Barry O'Keefe - Publications

Affiliations: 
1994-1996 Laboratory of Drug Discovery Research & Development National Cancer Institute, Rockville, MD, United States 

121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Alsaidi S, Cornejal N, Mahoney O, Melo C, Verma N, Bonnaire T, Chang T, O'Keefe BR, Sailer J, Zydowsky TM, Teleshova N, Romero JAF. Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model. Marine Drugs. 19. PMID 34436255 DOI: 10.3390/md19080418  1
2021 Kim CK, Krumpe LRH, Smith E, Henrich CJ, Brownell I, Wendt KL, Cichewicz RH, O'Keefe BR, Gustafson KR. Roseabol A, a New Peptaibol from the Fungus . Molecules (Basel, Switzerland). 26. PMID 34208349 DOI: 10.3390/molecules26123594  1
2021 Jiang W, Wang D, Wilson BAP, Kang U, Bokesch HR, Smith EA, Wamiru A, Goncharova EI, Voeller D, Lipkowitz S, O'Keefe BR, Gustafson KR. Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge . Marine Drugs. 19. PMID 34202500 DOI: 10.3390/md19070361  1
2021 Fermaintt CS, Peramuna T, Cai S, Takahashi-Ruiz L, Essif JN, Grant CV, O'Keefe BR, Mooberry SL, Cichewicz RH, Risinger AL. Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential. Cancers. 13. PMID 34200174 DOI: 10.3390/cancers13112834  1
2021 Jiang W, Wang D, Wilson BAP, Voeller D, Bokesch HR, Smith EA, Lipkowitz S, O'Keefe BR, Gustafson KR. Sinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a sp. Soft Coral. Journal of Natural Products. PMID 34038132 DOI: 10.1021/acs.jnatprod.1c00367  1
2021 Woldemichael GM, O'Keefe BR. Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs. Structure (London, England : 1993). 29: 401-403. PMID 33961789 DOI: 10.1016/j.str.2021.03.010  0.4
2021 Wilson BAP, Voeller D, Smith EA, Wamiru A, Goncharova EI, Liu G, Lipkowitz S, O'Keefe BR. In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors. Slas Discovery : Advancing Life Sciences R & D. 24725552211000675. PMID 33882749 DOI: 10.1177/24725552211000675  1
2021 Wang D, Jiang W, Kim CK, Bokesch HR, Woldemichael GM, Gryder BE, Shern JF, Khan J, O'Keefe BR, Beutler JA, Gustafson KR. Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge sp. Organic Letters. PMID 33848174 DOI: 10.1021/acs.orglett.1c00743  1
2020 Krumpe LRH, Wilson BAP, Marchand C, Sunassee SN, Bermingham A, Wang W, Price E, Guszczynski T, Kelley JA, Gustafson KR, Pommier Y, Rosengren KJ, Schroeder CI, O'Keefe BR. Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I. Journal of the American Chemical Society. PMID 33263997 DOI: 10.1021/jacs.0c10418  1
2020 Shrivastava-Ranjan P, Lo MK, Chatterjee P, Flint M, Nichol ST, Montgomery JM, O'Keefe BR, Spiropoulou CF. Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture. Frontiers in Cellular and Infection Microbiology. 10: 561502. PMID 33251157 DOI: 10.3389/fcimb.2020.561502  1
2020 Ma H, Liang H, Cai S, O'Keefe BR, Mooberry SL, Cichewicz RH. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Journal of Natural Products. PMID 33226219 DOI: 10.1021/acs.jnatprod.0c00946  1
2020 Krushkal J, Negi S, Yee LM, Evans JR, Grkovic T, Palmisano A, Fang J, Sankaran H, McShane LM, Zhao Y, O'Keefe BR. Molecular Genomic Features Associated with in Vitro Response of the NCI-60 Cancer Cell Line Panel to Natural Products. Molecular Oncology. PMID 33169510 DOI: 10.1002/1878-0261.12849  1
2020 Kim CK, Wang D, Wilson BAP, Saurí J, Voeller D, Lipkowitz S, O'Keefe BR, Gustafson KR. Suberitamides A-C, Aryl Alkaloids from a sp. Marine Sponge that Inhibit Cbl-b Ubiquitin Ligase Activity. Marine Drugs. 18. PMID 33126420 DOI: 10.3390/md18110536  1
2020 Grant CV, Cai S, Risinger AL, Liang H, O'Keefe BR, Doench JG, Cichewicz RH, Mooberry SL. CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells. Journal of Natural Products. PMID 33021790 DOI: 10.1021/acs.jnatprod.0c00642  1
