| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2024 | Maurin L, Marselli L, Boissel M, Ning L, Boutry R, Fernandes J, Suleiman M, De Luca C, Leloire A, Pascat V, Toussaint B, Amanzougarene S, Derhourhi M, Jörns A, Lenzen S, ... ... Froguel P, et al. PNLIPRP1 hypermethylation in exocrine pancreas links type 2 diabetes and cholesterol metabolism. Diabetes. PMID 39137110 DOI: 10.2337/db24-0215 | 0.54 | |||
| 2024 | Meulebrouck S, Merrheim J, Queniat G, Bourouh C, Derhourhi M, Boissel M, Yi X, Badreddine A, Boutry R, Leloire A, Toussaint B, Amanzougarene S, Vaillant E, Durand E, Loiselle H, ... ... Froguel P, et al. Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function. Nature Communications. 15: 6627. PMID 39103322 DOI: 10.1038/s41467-024-51004-6 | 0.573 | |||
| 2024 | Le Collen L, Froguel P, Bonnefond A. Towards the recognition of oligogenic forms of type 2 diabetes. Trends in Endocrinology and Metabolism: Tem. PMID 38955653 DOI: 10.1016/j.tem.2024.06.006 | 0.55 | |||
| 2024 | Pascat V, Zudina L, Ulrich A, Maina JG, Kaakinen M, Pupko I, Bonnefond A, Demirkan A, Balkhiyarova Z, Froguel P, Prokopenko I. comorbidPGS: an R package assessing shared predisposition between Phenotypes using Polygenic Scores. Human Heredity. PMID 38740014 DOI: 10.1159/000539325 | 0.505 | |||
| 2024 | Hu M, Kim I, Morán I, Peng W, Sun O, Bonnefond A, Khamis A, Bonàs-Guarch S, Froguel P, Rutter GA. Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 38: e23610. PMID 38661000 DOI: 10.1096/fj.202301700RR | 0.587 | |||
| 2024 | Burrows K, Heiskala A, Bradfield JP, Balkhiyarova Z, Ning L, Boissel M, Chan YM, Froguel P, Bonnefond A, Hakonarson H, Alves AC, Lawlor DA, Kaakinen M, Järvelin MR, Grant SFA, et al. A framework for conducting time-varying genome-wide association studies: An application to body mass index across childhood in six multiethnic cohorts. Medrxiv : the Preprint Server For Health Sciences. PMID 38559031 DOI: 10.1101/2024.03.13.24304263 | 0.519 | |||
| 2024 | Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, ... ... Froguel P, et al. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature. PMID 38374256 DOI: 10.1038/s41586-024-07019-6 | 0.568 | |||
| 2024 | Folon L, Baron M, Scherrer V, Toussaint B, Vaillant E, Loiselle H, Dechaume A, De Pooter F, Boutry R, Boissel M, Diallo A, Ning L, Balkau B, Charpentier G, Franc S, ... ... Froguel P, et al. Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes. Diabetes Care. PMID 38170957 DOI: 10.2337/dc23-1851 | 0.598 | |||
| 2023 | Dance A, Fernandes J, Toussaint B, Vaillant E, Boutry R, Baron M, Loiselle H, Balkau B, Charpentier G, Franc S, Ibberson M, Marre M, Gernay M, Fadeur M, Paquot N, ... ... Froguel P, et al. Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics. Molecular Metabolism. 101867. PMID 38159881 DOI: 10.1016/j.molmet.2023.101867 | 0.54 | |||
| 2023 | Kouidrat Y, Collen LL, Vaxillaire M, Dechaume A, Toussaint B, Vaillant E, Amanzougarene S, Derhourhi M, Delemer B, Azahaf M, Froguel P, Bonnefond A. Dominant PDX1 deficiency causes highly penetrant diabetes at different ages, associated with obesity and exocrine pancreatic deficiency: lessons for precision medicine. Diabetes & Metabolism. 101507. PMID 38141807 DOI: 10.1016/j.diabet.2023.101507 | 0.575 | |||
| 2023 | Johanns M, Haas JT, Raverdy V, Vandel J, Chevalier-Dubois J, Guille L, Derudas B, Legendre B, Caiazzo R, Verkindt H, Gnemmi V, Leteurtre E, Derhourhi M, Bonnefond A, Froguel P, et al. Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD. Jhep Reports : Innovation in Hepatology. 6: 100948. PMID 38125300 DOI: 10.1016/j.jhepr.2023.100948 | 0.447 | |||
| 2023 | Meulebrouck S, Scherrer V, Boutry R, Toussaint B, Vaillant E, Dechaume A, Loiselle H, Balkau B, Charpentier G, Franc S, Marre M, Baron M, Vaxillaire M, Derhourhi M, Boissel M, ... Froguel P, et al. Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas. Diabetologia. PMID 38051360 DOI: 10.1007/s00125-023-06035-x | 0.592 | |||
| 2023 | de Las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ, Munroe PB, Miller CL, Aschard H, Aslibekyan S, Bartz TM, Bielak LF, Chai JF, Cheng CY, Dorajoo R, ... ... Froguel P, et al. Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci. Frontiers in Genetics. 14: 1235337. PMID 38028628 DOI: 10.3389/fgene.2023.1235337 | 0.499 | |||
| 2023 | Fumeron F, Velho G, Alzaid F, El Boustany R, Vandiedonck C, Bonnefond A, Froguel P, Potier L, Marre M, Balkau B, Roussel R, Venteclef N. Genetic variants of interferon-response factor 5 are associated with the incidence of chronic kidney disease: the D.E.S.I.R. study. Genes and Immunity. 24: 303-308. PMID 37978231 DOI: 10.1038/s41435-023-00229-4 | 0.484 | |||
| 2023 | Gao W, Liu L, Huh E, Gbahou F, Cecon E, Oshima M, Houzé L, Katsonis P, Hegron A, Fan Z, Hou G, Charpentier G, Boissel M, Derhourhi M, Marre M, ... ... Froguel P, et al. Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity. Nature Metabolism. PMID 37709961 DOI: 10.1038/s42255-023-00889-6 | 0.59 | |||
| 2023 | Saeed S, Khanam R, Janjua QM, Manzoor J, Ning L, Hanook S, Canouil M, Ali M, Ayesha H, Khan WI, Farooqi IS, Yeo GSH, O'Rahilly S, Bonnefond A, Butt TA, ... ... Froguel P, et al. High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor. Cell Reports. Medicine. 101187. PMID 37659411 DOI: 10.1016/j.xcrm.2023.101187 | 0.47 | |||
| 2023 | Orioli L, Canouil M, Sawadogo K, Ning L, Deldicque L, Lause P, de Barsy M, Froguel P, Loumaye A, Deswysen Y, Navez B, Bonnefond A, Thissen JP. Identification of myokines susceptible to improve glucose homeostasis after bariatric surgery. European Journal of Endocrinology. 189: 409-421. PMID 37638789 DOI: 10.1093/ejendo/lvad122 | 0.509 | |||
| 2023 | Hu M, Bonas-Guarch S, Kim I, Morán I, Peng W, Bonnefond A, Khamis A, Froguel P, Rutter GA. Multiple genetic variants at the locus affect a local super-enhancer cluster to influence pancreatic β-cell survival and function. Biorxiv : the Preprint Server For Biology. PMID 37502937 DOI: 10.1101/2023.07.13.548906 | 0.564 | |||
| 2023 | Oger F, Moreno M, Derhourhi M, Thiroux B, Berberian L, Bourouh C, Durand E, Amanzougarene S, Badreddine A, Blanc E, Molendi-Coste O, Pineau L, Pasquetti G, Rolland L, Carney C, ... ... Froguel P, et al. Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogramming. Iscience. 26: 107231. PMID 37496675 DOI: 10.1016/j.isci.2023.107231 | 0.481 | |||
| 2023 | Maina JG, Balkhiyarova Z, Nouwen A, Pupko I, Ulrich A, Boissel M, Bonnefond A, Froguel P, Khamis A, Prokopenko I, Kaakinen M. Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes. Diabetes Care. PMID 37494602 DOI: 10.2337/dc22-2373 | 0.527 | |||
| 2023 | Oger F, Bourouh C, Friano ME, Courty E, Rolland L, Gromada X, Moreno M, Carney C, Rabhi N, Durand E, Amanzougarene S, Berberian L, Derhourhi M, Blanc E, Hannou SA, ... ... Froguel P, et al. β-cell specific E2f1 deficiency impairs glucose homeostasis, β-cell identity and insulin secretion. Diabetes. PMID 37216637 DOI: 10.2337/db22-0604 | 0.496 | |||
| 2023 | Maina JG, Pascat V, Zudina L, Ulrich A, Pupko I, Bonnefond A, Balkhiyarova Z, Kaakinen M, Froguel P, Prokopenko I. Abdominal obesity is a more important causal risk factor for pancreatic cancer than overall obesity. European Journal of Human Genetics : Ejhg. PMID 37161092 DOI: 10.1038/s41431-023-01301-3 | 0.529 | |||
| 2023 | Le Collen L, Delemer B, Poitou C, Vaxillaire M, Toussaint B, Dechaume A, Badreddine A, Boissel M, Derhourhi M, Clément K, Petit JM, Mau-Them FT, Bruel AL, Thauvin-Robinet C, Saveanu A, ... ... Froguel P, et al. Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: implication for MC4R agonist use. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 100857. PMID 37092539 DOI: 10.1016/j.gim.2023.100857 | 0.549 | |||
| 2023 | Saeed S, Ning L, Badreddine A, Mirza MU, Boissel M, Khanam R, Manzoor J, Janjua QM, Khan WI, Toussaint B, Vaillant E, Amanzougarene S, Derhourhi M, Trant JF, Siegert AM, ... ... Froguel P, et al. Biallelic mutations in P4HTM cause syndromic obesity. Diabetes. PMID 37083980 DOI: 10.2337/db22-1017 | 0.56 | |||
| 2023 | Xiao J, El Eid L, Buenaventura T, Boutry R, Bonnefond A, Jones B, Rutter GA, Froguel P, Tomas A. Control of human pancreatic beta cell kinome by GLP-1R biased agonism. Diabetes, Obesity & Metabolism. PMID 37039251 DOI: 10.1111/dom.15083 | 0.453 | |||
| 2023 | Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Rayner NW, Bocher O, Ana Luiza de SVA, Sonehara K, Namba S, Lee SSK, Preuss MH, ... ... Froguel P, et al. Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications. Medrxiv : the Preprint Server For Health Sciences. PMID 37034649 DOI: 10.1101/2023.03.31.23287839 | 0.575 | |||
| 2023 | Kahoul Y, Yao X, Oger F, Moreno M, Amanzougarene S, Derhourhi M, Durand E, Boutry R, Bonnefond A, Froguel P, Dani C, Annicotte JS, Breton C. Knocking Down in 3D hiPSC-Derived Brown Adipose Progenitors Potentiates Differentiation, Oxidative Metabolism and Browning Process. Cells. 12. PMID 36980212 DOI: 10.3390/cells12060870 | 0.487 | |||
| 2023 | Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, et al. A rare human variant that disrupts GPR10 signalling causes weight gain in mice. Nature Communications. 14: 1450. PMID 36922513 DOI: 10.1038/s41467-023-36966-3 | 0.524 | |||
| 2023 | Bonnefond A, Unnikrishnan R, Doria A, Vaxillaire M, Kulkarni RN, Mohan V, Trischitta V, Froguel P. Monogenic diabetes. Nature Reviews. Disease Primers. 9: 12. PMID 36894549 DOI: 10.1038/s41572-023-00421-w | 0.575 | |||
| 2023 | Folon L, Baron M, Toussaint B, Vaillant E, Boissel M, Scherrer V, Loiselle H, Leloire A, Badreddine A, Balkau B, Charpentier G, Franc S, Marre M, Aboulouard S, Salzet M, ... ... Froguel P, et al. Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study. The Lancet. Diabetes & Endocrinology. 11: 182-190. PMID 36822744 DOI: 10.1016/S2213-8587(22)00392-8 | 0.569 | |||
| 2022 | Froguel P, Bonnefond A. The discovery of human agouti-induced obesity and its implication for genetic diagnosis. Nature Metabolism. 4: 1614-1615. PMID 36536131 DOI: 10.1038/s42255-022-00695-6 | 0.538 | |||
| 2022 | Bourouh C, Courty E, Rolland L, Pasquetti G, Gromada X, Rabhi N, Carney C, Moreno M, Boutry R, Caron E, Benfodda Z, Meffre P, Kerr-Conte J, Pattou F, Froguel P, et al. The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells. Cell Reports. 40: 111170. PMID 35947949 DOI: 10.1016/j.celrep.2022.111170 | 0.516 | |||
| 2022 | Pelletier A, Carrier A, Zhao Y, Canouil M, Derhourhi M, Durand E, Berberian-Ferrato L, Greally J, Hughes F, Froguel P, Bonnefond A, Delahaye F. Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates. International Journal of Molecular Sciences. 23. PMID 35806330 DOI: 10.3390/ijms23137323 | 0.462 | |||
| 2022 | Lemaitre M, Douillard C, Froguel P, Bonnefond A, Vambergue A. Management of pregnancy in a patient with congenital hyperinsulinism treated with association of diazoxide/calcium channel blocker. Acta Diabetologica. PMID 35624321 DOI: 10.1007/s00592-022-01898-9 | 0.429 | |||
| 2022 | Khamis A, Ning L, Balkau B, Bonnefond A, Canouil M, Roussel R, Froguel P. Epigenetic changes associated with hyperglycaemia exposure in the longitudinal D.E.S.I.R. cohort. Diabetes & Metabolism. 48: 101347. PMID 35427775 DOI: 10.1016/j.diabet.2022.101347 | 0.487 | |||
| 2022 | Le Collen L, Delemer B, Spodenkiewicz M, Cornillet Lefebvre P, Durand E, Vaillant E, Badreddine A, Derhourhi M, Mouhoub TA, Jouret G, Juttet P, Souchon PF, Vaxillaire M, Froguel P, Bonnefond A, et al. Compound genetic etiology in a patient with a syndrome including diabetes, intellectual deficiency and distichiasis. Orphanet Journal of Rare Diseases. 17: 86. PMID 35227307 DOI: 10.1186/s13023-022-02248-2 | 0.562 | |||
| 2022 | Pervjakova N, Moen GH, Borges MC, Ferreira T, Cook JP, Allard C, Beaumont RN, Canouil M, Hatem G, Heiskala A, Joensuu A, Karhunen V, Kwak SH, Lin FTJ, Liu J, ... ... Froguel P, et al. Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Human Molecular Genetics. PMID 35220425 DOI: 10.1093/hmg/ddac050 | 0.578 | |||
| 2022 | Cornière N, Thomson RB, Thauvin S, Villoutreix BO, Karp S, Dynia DW, Burlein S, Brinkmann L, Badreddine A, Dechaume A, Derhourhi M, Durand E, Vaillant E, Froguel P, Chambrey R, et al. Dominant negative mutation in oxalate transporter associated with enteric hyperoxaluria and nephrolithiasis. Journal of Medical Genetics. PMID 35115415 DOI: 10.1136/jmedgenet-2021-108256 | 0.497 | |||
| 2022 | Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong MG, Musholt PB, ... ... Froguel P, et al. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Reports. Medicine. 3: 100477. PMID 35106505 DOI: 10.1016/j.xcrm.2021.100477 | 0.572 | |||
| 2022 | Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, ... ... Froguel P, et al. Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies. Diabetes Care. PMID 35104326 DOI: 10.2337/dc21-1701 | 0.448 | |||
| 2022 | Saeed S, Janjua QM, Haseeb A, Khanam R, Durand E, Vaillant E, Ning L, Badreddine A, Berberian L, Boissel M, Amanzougarene S, Canouil M, Derhourhi M, Bonnefond A, Arslan M, ... Froguel P, et al. Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan. Diabetes. PMID 35061034 DOI: 10.2337/db21-0373 | 0.585 | |||
| 2022 | Bornaque F, Delannoy CP, Courty E, Rabhi N, Carney C, Rolland L, Moreno M, Gromada X, Bourouh C, Petit P, Durand E, Pattou F, Kerr-Conte J, Froguel P, Bonnefond A, et al. Glucose Regulates mA Methylation of RNA in Pancreatic Islets. Cells. 11. PMID 35053407 DOI: 10.3390/cells11020291 | 0.54 | |||
| 2021 | Jungtrakoon Thamtarana P, Marucci A, Pannone L, Bonnefond A, Pezzilli S, Biagini T, Buranasupkajorn P, Hastings T, Mendonca C, Marselli L, Di Paola R, Abubakar Z, Mercuri L, Alberico F, Flex E, ... ... Froguel P, et al. Gain of function of Malate Dehydrogenase 2 (MDH2) and familial hyperglycemia. The Journal of Clinical Endocrinology and Metabolism. PMID 34718610 DOI: 10.1210/clinem/dgab790 | 0.573 | |||
| 2021 | Hegron A, Huh E, Deupi X, Sokrat B, Gao W, Le Gouill C, Canouil M, Boissel M, Charpentier G, Roussel R, Balkau B, Froguel P, Plouffe B, Bonnefond A, Lichtarge O, et al. Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants. Acs Pharmacology & Translational Science. 4: 1614-1627. PMID 34661078 DOI: 10.1021/acsptsci.1c00157 | 0.49 | |||
| 2021 | Canouil M, Khamis A, Keikkala E, Hummel S, Lobbens S, Bonnefond A, Delahaye F, Tzala E, Mustaniemi S, Vääräsmäki M, Jarvelin MR, Sebert S, Kajantie E, Froguel P, Andrew T. Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome. Diabetes Care. PMID 34116986 DOI: 10.2337/dc20-2960 | 0.57 | |||
| 2021 | Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, ... ... Froguel P, et al. Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nature Communications. 12: 995. PMID 33558525 DOI: 10.1038/s41467-021-21276-3 | 0.508 | |||
| 2021 | Bonnefond A, Froguel P. Clustering for a better prediction of type 2 diabetes mellitus. Nature Reviews. Endocrinology. PMID 33526906 DOI: 10.1038/s41574-021-00475-4 | 0.514 | |||
| 2021 | Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, ... ... Froguel P, et al. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nature Communications. 12: 24. PMID 33402679 DOI: 10.1038/s41467-020-19366-9 | 0.515 | |||
| 2020 | Vaxillaire M, Bonnefond A, Liatis S, Ben Salem Hachmi L, Jotic A, Boissel M, Gaget S, Durand E, Vaillant E, Derhourhi M, Canouil M, Larcher N, Allegaert F, Medlej R, Chadli A, ... ... Froguel P, et al. Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries. Diabetes Research and Clinical Practice. 108553. PMID 33242514 DOI: 10.1016/j.diabres.2020.108553 | 0.539 | |||
| 2020 | Imam A, Winnebeck EC, Buchholz N, Froguel P, Bonnefond A, Solimena M, Ivanova A, Bouvier M, Plouffe B, Charpentier G, Karamitri A, Jockers R, Roenneberg T, Vetter C. Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study. Frontiers in Physiology. 11: 564140. PMID 33162895 DOI: 10.3389/fphys.2020.564140 | 0.522 | |||
| 2020 | Bonnefond A, Boissel M, Bolze A, Durand E, Toussaint B, Vaillant E, Gaget S, Graeve F, Dechaume A, Allegaert F, Guilcher DL, Yengo L, Dhennin V, Borys JM, Lu JT, ... ... Froguel P, et al. Pathogenic variants in actionable MODY genes are associated with type 2 diabetes. Nature Metabolism. 2: 1126-1134. PMID 33046911 DOI: 10.1038/s42255-020-00294-3 | 0.602 | |||
| 2020 | Baron M, Froguel P, Bonnefond A. [Something new in the genetics of monogenic obesity and its insights into pathophysiology]. Medecine Sciences : M/S. 36: 859-865. PMID 33026327 DOI: 10.1051/medsci/2020156 | 0.549 | |||
| 2020 | Kahoul Y, Oger F, Montaigne J, Froguel P, Breton C, Annicotte JS. Emerging Roles for the () Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes. Biomolecules. 10. PMID 32971832 DOI: 10.3390/biom10091350 | 0.309 | |||
| 2020 | Jacob A, Pasquier J, Carapito R, Auradé F, Molitor A, Froguel P, Fakhro K, Halabi N, Viot G, Bahram S, Rafii A. A de novo synonymous variant in EFTUD2 disrupts normal splicing and causes mandibulofacial dysostosis with microcephaly: case report. Bmc Medical Genetics. 21: 182. PMID 32943010 DOI: 10.1186/S12881-020-01121-Y | 0.31 | |||
| 2020 | Lemoine S, Eladari D, Juillard L, Bonnefond A, Froguel P, Dubourg L. The Case | Hypokalemia and severe renal loss of sodium. Kidney International. 97: 1305-1306. PMID 32444101 DOI: 10.1016/J.Kint.2019.12.022 | 0.484 | |||
| 2020 | Khamis A, Boutry R, Canouil M, Mathew S, Lobbens S, Crouch H, Andrew T, Abderrahmani A, Tamanini F, Froguel P. Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect. Clinical Epigenetics. 12: 68. PMID 32410704 DOI: 10.1186/S13148-020-00858-W | 0.667 | |||
| 2020 | Saeed S, Arslan M, Manzoor J, Din SM, Janjua QM, Ayesha H, Ain QT, Inam L, Lobbens S, Vaillant E, Durand E, Derhourhi M, Amanzougarene S, Badreddine A, Berberian L, ... ... Froguel P, et al. Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence (≥49%) in an Inbred Population of Pakistan. Diabetes. PMID 32349990 DOI: 10.2337/Db19-1238 | 0.62 | |||
