Paul A. Wender - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Organic, Organometallic, Bioorganic, and Medicinal Chemistry
Website:
https://chemistry.stanford.edu/faculty/paul-wender

223 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Singh J, Ripp A, Haas TM, Qiu D, Keller M, Wender PA, Siegel JS, Baldridge KK, Jessen HJ. Correction to "Synthesis of Modified Nucleoside Oligophosphates Simplified: Fast, Pure, and Protecting Group Free". Journal of the American Chemical Society. PMID 31580654 DOI: 10.1021/jacs.9b10441  0.32
2019 Singh J, Ripp A, Haas TM, Qiu D, Keller M, Wender PA, Siegel JS, Baldridge KK, Jessen HJ. Synthesis of modified nucleoside oligophosphates simplified: Fast, pure, and protecting group free. Journal of the American Chemical Society. PMID 31512870 DOI: 10.1021/jacs.9b08273  0.32
2019 Antonoplis A, Zang X, Wegner T, Wender PA, Cegelski L. Vancomycin-Arginine Conjugate Inhibits Growth of Carbapenem-Resistant and Targets Cell-Wall Synthesis. Acs Chemical Biology. PMID 31479234 DOI: 10.1021/acschembio.9b00565  0.4
2019 Benner NL, McClellan RL, Turlington CR, Haabeth OAW, Waymouth RM, Wender PA. Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery. Journal of the American Chemical Society. PMID 31083999 DOI: 10.1021/jacs.9b03154  0.44
2019 Huiting ED, Gittens K, Justement JS, Shi V, Blazkova J, Benko E, Kovacs C, Wender PA, Moir S, Sneller MC, Fauci AS, Chun TW. Impact of treatment interruption on HIV reservoirs and lymphocyte subsets in individuals who had initiated antiretroviral therapy during the early phase of infection. The Journal of Infectious Diseases. PMID 30840763 DOI: 10.1093/infdis/jiz100  0.44
2019 Haabeth OAW, Blake TR, McKinlay CJ, Tveita AA, Sallets A, Waymouth RM, Wender PA, Levy R. Local delivery of OX40L, CD80, and CD86 mRNA kindles global anti-cancer immunity. Cancer Research. PMID 30692215 DOI: 10.1158/0008-5472.CAN-18-2867  0.44
2019 Singh J, Steck N, De D, Hofer A, Ripp A, Captain I, Keller M, Wender P, Bhandari R, Jessen HJ. The cyclic phosphoramidite reagent c-PyPA enables iterative polyphosphorylations. Angewandte Chemie (International Ed. in English). PMID 30681761 DOI: 10.1002/anie.201814366  0.32
2018 Fernandes-Cunha GM, McKinlay CJ, Vargas JR, Jessen HJ, Waymouth RM, Wender PA. Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters. Acs Central Science. 4: 1394-1402. PMID 30410977 DOI: 10.1021/acscentsci.8b00470  0.44
2018 Antonoplis A, Zang X, Huttner MA, Chong K, Lee YB, Co JY, Amieva M, Kline K, Wender PA, Cegelski L. A dual function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells. Journal of the American Chemical Society. PMID 30388366 DOI: 10.1021/jacs.8b08711  0.44
2018 Haabeth OAW, Blake TR, McKinlay CJ, Waymouth RM, Wender PA, Levy R. mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 30201728 DOI: 10.1073/pnas.1810002115  0.44
2018 McKinlay CJ, Benner NL, Haabeth OA, Waymouth RM, Wender PA. Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891683 DOI: 10.1073/pnas.1805358115  0.44
2018 Marsden MD, Wu X, Navab SM, Loy BA, Schrier AJ, DeChristopher BA, Shimizu AJ, Hardman CT, Ho S, Ramirez CM, Wender PA, Zack JA. Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. Virology. 520: 83-93. PMID 29800728 DOI: 10.1016/j.virol.2018.05.006  0.52
2018 Benner NL, Near KE, Bachmann MH, Contag CH, Waymouth RM, Wender PA. Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs). Biomacromolecules. PMID 29727572 DOI: 10.1021/acs.biomac.8b00401  0.64
2018 Yang H, Staveness D, Ryckbosch SM, Axtman AD, Loy BA, Barnes AB, Pande VS, Schaefer J, Wender PA, Cegelski L. REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment. Acs Central Science. 4: 89-96. PMID 29392180 DOI: 10.1021/acscentsci.7b00475  0.68
2017 Wender PA, Hardman CT, Ho S, Jeffreys MS, Maclaren JK, Quiroz RV, Ryckbosch SM, Shimizu AJ, Sloane JL, Stevens MC. Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV. Science (New York, N.Y.). 358: 218-223. PMID 29026042 DOI: 10.1126/science.aan7969  0.92
2017 Marsden MD, Loy BA, Wu X, Ramirez CM, Schrier AJ, Murray D, Shimizu A, Ryckbosch SM, Near KE, Chun TW, Wender PA, Zack JA. In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication. Plos Pathogens. 13: e1006575. PMID 28934369 DOI: 10.1371/journal.ppat.1006575  0.52
2017 Ryckbosch SM, Wender PA, Pande VS. Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes. Nature Communications. 8: 6. PMID 28232750 DOI: 10.1038/s41467-016-0015-8  0.52
2017 McKinlay CJ, Vargas JR, Blake TR, Hardy JW, Kanada M, Contag CH, Wender PA, Waymouth RM. Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals. Proceedings of the National Academy of Sciences of the United States of America. PMID 28069945 DOI: 10.1073/pnas.1614193114  0.64
2016 Abdelnabi R, Staveness D, Near KE, Wender PA, Delang L, Neyts J, Leyssen P. Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism. Biochemical Pharmacology. PMID 27664855 DOI: 10.1016/j.bcp.2016.09.020  0.44
2016 McKinlay CJ, Waymouth RM, Wender PA. Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery. Journal of the American Chemical Society. PMID 26900771 DOI: 10.1021/jacs.5b13452  0.44
2016 Staveness D, Abdelnabi R, Near KE, Nakagawa Y, Neyts J, Delang L, Leyssen P, Wender PA. Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway. Journal of Natural Products. PMID 26900711 DOI: 10.1021/acs.jnatprod.5b01017  0.44
2016 Staveness D, Abdelnabi R, Schrier AJ, Loy BA, Verma VA, DeChristopher BA, Near KE, Neyts J, Delang L, Leyssen P, Wender PA. Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death. Journal of Natural Products. PMID 26900625 DOI: 10.1021/acs.jnatprod.5b01016  1
2016 Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ. Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo. Nature Communications. 7: 10622. PMID 26842801 DOI: 10.1038/ncomms10622  1
2015 Hsu HT, Trantow BM, Waymouth RM, Wender PA. Bioorthogonal Catalysis: A General Method To Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System. Bioconjugate Chemistry. PMID 26367192 DOI: 10.1021/acs.bioconjchem.5b00469  1
2015 Mustard TJ, Wender PA, Cheong PH. Catalytic Efficiency Is a Function of How Rhodium(I) (5 + 2) Catalysts Accommodate a Conserved Substrate Transition State Geometry: Induced Fit Model for Explaining Transition Metal Catalysis. Acs Catalysis. 5: 1758-1763. PMID 26146588 DOI: 10.1021/cs501828e  1
2015 Boudreault PL, Mattler JK, Wender PA. Studies on the regio- and diastereo-selective epoxidation of daphnanes and tiglianes. Tetrahedron Letters. 56: 3423-3427. PMID 26034334 DOI: 10.1016/j.tetlet.2015.01.126  1
