| Year |
Citation |
Score |
| 2024 |
Caruso JA, Tlsty TD. An adaptive Epithelial-Mesenchymal Transition Program Enables Basal Epithelial Cells to Bypass Stress-Induced Stasis and Contributes to Metaplastic Breast Cancer Progenitor State. Research Square. PMID 39399685 DOI: 10.21203/rs.3.rs-4980285/v1 |
0.416 |
|
| 2024 |
Faupel-Badger J, Kohaar I, Bahl M, Chan AT, Campbell JD, Ding L, De Marzo AM, Maitra A, Merrick DT, Hawk ET, Wistuba II, Ghobrial IM, Lippman SM, Lu KH, Lawler M, ... ... Tlsty TD, et al. Defining precancer: a grand challenge for the cancer community. Nature Reviews. Cancer. PMID 39354069 DOI: 10.1038/s41568-024-00744-0 |
0.312 |
|
| 2023 |
Strasser MK, Gibbs DL, Gascard P, Bons J, Hickey JW, Schürch CM, Tan Y, Black S, Chu P, Ozkan A, Basisty N, Sangwan V, Rose J, Shah S, Camilleri-Broet S, ... ... Tlsty TD, et al. Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis. Biorxiv : the Preprint Server For Biology. PMID 37333362 DOI: 10.1101/2023.06.08.544265 |
0.315 |
|
| 2022 |
Murrow LM, Weber RJ, Caruso JA, McGinnis CS, Phong K, Gascard P, Rabadam G, Borowsky AD, Desai TA, Thomson M, Tlsty T, Gartner ZJ. Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution. Cell Systems. PMID 35863345 DOI: 10.1016/j.cels.2022.06.005 |
0.305 |
|
| 2020 |
Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, ... ... Tlsty TD, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews. Cancer. PMID 31980749 DOI: 10.1038/S41568-019-0238-1 |
0.37 |
|
| 2019 |
Yin J, Gascard P, Singh M, Tlsty T, Tjoe J. Abstract P5-18-04: HER2 overexpression in ductal carcinoma in situ: A biomarker for risk stratification and therapeutic implication Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P5-18-04 |
0.39 |
|
| 2017 |
Fuhrmann A, Banisadr A, Beri P, Tlsty TD, Engler AJ. Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. Biophysical Journal. 112: 736-745. PMID 28256233 DOI: 10.1016/J.Bpj.2016.12.038 |
0.434 |
|
| 2016 |
Pan D, Roy S, Gascard P, Zhao J, Chen-Tanyolac C, Tlsty TD. SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73. Cellular Signalling. PMID 27705752 DOI: 10.1016/J.Cellsig.2016.09.008 |
0.374 |
|
| 2016 |
Gascard P, Tlsty TD. Carcinoma-associated fibroblasts: orchestrating the composition of malignancy. Genes & Development. 30: 1002-19. PMID 27151975 DOI: 10.1101/Gad.279737.116 |
0.419 |
|
| 2016 |
Molinaro AM, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K. Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. Breast Cancer Research and Treatment. PMID 27146587 DOI: 10.1007/S10549-016-3814-Z |
0.317 |
|
| 2015 |
Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL. Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Scientific Reports. 5: 15153. PMID 26472542 DOI: 10.1038/Srep15153 |
0.317 |
|
| 2015 |
Drake CR, Estévez-Salmerón L, Gascard P, Shen Y, Tlsty TD, Jones EF. Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. Organic & Biomolecular Chemistry. 13: 11078-86. PMID 26400105 DOI: 10.1039/C5Ob01805F |
0.315 |
|
| 2015 |
Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, ... ... Tlsty TD, et al. Integrative analysis of 111 reference human epigenomes. Nature. 518: 317-30. PMID 25693563 DOI: 10.1038/Nature14248 |
0.43 |
|
| 2015 |
Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, et al. Intermediate DNA methylation is a conserved signature of genome regulation. Nature Communications. 6: 6363. PMID 25691127 DOI: 10.1038/Ncomms7363 |
0.383 |
|
| 2015 |
Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, ... ... Tlsty TD, et al. Epigenetic and transcriptional determinants of the human breast. Nature Communications. 6: 6351. PMID 25690954 DOI: 10.1038/Ncomms7351 |
0.49 |
|
| 2015 |
Tjoe JA, Gascard P, Zhao J, Neitzel GF, Singh M, Last B, Marx J, Tlsty T, Kansra S. Does the Expression of Ki-67, p16 and COX-2 at Initial Diagnosis of Breast Atypia or Usual Ductal Hyperplasia Predict a Second Clinically Significant Event? Journal of Patient-Centered Research and Reviews. 2: 215-216. DOI: 10.17294/2330-0698.1246 |
0.359 |
|
| 2014 |
Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB. Regulatory network decoded from epigenomes of surface ectoderm-derived cell types. Nature Communications. 5: 5442. PMID 25421844 DOI: 10.1038/Ncomms6442 |
0.461 |
|
| 2014 |
DeFilippis RA, Fordyce C, Patten K, Chang H, Zhao J, Fontenay GV, Kerlikowske K, Parvin B, Tlsty TD. Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. Cancer Research. 74: 5032-44. PMID 25172842 DOI: 10.1158/0008-5472.Can-13-3390 |
0.437 |
|
| 2014 |
Wu A, Liao D, Tlsty TD, Sturm JC, Austin RH. Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment. Interface Focus. 4: 20140028. PMID 25097749 DOI: 10.1098/Rsfs.2014.0028 |
0.375 |
|
| 2014 |
Mori M, Krings G, Chan L, Wolf D, Chen Y, Kerlikowske K, Tlsty TD, Coppe J, Matsuda N, Suzuki K, Nakamura S, van't Veer L. Predictive biomarkers of invasive carcinoma on excision in patients with a diagnosis of ductal carcinoma in situ of the breast by needle biopsy. Journal of Clinical Oncology. 32: e12029-e12029. DOI: 10.1200/Jco.2014.32.15_Suppl.E12029 |
0.305 |
|
| 2013 |
Wu A, Loutherback K, Lambert G, Estévez-Salmerón L, Tlsty TD, Austin RH, Sturm JC. Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. 110: 16103-8. PMID 24046372 DOI: 10.1073/Pnas.1314385110 |
0.388 |
|
| 2013 |
Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, ... ... Tlsty TD, et al. Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Research. 23: 1522-40. PMID 23804400 DOI: 10.1101/Gr.156539.113 |
0.365 |
|
| 2013 |
Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, et al. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nature Genetics. 45: 836-41. PMID 23708189 DOI: 10.1038/Ng.2649 |
0.366 |
|
| 2013 |
López-DÃaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM. Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response. Molecular Cell. 50: 552-64. PMID 23706820 DOI: 10.1016/J.Molcel.2013.04.029 |
0.342 |
|
| 2013 |
Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Tlsty TD, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/Srep01449 |
0.389 |
|
| 2013 |
Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD. Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proceedings of the National Academy of Sciences of the United States of America. 110: 4598-603. PMID 23487770 DOI: 10.1073/Pnas.1218682110 |
0.491 |
|
| 2013 |
Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, Tlsty TD. Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia (New York, N.Y.). 15: 249-62. PMID 23479504 DOI: 10.1593/Neo.121950 |
0.452 |
|
| 2013 |
Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD. Abstract LB-273: The tumor suppressor p16INK4a regulates extensive plasticity in rare somatic cells found in adult human tissue. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-273 |
0.526 |
|
| 2013 |
Mori M, Krings G, Chan L, Chen Y, Kerlikowske K, Tlsty T, Matsuda N, Suzuki K, Veer Lv. Abstract P5-16-04: Predictive biomarkers for invasion on final pathology in patients with preoperative diagnosis of ductal carcinoma in situ of the breast by needle biopsy Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-P5-16-04 |
0.338 |
|
| 2012 |
Fordyce CA, Patten KT, Fessenden TB, DeFilippis R, Hwang ES, Zhao J, Tlsty TD. Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. Breast Cancer Research : Bcr. 14: R155. PMID 23216814 DOI: 10.1186/Bcr3368 |
0.447 |
|
| 2012 |
Liao D, Estévez-Salmerón L, Tlsty TD. Conceptualizing a tool to optimize therapy based on dynamic heterogeneity. Physical Biology. 9: 065005. PMID 23197078 DOI: 10.1088/1478-3975/9/6/065005 |
0.313 |
|
| 2012 |
DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, Berman HK, Gauthier ML, Zhao J, Hu D, Marx JJ, Tjoe JA, Ziv E, Febbraio M, Kerlikowske K, ... ... Tlsty TD, et al. CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discovery. 2: 826-39. PMID 22777768 DOI: 10.1158/2159-8290.Cd-12-0107 |
0.354 |
|
| 2012 |
Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, ... ... Tlsty T, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature. 486: 395-9. PMID 22495314 DOI: 10.1038/Nature10933 |
0.374 |
|
| 2011 |
Radisky DC, Santisteban M, Berman HK, Gauthier ML, Frost MH, Reynolds CA, Vierkant RA, Pankratz VS, Visscher DW, Tlsty TD, Hartmann LC. p16 INK4a expression and breast cancer risk in women with atypical hyperplasia Cancer Prevention Research. 4: 1953-1960. PMID 21920875 DOI: 10.1158/1940-6207.Capr-11-0282 |
0.437 |
|
| 2011 |
Tlsty TD. Tissue states provide novel insights into attributes that drive metastasis. Cancer Cell. 20: 285-6. PMID 21907919 DOI: 10.1016/J.Ccr.2011.08.018 |
0.408 |
|
| 2011 |
Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH. An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nature Reviews. Cancer. 11: 375-82. PMID 21508974 DOI: 10.1038/Nrc3039 |
0.313 |
|
| 2011 |
Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. Journal of Surgical Oncology. 103: 468-74. PMID 21480238 DOI: 10.1002/Jso.21709 |
0.4 |
|
| 2011 |
Tlsty TD. A twist of cell fate. Cell Stem Cell. 8: 126-7. PMID 21295267 DOI: 10.1016/J.Stem.2011.01.004 |
0.458 |
|
| 2011 |
Duewer F, Kerlikowske K, Tlsty T, Fan B, Parvin B, Ma L, Shepherd J. P5-08-02: Mammographic Breast Texture Predicts Benign Biopsy Results and Composition. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P5-08-02 |
0.342 |
|
| 2010 |
Kerlikowske K, Molinaro AM, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD. Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. Journal of the National Cancer Institute. 102: 627-37. PMID 20427430 DOI: 10.1093/Jnci/Djq101 |
0.393 |
|
| 2010 |
Berman HK, Gauthier ML, Tlsty TD. Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications. Cancer Prevention Research (Philadelphia, Pa.). 3: 579-87. PMID 20424132 DOI: 10.1158/1940-6207.Capr-10-0073 |
0.354 |
|
| 2010 |
McDermott KM, Liu BY, Tlsty TD, Pazour GJ. Primary cilia regulate branching morphogenesis during mammary gland development. Current Biology : Cb. 20: 731-7. PMID 20381354 DOI: 10.1016/J.Cub.2010.02.048 |