| 2020 | El Shamieh S, Stathopoulou MG, Bonnefond A, Ndiaye NC, Lecoeur C, Meyre D, Dadé S, Chedid P, Salami A, Shahabi P, Dedoussis GV, Froguel P, Visvikis-Siest S. Obesity status modifies the association between rs7556897T>C in the intergenic region SLC19A3-CCL20 and blood pressure in French children. Clinical Chemistry and Laboratory Medicine. PMID 32238601 DOI: 10.1515/Cclm-2019-0292 | 0.591 | |||
| 2020 | Tenenbaum M, Plaisance V, Boutry R, Pawlowski V, Jacovetti C, Sanchez-Parra C, Ezanno H, Bourry J, Beeler N, Pasquetti G, Gmyr V, Dalle S, Kerr-Conte J, Pattou F, Hirai SI, ... ... Froguel P, et al. The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development. Cellular and Molecular Life Sciences : Cmls. PMID 32189007 DOI: 10.1007/S00018-020-03499-7 | 0.717 | |||
| 2020 | Imam A, Winnebeck EC, Buchholz N, Froguel P, Bonnefond A, Solimena M, Ivanova A, Bouvier M, Plouffe B, Charpentier G, Karamitri A, Jockers R, Roenneberg T, Vetter C. Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study Frontiers in Physiology. 11. DOI: 10.3389/fphys.2020.564140 | 0.526 | |||
| 2019 | Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, Clavel MA, Arsenault BJ, Boureau AS, Lecointe S, Baron E, ... ... Froguel P, et al. Genetic Association Analyses Highlight , , and As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis. Circulation. Genomic and Precision Medicine. 12: e002617. PMID 32141789 DOI: 10.1161/CIRCGEN.119.002617 | 0.488 | |||
| 2019 | Meyre D, Andress EJ, Sharma T, Snippe M, Asif H, Maharaj A, Vatin V, Gaget S, Besnard P, Choquet H, Froguel P, Linton KJ. Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications. Scientific Reports. 9: 17123. PMID 31748580 DOI: 10.1038/S41598-019-53388-8 | 0.344 | |||
| 2019 | Baron M, Maillet J, Huyvaert M, Dechaume A, Boutry R, Loiselle H, Durand E, Toussaint B, Vaillant E, Philippe J, Thomas J, Ghulam A, Franc S, Charpentier G, Borys JM, ... ... Froguel P, et al. Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension. Nature Medicine. PMID 31700171 DOI: 10.1038/S41591-019-0622-0 | 0.768 | |||
| 2019 | Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, ... ... Froguel P, et al. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. Bmc Cardiovascular Disorders. 19: 240. PMID 31664920 DOI: 10.1186/S12872-019-1187-Z | 0.552 | |||
| 2019 | Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N, Wang CA, ... ... Froguel P, et al. A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity. Human Molecular Genetics. PMID 31504550 DOI: 10.1093/Hmg/Ddz161 | 0.623 | |||
| 2019 | Canouil M, Bouland GA, Bonnefond A, Froguel P, 't Hart LM, Slieker RC. NACHO: an R package for quality control of NanoString nCounter data. Bioinformatics (Oxford, England). PMID 31504159 DOI: 10.1093/Bioinformatics/Btz647 | 0.496 | |||
| 2019 | Ndiaye FK, Huyvaert M, Ortalli A, Canouil M, Lecoeur C, Verbanck M, Lobbens S, Khamis A, Marselli L, Marchetti P, Kerr-Conte J, Pattou F, Marre M, Roussel R, Balkau B, ... Froguel P, et al. The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward. International Journal of Obesity (2005). PMID 31388097 DOI: 10.1038/S41366-019-0428-7 | 0.608 | |||
| 2019 | Vaxillaire M, Froguel P, Bonnefond A. How Recent Advances in Genomics Improve Precision Diagnosis and Personalized Care of Maturity-Onset Diabetes of the Young. Current Diabetes Reports. 19: 79. PMID 31385057 DOI: 10.1007/S11892-019-1202-X | 0.593 | |||
| 2019 | Liu CT, Merino J, Rybin D, DiCorpo D, Benke KS, Bragg-Gresham JL, Canouil M, Corre T, Grallert H, Isaacs A, Kutalik Z, Lahti J, Marullo L, Marzi C, Rasmussen-Torvik LJ, ... ... Froguel P, et al. Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals. Scientific Reports. 9: 9439. PMID 31263163 DOI: 10.1038/S41598-019-45823-7 | 0.364 | |||
| 2019 | Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, ... ... Froguel P, et al. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. PMID 31203377 DOI: 10.1007/S00125-019-4906-1 | 0.348 | |||
| 2019 | Khamis A, Canouil M, Siddiq A, Crouch H, Falchi M, Bulow MV, Ehehalt F, Marselli L, Distler M, Richter D, Weitz J, Bokvist K, Xenarios I, Thorens B, Schulte AM, ... ... Froguel P, et al. Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes. Molecular Metabolism. PMID 30956117 DOI: 10.1016/J.Molmet.2019.03.004 | 0.621 | |||
| 2019 | Frade-Proud'Hon-Clerc S, Smol T, Frenois F, Sand O, Vaillant E, Dhennin V, Bonnefond A, Froguel P, Fumery M, Guillon-Dellac N, Gower-Rousseau C, Vasseur F. A Novel Rare Missense Variation of the Gene: Evidencesof Implication in Crohn's Disease. International Journal of Molecular Sciences. 20. PMID 30769939 DOI: 10.3390/Ijms20040835 | 0.541 | |||
| 2019 | Bonnefond A, Froguel P, Study LESIRG. 29-OR: High Prevalence of Pathogenic Mutations in Genes Causing Monogenic Diabetes among Patients with Common Type 2 Diabetes Diabetes. 68. DOI: 10.2337/Db19-29-Or | 0.616 | |||
| 2019 | Imam A, Winnebeck E, Buchholz N, Froguel P, Bonnefond A, Solimena M, Ivanova A, Bouvier M, Plouffe B, Charpentier G, Karamitri A, Jockers R, Roenneberg T, Vetter C. Functional circadian and sleep phenotyping of type 2 diabetes patients with melatonin receptor 2 mutations and controls: a pilot study Sleep Medicine. 64: S166-S167. DOI: 10.1016/j.sleep.2019.11.460 | 0.525 | |||
| 2018 | Parmar P, Lowry E, Cugliari G, Suderman M, Wilson R, Karhunen V, Andrew T, Wiklund P, Wielscher M, Guarrera S, Teumer A, Lehne B, Milani L, de Klein N, Mishra PP, ... ... Froguel P, et al. Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults. Ebiomedicine. PMID 30442561 DOI: 10.1016/J.Ebiom.2018.10.066 | 0.506 | |||
| 2018 | Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, ... ... Froguel P, et al. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American Journal of Human Genetics. 103: 691-706. PMID 30388399 DOI: 10.1016/J.Ajhg.2018.09.009 | 0.316 | |||
| 2018 | Imatoh T, Yengo L, Rocheleau G, Kamimura S, Maeda S, Miyazaki M, Froguel P. ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers. Lipids. PMID 30334266 DOI: 10.1002/Lipd.12087 | 0.306 | |||
| 2018 | Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, Cook JP, Schmidt EM, Wuttke M, Sarnowski C, Mägi R, ... ... Froguel P, et al. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics. PMID 30297969 DOI: 10.1038/S41588-018-0241-6 | 0.375 | |||
| 2018 | Cousminer DL, Ahlqvist E, Mishra R, Andersen MK, Chesi A, Hawa MI, Davis A, Hodge KM, Bradfield JP, Zhou K, Guy VC, Åkerlund M, Wod M, Fritsche LG, Vestergaard H, ... ... Froguel P, et al. First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes. Diabetes Care. PMID 30254083 DOI: 10.2337/Dc18-1032 | 0.388 | |||
| 2018 | Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume JL, Hegron A, Boissel M, Canouil M, Langenberg C, Wareham NJ, Le Gouill C, Lukasheva V, Lichtarge O, Froguel P, et al. Type 2 diabetes-associated variants of the MT melatonin receptor affect distinct modes of signaling. Science Signaling. 11. PMID 30154102 DOI: 10.1126/Scisignal.Aan6622 | 0.586 | |||
| 2018 | Montagne L, Derhourhi M, Piton A, Toussaint B, Durand E, Vaillant E, Thuillier D, Gaget S, De Graeve F, Rabearivelo I, Lansiaux A, Lenne B, Sukno S, Desailloud R, Cnop M, ... ... Froguel P, et al. CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability. Molecular Metabolism. PMID 29784605 DOI: 10.1016/J.Molmet.2018.05.005 | 0.578 | |||
| 2018 | Abderrahmani A, Yengo L, Caiazzo R, Canouil M, Cauchi S, Raverdy V, Plaisance V, Pawlowski V, Lobbens S, Maillet J, Rolland L, Boutry R, Queniat G, Kwapich M, Tenenbaum M, ... ... Froguel P, et al. Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes. Diabetes. PMID 29728363 DOI: 10.2337/Db17-1539 | 0.732 | |||
| 2018 | Campanella G, Gunter MJ, Polidoro S, Krogh V, Palli D, Panico S, Sacerdote C, Tumino R, Fiorito G, Guarrera S, Iacoviello L, Bergdahl IA, Melin B, Lenner P, de Kok TMCM, ... ... Froguel P, et al. Epigenome-wide association study of adiposity and future risk of obesity-related diseases. International Journal of Obesity (2005). PMID 29713043 DOI: 10.1038/S41366-018-0064-7 | 0.327 | |||
| 2018 | Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, Guo X, Lu Y, Li M, Jensen RA, Hu Y, ... ... Froguel P, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics. 50: 559-571. PMID 29632382 DOI: 10.1038/S41588-018-0084-1 | 0.34 | |||
| 2018 | Griscelli F, Ezanno H, Soubeyrand M, Feraud O, Oudrhiri N, Bonnefond A, Turhan AG, Froguel P, Bennaceur-Griscelli A. Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation. Stem Cell Research. 29: 56-59. PMID 29597128 DOI: 10.1016/J.Scr.2018.02.017 | 0.604 | |||
| 2018 | Saeed S, Arslan M, Froguel P. Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes. Obesity (Silver Spring, Md.). 26: 474-484. PMID 29464904 DOI: 10.1002/Oby.22064 | 0.378 | |||
| 2018 | Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, ... ... Froguel P, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics. PMID 29455858 DOI: 10.1016/J.Ajhg.2018.01.015 | 0.312 | |||
| 2018 | Saeed S, Bonnefond A, Tamanini F, Mirza MU, Manzoor J, Janjua QM, Din SM, Gaitan J, Milochau A, Durand E, Vaillant E, Haseeb A, De Graeve F, Rabearivelo I, Sand O, ... ... Froguel P, et al. Loss-of-function mutations in ADCY3 cause monogenic severe obesity. Nature Genetics. PMID 29311637 DOI: 10.1038/S41588-017-0023-6 | 0.746 | |||
| 2018 | Tenenbaum M, Bonnefond A, Froguel P, Abderrahmani A. Physiopathologie du diabète Revue Francophone Des Laboratoires. 2018: 26-32. DOI: 10.1016/S1773-035X(18)30145-X | 0.73 | |||
| 2017 | Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, ... ... Froguel P, et al. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data. 4: 170179. PMID 29257133 DOI: 10.1038/Sdata.2017.179 | 0.354 | |||
| 2017 | Rabhi N, Hannou SA, Gromada X, Salas E, Yao X, Oger F, Carney C, Lopez-Mejia IC, Durand E, Rabearivelo I, Bonnefond A, Caron E, Fajas L, Dani C, Froguel P, et al. Cdkn2a deficiency promotes adipose tissue browning. Molecular Metabolism. PMID 29237539 DOI: 10.1016/J.Molmet.2017.11.012 | 0.62 | |||
| 2017 | Foucan L, Larifla L, Durand E, Rambhojan C, Armand C, Michel CT, Billy R, Dhennin V, De Graeve F, Rabearivelo I, Sand O, Lacorte JM, Froguel P, Bonnefond A. High Prevalence of Rare Monogenic Forms of Obesity in Obese Guadeloupean Afro-Caribbean Children. The Journal of Clinical Endocrinology and Metabolism. PMID 29216354 DOI: 10.1210/Jc.2017-01956 | 0.576 | |||
| 2017 | Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, ... ... Froguel P, et al. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia. PMID 29185012 DOI: 10.1007/S00125-017-4500-3 | 0.377 | |||
| 2017 | Bonnefond A, Froguel P. Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? Current Diabetes Reports. 17: 122. PMID 29063374 DOI: 10.1007/S11892-017-0957-1 | 0.63 | |||
| 2017 | Hancili S, Bonnefond A, Philippe J, Vaillant E, De Graeve F, Sand O, Busiah K, Robert JJ, Polak M, Froguel P, Güven A, Vaxillaire M. A novel NEUROG3 mutation in neonatal diabetes associated with a neuro-intestinal syndrome. Pediatric Diabetes. PMID 28940958 DOI: 10.1111/Pedi.12576 | 0.775 | |||
| 2017 | Griscelli F, Feraud O, Ernault T, Oudrihri N, Turhan AG, Bonnefond A, Froguel P, Bennaceur-Griscelli A. Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation. Stem Cell Research. 23: 178-181. PMID 28925365 DOI: 10.1016/J.Scr.2017.07.023 | 0.591 | |||
| 2017 | Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, ... ... Froguel P, et al. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. Plos Medicine. 14: e1002383. PMID 28898252 DOI: 10.1371/Journal.Pmed.1002383 | 0.63 | |||
| 2017 | Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, ... ... Froguel P, et al. Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. Plos Genetics. 13: e1006972. PMID 28832619 DOI: 10.1371/Journal.Pgen.1006972 | 0.519 | |||
| 2017 | Balkau B, Roussel R, Wagner S, Tichet J, Froguel P, Fagherazzi G, Bonnet F. Transmission of Type 2 diabetes to sons and daughters: the D.E.S.I.R. cohort. Diabetic Medicine : a Journal of the British Diabetic Association. PMID 28792638 DOI: 10.1111/Dme.13446 | 0.333 | |||
| 2017 | Peddinti G, Cobb J, Yengo L, Froguel P, Kravić J, Balkau B, Tuomi T, Aittokallio T, Groop L. Early metabolic markers identify potential targets for the prevention of type 2 diabetes. Diabetologia. PMID 28597074 DOI: 10.1007/S00125-017-4325-0 | 0.335 | |||
| 2017 | Ndiaye FK, Ortalli A, Canouil M, Huyvaert M, Salazar-Cardozo C, Lecoeur C, Verbanck M, Pawlowski V, Boutry R, Durand E, Rabearivelo I, Sand O, Marselli L, Kerr-Conte J, Chandra V, ... ... Froguel P, et al. Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion. Molecular Metabolism. 6: 459-470. PMID 28580277 DOI: 10.1016/J.Molmet.2017.03.011 | 0.762 | |||
| 2017 | Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, Jackson AU, Ferreira T, Lee Y, Ma C, Steinthorsdottir V, ... ... Froguel P, et al. An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes. PMID 28566273 DOI: 10.2337/Db16-1253 | 0.414 | |||
| 2017 | Juge PA, Borie R, Kannengiesser C, Gazal S, Revy P, Wemeau-Stervinou L, Debray MP, Ottaviani S, Marchand-Adam S, Nathan N, Thabut G, Richez C, Nunes H, Callebaut I, Justet A, ... ... Froguel P, et al. Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis. The European Respiratory Journal. 49. PMID 28495692 DOI: 10.1183/13993003.02314-2016 | 0.544 | |||
| 2017 | Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, ... ... Froguel P, et al. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. Plos Genetics. 13: e1006528. PMID 28448500 DOI: 10.1371/Journal.Pgen.1006528 | 0.582 | |||
| 2017 | Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, Ngwa JS, Ahluwalia TS, Chu AY, Heard-Costa NL, Lim E, ... ... Froguel P, et al. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications. 8: 14977. PMID 28443625 DOI: 10.1038/Ncomms14977 | 0.588 | |||
| 2017 | Antúnez-Ortiz DL, Flores-Alfaro E, Burguete-García AI, Bonnefond A, Peralta-Romero J, Froguel P, Espinoza-Rojo M, Cruz M. Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children. Biomed Research International. 2017: 2432957. PMID 28428959 DOI: 10.1155/2017/2432957 | 0.596 | |||
| 2017 | Saeed S, Bonnefond A, Manzoor J, Shabbir F, Ayesha H, Philippe J, Durand E, Crouch H, Sand O, Ali M, Butt T, Rathore AW, Falchi M, Arslan M, Froguel P. Erratum: Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population. Obesity (Silver Spring, Md.). 25: 807. PMID 28349664 DOI: 10.1002/oby.21803 | 0.737 | |||
| 2017 | Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, ... ... Froguel P, et al. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. PMID 28341696 DOI: 10.2337/Db16-1329 | 0.423 | |||
| 2017 | Bonnefond A, Froguel P. The case for too little melatonin signalling in increased diabetes risk. Diabetologia. PMID 28314944 DOI: 10.1007/S00125-017-4255-X | 0.612 | |||
| 2017 | Bonnefond A, Yengo L, Dechaume A, Canouil M, Castelain M, Roger E, Allegaert F, Caiazzo R, Raverdy V, Pigeyre M, Arredouani A, Borys JM, Lévy-Marchal C, Weill J, Roussel R, ... ... Froguel P, et al. Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach. Bmc Medicine. 15: 37. PMID 28228143 DOI: 10.1186/S12916-017-0784-X | 0.553 | |||
| 2017 | Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, ... ... Froguel P, et al. Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. American Journal of Human Genetics. PMID 28132686 DOI: 10.1016/J.Ajhg.2017.01.011 | 0.373 | |||
| 2017 | Tenenbaum M, Ezanno H, Plaisance V, Bricambert J, Boutry R, Beeler N, Bonnefond A, Kerr-Conte J, Pattou F, Froguel P, Abderrahmani A. C-Jun amino terminal kinase 3 (JNK3) contrôle la masse fonctionnelle de la cellule bêta en réponse à l’obésité Diabetes & Metabolism. 43. DOI: 10.1016/S1262-3636(17)30221-5 | 0.675 | |||
| 2017 | Vaxillaire M, Lecoeur C, Durand E, Vaillant E, Toussaint B, Leloire A, Graeve FD, Rabearivelo I, Sand O, Bonnefond A, Froguel P. Mutations exomiques rares transmises au sein de familles de type MODY : analyse de corrélation avec la variabilité phénotypique et les défauts métaboliques précoces Diabetes & Metabolism. 43. DOI: 10.1016/S1262-3636(17)30152-0 | 0.547 | |||
| 2017 | Ndiaye Fk, Ortalli A, Huyvaert M, Salazar-Cardozo C, Canouil M, Kerr-Conte J, Pattou F, Marselli L, Marchetti P, Scharfmann R, Froguel P, Bonnefond A. Identification de 4 nouveaux gènes à risque de diabète de type 2 modulant la fonction β pancréatique et l’insulino-sécrétion Diabetes & Metabolism. 43. DOI: 10.1016/S1262-3636(17)30151-9 | 0.523 | |||
| 2017 | Juge PA, Borie R, Kannengiesser C, Gazal S, Revy P, Wemeau-Stervinou L, Debray MP, Ottaviani S, Marchand-Adam S, Nathan N, Thabut G, Richez C, Nunes H, Callebaut I, Justet A, ... ... Froguel P, et al. Fond génétique partagé entre la pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde et la fibrose pulmonaire idiopathique Revue Des Maladies Respiratoires. 34. DOI: 10.1016/J.Rmr.2016.10.133 | 0.545 | |||
| 2016 | Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, ... ... Froguel P, et al. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The Lancet. Diabetes & Endocrinology. PMID 27908689 DOI: 10.1016/S2213-8587(16)30396-5 | 0.606 | |||
| 2016 | Bricambert J, Favre D, Brajkovic S, Bonnefond A, Boutry R, Salvi R, Plaisance V, Chikri M, Chinetti-Gbaguidi G, Staels B, Giusti V, Caiazzo R, Pattou F, Waeber G, Froguel P, et al. Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. Molecular Metabolism. 5: 1200-1207. PMID 27900262 DOI: 10.1016/J.Molmet.2016.09.011 | 0.717 | |||
| 2016 | Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A, ... ... Froguel P, et al. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics. PMID 27798627 DOI: 10.1038/Ng.3698 | 0.35 | |||
| 2016 | Yengo L, Arredouani A, Marre M, Roussel R, Vaxillaire M, Falchi M, Haoudi A, Tichet J, Balkau B, Bonnefond A, Froguel P. Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. Molecular Metabolism. 5: 918-25. PMID 27689004 DOI: 10.1016/J.Molmet.2016.08.011 | 0.578 | |||
| 2016 | Plaisance V, Brajkovic S, Tenenbaum M, Favre D, Ezanno H, Bonnefond A, Bonner C, Gmyr V, Kerr-Conte J, Gauthier BR, Widmann C, Waeber G, Pattou F, Froguel P, Abderrahmani A. Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL. Plos One. 11: e0163046. PMID 27636901 DOI: 10.1371/Journal.Pone.0163046 | 0.686 | |||