2015 Wender PA, Jeffreys MS, Raub AG. Tetramethyleneethane Equivalents: Recursive Reagents for Serialized Cycloadditions. Journal of the American Chemical Society. PMID 25961416 DOI: 10.1021/jacs.5b04091  1
2015 Wender PA, Quiroz RV, Stevens MC. Function through synthesis-informed design. Accounts of Chemical Research. 48: 752-60. PMID 25742599 DOI: 10.1021/acs.accounts.5b00004  1
2015 Loy BA, Lesser AB, Staveness D, Billingsley KL, Cegelski L, Wender PA. Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy. Journal of the American Chemical Society. 137: 3678-85. PMID 25710634 DOI: 10.1021/jacs.5b00886  1
2015 Wender PA, Huttner MA, Staveness D, Vargas JR, Xu AF. Guanidinium-rich, glycerol-derived oligocarbonates: a new class of cell-penetrating molecular transporters that complex, deliver, and release siRNA. Molecular Pharmaceutics. 12: 742-50. PMID 25588140 DOI: 10.1021/mp500581r  1
2014 Wender PA, Axtman AD, Golden JE, Kee JM, Sirois LE, Quiroz RV, Stevens MC. Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors†Dedicated to Max Malacria, a friend and scholar whose science and creative contributions to step-economical synthesis have inspired us all and moved the field closer to the ideal.‡Electronic supplementary information (ESI) available: Synthetic procedures and spectral data. See DOI: 10.1039/c4qo00228hClick here for additional data file. Organic Chemistry Frontiers : An International Journal of Organic Chemistry / Royal Society of Chemistry. 1: 1166-1171. PMID 25632347 DOI: 10.1039/c4qo00228h  1
2014 Hong X, Stevens MC, Liu P, Wender PA, Houk KN. Reactivity and chemoselectivity of allenes in Rh(I)-catalyzed intermolecular (5 + 2) cycloadditions with vinylcyclopropanes: allene-mediated rhodacycle formation can poison Rh(I)-catalyzed cycloadditions. Journal of the American Chemical Society. 136: 17273-83. PMID 25379606 DOI: 10.1021/ja5098308  1
2014 Wender PA, Staveness D. Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold. Organic Letters. 16: 5140-3. PMID 25238640 DOI: 10.1021/ol502492b  1
2014 Wender PA, Nakagawa Y, Near KE, Staveness D. Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs. Organic Letters. 16: 5136-9. PMID 25238583 DOI: 10.1021/ol502491f  1
2014 Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery. Acs Nano. 8: 7723-32. PMID 25061969 DOI: 10.1021/nn5002694  1
2014 Wender PA, Inagaki F, Pfaffenbach M, Stevens MC. Propargyltrimethylsilanes as allene equivalents in transition metal-catalyzed [5 + 2] cycloadditions. Organic Letters. 16: 2923-5. PMID 24819093 DOI: 10.1021/ol501114q  1
2014 Vargas JR, Stanzl EG, Teng NN, Wender PA. Cell-penetrating, guanidinium-rich molecular transporters for overcoming efflux-mediated multidrug resistance. Molecular Pharmaceutics. 11: 2553-65. PMID 24798708 DOI: 10.1021/mp500161z  1
2014 Wender PA, Fournogerakis DN, Jeffreys MS, Quiroz RV, Inagaki F, Pfaffenbach M. Structural complexity through multicomponent cycloaddition cascades enabled by dual-purpose, reactivity regenerating 1,2,3-triene equivalents. Nature Chemistry. 6: 448-52. PMID 24755598 DOI: 10.1038/nchem.1917  1
2014 Wender PA. Toward the ideal synthesis and molecular function through synthesis-informed design. Natural Product Reports. 31: 433-40. PMID 24589860 DOI: 10.1039/c4np00013g  1
2014 Wender PA, Donnelly AC, Loy BA, Near KE, Staveness D. Rethinking the Role of Natural Products: Function-Oriented Synthesis, Bryostatin, and Bryologs Natural Products in Medicinal Chemistry. 473-544. DOI: 10.1002/9783527676545.ch14  1
2013 Wender PA, Billingsley KL. Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues. Synthesis. 45: 1815-1824. PMID 24672140 DOI: 10.1055/s-0033-1338860  1
2013 Wender PA. Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis. Tetrahedron. 69: 7529-7550. PMID 23956471 DOI: 10.1016/j.tet.2013.06.004  1
2013 Beans EJ, Fournogerakis D, Gauntlett C, Heumann LV, Kramer R, Marsden MD, Murray D, Chun TW, Zack JA, Wender PA. Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: 11698-703. PMID 23812750 DOI: 10.1073/pnas.1302634110  1
2013 Stanzl EG, Trantow BM, Vargas JR, Wender PA. Fifteen years of cell-penetrating, guanidinium-rich molecular transporters: basic science, research tools, and clinical applications. Accounts of Chemical Research. 46: 2944-54. PMID 23697862 DOI: 10.1021/ar4000554  1
2013 Ogawa Y, Painter PP, Tantillo DJ, Wender PA. Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization. The Journal of Organic Chemistry. 78: 104-15. PMID 23121542 DOI: 10.1021/jo301953h  1
2012 DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA. Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nature Chemistry. 4: 705-10. PMID 22914190 DOI: 10.1038/nchem.1395  1
2012 Geihe EI, Cooley CB, Simon JR, Kiesewetter MK, Edward JA, Hickerson RP, Kaspar RL, Hedrick JL, Waymouth RM, Wender PA. Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 13171-6. PMID 22847412 DOI: 10.1073/pnas.1211361109  1
2012 Hyman JM, Geihe EI, Trantow BM, Parvin B, Wender PA. A molecular method for the delivery of small molecules and proteins across the cell wall of algae using molecular transporters. Proceedings of the National Academy of Sciences of the United States of America. 109: 13225-30. PMID 22847404 DOI: 10.1073/pnas.1202509109  1
2012 Blazkova J, Chun TW, Belay BW, Murray D, Justement JS, Funk EK, Nelson A, Hallahan CW, Moir S, Wender PA, Fauci AS. Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapy. The Journal of Infectious Diseases. 206: 765-9. PMID 22732922 DOI: 10.1093/infdis/jis412  1
2012 Wender PA, Cooley CB, Geihe EI. Beyond Cell Penetrating Peptides: Designed Molecular Transporters. Drug Discovery Today. Technologies. 9: e49-e55. PMID 22712022 DOI: 10.1016/j.ddtec.2011.07.004  1
2012 Xu X, Liu P, Lesser A, Sirois LE, Wender PA, Houk KN. Ligand effects on rates and regioselectivities of Rh(I)-catalyzed (5 + 2) cycloadditions: a computational study of cyclooctadiene and dinaphthocyclooctatetraene as ligands. Journal of the American Chemical Society. 134: 11012-25. PMID 22668243 DOI: 10.1021/ja3041724  1
2012 Wender PA, Galliher WC, Bhat NM, Pillow TH, Bieber MM, Teng NN. Taxol-oligoarginine conjugates overcome drug resistance in-vitro in human ovarian carcinoma. Gynecologic Oncology. 126: 118-23. PMID 22484398 DOI: 10.1016/j.ygyno.2012.03.049  1
2012 Lopez-Campistrous A, Song X, Schrier AJ, Wender PA, Dower NA, Stone JC. Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines. Experimental Hematology. 40: 646-56.e2. PMID 22465296 DOI: 10.1016/j.exphem.2012.03.002  1
