Sarah Ellen O'Connor - Related publications

Affiliations: 
2003-2011 Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
 2011- Biological Chemistry John Innes Center 
Area:
Biosynthesis and engineering of plant and plant-pathogen natural products
Website:
https://www.jic.ac.uk/people/professor-sarah-e-oconnor/
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Li J, Xu F, Ji D, Tian C, Sun Y, Mutanda I, Ren Y, Wang Y. Diversion of metabolic flux towards 5-deoxy(iso)flavonoid production via enzyme self-assembly in . Metabolic Engineering Communications. 13: e00185. PMID 34631421 DOI: 10.1016/j.mec.2021.e00185   
2021 Vittorazzi PC, Marques JA, Takiya CS, Chesini RG, Bugoni M, da Silva GG, Nunes AT, Silva TBP, Dias MSS, Grigoletto NTS, Cortinhas CS, Acedo TS, Renno FP. Increasing doses of carbohydrases: Effects on rumen fermentation, nutrient digestibility, and performance of mid-lactation cows. Journal of Dairy Science. 104: 12508-12519. PMID 34600703 DOI: 10.3168/jds.2021-20514   
2021 Sharma V, Pugazhenthi G, Vasanth D. Production and characterization of a novel thermostable laccase from Bacillus licheniformis VNQ and its application in synthesis of bioactive 1,4-naphthoquinones. Journal of Bioscience and Bioengineering. PMID 34629297 DOI: 10.1016/j.jbiosc.2021.09.008   
2021 Li H, He YH, Hu YM, Chu QR, Chen YJ, Wu ZR, Zhang ZJ, Liu YQ, Yang CJ, Liang HJ, Yan YF. Design, Synthesis, and Structure-Activity Relationship Studies of Magnolol Derivatives as Antifungal Agents. Journal of Agricultural and Food Chemistry. PMID 34582205 DOI: 10.1021/acs.jafc.1c01838   
2021 Alafnan A, Sridharagatta S, Saleem H, Khurshid U, Alamri A, Ansari SY, Zainal Abidin SA, Ansari SA, Alamri AS, Ahemad N, Anwar S. Evaluation of the Phytochemical, Antioxidant, Enzyme Inhibition, and Wound Healing Potential of (L.) Dryand: A Source of a Bioactive Medicinal Product. Frontiers in Pharmacology. 12: 701369. PMID 34483902 DOI: 10.3389/fphar.2021.701369   
2021 Chen YJ, Ma KY, Du SS, Zhang ZJ, Wu TL, Sun Y, Liu YQ, Yin XD, Zhou R, Yan YF, Wang RX, He YH, Chu QR, Tang C. Antifungal Exploration of Quinoline Derivatives against Phytopathogenic Fungi Inspired by Quinine Alkaloids. Journal of Agricultural and Food Chemistry. PMID 34623798 DOI: 10.1021/acs.jafc.1c05677   
2021 Liu Q, Liu Y, Li G, Savolainen O, Chen Y, Nielsen J. De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories. Nature Communications. 12: 6085. PMID 34667183 DOI: 10.1038/s41467-021-26361-1   
2021 Wei X, Matsuyama T, Sato H, Yan D, Chan PM, Miyamoto K, Uchiyama M, Matsuda Y. Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis. Journal of the American Chemical Society. PMID 34644070 DOI: 10.1021/jacs.1c08336   
2021 Keziah SM, Devi CS. Fibrinolytic and ACE Inhibitory Activity of Nattokinase Extracted from Bacillus subtilis VITMS 2: A Strain Isolated from Fermented Milk of Vigna unguiculata. The Protein Journal. 40: 876-890. PMID 34611797 DOI: 10.1007/s10930-021-10023-8   
2021 Chen Y, Wu J, Yu D, Du X. Advances in steroidal saponins biosynthesis. Planta. 254: 91. PMID 34617240 DOI: 10.1007/s00425-021-03732-y   
2021 Wang S, Chen J, Shi J, Wang Z, Hu D, Song B. Novel Cinnamic Acid Derivatives Containing the 1,3,4-Oxadiazole Moiety: Design, Synthesis, Antibacterial Activities, and Mechanisms. Journal of Agricultural and Food Chemistry. PMID 34597041 DOI: 10.1021/acs.jafc.1c03087   