| 2016 | Bonnefond A, Karamitri A, Jockers R, Froguel P. The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm. Cell Metabolism. 24: 345-7. PMID 27626190 DOI: 10.1016/J.Cmet.2016.08.015 | 0.583 | |||
| 2016 | Morandi A, Bonnefond A, Lobbens S, Yengo L, Miraglia Del Giudice E, Grandone A, Lévy-Marchal C, Weill J, Maffeis C, Froguel P. Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youths. The Journal of Clinical Endocrinology and Metabolism. jc20162432. PMID 27588439 DOI: 10.1210/Jc.2016-2432 | 0.647 | |||
| 2016 | Vaxillaire M, Bonnefond A, Froguel P. Comment on Beltrand et al. Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations. Diabetes Care 2015;38:2033-2041. Diabetes Care. 39: e153-4. PMID 27555630 DOI: 10.2337/Dc15-2703 | 0.576 | |||
| 2016 | Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, ... ... Froguel P, et al. The genetic architecture of type 2 diabetes. Nature. PMID 27398621 DOI: 10.1038/Nature18642 | 0.403 | |||
| 2016 | Vaxillaire M, Froguel P. Monogenic diabetes: Implementation of translational genomic research towards precision medicine. Journal of Diabetes. 8: 782-795. PMID 27390143 DOI: 10.1111/1753-0407.12446 | 0.396 | |||
| 2016 | Vergoni B, Cornejo PJ, Gilleron J, Dedjani M, Ceppo F, Jacquel A, Bouget G, Ginet C, Gonzalez T, Maillet J, Dhennin V, Verbanck M, Auberger P, Froguel P, Tanti JF, et al. DNA damage and the activation of the p53 pathway mediate alterations in metabolic and secretory functions of adipocytes. Diabetes. PMID 27388216 DOI: 10.2337/Db16-0014 | 0.317 | |||
| 2016 | Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, ... ... Froguel P, et al. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Plos Genetics. 12: e1006166. PMID 27355579 DOI: 10.1371/Journal.Pgen.1006166 | 0.475 | |||
| 2016 | Favennec M, Hennart B, Verbanck M, Pigeyre M, Caiazzo R, Raverdy V, Verkindt H, Leloire A, Guillemin GJ, Yengo L, Allorge D, Froguel P, Pattou F, Poulain-Godefroy O. Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis. Plos One. 11: e0158051. PMID 27327770 DOI: 10.1371/Journal.Pone.0158051 | 0.328 | |||
| 2016 | Bonnefond A, Keller R, Meyre D, Stutzmann F, Thuillier D, Stefanov DG, Froguel P, Horber FF, Kral JG. Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A Six-Year Prospective Study. Diabetes Care. PMID 27222505 DOI: 10.2337/Dc16-0115 | 0.775 | |||
| 2016 | Lamri A, Bonnefond A, Meyre D, Balkau B, Roussel R, Marre M, Froguel P, Fumeron F. Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study Nutrition Metabolism and Cardiovascular Diseases. 26: 931-936. PMID 27212621 DOI: 10.1016/J.Numecd.2016.04.010 | 0.586 | |||
| 2016 | Rabhi N, Denechaud PD, Gromada X, Hannou SA, Zhang H, Rashid T, Salas E, Durand E, Sand O, Bonnefond A, Yengo L, Chavey C, Bonner C, Kerr-Conte J, Abderrahmani A, ... ... Froguel P, et al. KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Reports. PMID 27117420 DOI: 10.1016/J.Celrep.2016.03.079 | 0.724 | |||
| 2016 | Horikoshi M, Pasquali L, Wiltshire S, Huyghe JR, Mahajan A, Asimit JL, Ferreira T, Locke AE, Robertson NR, Wang X, Sim X, Fujita H, Hara K, Young R, Zhang W, ... ... Froguel P, et al. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics. PMID 26911676 DOI: 10.1093/Hmg/Ddw048 | 0.376 | |||
| 2016 | Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T, Evans DM, Falchi M, Feitosa MF, Ferreira T, Hedman ÅK, ... ... Froguel P, et al. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications. 7: 10495. PMID 26833246 DOI: 10.1038/Ncomms10495 | 0.594 | |||
| 2016 | Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, ... ... Froguel P, et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications. 7: 10023. PMID 26831199 DOI: 10.1038/Ncomms10023 | 0.331 | |||
| 2016 | Ndiaye F, Ortalli A, Verbanck M, Huyvaert M, Salazar-Cardozo C, Yengo L, Marselli L, Marchetti P, Froguel P, Bonnefond A. CO-68: L'étude génomique et fonctionnelle des gènes du diabète de type 2 confirme leur rôle dans les cellules beta-pancréatiques Diabetes & Metabolism. 42. DOI: 10.1016/S1262-3636(16)30086-6 | 0.559 | |||
| 2016 | Cauchi S, Yengo L, Canouïl M, Régent AS, Benoit P, Lobbens S, Maillet J, Lassailly G, Caïazzo R, Raverdy V, Abderrahmani A, Ling C, Hampe J, Pattou F, Froguel P. CO-16: Nouveaux marqueurs épigénétiques spécifiques du foie chez les obèses diabétiques de type 2 Diabetes & Metabolism. 42. DOI: 10.1016/S1262-3636(16)30034-9 | 0.613 | |||
| 2016 | Juge PA, Borie R, Kannengiesser C, Gazal S, Revy P, Wemeau-Stervinou L, Debray MP, Ottaviani S, Marchand-Adam S, Nathan N, Thabut G, Richez C, Nunes H, Callebaut I, Justet A, ... ... Froguel P, et al. Fond génétique partagé entre la pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde et la fibrose pulmonaire idiopathique Revue Du Rhumatisme. 83. DOI: 10.1016/S1169-8330(16)30345-3 | 0.51 | |||
| 2015 | Felix JF, Bradfield JP, Monnereau C, van der Valk RJ, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Møller E, Mahajan A, Pitkänen N, Joro R, Cavadino A, Huikari V, ... ... Froguel P, et al. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics. PMID 26604143 DOI: 10.1093/Hmg/Ddv472 | 0.573 | |||
| 2015 | Philippe J, Derhourhi M, Durand E, Vaillant E, Dechaume A, Rabearivelo I, Dhennin V, Vaxillaire M, De Graeve F, Sand O, Froguel P, Bonnefond A. What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity? Plos One. 10: e0143373. PMID 26599467 DOI: 10.1371/Journal.Pone.0143373 | 0.762 | |||
| 2015 | Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, ... ... Froguel P, et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics. PMID 26551672 DOI: 10.1038/Ng.3437 | 0.385 | |||
| 2015 | Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, ... ... Froguel P, et al. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Plos Genetics. 11: e1005378. PMID 26426971 DOI: 10.1371/Journal.Pgen.1005378 | 0.546 | |||
| 2015 | Favennec M, Hennart B, Caiazzo R, Leloire A, Yengo L, Verbanck M, Arredouani A, Marre M, Pigeyre M, Bessede A, Guillemin GJ, Chinetti G, Staels B, Pattou F, Balkau B, ... ... Froguel P, et al. The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. Obesity (Silver Spring, Md.). 23: 2066-74. PMID 26347385 DOI: 10.1002/Oby.21199 | 0.324 | |||
| 2015 | Saeed S, Bonnefond A, Manzoor J, Shabir F, Ayesha H, Philippe J, Durand E, Crouch H, Sand O, Ali M, Butt T, Rathore AW, Falchi M, Arslan M, Froguel P. Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population. Obesity (Silver Spring, Md.). 23: 1687-95. PMID 26179253 DOI: 10.1002/Oby.21142 | 0.769 | |||
| 2015 | Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stančáková A, Faul JD, Zhao W, Bartz TM, ... ... Froguel P, et al. Directional dominance on stature and cognition in diverse human populations. Nature. 523: 459-62. PMID 26131930 DOI: 10.1038/Nature14618 | 0.552 | |||
| 2015 | Morandi A, Bonnefond A, Lobbens S, Carotenuto M, Del Giudice EM, Froguel P, Maffeis C. A girl with incomplete Prader-Willi syndrome and negative MS-PCR, found to have mosaic maternal UPD-15 at SNP array. American Journal of Medical Genetics. Part A. 167: 2720-6. PMID 26109092 DOI: 10.1002/Ajmg.A.37222 | 0.543 | |||
| 2015 | Chambers JC, Loh M, Lehne B, Drong A, Kriebel J, Motta V, Wahl S, Elliott HR, Rota F, Scott WR, Zhang W, Tan ST, Campanella G, Chadeau-Hyam M, Yengo L, ... ... Froguel P, et al. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study. The Lancet. Diabetes & Endocrinology. PMID 26095709 DOI: 10.1016/S2213-8587(15)00127-8 | 0.361 | |||
| 2015 | Bonnefond A, Yengo L, Le May C, Fumeron F, Marre M, Balkau B, Charpentier G, Franc S, Froguel P, Cariou B. The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis. Diabetologia. PMID 26049403 DOI: 10.1007/S00125-015-3659-8 | 0.609 | |||
| 2015 | Bonnefond A, Lamri A, Leloire A, Vaillant E, Roussel R, Lévy-Marchal C, Weill J, Galan P, Hercberg S, Ragot S, Hadjadj S, Charpentier G, Balkau B, Marre M, Fumeron F, ... Froguel P, et al. Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels. Journal of Medical Genetics. 52: 595-8. PMID 26025001 DOI: 10.1136/Jmedgenet-2015-103065 | 0.612 | |||
| 2015 | Al-Sinani S, Woodhouse N, Al-Mamari A, Al-Shafie O, Al-Shafaee M, Al-Yahyaee S, Hassan M, Jaju D, Al-Hashmi K, Al-Abri M, Al-Rassadi K, Rizvi S, Loic Y, Froguel P, Bayoumi R. Association of gene variants with susceptibility to type 2 diabetes among Omanis. World Journal of Diabetes. 6: 358-66. PMID 25789119 DOI: 10.4239/Wjd.V6.I2.358 | 0.417 | |||
| 2015 | Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, ... ... Froguel P, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 518: 197-206. PMID 25673413 DOI: 10.1038/Nature14177 | 0.393 | |||
| 2015 | Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, ... ... Froguel P, et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 518: 187-96. PMID 25673412 DOI: 10.1038/Nature14132 | 0.356 | |||
| 2015 | Stathopoulou MG, Petrelis AM, Buxton JL, Froguel P, Blakemore AI, Visvikis-Siest S. Genetic determinants of leucocyte telomere length in children: a neglected and challenging field. Paediatric and Perinatal Epidemiology. 29: 146-50. PMID 25641522 DOI: 10.1111/Ppe.12173 | 0.308 | |||
| 2015 | Bonnefond A, Froguel P. Rare and common genetic events in type 2 diabetes: what should biologists know? Cell Metabolism. 21: 357-68. PMID 25640731 DOI: 10.1016/J.Cmet.2014.12.020 | 0.614 | |||
| 2015 | Mejía-Benítez MA, Bonnefond A, Yengo L, Huyvaert M, Dechaume A, Peralta-Romero J, Klünder-Klünder M, García Mena J, El-Sayed Moustafa JS, Falchi M, Cruz M, Froguel P. Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia. 58: 290-4. PMID 25394825 DOI: 10.1007/S00125-014-3441-3 | 0.612 | |||
| 2015 | Philippe J, Stijnen P, Meyre D, De Graeve F, Thuillier D, Delplanque J, Gyapay G, Sand O, Creemers JW, Froguel P, Bonnefond A. A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity. International Journal of Obesity (2005). 39: 295-302. PMID 24890885 DOI: 10.1038/Ijo.2014.96 | 0.799 | |||
| 2015 | Neve B, Ortalli A, Leloire A, Feraud O, Pasquetti G, Vaxillaire M, Bonnefond A, Bennaceur-Griscelli A, Kerr-Conte J, Froguel P. P202 Utilisation des cellules souches somatiques pour modéliser le diabète monogénique lié aux anomalies du canal potassique de KCNJ11 Diabetes & Metabolism. 41. DOI: 10.1016/S1262-3636(15)30315-3 | 0.568 | |||
| 2015 | Bonnefond A, Yengo L, Balkau B, Marre M, Brousseau T, Froguel P. O52 L’activité enzymatique plasmatique de l’amylase pancréatique est associée à une diminution de l’indice de masse corporelle et protège du risque de diabète dans la cohorte D.E.S.I.R. Diabetes & Metabolism. 41. DOI: 10.1016/S1262-3636(15)30052-5 | 0.539 | |||
| 2014 | Chandra V, Albagli-Curiel O, Hastoy B, Piccand J, Randriamampita C, Vaillant E, Cavé H, Busiah K, Froguel P, Vaxillaire M, Rorsman P, Polak M, Scharfmann R. RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells. Cell Reports. 9: 2206-18. PMID 25497100 DOI: 10.1016/J.Celrep.2014.11.010 | 0.356 | |||
| 2014 | Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, ... ... Froguel P, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46: 1173-86. PMID 25282103 DOI: 10.1038/Ng.3097 | 0.337 | |||
| 2014 | Montagne L, Raimondo A, Delobel B, Duban-Bedu B, Noblet FS, Dechaume A, Bersten DC, Meyre D, Whitelaw ML, Froguel P, Bonnefond A. Identification of two novel loss-of-function SIM1 mutations in two overweight children with developmental delay. Obesity (Silver Spring, Md.). 22: 2621-4. PMID 25234154 DOI: 10.1002/Oby.20886 | 0.58 | |||
| 2014 | Rouskas K, Cauchi S, Raverdy V, Yengo L, Froguel P, Pattou F. Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients. Surgery For Obesity and Related Diseases : Official Journal of the American Society For Bariatric Surgery. 10: 679-83. PMID 25224167 DOI: 10.1016/J.Soard.2013.12.016 | 0.393 | |||
| 2014 | Perimenis P, Bouckenooghe T, Delplanque J, Moitrot E, Eury E, Lobbens S, Gosset P, Devisme L, Duvillie B, Abderrahmani A, Storme L, Fontaine P, Froguel P, Vambergue A. Placental antiangiogenic prolactin fragments are increased in human and rat maternal diabetes. Biochimica Et Biophysica Acta. 1842: 1783-93. PMID 24984282 DOI: 10.1016/J.Bbadis.2014.06.026 | 0.784 | |||
| 2014 | Vaxillaire M, Yengo L, Lobbens S, Rocheleau G, Eury E, Lantieri O, Marre M, Balkau B, Bonnefond A, Froguel P. Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study. Diabetologia. 57: 1601-10. PMID 24893864 DOI: 10.1007/S00125-014-3277-X | 0.626 | |||
| 2014 | Langenberg C, Sharp SJ, Franks PW, Scott RA, Deloukas P, Forouhi NG, Froguel P, Groop LC, Hansen T, Palla L, Pedersen O, Schulze MB, Tormo MJ, Wheeler E, Agnoli C, et al. Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study. Plos Medicine. 11: e1001647. PMID 24845081 DOI: 10.1371/Journal.Pmed.1001647 | 0.432 | |||
| 2014 | Sullivan AE, Raimondo A, Schwab TA, Bruning JB, Froguel P, Farooqi IS, Peet DJ, Whitelaw ML. Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. The Biochemical Journal. 461: 403-12. PMID 24814368 DOI: 10.1042/Bj20131618 | 0.343 | |||
| 2014 | Rabhi N, Salas E, Froguel P, Annicotte JS. Role of the unfolded protein response in β cell compensation and failure during diabetes. Journal of Diabetes Research. 2014: 795171. PMID 24812634 DOI: 10.1155/2014/795171 | 0.313 | |||
| 2014 | Makki K, Taront S, Molendi-Coste O, Bouchaert E, Neve B, Eury E, Lobbens S, Labalette M, Duez H, Staels B, Dombrowicz D, Froguel P, Wolowczuk I. Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice. Plos One. 9: e92684. PMID 24710396 DOI: 10.1371/Journal.Pone.0092684 | 0.332 | |||
| 2014 | Prokopenko I, Poon W, Mägi R, Prasad B R, Salehi SA, Almgren P, Osmark P, Bouatia-Naji N, Wierup N, Fall T, StanÄáková A, Barker A, Lagou V, Osmond C, Xie W, ... ... Froguel P, et al. A central role for GRB10 in regulation of islet function in man. Plos Genetics. 10: e1004235. PMID 24699409 DOI: 10.1371/Journal.Pgen.1004235 | 0.359 | |||
| 2014 | Falchi M, El-Sayed Moustafa JS, Takousis P, Pesce F, Bonnefond A, Andersson-Assarsson JC, Sudmant PH, Dorajoo R, Al-Shafai MN, Bottolo L, Ozdemir E, So HC, Davies RW, Patrice A, Dent R, ... ... Froguel P, et al. Low copy number of the salivary amylase gene predisposes to obesity. Nature Genetics. 46: 492-7. PMID 24686848 DOI: 10.1038/Ng.2939 | 0.619 | |||
| 2014 | Svensson PA, Wahlstrand B, Olsson M, Froguel P, Falchi M, Bergman RN, McTernan PG, Hedner T, Carlsson LM, Jacobson P. CDKN2B expression and subcutaneous adipose tissue expandability: possible influence of the 9p21 atherosclerosis locus. Biochemical and Biophysical Research Communications. 446: 1126-31. PMID 24680834 DOI: 10.1016/J.Bbrc.2014.03.075 | 0.344 | |||
| 2014 | Abdelalim EM, Bonnefond A, Bennaceur-Griscelli A, Froguel P. Pluripotent stem cells as a potential tool for disease modelling and cell therapy in diabetes. Stem Cell Reviews. 10: 327-37. PMID 24577791 DOI: 10.1007/S12015-014-9503-6 | 0.587 | |||
| 2014 | Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, ... ... Froguel P, et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics. 46: 234-44. PMID 24509480 DOI: 10.1038/Ng.2897 | 0.396 | |||
| 2014 | Neve B, Le Bacquer O, Caron S, Huyvaert M, Leloire A, Poulain-Godefroy O, Lecoeur C, Pattou F, Staels B, Froguel P. Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level. Diabetologia. 57: 785-96. PMID 24463962 DOI: 10.1007/S00125-013-3154-Z | 0.345 | |||
| 2014 | Saeed S, Bonnefond A, Manzoor J, Philippe J, Durand E, Arshad M, Sand O, Butt TA, Falchi M, Arslan M, Froguel P. Novel LEPR mutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing. Obesity (Silver Spring, Md.). 22: 1112-7. PMID 24319006 DOI: 10.1002/Oby.20667 | 0.756 | |||
| 2014 | Dimas AS, Lagou V, Barker A, Knowles JW, Mägi R, Hivert MF, Benazzo A, Rybin D, Jackson AU, Stringham HM, Song C, Fischer-Rosinsky A, Boesgaard TW, Grarup N, Abbasi FA, ... ... Froguel P, et al. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes. 63: 2158-71. PMID 24296717 DOI: 10.2337/Db13-0949 | 0.398 | |||
| 2014 | Oger F, Dubois-Chevalier J, Gheeraert C, Avner S, Durand E, Froguel P, Salbert G, Staels B, Lefebvre P, Eeckhoute J. Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes. The Journal of Biological Chemistry. 289: 708-22. PMID 24288131 DOI: 10.1074/Jbc.M113.526996 | 0.315 | |||
| 2014 | Bonnefond A, Philippe J, Durand E, Muller J, Saeed S, Arslan M, MartÃnez R, De Graeve F, Dhennin V, Rabearivelo I, Polak M, Cavé H, Castaño L, Vaxillaire M, Mandel JL, ... ... Froguel P, et al. Highly sensitive diagnosis of 43 monogenic forms of diabetes or obesity through one-step PCR-based enrichment in combination with next-generation sequencing. Diabetes Care. 37: 460-7. PMID 24041679 DOI: 10.2337/Dc13-0698 | 0.774 | |||
| 2014 | Saeed S, Bech PR, Hafeez T, Alam R, Falchi M, Ghatei MA, Bloom SR, Arslan M, Froguel P. Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects. Endocrine. 45: 401-8. PMID 23824601 DOI: 10.1007/S12020-013-0009-9 | 0.338 | |||
| 2014 | Moustafa JSE, Froguel P. Correction: From obesity genetics to the future of personalized obesity therapy Nature Reviews Endocrinology. 10: 4-4. DOI: 10.1038/Nrendo.2013.220 | 0.326 | |||
| 2014 | Abderrahmani A, Salvi R, Raphael B, Annicotte J, Froguel P. P193 Le répresseur transcriptionel ICER est essentiel au contrôle de l’homéostasie glucidique et du rythme circadien dans les îlots pancréatiques Diabetes & Metabolism. 40. DOI: 10.1016/S1262-3636(14)72484-X | 0.606 | |||
| 2014 | Bonnefond A, Saeed S, Manzoor J, Philippe J, Durand E, Sand O, Butt T, Falchi M, Arslan M, Froguel P. PO13 Identification par séquençage de nouvelle génération de deux nouvelles mutations situées dans LEPR, chez des enfants pakistanais avec une obésité sévère et issus de familles consanguines Diabetes & Metabolism. 40. DOI: 10.1016/S1262-3636(14)72271-2 | 0.738 | |||
| 2014 | Favennec M, Hennart B, Leloire A, Bessede A, Guillemin G, Kerr-Conte J, Allorge D, Pattou F, Froguel P, Poulain-Godefroy O. O47 Dérégulation de la voie des kynurénines dans le diabète de type 2 associé à l’obésité Diabetes & Metabolism. 40. DOI: 10.1016/S1262-3636(14)72221-9 | 0.304 | |||
