Mariann Bienz, PhD - Publications

Affiliations: 
MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom 
Area:
Wnt signalling
Website:
http://www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/m-bienz

85 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wang H, Bienz M, Yan XX, Xu W. Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome. Nature Communications. 14: 3702. PMID 37349336 DOI: 10.1038/s41467-023-39439-9  0.411
2022 Mieszczanek J, Strutt H, Rutherford TJ, Strutt D, Bienz M, Gammons MV. Selective function of the PDZ domain of Dishevelled in noncanonical Wnt signalling. Journal of Cell Science. PMID 35542970 DOI: 10.1242/jcs.259547  0.335
2021 Beitia GJ, Rutherford TJ, Freund SMV, Pelham HR, Bienz M, Gammons MV. Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34155117 DOI: 10.1073/pnas.2103258118  0.363
2020 Gammons MV, Renko M, Flack JE, Mieszczanek J, Bienz M. Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin. Elife. 9. PMID 33025907 DOI: 10.7554/eLife.59879  0.304
2020 Kan W, Enos MD, Korkmazhan E, Muennich S, Chen DH, Gammons MV, Vasishtha M, Bienz M, Dunn AR, Skiniotis G, Weis WI. Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction. Elife. 9. PMID 32297861 DOI: 10.7554/Elife.55015  0.517
2019 Yamanishi K, Fiedler M, Terawaki SI, Higuchi Y, Bienz M, Shibata N. A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to β-catenin. Science Signaling. 12. PMID 31822591 DOI: 10.1126/scisignal.aaw5505  0.417
2019 Renko M, Fiedler M, Rutherford TJ, Schaefer JV, Plückthun A, Bienz M. Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570581 DOI: 10.1073/Pnas.1912705116  0.312
2019 Mieszczanek J, van Tienen LM, Ibrahim AEK, Winton DJ, Bienz M. Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models. Nature Communications. 10: 724. PMID 30760710 DOI: 10.1038/S41467-018-08164-Z  0.731
2017 Gammons M, Bienz M. Multiprotein complexes governing Wnt signal transduction. Current Opinion in Cell Biology. 51: 42-49. PMID 29153704 DOI: 10.1016/J.Ceb.2017.10.008  0.521
2017 Flack JE, Mieszczanek J, Novcic N, Bienz M. Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Molecular Cell. PMID 28689657 DOI: 10.1016/J.Molcel.2017.06.009  0.562
2017 van Tienen LM, Mieszczanek J, Fiedler M, Rutherford T, Bienz M. Correction: Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. Elife. 6. PMID 28358670 DOI: 10.7554/eLife.27150  0.711
2017 van Tienen LM, Mieszczanek J, Fiedler M, Rutherford TJ, Bienz M. Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. Elife. 6. PMID 28296634 DOI: 10.7554/Elife.20882  0.742
2016 Gammons MV, Rutherford TJ, Steinhart Z, Angers S, Bienz M. Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay. Journal of Cell Science. 129: 3892-3902. PMID 27744318 DOI: 10.1242/Jcs.195685  0.528
2016 Gammons MV, Renko M, Johnson CM, Rutherford TJ, Bienz M. Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled. Molecular Cell. PMID 27692984 DOI: 10.1016/J.Molcel.2016.08.026  0.493
2016 Teo AED, Garg S, Haris Shaikh L, Zhou J, Karet Frankl FE, Gurnell M, Happerfield L, Marker A, Bienz M, Azizan EAB, Brown MJ. Effect of somatic CTNNB1 mutations on adrenocortical cell de-differentiation in adenoma presenting in early pregnancy or menopause Annales D'Endocrinologie. 77: 161-162. DOI: 10.1016/J.Ando.2016.04.022  0.374
2015 Mund T, Graeb M, Mieszczanek J, Gammons M, Pelham HR, Bienz M. Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled. Open Biology. 5. PMID 26701932 DOI: 10.1098/Rsob.150185  0.518
