74: 908P.  1
1981 Evans RH, Jones AW, Watkins JC. Depressant action of the L-glutamate analogue (+)2-amino-4-phosphonobutyrate British Journal of Pharmacology. 74: 907P.  1
1981 Hill RG, Salt TE, Watkins JC. The effects of cis-2,3-piperidine dicarboxylic acid (PDA) and γ-D-glutamylglycine (DGG) on amino acid and low-threshold sensory (LTS) responses of rat caudal trigeminal nucleus (NtV) neurones Journal of Physiology. 21P.  1
1980 Watkins J, Abbott EC, Hensby CN, Webster J, Dollery CT. Attenuation of hypotensive effect of propranolol and thiazide diuretics by indomethacin British Medical Journal. 281: 702-705. PMID 7427409  1
1980 Brown MJ, Dollery CT, Fitzgerald GA, Watkins J, Zamboulis C. No evidence for antagonism of clonidine by naloxone in man [proceedings]. British Journal of Clinical Pharmacology. 9: 302P. PMID 7362753  1
1980 Francis AA, Jones AW, Watkins JC. Dipeptide antagonists of amino acid-induced and synaptic excitation in the frog spinal cord. Journal of Neurochemistry. 35: 1458-60. PMID 6969293  1
1980 Ault B, Evans RH, Francis AA, Oakes DJ, Watkins JC. Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations. The Journal of Physiology. 307: 413-28. PMID 6259339  1
1980 Watkins J, FitzGerald G, Zamboulis C, Brown MJ, Dollery CT. Absence of opiate and histamine H2 receptor-mediated effects of clonidine. Clinical Pharmacology and Therapeutics. 28: 605-10. PMID 6254720  1
1980 Watkins JC. NMDA receptors. New light on amino acid-mediated synaptic excitation Trends in Neurosciences. 3: 61-64. DOI: 10.1016/S0166-2236(80)80153-6  1
1980 Evans RH, Jones AW, Watkins JC. Willardiine: A potent quisqualate-like excitant Journal of Physiology. 71P-72P.  1
1980 Davies J, Francis AA, Jones AW, Watkins JC. Dipeptide antagonists of amino acid-induced and synaptic excitation in the vertebrate central nervous system Journal of Physiology. 21p-22p.  1
1980 Davies J, Francis AA, Jones AW, Watkins JC. 2-Amino-5-phosphonovalerate (2APV), a highly potent and specific antagonist at spinal NMDA receptors British Journal of Pharmacology. 70: 52p-53p.  1
1979 Davies J, Watkins JC. Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord. The Journal of Physiology. 297: 621-35. PMID 536925  1
1979 Evans RH, Francis AA, Hunt K, Oakes DJ, Watkins JC. Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. British Journal of Pharmacology. 67: 591-603. PMID 316343  1
1979 Davies J, Evans RH, Francis AA, Watkins JC. Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system. Journal De Physiologie. 75: 641-54. PMID 232719  1
1978 Evans RH, Watkins JC. Do primary afferent terminals have acidic amino acid receptors? [proceedings]. British Journal of Pharmacology. 64: 385P-386P. PMID 719243  1
1978 Biscoe TJ, Davies J, Dray A, Evans RH, Martin MR, Watkins JC. D-alpha-aminoadipate, alpha, epsilon-diominopimelic acid and HA-966 as antagonists of amino acid-induced and synpatic excitation of mammalian spinal neurones in vivo. Brain Research. 148: 543-8. PMID 207393 DOI: 10.1016/0006-8993(78)90745-X  1
1978 Evans RH, Francis AA, Watkins JC. Mg2+-like selective antagonism of excitatory amino acid-induced responses by alpha, epsilon-diaminopimelic acid, D-alpha-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat. Brain Research. 148: 536-42. PMID 207392 DOI: 10.1016/0006-8993(78)90744-8  1
1978 Evans RH, Francis AA, Hunt K, Martin MR, Watkins JC. Quisqualamine, a novel gamma-aminobutyric acid (GABA) related depressant amino acid. The Journal of Pharmacy and Pharmacology. 30: 364-7. PMID 26767 DOI: 10.1111/j.2042-7158.1978.tb13257.x  1
1977 Biscoe TJ, Davies J, Dray A, Evans RH, Francis AA, Martin MR, Watkins JC. Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by D-alpha-aminoadipate, alpha,epsilon-diaminopimelic acid and HA-966. European Journal of Pharmacology. 45: 315-6. PMID 923641 DOI: 10.1016/0014-2999(77)90017-6  1
1977 Evans RH, Francis AA, Watkins JC. Selective antagonism by Mg2+ of amino acid-induced depolarization of frog and rat spinal neurones [proceedings]. The Journal of Physiology. 265: 42P-43P. PMID 850181  1
1977 Taberner PV, Pearce MJ, Watkins JC. The inhibition of mouse brain glutamate decarboxylase by some structural analogues of L-glutamic acid. Biochemical Pharmacology. 26: 345-9. PMID 849326 DOI: 10.1016/0006-2952(77)90188-5  1