| 2014 | Vaxillaire M, Yengo L, Lobbens S, Rocheleau G, Eury E, Lantieri O, Marre M, Balkau B, Bonnefond A, Froguel P. O31 Deux scores de risque génétique sont fortement associés aux variations de glycémie à jeun et à l’incidence d’hyperglycémie et de diabète de type 2 dans l’étude prospective D.E.S.I.R Diabetes & Metabolism. 40. DOI: 10.1016/S1262-3636(14)72205-0 | 0.56 | |||
| 2014 | Rabhi N, Denechaud P, Salas E, Bonnefond A, Bettignies CD, Froguel P, Annicotte J. O5 La lysine acetyl-transferase P300/CBP-associated factor (PCAF) contrôle la sécrétion d’insuline et la réponse au stress du reticulum Diabetes & Metabolism. 40. DOI: 10.1016/S1262-3636(14)72179-2 | 0.538 | |||
| 2014 | Perimenis P, Moitrot E, Gosset P, Eury E, Fontaine P, Froguel P, Vambergue A. Placental prolactin family levels are modified during gestation in the diabetic rat Placenta. 35. DOI: 10.1016/J.Placenta.2014.06.101 | 0.32 | |||
| 2013 | Busiah K, Drunat S, Vaivre-Douret L, Bonnefond A, Simon A, Flechtner I, Gérard B, Pouvreau N, Elie C, Nimri R, De Vries L, Tubiana-Rufi N, Metz C, Bertrand AM, Nivot-Adamiak S, ... ... Froguel P, et al. Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected]. The Lancet. Diabetes & Endocrinology. 1: 199-207. PMID 24622368 DOI: 10.1016/S2213-8587(13)70059-7 | 0.6 | |||
| 2013 | Makki K, Froguel P, Wolowczuk I. Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. Isrn Inflammation. 2013: 139239. PMID 24455420 DOI: 10.1155/2013/139239 | 0.315 | |||
| 2013 | Jääskeläinen A, Schwab U, Kolehmainen M, Kaakinen M, Savolainen MJ, Froguel P, Cauchi S, Järvelin MR, Laitinen J. Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986. Plos One. 8: e73802. PMID 24040077 DOI: 10.1371/Journal.Pone.0073802 | 0.364 | |||
| 2013 | Bottolo L, Chadeau-Hyam M, Hastie DI, Zeller T, Liquet B, Newcombe P, Yengo L, Wild PS, Schillert A, Ziegler A, Nielsen SF, Butterworth AS, Ho WK, Castagné R, Munzel T, ... ... Froguel P, et al. GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. Plos Genetics. 9: e1003657. PMID 23950726 DOI: 10.1371/Journal.Pgen.1003657 | 0.33 | |||
| 2013 | Bonnet F, Roussel R, Natali A, Cauchi S, Petrie J, Laville M, Yengo L, Froguel P, Lange C, Lantieri O, Marre M, Balkau B, Ferrannini E. Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts. Diabetologia. 56: 2414-23. PMID 23942764 DOI: 10.1007/S00125-013-3021-Y | 0.388 | |||
| 2013 | Bonnefond A, Froguel P. Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck. Genome Biology. 14: 309. PMID 23899211 DOI: 10.1186/Gb-2013-14-7-309 | 0.555 | |||
| 2013 | Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, ... ... Froguel P, et al. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nature Genetics. 45: 1044-9. PMID 23872634 DOI: 10.1038/Ng.2712 | 0.328 | |||
| 2013 | Bonnefond A, Skrobek B, Lobbens S, Eury E, Thuillier D, Cauchi S, Lantieri O, Balkau B, Riboli E, Marre M, Charpentier G, Yengo L, Froguel P. Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications. Nature Genetics. 45: 1040-3. PMID 23852171 DOI: 10.1038/Ng.2700 | 0.616 | |||
| 2013 | Dorajoo R, Li R, Ikram MK, Liu J, Froguel P, Lee J, Sim X, Ong RT, Tay WT, Peng C, Young TL, Blakemore AI, Cheng CY, Aung T, Mitchell P, et al. Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? Plos One. 8: e67650. PMID 23844046 DOI: 10.1371/Journal.Pone.0067650 | 0.316 | |||
| 2013 | Bonnefond A, Raimondo A, Stutzmann F, Ghoussaini M, Ramachandrappa S, Bersten DC, Durand E, Vatin V, Balkau B, Lantieri O, Raverdy V, Pattou F, Van Hul W, Van Gaal L, Peet DJ, ... ... Froguel P, et al. Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. The Journal of Clinical Investigation. 123: 3037-41. PMID 23778136 DOI: 10.1172/Jci68035 | 0.81 | |||
| 2013 | Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, ... ... Froguel P, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. Plos Genetics. 9: e1003500. PMID 23754948 DOI: 10.1371/Journal.Pgen.1003500 | 0.567 | |||
| 2013 | Robiou-du-Pont S, Yengo L, Vaillant E, Lobbens S, Durand E, Horber F, Lantieri O, Marre M, Balkau B, Froguel P, Meyre D. Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. Journal of Molecular Medicine (Berlin, Germany). 91: 1109-15. PMID 23640704 DOI: 10.1007/S00109-013-1027-Z | 0.389 | |||
| 2013 | Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, ... ... Froguel P, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics. 45: 501-12. PMID 23563607 DOI: 10.1038/Ng.2606 | 0.371 | |||
| 2013 | Bonnefond A, Vaillant E, Philippe J, Skrobek B, Lobbens S, Yengo L, Huyvaert M, Cavé H, Busiah K, Scharfmann R, Polak M, Abdul-Rasoul M, Froguel P, Vaxillaire M. Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family. Diabetes & Metabolism. 39: 276-80. PMID 23562494 DOI: 10.1016/J.Diabet.2013.02.007 | 0.78 | |||
| 2013 | Walters RG, Coin LJ, Ruokonen A, de Smith AJ, El-Sayed Moustafa JS, Jacquemont S, Elliott P, Esko T, Hartikainen AL, Laitinen J, Männik K, Martinet D, Meyre D, Nauck M, Schurmann C, ... ... Froguel P, et al. Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. Plos One. 8: e58048. PMID 23554873 DOI: 10.1371/Journal.Pone.0058048 | 0.395 | |||
| 2013 | El-Sayed Moustafa JS, Froguel P. From obesity genetics to the future of personalized obesity therapy. Nature Reviews. Endocrinology. 9: 402-13. PMID 23529041 DOI: 10.1038/Nrendo.2013.57 | 0.375 | |||
| 2013 | Svensson PA, Olsson M, Andersson-Assarsson JC, Taube M, Pereira MJ, Froguel P, Jacobson P. The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate. Biochemical and Biophysical Research Communications. 433: 563-6. PMID 23523790 DOI: 10.1016/J.Bbrc.2013.03.031 | 0.311 | |||
| 2013 | Ahlin S, Sjöholm K, Jacobson P, Andersson-Assarsson JC, Walley A, Tordjman J, Poitou C, Prifti E, Jansson PA, Borén J, Sjöström L, Froguel P, Bergman RN, Carlsson LM, Olsson B, et al. Macrophage gene expression in adipose tissue is associated with insulin sensitivity and serum lipid levels independent of obesity. Obesity (Silver Spring, Md.). 21: E571-6. PMID 23512687 DOI: 10.1002/Oby.20443 | 0.346 | |||
| 2013 | Mardinoglu A, Agren R, Kampf C, Asplund A, Nookaew I, Jacobson P, Walley AJ, Froguel P, Carlsson LM, Uhlen M, Nielsen J. Integration of clinical data with a genome-scale metabolic model of the human adipocyte. Molecular Systems Biology. 9: 649. PMID 23511207 DOI: 10.1038/Msb.2013.5 | 0.335 | |||
| 2013 | Baerenwald DA, Bonnefond A, Bouatia-Naji N, Flemming BP, Umunakwe OC, Oeser JK, Pound LD, Conley NL, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O, Dadi PK, ... ... Froguel P, et al. Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels. Diabetologia. 56: 1306-16. PMID 23508304 DOI: 10.1007/S00125-013-2875-3 | 0.555 | |||
| 2013 | Bonnefond A, Saulnier PJ, Stathopoulou MG, Grarup N, Ndiaye NC, Roussel R, Nezhad MA, Dechaume A, Lantieri O, Hercberg S, Lauritzen T, Balkau B, El-Sayed Moustafa JS, Hansen T, Pedersen O, ... Froguel P, et al. What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications? Plos One. 8: e55921. PMID 23405237 DOI: 10.1371/Journal.Pone.0055921 | 0.597 | |||
| 2013 | MejÃa-BenÃtez A, Klünder-Klünder M, Yengo L, Meyre D, Aradillas C, Cruz E, Pérez-Luque E, Malacara JM, Garay ME, Peralta-Romero J, Flores-Huerta S, GarcÃa-Mena J, Froguel P, Cruz M, Bonnefond A. Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. Bmc Medical Genetics. 14: 21. PMID 23375129 DOI: 10.1186/1471-2350-14-21 | 0.611 | |||
| 2013 | Nookaew I, Svensson PA, Jacobson P, Jernås M, Taube M, Larsson I, Andersson-Assarsson JC, Sjöström L, Froguel P, Walley A, Nielsen J, Carlsson LM. Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men. The Journal of Clinical Endocrinology and Metabolism. 98: E370-8. PMID 23264395 DOI: 10.1210/Jc.2012-2764 | 0.309 | |||
| 2013 | Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, ... ... Froguel P, et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics. 45: 145-54. PMID 23263486 DOI: 10.1038/Ng.2500 | 0.322 | |||
| 2013 | Bonnefond A, Yengo L, Philippe J, Dechaume A, Ezzidi I, Vaillant E, Gjesing AP, Andersson EA, Czernichow S, Hercberg S, Hadjadj S, Charpentier G, Lantieri O, Balkau B, Marre M, ... ... Froguel P, et al. Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes. Diabetologia. 56: 492-6. PMID 23224494 DOI: 10.1007/S00125-012-2794-8 | 0.783 | |||
| 2013 | Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimäki T, Kreiner-Møller E, Warrington NM, ... ... Froguel P, et al. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics. 45: 76-82. PMID 23202124 DOI: 10.1038/Ng.2477 | 0.355 | |||
| 2013 | Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY, Korneliussen T, Li Q, Nie C, Wu R, Skotte L, Morris AP, Ladenvall C, ... ... Froguel P, et al. Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia. 56: 298-310. PMID 23160641 DOI: 10.1007/S00125-012-2756-1 | 0.385 | |||
| 2013 | Robiou-du-Pont S, Bonnefond A, Yengo L, Vaillant E, Lobbens S, Durand E, Weill J, Lantieri O, Balkau B, Charpentier G, Marre M, Froguel P, Meyre D. Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population International Journal of Obesity. 37: 980-985. PMID 23090577 DOI: 10.1038/Ijo.2012.175 | 0.641 | |||
| 2013 | Froguel P, Bonnefond A. Does Type 2 diabetes increase the risk of developing cancer Diabetes Management. 3: 439-441. DOI: 10.2217/Dmt.13.49 | 0.554 | |||
| 2013 | Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Chonka DCC, Day FR, Fall T, ... ... Froguel P, et al. Supplementary material 1 Tel Aviv: Journal of the Institute of Archaeology of Tel Aviv University. DOI: 10.1179/10.1179/1077352513Z.00000000072.S1 | 0.404 | |||
| 2013 | Cauchi S, Yengo L, Eury E, Leloire A, Poulain O, Pattou F, Froguel P. P2084 Méthylation de l’ADN dans le foie et diabète de type 2 : une étude pilote Diabetes & Metabolism. 39. DOI: 10.1016/S1262-3636(13)71994-3 | 0.307 | |||
| 2013 | Abderrahmani A, Beeler N, Marenzoni R, Bouckenooghe T, Sisino G, Froguel P, Gargani S, Waeber G, Fontaine P, Keer-Conte J, Vambergue A, Pattou F. PO9 Rôle de la signalisation de JNK dans l’adaptation des cellules béta-pancréatiques au cours de la grossesse et de l’obésité Diabetes & Metabolism. 39. DOI: 10.1016/S1262-3636(13)71705-1 | 0.604 | |||
| 2013 | Bonnefond A, Skrobek B, Lobbens S, Eury E, Balkau B, Riboli E, Marre M, Charpentier G, Yengo L, Froguel P. O61 Le diabète de type 2 est responsable d’anomalies chromosomiques somatiques en mosaïques qui sont pré-cancéreuses Diabetes & Metabolism. 39. DOI: 10.1016/S1262-3636(13)71673-2 | 0.55 | |||
| 2013 | Annicotte J-, Denechaud P-, Rabhi N, Bonnefond A, Bettignies CD, Froguel P. O50 La protéine P300/CBP-associated factor (PCAF) est une histone acetyl-transferase qui contrôle la fonction de la cellule ß pancréatique Diabetes & Metabolism. 39. DOI: 10.1016/S1262-3636(13)71662-8 | 0.554 | |||
| 2013 | Saeed S, Butt TA, Anwer M, Arslan M, Froguel P. Corrigendum to "High prevalence of leptin and melanocotin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families" [Mol. Genet. Metab. 106/1 (2012) 121-126] Molecular Genetics and Metabolism. 109: 404. DOI: 10.1016/J.Ymgme.2013.05.015 | 0.381 | |||
| 2012 | Brajkovic S, Marenzoni R, Favre D, Guérardel A, Salvi R, Beeler N, Froguel P, Vollenweider P, Waeber G, Abderrahmani A. Evidence for tuning adipocytes ICER levels for obesity care. Adipocyte. 1: 157-160. PMID 23700525 DOI: 10.4161/adip.20000 | 0.611 | |||
| 2012 | Amara A, Chadli-Chaieb M, Ghezaiel H, Philippe J, Brahem R, Dechaume A, Saad A, Chaieb L, Froguel P, Froguele P, Gribaa M, Vaxillaire M. Familial early-onset diabetes is not a typical MODY in several Tunisian patients. La Tunisie Mã©Dicale. 90: 882-7. PMID 23247789 | 0.681 | |||
| 2012 | van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, ... ... Froguel P, et al. Seventy-five genetic loci influencing the human red blood cell. Nature. 492: 369-75. PMID 23222517 DOI: 10.1038/Nature11677 | 0.313 | |||
| 2012 | Morandi A, Meyre D, Lobbens S, Kleinman K, Kaakinen M, Rifas-Shiman SL, Vatin V, Gaget S, Pouta A, Hartikainen AL, Laitinen J, Ruokonen A, Das S, Khan AA, Elliott P, ... ... Froguel P, et al. Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts. Plos One. 7: e49919. PMID 23209618 DOI: 10.1371/Journal.Pone.0049919 | 0.327 | |||
| 2012 | Froguel P, Marquez M, Cauchi S. Response to comment on: Marquez et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2012;61:524-530. Diabetes. 61: e15. PMID 22923658 DOI: 10.2337/Db12-0800 | 0.398 | |||
| 2012 | Bacquer OL, Kerr-Conte J, Gargani S, Delalleau N, Huyvaert M, Gmyr V, Froguel P, Neve B, Pattou F. TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals. Diabetologia. 55: 2677-2681. PMID 22911383 DOI: 10.1007/S00125-012-2660-8 | 0.414 | |||
| 2012 | Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, ... ... Froguel P, et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics. 44: 991-1005. PMID 22885924 DOI: 10.1038/Ng.2385 | 0.431 | |||
| 2012 | Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, ... ... Froguel P, et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics. 44: 981-90. PMID 22885922 DOI: 10.1038/Ng.2383 | 0.414 | |||
| 2012 | Bonnefond A, Sand O, Guerin B, Durand E, De Graeve F, Huyvaert M, Rachdi L, Kerr-Conte J, Pattou F, Vaxillaire M, Polak M, Scharfmann R, Czernichow P, Froguel P. GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes. Diabetologia. 55: 2845-7. PMID 22806356 DOI: 10.1007/S00125-012-2645-7 | 0.603 | |||
| 2012 | Bonnefond A, Philippe J, Durand E, Dechaume A, Huyvaert M, Montagne L, Marre M, Balkau B, Fajardy I, Vambergue A, Vatin V, Delplanque J, Le Guilcher D, De Graeve F, Lecoeur C, ... ... Froguel P, et al. Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene. Plos One. 7: e37423. PMID 22701567 DOI: 10.1371/Journal.Pone.0037423 | 0.802 | |||
| 2012 | Billings LK, Hsu YH, Ackerman RJ, Dupuis J, Voight BF, Rasmussen-Torvik LJ, Hercberg S, Lathrop M, Barnes D, Langenberg C, Hui J, Fu M, Bouatia-Naji N, Lecoeur C, An P, ... ... Froguel P, et al. Impact of common variation in bone-related genes on type 2 diabetes and related traits. Diabetes. 61: 2176-86. PMID 22698912 DOI: 10.2337/Db11-1515 | 0.438 | |||
| 2012 | Perry JR, Voight BF, Yengo L, Amin N, Dupuis J, Ganser M, Grallert H, Navarro P, Li M, Qi L, Steinthorsdottir V, Scott RA, Almgren P, Arking DE, Aulchenko Y, ... ... Froguel P, et al. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. Plos Genetics. 8: e1002741. PMID 22693455 DOI: 10.1371/Journal.Pgen.1002741 | 0.449 | |||
| 2012 | Boutant M, Ramos OH, Lecoeur C, Vaillant E, Philippe J, Zhang P, Perilhou A, Valcarcel B, Sebert S, Jarvelin MR, Balkau B, Scott D, Froguel P, Vaxillaire M, Vasseur-Cognet M. Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity. Plos One. 7: e35810. PMID 22606236 DOI: 10.1371/Journal.Pone.0035810 | 0.684 | |||
| 2012 | El-Sayed Moustafa JS, Eleftherohorinou H, de Smith AJ, Andersson-Assarsson JC, Alves AC, Hadjigeorgiou E, Walters RG, Asher JE, Bottolo L, Buxton JL, Sladek R, Meyre D, Dina C, Visvikis-Siest S, Jacobson P, ... ... Froguel P, et al. Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity. Human Molecular Genetics. 21: 3727-38. PMID 22595969 DOI: 10.1093/Hmg/Dds187 | 0.402 | |||
| 2012 | Wolowczuk I, Hennart B, Leloire A, Bessede A, Soichot M, Taront S, Caiazzo R, Raverdy V, Pigeyre M, Guillemin GJ, Allorge D, Pattou F, Froguel P, Poulain-Godefroy O. Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 303: R135-43. PMID 22592557 DOI: 10.1152/Ajpregu.00373.2011 | 0.333 | |||
| 2012 | Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, ... ... Froguel P, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics. 44: 659-69. PMID 22581228 DOI: 10.1038/Ng.2274 | 0.398 | |||
| 2012 | Vaxillaire M, Bonnefond A, Froguel P. The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis. Best Practice & Research. Clinical Endocrinology & Metabolism. 26: 171-87. PMID 22498247 DOI: 10.1016/J.Beem.2011.12.001 | 0.622 | |||
| 2012 | Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher FR, Cousminer DL, Sleiman PM, Zhao J, ... ... Froguel P, et al. A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics. 44: 526-31. PMID 22484627 DOI: 10.1038/Ng.2247 | 0.399 | |||
| 2012 | Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, ... ... Froguel P, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Plos Genetics. 8: e1002607. PMID 22479202 DOI: 10.1371/Journal.Pgen.1002607 | 0.774 | |||
| 2012 | Cauchi S, Ezzidi I, Achhab YE, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P. European genetic variants associated with type 2 diabetes in North African Arabs Diabetes & Metabolism. 38: 316-323. PMID 22463974 DOI: 10.1016/J.Diabet.2012.02.003 | 0.395 | |||
| 2012 | Saeed S, Butt TA, Anwer M, Arslan M, Froguel P. High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Molecular Genetics and Metabolism. 106: 121-6. PMID 22463805 DOI: 10.1016/J.Ymgme.2012.03.001 | 0.401 | |||
| 2012 | Rouskas K, Meyre D, Stutzmann F, Paletas K, Papazoglou D, Vatin V, Marchand M, Kouvatsi A, Froguel P. Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population. Obesity (Silver Spring, Md.). 20: 2278-82. PMID 22447289 DOI: 10.1038/Oby.2012.77 | 0.789 | |||
| 2012 | Scott RA, Chu AY, Grarup N, Manning AK, Hivert MF, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, ... ... Froguel P, et al. No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes. 61: 1291-6. PMID 22415877 DOI: 10.2337/Db11-0973 | 0.373 | |||
| 2012 | Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, Soukaseum C, Mandet C, Broux F, Chabre O, ... ... Froguel P, et al. KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nature Genetics. 44: 456-60, S1-3. PMID 22406640 DOI: 10.1038/Ng.2218 | 0.554 | |||
| 2012 | Froguel P, Ndiaye NC, Bonnefond A, Bouatia-Naji N, Dechaume A, Siest G, Herbeth B, Falchi M, Bottolo L, Guéant-Rodriguez RM, Lecoeur C, Langlois MR, Labrune Y, Ruokonen A, El Shamieh S, et al. A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. Plos One. 7: e32327. PMID 22403646 DOI: 10.1371/Journal.Pone.0032327 | 0.592 | |||