0.36 |
|
| 2010 |
Blackburn EH, Tlsty TD, Lippman SM. Unprecedented opportunities and promise for cancer prevention research. Cancer Prevention Research (Philadelphia, Pa.). 3: 394-402. PMID 20354163 DOI: 10.1158/1940-6207.Capr-10-0051 |
0.377 |
|
| 2010 |
Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T. DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. Cancer Prevention Research (Philadelphia, Pa.). 3: 190-201. PMID 20028875 DOI: 10.1158/1940-6207.Capr-09-0229 |
0.692 |
|
| 2009 |
Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC, Turashvili G, Aparicio S, Gauthier ML, Fordyce CA, McDermott KM, Tlsty TD. Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy. Breast Cancer Research : Bcr. 11: R87. PMID 19995452 DOI: 10.1186/Bcr2457 |
0.806 |
|
| 2009 |
Tlsty TD. Abstract IA-14: Molecular alterations that predict premalignancy in breast cancer Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-Ia-14 |
0.393 |
|
| 2008 |
Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proceedings of the National Academy of Sciences of the United States of America. 105: 14867-72. PMID 18806226 DOI: 10.1073/Pnas.0807146105 |
0.799 |
|
| 2008 |
Tlsty T. Cancer: whispering sweet somethings. Nature. 453: 604-5. PMID 18509432 DOI: 10.1038/453604A |
0.347 |
|
| 2008 |
Dumont N, Crawford YG, Reynolds PA, Wilson MB, Sigaroudinia M, Gauthier ML, Fordyce CA, Tlsty TD. Abstract LB-334: Signals from the microenvironment induce a malignant program accompanied by de novo epigenetic remodeling Cancer Research. 68. DOI: 10.1158/1538-7445.Am2008-Lb-334 |
0.814 |
|
| 2007 |
Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, ... ... Tlsty TD, et al. Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 6834-41. PMID 18006786 DOI: 10.1158/1078-0432.Ccr-07-0407 |
0.551 |
|
| 2007 |
Gauthier ML, Berman HK, Miller C, Kozakeiwicz K, Chew K, Moore D, Rabban J, Chen YY, Kerlikowske K, Tlsty TD. Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors. Cancer Cell. 12: 479-91. PMID 17996651 DOI: 10.1016/J.Ccr.2007.10.017 |
0.365 |
|
| 2007 |
Garbe JC, Holst CR, Bassett E, Tlsty T, Stampfer MR. Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis. Cell Cycle (Georgetown, Tex.). 6: 1927-36. PMID 17671422 DOI: 10.4161/Cc.6.15.4519 |
0.785 |
|
| 2007 |
Tlsty TD. Luminal cells GATA have it. Nature Cell Biology. 9: 135-6. PMID 17268476 DOI: 10.1038/Ncb0207-135 |
0.482 |
|
| 2006 |
Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annual Review of Pathology. 1: 119-50. PMID 18039110 DOI: 10.1146/Annurev.Pathol.1.110304.100224 |
0.496 |
|
| 2006 |
Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD. p16INK4a modulates p53 in primary human mammary epithelial cells. Cancer Research. 66: 10325-31. PMID 17079452 DOI: 10.1158/0008-5472.Can-06-1594 |
0.779 |
|
| 2006 |
Grant MR, Mostov KE, Tlsty TD, Hunt CA. Simulating properties of in vitro epithelial cell morphogenesis. Plos Computational Biology. 2: e129. PMID 17029556 DOI: 10.1371/Journal.Pcbi.0020129 |
0.388 |
|
| 2006 |
Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. The Journal of Biological Chemistry. 281: 24790-802. PMID 16766534 DOI: 10.1074/Jbc.M604175200 |
0.808 |
|
| 2006 |
