Year |
Citation |
Score |
2023 |
Tettoni SD, Egri SB, Doxsey DD, Veinotte K, Ouch C, Chang JY, Song K, Xu C, Shen K. Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing. Structure (London, England : 1993). PMID 37453417 DOI: 10.1016/j.str.2023.06.012 |
0.348 |
|
2022 |
Doxsey DD, Veinotte K, Shen K. A New Crosslinking Assay to Study Guanine Nucleotide Binding in the Gtr Heterodimer of . Small Gtpases. 13: 327-334. PMID 36328771 DOI: 10.1080/21541248.2022.2141019 |
0.301 |
|
2022 |
Doxsey DD, Shen K. Purification and biochemical characterization of the Rag GTPase heterodimer. Methods in Enzymology. 675: 131-158. PMID 36220268 DOI: 10.1016/bs.mie.2022.07.007 |
0.319 |
|
2022 |
Egri S, Ouch C, Chou HT, Yu Z, Song K, Xu C, Shen K. Cryo-EM structures of the Human GATOR1-Rag-Ragulator Complex Reveal a Spatial-Constraint Regulated GAP Mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 35552818 DOI: 10.1096/fasebj.2022.36.S1.R1985 |
0.322 |
|
2022 |
Egri SB, Ouch C, Chou HT, Yu Z, Song K, Xu C, Shen K. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Molecular Cell. PMID 35338845 DOI: 10.1016/j.molcel.2022.03.002 |
0.321 |
|
2021 |
Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona F, Dafinger C, Houillier P, Jones D, Kleinerüschkamp F, Oh J, Godefroid N, Eltan M, Güran T, Burtey S, Parotte MC, et al. mTOR-Activating Mutations in RRAGD are Causative for Kidney Tubulopathy and Cardiomyopathy. Journal of the American Society of Nephrology : Jasn. PMID 34607910 DOI: 10.1681/ASN.2021030333 |
0.473 |
|
2020 |
Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, ... ... Shen K, et al. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell. PMID 32991842 DOI: 10.1016/J.Cell.2020.09.032 |
0.353 |
|
2019 |
Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM. Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell. PMID 31704029 DOI: 10.1016/J.Cell.2019.10.036 |
0.758 |
|
2019 |
Rasheed N, Lima TB, Mercaldi GF, Nascimento AFZ, Silva ALS, Righetto GL, Bar-Peled L, Shen K, Sabatini Shen DM, Gozzo FC, Aparicio R, Smetana JHC. C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly. Febs Open Bio. PMID 31314152 DOI: 10.1002/2211-5463.12700 |
0.308 |
|
2019 |
Shen K, Valenstein ML, Gu X, Sabatini DM. Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. The Journal of Biological Chemistry. PMID 30651352 DOI: 10.1074/Jbc.Ac119.007382 |
0.623 |
|
2018 |
Heo JM, Ordureau A, Swarup S, Paulo JA, Shen K, Sabatini DM, Harper JW. RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway. Science Advances. 4: eaav0443. PMID 30627666 DOI: 10.1126/Sciadv.Aav0443 |
0.601 |
|
2018 |
Shen K, Sabatini DM. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 115: 9545-9550. PMID 30181260 DOI: 10.1073/Pnas.1811727115 |
0.573 |
|
2018 |
Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature. PMID 29590090 DOI: 10.1038/Nature26158 |
0.639 |
|
2017 |
Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Molecular Cell. 68: 821. PMID 29149601 DOI: 10.1016/j.molcel.2017.10.031 |
0.435 |
|
2017 |
Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Molecular Cell. PMID 29056322 DOI: 10.1016/J.Molcel.2017.09.026 |
0.579 |
|
2017 |
Hwang Fu YH, Huang WYC, Shen K, Groves JT, Miller T, Shan SO. Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting. Elife. 6. PMID 28753124 DOI: 10.1016/J.Bpj.2017.11.1170 |
0.635 |
|
2017 |
Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. PMID 28199306 DOI: 10.1038/Nature21423 |
0.756 |
|
2017 |
Fu YH, Huang WYC, Shen K, Groves JT, Miller T, Shan S. Author response: Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting Elife. DOI: 10.7554/Elife.25885.026 |
0.674 |
|
2016 |