2020 Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Evans JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR. NCI Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library. Acs Chemical Biology. PMID 32223208 DOI: 10.1021/Acschembio.0C00139  1
2020 Wilson BAP, Thornburg CC, Henrich CJ, Grkovic T, O'Keefe BR. Creating and screening natural product libraries. Natural Product Reports. PMID 32186299 DOI: 10.1039/C9Np00068B  1
2020 Kil YS, Risinger AL, Petersen CL, Liang H, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of . Journal of Natural Products. PMID 32105068 DOI: 10.1021/Acs.Jnatprod.9B00896  1
2020 Tran TD, Wilson BAP, Henrich CJ, Wendt KL, King J, Cichewicz RH, Stchigel AM, Miller AN, O'Keefe BR, Gustafson KR. Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods. Phytochemistry. 173: 112278. PMID 32078832 DOI: 10.1016/J.Phytochem.2020.112278  1
2020 Lo MK, Spengler JR, Krumpe LRH, Welch SR, Chattopadhyay A, Harmon JR, Coleman-McCray JD, Scholte FEM, Hotard AL, Fuqua JL, Rose JK, Nichol ST, Palmer KE, O'Keefe BR, Spiropoulou CF. Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge. The Journal of Infectious Diseases. PMID 32037447 DOI: 10.1093/Infdis/Jiz630  1
2020 Pederson PE, Cai S, Carver CM, Grkovic T, O'Keefe BR, Risinger AL, Cichewicz RH, Mooberry SL. Abstract 1786: High expression of NCX-1 in triple negative breast cancer cell lines identifies a potential biomarker for sensitivity to cardiac glycosides Cancer Research. 80: 1786-1786. DOI: 10.1158/1538-7445.Am2020-1786  1
2019 Chang LS, Oblinger JL, Burns SS, Huang J, Anderson LW, Hollingshead MG, Shen R, Pan L, Agarwal G, Ren Y, Roberts RD, O'Keefe BR, Kinghorn AD, Collins JM. Targeting protein translation by rocaglamide and didesmethylrocaglamide to treat MPNST and other sarcomas. Molecular Cancer Therapeutics. PMID 31848295 DOI: 10.1158/1535-7163.Mct-19-0809  0.04
2019 Aimaiti S, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of . Molecules (Basel, Switzerland). 24. PMID 31694283 DOI: 10.3390/molecules24214005  1
2019 Miyake K, Morita C, Suzuki A, Matsushita N, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Prenylated Acetophloroglucinol Dimers from : Structure Elucidation and Total Synthesis. Journal of Natural Products. PMID 31550158 DOI: 10.1021/Acs.Jnatprod.9B00596  1
2019 He M, Grkovic T, Evans JR, Thornburg CC, Akee RK, Thompson JR, Whitt JA, Harris MJ, Loyal JA, Britt JR, Jia L, White JD, Newman DJ, O'Keefe BR. The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species. Fitoterapia. 104285. PMID 31386897 DOI: 10.1016/J.Fitote.2019.104285  1
2019 Tran TD, Cartner LK, Bokesch HR, Henrich CJ, Wang XW, Mahidol C, Ruchirawat S, Kittakoop P, O'Keefe BR, Gustafson KR. NMR Characterization of Rearranged Staurosporine Aglycone Analogues from the Marine Sponge Damiria sp. Magnetic Resonance in Chemistry : Mrc. PMID 31379005 DOI: 10.1002/mrc.4932  1
2019 Matarlo JS, Krumpe LRH, Heinz WF, Oh D, Shenoy SR, Thomas CL, Goncharova EI, Lockett SJ, O'Keefe BR. The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation. Cell Chemical Biology. PMID 31155509 DOI: 10.1016/j.chembiol.2019.04.011  1
2019 Cai S, Risinger AL, Petersen CL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines. Journal of Natural Products. PMID 30830773 DOI: 10.1021/Acs.Jnatprod.8B01015  1
2019 Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR. Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities. Journal of Natural Products. PMID 30600998 DOI: 10.1021/Acs.Jnatprod.8B00871  1