| 2012 | Beulens JW, van der Schouw YT, Bergmann MM, Rohrmann S, Schulze MB, Buijsse B, Grobbee DE, Arriola L, Cauchi S, Tormo MJ, Allen NE, van der A DL, Balkau B, Boeing H, Clavel-Chapelon F, ... ... Froguel P, et al. Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. Journal of Internal Medicine. 272: 358-70. PMID 22353562 DOI: 10.1111/J.1365-2796.2012.02532.X | 0.317 | |||
| 2012 | Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, ... ... Froguel P, et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 483: 350-4. PMID 22343897 DOI: 10.1038/Nature10798 | 0.597 | |||
| 2012 | Bonnefond A, Clément N, Fawcett K, Yengo L, Vaillant E, Guillaume JL, Dechaume A, Payne F, Roussel R, Czernichow S, Hercberg S, Hadjadj S, Balkau B, Marre M, Lantieri O, ... ... Froguel P, et al. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nature Genetics. 44: 297-301. PMID 22286214 DOI: 10.1038/Ng.1053 | 0.608 | |||
| 2012 | Panagiotou OA, Ioannidis JPA, Hirschhorn JN, Abecasis GR, Frayling TM, McCarthy MI, Lindgren CM, Beaty TH, Eriksson N, Polychronakos C, Kathirensan S, Plenge RM, Spritz R, Payami H, Martin ER, ... ... Froguel P, et al. What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations International Journal of Epidemiology. 41: 273-286. PMID 22253303 DOI: 10.1093/Ije/Dyr178 | 0.316 | |||
| 2012 | Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, Ferrara A, ... ... Froguel P, et al. A genome-wide association search for type 2 diabetes genes in African Americans. Plos One. 7: e29202. PMID 22238593 DOI: 10.1371/Journal.Pone.0029202 | 0.774 | |||
| 2012 | Riveline JP, Rousseau E, Reznik Y, Fetita S, Philippe J, Dechaume A, Hartemann A, Polak M, Petit C, Charpentier G, Gautier JF, Froguel P, Vaxillaire M. Clinical and metabolic features of adult-onset diabetes caused by ABCC8 mutations. Diabetes Care. 35: 248-51. PMID 22210575 DOI: 10.2337/Dc11-1469 | 0.708 | |||
| 2012 | Marquez M, Huyvaert M, Perry JR, Pearson RD, Falchi M, Morris AP, Vivequin S, Lobbens S, Yengo L, Gaget S, Pattou F, Poulain-Godefroy O, Charpentier G, Carlsson LM, Jacobson P, ... ... Froguel P, et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes. 61: 524-30. PMID 22210315 DOI: 10.2337/Db11-0728 | 0.419 | |||
| 2012 | Creemers JW, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S, Meulemans S, Than ME, Yengo L, Tauber M, Balkau B, Elliott P, Jarvelin MR, Van Hul W, Van Gaal L, ... ... Froguel P, et al. Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes. 61: 383-90. PMID 22210313 DOI: 10.2337/Db11-0305 | 0.38 | |||
| 2012 | Anveden Å, Sjöholm K, Jacobson P, Palsdottir V, Walley AJ, Froguel P, Al-Daghri N, McTernan PG, Mejhert N, Arner P, Sjöström L, Carlsson LM, Svensson PA. ITIH-5 expression in human adipose tissue is increased in obesity. Obesity (Silver Spring, Md.). 20: 708-14. PMID 21852814 DOI: 10.1038/Oby.2011.268 | 0.32 | |||
| 2012 | Clark SJ, Falchi M, Olsson B, Jacobson P, Cauchi S, Balkau B, Marre M, Lantieri O, Andersson JC, Jernås M, Aitman TJ, Richardson S, Sjöström L, Wong HY, Carlsson LM, ... Froguel P, et al. Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity (Silver Spring, Md.). 20: 178-85. PMID 21760635 DOI: 10.1038/Oby.2011.200 | 0.375 | |||
| 2012 | Rouskas K, Kouvatsi A, Paletas K, Papazoglou D, Tsapas A, Lobbens S, Vatin V, Durand E, Labrune Y, Delplanque J, Meyre D, Froguel P. Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the greek population Obesity. 20: 389-395. PMID 21720444 DOI: 10.1038/Oby.2011.177 | 0.725 | |||
| 2012 | Dorajoo R, Blakemore AI, Sim X, Ong RT, Ng DP, Seielstad M, Wong TY, Saw SM, Froguel P, Liu J, Tai ES. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. International Journal of Obesity (2005). 36: 159-63. PMID 21544081 DOI: 10.1038/Ijo.2011.86 | 0.418 | |||
| 2012 | Walley AJ, Jacobson P, Falchi M, Bottolo L, Andersson JC, Petretto E, Bonnefond A, Vaillant E, Lecoeur C, Vatin V, Jernas M, Balding D, Petteni M, Park YS, Aitman T, ... ... Froguel P, et al. Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue. International Journal of Obesity (2005). 36: 137-47. PMID 21427694 DOI: 10.1038/Ijo.2011.22 | 0.6 | |||
| 2012 | Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, Soukaseum C, Mandet C, Broux F, Chabre O, ... ... Froguel P, et al. Erratum: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron (Nature Genetics (2012) 44 (458-462)) Nature Genetics. 44. DOI: 10.1038/Ng0512-609 | 0.539 | |||
| 2012 | Polak M, Cavé H, Busiah K, Bonnefond A, Simon A, Flechtner I, Dechaume A, Pouvreau N, Gerard B, Scharfmann R, Froguel P, Vaxillaire M. Diabète néonatal (monogénique de la très petite enfance). État des travaux du Réseau Français d’étude du diabète néonatal. Diabetes & Metabolism. 38. DOI: 10.1016/S1262-3636(12)71525-2 | 0.555 | |||
| 2012 | Perimenis P, Bouckenooghe T, Eury E, Lobbens S, Delplanque J, Moitrot E, Gosset P, Sisino G, Storme L, Froguel P, Vambergue A. O67 L’analyse du transcriptome montre une dysfonction foeto-placentaire au cours du diabète maternel Diabetes & Metabolism. 38: A17. DOI: 10.1016/S1262-3636(12)71045-5 | 0.682 | |||
| 2012 | Vaxillaire M, Bonnefond A, Philippe J, Durand E, Dechaume A, Vaillant E, Montagne L, Huyvaert M, Lecoeur C, Graeve FD, Sand O, Froguel P. O58 Une nouvelle cause curable de MODY et de DT2 de l’adulte jeune révélée par une mutation de KCNJ11, codant la sous-unité Kir6.2 du canal potassique ATP-dépendant Diabetes & Metabolism. 38. DOI: 10.1016/S1262-3636(12)71036-4 | 0.748 | |||
| 2012 | Bonnefond A, Poulain-Godefroy O, Ichimura A, Hirasawa A, Yengo L, Leloire A, Choquet H, Meyre D, Pattou F, Wolowczuk I, Tsujimoto G, Froguel P. O53 L’altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l’Homme et la Souris Diabetes & Metabolism. 38. DOI: 10.1016/S1262-3636(12)71031-5 | 0.55 | |||
| 2012 | Perimenis P, Bouckenooghe T, Eury E, Lobbens S, Delplanque J, Moitrot E, Gosset P, Sisino G, Storme L, Fontaine P, Froguel P, Vambergue A. Augmentation de l’expression de la prolactine placentaire dans un modèle de rate gestante diabétique Annales D'Endocrinologie. 73: 251. DOI: 10.1016/J.Ando.2012.07.067 | 0.645 | |||
| 2011 | Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Pirastu N, ... ... Froguel P, et al. New gene functions in megakaryopoiesis and platelet formation. Nature. 480: 201-8. PMID 22139419 DOI: 10.1038/Nature10659 | 0.546 | |||
| 2011 | Kilpeläinen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, Ahmad T, Mora S, Kaakinen M, Sandholt CH, Holzapfel C, Autenrieth CS, Hyppönen E, Cauchi S, He M, ... ... Froguel P, et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. Plos Medicine. 8: e1001116. PMID 22069379 DOI: 10.1371/Journal.Pmed.1001116 | 0.357 | |||
| 2011 | Semplici F, Vaxillaire M, Fogarty S, Semache M, Bonnefond A, Fontés G, Philippe J, Meur G, Diraison F, Sessions RB, Rutter J, Poitout V, Froguel P, Rutter GA. Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. The Journal of Biological Chemistry. 286: 44005-14. PMID 22065581 DOI: 10.1074/Jbc.M111.254995 | 0.769 | |||
| 2011 | Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, ... ... Froguel P, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics. 43: 1131-8. PMID 22001757 DOI: 10.1038/Ng.970 | 0.317 | |||
| 2011 | Gautier A, Roussel R, Lange C, Piguel X, Cauchi S, Vol S, Froguel P, Balkau B, Bonnet F. Effects of genetic susceptibility for type 2 diabetes on the evolution of glucose homeostasis traits before and after diabetes diagnosis: data from the D.E.S.I.R. Study. Diabetes. 60: 2654-63. PMID 21911746 DOI: 10.2337/Db10-1442 | 0.422 | |||
| 2011 | Jacquemont S, Reymond A, Zufferey F, Harewood L, Walters RG, Kutalik Z, Martinet D, Shen Y, Valsesia A, Beckmann ND, Thorleifsson G, Belfiore M, Bouquillon S, Campion D, de Leeuw N, ... ... Froguel P, et al. Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature. 478: 97-102. PMID 21881559 DOI: 10.1038/Nature10406 | 0.395 | |||
| 2011 | Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, Been LF, Chia KS, Dimas AS, Hassanali N, Jafar T, Jowett JB, Li X, Radha V, Rees SD, ... ... Froguel P, et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nature Genetics. 43: 984-9. PMID 21874001 DOI: 10.1038/Ng.921 | 0.418 | |||
| 2011 | Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, ... ... Froguel P, et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes. 60: 2624-34. PMID 21873549 DOI: 10.2337/Db11-0415 | 0.428 | |||
| 2011 | Thanabalasingham G, Shah N, Vaxillaire M, Hansen T, Tuomi T, Gašperíková D, Szopa M, Tjora E, James TJ, Kokko P, Loiseleur F, Andersson E, Gaget S, Isomaa B, Nowak N, ... ... Froguel P, et al. A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. Diabetologia. 54: 2801-10. PMID 21814873 DOI: 10.1007/S00125-011-2261-Y | 0.35 | |||
| 2011 | Pound LD, Sarkar SA, Cauchi S, Wang Y, Oeser JK, Lee CE, Froguel P, Hutton JC, O'Brien RM. Characterization of the human SLC30A8 promoter and intronic enhancer. Journal of Molecular Endocrinology. 47: 251-9. PMID 21798992 DOI: 10.1530/Jme-11-0055 | 0.385 | |||
| 2011 | Langenberg C, Sharp S, Forouhi NG, Franks PW, Schulze MB, Kerrison N, Ekelund U, Barroso I, Panico S, Tormo MJ, Spranger J, Griffin S, van der Schouw YT, Amiano P, ... ... Froguel P, et al. Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia. 54: 2272-82. PMID 21717116 DOI: 10.1007/S00125-011-2182-9 | 0.385 | |||
| 2011 | Bonnefond A, Lomberk G, Buttar N, Busiah K, Vaillant E, Lobbens S, Yengo L, Dechaume A, Mignot B, Simon A, Scharfmann R, Neve B, Tanyolaç S, Hodoglugil U, Pattou F, ... ... Froguel P, et al. Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. The Journal of Biological Chemistry. 286: 28414-24. PMID 21592955 DOI: 10.1074/Jbc.M110.215822 | 0.61 | |||
| 2011 | Barker A, Sharp SJ, Timpson NJ, Bouatia-Naji N, Warrington NM, Kanoni S, Beilin LJ, Brage S, Deloukas P, Evans DM, Grontved A, Hassanali N, Lawlor DA, Lecoeur C, Loos RJ, ... ... Froguel P, et al. Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes. 60: 1805-12. PMID 21515849 DOI: 10.2337/Db10-1575 | 0.317 | |||
| 2011 | de Smith AJ, van Haelst MM, Ellis RJ, Holder SE, Payne SJ, Hashim SK, Froguel P, Blakemore AI. Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. American Journal of Medical Genetics. Part A. 155: 1192-5. PMID 21465662 DOI: 10.1002/Ajmg.A.33986 | 0.301 | |||
| 2011 | Séron K, Couturier C, Belouzard S, Bacart J, Monté D, Corset L, Bocquet O, Dam J, Vauthier V, Lecœur C, Bailleul B, Hoflack B, Froguel P, Jockers R, Rouillé Y. Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. The Journal of Biological Chemistry. 286: 17968-81. PMID 21454707 DOI: 10.1074/Jbc.M111.224857 | 0.76 | |||
| 2011 | Fernando MM, de Smith AJ, Coin L, Morris DL, Froguel P, Mangion J, Blakemore AI, Graham RR, Behrens TW, Vyse TJ. Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants. Annals of Human Genetics. 75: 383-97. PMID 21401563 DOI: 10.1111/J.1469-1809.2011.00641.X | 0.335 | |||
| 2011 | Peden JF, Hopewell JC, Saleheen D, Chambers JC, Hager J, Soranzo N, Collins R, Danesh J, Elliott P, Farrall M, Stirrups K, Zhang W, Hamsten A, Parish S, Lathrop M, ... ... Froguel P, et al. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease Nature Genetics. 43: 339-346. PMID 21378988 DOI: 10.1038/Ng.782 | 0.325 | |||
| 2011 | Bacquer OL, Shu L, Marchand M, Neve B, Paroni F, Conte JK, Pattou F, Froguel P, Maedler K. TCF7L2 splice variants have distinct effects on β-cell turnover and function Human Molecular Genetics. 20: 1906-1915. PMID 21357677 DOI: 10.1093/Hmg/Ddr072 | 0.32 | |||
| 2011 | Buxton JL, Walters RG, Visvikis-Siest S, Meyre D, Froguel P, Blakemore AI. Childhood obesity is associated with shorter leukocyte telomere length. The Journal of Clinical Endocrinology and Metabolism. 96: 1500-5. PMID 21349907 DOI: 10.1210/Jc.2010-2924 | 0.314 | |||
| 2011 | Gonsorcikova L, Vaxillaire M, Pruhova S, Dechaume A, Dusatkova P, Cinek O, Pedersen O, Froguel P, Hansen T, Lebl J. Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations Pediatric Diabetes. 12: 266-269. PMID 21214702 DOI: 10.1111/J.1399-5448.2010.00719.X | 0.374 | |||
| 2011 | Choquet H, Labrune Y, De Graeve F, Hinney A, Hebebrand J, Scherag A, Lecoeur C, Tauber M, Balkau B, Elliot P, Jarvelin MR, Walley AJ, Besnard P, Froguel P, Meyre D. Lack of association of CD36 SNPs with early onset obesity: a meta-analysis in 9,973 European subjects. Obesity (Silver Spring, Md.). 19: 833-9. PMID 20966904 DOI: 10.1038/Oby.2010.226 | 0.38 | |||
| 2011 | Olsson M, Olsson B, Jacobson P, Thelle DS, Björkegren J, Walley A, Froguel P, Carlsson LM, Sjöholm K. Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors. Metabolism: Clinical and Experimental. 60: 114-20. PMID 20619427 DOI: 10.1016/J.Metabol.2010.05.011 | 0.419 | |||
| 2011 | Wahlstrand B, Kellis D, Melander O, Svensson P, Walley A, Froguel P, Carlsson L, Hedner T, Jacobson P. Expression Of The Cardiovascular Susceptibility Gene Cdkn2B Is Up Regulated In Obesity And Associates With Factors Of The Metabolic Syndrome: 1D.02 Journal of Hypertension. 29. DOI: 10.1097/00004872-201106001-00034 | 0.355 | |||
| 2011 | Marquez M, Huyvaert M, Vivequin S, Lobbens S, Charpentier G, Balkau B, Froguel P, Cauchi S. P132 - Des variants peu fréquents dans le gène HMGA1 pourraient être associés au diabète de type 2 Diabetes & Metabolism. 37. DOI: 10.1016/S1262-3636(11)70758-3 | 0.362 | |||
| 2011 | Amara A, Ghezail H, Brahem R, Gribaa M, Philippe J, Dechaume A, Saad A, Chadli-Chaieb M, Chaieb L, Froguel P, Vaxillaire M. P126 - Absence de mutations des gènes HNF1A, HNF4A et INS chez dix patients tunisiens avec un diabète de type MODY Diabetes & Metabolism. 37. DOI: 10.1016/S1262-3636(11)70752-2 | 0.692 | |||
| 2011 | Gautier A, Roussel R, Lange C, Piguel X, Vol S, Cauchi S, Froguel P, Balkau B, Bonnet F. O86 Déclin accéléré de la fonction bêta en fonction du génotype TCF7L2 après le diagnostic de diabète dans la cohorte D.E.S.I.R. Diabetes & Metabolism. 37. DOI: 10.1016/S1262-3636(11)70574-2 | 0.357 | |||
| 2011 | Bacquer OL, Shu L, Marchand M, Neve B, Kerr-Conte J, Pattou F, Maedler K, Froguel P. O4 Splicing alternatif de TCF7L2 et fonction bêta-pancréatique Diabetes & Metabolism. 37. DOI: 10.1016/S1262-3636(11)70492-X | 0.3 | |||
| 2011 | Bonnefond A, Lomberk G, Busiah K, Vaillant E, Pattou F, Iovanna J, Stein R, Polak M, Vaxillaire M, Urrutia R, Froguel P. O2 L’extinction de la biosynthèse d’insuline via l’altération d’un site de fixation du facteur de transcription KLF11 entraîne une forme congénitale de diabète néonatal Diabetes & Metabolism. 37. DOI: 10.1016/S1262-3636(11)70490-6 | 0.558 | |||
| 2010 | Blakemore AIF, Froguel P. Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine. Annals of the New York Academy of Sciences. 1214: 180-189. PMID 21175686 DOI: 10.1111/J.1749-6632.2010.05880.X | 0.394 | |||
| 2010 | Bonnefond A, Durand E, Sand O, De Graeve F, Gallina S, Busiah K, Lobbens S, Simon A, Bellanné-Chantelot C, Létourneau L, Scharfmann R, Delplanque J, Sladek R, Polak M, Vaxillaire M, ... Froguel P, et al. Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome. Plos One. 5: e13630. PMID 21049026 DOI: 10.1371/Journal.Pone.0013630 | 0.763 | |||
| 2010 | Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, ... ... Froguel P, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics. 42: 937-48. PMID 20935630 DOI: 10.1038/Ng.686 | 0.396 | |||
| 2010 | Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, ... ... Froguel P, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics. 42: 949-60. PMID 20935629 DOI: 10.1038/Ng.685 | 0.335 | |||
| 2010 | Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, ... ... Froguel P, et al. Common variants at 10 genomic loci influence hemoglobin Aâ‚(C) levels via glycemic and nonglycemic pathways. Diabetes. 59: 3229-39. PMID 20858683 DOI: 10.2337/Db10-0502 | 0.599 | |||
| 2010 | Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Grarup N, Cauchi S, Ng DP, Ma RC, Tsunoda T, Kubo M, Watada H, ... ... Froguel P, et al. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature Genetics. 42: 864-8. PMID 20818381 DOI: 10.1038/Ng.660 | 0.397 | |||
| 2010 | Bonnefond A, Froguel P, Vaxillaire M. The emerging genetics of type 2 diabetes. Trends in Molecular Medicine. 16: 407-16. PMID 20728409 DOI: 10.1016/J.Molmed.2010.06.004 | 0.639 | |||
| 2010 | Ma L, Hanson RL, Traurig MT, Muller YL, Kaur BP, Perez JM, Meyre D, Fu M, Körner A, Franks PW, Kiess W, Kobes S, Knowler WC, Kovacs P, Froguel P, et al. Evaluation of A2BP1 as an obesity gene. Diabetes. 59: 2837-45. PMID 20724578 DOI: 10.2337/Db09-1604 | 0.401 | |||
| 2010 | Bouatia-Naji N, Bonnefond A, Baerenwald DA, Marchand M, Bugliani M, Marchetti P, Pattou F, Printz RL, Flemming BP, Umunakwe OC, Conley NL, Vaxillaire M, Lantieri O, Balkau B, Marre M, ... ... Froguel P, et al. Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. Diabetes. 59: 2662-71. PMID 20622168 DOI: 10.2337/Db10-0389 | 0.564 | |||
| 2010 | Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, ... ... Froguel P, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genetics. 42: 579-89. PMID 20581827 DOI: 10.1038/Ng.609 | 0.417 | |||
| 2010 | Coin LJ, Asher JE, Walters RG, Moustafa JS, de Smith AJ, Sladek R, Balding DJ, Froguel P, Blakemore AI. cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs. Nature Methods. 7: 541-6. PMID 20512141 DOI: 10.1038/Nmeth.1466 | 0.307 | |||
| 2010 | Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel CI, Müller TD, Grallert H, Wichmann HE, Balkau B, Heude B, Jarvelin MR, Hartikainen AL, Levy-Marchal C, Weill J, ... ... Froguel P, et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. Plos Genetics. 6: e1000916. PMID 20421936 DOI: 10.1371/Journal.Pgen.1000916 | 0.729 | |||
| 2010 | Bacart J, Leloire A, Levoye A, Froguel P, Jockers R, Couturier C. Evidence for leptin receptor isoforms heteromerization at the cell surface. Febs Letters. 584: 2213-7. PMID 20347812 DOI: 10.1016/J.Febslet.2010.03.033 | 0.772 | |||
| 2010 | Andersson EA, Holst B, Sparsø T, Grarup N, Banasik K, Holmkvist J, Jørgensen T, Borch-Johnsen K, Egerod KL, Lauritzen T, Sørensen TI, Bonnefond A, Meyre D, Froguel P, Schwartz TW, et al. MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes. 59: 1539-48. PMID 20200315 DOI: 10.2337/Db09-1757 | 0.618 | |||