2015 Teo AE, Garg S, Haris Shaikh L, Zhou J, Karet Frankl FE, Gurnell M, Happerfield L, Marker A, Bienz M, Azizan EA, Brown MJ. Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations. The New England Journal of Medicine. PMID 26397949 DOI: 10.1056/Nejmoa1504869  0.329
2015 Fiedler M, Graeb M, Mieszczanek J, Rutherford TJ, Johnson CM, Bienz M. An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP. Elife. 4. PMID 26312500 DOI: 10.7554/Elife.09073  0.531
2015 Madrzak J, Fiedler M, Johnson CM, Ewan R, Knebel A, Bienz M, Chin JW. Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization. Nature Communications. 6: 6718. PMID 25907794 DOI: 10.1038/Ncomms7718  0.387
2014 Silva AL, Dawson SN, Arends MJ, Guttula K, Hall N, Cameron EA, Huang TH, Brenton JD, Tavaré S, Bienz M, Ibrahim AE. Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists. Bmc Cancer. 14: 891. PMID 25432628 DOI: 10.1186/1471-2407-14-891  0.413
2014 Miller TC, Rutherford TJ, Birchall K, Chugh J, Fiedler M, Bienz M. Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger. Acs Chemical Biology. 9: 2864-74. PMID 25323450 DOI: 10.1021/Cb500585S  0.397
2014 Bienz M. Signalosome assembly by domains undergoing dynamic head-to-tail polymerization. Trends in Biochemical Sciences. 39: 487-95. PMID 25239056 DOI: 10.1016/J.Tibs.2014.08.006  0.373
2014 de la Roche M, Ibrahim AE, Mieszczanek J, Bienz M. LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer Research. 74: 1495-505. PMID 24419084 DOI: 10.1158/0008-5472.Can-13-2682  0.479
2013 Miller TC, Mieszczanek J, Sánchez-Barrena MJ, Rutherford TJ, Fiedler M, Bienz M. Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2. Structure (London, England : 1993). 21: 2208-20. PMID 24183574 DOI: 10.1016/J.Str.2013.09.013  0.446
2012 Bienz M, He X. Biochemistry. A lipid linchpin for Wnt-Fz docking. Science (New York, N.Y.). 337: 44-5. PMID 22653728 DOI: 10.1126/Science.1224468  0.41
2012 de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM, Bienz M. An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid. Nature Communications. 3: 680. PMID 22353711 DOI: 10.1038/Ncomms1680  0.47
2012 Licchesi JD, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, El Oualid F, Chin JW, Ovaa H, Bienz M, Komander D. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. Nature Structural & Molecular Biology. 19: 62-71. PMID 22157957 DOI: 10.1038/Nsmb.2169  0.32
2011 Mendoza-Topaz C, Mieszczanek J, Bienz M. The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. Open Biology. 1: 110013. PMID 22645652 DOI: 10.1098/Rsob.110013  0.491
2011 Metcalfe C, Bienz M. Inhibition of GSK3 by Wnt signalling--two contrasting models. Journal of Cell Science. 124: 3537-44. PMID 22083140 DOI: 10.1242/Jcs.091991  0.489
2011 Fiedler M, Mendoza-Topaz C, Rutherford TJ, Mieszczanek J, Bienz M. Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin. Proceedings of the National Academy of Sciences of the United States of America. 108: 1937-42. PMID 21245303 DOI: 10.1073/Pnas.1017063108  0.534
2010 Metcalfe C, Ibrahim AE, Graeb M, de la Roche M, Schwarz-Romond T, Fiedler M, Winton DJ, Corfield A, Bienz M. Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. Cancer Research. 70: 6629-38. PMID 20663899 DOI: 10.1158/0008-5472.Can-10-1616  0.468
2010 Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M. Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor. Journal of Molecular Biology. 401: 969-84. PMID 20637214 DOI: 10.1016/J.Jmb.2010.07.007  0.329