2018 Habibi P, Soccol CR, O'Keefe BR, Krumpe LRH, Wilson J, de Macedo LLP, Faheem M, Dos Santos VO, Prado GS, Botelho MA, Lacombe S, Grossi-de-Sa MF. Gene-silencing suppressors for high-level production of the HIV-1 entry inhibitor griffithsin in . Process Biochemistry (Barking, London, England). 70: 45-54. PMID 32288594 DOI: 10.1016/j.procbio.2018.04.006  1
2018 Grkovic T, Evans JR, Akee RK, Guo L, Davis M, Jato J, Grothaus PG, Ahalt-Gottholm M, Hollingshead M, Collins JM, Newman DJ, O'Keefe BR. Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens. Bioorganic & Medicinal Chemistry Letters. PMID 30553734 DOI: 10.1016/J.Bmcl.2018.12.019  1
2018 Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ, Gustafson KR. Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta. Journal of Natural Products. PMID 30495954 DOI: 10.1021/Acs.Jnatprod.8B00761  1
2018 Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, Lai M, Wesenberg A, Ugaonkar S, Levendosky K, Mizenina O, Kleinbeck K, Lifson JD, Peet MM, Lloyd Z, et al. Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo. Nature Communications. 9: 3881. PMID 30250170 DOI: 10.1038/S41467-018-06349-0  1
2018 White JD, O'Keefe BR, Sharma J, Javed G, Nukala V, Ganguly A, Khan IA, Kumar NB, Mukhtar H, Pauli GF, Walker L, Sivaram S, Rajaraman P, Trimble EL. India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base. Journal of Global Oncology. 1-10. PMID 30241135 DOI: 10.1200/Jgo.17.00099  0.01
2018 Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species. Journal of Natural Products. PMID 30106296 DOI: 10.1021/Acs.Jnatprod.8B00411  1
2018 Vamvaka E, Farré G, Molinos-Albert LM, Evans A, Canela-Xandri A, Twyman RM, Carrillo J, Ordóñez RA, Shattock RJ, O'Keefe BR, Clotet B, Blanco J, Khush GS, Christou P, Capell T. Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm. Proceedings of the National Academy of Sciences of the United States of America. PMID 30061386 DOI: 10.1073/pnas.1806022115  1
2018 Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Grkovic T, O'Keefe BR. NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening. Acs Chemical Biology. PMID 29812901 DOI: 10.1021/Acschembio.8B00389  1
2018 Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata. Organic Letters. PMID 29624062 DOI: 10.1021/acs.orglett.8b00624  1
2017 Jia L, Lin H, Oppenheim J, Howard OMZ, Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young MR, Li W, Newman D, O'Keefe BR, Beutler J, et al. US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer. Journal of the National Cancer Institute. Monographs. 2017. PMID 29140488 DOI: 10.1093/Jncimonographs/Lgx007  1
2017 Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL, Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Keefe BR. Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1). Slas Discovery. 2472555217717200. PMID 28697309 DOI: 10.1177/2472555217717200  1
2017 Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS. Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina. Organic Letters. PMID 28345939 DOI: 10.1021/Acs.Orglett.7B00496  1
2017 Mitchell CA, Ramessar K, O'Keefe BR. Antiviral lectins: Selective inhibitors of viral entry. Antiviral Research. PMID 28322922 DOI: 10.1016/J.Antiviral.2017.03.007  1
2017 Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa. Journal of Natural Products. PMID 28290698 DOI: 10.1021/acs.jnatprod.6b01151  1
2017 Suzuki Y, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. (-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks. Journal of Natural Products. PMID 28099003 DOI: 10.1021/acs.jnatprod.6b01153  1
2016 Robles AJ, Cai S, Du L, Shaffer CV, Grkovic T, Risinger AL, O'Keefe BR, Cichewicz RH, Mooberry SL. Identifying specific inhibitors of triple-negative breast cancer subtypes. Planta Medica. 81: S1-S381. PMID 27975763 DOI: 10.1055/S-0036-1596562  1