| 2010 | Cauchi S, Guerra SD, Choquet H, D’Aleo V, Groves CJ, Lupi R, McCarthy MI, Froguel P, Marchetti P. Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets Molecular Genetics and Metabolism. 100: 77-82. PMID 20138556 DOI: 10.1016/J.Ymgme.2010.01.001 | 0.374 | |||
| 2010 | Bouhaha R, Baroudi T, Ennafaa H, Vaillant E, Abid H, Sassi R, Vatin V, Froguel P, Gaaied AB, Meyre D, Vaxillaire M. Study of TNFα -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population Clinical Biochemistry. 43: 549-552. PMID 20132806 DOI: 10.1016/J.Clinbiochem.2010.01.008 | 0.338 | |||
| 2010 | Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, Delobel B, Stutzmann F, El-Sayed Moustafa JS, Chèvre JC, Lecoeur C, ... ... Froguel P, et al. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature. 463: 671-5. PMID 20130649 DOI: 10.1038/Nature08727 | 0.8 | |||
| 2010 | Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, ... ... Froguel P, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics. 42: 105-16. PMID 20081858 DOI: 10.1038/Ng.520 | 0.785 | |||
| 2010 | Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, ... ... Froguel P, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genetics. 42: 142-8. PMID 20081857 DOI: 10.1038/Ng.521 | 0.765 | |||
| 2010 | Ghoussaini M, Stutzmann F, Couturier C, Vatin V, Durand E, Lecoeur C, Degraeve F, Heude B, Tauber M, Hercberg S, Levy-Marchal C, Tounian P, Weill J, Traurig M, Bogardus C, ... ... Froguel P, et al. Analysis of the SIM1 contribution to polygenic obesity in the French population. Obesity (Silver Spring, Md.). 18: 1670-5. PMID 20075856 DOI: 10.1038/Oby.2009.468 | 0.812 | |||
| 2010 | Grau K, Cauchi S, Holst C, Astrup A, Martinez JA, Saris WH, Blaak EE, Oppert JM, Arner P, Rössner S, Macdonald IA, Klimcakova E, Langin D, Pedersen O, Froguel P, et al. TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. The American Journal of Clinical Nutrition. 91: 472-9. PMID 20032493 DOI: 10.3945/Ajcn.2009.27947 | 0.344 | |||
| 2010 | Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V, Huffman JE, Igl W, Albrecht E, Deloukas P, Henderson J, ... ... Froguel P, et al. Genome-wide association study identifies five loci associated with lung function. Nature Genetics. 42: 36-44. PMID 20010834 DOI: 10.1038/Ng.501 | 0.677 | |||
| 2010 | Meur G, Simon A, Harun N, Virally M, Dechaume A, Bonnefond A, Fetita S, Tarasov AI, Guillausseau PJ, Boesgaard TW, Pedersen O, Hansen T, Polak M, Gautier JF, Froguel P, et al. Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention. Diabetes. 59: 653-61. PMID 20007936 DOI: 10.2337/Db09-1091 | 0.63 | |||
| 2010 | Cuesta-Muñoz AL, Tuomi T, Cobo-Vuilleumier N, Koskela H, Odili S, Stride A, Buettger C, Otonkoski T, Froguel P, Grimsby J, Garcia-Gimeno M, Matschinsky FM. Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY). Diabetes Care. 33: 290-292. PMID 19903754 DOI: 10.2337/Dc09-0681 | 0.367 | |||
| 2010 | Morandi A, Maffeis C, Lobbens S, Bouatia-Naji N, Heude B, Pinelli L, Meyre D, Froguel P. Early detrimental metabolic outcomes of rs17300539-A allele of ADIPOQ gene despite higher adiponectinemia. Obesity (Silver Spring, Md.). 18: 1469-73. PMID 19893502 DOI: 10.1038/Oby.2009.403 | 0.404 | |||
| 2010 | Corpeleijn E, Petersen L, Holst C, Saris WH, Astrup A, Langin D, MacDonald I, Martinez JA, Oppert J, Polak J, Pedersen O, Froguel P, Arner P, Sørensen TIA, Blaak EE. Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study Obesity. 18: 1369-1377. PMID 19876004 DOI: 10.1038/Oby.2009.377 | 0.352 | |||
| 2010 | Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, ... ... Froguel P, et al. Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes. 59: 311-8. PMID 19833892 DOI: 10.2337/Db09-0703 | 0.737 | |||
| 2010 | Bouhaha R, Choquet H, Meyre D, Kamoun HA, Ennafaa H, Baroudi T, Sassi R, Vaxillaire M, Elgaaied A, Froguel P, Cauchi S. TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia Pathologie Biologie. 58: 426-429. PMID 19286335 DOI: 10.1016/J.Patbio.2009.01.003 | 0.433 | |||
| 2010 | Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, ... ... Froguel P, et al. Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nature Genetics. 42: 464-464. DOI: 10.1038/Ng0510-464A | 0.777 | |||
| 2010 | Bacart J, Leloire A, Froguel P, Couturier C. P275 Les récepteurs à la leptine ont une organisation plus complexe que de simples homomères Diabetes & Metabolism. 36. DOI: 10.1016/S1262-3636(10)70423-7 | 0.769 | |||
| 2010 | Vaxillaire M, Busiah K, Bonnefond A, Lecoeur C, Dechaume A, Simon A, Graeve Fd, Gallina S, Delplanque J, Cavé H, Polak M, Froguel P. P210 Nouvelles Approches dans l’Étude des Diabètes Monogéniques chez l’Enfant et l’Adulte Jeune, et Distribution des Étiologies Génétiques à partir de la Cohorte du Réseau d’Étude Français Diabetes & Metabolism. 36. DOI: 10.1016/S1262-3636(10)70358-X | 0.748 | |||
| 2010 | Cauchi S, Lobbens S, Graeve Fd, Delplanque J, Achhab YE, Chikri M, Froguel P. P208 Quels Sont Les Facteurs Génétiques Associés Au Diabète De Type 2 Chez Les Marocains Diabetes & Metabolism. 36. DOI: 10.1016/S1262-3636(10)70356-6 | 0.677 | |||
| 2010 | Stutzmann F, Keller R, Labrune Y, Durand E, Calvacanti-Proença C, Potoczna N, Horber F, Meyre D, Froguel P. O88 Variabilité de l’effet de la chirurgie bariatrique en fonction du génotype de MC4R Diabetes & Metabolism. 36. DOI: 10.1016/S1262-3636(10)70092-6 | 0.769 | |||
| 2010 | Bonnefond A, Lomberk G, Busiah K, Dechaume A, Pereira S, Simon A, Cavé H, Mignot B, Polak M, Urrutia R, Froguel P, Vaxillaire M. O9 L’Extinction de l’Activité du Promoteur du Gène de l’Insuline Entraîne une Forme Congénitale de Diabète Néonatal Transitoire Diabetes & Metabolism. 36. DOI: 10.1016/S1262-3636(10)70013-6 | 0.563 | |||
| 2010 | Choquet H, Creemers J, Pigeyre M, Vatin V, Balkau B, Jarvelin M, Horber F, Van Hul W, Van Gaal L, Pattou F, Froguel P, Meyre D. O8 Une déficience partielle en prohormone convertase 1 confère une augmentation du risque de l’obésité Diabetes & Metabolism. 36: A2-A3. DOI: 10.1016/S1262-3636(10)70012-4 | 0.305 | |||
| 2010 | Cauchi S, Froguel P. Identification of genetic factors associated with Type 2 Diabetes in Saudis: The lessons from European studies International Journal of Diabetes Mellitus. 2: 133-136. DOI: 10.1016/J.Ijdm.2010.05.013 | 0.396 | |||
| 2009 | Vaxillaire M, Froguel P. Monogenic forms of diabetes mellitus: an update Endocrinología Y NutricióN. 56: 26-29. PMID 20542223 DOI: 10.1016/S1575-0922(09)73513-2 | 0.355 | |||
| 2009 | Bouatia-Naji N, Bonnefond A, Froguel P. [Inputs from the genetics of fasting glucose: lessons for diabetes]. Medecine Sciences : M/S. 25: 897-902. PMID 19951660 DOI: 10.1051/Medsci/20092511897 | 0.598 | |||
| 2009 | Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, ... ... Froguel P, et al. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? Plos Genetics. 5: e1000694. PMID 19851442 DOI: 10.1371/Journal.Pgen.1000694 | 0.383 | |||
| 2009 | Fernandez-Zapico ME, van Velkinburgh JC, Gutiérrez-Aguilar R, Neve B, Froguel P, Urrutia R, Stein R. MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. The Journal of Biological Chemistry. 284: 36482-90. PMID 19843526 DOI: 10.1074/Jbc.M109.028852 | 0.714 | |||
| 2009 | Clerc SL, Limou S, Coulonges C, Carpentier W, Dina C, Taing L, Delaneau O, Labib T, Sladek R, Group AG, Deveau C, Guillemain H, Ratsimandresy R, Montes M, Spadoni JL, ... ... Froguel P, et al. Genomewide Association Study of a Rapid Progression Cohort Identifies New Susceptibility Alleles for AIDS (ANRS Genomewide Association Study 03) Journal of Infectious Diseases. 200: 1194-1201. PMID 19754311 DOI: 10.1086/605892 | 0.305 | |||
| 2009 | Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, ... ... Froguel P, et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nature Genetics. 41: 1110-5. PMID 19734900 DOI: 10.1038/Ng.443 | 0.428 | |||
| 2009 | Bonnefond A, Vaxillaire M, Labrune Y, Lecoeur C, Chèvre JC, Bouatia-Naji N, Cauchi S, Balkau B, Marre M, Tichet J, Riveline JP, Hadjadj S, Gallois Y, Czernichow S, Hercberg S, ... ... Froguel P, et al. Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits. Diabetes. 58: 2687-97. PMID 19651813 DOI: 10.2337/Db09-0652 | 0.556 | |||
| 2009 | Chambers JC, Zhang W, Zabaneh D, Sehmi J, Jain P, McCarthy MI, Froguel P, Ruokonen A, Balding D, Jarvelin MR, Scott J, Elliott P, Kooner JS. Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes. 58: 2703-8. PMID 19651812 DOI: 10.2337/Db08-1805 | 0.374 | |||
| 2009 | Saiki A, Olsson M, Jernås M, Gummesson A, McTernan PG, Andersson J, Jacobson P, Sjöholm K, Olsson B, Yamamura S, Walley A, Froguel P, Carlsson B, Sjöström L, Svensson PA, et al. Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. The Journal of Clinical Endocrinology and Metabolism. 94: 3987-94. PMID 19602561 DOI: 10.1210/Jc.2009-0292 | 0.323 | |||
| 2009 | Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, Meyre D, Golzio C, Molinari F, Kadhom N, Etchevers HC, Saudek V, Farooqi IS, Froguel P, Lindahl T, et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. American Journal of Human Genetics. 85: 106-11. PMID 19559399 DOI: 10.1016/J.Ajhg.2009.06.002 | 0.362 | |||
| 2009 | Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 58: 2070-83. PMID 19542200 DOI: 10.2337/Db09-0551 | 0.36 | |||
| 2009 | Walley AJ, Asher JE, Froguel P. The genetic contribution to non-syndromic human obesity Nature Reviews Genetics. 10: 431-442. PMID 19506576 DOI: 10.1038/Nrg2594 | 0.396 | |||
| 2009 | de Smith AJ, Purmann C, Walters RG, Ellis RJ, Holder SE, Van Haelst MM, Brady AF, Fairbrother UL, Dattani M, Keogh JM, Henning E, Yeo GS, O'Rahilly S, Froguel P, Farooqi IS, et al. A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Human Molecular Genetics. 18: 3257-65. PMID 19498035 DOI: 10.1093/Hmg/Ddp263 | 0.377 | |||
| 2009 | Traurig M, Mack J, Hanson RL, Ghoussaini M, Meyre D, Knowler WC, Kobes S, Froguel P, Bogardus C, Baier LJ. Common variation in SIM1 is reproducibly associated with BMI in Pima Indians Diabetes. 58: 1682-1689. PMID 19401419 DOI: 10.2337/Db09-0028 | 0.715 | |||
| 2009 | Goossens GH, Petersen L, Blaak EE, Hul G, Arner P, Astrup A, Froguel P, Patel K, Pedersen O, Polak J, Oppert JM, Martinez JA, Sørensen TI, Saris WH. Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study. International Journal of Obesity (2005). 33: 669-79. PMID 19399022 DOI: 10.1038/Ijo.2009.59 | 0.37 | |||
| 2009 | Vaxillaire M, D P, Bonnefond A, Froguel P. Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes. Pediatric Endocrinology Reviews : Per. 6: 405-17. PMID 19396026 | 0.581 | |||
| 2009 | Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, ... ... Froguel P, et al. Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes. 58: 1704-9. PMID 19389826 DOI: 10.2337/Db09-0081 | 0.333 | |||
| 2009 | Choquet H, Cavalcanti-Proença C, Lecoeur C, Dina C, Cauchi S, Vaxillaire M, Hadjadj S, Horber F, Potoczna N, Charpentier G, Ruiz J, Hercberg S, Maimaitiming S, Roussel R, Boenhnke M, ... ... Froguel P, et al. The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects. Human Molecular Genetics. 18: 2495-501. PMID 19377085 DOI: 10.1093/Hmg/Ddp169 | 0.387 | |||
| 2009 | Ezzidi I, Mtiraoui N, Cauchi S, Vaillant E, Dechaume A, Chaieb M, Kacem M, Almawi WY, Froguel P, Mahjoub T, Vaxillaire M. Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study. Bmc Medical Genetics. 10: 33. PMID 19368707 DOI: 10.1186/1471-2350-10-33 | 0.41 | |||
| 2009 | Jernås M, Olsson B, Arner P, Jacobson P, Sjöström L, Walley A, Froguel P, McTernan PG, Hoffstedt J, Carlsson LMS. Regulation of carboxylesterase 1 (CES1) in human adipose tissue. Biochemical and Biophysical Research Communications. 383: 63-67. PMID 19332024 DOI: 10.1016/J.Bbrc.2009.03.120 | 0.317 | |||
| 2009 | Sparsø T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, Wegner L, Grarup N, Gjesing AP, Banasik K, Cavalcanti-Proença C, Marchand M, Vaxillaire M, Charpentier G, Jarvelin MR, Tichet J, ... ... Froguel P, et al. G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes. 58: 1450-6. PMID 19324940 DOI: 10.2337/Db08-1660 | 0.616 | |||
| 2009 | Blakemore AIF, Meyre D, Delplanque J, Vatin V, Lecoeur C, Marre M, Tichet J, Balkau B, Froguel P, Walley AJ. A rare variant in the visfatin gene (nampt/pbef1) is associated with protection from obesity Obesity. 17: 1549-1553. PMID 19300429 DOI: 10.1038/Oby.2009.75 | 0.737 | |||
| 2009 | Dahlman I, Nilsson M, Gu HF, Lecoeur C, Efendic S, Östenson CG, Brismar K, Gustafsson J, Froguel P, Vaxillaire M, Dahlman-Wright K, Steffensen KR. Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles – a cohort study Bmc Medical Genetics. 10: 27-27. PMID 19292929 DOI: 10.1186/1471-2350-10-27 | 0.382 | |||
| 2009 | Carlsson LM, Jacobson P, Walley A, Froguel P, Sjöström L, Svensson PA, Sjöholm K. ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochemical and Biophysical Research Communications. 382: 309-14. PMID 19275893 DOI: 10.1016/J.Bbrc.2009.03.014 | 0.321 | |||
| 2009 | Cauchi S, Stutzmann F, Cavalcanti-Proença C, Durand E, Pouta A, Hartikainen AL, Marre M, Vol S, Tammelin T, Laitinen J, Gonzalez-Izquierdo A, Blakemore AI, Elliott P, Meyre D, Balkau B, ... ... Froguel P, et al. Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. Journal of Molecular Medicine (Berlin, Germany). 87: 537-46. PMID 19255736 DOI: 10.1007/S00109-009-0451-6 | 0.802 | |||
| 2009 | Bonnefond A, Bouatia-Naji N, Simon A, Saint-Martin C, Dechaume A, Lonlay Pd, Polak M, Bellanné-Chantelot C, Froguel P, Vaxillaire M. Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction Diabetologia. 52: 982-985. PMID 19238352 DOI: 10.1007/S00125-009-1299-6 | 0.607 | |||
| 2009 | Bossé Y, Bacot F, Montpetit A, Rung J, Qu HQ, Engert JC, Polychronakos C, Hudson TJ, Froguel P, Sladek R, Desrosiers M. Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans. Human Genetics. 125: 305-18. PMID 19184112 DOI: 10.1007/S00439-009-0626-9 | 0.341 | |||
| 2009 | Gueorguiev M, Lecoeur C, Meyre D, Benzinou M, Mein CA, Hinney A, Vatin V, Weill J, Heude B, Hebebrand J, Grossman AB, Korbonits M, Froguel P. Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity. Obesity. 17: 745-754. PMID 19165163 DOI: 10.1038/Oby.2008.589 | 0.418 | |||
| 2009 | Stutzmann F, Cauchi S, Durand E, Calvacanti-Proença C, Pigeyre M, Hartikainen AL, Sovio U, Tichet J, Marre M, Weill J, Balkau B, Potoczna N, Laitinen J, Elliott P, Järvelin MR, ... ... Froguel P, et al. Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. International Journal of Obesity (2005). 33: 373-8. PMID 19153581 DOI: 10.1038/ijo.2008.279 | 0.786 | |||
| 2009 | Meyre D, Delplanque J, Chèvre JC, Lecoeur C, Lobbens S, Gallina S, Durand E, Vatin V, Degraeve F, Proença C, Gaget S, Körner A, Kovacs P, Kiess W, Tichet J, ... ... Froguel P, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nature Genetics. 41: 157-9. PMID 19151714 DOI: 10.1038/Ng.301 | 0.727 | |||
| 2009 | Bouatia-Naji N, Marchand M, Cavalcanti-Proença C, Daghmoun S, Durand E, Tichet J, Marre M, Balkau B, Froguel P, Lévy-Marchal C. Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height. European Journal of Endocrinology. 160: 557-560. PMID 19139030 DOI: 10.1530/Eje-08-0794 | 0.333 | |||
| 2009 | Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, Labib T, Taing L, Sladek R, Deveau C, Ratsimandresy R, Montes M, Spadoni JL, Lelièvre JD, Lévy Y, ... ... Froguel P, et al. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS genomewide association study 02) Journal of Infectious Diseases. 199: 419-426. PMID 19115949 DOI: 10.1086/596067 | 0.321 | |||
| 2009 | Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, Marchand M, Delplanque J, Lobbens S, Rocheleau G, Durand E, De Graeve F, Chèvre JC, Borch-Johnsen K, Hartikainen AL, Ruokonen A, ... ... Froguel P, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nature Genetics. 41: 89-94. PMID 19060909 DOI: 10.1038/Ng.277 | 0.808 | |||
| 2009 | El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M. Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population Diabetes and Metabolism. 35: 37-42. PMID 19046915 DOI: 10.1016/J.Diabet.2008.06.005 | 0.756 | |||
| 2009 | Morandi A, Pinelli L, Petrone A, Vatin V, Buzzetti R, Froguel P, Meyre D. The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population. Obesity (Silver Spring, Md.). 17: 202-6. PMID 18948963 DOI: 10.1038/Oby.2008.470 | 0.396 | |||
| 2009 | Gueorguiev M, Lecoeur C, Benzinou M, Mein CA, Meyre D, Vatin V, Weill J, Heude B, Grossman AB, Froguel P, Korbonits M. A Genetic Study of the Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) Genes and Stature Annals of Human Genetics. 73: 1-9. PMID 18945286 DOI: 10.1111/J.1469-1809.2008.00484.X | 0.404 | |||
| 2009 | Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, ... ... Froguel P, et al. Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia Nature Genetics. 41: 1156-1156. DOI: 10.1038/Ng1009-1156C | 0.402 | |||
| 2009 | Bonnefond A, Bouatia-Naji N, Cavalcanti-Proença C, Marchand M, Oeser J, Lévy-Marchal C, Balkau B, Marre M, Pattou F, Jarvelin MR, O’Brien R, Froguel P. O98 Des variants du promoteur du gène G6PC2 pourraient expliquer la contribution de ce locus au contrôle génétique de la glycémie Diabetes & Metabolism. 35. DOI: 10.1016/S1262-3636(09)71790-2 | 0.562 | |||
| 2009 | Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Jarvelin MR, Charpentier G, Hadjadj S, Lévy-Marchal C, Balkau B, Marre M, Visvikis-Siest S, Pedersen O, Froguel P. O97 Des variants du gène MTNR1B du récepteur 2 à la mélatonine augmentent la glycémie et le risque de DT2 : un lien entre le rythme circadien et le diabète ? Diabetes & Metabolism. 35. DOI: 10.1016/S1262-3636(09)71789-6 | 0.539 | |||
| 2009 | Stutzmann F, Ghoussaini M, Couturier C, Vatin V, Corset L, Lecoeur C, Balkau B, Horber F, Weill J, Michaud J, Meyre D, Froguel P. O21 Des mutations du facteur de transcription hypothalamique SIM1 sont responsables d’obésité sévère monogénique de l’enfant Diabetes & Metabolism. 35. DOI: 10.1016/S1262-3636(09)71713-6 | 0.771 | |||
| 2009 | Vaxillaire M, Simon A, Bonnefond A, Virally M, Dechaume A, Busiah K, Cavé H, Scharfmann R, Rutter G, Gautier JF, Froguel P, Polak M. O5 Des mutations du gène de la préproinsuline altèrent la maturation de l’insuline et entraînent un diabète non auto-immun chez l’enfant et de type Mody Diabetes & Metabolism. 35. DOI: 10.1016/S1262-3636(09)71697-0 | 0.589 | |||