2010 Metcalfe C, Mendoza-Topaz C, Mieszczanek J, Bienz M. Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization. Journal of Cell Science. 123: 1588-99. PMID 20388731 DOI: 10.1242/Jcs.067546  0.423
2008 Mieszczanek J, de la Roche M, Bienz M. A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription. Proceedings of the National Academy of Sciences of the United States of America. 105: 19324-9. PMID 19036929 DOI: 10.1073/Pnas.0806098105  0.529
2008 de la Roche M, Worm J, Bienz M. The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells. Bmc Cancer. 8: 199. PMID 18627596 DOI: 10.1186/1471-2407-8-199  0.362
2008 Fiedler M, Sánchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Müller J, Evans P, Bienz M. Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Molecular Cell. 30: 507-18. PMID 18498752 DOI: 10.1016/J.Molcel.2008.03.011  0.433
2008 Tran H, Hamada F, Schwarz-Romond T, Bienz M. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes & Development. 22: 528-42. PMID 18281465 DOI: 10.1101/Gad.463208  0.483
2007 Schwarz-Romond T, Metcalfe C, Bienz M. Dynamic recruitment of axin by Dishevelled protein assemblies. Journal of Cell Science. 120: 2402-12. PMID 17606995 DOI: 10.1242/Jcs.002956  0.443
2007 Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, Niehrs C. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science (New York, N.Y.). 316: 1619-22. PMID 17569865 DOI: 10.1126/Science.1137065  0.478
2007 Schwarz-Romond T, Fiedler M, Shibata N, Butler PJ, Kikuchi A, Higuchi Y, Bienz M. The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nature Structural & Molecular Biology. 14: 484-92. PMID 17529994 DOI: 10.1038/Nsmb1247  0.447
2007 de la Roche M, Bienz M. Wingless-independent association of Pygopus with dTCF target genes. Current Biology : Cb. 17: 556-61. PMID 17320388 DOI: 10.1016/J.Cub.2007.01.063  0.515
2006 Bienz M. The PHD finger, a nuclear protein-interaction domain. Trends in Biochemical Sciences. 31: 35-40. PMID 16297627 DOI: 10.1016/J.Tibs.2005.11.001  0.328
2005 Schwarz-Romond T, Merrifield C, Nichols BJ, Bienz M. The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. Journal of Cell Science. 118: 5269-77. PMID 16263762 DOI: 10.1242/Jcs.02646  0.396
2005 Hanson KK, Kelley AC, Bienz M. Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development. Development (Cambridge, England). 132: 4777-87. PMID 16224046 DOI: 10.1242/Dev.02057  0.375
2005 Bray S, Musisi H, Bienz M. Bre1 is required for Notch signaling and histone modification. Developmental Cell. 8: 279-86. PMID 15691768 DOI: 10.1016/J.Devcel.2004.11.020  0.43
2005 Bienz M. beta-Catenin: a pivot between cell adhesion and Wnt signalling. Current Biology : Cb. 15: R64-7. PMID 15668160 DOI: 10.1016/j.cub.2004.12.058  0.335
2004 Hamada F, Bienz M. The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Developmental Cell. 7: 677-85. PMID 15525529 DOI: 10.1016/j.devcel.2004.08.022  0.301
2004 Cliffe A, Mieszczanek J, Bienz M. Intracellular shuttling of a Drosophila APC tumour suppressor homolog. Bmc Cell Biology. 5: 37. PMID 15458577 DOI: 10.1186/1471-2121-5-37  0.352
2004 Bienz M, Hamada F. Adenomatous polyposis coli proteins and cell adhesion. Current Opinion in Cell Biology. 16: 528-35. PMID 15363803 DOI: 10.1016/J.Ceb.2004.08.001  0.462
2004 Townsley FM, Cliffe A, Bienz M. Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function. Nature Cell Biology. 6: 626-33. PMID 15208637 DOI: 10.1038/ncb1141  0.374