2016 He M, Grkovic T, Thornburg CC, Whitt J, Akee R, Thompson J, Britt J, Jia L, White J, Newman D, O'Keefe B. A prototype traditional Chinese medicinal plant library at the National Cancer Institute. Planta Medica. 81: S1-S381. PMID 27975690 DOI: 10.1055/S-0036-1596489  1
2016 Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K. Acetophenone Monomers from Acronychia trifoliolata. Journal of Natural Products. PMID 27797192 DOI: 10.1021/acs.jnatprod.6b00645  1
2016 Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, Christou P, Capell T. Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro. Plant Cell Reports. 35: 1309-19. PMID 27007716 DOI: 10.1007/s00299-016-1963-5  1
2016 Chau CH, O'Keefe BR, Figg WD. The canSAR data hub for drug discovery. The Lancet. Oncology. 17: 286. PMID 26972856 DOI: 10.1016/S1470-2045(16)00095-4  0.01
2016 Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, Medina V, Stöger E, Christou P, Capell T. Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV. Plant Biotechnology Journal. PMID 26800650 DOI: 10.1111/Pbi.12507  1
2016 Shaffer C, Cai S, Perez A, Risinger A, Du L, O'Keefe B, Cichewicz R, Mooberry S. Abstract P5-04-18: Extracts derived from fungi and plants demonstrate specificity for subtyptes of triple negative breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P5-04-18  1
2015 Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR. Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor. Journal of Biomolecular Screening. PMID 26538432 DOI: 10.1177/1087057115615518  1
2015 Jakób M, Lubkowski J, O'Keefe BR, Wlodawer A. Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL). Acta Crystallographica. Section F, Structural Biology Communications. 71: 1429-36. PMID 26527272 DOI: 10.1107/S2053230X15019858  1
2015 Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rodriguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, Fernández-Romero JA. Griffithsin and carrageenan combination to target HSV-2 and HPV. Antimicrobial Agents and Chemotherapy. PMID 26369967 DOI: 10.1128/Aac.01816-15  1
2015 Chatterjee A, Ratner DM, Ryan CM, Johnson PJ, O'Keefe BR, Secor WE, Anderson DJ, Robbins PW, Samuelson J. Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model. Plos One. 10: e0135340. PMID 26252012 DOI: 10.1371/Journal.Pone.0135340  1
2015 Moulaei T, Alexandre KB, Shenoy SR, Meyerson JR, Krumpe LR, Constantine B, Wilson J, Buckheit RW, McMahon JB, Subramaniam S, Wlodawer A, O'Keefe BR. Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus. Retrovirology. 12: 6. PMID 25613831 DOI: 10.1186/S12977-014-0127-3  1
2015 O'Keefe BR, Murad AM, Vianna GR, Ramessar K, Saucedo CJ, Wilson J, Buckheit KW, da Cunha NB, Araújo AC, Lacorte CC, Madeira L, McMahon JB, Rech EL. Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV. Plant Biotechnology Journal. PMID 25572960 DOI: 10.1111/pbi.12309  1
2014 Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger GG, McMahon JB, Huggins J, O'Keefe BR. The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus. Antiviral Research. 112: 1-7. PMID 25265598 DOI: 10.1016/J.Antiviral.2014.09.012  1
2014 Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, et al. Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins. Journal of Biomolecular Screening. 19: 1201-1211. PMID 24870016 DOI: 10.1177/1087057114536227  1
2014 Sztuba-Solinska J, Shenoy SR, Gareiss P, Krumpe LR, Le Grice SF, O'Keefe BR, Schneekloth JS. Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays. Journal of the American Chemical Society. 136: 8402-10. PMID 24820959 DOI: 10.1021/Ja502754F  1