McDermott KM, Zhang J, Holst CR, Kozakiewicz BK, Singla V, Tlsty TD. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. Plos Biology. 4: e51. PMID 16464125 DOI: 10.1371/Journal.Pbio.0040051 |
0.804 |
|
| 2005 |
Berman H, Zhang J, Crawford YG, Gauthier ML, Fordyce CA, McDermott KM, Sigaroudinia M, Kozakiewicz K, Tlsty TD. Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis. Cold Spring Harbor Symposia On Quantitative Biology. 70: 317-27. PMID 16869768 DOI: 10.1101/Sqb.2005.70.051 |
0.822 |
|
| 2005 |
Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, et al. Benign breast disease and the risk of breast cancer. The New England Journal of Medicine. 353: 229-37. PMID 16034008 DOI: 10.1056/Nejmoa044383 |
0.315 |
|
| 2005 |
Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Cancer Research. 65: 1792-9. PMID 15753376 DOI: 10.1158/0008-5472.Can-04-3507 |
0.711 |
|
| 2005 |
Dumont N, Crawford Y, Reynolds P, Tlsty T. Cooperation between extracellular signaling and intracellular Ras activation leads to immortalization and epithelial-to-mesenchymal transition of variant human mammary epithelial cells Breast Cancer Research. 7: 1-1. DOI: 10.1186/Bcr1126 |
0.813 |
|
| 2005 |
Tlsty T. Genetic and epigenetic changes in early carcinogenesis Breast Cancer Research. 7: 1-1. DOI: 10.1186/Bcr1057 |
0.532 |
|
| 2004 |
Tlsty TD, Crawford YG, Holst CR, Fordyce CA, Zhang J, McDermott K, Kozakiewicz K, Gauthier ML. Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis. Journal of Mammary Gland Biology and Neoplasia. 9: 263-74. PMID 15557799 DOI: 10.1023/B:Jomg.0000048773.95897.5F |
0.788 |
|
| 2004 |
Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell. 5: 263-73. PMID 15050918 DOI: 10.1016/S1535-6108(04)00023-6 |
0.811 |
|
| 2003 |
Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Research. 63: 1596-601. PMID 12670910 |
0.809 |
|
| 2002 |
Tlsty TD. Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer. Cancer Cell. 2: 2-4. PMID 12150817 DOI: 10.1016/S1535-6108(02)00088-0 |
0.388 |
|
| 2002 |
Venetsanakos E, Mirza A, Fanton C, Romanov SR, Tlsty T, McMahon M. Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells. Experimental Cell Research. 273: 21-33. PMID 11795943 DOI: 10.1006/Excr.2001.5424 |
0.439 |
|
| 2001 |
Tlsty TD, Romanov SR, Kozakiewicz BK, Holst CR, Haupt LM, Crawford YG. Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence. Journal of Mammary Gland Biology and Neoplasia. 6: 235-43. PMID 11501583 DOI: 10.1023/A:1011369026168 |
0.779 |
|
| 2001 |
Stoeber K, Tlsty TD, Happerfield L, Thomas GA, Romanov S, Bobrow L, Williams ED, Williams GH. DNA replication licensing and human cell proliferation. Journal of Cell Science. 114: 2027-41. PMID 11493639 |
0.393 |
|
| 2001 |
Tlsty TD. Stromal cells can contribute oncogenic signals Seminars in Cancer Biology. 11: 97-104. PMID 11322829 DOI: 10.1006/Scbi.2000.0361 |
0.477 |
|
| 2001 |
Romanov SR, Kozakiewicz BK, Holst CR, Stampfer MR, Haupt LM, Tlsty TD. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature. 409: 633-7. PMID 11214324 DOI: 10.1038/35054579 |
0.792 |
|
| 2001 |
Tlsty TD, Hein PW. Know thy neighbor: stromal cells can contribute oncogenic signals. Current Opinion in Genetics & Development. 11: 54-9. PMID 11163151 DOI: 10.1016/S0959-437X(00)00156-8 |
0.484 |
|
| 2001 |
Tlsty TD. Searching for targets: The power of somatic cell genetics Genome Research. 11: 187-188. PMID 11157780 DOI: 10.1101/Gr.177101 |