| 2008 | Durand E, Lecoeur C, Delplanque J, Benzinou M, Degraeve F, Boutin P, Marre M, Balkau B, Charpentier G, Froguel P, Meyre D. Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population Obesity Facts. 1: 305-309. PMID 20054193 DOI: 10.1159/000178157 | 0.74 | |||
| 2008 | de Smith AJ, Walters RG, Froguel P, Blakemore AI. Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease. Cytogenetic and Genome Research. 123: 17-26. PMID 19287135 DOI: 10.1159/000184688 | 0.326 | |||
| 2008 | Duesing K, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, Froguel P, Gibson F. Evaluating the association of common APOA2 variants with type 2 diabetes. Bmc Medical Genetics. 10: 13-13. PMID 19216768 DOI: 10.1186/1471-2350-10-13 | 0.402 | |||
| 2008 | Blakemore AIF, Froguel P. Is Obesity Our Genetic Legacy The Journal of Clinical Endocrinology and Metabolism. 93: 51-56. PMID 18987270 DOI: 10.1210/Jc.2008-1676 | 0.38 | |||
| 2008 | Dahlman I, Vaxillaire M, Nilsson M, Lecoeur C, Gu HF, Cavalcanti-Proença C, Efendic S, Östenson CG, Brismar K, Charpentier G, Gustafsson J, Froguel P, Dahlman-Wright K, Steffensen KR. Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose. Pharmacogenetics and Genomics. 18: 967-975. PMID 18854778 DOI: 10.1097/Fpc.0B013E32831101Ef | 0.386 | |||
| 2008 | de Smith AJ, Walters RG, Coin LJ, Steinfeld I, Yakhini Z, Sladek R, Froguel P, Blakemore AI. Small deletion variants have stable breakpoints commonly associated with alu elements. Plos One. 3: e3104. PMID 18769679 DOI: 10.1371/Journal.Pone.0003104 | 0.309 | |||
| 2008 | Froguel P, Blakemore AIF. The Power of the Extreme in Elucidating Obesity The New England Journal of Medicine. 359: 891-893. PMID 18753645 DOI: 10.1056/Nejmp0805396 | 0.338 | |||
| 2008 | Villalobos-Comparán M, Teresa Flores-Dorantes M, Teresa Villarreal-Molina M, Rodríguez-Cruz M, García-Ulloa AC, Robles L, Huertas-Vázquez A, Saucedo-Villarreal N, López-Alarcón M, Sánchez-Muñoz F, Domínguez-López A, Gutiérrez-Aguilar R, Menjivar M, Coral-Vázquez R, Hernández-Stengele G, ... ... Froguel P, et al. The FTO gene is associated with adulthood obesity in the Mexican population. Obesity (Silver Spring, Md.). 16: 2296-301. PMID 18719664 DOI: 10.1038/Oby.2008.367 | 0.744 | |||
| 2008 | Balkau B, Lange C, Fezeu L, Tichet J, de Lauzon-Guillain B, Czernichow S, Fumeron F, Froguel P, Vaxillaire M, Cauchi S, Ducimetière P, Eschwège E. Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care. 31: 2056-61. PMID 18689695 DOI: 10.2337/Dc08-0368 | 0.376 | |||
| 2008 | Bouhaha R, Meyre D, Kamoun HA, Ennafaa H, Vaillant E, Sassi R, Baroudi T, Vatin V, Froguel P, Elgaaied A, Vaxillaire M. Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population. Diabetes Research and Clinical Practice. 81: 278-83. PMID 18657335 DOI: 10.1016/j.diabres.2008.06.004 | 0.31 | |||
| 2008 | Benzinou M, Creemers JW, Choquet H, Lobbens S, Dina C, Durand E, Guerardel A, Boutin P, Jouret B, Heude B, Balkau B, Tichet J, Marre M, Potoczna N, Horber F, ... ... Froguel P, et al. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nature Genetics. 40: 943-5. PMID 18604207 DOI: 10.1038/Ng.177 | 0.401 | |||
| 2008 | Stutzmann F, Tan K, Vatin V, Dina C, Jouret B, Tichet J, Balkau B, Potoczna N, Horber F, O'Rahilly S, Farooqi IS, Froguel P, Meyre D. Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees. Diabetes. 57: 2511-8. PMID 18559663 DOI: 10.2337/Db08-0153 | 0.785 | |||
| 2008 | Vaxillaire M, Cavalcanti-Proença C, Dechaume A, Tichet J, Marre M, Balkau B, Froguel P. The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Diabetes. 57: 2253-2257. PMID 18556336 DOI: 10.2337/Db07-1807 | 0.367 | |||
| 2008 | Gutiérrez-Aguilar R, Froguel P, Hamid YH, Benmezroua Y, Jørgensen T, Borch-Johnsen K, Hansen T, Pedersen O, Neve B. Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C. The Journal of Clinical Endocrinology and Metabolism. 93: 3128-35. PMID 18505768 DOI: 10.1210/Jc.2007-2504 | 0.735 | |||
| 2008 | Cauchi S, Nead KT, Choquet H, Horber F, Potoczna N, Balkau B, Marre M, Charpentier G, Froguel P, Meyre D. The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies Bmc Medical Genetics. 9: 45-45. PMID 18498634 DOI: 10.1186/1471-2350-9-45 | 0.435 | |||
| 2008 | Cauchi S, Meyre D, Durand E, Proença C, Marre M, Hadjadj S, Choquet H, De Graeve F, Gaget S, Allegaert F, Delplanque J, Permutt MA, Wasson J, Blech I, Charpentier G, ... ... Froguel P, et al. Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value Plos One. 3. PMID 18461161 DOI: 10.1371/Journal.Pone.0002031 | 0.738 | |||
| 2008 | Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, Balding D, Scott J, Kooner JS. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nature Genetics. 40: 716-8. PMID 18454146 DOI: 10.1038/Ng.156 | 0.362 | |||
| 2008 | Bouatia-Naji N, Rocheleau G, Van Lommel L, Lemaire K, Schuit F, Cavalcanti-Proença C, Marchand M, Hartikainen AL, Sovio U, De Graeve F, Rung J, Vaxillaire M, Tichet J, Marre M, Balkau B, ... ... Froguel P, et al. A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (New York, N.Y.). 320: 1085-8. PMID 18451265 DOI: 10.1126/Science.1156849 | 0.379 | |||
| 2008 | Poulain-Godefroy O, Lecoeur C, Pattou F, Frühbeck G, Froguel P. Inflammation is associated with a decrease of lipogenic factors in omental fat in women American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 295. PMID 18448614 DOI: 10.1152/Ajpregu.00926.2007 | 0.309 | |||
| 2008 | Cauchi S, Froguel P. TCF7L2 genetic defect and type 2 diabetes. Current Diabetes Reports. 8: 149-155. PMID 18445358 DOI: 10.1007/S11892-008-0026-X | 0.424 | |||
| 2008 | Vaxillaire M, Froguel P. Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. Endocrine Reviews. 29: 254-264. PMID 18436708 DOI: 10.1210/Er.2007-0024 | 0.446 | |||
| 2008 | Duesing K, Fatemifar G, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, Froguel P, Gibson F. Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians Diabetes. 57: 1992-1996. PMID 18430866 DOI: 10.2337/Db07-1789 | 0.392 | |||
| 2008 | Martin D, Bellanné-Chantelot C, Deschamps I, Froguel P, Robert JJ, Velho G. Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2). Diabetes Care. 31: 1321-3. PMID 18411240 DOI: 10.2337/Dc07-2017 | 0.31 | |||
| 2008 | Wermter A, Scherag A, Meyre D, Reichwald K, Durand E, Nguyen TT, Koberwitz K, Lichtner P, Meitinger T, Schäfer H, Hinney A, Froguel P, Hebebrand J, Brönner G. Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children : first evidence of polar overdominance in humans European Journal of Human Genetics. 16: 1126-1134. PMID 18398438 DOI: 10.1038/Ejhg.2008.64 | 0.386 | |||
| 2008 | Bouatia-Naji N, Graeve FD, Brönner G, Lecoeur C, Vatin V, Durand E, Lichtner P, Nguyen TT, Heude B, Weill J, Lévy-Marchal C, Hebebrand J, Froguel P, Meyre D. INS VNTR is not associated with childhood obesity in 1,023 families: a family-based study. Obesity. 16: 1471-1475. PMID 18388898 DOI: 10.1038/Oby.2008.209 | 0.412 | |||
| 2008 | Benzinou M, Chèvre JC, Ward KJ, Lecoeur C, Dina C, Lobbens S, Durand E, Delplanque J, Horber FF, Heude B, Balkau B, Borch-johnsen K, Jørgensen T, Hansen T, Pedersen O, ... ... Froguel P, et al. Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations Human Molecular Genetics. 17: 1916-1921. PMID 18375449 DOI: 10.1093/Hmg/Ddn089 | 0.809 | |||
| 2008 | Duesing K, Fatemifar G, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, Froguel P, Gibson F. Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids. Diabetologia. 51: 821-826. PMID 18368387 DOI: 10.1007/S00125-008-0973-4 | 0.414 | |||
| 2008 | Tarasov AI, Nicolson TJ, Riveline JP, Taneja TK, Baldwin SA, Baldwin JM, Charpentier G, Gautier JF, Froguel P, Vaxillaire M, Rutter GA. A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Diabetes. 57: 1595-604. PMID 18346985 DOI: 10.2337/Db07-1547 | 0.325 | |||
| 2008 | Liu YJ, Liu XG, Wang L, Dina C, Yan H, Liu JF, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Meyre D, Delplanque J, Pei YF, Zhang L, Recker RR, ... Froguel P, et al. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Human Molecular Genetics. 17: 1803-13. PMID 18325910 DOI: 10.1093/Hmg/Ddn072 | 0.732 | |||
| 2008 | Meyre D, Farge M, Lecoeur C, Proenca C, Durand E, Allegaert F, Tichet J, Marre M, Balkau B, Weill J, Delplanque J, Froguel P. R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population Human Molecular Genetics. 17: 1798-1802. PMID 18325908 DOI: 10.1093/Hmg/Ddn070 | 0.73 | |||
| 2008 | Flechtner I, Vaxillaire M, Cavé H, Scharfmann R, Froguel P, Polak M. Neonatal hyperglycaemia and abnormal development of the pancreas Best Practice & Research Clinical Endocrinology & Metabolism. 22: 17-40. PMID 18279778 DOI: 10.1016/J.Beem.2007.08.003 | 0.393 | |||
| 2008 | Cauchi S, Choquet H, Gutiérrez-Aguilar R, Capel F, Grau K, Proença C, Dina C, Duval A, Balkau B, Marre M, Potoczna N, Langin D, Horber F, Sørensen TI, Charpentier G, ... ... Froguel P, et al. Effects of TCF7L2 polymorphisms on obesity in European populations. Obesity (Silver Spring, Md.). 16: 476-82. PMID 18239663 DOI: 10.1038/Oby.2007.77 | 0.74 | |||
| 2008 | Cauchi S, Proença C, Choquet H, Gaget S, Graeve FD, Marre M, Balkau B, Tichet J, Meyre D, Vaxillaire M, Froguel P. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. Journal of Molecular Medicine. 86: 341-348. PMID 18210030 DOI: 10.1007/S00109-007-0295-X | 0.412 | |||
| 2008 | Polak M, Dechaume A, Cavé H, Nimri R, Crosnier H, Sulmont V, Kerdanet Md, Scharfmann R, Lebenthal Y, Froguel P, Vaxillaire M. Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group. Diabetes. 57: 1115-1119. PMID 18171712 DOI: 10.2337/Db07-1358 | 0.409 | |||
| 2008 | Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, Dina C, Froguel P, Mohlke KL, Willer C, Olsson T, Wareham NJ, Hallmans G, Barroso I, Sandhu MS. Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia. 51: 458-63. PMID 18040659 DOI: 10.1007/S00125-007-0887-6 | 0.427 | |||
| 2008 | Vaxillaire M, Veslot J, Dina C, Proença C, Cauchi S, Charpentier G, Tichet J, Fumeron F, Marre M, Meyre D, Balkau B, Froguel P. Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study Diabetes. 57: 244-254. PMID 17977958 DOI: 10.2337/Db07-0615 | 0.42 | |||
| 2008 | Stunff CL, Dechartres A, Mariot V, Lotton C, Trainor C, Giudice EMD, Meyre D, Bieche I, Laurendeau I, Froguel P, Zelenika D, Fallin DD, Lathrop M, Roméo PH, Bougnères P. Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children. Diabetes. 57: 494-502. PMID 17977952 DOI: 10.2337/Db07-1273 | 0.373 | |||
| 2008 | Stunff CL, Dechartres A, Giudice EMD, Froguel P, Bougnères P. A Single-Nucleotide Polymorphism in the p110β Gene Promoter Is Associated with Partial Protection from Insulin Resistance in Severely Obese Adolescents The Journal of Clinical Endocrinology and Metabolism. 93: 212-215. PMID 17971428 DOI: 10.1210/Jc.2007-1822 | 0.394 | |||
| 2008 | Badii R, Bener A, Zirie M, Al-Rikabi A, Simsek M, Al-Hamaq AO, Ghoussaini M, Froguel P, Wareham NJ. Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population. Acta Diabetologica. 45: 15-21. PMID 17805473 DOI: 10.1007/S00592-007-0013-8 | 0.743 | |||
| 2008 | Mirhashemi F, Kluth O, Scherneck S, Vogel H, Kluge R, Schürmann A, Joost H, Neschen S, McDoniel SO, Nelson HA, Thomson CA, Durand E, Lecoeur C, Delplanque J, Benzinou M, ... ... Froguel P, et al. Contents Vol. 1, 2008 Obesity Facts. 1. DOI: 10.1159/000192785 | 0.624 | |||
| 2008 | Mirhashemi F, Kluth O, Scherneck S, Vogel H, Kluge R, Schürmann A, Joost H, Neschen S, McDoniel SO, Nelson HA, Thomson CA, Durand E, Lecoeur C, Delplanque J, Benzinou M, ... ... Froguel P, et al. Subject Index Vol. 1, 2008 Obesity Facts. 1: 342-342. DOI: 10.1159/000192783 | 0.642 | |||
| 2008 | Mirhashemi F, Kluth O, Scherneck S, Vogel H, Kluge R, Schürmann A, Joost H, Neschen S, McDoniel SO, Nelson HA, Thomson CA, Durand E, Lecoeur C, Delplanque J, Benzinou M, ... ... Froguel P, et al. Acknowledgement to Revierwers Obesity Facts. 1: 339-339. DOI: 10.1159/000192780 | 0.631 | |||
| 2008 | Mirhashemi F, Kluth O, Scherneck S, Vogel H, Kluge R, Schürmann A, Joost H, Neschen S, McDoniel SO, Nelson HA, Thomson CA, Durand E, Lecoeur C, Delplanque J, Benzinou M, ... ... Froguel P, et al. Meetings and Conferences Obesity Facts. 1: 117-118. DOI: 10.1159/000119750 | 0.641 | |||
| 2008 | Poulain-Godefroy O, Froguel P. Response to the letter to the editor: “HIF-1α protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity,” by Trayhurn et al. American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 295. DOI: 10.1152/Ajpregu.90722.2008 | 0.336 | |||
| 2008 | Riveline JP, Vaxillaire M, Fetita LS, Tarasov A, Nicolson T, Charpentier G, Franc S, Froguel P, Rutter GA, Gautier JF. P172 Conséquences métaboliques d’une nouvelle mutation du gène ABCC8/SUR1 présente chez un patient diabétique de type 2 adulte et sa descendance Diabetes & Metabolism. 34. DOI: 10.1016/S1262-3636(08)73084-2 | 0.323 | |||
| 2008 | Cauchi S, Nead K, Choquet H, Horber F, Potoczna N, Balkau B, Marre M, Charpentier G, Froguel P, Meyre D. O100 L’architecture génétique du diabète de type 2 est modulée par le statut d’obésité Diabetes & Metabolism. 34. DOI: 10.1016/S1262-3636(08)72910-0 | 0.365 | |||
| 2008 | Cauchi S, Meyre D, Hadjadj S, Charpentier G, Balkau B, Czernichow S, Patsch W, Chikri M, Glaser B, Sladek R, Froguel P. O25 Les nouveaux gènes associés au diabète de type 2 : impact dans des populations non européennes et mesure de leurs effets combinés Diabetes & Metabolism. 34. DOI: 10.1016/S1262-3636(08)72835-0 | 0.301 | |||
| 2008 | Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, Dina C, Froguel P, Mohlke KL, Willer C, Olsson T, Wareham NJ, Hallmans G, Barroso I, Sandhu MS. Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations (Diabetologia DOI: 10.1007/s00125-007-0887-6) Diabetologia. 51: 523. DOI: 10.1007/S00125-007-0907-6 | 0.374 | |||
| 2007 | Couturier C, Sarkis C, Séron K, Belouzard S, Chen P, Lenain A, Corset L, Dam J, Vauthier V, Dubart A, Mallet J, Froguel P, Rouillé Y, Jockers R. Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity Proceedings of the National Academy of Sciences of the United States of America. 104: 19476-19481. PMID 18042720 DOI: 10.1073/Pnas.0706671104 | 0.378 | |||
| 2007 | Porzio O, Massa O, Cunsolo V, Colombo C, Malaponti M, Bertuzzi F, Hansen T, Johansen A, Pedersen O, Meschi F, Terrinoni A, Melino G, Federici M, Decarlo N, Menicagli M, ... ... Froguel P, et al. Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online. Human Mutation. 28: 1150. PMID 17939176 DOI: 10.1002/humu.9511 | 0.318 | |||
| 2007 | Gutierrez-Aguilar R, Benmezroua Y, Balkau B, Marre M, Helbecque N, Charpentier G, Polychronakos C, Sladek R, Froguel P, Neve B. Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes Diabetes & Metabolism. 33: 372-378. PMID 17931948 DOI: 10.1016/J.Diabet.2007.06.002 | 0.749 | |||
| 2007 | Flechtner I, Vaxillaire M, Cavé H, Froguel P, Polak M. Diabète néonatal : une maladie aux multiples mécanismes Archives De Pediatrie. 14: 1356-1365. PMID 17931842 DOI: 10.1016/J.Arcped.2007.08.010 | 0.306 | |||
| 2007 | Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, Froguel P, Kadowaki T. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia. 50: 2461-6. PMID 17928989 DOI: 10.1007/S00125-007-0827-5 | 0.455 | |||
| 2007 | Saunders CL, Chiodini BD, Sham P, Lewis CM, Abkevich V, Adeyemo AA, de Andrade M, Arya R, Berenson GS, Blangero J, Boehnke M, Borecki IB, Chagnon YC, Chen W, Comuzzie AG, ... ... Froguel P, et al. Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (Silver Spring, Md.). 15: 2263-75. PMID 17890495 DOI: 10.1038/Oby.2007.269 | 0.356 | |||
| 2007 | Meyre D, Bouatia-Naji N, Vatin V, Veslot J, Samson C, Tichet J, Marre M, Balkau B, Froguel P. ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study. Diabetologia. 50: 2090-2096. PMID 17704904 DOI: 10.1007/S00125-007-0787-9 | 0.451 | |||
| 2007 | Ghoussaini M, Vatin V, Lecoeur C, Abkevich V, Younus A, Samson C, Wachter C, Heude B, Tauber M, Tounian P, Hercberg S, Weill J, Levy-Marchal C, Le Stunff C, Bougnères P, ... Froguel P, et al. Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. The Journal of Clinical Endocrinology and Metabolism. 92: 4403-9. PMID 17698913 DOI: 10.1210/Jc.2006-2316 | 0.673 | |||
| 2007 | Gutiérrez-Aguilar R, Benmezroua Y, Vaillant E, Balkau B, Marre M, Charpentier G, Sladek R, Froguel P, Neve B. Analysis of KLF transcription factor family gene variants in type 2 diabetes. Bmc Medical Genetics. 8: 53. PMID 17688680 DOI: 10.1186/1471-2350-8-53 | 0.731 | |||
| 2007 | Salonen JT, Uimari P, Aalto JM, Pirskanen M, Kaikkonen J, Todorova B, Hyppönen J, Korhonen VP, Asikainen J, Devine C, Tuomainen TP, Luedemann J, Nauck M, Kerner W, Stephens RH, ... ... Froguel P, et al. Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium American Journal of Human Genetics. 81: 338-345. PMID 17668382 DOI: 10.1086/520599 | 0.731 | |||
| 2007 | de Smith AJ, Tsalenko A, Sampas N, Scheffer A, Yamada NA, Tsang P, Ben-Dor A, Yakhini Z, Ellis RJ, Bruhn L, Laderman S, Froguel P, Blakemore AI. Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Human Molecular Genetics. 16: 2783-94. PMID 17666407 DOI: 10.1093/Hmg/Ddm208 | 0.331 | |||
| 2007 | Bouatia-Naji N, Vatin V, Lecoeur C, Heude B, Proença C, Veslot J, Jouret B, Tichet J, Charpentier G, Marre M, Balkau B, Froguel P, Meyre D. Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. Bmc Medical Genetics. 8: 44-44. PMID 17617923 DOI: 10.1186/1471-2350-8-44 | 0.407 | |||
| 2007 | Cauchi S, Meyre D, Choquet H, Deghmoun S, Durand E, Gaget S, Lecoeur C, Froguel P, Levy-Marchal C. TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population Bmc Medical Genetics. 8: 37-37. PMID 17593304 DOI: 10.1186/1471-2350-8-37 | 0.383 | |||
| 2007 | Stutzmann F, Vatin V, Cauchi S, Morandi A, Jouret B, Landt O, Tounian P, Levy-Marchal C, Buzzetti R, Pinelli L, Balkau B, Horber F, Bougnères P, Froguel P, Meyre D. Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Human Molecular Genetics. 16: 1837-44. PMID 17519222 DOI: 10.1093/Hmg/Ddm132 | 0.793 | |||