2012 DeChristopher BA, Fan AC, Felsher DW, Wender PA. "Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo. Oncotarget. 3: 58-66. PMID 22308267  1
2012 Wender PA, Lesser AB, Sirois LE. Rhodium dinaphthocyclooctatetraene complexes: synthesis, characterization and catalytic activity in [5+2] cycloadditions. Angewandte Chemie (International Ed. in English). 51: 2736-40. PMID 22298411 DOI: 10.1002/anie.201108270  1
2012 Wender PA, Lesser AB, Sirois LE. The preparation of cyclohept-4-enones by rhodium-catalyzed intermolecular [5+2] cycloaddition Organic Syntheses. 88: 109-120. DOI: 10.15227/orgsyn.088.0109  1
2011 Wender PA, Loy BA, Schrier AJ. Translating Nature's Library: The Bryostatins and Function-Oriented Synthesis. Israel Journal of Chemistry. 51: 453-472. PMID 22661768 DOI: 10.1002/ijch.201100020  1
2011 Wender PA, Reuber J. Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs. Tetrahedron. 67: 9998-10005. PMID 22247574 DOI: 10.1016/j.tet.2011.09.058  1
2011 Wender PA, Buschmann N, Cardin NB, Jones LR, Kan C, Kee JM, Kowalski JA, Longcore KE. Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities. Nature Chemistry. 3: 615-9. PMID 21778981 DOI: 10.1038/nchem.1074  1
2011 Wender PA, Schrier AJ. Total synthesis of bryostatin 9. Journal of the American Chemical Society. 133: 9228-31. PMID 21618969 DOI: 10.1021/ja203034k  1
2011 Wender PA, Baryza JL, Brenner SE, DeChristopher BA, Loy BA, Schrier AJ, Verma VA. Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity. Proceedings of the National Academy of Sciences of the United States of America. 108: 6721-6. PMID 21415363 DOI: 10.1073/pnas.1015270108  1
2011 Kiessling L. Mimic how nature makes polymers Nature. 469: 24. DOI: 10.1038/469023a  1
2010 Liu P, Sirois LE, Cheong PH, Yu ZX, Hartung IV, Rieck H, Wender PA, Houk KN. Electronic and steric control of regioselectivities in Rh(I)-catalyzed (5 + 2) cycloadditions: experiment and theory. Journal of the American Chemical Society. 132: 10127-35. PMID 20586494 DOI: 10.1021/ja103253d  1
2010 Wender PA, Sirois LE, Stemmler RT, Williams TJ. Highly efficient, facile, room temperature intermolecular [5 + 2] cycloadditions catalyzed by cationic rhodium(I): one step to cycloheptenes and their libraries. Organic Letters. 12: 1604-7. PMID 20196579 DOI: 10.1021/ol100337m  1
2010 Wender PA, Stemmler RT, Sirois LE. A metal-catalyzed intermolecular [5+2] cycloaddition/Nazarov cyclization sequence and cascade. Journal of the American Chemical Society. 132: 2532-3. PMID 20141136 DOI: 10.1021/ja910696x  1
2010 Bruckner R, Harmata M, Wender PA. Organic mechanisms: Reactions, stereochemistry and synthesis Organic Mechanisms: Reactions, Stereochemistry and Synthesis. 1-855. DOI: 10.1007/978-3-642-03651-4  1
2010 Croatt MP, Wender PA. The diene effect: The design, development, and Mechanistic investigation of metal-catalyzed diene-yne, diene-ene, and diene-allene [2+2+1] cycloaddition reactions European Journal of Organic Chemistry. 19-32. DOI: 10.1002/ejoc.200900929  1
2009 Wender PA, Longcore KE. Apoptolidins E and F, new glycosylated macrolactones isolated from Nocardiopsis sp. Organic Letters. 11: 5474-7. PMID 19943700 DOI: 10.1021/ol902308v  1
2009 Cooley CB, Trantow BM, Nederberg F, Kiesewetter MK, Hedrick JL, Waymouth RM, Wender PA. Oligocarbonate molecular transporters: oligomerization-based syntheses and cell-penetrating studies. Journal of the American Chemical Society. 131: 16401-3. PMID 19860416 DOI: 10.1021/ja907363k  1
2009 Lewis CA, Longcore KE, Miller SJ, Wender PA. An approach to the site-selective diversification of apoptolidin A with peptide-based catalysts. Journal of Natural Products. 72: 1864-9. PMID 19769383 DOI: 10.1021/np9004932  1
2009 Wender PA, Christy JP, Lesser AB, Gieseler MT. The synthesis of highly substituted cyclooctatetraene scaffolds by metal-catalyzed [2+2+2+2] cycloadditions: studies on regioselectivity, dynamic properties, and metal chelation. Angewandte Chemie (International Ed. in English). 48: 7687-90. PMID 19739178 DOI: 10.1002/anie.200903859  1
2009 Shaha SP, Tomic J, Shi Y, Pham T, Mero P, White D, He L, Baryza JL, Wender PA, Booth JW, Spaner DE. Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells. Clinical and Experimental Immunology. 158: 186-98. PMID 19737143 DOI: 10.1111/j.1365-2249.2009.04003.x  1
2009 Wender PA, Miller BL. Synthesis at the molecular frontier. Nature. 460: 197-201. PMID 19587760 DOI: 10.1038/460197a  1
2009 Wender PA, Strand D. Cyclocarboamination of alkynes with aziridines: synthesis of 2,3-dihydropyrroles by a catalyzed formal [3 + 2] cycloaddition. Journal of the American Chemical Society. 131: 7528-9. PMID 19489638 DOI: 10.1021/ja901799s  1
2009 Khan TK, Nelson TJ, Verma VA, Wender PA, Alkon DL. A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts. Neurobiology of Disease. 34: 332-9. PMID 19233276 DOI: 10.1016/j.nbd.2009.02.003  1
2009 Stang SL, Lopez-Campistrous A, Song X, Dower NA, Blumberg PM, Wender PA, Stone JC. A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells. Experimental Hematology. 37: 122-134. PMID 19100522 DOI: 10.1016/j.exphem.2008.09.008  1
2009 Wender PA, Croatt MP, Kühn B. Rhodium(I)-catalyzed [2+2], [2+2+2], and [2+2+2+2] cycloadditions of dienes or alkynes with a bis-ene Organometallics. 28: 5841-5844. DOI: 10.1021/om9007373  1
2008 Dubikovskaya EA, Thorne SH, Pillow TH, Contag CH, Wender PA. Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters. Proceedings of the National Academy of Sciences of the United States of America. 105: 12128-33. PMID 18713866 DOI: 10.1073/pnas.0805374105  1
2008 Mooberry SL, Hilinski MK, Clark EA, Wender PA. Function-oriented synthesis: biological evaluation of laulimalide analogues derived from a last step cross metathesis diversification strategy. Molecular Pharmaceutics. 5: 829-38. PMID 18662015 DOI: 10.1021/mp800043n  1
2008 Wender PA, Verma VA. The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity. Organic Letters. 10: 3331-4. PMID 18588309 DOI: 10.1021/ol801235h  1
2008 Lee HL, Dubikovskaya EA, Hwang H, Semyonov AN, Wang H, Jones LR, Twieg RJ, Moerner WE, Wender PA. Single-molecule motions of oligoarginine transporter conjugates on the plasma membrane of Chinese hamster ovary cells. Journal of the American Chemical Society. 130: 9364-70. PMID 18578528 DOI: 10.1021/ja710798b  1