0.385 |
|
| 2000 |
Felsher DW, Zetterberg A, Zhu J, Tlsty T, Bishop JM. Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 97: 10544-8. PMID 10962037 DOI: 10.1073/Pnas.190327097 |
0.453 |
|
| 1999 |
Meyer KM, Hess SM, Tlsty TD, Leadon SA. Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light. Oncogene. 18: 5795-805. PMID 10523860 DOI: 10.1038/Sj.Onc.1202977 |
0.422 |
|
| 1999 |
Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium Cancer Research. 59: 5002-5011. PMID 10519415 DOI: 10.1186/Bcr138 |
0.367 |
|
| 1999 |
Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nature Genetics. 21: 111-4. PMID 9916802 DOI: 10.1038/5056 |
0.47 |
|
| 1999 |
Olumi AF, Minasi P, Tlsty TD. Carcinoma-Associated Fibroblasts Promote Invasion Of Prostatic Epithelial Cells The Journal of Urology. 58. DOI: 10.1097/00005392-199904010-00233 |
0.329 |
|
| 1998 |
Tlsty TD. Cell-adhesion-dependent influences on genomic instability and carcinogenesis Current Opinion in Cell Biology. 10: 647-653. PMID 9818176 DOI: 10.1016/S0955-0674(98)80041-0 |
0.464 |
|
| 1998 |
Olumi AF, Dazin P, Tlsty TD. A novel coculture technique demonstrates that normal human prostatic fibroblasts contribute to tumor formation of LNCaP cells by retarding cell death Cancer Research. 58: 4525-4530. PMID 9788594 |
0.303 |
|
| 1998 |
Gonzales AJ, Christensen JG, Preston RJ, Goldsworthy TL, Tlsty TD, Fox TR. Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital Carcinogenesis. 19: 1173-1183. PMID 9683175 DOI: 10.1093/Carcin/19.7.1173 |
0.409 |
|
| 1998 |
Hayward SW, Grossfeld GD, Tlsty TD, Cunha GR. Genetic and epigenetic influences in prostatic carcinogenesis (review) International Journal of Oncology. 13: 35-47. PMID 9625801 DOI: 10.3892/Ijo.13.1.35 |
0.318 |
|
| 1998 |
Gualberto A, Aldape K, Kozakiewicz K, Tlsty TD. An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control Proceedings of the National Academy of Sciences of the United States of America. 95: 5166-5171. PMID 9560247 DOI: 10.1073/Pnas.95.9.5166 |
0.416 |
|
| 1998 |
Grossfeld GD, Hayward SW, Tlsty TD, Cunha GR. The role of stroma in prostatic carcinogenesis Endocrine-Related Cancer. 5: 253-270. DOI: 10.1677/Erc.0.0050253 |
0.354 |
|
| 1997 |
Hall IJ, Gioeli D, Weissman BE, Tlsty TD. Identification of additional complementation groups that regulate genomic instability Genes Chromosomes and Cancer. 20: 103-112. PMID 9331561 DOI: 10.1002/(Sici)1098-2264(199710)20:2<103::Aid-Gcc1>3.0.Co;2-7 |
0.419 |
|
| 1997 |
Nigro JM, Aldape KD, Hess SM, Tlsty TD. Cellular adhesion regulates p53 protein levels in primary human keratinocytes. Cancer Research. 57: 3635-9. PMID 9288761 |
0.368 |
|
| 1997 |
Tlsty TD. Genomic instability and its role in neoplasia Current Topics in Microbiology and Immunology. 221: 37-46. PMID 8979439 DOI: 10.1007/978-3-642-60505-5_4 |
0.432 |
|
| 1996 |
Xiong Y, Kuppuswamy D, Li Y, Livanos EM, Hixon M, White A, Beach D, Tlsty TD. Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation. Journal of Virology. 70: 999-1008. PMID 8551641 DOI: 10.1128/Jvi.70.2.999-1008.1996 |
0.418 |
|
| 1996 |
Tlsty T, Briot A, Poulose B. Analysis of cell cycle checkpoint status in mammalian cells. Methods in Enzymology. 254: 125-33. PMID 8531681 DOI: 10.1016/0076-6879(95)54010-5 |
