Kuang Shen - Publications

Affiliations: 
2013 Chemistry California Institute of Technology, Pasadena, CA 

27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM. Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell. PMID 31704029 DOI: 10.1016/j.cell.2019.10.036  1
2019 Shen K, Valenstein ML, Gu X, Sabatini DM. Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. The Journal of Biological Chemistry. PMID 30651352 DOI: 10.1074/jbc.AC119.007382  1
2018 Shen K, Sabatini DM. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 115: 9545-9550. PMID 30181260 DOI: 10.1073/pnas.1811727115  1
2018 Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature. PMID 29590090 DOI: 10.1038/nature26158  1
2017 Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Molecular Cell. 68: 821. PMID 29149601 DOI: 10.1016/j.molcel.2017.10.031  1
2017 Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Molecular Cell. PMID 29056322 DOI: 10.1016/j.molcel.2017.09.026  1
2017 Hwang Fu YH, Huang WYC, Shen K, Groves JT, Miller T, Shan SO. Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting. Elife. 6. PMID 28753124 DOI: 10.7554/eLife.25885  1
2017 Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. PMID 28199306 DOI: 10.1038/nature21423  1
2016 Chen Y, Shen K, Shan SO, Kou SC. Analyzing Single-Molecule Protein Transportation Experiments via Hierarchical Hidden Markov Models. Journal of the American Statistical Association. 111: 951-966. PMID 28943680 DOI: 10.1080/01621459.2016.1140050  1
2016 Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. PMID 26972053 DOI: 10.1016/j.cell.2016.02.035  1
2016 Shen K, Yu Z, Jiang Z. An optimization mechanism for mid-bond testing of TSV-based 3D SoCs Ieice Transactions On Electronics. 308-315. DOI: 10.1587/transele.E99.C.308  0.48
2016 Wang X, Liu H, Yu Z, Shen K. A novel two-phase heuristic for application mapping onto mesh-based network-on-chip Ieice Electronics Express. 13. DOI: 10.1587/elex.13.20151097  0.48
2016 Yu Z, Wang X, Shen K. Conditional forwarding: simple flow control to increase adaptivity for fully adaptive routing algorithms Journal of Supercomputing. 1-15. DOI: 10.1007/s11227-015-1597-3  0.48
2015 Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science (New York, N.Y.). PMID 26449471 DOI: 10.1126/science.aab2674  1
2015 Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science (New York, N.Y.). 347: 188-94. PMID 25567906 DOI: 10.1126/science.1257132  1
2015 Wang X, Yu Z, Shen K, Wang M. An innovative routing scheme to reduce communication delay in DMesh networks Ieice Electronics Express. 12: 1-11. DOI: 10.1587/elex.12.20150353  0.48
2014 Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discovery. 4: 554-63. PMID 24631838 DOI: 10.1158/2159-8290.CD-13-0929  1
2013 Voigts-Hoffmann F, Schmitz N, Shen K, Shan SO, Ataide SF, Ban N. The structural basis of FtsY recruitment and GTPase activation by SRP RNA. Molecular Cell. 52: 643-54. PMID 24211265 DOI: 10.1016/j.molcel.2013.10.005  1
2013 Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO. Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end. The Journal of Biological Chemistry. 288: 36385-97. PMID 24151069 DOI: 10.1074/jbc.M113.513614  1
2013 Jaru-Ampornpan P, Liang FC, Nisthal A, Nguyen TX, Wang P, Shen K, Mayo SL, Shan SO. Mechanism of an ATP-independent protein disaggregase: II. distinct molecular interactions drive multiple steps during aggregate disassembly. The Journal of Biological Chemistry. 288: 13431-45. PMID 23519468 DOI: 10.1074/jbc.M113.462861  1
2013 Akopian D, Shen K, Zhang X, Shan SO. Signal recognition particle: an essential protein-targeting machine. Annual Review of Biochemistry. 82: 693-721. PMID 23414305 DOI: 10.1146/annurev-biochem-072711-164732  1
2013 Akopian D, Dalal K, Shen K, Duong F, Shan SO. SecYEG activates GTPases to drive the completion of cotranslational protein targeting. The Journal of Cell Biology. 200: 397-405. PMID 23401005 DOI: 10.1083/jcb.201208045  1
2012 Shen K, Arslan S, Akopian D, Ha T, Shan SO. Activated GTPase movement on an RNA scaffold drives co-translational protein targeting. Nature. 492: 271-5. PMID 23235881 DOI: 10.1038/nature11726  1
2011 Shen K, Zhang X, Shan SO. Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting. Rna (New York, N.Y.). 17: 892-902. PMID 21460239 DOI: 10.1261/rna.2610411  1
2011 Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N. The crystal structure of the signal recognition particle in complex with its receptor. Science (New York, N.Y.). 331: 881-6. PMID 21330537 DOI: 10.1126/science.1196473  1
2010 Jaru-Ampornpan P, Shen K, Lam VQ, Ali M, Doniach S, Jia TZ, Shan SO. ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit. Nature Structural & Molecular Biology. 17: 696-702. PMID 20424608 DOI: 10.1038/nsmb.1836  1
2010 Shen K, Shan SO. Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting. Proceedings of the National Academy of Sciences of the United States of America. 107: 7698-703. PMID 20385832 DOI: 10.1073/pnas.1002968107  1
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