Chen Y, Shen K, Shan SO, Kou SC. Analyzing Single-Molecule Protein Transportation Experiments via Hierarchical Hidden Markov Models. Journal of the American Statistical Association. 111: 951-966. PMID 28943680 DOI: 10.1080/01621459.2016.1140050 |
0.592 |
|
2016 |
Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. PMID 26972053 DOI: 10.1016/J.Cell.2016.02.035 |
0.623 |
|
2015 |
Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science (New York, N.Y.). PMID 26449471 DOI: 10.1126/Science.Aab2674 |
0.621 |
|
2015 |
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science (New York, N.Y.). 347: 188-94. PMID 25567906 DOI: 10.1126/Science.1257132 |
0.589 |
|
2014 |
Diaz-Muñoz G, Harchar TA, Lai TP, Shen KF, Hopper AK. Requirement of the spindle pole body for targeting and/or tethering proteins to the inner nuclear membrane. Nucleus (Austin, Tex.). 5: 352-66. PMID 25482124 DOI: 10.4161/Nucl.29793 |
0.341 |
|
2014 |
Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discovery. 4: 554-63. PMID 24631838 DOI: 10.1158/2159-8290.CD-13-0929 |
0.644 |
|
2013 |
Voigts-Hoffmann F, Schmitz N, Shen K, Shan SO, Ataide SF, Ban N. The structural basis of FtsY recruitment and GTPase activation by SRP RNA. Molecular Cell. 52: 643-54. PMID 24211265 DOI: 10.1016/J.Molcel.2013.10.005 |
0.629 |
|
2013 |
Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO. Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end. The Journal of Biological Chemistry. 288: 36385-97. PMID 24151069 DOI: 10.1074/Jbc.M113.513614 |
0.604 |
|
2013 |
Jaru-Ampornpan P, Liang FC, Nisthal A, Nguyen TX, Wang P, Shen K, Mayo SL, Shan SO. Mechanism of an ATP-independent protein disaggregase: II. distinct molecular interactions drive multiple steps during aggregate disassembly. The Journal of Biological Chemistry. 288: 13431-45. PMID 23519468 DOI: 10.1074/Jbc.M113.462861 |
0.772 |
|
2013 |
Akopian D, Shen K, Zhang X, Shan SO. Signal recognition particle: an essential protein-targeting machine. Annual Review of Biochemistry. 82: 693-721. PMID 23414305 DOI: 10.1146/Annurev-Biochem-072711-164732 |
0.743 |
|
2013 |
Akopian D, Dalal K, Shen K, Duong F, Shan SO. SecYEG activates GTPases to drive the completion of cotranslational protein targeting. The Journal of Cell Biology. 200: 397-405. PMID 23401005 DOI: 10.1083/Jcb.201208045 |
0.741 |
|
2013 |
Shen K, Arslan S, Akopian D, Ha T, Shan S. Activated GTPase Movement on SRP RNA Drives Cotranslational Protein Targeting Biophysical Journal. 104: 419a. DOI: 10.1016/J.Bpj.2012.11.2334 |
0.728 |
|
2012 |
Shen K, Arslan S, Akopian D, Ha T, Shan SO. Activated GTPase movement on an RNA scaffold drives co-translational protein targeting. Nature. 492: 271-5. PMID 23235881 DOI: 10.1038/Nature11726 |
0.74 |
|
2011 |
Shen K, Zhang X, Shan SO. Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting. Rna (New York, N.Y.). 17: 892-902. PMID 21460239 DOI: 10.1261/Rna.2610411 |
0.638 |
|
2011 |
Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N. The crystal structure of the signal recognition particle in complex with its receptor. Science (New York, N.Y.). 331: 881-6. PMID 21330537 DOI: 10.1126/Science.1196473 |
0.641 |
|
2010 |
Jaru-Ampornpan P, Shen K, Lam VQ, Ali M, Doniach S, Jia TZ, Shan SO. ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit. Nature Structural & Molecular Biology. 17: 696-702. PMID 20424608 DOI: 10.1038/Nsmb.1836 |
0.782 |
|
2010 |
Shen K, Shan SO. Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting. Proceedings of the National Academy of Sciences of the United States of America. 107: 7698-703. PMID 20385832 DOI: 10.1073/Pnas.1002968107 |
0.624 |
|
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