0.407 |
|
| 1996 |
Tlsty TD. Extended abstract: Abrogation of cell cycle checkpoint control in preneoplastic cells Radiation Oncology Investigations. 3: 320-322. DOI: 10.1002/Roi.2970030613 |
0.405 |
|
| 1995 |
Tlsty TD, Briot A, Gualberto A, Hall I, Hess S, Hixon M, Kuppuswamy D, Romanov S, Sage M, White A. Genomic instability and cancer. Mutation Research. 337: 1-7. PMID 7596354 DOI: 10.1016/0921-8777(95)00016-D |
0.315 |
|
| 1995 |
Tlsty TD. Abrogation of cell cycle checkpoint control in preneoplastic cells Cancer Genetics and Cytogenetics. 84: 137. DOI: 10.1016/0165-4608(96)85241-1 |
0.389 |
|
| 1995 |
Tlsty TD. Cell cycle control and genomic instability Cancer and Metastasis Reviews. 14: 1-2. DOI: 10.1007/Bf00690206 |
0.355 |
|
| 1994 |
White AE, Livanos EM, Tlsty TD. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes & Development. 8: 666-77. PMID 7926757 DOI: 10.1101/Gad.8.6.666 |
0.462 |
|
| 1994 |
Forrester K, Kispert J, Sanchez JH, Gerwin BI, Tlsty TD, Harris CC. Clonal variation of tumorigenic potential in v-Ha-ras-transformed human bronchial epithelial cells: relationship to ras oncogene expression and CAD gene amplification. Molecular Carcinogenesis. 11: 34-41. PMID 7916988 DOI: 10.1002/Mc.2940110107 |
0.378 |
|
| 1994 |
Tlsty TD, White A, Livanos E, Sage M, Roelofs H, Briot A, Poulose B. Genomic integrity and the genetics of cancer. Cold Spring Harbor Symposia On Quantitative Biology. 59: 265-75. PMID 7587078 DOI: 10.1101/Sqb.1994.059.01.031 |
0.32 |
|
| 1993 |
Tlsty TD. Genetic regulation of genomic fluidity in normal and neoplastic cells Cancer Genetics and Cytogenetics. 66: 149. DOI: 10.1016/0165-4608(93)90281-P |
0.398 |
|
| 1992 |
Tlsty TD, White A, Sanchez J. Suppression of gene amplification in human cell hybrids Science. 255: 1425-1427. PMID 1542791 DOI: 10.1126/Science.1542791 |
0.398 |
|
| 1992 |
Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell. 70: 923-35. PMID 1356076 DOI: 10.1016/0092-8674(92)90243-6 |
0.464 |
|
| 1990 |
Tlsty TD, Adams P. Replication of the dihydrofolate reductase genes on double minute chromosomes in a murine cell line Experimental Cell Research. 188: 164-168. PMID 2328775 DOI: 10.1016/0014-4827(90)90293-J |
0.371 |
|
| 1990 |
Tlsty TD. Normal diploid human and rodent cells lack a detectable frequency of gene amplification Proceedings of the National Academy of Sciences of the United States of America. 87: 3132-3136. PMID 2326271 DOI: 10.1073/Pnas.87.8.3132 |
0.468 |
|
| 1989 |
Tlsty TD, Margolin BH, Lum K. Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis. Proceedings of the National Academy of Sciences of the United States of America. 86: 9441-5. PMID 2687881 DOI: 10.1073/Pnas.86.23.9441 |
0.433 |
|
| 1984 |
Tlsty TD, Brown PC, Schimke RT. UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells. Molecular and Cellular Biology. 4: 1050-6. PMID 6738530 DOI: 10.1128/Mcb.4.6.1050 |
0.356 |
|
| 1984 |
Tlsty TD, Albertini AM, Miller JH. Gene amplification in the lac region of E. coli Cell. 37: 217-224. PMID 6327052 DOI: 10.1016/0092-8674(84)90317-9 |
0.302 |
|
| 1983 |
Brown PC, Tlsty TD, Schimke RT. Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Molecular and Cellular Biology. 3: 1097-107. PMID 6877240 DOI: 10.1128/Mcb.3.6.1097 |
0.358 |
|
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