2008 Wender PA, Dechristopher BA, Schrier AJ. Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy. Journal of the American Chemical Society. 130: 6658-9. PMID 18452292 DOI: 10.1021/ja8015632  1
2008 Wender PA, Kee JM, Warrington JM. Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science (New York, N.Y.). 320: 649-52. PMID 18451298 DOI: 10.1126/science.1154690  1
2008 Liu P, Cheong PH, Yu ZX, Wender PA, Houk KN. Substituent effects, reactant preorganization, and ligand exchange control the reactivity in Rh(I)-catalyzed (5+2) cycloadditions between vinylcyclopropanes and alkynes. Angewandte Chemie (International Ed. in English). 47: 3939-41. PMID 18412215 DOI: 10.1002/anie.200800420  1
2008 Yu ZX, Cheong PH, Liu P, Legault CY, Wender PA, Houk KN. Origins of differences in reactivities of alkenes, alkynes, and allenes in [Rh(CO)2Cl]2-catalyzed (5 + 2) cycloaddition reactions with vinylcyclopropanes. Journal of the American Chemical Society. 130: 2378-9. PMID 18251468 DOI: 10.1021/ja076444d  1
2008 Wender PA, Galliher WC, Goun EA, Jones LR, Pillow TH. The design of guanidinium-rich transporters and their internalization mechanisms. Advanced Drug Delivery Reviews. 60: 452-72. PMID 18164781 DOI: 10.1016/j.addr.2007.10.016  1
2008 Wender PA, Verma VA, Paxton TJ, Pillow TH. Function-oriented synthesis, step economy, and drug design. Accounts of Chemical Research. 41: 40-9. PMID 18159936 DOI: 10.1021/ar700155p  1
2007 Wender PA, Christy JP. Nickel(0)-catalyzed [2 + 2 + 2 + 2] cycloadditions of terminal diynes for the synthesis of substituted cyclooctatetraenes. Journal of the American Chemical Society. 129: 13402-3. PMID 17929819 DOI: 10.1021/ja0763044  1
2007 Wang Y, Wang J, Su J, Huang F, Jiao L, Liang Y, Yang D, Zhang S, Wender PA, Yu ZX. A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones. Journal of the American Chemical Society. 129: 10060-1. PMID 17655302 DOI: 10.1021/ja072505w  1
2007 Wender PA, Goun EA, Jones LR, Pillow TH, Rothbard JB, Shinde R, Contag CH. Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 10340-5. PMID 17563383 DOI: 10.1073/pnas.0703919104  1
2007 Wender PA, D'Angelo N, Elitzin VI, Ernst M, Jackson-Ugueto EE, Kowalski JA, McKendry S, Rehfeuter M, Sun R, Voigtlaender D. Function-oriented synthesis: studies aimed at the synthesis and mode of action of 1alpha-alkyldaphnane analogues. Organic Letters. 9: 1829-32. PMID 17408281 DOI: 10.1021/ol0705649  1
2007 Wender PA, Longcore KE. Isolation, structure determination, and anti-cancer activity of apoptolidin D. Organic Letters. 9: 691-4. PMID 17286376 DOI: 10.1021/ol0630245  1
2007 Gómez FJ, Kamber NE, Deschamps NM, Cole AP, Wender PA, Waymouth RM. N-alkoxyimidazolylidene transition-metal complexes: Application to [5+2] and [4+2] cycloaddition reactions Organometallics. 26: 4541-4545. DOI: 10.1021/om700493y  1
2007 Wender PA, Croatt MP, Deschamps NM. C-C bond formation (part 1) by addition reactions: Higher-order cycloadditions Comprehensive Organometallic Chemistry Iii. 10: 603-647.  1
2006 Wender PA, Paxton TJ, Williams TJ. Cyclopentadienone synthesis by rhodium(I)-catalyzed [3 + 2] cycloaddition reactions of cyclopropenones and alkynes. Journal of the American Chemical Society. 128: 14814-5. PMID 17105285 DOI: 10.1021/ja065868p  1
2006 Wender PA, Bi FC, Buschmann N, Gosselin F, Kan C, Kee JM, Ohmura H. Studies on oxidopyrylium [5+2] cycloadditions: toward a general synthetic route to the C12-hydroxydaphnetoxins. Organic Letters. 8: 5373-6. PMID 17078721 DOI: 10.1021/ol062234e  1
2006 Wender PA, Horan JC, Verma VA. Total synthesis and initial biological evaluation of new B-ring-modified bryostatin analogs. Organic Letters. 8: 5299-302. PMID 17078702 DOI: 10.1021/ol0620904  1
2006 Wender PA, Horan JC. Synthesis and PKC binding of a new class of a-ring diversifiable bryostatin analogues utilizing a double asymmetric hydrogenation and cross-coupling strategy. Organic Letters. 8: 4581-4. PMID 16986955 DOI: 10.1021/ol0618149  1
2006 Goun EA, Pillow TH, Jones LR, Rothbard JB, Wender PA. Molecular transporters: synthesis of oligoguanidinium transporters and their application to drug delivery and real-time imaging. Chembiochem : a European Journal of Chemical Biology. 7: 1497-515. PMID 16972294 DOI: 10.1002/cbic.200600171  1
2006 Wender PA, Hilinski MK, Skaanderup PR, Soldermann NG, Mooberry SL. Pharmacophore mapping in the laulimalide series: total synthesis of a vinylogue for a late-stage metathesis diversification strategy. Organic Letters. 8: 4105-8. PMID 16928085 DOI: 10.1021/ol061619u  1
2006 Clark EA, Hills PM, Davidson BS, Wender PA, Mooberry SL. Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol. Molecular Pharmaceutics. 3: 457-67. PMID 16889440 DOI: 10.1021/mp060016h  1
2006 Jones LR, Goun EA, Shinde R, Rothbard JB, Contag CH, Wender PA. Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release. Journal of the American Chemical Society. 128: 6526-7. PMID 16704230 DOI: 10.1021/ja0586283  1
2006 Goun EA, Shinde R, Dehnert KW, Adams-Bond A, Wender PA, Contag CH, Franc BL. Intracellular cargo delivery by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation. Bioconjugate Chemistry. 17: 787-96. PMID 16704219 DOI: 10.1021/bc0503216  1
2006 Wender PA, Haustedt LO, Lim J, Love JA, Williams TJ, Yoon JY. Asymmetric catalysis of the [5 + 2] cycloaddition reaction of vinylcyclopropanes and pi-systems. Journal of the American Chemical Society. 128: 6302-3. PMID 16683779 DOI: 10.1021/ja058590u  1
2006 Wender PA, Deschamps NM, Sun R. RhI-catalyzed C-C bond activation: seven-membered ring synthesis by a [6+1] carbonylative ring-expansion reaction of allenylcyclobutanes. Angewandte Chemie (International Ed. in English). 45: 3957-60. PMID 16683295 DOI: 10.1002/anie.200600806  1
2006 Wender PA, Verma VA. Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin. Organic Letters. 8: 1893-6. PMID 16623578 DOI: 10.1021/ol060457z  1
2006 Wender PA, Christy JP. Rhodium(I)-catalyzed [4+2+2] cycloadditions of 1,3-dienes, alkenes, and alkynes for the synthesis of cyclooctadienes. Journal of the American Chemical Society. 128: 5354-5. PMID 16620102 DOI: 10.1021/ja060878b  1
2006 Wender PA, Hilinski MK, Soldermann N, Mooberry SL. Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue. Organic Letters. 8: 1507-10. PMID 16562928 DOI: 10.1021/ol060233g  1
2006 Wender PA, Croatt MP, Deschamps NM. Metal-catalyzed [2+2+1] cycloadditions of 1,3-dienes, allenes, and CO. Angewandte Chemie (International Ed. in English). 45: 2459-62. PMID 16526073 DOI: 10.1002/anie.200600300  1