2014 Jensen SM, Ruscetti FW, Rein A, Bertolette DC, Saucedo CJ, O'Keefe BR, Jones KS. Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses. Journal of Virology. 88: 2327-32. PMID 24284326 DOI: 10.1128/JVI.02553-13  1
2014 Barton C, Kouokam JC, Lasnik AB, Foreman O, Cambon A, Brock G, Montefiori DC, Vojdani F, McCormick AA, O'Keefe BR, Palmer KE. Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models. Antimicrobial Agents and Chemotherapy. 58: 120-7. PMID 24145548 DOI: 10.1128/AAC.01407-13  1
2014 Bermingham A, Price E, Marchand C, Whitson E, Gustafson K, McMahon J, Pommier Y, O'Keefe B. A screen for the identification of inhibitors of tyrosyl-DNA phosphodiesterase 1 Planta Medica. 80. DOI: 10.1055/S-0034-1382735  1
2014 Chan S, Henrich C, O'Keefe B, McKee T, McMahon J, Gustafson K. Isolation and identification of biologically active natural products from marine ascidians Planta Medica. 80. DOI: 10.1055/S-0034-1382375  1
2013 Alexandre KB, Moore PL, Nonyane M, Gray ES, Ranchobe N, Chakauya E, McMahon JB, O'Keefe BR, Chikwamba R, Morris L. Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN. Virology. 446: 66-76. PMID 24074568 DOI: 10.1016/j.virol.2013.07.019  1
2013 Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, O'Keefe BR. Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus. Plos One. 8: e64449. PMID 23700478 DOI: 10.1055/S-0032-1320301  1
2013 Divlianska D, Wright A, Francis S, Walters M, Salomon C, Diaz P, Hassig C, O'Keefe B, Reed J, Roth G. In Search of Novel Cancer Therapeutics: Assessing the NCI Natural Product Library against Ten Anti-Apoptotic Protein Targets Planta Medica. 79. DOI: 10.1055/S-0033-1348587  0.01
2012 Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors. Journal of Medicinal Chemistry. 55: 7297. PMID 22891611 DOI: 10.1021/Jm301167V  1
2012 Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Bermingam A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. Journal of Medicinal Chemistry. 55: 4457-78. PMID 22536944 DOI: 10.1021/Jm300335N  1
2012 Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L. The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells. Virology. 423: 175-86. PMID 22209231 DOI: 10.1016/j.virol.2011.12.001  1
2011 Kouokam JC, Huskens D, Schols D, Johannemann A, Riedell SK, Walter W, Walker JM, Matoba N, O'Keefe BR, Palmer KE. Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate. Plos One. 6: e22635. PMID 21829638 DOI: 10.1371/journal.pone.0022635  1
2011 Alexandre KB, Gray ES, Pantophlet R, Moore PL, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L. Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site. Journal of Virology. 85: 9039-50. PMID 21697467 DOI: 10.1128/JVI.02675-10  1
2010 Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryotic Cell. 9: 1661-8. PMID 20852023 DOI: 10.1128/Ec.00166-10  1
2010 Moulaei T, Shenoy SR, Giomarelli B, Thomas C, McMahon JB, Dauter Z, O'Keefe BR, Wlodawer A. Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure (London, England : 1993). 18: 1104-15. PMID 20826337 DOI: 10.1016/j.str.2010.05.016  1
2010 Moulaei T, Stuchlik O, Reed M, Yuan W, Pohl J, Lu W, Haugh-Krumpe L, O'Keefe BR, Wlodawer A. Topology of the disulfide bonds in the antiviral lectin scytovirin. Protein Science : a Publication of the Protein Society. 19: 1649-61. PMID 20572021 DOI: 10.1002/pro.445  1
2010 Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF. Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrobial Agents and Chemotherapy. 54: 3913-21. PMID 20547794 DOI: 10.1128/Aac.00434-10  1
2010 Alexandre KB, Gray ES, Lambson BE, Moore PL, Choge IA, Mlisana K, Karim SS, McMahon J, O'Keefe B, Chikwamba R, Morris L. Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin. Virology. 402: 187-96. PMID 20392471 DOI: 10.1016/J.Virol.2010.03.021  1
