| Year |
Citation |
Score |
| 2023 |
Yang X, Ong HW, Dickmander RJ, Smith JL, Brown JW, Tao W, Chang E, Moorman NJ, Axtman AD, Willson TM. Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A. Biorxiv : the Preprint Server For Biology. PMID 37292607 DOI: 10.1101/2023.05.15.540828 |
0.505 |
|
| 2023 |
Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, ... Axtman AD, et al. Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. Acs Chemical Neuroscience. PMID 37084253 DOI: 10.1021/acschemneuro.3c00135 |
0.442 |
|
| 2023 |
Davis-Gilbert ZW, Krämer A, Dunford JE, Howell S, Senbabaoglu F, Wells CI, Bashore FM, Havener TM, Smith JL, Hossain MA, Oppermann U, Drewry DH, Axtman AD. Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2. Acs Medicinal Chemistry Letters. 14: 432-441. PMID 37077385 DOI: 10.1021/acsmedchemlett.2c00530 |
0.34 |
|
| 2023 |
Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, ... Axtman AD, et al. A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective. Biorxiv : the Preprint Server For Biology. PMID 36798313 DOI: 10.1101/2023.02.09.527935 |
0.436 |
|
| 2022 |
Drewry DH, Potjewyd FM, Bayati A, Smith JL, Dickmander RJ, Howell S, Taft-Benz S, Min SM, Hossain MA, Heise M, McPherson PS, Moorman NJ, Axtman AD. Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses. Journal of Medicinal Chemistry. PMID 36111834 DOI: 10.1021/acs.jmedchem.2c00697 |
0.444 |
|
| 2022 |
Mishra S, Kinoshita C, Axtman AD, Young JE. Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Mircroglial Model. Frontiers in Molecular Neuroscience. 15: 824956. PMID 35774866 DOI: 10.3389/fnmol.2022.824956 |
0.355 |
|
| 2022 |
Yang X, Dickmander RJ, Bayati A, Taft-Benz SA, Smith JL, Wells CI, Madden EA, Brown JW, Lenarcic EM, Yount BL, Chang E, Axtman AD, Baric RS, Heise MT, McPherson PS, et al. Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses. Acs Chemical Biology. PMID 35723434 DOI: 10.1021/acschembio.2c00378 |
0.603 |
|
| 2022 |
Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, Major MB. Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveal unique roles for CK1γ3 in WNT signaling. The Journal of Biological Chemistry. 101986. PMID 35487243 DOI: 10.1016/j.jbc.2022.101986 |
0.316 |
|
| 2022 |
Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ, Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT, Nwogbo F, Pearce KH, ... ... Axtman AD, et al. AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery. Alzheimer's & Dementia (New York, N. Y.). 8: e12246. PMID 35475262 DOI: 10.1002/trc2.12246 |
0.498 |
|
| 2022 |
Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ, Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT, Nwogbo F, Pearce KH, ... ... Axtman AD, et al. Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology. Alzheimer's & Dementia (New York, N. Y.). 8: e12253. PMID 35434254 DOI: 10.1002/trc2.12253 |
0.515 |
|
| 2022 |
Yang X, Dickmander RJ, Bayati A, Taft-Benz SA, Smith JL, Brown JW, Lenarcic EM, Yount BL, Chang E, Axtman AD, Baric RS, Heise MT, McPherson PS, Moorman NJ, Willson TM. Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 35018375 DOI: 10.1101/2022.01.03.474779 |
0.594 |
|
| 2021 |
Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chemical Biology. PMID 33484635 DOI: 10.1016/j.chembiol.2020.12.013 |
0.391 |
|
| 2021 |
Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, et al. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. International Journal of Molecular Sciences. 22. PMID 33429995 DOI: 10.3390/ijms22020566 |
0.585 |
|
| 2020 |
Krahn AI, Wells C, Drewry DH, Beitel LK, Durcan TM, Axtman AD. Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases. Acs Chemical Neuroscience. PMID 32464049 DOI: 10.1021/acschemneuro.0c00176 |
0.398 |
|
| 2020 |
Wells C, Couñago RM, Limas JC, Almeida TL, Cook JG, Drewry DH, Elkins JM, Gileadi O, Kapadia NR, Lorente-Macias A, Pickett JE, Riemen A, Ruela-de-Sousa RR, Willson TM, Zhang C, ... ... Axtman AD, et al. SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K. Acs Medicinal Chemistry Letters. 11: 340-345. PMID 32184967 DOI: 10.1021/Acsmedchemlett.9B00399 |
0.563 |
|
| 2019 |
Axtman A, Drewry D, Wells C. CDK16: the pick of the understudied PCTAIRE kinases. Nature Reviews. Drug Discovery. 18: 489. PMID 31267068 DOI: 10.1038/d41573-019-00076-x |
0.3 |
|
| 2019 |
Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Reports. 26: 79-93.e8. PMID 30605688 DOI: 10.1016/J.Celrep.2018.12.023 |
0.522 |
|
| 2017 |
Drewry DH, Wells CI, Andrews DM, Angell R, Al-Ali H, Axtman AD, Capuzzi SJ, Elkins JM, Ettmayer P, Frederiksen M, Gileadi O, Gray N, Hooper A, Knapp S, Laufer S, et al. Progress towards a public chemogenomic set for protein kinases and a call for contributions. Plos One. 12: e0181585. PMID 28767711 DOI: 10.1371/Journal.Pone.0181585 |
0.592 |
|
| 2014 |
Wender PA, Axtman AD, Golden JE, Kee JM, Sirois LE, Quiroz RV, Stevens MC. Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors†Dedicated to Max Malacria, a friend and scholar whose science and creative contributions to step-economical synthesis have inspired us all and moved the field closer to the ideal.‡Electronic supplementary information (ESI) available: Synthetic procedures and spectral data. See DOI: 10.1039/c4qo00228hClick here for additional data file. Organic Chemistry Frontiers : An International Journal of Organic Chemistry / Royal Society of Chemistry. 1: 1166-1171. PMID 25632347 DOI: 10.1039/C4Qo00228H |
0.319 |
|
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