2021 Duhan M, Kumar P, Sindhu J, Singh R, Devi M, Kumar A, Kumar R, Lal S. Exploring biological efficacy of novel benzothiazole linked 2,5-disubstituted-1,3,4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization, inhibition, molecular docking, molecular dynamics and Monte Carlo based QSAR studies. Computers in Biology and Medicine. 138: 104876. PMID 34598068 DOI: 10.1016/j.compbiomed.2021.104876   
2021 Schultz F, Osuji OF, Wack B, Anywar G, Garbe LA. Antiinflammatory Medicinal Plants from the Ugandan Greater Mpigi Region Act as Potent Inhibitors in the COX-2/PGH Pathway. Plants (Basel, Switzerland). 10. PMID 33673238 DOI: 10.3390/plants10020351   
2021 Dey D, Dhar D, Fortunato H, Obata D, Tanaka A, Tanaka R, Basu S, Ito H. Insights into the structure and function of the rate-limiting enzyme of chlorophyll degradation through analysis of a bacterial Mg-dechelatase homolog. Computational and Structural Biotechnology Journal. 19: 5333-5347. PMID 34745453 DOI: 10.1016/j.csbj.2021.09.023   
2021 Marđetko N, Trontel A, Novak M, Pavlečić M, Ljubas BD, Grubišić M, Tominac VP, Ludwig R, Šantek B. Screening of Lignocellulolytic Enzyme Activities in Fungal Species and Sequential Solid-State and Submerged Cultivation for the Production of Enzyme Cocktails. Polymers. 13. PMID 34771293 DOI: 10.3390/polym13213736   
2021 Moore SJ, Tosi T, Bell D, Hleba YB, Polizzi KM, Freemont PS. High-yield 'one-pot' biosynthesis of raspberry ketone, a high-value fine chemical. Synthetic Biology (Oxford, England). 6: ysab021. PMID 34712844 DOI: 10.1093/synbio/ysab021   
2021 Zhang L, Feng XZ, Xiao ZQ, Fan GR, Chen SX, Liao SL, Luo H, Wang ZD. Design, Synthesis, Antibacterial, Antifungal and Anticancer Evaluations of Novel -Pinene Quaternary Ammonium Salts. International Journal of Molecular Sciences. 22. PMID 34681957 DOI: 10.3390/ijms222011299   
2021 Zhang JH, Xie HX, Li Y, Wang KM, Song Z, Zhu KK, Fang L, Zhang J, Jiang CS. Design, synthesis and biological evaluation of novel (E)-2-benzylidene-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)hydrazine-1-carboxamide derivatives as α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 128413. PMID 34634473 DOI: 10.1016/j.bmcl.2021.128413   
2021 Zhang TJ, Tu S, Zhang X, Wang QY, Hu SS, Zhang Y, Zhang ZH, Wang ZR, Meng FH. Amide-based xanthine oxidase inhibitors bearing an N-(1-alkyl-3-cyano-1H-indol-5-yl) moiety: Design, synthesis and structure-activity relationship investigation. Bioorganic Chemistry. 117: 105417. PMID 34673452 DOI: 10.1016/j.bioorg.2021.105417   
2021 Bi H, Qu G, Wang S, Zhuang Y, Sun Z, Liu T, Ma Y. Biosynthesis of a rosavin natural product in Escherichia coli by glycosyltransferase rational design and artificial pathway construction. Metabolic Engineering. PMID 34715353 DOI: 10.1016/j.ymben.2021.10.010   
2021 Bisht R, Bhattacharyya A, Shrivastava A, Saxena P. An Overview of the Medicinally Important Plant Type III PKS Derived Polyketides. Frontiers in Plant Science. 12: 746908. PMID 34721474 DOI: 10.3389/fpls.2021.746908   
2021 Li Q, Ge L, Zheng D, Zhang X, Zhao L. Screening and characterization of a GH78 α-l-rhamnosidase from Aspergillus terreus and its application in the bioconversion of icariin to icaritin with recombinant β-glucosidase. Enzyme and Microbial Technology. 153: 109940. PMID 34781207 DOI: 10.1016/j.enzmictec.2021.109940   
2021 Yamamoto K, Grzech D, Koudounas K, Stander EA, Caputi L, Mimura T, Courdavault V, O'Connor SE. Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus. Plant Physiology. 187: 846-857. PMID 34608956 DOI: 10.1093/plphys/kiab285   