2010 O'Keefe BR, Giomarelli B, Barnard DL, Shenoy SR, Chan PK, McMahon JB, Palmer KE, Barnett BW, Meyerholz DK, Wohlford-Lenane CL, McCray PB. Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. Journal of Virology. 84: 2511-21. PMID 20032190 DOI: 10.1128/Jvi.02322-09  1
2010 Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J. Suggestive evidence for Darwinian selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii Eukaryotic Cell. 9: 228-241. PMID 19783771 DOI: 10.1128/Ec.00197-09  1
2010 O'Keefe BR, Giomarelli B, Barnard DL, Shenoy SR, Chan PKS, McMahon JB, Palmer KE, Barnett BW, Meyerholz DK, Wohlford-Lenane CL, McCray PB. Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae (Journal of Virology (2010) 84, 5 (2511-2010)) Journal of Virology. 84: 5456. DOI: 10.1128/JVI.00537-10  1
2009 O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component Proceedings of the National Academy of Sciences of the United States of America. 106: 6099-6104. PMID 19332801 DOI: 10.1073/pnas.0901506106  1
2009 Bermingham A, Price E, Marchand C, Pommier Y, Goncharova K, Evans J, McMahon J, O'Keefe B. Abstract A174: High‐throughput screening for natural product inhibitors of human tyrosyl‐DNA‐phosphodiesterase (Tdp‐1) Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A174  1
2008 Weissman AM, Yang Y, Kitagaki J, Sasiela CA, Beutler JA, O'Keefe BR. Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer. Ernst Schering Foundation Symposium Proceedings. 171-90. PMID 19202599  1
2008 Clement JA, Kitagaki J, Yang Y, Saucedo CJ, O'Keefe BR, Weissman AM, McKee TC, McMahon JB. Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. Bioorganic & Medicinal Chemistry. 16: 10022-8. PMID 18977148 DOI: 10.1016/J.Bmc.2008.10.024  1
2008 Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, Götte M, Kvaratskhelia M, Le Grice S. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. Acs Chemical Biology. 3: 635-44. PMID 18831589 DOI: 10.1021/Cb8001039  1
2008 Smee DF, Bailey KW, Wong MH, O'Keefe BR, Gustafson KR, Mishin VP, Gubareva LV. Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N. Antiviral Research. 80: 266-71. PMID 18601954 DOI: 10.1016/j.antiviral.2008.06.003  1
2008 Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR. Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen. Journal of Biomolecular Screening. 13: 229-37. PMID 18270365 DOI: 10.1177/1087057108315038  1
2007 Smee DF, Wandersee MK, Checketts MB, O'Keefe BR, Saucedo C, Boyd MR, Mishin VP, Gubareva LV. Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor. Antiviral Chemistry & Chemotherapy. 18: 317-27. PMID 18320936  1
2007 Moulaei T, Botos I, Ziółkowska NE, Bokesch HR, Krumpe LR, McKee TC, O'Keefe BR, Dauter Z, Wlodawer A. Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Science : a Publication of the Protein Society. 16: 2756-60. PMID 17965185 DOI: 10.1110/ps.073157507  1
2007 Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB. An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis. Journal of Natural Products. 70: 1647-9. PMID 17935297 DOI: 10.1021/Np0702279  1
2007 Emau P, Tian B, O'Keefe BR, Mori T, McMahon JB, Palmer KE, Jiang Y, Bekele G, Tsai CC. Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide Journal of Medical Primatology. 36: 244-253. PMID 17669213 DOI: 10.1111/j.1600-0684.2007.00242.x  1
2007 Ziółkowska NE, Shenoy SR, O'Keefe BR, Wlodawer A. Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine. Protein Science : a Publication of the Protein Society. 16: 1485-9. PMID 17567736 DOI: 10.1110/ps.072889407  1