2006 Wender PA, Jankowski OD, Longcore K, Tabet EA, Seto H, Tomikawa T. Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Organic Letters. 8: 589-92. PMID 16468718 DOI: 10.1021/ol052800q  1
2006 Wender PA, Croatt MP, Witulski B. New reactions and step economy: the total synthesis of (±)-salsolene oxide based on the type II transition metal-catalyzed intramolecular [4+4] cycloaddition Tetrahedron. 62: 7505-7511. DOI: 10.1016/j.tet.2006.02.085  1
2006 Wender PA, Baryza JL, Hilinski MK, Horan JC, Kan C, Verma VA. Beyond Natural Products: Synthetic Analogues of Bryostatin 1 Drug Discovery Research: New Frontiers in the Post-Genomic Era. 125-162. DOI: 10.1002/9780470131862.ch6  1
2006 Rothbard JB, Jessop TC, Wender PA. Molecular understanding of cellular uptake by arginine-rich cell penetrating peptides Acs Symposium Series. 923: 166-181.  1
2005 Statsuk AV, Bai R, Baryza JL, Verma VA, Hamel E, Wender PA, Kozmin SA. Actin is the primary cellular receptor of bistramide A. Nature Chemical Biology. 1: 383-8. PMID 16372404  1
2005 Wender PA, Kreider E, Pelkey ET, Rothbard J, Vandeusen CL. Dendrimeric molecular transporters: synthesis and evaluation of tunable polyguanidino dendrimers that facilitate cellular uptake. Organic Letters. 7: 4815-8. PMID 16235896 DOI: 10.1021/ol051496y  1
2005 Wender PA, Sukopp M, Longcore K. Apoptolidins B and C: isolation, structure determination, and biological activity. Organic Letters. 7: 3025-8. PMID 15987196 DOI: 10.1021/ol051074o  1
2005 Wender PA, Clarke MO, Horan JC. Role of the A-ring of bryostatin analogues in PKC binding: synthesis and initial biological evaluation of new A-ring-modified bryologs. Organic Letters. 7: 1995-8. PMID 15876038 DOI: 10.1021/ol0504650  1
2005 Wegner HA, de Meijere A, Wender PA. Transition metal-catalyzed intermolecular [5+2] and [5+2+1] cycloadditions of allenes and vinylcyclopropanes. Journal of the American Chemical Society. 127: 6530-1. PMID 15869263 DOI: 10.1021/ja043671w  1
2005 Wender PA, Baryza JL. Identification of a tunable site in bryostatin analogs: C20 Bryologs through late stage diversification. Organic Letters. 7: 1177-80. PMID 15760168 DOI: 10.1021/ol0501931  1
2005 Wender PA, Gamber GG, Hubbard RD, Pham SM, Zhang L. Multicomponent cycloadditions: the four-component [5+1+2+1] cycloaddition of vinylcyclopropanes, alkynes, and CO. Journal of the American Chemical Society. 127: 2836-7. PMID 15740103 DOI: 10.1021/ja042728b  1
2005 Rothbard JB, Jessop TC, Wender PA. Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells. Advanced Drug Delivery Reviews. 57: 495-504. PMID 15722160 DOI: 10.1016/j.addr.2004.10.003  1
2005 Wender PA, Hilinski MK, Mayweg AV. Late-stage intermolecular CH activation for lead diversification: a highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues. Organic Letters. 7: 79-82. PMID 15624982 DOI: 10.1021/ol047859w  1
2005 Hammond C, Shi Y, Mena J, Tomic J, Cervi D, He L, Millar AE, Debenedette M, Schuh AC, Baryza JL, Wender PA, Radvanyi L, Spaner DE. Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 28: 28-39. PMID 15614042  1
2005 Wender PA, Deschamps NM, Sun R. Rh(I)-catalyzed cleavage of unactivated C-O bonds - Carbonylative rearrangement reactions of allenyl ethers to 2-carboalkoxy-1,3-dienes Canadian Journal of Chemistry. 83: 838-842. DOI: 10.1139/v05-085  1
2005 Wender PA, Gamber GG, Williams TJ. Rhodium(I)-Catalyzed [5+2], [6+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis Modern Rhodium-Catalyzed Organic Reactions. 263-299. DOI: 10.1002/3527604693.ch13  1
2004 Wender PA, Baryza JL, Brenner SE, Clarke MO, Craske ML, Horan JC, Meyer T. Function oriented synthesis: the design, synthesis, PKC binding and translocation activity of a new bryostatin analog. Current Drug Discovery Technologies. 1: 1-11. PMID 16472215  1
2004 Stone JC, Stang SL, Zheng Y, Dower NA, Brenner SE, Baryza JL, Wender PA. Synthetic bryostatin analogues activate the RasGRP1 signaling pathway. Journal of Medicinal Chemistry. 47: 6638-44. PMID 15588099 DOI: 10.1021/jm0495069  1
2004 Baryza JL, Brenner SE, Craske ML, Meyer T, Wender PA. Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP. Chemistry & Biology. 11: 1261-7. PMID 15380186 DOI: 10.1016/j.chembiol.2004.06.014  1
2004 Rothbard JB, Jessop TC, Lewis RS, Murray BA, Wender PA. Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells. Journal of the American Chemical Society. 126: 9506-7. PMID 15291531 DOI: 10.1021/ja0482536  1
2004 Yu ZX, Wender PA, Houk KN. On the mechanism of [Rh(CO)2Cl]2-catalyzed intermolecular (5 + 2) reactions between vinylcyclopropanes and alkynes. Journal of the American Chemical Society. 126: 9154-5. PMID 15281784 DOI: 10.1021/ja048739m  1
2004 Wender PA, Deschamps NM, Williams TJ. Intermolecular dienyl Pauson-Khand reaction. Angewandte Chemie (International Ed. in English). 43: 3076-9. PMID 15188486 DOI: 10.1002/anie.200454117  1
2004 Shi Kam NW, Jessop TC, Wender PA, Dai H. Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. Journal of the American Chemical Society. 126: 6850-1. PMID 15174838 DOI: 10.1021/ja0486059  1
2004 Mooberry SL, Randall-Hlubek DA, Leal RM, Hegde SG, Hubbard RD, Zhang L, Wender PA. Microtubule-stabilizing agents based on designed laulimalide analogues. Proceedings of the National Academy of Sciences of the United States of America. 101: 8803-8. PMID 15161976 DOI: 10.1073/pnas.0402759101  1
2004 Wender PA, Croatt MP, Deschamps NM. Rhodium(I)-catalyzed [2+2+1] cycloadditions of 1,3-dienes, alkenes, and CO. Journal of the American Chemical Society. 126: 5948-9. PMID 15137743 DOI: 10.1021/ja0489487  1
2003 Wender PA, Koehler MF, Sendzik M. A new synthetic approach to the C ring of known as well as novel bryostatin analogues. Organic Letters. 5: 4549-52. PMID 14627380 DOI: 10.1021/ol0355332  1
2003 Wender PA, Hegde SG, Hubbard RD, Zhang L, Mooberry SL. Synthesis and biological evaluation of (-)-laulimalide analogues. Organic Letters. 5: 3507-9. PMID 12967311 DOI: 10.1021/ol035339f  1
2003 Kirschberg TA, VanDeusen CL, Rothbard JB, Yang M, Wender PA. Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates. Organic Letters. 5: 3459-62. PMID 12967299 DOI: 10.1021/ol035234c  1
2003 Siprashvili Z, Scholl FA, Oliver SF, Adams A, Contag CH, Wender PA, Khavari PA. Gene transfer via reversible plasmid condensation with cysteine-flanked, internally spaced arginine-rich peptides. Human Gene Therapy. 14: 1225-33. PMID 12952594 DOI: 10.1089/104303403767740768  1
2003 Wender PA, Jankowski OD, Tabet EA, Seto H. Facile synthetic access to and biological evaluation of the macrocyclic core of apoptolidin. Organic Letters. 5: 2299-302. PMID 12816433 DOI: 10.1021/ol0346335  1