2021 Dissanayake AA, Mills GL, Bonito G, Rennick B, Nair MG. Chemical Composition and Anti-Inflammatory and Antioxidant Activities of Extracts from Cultivated Morel Mushrooms, Species of Genus Morchella (Ascomycota). International Journal of Medicinal Mushrooms. 23: 73-83. PMID 34591400 DOI: 10.1615/IntJMedMushrooms.2021039297   
2021 Linz AM, Ma Y, Perez JM, Myers KS, Kontur WS, Noguera DR, Donohue TJ. Aromatic dimer dehydrogenases from reduce monoaromatic diketones. Applied and Environmental Microbiology. AEM0174221. PMID 34613756 DOI: 10.1128/AEM.01742-21   
2021 Duong TH, Nguyen HT, Nguyen CH, Tran NM, Danova A, Tran TM, Vu-Huynh KL, Musa V, Jutakanoke R, Nguyen NH, Sichaem J. Identification of Highly Potent α-Glucosidase Inhibitors from Artocarpus integer and Molecular Docking Studies. Chemistry & Biodiversity. e2100499. PMID 34761862 DOI: 10.1002/cbdv.202100499   
2021 Kurze E, Ruß V, Syam N, Effenberger I, Jonczyk R, Liao J, Song C, Hoffmann T, Schwab W. Glucosylation of (±)-Menthol by Uridine-Diphosphate-Sugar Dependent Glucosyltransferases from Plants. Molecules (Basel, Switzerland). 26. PMID 34576983 DOI: 10.3390/molecules26185511   
2021 , Lambré C, Barat Baviera JM, Bolognesi C, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lampi E, Mengelers M, Mortensen A, Rivière G, Steffensen IL, Tlustos C, Van Loveren H, et al. Safety evaluation of the food enzyme d-psicose 3-epimerase from the genetically modified strain FIS002. Efsa Journal. European Food Safety Authority. 19: e06870. PMID 34703502 DOI: 10.2903/j.efsa.2021.6870   
2021 Wang J, Anderson K, Yang E, He L, Lidstrom ME. Enzyme engineering and testing of a formate reduction pathway. Synthetic Biology (Oxford, England). 6: ysab020. PMID 34651085 DOI: 10.1093/synbio/ysab020   
2021 Wang Y, Shi Y, Li K, Yang D, Liu N, Zhang L, Zhao L, Zhang X, Liu Y, Gao L, Xia T, Wang P. Roles of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily in the Flavonoid Pathway: A Review of the Functional Diversity of F3H, FNS I, FLS, and LDOX/ANS. Molecules (Basel, Switzerland). 26. PMID 34771153 DOI: 10.3390/molecules26216745   
2021 Tran LT, Techato K, Nguyen VB, Wang SL, Nguyen AD, Phan TQ, Doan MD, Phoungthong K. Utilization of Cassava Wastewater for Low-Cost Production of Prodigiosin via TNU01 Fermentation and Its Novel Potent α-Glucosidase Inhibitory Effect. Molecules (Basel, Switzerland). 26. PMID 34684851 DOI: 10.3390/molecules26206270   
2021 Xu L, Chang KC, Payne EM, Modavi C, Liu L, Palmer CM, Tao N, Alper HS, Kennedy RT, Cornett DS, Abate AR. Mapping enzyme catalysis with metabolic biosensing. Nature Communications. 12: 6803. PMID 34815408 DOI: 10.1038/s41467-021-27185-9   
2021 Khobragade TP, Sarak S, Pagar AD, Jeon H, Giri P, Yun H. Synthesis of Sitagliptin Intermediate by a Multi-Enzymatic Cascade System Using Lipase and Transaminase With Benzylamine as an Amino Donor. Frontiers in Bioengineering and Biotechnology. 9: 757062. PMID 34692666 DOI: 10.3389/fbioe.2021.757062   
2021 Xu JJ, Chang YM, Lu M, Tie Y, Dong YL, Chen GY, Ma ZQ, Liu XL, Li YQ. Two single mutations in carboxylesterase 001C improve fenvalerate hydrolase activity in Helicoverpa armigera. Pesticide Biochemistry and Physiology. 179: 104969. PMID 34802519 DOI: 10.1016/j.pestbp.2021.104969   
2021 Pogorevc D, Müller R. Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class. Microbial Biotechnology. PMID 34724343 DOI: 10.1111/1751-7915.13959   
2021 Zhang R, Tan S, Zhang B, Hu P, Li L. Cerium-Promoted Ginsenosides Accumulation by Regulating Endogenous Methyl Jasmonate Biosynthesis in Hairy Roots of . Molecules (Basel, Switzerland). 26. PMID 34577094 DOI: 10.3390/molecules26185623   