2007 McFeeters RL, Xiong C, O'Keefe BR, Bokesch HR, McMahon JB, Ratner DM, Castelli R, Seeberger PH, Byrd RA. The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors. Journal of Molecular Biology. 369: 451-61. PMID 17434526 DOI: 10.1016/J.Jmb.2007.03.030  1
2007 Zió?kowska NE, Shenoy SR, O'Keefe BR, McMahon JB, Palmer KE, Dwek RA, Wormald MR, Wlodawer A. Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins. 67: 661-70. PMID 17340634 DOI: 10.1002/Prot.21336  1
2006 Ziółkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A. Domain-Swapped Structure of the Potent Antiviral Protein Griffithsin and Its Mode of Carbohydrate Binding Structure. 14: 1127-1135. PMID 16843894 DOI: 10.1016/j.str.2006.05.017  1
2006 Xiong C, O'Keefe BR, Byrd RA, McMahon JB. Potent anti-HIV activity of scytovirin domain 1 peptide. Peptides. 27: 1668-75. PMID 16647158 DOI: 10.1016/J.Peptides.2006.03.018  1
2006 Xiong C, O'Keefe BR, Botos I, Wlodawer A, McMahon JB. Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Protein Expression and Purification. 46: 233-9. PMID 16289703 DOI: 10.1016/j.pep.2005.09.019  1
2005 Maderia M, Wu J, Bax A, Shenoy S, O'Keefe B, Marquez VE, Barchi JJ. Engineering DNA topology with locked nucleosides: a structural study. Nucleosides, Nucleotides & Nucleic Acids. 24: 687-90. PMID 16248015 DOI: 10.1081/Ncn-200060256  0.01
2005 Witvrouw M, Fikkert V, Hantson A, Pannecouque C, O'keefe BR, McMahon J, Stamatatos L, de Clercq E, Bolmstedt A. Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. Journal of Virology. 79: 7777-84. PMID 15919930 DOI: 10.1128/Jvi.79.12.7777-7784.2005  1
2005 Mori T, O'Keefe BR, Sowder RC, Bringans S, Gardella R, Berg S, Cochran P, Turpin JA, Buckheit RW, McMahon JB, Boyd MR. Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. The Journal of Biological Chemistry. 280: 9345-53. PMID 15613479 DOI: 10.1074/jbc.M411122200  1
2004 Bringans SD, O'Keefe BR, Bray M, Whitehouse CA, Boyd MR. Development of a fluorescent microplate assay for determining cyanovirin-N levels in plasma. Analytical and Bioanalytical Chemistry. 380: 269-74. PMID 15338095 DOI: 10.1007/s00216-004-2786-8  1
2004 Adams EW, Ratner DM, Bokesch HR, McMahon JB, O'Keefe BR, Seeberger PH. Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions. Chemistry & Biology. 11: 875-81. PMID 15217620 DOI: 10.1016/J.Chembiol.2004.04.010  1
2004 Bokesch HR, Charan RD, Meragelman KM, Beutler JA, Gardella R, O'Keefe BR, McKee TC, McMahon JB. Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea. Febs Letters. 567: 287-90. PMID 15178338 DOI: 10.1016/J.Febslet.2004.04.085  1
2004 Milanowski DJ, Rashid MA, Gustafson KR, O'Keefe BR, Nawrocki JP, Pannell LK, Boyd MR. Cyclonellin, a new cyclic octapeptide from the marine sponge Axinella carteri. Journal of Natural Products. 67: 441-4. PMID 15043426 DOI: 10.1021/np030336x  1
2004 Ratner DM, Adams EW, Su J, O'Keefe BR, Mrksich M, Seeberger PH. Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides Chembiochem. 5: 379-382. PMID 14997532 DOI: 10.1002/Cbic.200300804  1
2004 O'Keefe B. Protein Physics By Alexei V. Finkelstein and Oleg B. Ptitsyn (Russian Academy of Sciences). Academic Press, Amsterdam. 2002. xvi + 354 pp. 6 × 9 in. $80.00. ISBN 0-12-256781-1. Journal of Natural Products. 67: 523-524. DOI: 10.1021/Np030716I  0.01
2003 Adams EW, Ueberfeld J, Ratner DM, O'Keefe BR, Walt DR, Seeberger PH. Encoded fiber-optic microsphere arrays for probing protein-carbohydrate interactions. Angewandte Chemie (International Ed. in English). 42: 5317-20. PMID 14613164 DOI: 10.1002/Anie.200351286  1
2003 O'Keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Mori T, Blakeslee D, Buckheit R, Boyd MR. Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin. Antimicrobial Agents and Chemotherapy. 47: 2518-25. PMID 12878514  1