2003 Wender PA, Jeon R. Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates. Bioorganic & Medicinal Chemistry Letters. 13: 1763-6. PMID 12729660 DOI: 10.1016/S0960-894X(03)00212-9  1
2003 Wender PA, Deschamps NM, Gamber GG. The dienyl Pauson-Khand reaction. Angewandte Chemie (International Ed. in English). 42: 1853-7. PMID 12722081 DOI: 10.1002/anie.200350949  1
2003 Wright LR, Rothbard JB, Wender PA. Guanidinium rich peptide transporters and drug delivery. Current Protein & Peptide Science. 4: 105-24. PMID 12678850 DOI: 10.2174/1389203033487252  1
2003 Wender PA, Jankowski OD, Tabet EA, Seto H. Toward a structure-activity relationship for apoptolidin: selective functionalization of the hydroxyl group array. Organic Letters. 5: 487-90. PMID 12583750 DOI: 10.1021/ol027366w  1
2003 Wender PA, Mayweg AV, VanDeusen CL. A concise, selective synthesis of the polyketide spacer domain of a potent bryostatin analogue. Organic Letters. 5: 277-9. PMID 12556171 DOI: 10.1021/ol0272390  1
2003 Wender PA, Love JA, Williams TJ. Rhodium-catalyzed [5+2] cycloaddition reactions in water Synlett. 1295-1298.  1
2003 Wender PA. Actualite chimique: Foreword Actualite Chimique. 7-8.  1
2003 Wender PA, Baryza JL, Brenner SE, Clarke MO, Gamber GG, Horan JC, Jessop TC, Kan C, Pattabiraman K, Williams TJ. Inspirations from nature. New reactions, therapeutic leads, and drug delivery systems Pure and Applied Chemistry. 75: 143-155.  1
2002 Wender PA, Gulledge AV, Jankowski OD, Seto H. Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin. Organic Letters. 4: 3819-22. PMID 12599467 DOI: 10.1021/ol0266222  1
2002 Wender PA, Pedersen TM, Scanio MJ. Transition metal-catalyzed hetero-[5 + 2] cycloadditions of cyclopropyl imines and alkynes: dihydroazepines from simple, readily available starting materials. Journal of the American Chemical Society. 124: 15154-5. PMID 12487573 DOI: 10.1021/ja0285013  1
2002 Wender PA, Williams TJ. [(arene)Rh(cod)]+ Complexes as catalysts for [5+2] cycloaddition reactions. Angewandte Chemie (International Ed. in English). 41: 4550-3. PMID 12458535 DOI: 10.1002/1521-3773(20021202)41:23<4550::AID-ANIE4550>3.0.CO;2-D  1
2002 Wender PA, Baryza JL, Bennett CE, Bi FC, Brenner SE, Clarke MO, Horan JC, Kan C, Lacôte E, Lippa B, Nell PG, Turner TM. The practical synthesis of a novel and highly potent analogue of bryostatin. Journal of the American Chemical Society. 124: 13648-9. PMID 12431074 DOI: 10.1021/ja027509+  1
2002 Wender PA, Rothbard JB, Jessop TC, Kreider EL, Wylie BL. Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery. Journal of the American Chemical Society. 124: 13382-3. PMID 12418880 DOI: 10.1021/ja0275109  1
2002 Rothbard JB, Kreider E, VanDeusen CL, Wright L, Wylie BL, Wender PA. Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake. Journal of Medicinal Chemistry. 45: 3612-8. PMID 12166934 DOI: 10.1021/jm0105676  1
2002 Wender PA, Hegde SG, Hubbard RD, Zhang L. Total synthesis of (-)-laulimalide. Journal of the American Chemical Society. 124: 4956-7. PMID 11982349 DOI: 10.1021/ja0258428  1
2002 Wender PA, Gamber GG, Hubbard RD, Zhang L. Three-component cycloadditions: the first transition metal-catalyzed [5+2+1] cycloaddition reactions. Journal of the American Chemical Society. 124: 2876-7. PMID 11902870 DOI: 10.1021/ja0176301  1
2002 Wender PA, Bi FC, Gamber GG, Gosselin F, Hubbard RD, Scanio MJC, Sun R, Williams TJ, Zhang L. Toward the ideal synthesis. New transition metal-catalyzed reactions inspired by novel medicinal leads Pure and Applied Chemistry. 74: 25-31.  1
2002 Lakshmipathi P, Grée D, Grée R, Wender PA, D'Angelo N. A facile C-C bond cleavage in epoxides and its use for the synthesis of oxygenated heterocycles by a ring expansion strategy Chemtracts. 15: 183-188.  1
2001 Wender PA, Gamber GG, Scanio MJC. Serial [5+2]/[4+2] Cycloadditions: Facile, Preparative, Multi-Component Syntheses of Polycyclic Compounds from Simple, Readily Available Starting Materials. Angewandte Chemie (International Ed. in English). 40: 3895-3897. PMID 29712128 DOI: 10.1002/1521-3773(20011015)40:20<3895::AID-ANIE3895>3.0.CO;2-#  0.96
2001 Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D. Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chemistry & Biology. 8: 1123-9. PMID 11755391 DOI: 10.1016/S1074-5521(01)00076-X  1
2001 Wender PA, Gamber GG, Scanio MJ. Serial [5+2]/[4+2] Cycloadditions: Facile, Preparative, Multi-Component Syntheses of Polycyclic Compounds from Simple, Readily Available Starting Materials This research was supported by grant CHE-9800445 from the National Science Foundation. The Stanford Graduate Fellowship (M.J.C.S. and G.G.G.) is gratefully acknowledged. Angewandte Chemie (International Ed. in English). 40: 3895-3897. PMID 11668567 DOI: 10.1002/1521-3773(20011015)40:20<3895::AID-ANIE3895>3.0.CO;2-#  1
2001 Wender PA, Jessop TC, Pattabiraman K, Pelkey ET, VanDeusen CL. An efficient, scalable synthesis of the molecular transporter octaarginine via a segment doubling strategy. Organic Letters. 3: 3229-32. PMID 11594801 DOI: 10.1021/ol0161108  1
2001 Shindo M, Irie K, Nakahara A, Ohigashi H, Konishi H, Kikkawa U, Fukuda H, Wender PA. Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding. Bioorganic & Medicinal Chemistry. 9: 2073-81. PMID 11504643 DOI: 10.1016/S0968-0896(01)00100-6  1
2001 Wender PA, Bi FC, Brodney MA, Gosselin F. Asymmetric synthesis of the tricyclic core of NGF-inducing cyathane diterpenes via a transition-metal-catalyzed [5 + 2] cycloaddition. Organic Letters. 3: 2105-8. PMID 11418060 DOI: 10.1021/ol0160699  1
2001 Wender PA, Barzilay CM, Dyckman AJ. The first intermolecular transition metal-catalyzed [5+2] cycloadditions with simple, unactivated, vinylcyclopropanes. Journal of the American Chemical Society. 123: 179-80. PMID 11273617 DOI: 10.1021/ja0021159  1
2001 Tanaka M, Irie K, Nakagawa Y, Nakamura Y, Ohigashi H, Wender PA. The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding. Bioorganic & Medicinal Chemistry Letters. 11: 719-22. PMID 11266177 DOI: 10.1016/S0960-894X(01)00045-2  1
2001 Jeon R, Wender PA. Photocleavage of DNA by 4'-bromoacetophenone analogs. Archives of Pharmacal Research. 24: 39-43. PMID 11235810  1
2001 Glass T, Wender PA, Pattabiraman K, VanDeusen CL. Cooperative chemical sensing with bis-tritylacetylenes: Pinwheel receptors with metal ion recognition properties Chemtracts. 14: 186-189.  1