2021 Wang J, Su P, Gao L, Zhang Y, Wang J, Tu L, Zhao Y, Lu Y, Yin Y, Huang L, Gao W. A cytochrome P450 CYP81AM1 from Tripterygium wilfordii catalyses the C-15 hydroxylation of dehydroabietic acid. Planta. 254: 95. PMID 34643823 DOI: 10.1007/s00425-021-03743-9   
2021 Wang ZQ, Song H, Koleski EJ, Hara N, Park DS, Kumar G, Min Y, Dauenhauer PJ, Chang MCY. A dual cellular-heterogeneous catalyst strategy for the production of olefins from glucose. Nature Chemistry. PMID 34811478 DOI: 10.1038/s41557-021-00820-0   
2021 Jin LQ, Jin YT, Zhang JW, Liu ZQ, Zheng YG. Enhanced catalytic efficiency and thermostability of glucose isomerase from Thermoanaerobacter ethanolicus via site-directed mutagenesis. Enzyme and Microbial Technology. 152: 109931. PMID 34688091 DOI: 10.1016/j.enzmictec.2021.109931   
2021 Choub V, Ajuna HB, Won SJ, Moon JH, Choi SI, Maung CEH, Kim CW, Ahn YS. Antifungal Activity of CE 100 against Anthracnose Disease () and Growth Promotion of Walnut ( L.) Trees. International Journal of Molecular Sciences. 22. PMID 34638782 DOI: 10.3390/ijms221910438   
2021 Servi H, Goren N, Sen A, Servi EY. A new eudesmanolide from L. and biological activities of extracts. Natural Product Research. 1-11. PMID 34791965 DOI: 10.1080/14786419.2021.2005594   
2021 Ma QG, Tang Y, Sang ZP, Dong JH, Wei RR. Structurally diverse biflavonoids from the fruits of Citrus medica L. var. sarcodactylis Swingle and their hypolipidemic and immunosuppressive activities. Bioorganic Chemistry. 117: 105450. PMID 34710667 DOI: 10.1016/j.bioorg.2021.105450   
2021 Kitainda V, Jez JM. Structural Studies of Aliphatic Glucosinolate Chain-Elongation Enzymes. Antioxidants (Basel, Switzerland). 10. PMID 34573132 DOI: 10.3390/antiox10091500   
2021 Low YS, Garcia MD, Lonhienne T, Fraser JA, Schenk G, Guddat LW. Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports. 11: 21055. PMID 34702838 DOI: 10.1038/s41598-021-00349-9   
2021 Liao X, Teng L, Li W. Isolation and production of organic solvent tolerant protease from bacterial burn infection, Staphylococcus aureus KP091274. Cellular and Molecular Biology (Noisy-Le-Grand, France). 67: 142-147. PMID 34817325 DOI: 10.14715/cmb/2021.67.2.22   
2021 Zhang Y, Yang X, Luo ZX, Lai JL, Li C, Luo XG. Effects of polystyrene nanoplastics (PSNPs) on the physiology and molecular metabolism of corn (Zea mays L.) seedlings. The Science of the Total Environment. 150895. PMID 34655622 DOI: 10.1016/j.scitotenv.2021.150895   
2021 Xiao Z, Hou X, Zhang T, Yuan Y, Xiao J, Song W, Yue T. Starch-digesting product analysis based on the hydrophilic interaction liquid chromatography coupled mass spectrometry method to evaluate the inhibition of flavonoids on pancreatic α-amylase. Food Chemistry. 372: 131175. PMID 34653779 DOI: 10.1016/j.foodchem.2021.131175   
2021 Yu L, Zhou W, She Y, Ma H, Cai YS, Jiang M, Deng Z, Price NPJ, Chen W. Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system. Nature Communications. 12: 6633. PMID 34789759 DOI: 10.1038/s41467-021-26928-y   
2021 Pan X, Yang J, Xie P, Zhang J, Ke F, Guo X, Liang M, Liu L, Wang Q, Gao X. Enhancement of Activity and Thermostability of Keratinase From CCTCC AB2013184 by Directed Evolution With Noncanonical Amino Acids. Frontiers in Bioengineering and Biotechnology. 9: 770907. PMID 34733836 DOI: 10.3389/fbioe.2021.770907   
2021 Mahour R, Lee JW, Grimpe P, Boecker S, Grote V, Klamt S, Seidel-Morgenstern A, Rexer TFT, Reichl U. Cell-free multi-enzyme synthesis and purification of uridine diphosphate galactose. Chembiochem : a European Journal of Chemical Biology. PMID 34637168 DOI: 10.1002/cbic.202100361