2003 Barrientos LG, O'Keefe BR, Bray M, Sanchez A, Gronenborn AM, Boyd MR. Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus Antiviral Research. 58: 47-56. PMID 12719006 DOI: 10.1016/S0166-3542(02)00183-3  1
2003 Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC, Turpin J, Watson K, Buckheit RW, Boyd MR. A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry. 42: 2578-84. PMID 12614152 DOI: 10.1021/bi0205698  1
2002 Shenoy SR, Barrientos LG, Ratner DM, O'Keefe BR, Seeberger PH, Gronenborn AM, Boyd MR. Multisite and multivalent binding between cyanovirin-N and branched oligomannosides: calorimetric and NMR characterization. Chemistry & Biology. 9: 1109-18. PMID 12401495 DOI: 10.1016/S1074-5521(02)00237-5  1
2002 Botos I, O'Keefe BR, Shenoy SR, Cartner LK, Ratner DM, Seeberger PH, Boyd MR, Wlodawer A. Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides. The Journal of Biological Chemistry. 277: 34336-42. PMID 12110688 DOI: 10.1074/Jbc.M205909200  1
2002 Barrientos LG, Louis JM, Botos I, Mori T, Han Z, O'Keefe BR, Boyd MR, Wlodawer A, Gronenborn AM. The domain-swapped dimer of cyanovirin-N is in a metastable folded state: Reconciliation of X-ray and NMR structures Structure. 10: 673-686. PMID 12015150 DOI: 10.1016/S0969-2126(02)00758-X  1
2002 Beutler JA, McMahon JB, Johnson TR, O'Keefe BR, Buzzell RA, Robbins D, Gardella R, Wilson J, Boyd MR. High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41. Journal of Biomolecular Screening. 7: 105-10. PMID 12006108 DOI: 10.1177/108705710200700202  1
2002 Barrientos LG, Louis JM, Hung J, Smith TH, O'Keefe BR, Gardella RS, Mori T, Boyd MR, Gronenborn AM. Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N Proteins: Structure, Function and Genetics. 46: 153-160. PMID 11807943 DOI: 10.1002/Prot.10024  1
2001 Bolmstedt AJ, O'Keefe BR, Shenoy SR, McMahon JB, Boyd MR. Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner. Molecular Pharmacology. 59: 949-54. PMID 11306674 DOI: 10.1124/MOL.59.5.949  1
2000 Charan RD, Munro MH, O'Keefe BR, Sowder RCII, McKee TC, Currens MJ, Pannell LK, Boyd MR. Isolation and characterization of Myrianthus holstii lectin, a potent HIV-1 inhibitory protein from the plant Myrianthus holstii(1). Journal of Natural Products. 63: 1170-4. PMID 10978222 DOI: 10.1021/Np000039H  1
2000 McMahon JB, Beutler JA, O'Keefe BR, Goodrum CB, Myers MA, Boyd MR. Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence. Journal of Biomolecular Screening. 5: 169-76. PMID 10894760 DOI: 10.1177/108705710000500309  1
1998 O'Keefe BR, Erim T, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Johnson DG, Buckheit RW, Halliday S, Boyd MR. Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp. Febs Letters. 431: 85-90. PMID 9684871 DOI: 10.1016/S0014-5793(98)00736-4  1
1997 O'Keefe BR, Beutler JA, Cardellina JH, Prather TR, Shoemaker RH, Sowder RC, Henderson LE, Pannell LK, Boyd MR. Isolation of a novel Kunitz family protease inhibitor in association with Tethya hemolysin from the sponge Tethya ingalli. Journal of Natural Products. 60: 1094-9. PMID 9392878 DOI: 10.1021/Np970242L  1
1997 O'Keefe BR, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Henderson LE, Pannell LK, Pomponi SA, Boyd MR. Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta. European Journal of Biochemistry / Febs. 245: 47-53. PMID 9128723 DOI: 10.1111/J.1432-1033.1997.T01-1-00047.X  1
1997 O'Keefe BR, Mahady GB, Gills JJ, Beecher CWW, Schilling AB. Stable vindoline production in transformed cell cultures of Catharanthus roseus Journal of Natural Products. 60: 261-264. DOI: 10.1021/Np960703N  1
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