1977 Evans RH, Francis AA, Watkins JC. Effects of monovalent cations on the responses of motoneurones to different groups to amino acid excitants in frog and rat spinal cord. Experientia. 33: 246-8. PMID 844576 DOI: 10.1007/BF02124092  1
1977 Evans RH, Francis AA, Watkins JC. Differential antagonism by chlorpromazine and diazepam of frog motoneurone depolarization induced by glutamate-related amino acids. European Journal of Pharmacology. 44: 325-30. PMID 302213 DOI: 10.1016/0014-2999(77)90306-5  1
1977 Evans RH, Francis AA, Watkins JC. Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones. Experientia. 33: 489-91. PMID 301099 DOI: 10.1007/BF01922227  1
1977 Biscoe TJ, Evans RH, Francis AA, Martin MR, Watkins JC, Davies J, Dray A. D-alpha-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones. Nature. 270: 743-5. PMID 22820 DOI: 10.1038/270743a0  1
1977 Watkins JC, Curtis DR, Brand SS. Phosphonic analogues as antagonists of amino acid excitants. The Journal of Pharmacy and Pharmacology. 29: 324. PMID 17707  1
1976 Evans RH, Francis AA, Watkins JC. Bimodal action of glycine on frog spinal motoneurones. Brain Research. 118: 395-401. PMID 1087578 DOI: 10.1016/0006-8993(76)90307-3  1
1976 Evans RH, Francis AA, Watkins JC. Ionic dependency of ventral root responses to excitatory amino acids in isolated spinal cord of frog and rat [proceedings]. The Journal of Physiology. 263: 122P-123P. PMID 1011094  1
1976 Biscoe TJ, Headley PM, Lodge D, Martin MR, Watkins JC. The sensitivity of rat spinal interneurones and renshaw cells to L-glutamate and L-aspartate. Experimental Brain Research. 26: 547-51. PMID 1010006 DOI: 10.1007/BF00238827  1
1976 Biscoe TJ, Evans RH, Headley PM, Martin MR, Watkins JC. Structure-activity relations of excitatory amino acids on frog and rat spinal neurones. British Journal of Pharmacology. 58: 373-82. PMID 990592 DOI: 10.1111/j.1476-5381.1976.tb07714.x  1
1972 Curtis DR, Duggan AW, Felix D, Johnston GA, Teb ecis AK, Watkins JC. Excitation of mammalian central neurones by acidic amino acids. Brain Research. 41: 283-301. PMID 4402606  1
1971 Watkins JC, Curtis DR, Felix D. Effect of intracellular injection of pyridine nucleotides on electrical responses of cat spinal motoneurones. Brain Research. 35: 570-2. PMID 4332606  1
1966 Watkins JC, Curtis DR, Biscoe TJ. Central effects of beta-N-oxalyl-alpha,beta-diaminopropionic acid and other lathyrus factors. Nature. 211: 637. PMID 5968735  1
1966 Curtis DR, Ryall RW, Watkins JC. The action of cholinomimetics on spinal interneurones. Experimental Brain Research. 2: 97-106. PMID 5921136  1
1965 Curtis DR, Watkins JC. The pharmacology of amino acids related to gamma-aminobutyric acid. Pharmacological Reviews. 17: 347-91. PMID 5321711  1
1964 RYALL RW, STONE NE, CURTIS DR, WATKINS JC. ACTION OF ACETYLCHOLINE EXTRACTED FROM BRAIN ON SPINAL RENSHAW CELLS. Nature. 201: 1034-5. PMID 14191577  1
1963 CURTIS DR, WATKINS JC. Acidic amino acids with strong excitatory actions on mammalian neurones. The Journal of Physiology. 166: 1-14. PMID 14024354  1
1961 CURTIS DR, PHILLIS JW, WATKINS JC. Cholinergic and non-cholinergic transmission in the mammalian spinal cord. The Journal of Physiology. 158: 296-323. PMID 13882769  1
1961 CURTIS DR, WATKINS JC. Analogues of glutamic and gamma-amino-n-butyric acids having potent actions on mammalian neurones. Nature. 191: 1010-1. PMID 13718947  1
1961 CURTIS DR, PHILLIS JW, WATKINS JC. Actions of aminoacids on the isolated hemisected spinal cord of the toad. British Journal of Pharmacology and Chemotherapy. 16: 262-83. PMID 13718946  1
1960 CURTIS DR, PHILLIS JW, WATKINS JC. The chemical excitation of spinal neurones by certain acidic amino acids. The Journal of Physiology. 150: 656-82. PMID 13813400  1
1960 CURTIS DR, WATKINS JC. The excitation and depression of spinal neurones by structurally related amino acids. Journal of Neurochemistry. 6: 117-41. PMID 13718948  1
1960 CURTIS DR, PERRIN DD, WATKINS JC. The excitation of spinal neurones by the ionophoretic application of agents which chelate calcium. Journal of Neurochemistry. 6: 1-20. PMID 13718945  1
1959 CURTIS DR, PHILLIS JW, WATKINS JC. The depression of spinal neurones by gamma-amino-n-butyric acid and beta-alanine. The Journal of Physiology. 146: 185-203. PMID 13655226  1
1959 CURTIS DR, PHILLIS JW, WATKINS JC. Chemical excitation of spinal neurones. Nature. 183: 611-2. PMID 13632811  1
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