2000 Irie K, Nakahara A, Ikawa Y, Tanaka M, Nakagawa Y, Nakamura Y, Ohigashi H, Wender PA. Synthesis and tumor-promoting activities of 12-Epi-phorbol-12,13-dibutyrate. Bioscience, Biotechnology, and Biochemistry. 64: 2429-36. PMID 11193412  1
2000 Jeon R, Wender PA. Design and synthesis of new DNA photocleavers, 4'-bromoace-tophenone-pyrrolecarboxamide hybrid compounds. Archives of Pharmacal Research. 23: 585-8. PMID 11156179  1
2000 Wender PA, Mitchell DJ, Pattabiraman K, Pelkey ET, Steinman L, Rothbard JB. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proceedings of the National Academy of Sciences of the United States of America. 97: 13003-8. PMID 11087855 DOI: 10.1073/pnas.97.24.13003  1
2000 Rothbard JB, Garlington S, Lin Q, Kirschberg T, Kreider E, McGrane PL, Wender PA, Khavari PA. Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation. Nature Medicine. 6: 1253-7. PMID 11062537 DOI: 10.1038/81359  1
2000 Nakagawa Y, Irie K, Ohigashi H, Hayashi H, Wender PA. Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V. Bioorganic & Medicinal Chemistry Letters. 10: 2087-90. PMID 10999477 DOI: 10.1016/S0960-894X(00)00411-X  1
2000 Wender PA, Zhang L. Asymmetric total synthesis of (+)-aphanamol I based on the transition metal catalyzed [5 + 2] cycloaddition of allenes and vinylcyclopropanes. Organic Letters. 2: 2323-6. PMID 10930274  1
2000 Wender PA, Dyckman AJ, Husfeld CO, Scanio MJ. A new and practical five-carbon component for metal-catalyzed Organic Letters. 2: 1609-11. PMID 10841491  0.92
2000 Wender PA, Correa AG, Sato Y, Sun R. Transition metal-catalyzed [6+2] cycloadditions of 2-vinylcyclobutanones and alkenes: A new reaction for the synthesis of eight-membered rings [3] Journal of the American Chemical Society. 122: 7815-7816. DOI: 10.1021/ja001483+  1
2000 Wender PA, Lippa B. Synthesis and biological evaluation of bryostatin analogues: The role of the A-ring Tetrahedron Letters. 41: 1007-1011. DOI: 10.1016/S0040-4039(99)02195-4  1
2000 Wender PA, Hinkle KW. Synthesis and biological evaluation of a new class of bryostatin analogues: The role of the C20 substituent in protein kinase C binding Tetrahedron Letters. 41: 6725-6729.  1
2000 Wender PA, Dyckman AJ, Husfeld CO, Scanio MJC. A New and Practical Five-Carbon Component for Metal-Catalyzed [5 + 2] Cycloadditions: Preparative Scale Syntheses of Substituted Cycloheptenones Organic Letters. 2: 1609-1611.  1
1999 Wender PA, Jeon R. Bromoacetophenone-based photonucleases: photoinduced cleavage of DNA by 4'-bromoacetophenone-pyrrolecarboxamide conjugates. Organic Letters. 1: 2117-20. PMID 10836065  1
1999 Wender PA, Kirschberg TA, Williams PD, Bastiaans HM, Irie K. A new class of simplified phorbol ester analogues: synthesis and binding to PKC and eta PKC-C1B (eta PKC-CRD2). Organic Letters. 1: 1009-12. PMID 10825954  1
1999 Wender PA, Hinkle KW, Koehler MF, Lippa B. The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues. Medicinal Research Reviews. 19: 388-407. PMID 10502742 DOI: 10.1002/(SICI)1098-1128(199909)19:5<388::AID-MED6>3.0.CO;2-H  1
1999 Irie K, Nakahara A, Ohigashi H, Fukuda H, Wender PA, Konishi H, Kikkawa U. Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D. Bioorganic & Medicinal Chemistry Letters. 9: 2487-90. PMID 10498194 DOI: 10.1016/S0960-894X(99)00413-8  1
1999 Fukuda H, Irie K, Nakahara A, Ohigashi H, Wender PA. Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma. Bioorganic & Medicinal Chemistry. 7: 1213-21. PMID 10428394 DOI: 10.1016/S0968-0896(99)00037-1  1
1999 Wender PA, Lippa B, Park CM, Irie K, Nakahara A, Ohigashi H. Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes. Bioorganic & Medicinal Chemistry Letters. 9: 1687-90. PMID 10397502 DOI: 10.1016/S0960-894X(99)00263-2  1
1999 Wender PA, Dyckman AJ, Husfeld CO, Kadereit D, Love JA, Rieck H. Transition metal-catalyzed [5+2] cycloadditions with substituted cyclopropanes: First studies of regio- and stereoselectivity [14] Journal of the American Chemical Society. 121: 10442-10443. DOI: 10.1021/ja992580+  1
1999 Wender PA, Glorius F, Husfeld CO, Langkopf E, Love JA. Transition metal-catalyzed [5 + 2] cycloadditions of allenes and vinylcyclopropanes: First studies of endo-exo selectivity, chemoselectivity, relative stereochemistry, and chirality transfer Journal of the American Chemical Society. 121: 5348-5349. DOI: 10.1021/ja9903072  1
1999 Wender PA, Dyckman AJ. Transition metal-catalyzed [5 + 2] cycloadditions of 2-substituted-1-vinylcyclopropanes: Catalyst control and reversal of regioselectivity Organic Letters. 1: 2089-2092.  1
1999 Wender PA, Fuji M, Husfeld CO, Love JA. Rhodium-catalyzed [5 + 2] cycloadditions of allenes and vinylcyclopropanes: Asymmetric total synthesis of (+)-dictamnol Organic Letters. 1: 137-139.  1
1999 Wender PA, Koehler MFT, Wright DL, Irie K. Mapping phorbol ester binding domains of protein kinase C (PKC): The design, synthesis and biological activity of novel phorbol ester dimers Synthesis. 1401-1406.  1
1999 Corey EJ, Roberts BE, Boukouvalas J, Cheng YX, Robichaud J, Magnuson SR, Sepp-Lorenzino L, Rosen N, Danishefsky SJ, Wender PA, Love JA. Organic synthesis delivers on another medicinal lead: Total syntheses of dysidiolide Chemtracts. 12: 512-521.  1
1998 Wender PA, DeBrabander J, Harran PG, Jimenez JM, Koehler MF, Lippa B, Park CM, Siedenbiedel C, Pettit GR. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proceedings of the National Academy of Sciences of the United States of America. 95: 6624-9. PMID 9618462 DOI: 10.1073/pnas.95.12.6624  1
1998 Wender PA, Rieck H, Fuji M. The transition metal-catalyzed intermolecular [5+2] cycloaddition: The homologous Diels-Alder reaction [1] Journal of the American Chemical Society. 120: 10976-10977. DOI: 10.1021/ja982196x  1
1998 Irie K, Oie K, Nakahara A, Yanai Y, Ohigashi H, Wender PA, Fukuda H, Konishi H, Kikkawa U. Molecular basis for protein kinase C isozyme-selective binding: The synthesis, folding, and phorbol ester binding of the cysteine-rich domains of all protein kinase C isozymes Journal of the American Chemical Society. 120: 9159-9167. DOI: 10.1021/ja981087f  1
1998 Wender PA, Husfeld CO, Langkopf E, Love JA. First studies of the transition of metal-catalyzed [5+2] cycloadditions of alkenes and vinylcyclopropanes: Scope and stereochemistry Journal of the American Chemical Society. 120: 1940-1941. DOI: 10.1021/ja973650k  1
1998 Wender PA, De Brabander J, Harran PG, Limenez JM, Koehler MFT, Lippa B, Park CM, Shiozaki M. Synthesis of the first members of a new class of biologically active bryostatin analogues [2] Journal of the American Chemical Society. 120: 4534-4535. DOI: 10.1021/ja9727631  1