| 2007 | Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, ... ... Froguel P, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genetics. 39: 724-6. PMID 17496892 DOI: 10.1038/Ng2048 | 0.723 | |||
| 2007 | Cauchi S, Achhab YE, Choquet H, Dina C, Krempler F, Weitgasser R, Nejjari C, Patsch W, Chikri M, Meyre D, Froguel P. TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. Journal of Molecular Medicine. 85: 777-782. PMID 17476472 DOI: 10.1007/S00109-007-0203-4 | 0.4 | |||
| 2007 | Gueorguiev M, Wiltshire S, Garcia EA, Mein C, Lecoeur C, Kristen B, Allotey R, Hattersley AT, Walker M, O'rahilly S, Froguel P, Grossman AB, McCarthy MI, Hitman GA, Korbonits M. Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 92: 2201-4. PMID 17389697 DOI: 10.1210/Jc.2006-2657 | 0.401 | |||
| 2007 | Vaxillaire M, Dechaume A, Busiah K, Cave H, Pereira S, Scharfmann R, De Nanclares GP, Castano L, Froguel P, Polak M, Dundar B, Fernandez C, Fernandez-Rebollo E, Gonthier M, Lechuga JL, et al. New ABCC8 mutations in relapsing neonatal diabetes and clinical features Diabetes. 56: 1737-1741. PMID 17389331 DOI: 10.2337/Db06-1540 | 0.394 | |||
| 2007 | Valayannopoulos V, Vaxillaire M, Aigrain Y, Jaubert F, Bellanné-Chantelot C, Ribeiro MJ, Brunelle F, Froguel P, Robert JJ, Polak M, Nihoul-Fékété C, de Lonlay P. Coexistence in the same family of both focal and diffuse forms of hyperinsulinism. Diabetes Care. 30: 1590-2. PMID 17384337 DOI: 10.2337/Dc06-2327 | 0.335 | |||
| 2007 | Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, et al. Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes. 56: 879-83. PMID 17327460 DOI: 10.2337/Db06-0930 | 0.432 | |||
| 2007 | Chu WS, Das SK, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ, Jia W, McCarthy MI, Ng MCY, Damcott C, Shuldiner AR, Zeggini E, Elbein SC. Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits Diabetes. 56: 856-862. PMID 17327457 DOI: 10.2337/Db06-1305 | 0.407 | |||
| 2007 | Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, ... ... Froguel P, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 445: 881-5. PMID 17293876 DOI: 10.1038/Nature05616 | 0.446 | |||
| 2007 | Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, ... ... Froguel P, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine. 13: 332-9. PMID 17268472 DOI: 10.1038/Nm1557 | 0.314 | |||
| 2007 | Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T. A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia. 50: 747-751. PMID 17245589 DOI: 10.1007/S00125-006-0588-6 | 0.427 | |||
| 2007 | Dina C, Meyre D, Samson C, Tichet J, Marre M, Jouret B, Charles MA, Balkau B, Froguel P. Comment on "A common genetic variant is associated with adult and childhood obesity". Science (New York, N.Y.). 315: 187; author reply 18. PMID 17218508 DOI: 10.1126/Science.1129402 | 0.412 | |||
| 2007 | Bell CG, Meyre D, Petretto E, Levy-Marchal C, Hercberg S, Charles MA, Boyle C, Weill J, Tauber M, Mein CA, Aitman TJ, Froguel P, Walley AJ. No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases. European Journal of Human Genetics : Ejhg. 15: 320-7. PMID 17164796 DOI: 10.1038/Sj.Ejhg.5201754 | 0.629 | |||
| 2007 | Vasseur F, Guérardel A, Barat-Houari M, Cottel D, Amouyel P, Froguel P, Helbecque N. Impact of a CART promoter genetic variation on plasma lipid profile in a general population Molecular Genetics and Metabolism. 90: 199-204. PMID 17008116 DOI: 10.1016/J.Ymgme.2006.08.012 | 0.313 | |||
| 2006 | Vasseur F, Meyre D, Froguel P. Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. Expert Reviews in Molecular Medicine. 8: 1-12. PMID 17112391 DOI: 10.1017/S1462399406000147 | 0.475 | |||
| 2006 | Cauchi S, Vaxillaire M, Choquet H, Durand E, Duval A, Polak M, Froguel P. No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects Diabetologia. 50: 214-216. PMID 17093940 DOI: 10.1007/S00125-006-0505-Z | 0.438 | |||
| 2006 | Santos JL, Boutin P, Verdich C, Holst C, Larsen LH, Toubro S, Dina C, Saris WHM, Blaak EE, Hoffstedt J, Taylor MA, Polak J, Clement K, Langin D, Astrup A, ... Froguel P, et al. Genotype-by-nutrient interactions assessed in European obese women. A case-only study. European Journal of Nutrition. 45: 454-462. PMID 17080261 DOI: 10.1007/S00394-006-0619-6 | 0.383 | |||
| 2006 | Cauchi S, Meyre D, Choquet H, Dina C, Born C, Marre M, Balkau B, Froguel P. TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Diabetes. 55: 3189-3192. PMID 17065361 DOI: 10.2337/Db06-0692 | 0.378 | |||
| 2006 | Wiltshire S, Bell J, Groves CJ, Dina C, Hattersley AT, Frayling TM, Walker M, Hitman GA, Vaxillaire M, Farrall M, Froguel P, McCarthy MI. Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans Annals of Human Genetics. 70: 726-737. PMID 17044847 DOI: 10.1111/J.1469-1809.2006.00289.X | 0.314 | |||
| 2006 | Cauchi S, Meyre D, Dina C, Choquet H, Samson C, Gallina S, Balkau B, Charpentier G, Pattou F, Stetsyuk V, Scharfmann R, Staels B, Frühbeck G, Froguel P. Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes Diabetes. 55: 2903-2908. PMID 17003360 DOI: 10.2337/Db06-0474 | 0.452 | |||
| 2006 | Benzinou M, Walley A, Lobbens S, Charles MA, Jouret B, Fumeron F, Balkau B, Meyre D, Froguel P. Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians Diabetes. 55: 2876-2882. PMID 17003356 DOI: 10.2337/Db06-0337 | 0.458 | |||
| 2006 | Walley AJ, Blakemore AIF, Froguel P. Genetics of obesity and the prediction of risk for health Human Molecular Genetics. 15. PMID 16987875 DOI: 10.1093/Hmg/Ddl215 | 0.38 | |||
| 2006 | Das SK, Chu WS, Hale TC, Wang X, Craig RL, Wang H, Shuldiner AR, Froguel P, Deloukas P, McCarthy MI, Zeggini E, Hasstedt SJ, Elbein SC. Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes Diabetes. 55: 2631-2639. PMID 16936214 DOI: 10.2337/Db05-1369 | 0.425 | |||
| 2006 | Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, ... ... Froguel P, et al. Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes. 55: 2541-8. PMID 16936202 DOI: 10.2337/Db06-0088 | 0.424 | |||
| 2006 | Séron K, Corset L, Vasseur F, Boutin P, Gómez-Ambrosi J, Salvador J, Frühbeck G, Froguel P. Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women Biochemical and Biophysical Research Communications. 348: 1232-1238. PMID 16920065 DOI: 10.1016/J.Bbrc.2006.07.068 | 0.356 | |||
| 2006 | Babenko AP, Polak M, Cavé H, Busiah K, Czernichow P, Scharfmann R, Bryan J, Aguilar-Bryan L, Vaxillaire M, Froguel P. Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. The New England Journal of Medicine. 355: 456-66. PMID 16885549 DOI: 10.1056/Nejmoa055068 | 0.365 | |||
| 2006 | Sørensen TIA, Boutin P, Taylor MA, Larsen LH, Verdich C, Petersen L, Holst C, Echwald SM, Dina C, Toubro S, Petersen M, Polak J, Clément K, Martínez JA, Langin D, ... ... Froguel P, et al. Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets Plos Clinical Trials. 1. PMID 16871334 DOI: 10.1371/Journal.Pctr.0010012 | 0.363 | |||
| 2006 | Tsuchiya T, Schwarz PE, Bosque-Plata LD, Geoffrey Hayes M, Dina C, Froguel P, Wayne Towers G, Fischer S, Temelkova-Kurktschiev T, Rietzsch H, Graessler J, Vcelák J, Palyzová D, Selisko T, Bendlová B, et al. Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Molecular Genetics and Metabolism. 89: 174-84. PMID 16837224 DOI: 10.1016/J.Ymgme.2006.05.013 | 0.365 | |||
| 2006 | Cheyssac C, Lecoeur C, Dechaume A, Bibi A, Charpentier G, Balkau B, Marre M, Froguel P, Gibson F, Vaxillaire M. Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population. Bmc Medical Genetics. 7: 44-44. PMID 16677372 DOI: 10.1186/1471-2350-7-44 | 0.479 | |||
| 2006 | Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Tobe K, Nagai R, Kadowaki T. Hepatocyte Nuclear Factor-4α P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population Diabetes. 55: 1260-1264. PMID 16644680 DOI: 10.2337/Db05-0620 | 0.433 | |||
| 2006 | Vaxillaire M, Froguel P. Genetic basis of maturity-onset diabetes of the young. Endocrinology and Metabolism Clinics of North America. 35: 371-384. PMID 16632099 DOI: 10.1016/J.Ecl.2006.02.009 | 0.442 | |||
| 2006 | Vu-Hong T, Durand E, Deghmoun S, Boutin P, Meyre D, Chevenne D, Czernichow P, Froguel P, Levy-Marchal C. The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults. The Journal of Clinical Endocrinology and Metabolism. 91: 2437-2440. PMID 16595598 DOI: 10.1210/Jc.2005-2245 | 0.345 | |||
| 2006 | Cheyssac C, Dina C, Leprêtre F, Vasseur-Delannoy V, Dechaume A, Lobbens S, Balkau B, Ruiz J, Charpentier G, Pattou F, Joly E, Prentki M, Hansen T, Pedersen O, Vaxillaire M, ... Froguel P, et al. EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families. Diabetes. 55: 1171-6. PMID 16567544 DOI: 10.2337/Diabetes.55.04.06.Db05-1298 | 0.445 | |||
| 2006 | Jaziri R, Lobbens S, Aubert R, Péan F, Lahmidi S, Vaxillaire M, Porchay I, Bellili N, Tichet J, Balkau B, Froguel P, Marre M, Fumeron F. The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Diabetes. 55: 1157-1162. PMID 16567542 DOI: 10.2337/Diabetes.55.04.06.Db05-0676 | 0.399 | |||
| 2006 | Meyre D, Froguel P. [ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes]. M S-Medecine Sciences. 22: 308. PMID 16527214 DOI: 10.1051/Medsci/2006223308 | 0.462 | |||
| 2006 | Vaxillaire M, Dechaume A, Vasseur-Delannoy V, Lahmidi S, Vatin V, Leprêtre F, Boutin P, Hercberg S, Charpentier G, Dina C, Froguel P. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes. 55: 856-861. PMID 16505255 DOI: 10.2337/Diabetes.55.03.06.Db05-0665 | 0.467 | |||
| 2006 | Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D, Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, ... ... Froguel P, et al. A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metabolism. 3: 135-40. PMID 16459314 DOI: 10.1016/J.Cmet.2006.01.006 | 0.341 | |||
| 2006 | Bouatia-Naji N, Meyre D, Lobbens S, Séron K, Fumeron F, Balkau B, Heude B, Jouret B, Scherer PE, Dina C, Weill J, Froguel P. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes. 55: 545-50. PMID 16443793 DOI: 10.2337/Diabetes.55.02.06.Db05-0971 | 0.405 | |||
| 2006 | Guérardel A, Tankó LB, Boutin P, Christiansen C, Froguel P. Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women. Osteoporosis International. 17: 156-157. PMID 16228103 DOI: 10.1007/S00198-005-2022-1 | 0.324 | |||
| 2006 | Meyre D, Froguel P. ENPP1, premier exemple d’un déterminant génétique commun à l’obésité et au diabète de type 2 M S-Medecine Sciences. 22: 308-312. DOI: 10.7202/012787Ar | 0.342 | |||
| 2005 | Lacquemant C, Vasseur F, Leprêtre F, Froguel P. [Adipocytokins, obesity and development of type 2 diabetes]. Medecine Sciences : M/S. 21: 10-8. PMID 16598899 | 0.804 | |||
| 2005 | Tankó LB, Siddiq A, Lecoeur C, Larsen PJ, Christiansen C, Walley A, Froguel P. ACDC/Adiponectin and PPAR‐γ Gene Polymorphisms: Implications for Features of Obesity Obesity Research. 13: 2113-2121. PMID 16421345 DOI: 10.1038/Oby.2005.262 | 0.35 | |||
| 2005 | Grasberger H, Vaxillaire M, Pannain S, Beck JC, Mimouni-Bloch A, Vatin V, Vassart G, Froguel P, Refetoff S. Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1 Human Genetics. 118: 348-355. PMID 16189712 DOI: 10.1007/S00439-005-0036-6 | 0.313 | |||
| 2005 | Bell CG, Meyre D, Samson C, Boyle C, Lecoeur C, Tauber M, Jouret B, Jaquet D, Levy-Marchal C, Charles MA, Weill J, Gibson F, Mein CA, Froguel P, Walley AJ. Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity. Diabetes. 54: 3049-55. PMID 16186414 DOI: 10.2337/Diabetes.54.10.3049 | 0.619 | |||
| 2005 | Gibson F, Hercberg S, Froguel P. Common Polymorphisms in the USF1 Gene Are Not Associated With Type 2 Diabetes in French Caucasians Diabetes. 54: 3040-3042. PMID 16186412 DOI: 10.2337/Diabetes.54.10.3040 | 0.435 | |||
| 2005 | Siddiq A, Lepretre F, Hercberg S, Froguel P, Gibson F. A Synonymous Coding Polymorphism in the α2-Heremans-Schmid Glycoprotein Gene Is Associated With Type 2 Diabetes in French Caucasians Diabetes. 54: 2477-2481. PMID 16046317 DOI: 10.2337/Diabetes.54.8.2477 | 0.425 | |||
| 2005 | Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clément K, ... ... Froguel P, et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes Nature Genetics. 37: 863-867. PMID 16025115 DOI: 10.1038/Ng1604 | 0.733 | |||
| 2005 | Boutin P, Froguel P. GAD2: a polygenic contribution to genetic susceptibility for common obesity? Pathologie Biologie. 53: 305-307. PMID 16004939 DOI: 10.1016/J.Patbio.2004.09.008 | 0.366 | |||
| 2005 | Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes Diabetologia. 48: 1307-1314. PMID 15918014 DOI: 10.1007/S00125-005-1806-3 | 0.429 | |||
| 2005 | Vasseur F, Helbecque N, Lobbens S, Vasseur-Delannoy V, Dina C, Clément K, Boutin P, Kadowaki T, Scherer PE, Froguel P. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia. 48: 892-9. PMID 15830179 DOI: 10.1007/S00125-005-1729-Z | 0.359 | |||
| 2005 | Guérardel A, Barat-Houari M, Vasseur F, Dina C, Vatin V, Clément K, Eberlé D, Vasseur-Delannoy V, Bell CG, Galan P, Hercberg S, Helbecque N, Potoczna N, Horber FF, Boutin P, ... Froguel P, et al. Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. Bmc Genetics. 6: 19. PMID 15823203 DOI: 10.1186/1471-2156-6-19 | 0.6 | |||
| 2005 | Ghoussaini M, Meyre D, Lobbens S, Charpentier G, Clément K, Charles MA, Tauber M, Weill J, Froguel P. Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population Bmc Medical Genetics. 6. PMID 15784141 DOI: 10.1186/1471-2350-6-11 | 0.733 | |||
| 2005 | Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, Vaillant E, Benmezroua Y, Durand E, Bakaher N, Delannoy V, Vaxillaire M, Cook T, Dallinga-Thie GM, Jansen H, ... ... Froguel P, et al. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proceedings of the National Academy of Sciences of the United States of America. 102: 4807-12. PMID 15774581 DOI: 10.1073/Pnas.0409177102 | 0.425 | |||
| 2005 | Bell CG, Walley AJ, Froguel P. The genetics of human obesity. Nature Reviews. Genetics. 6: 221-34. PMID 15703762 DOI: 10.1038/Nrg1556 | 0.604 | |||
| 2005 | Meyre D, Boutin P, Tounian A, Deweirder M, Aout M, Jouret B, Heude B, Weill J, Tauber M, Tounian P, Froguel P. Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children The Journal of Clinical Endocrinology and Metabolism. 90: 2384-2390. PMID 15671113 DOI: 10.1210/Jc.2004-1468 | 0.434 | |||
| 2005 | Vozarova de Courten B, Hanson RL, Funahashi T, Lindsay RS, Matsuzawa Y, Tanaka S, Thameem F, Gruber JD, Froguel P, Wolford JK. Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians. Diabetes. 54: 284-9. PMID 15616040 DOI: 10.2337/Diabetes.54.1.284 | 0.477 | |||
| 2004 | Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, ... ... Froguel P, et al. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 47: A1-A464. PMID 27770180 DOI: 10.1007/Bf03375463 | 0.356 | |||
| 2004 | Leprêtre F, Linton KJ, Lacquemant C, Vatin V, Samson C, Dina C, Chikri M, Ali S, Scherer P, Séron K, Vasseur F, Aitman T, Froguel P. Genetic study of the CD36 gene in a French diabetic population. Diabetes & Metabolism. 30: 459-63. PMID 15671915 DOI: 10.1016/S1262-3636(07)70143-X | 0.802 | |||
| 2004 | Gibson F, Froguel P. Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians. Diabetes. 53: 2977-2983. PMID 15504979 DOI: 10.2337/Diabetes.53.11.2977 | 0.428 | |||
| 2004 | Allotey RA, Mohan V, McDermott MF, Deepa R, Premalatha G, Hassan Z, Cassell PG, North BV, Vaxillaire M, Mein CA, Swan DC, O'Grady E, Ramachandran A, Snehalatha C, Sinnot PJ, ... ... Froguel P, et al. The EIF2AK3 gene region and type I diabetes in subjects from South India. Genes and Immunity. 5: 648-52. PMID 15483661 DOI: 10.1038/Sj.Gene.6364139 | 0.453 | |||
| 2004 | Vaxillaire M, Populaire C, Busiah K, Cavé H, Gloyn AL, Hattersley AT, Czernichow P, Froguel P, Polak M. Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients. Diabetes. 53: 2719-22. PMID 15448107 DOI: 10.2337/Diabetes.53.10.2719 | 0.808 | |||
| 2004 | Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P. Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians Diabetes. 53: 2483-2486. PMID 15331564 DOI: 10.2337/Diabetes.53.9.2483 | 0.402 | |||
| 2004 | Eberlé D, Clément K, Meyre D, Sahbatou M, Vaxillaire M, Le Gall A, Ferré P, Basdevant A, Froguel P, Foufelle F. SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. Diabetes. 53: 2153-7. PMID 15277400 DOI: 10.2337/Diabetes.53.8.2153 | 0.454 | |||
| 2004 | Kipfer-Coudreau S, Eberlé D, Sahbatou M, Bonhomme A, Guy-Grand B, Froguel P, Galan P, Basdevant A, Clément K. Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects Diabetologia. 47: 1278-1284. PMID 15235769 DOI: 10.1007/S00125-004-1432-5 | 0.389 | |||
| 2004 | Leprêtre F, Vasseur F, Vaxillaire M, Scherer PE, Ali S, Linton K, Aitman T, Froguel P. A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Human Mutation. 24: 104. PMID 15221799 DOI: 10.1002/Humu.9256 | 0.39 | |||
| 2004 | Bell CG, Benzinou M, Siddiq A, Lecoeur C, Dina C, Lemainque A, Clément K, Basdevant A, Guy-Grand B, Mein CA, Meyre D, Froguel P. Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q. Diabetes. 53: 1857-65. PMID 15220211 DOI: 10.2337/Diabetes.53.7.1857 | 0.58 | |||
| 2004 | Lacquemant C, Froguel P, Lobbens S, Izzo P, Dina C, Ruiz J. The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus. Diabetic Medicine : a Journal of the British Diabetic Association. 21: 776-81. PMID 15209773 DOI: 10.1111/J.1464-5491.2004.01224.X | 0.81 | |||
| 2004 | Weill J, Vanderbecken S, Froguel P. Understanding the rising incidence of type 2 diabetes in adolescence Archives of Disease in Childhood. 89: 502-504. PMID 15155389 DOI: 10.1136/Adc.2003.028548 | 0.393 | |||
| 2004 | Fumeron F, Aubert R, Siddiq A, Betoulle D, Péan F, Hadjadj S, Tichet J, Wilpart E, Chesnier M, Balkau B, Froguel P, Marre M. Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes. 53: 1150-1157. PMID 15047634 DOI: 10.2337/Diabetes.53.4.1150 | 0.45 | |||
| 2004 | Heude B, Dubois S, Charles MA, Deweirder M, Dina C, Borys JM, Ducimetière P, Froguel P. VNTR polymorphism of the insulin gene and childhood overweight in a general population Obesity Research. 12: 499-504. PMID 15044667 DOI: 10.1038/Oby.2004.56 | 0.704 | |||
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