1998 Wender PA, Dore TM. A formal synthesis of crinipellin B based on the arene-alkene meta- photocycloaddition reaction Tetrahedron Letters. 39: 8589-8592. DOI: 10.1016/S0040-4039(98)01965-0  1
1998 Wender PA, De Brabander J, Harran PG, Hinkle KW, Lippa B, Pettit GR. Synthesis and biological evaluation of fully synthetic bryostatin analogues Tetrahedron Letters. 39: 8625-8628. DOI: 10.1016/S0040-4039(98)01955-8  1
1998 Fukuda H, Irie K, Nakahara A, Oie K, Ohigashi H, Wender PA. Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma Tetrahedron Letters. 39: 7943-7946. DOI: 10.1016/S0040-4039(98)01768-7  1
1998 Wender PA, Husfeld CO, Langkopf E, Love JA, Pleuss N. The first metal-catalyzed intramolecular [5+2] cycloadditions of vinylcyclopropanes and alkenes: Scope, stereochemistry, and asymmetric catalysis Tetrahedron. 54: 7203-7220. DOI: 10.1016/S0040-4020(98)00355-X  1
1998 Wender PA, Smith TE. Transition metal-catalyzed intramolecular [4+2] cycloadditions: Mechanistic and synthetic investigations Tetrahedron. 54: 1255-1275. DOI: 10.1016/S0040-4020(97)10223-X  1
1998 Wender PA, Sperandio D. A New and Selective Catalyst for the [5 + 2] Cycloaddition of Vinylcyclopropanes and Alkynes Journal of Organic Chemistry. 63: 4164-4165.  1
1998 Wender PA, Nagahara K, Dore TM, Ryu I, Komatsu M, Sonoda N. Radical carboxylation: Ester synthesis from alkyl iodides, carbon monoxide, and alcohols under irradiation conditions Chemtracts. 11: 268-273.  1
1998 Wender PA, Martin-Cantalejo Y, Carpenter AJ, Chiu A, De Brabander J, Harran PG, Jimenez JM, Koehler MFT, Lippa B, Morrison JA, Müller SG, Müller SN, Park CM, Shiozaki M, Siedenbiedel C, et al. The chemistry-medicine continuum: Synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads Pure and Applied Chemistry. 70: 539-546.  1
1997 Yang JW, Wender PA. Synthesis of 1-(2-naphthoyl) benzotriazoles as photoactivated DNA cleaving agents. Archives of Pharmacal Research. 20: 197-9. PMID 18975202 DOI: 10.1007/BF02974011  1
1997 Irie K, Yanai Y, Oie K, Ishizawa J, Nakagawa Y, Ohigashi H, Wender PA, Kikkawa U. Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma. Bioorganic & Medicinal Chemistry. 5: 1725-37. PMID 9313873 DOI: 10.1016/S0968-0896(97)00116-8  1
1997 Touami SM, Poon CC, Wender PA. Sequence specific DNA cleavage by conjugates of benzotriazoles and minor groove binders Journal of the American Chemical Society. 119: 7611-7612. DOI: 10.1021/ja971042z  1
1997 Wender PA, Rice KD, Schnute ME. The first formal asymmetry synthesis of phorbol Journal of the American Chemical Society. 119: 7897-7898. DOI: 10.1021/ja9706256  1
1997 Wender PA, Badham NF, Conway SP, Floreancig PE, Glass TE, Houze JB, Krauss NE, Lee D, Marquess DG, McGrane PL, Meng W, Natchus MG, Shuker AJ, Sutton JC, Taylor RE. The pinene path to taxanes. 6. A concise stereocontrolled synthesis of taxol Journal of the American Chemical Society. 119: 2757-2758. DOI: 10.1021/ja963539z  1
1997 Wender PA, Badham NF, Conway SP, Floreancig PE, Glass TE, Granicher C, Houze JB, Janichen J, Lee D, Marquess DG, McGrane PL, Meng W, Mucciaro TP, Muhlebach M, Natchus MG, et al. The pinene path tot taxanes. 5. Stereocontrolled synthesis of a versatile taxane precursor Journal of the American Chemical Society. 119: 2755-2756. DOI: 10.1021/ja9635387  1
1997 Wender PA, Lee D, Lal TK, Horwitz SB, Rao S. Synthesis of novel taxol analogs and evaluation of their biological activities Bioorganic and Medicinal Chemistry Letters. 7: 1941-1944. DOI: 10.1016/S0960-894X(97)00337-5  1
1997 Irie K, Yanai Y, Oie K, Ohigashi H, Wender PA. Protein kinase C regulatory domain surrogate peptides: Effects of metal ions on folding, phorbol ester-binding, and selectivity Bioorganic and Medicinal Chemistry Letters. 7: 965-970. DOI: 10.1016/S0960-894X(97)00140-6  1
1997 Yanai Y, Irie K, Ohigashi H, Wender PA. Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C Bioorganic and Medicinal Chemistry Letters. 7: 117-122. DOI: 10.1016/S0960-894X(96)00587-2  1
1997 Wender PA, Lee D. Enantioselective synthesis of neocarzinostatin chromophore aglycon Chemtracts. 10: 653-660.  1
1997 Harran PG, Wender PA. Alkynylation of C-H bonds via reaction with acetylenic triflones Chemtracts. 10: 522-526.  1
1997 Wender PA, Handy ST, Wright DL. Towards the ideal synthesis Chemistry and Industry (London). X-XI.  1
1997 Wender PA, Nuss JM, Smith DB, Suárez-Sobrino A, Vågberg J, Decosta D, Bordner J. Transition Metal Catalyzed Cycloadditions: An Intramolecular [4 + 4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[a,d]cyclooctene 5-8-5 Ring Systems Journal of Organic Chemistry. 62: 4908-4909.  1
1997 Wender PA, Delong MA, Wireko FC. Novel oxidative rearrangement product of the first trans,cis,cis,cis-[5.5.5.5]fenestrane derivative Acta Crystallographica Section C: Crystal Structure Communications. 53: 954-956.  1
1996 Wender PA, Glass TE, Krauss NE, Mühlebach M, Peschke B, Rawlins DB. The Pinene Path to Taxanes. 4. Approaches to Taxol and Taxol Analogs through Elaboration of Aromatic C-Ring Precursors. The Journal of Organic Chemistry. 61: 7662-7663. PMID 11667717 DOI: 10.1021/jo961289z  1
1996 Irie K, Isaka T, Iwata Y, Yanai Y, Nakamura Y, Koizumi F, Ohigashi H, Wender PA, Satomi Y, Nishino H. Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: Elucidation of the biologically active conformation of the tumor-promoting teleocidins Journal of the American Chemical Society. 118: 10733-10743. DOI: 10.1021/ja961727j  1
1995 Wender PA, Irie K, Miller BL. Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 92: 239-43. PMID 7816824 DOI: 10.1073/pnas.92.1.239  1
1991 Wender PA, Kelly RC, Beckham S, Miller BL. Studies on DNA-cleaving agents: computer modeling analysis of the mechanism of activation and cleavage of dynemicin-oligonucleotide complexes. Proceedings of the National Academy of Sciences of the United States of America. 88: 8835-9. PMID 1924343 DOI: 10.1073/pnas.88.19.8835  1
1988 Wender PA, Cribbs CM, Koehler KF, Sharkey NA, Herald CL, Kamano Y, Pettit GR, Blumberg PM. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 85: 7197-201. PMID 3174627  1
1986 Wender PA, Koehler KF, Sharkey NA, Dell'Aquila ML, Blumberg PM. Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proceedings of the National Academy of Sciences of the United States of America. 83: 4214-8. PMID 3086877  1
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