2004 Townsley FM, Thompson B, Bienz M. Pygopus residues required for its binding to Legless are critical for transcription and development. The Journal of Biological Chemistry. 279: 5177-83. PMID 14612447 DOI: 10.1074/Jbc.M309722200  0.663
2003 Cliffe A, Hamada F, Bienz M. A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling. Current Biology : Cb. 13: 960-6. PMID 12781135 DOI: 10.1016/S0960-9822(03)00370-1  0.477
2003 Bienz M, Clevers H. Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt? Nature Cell Biology. 5: 179-82. PMID 12646868 DOI: 10.1038/Ncb0303-179  0.363
2003 Rosin-Arbesfeld R, Cliffe A, Brabletz T, Bienz M. Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription. The Embo Journal. 22: 1101-13. PMID 12606575 DOI: 10.1093/emboj/cdg105  0.342
2002 Saller E, Kelley A, Bienz M. The transcriptional repressor Brinker antagonizes Wingless signaling. Genes & Development. 16: 1828-38. PMID 12130542 DOI: 10.1101/gad.230002  0.342
2002 Bienz M. The subcellular destinations of APC proteins. Nature Reviews. Molecular Cell Biology. 3: 328-38. PMID 11988767 DOI: 10.1038/Nrm806  0.438
2002 Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M. A new nuclear component of the Wnt signalling pathway. Nature Cell Biology. 4: 367-73. PMID 11988739 DOI: 10.1038/Ncb786  0.694
2002 Hamada F, Bienz M. A Drosophila APC tumour suppressor homologue functions in cellular adhesion. Nature Cell Biology. 4: 208-13. PMID 11862214 DOI: 10.1038/Ncb755  0.393
2001 Rosin-Arbesfeld R, Ihrke G, Bienz M. Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells. The Embo Journal. 20: 5929-39. PMID 11689433 DOI: 10.1093/Emboj/20.21.5929  0.313
2001 Barker N, Hurlstone A, Musisi H, Miles A, Bienz M, Clevers H. The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. The Embo Journal. 20: 4935-43. PMID 11532957 DOI: 10.1093/Emboj/20.17.4935  0.357
2001 Saller E, Bienz M. Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription. Embo Reports. 2: 298-305. PMID 11306550 DOI: 10.1093/embo-reports/kve068  0.341
2001 Freeman M, Bienz M. EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. Embo Reports. 2: 157-62. PMID 11258709 DOI: 10.1093/Embo-Reports/Kve019  0.411
2001 Bienz M. Spindles cotton on to junctions, APC and EB1. Nature Cell Biology. 3: E67-8. PMID 11231588 DOI: 10.1038/35060140  0.334
2001 Waltzer L, Vandel L, Bienz M. Teashirt is required for transcriptional repression mediated by high Wingless levels. The Embo Journal. 20: 137-45. PMID 11226164 DOI: 10.1093/emboj/20.1.137  0.306
2000 Townsley FM, Bienz M. Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo. Current Biology : Cb. 10: 1339-48. PMID 11084333 DOI: 10.1016/S0960-9822(00)00770-3  0.438
2000 Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell. 103: 311-20. PMID 11057903 DOI: 10.1016/S0092-8674(00)00122-7  0.358
2000 Szüts D, Bienz M. An autoregulatory function of Dfos during Drosophila endoderm induction. Mechanisms of Development. 98: 71-6. PMID 11044608 DOI: 10.1016/S0925-4773(00)00455-X  0.679
2000 Rosin-Arbesfeld R, Townsley F, Bienz M. The APC tumour suppressor has a nuclear export function. Nature. 406: 1009-12. PMID 10984057 DOI: 10.1038/35023016  0.479
2000 Szüts D, Bienz M. LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator. Proceedings of the National Academy of Sciences of the United States of America. 97: 5351-6. PMID 10805795 DOI: 10.1073/Pnas.97.10.5351  0.688
1999 Waltzer L, Bienz M. The control of beta-catenin and TCF during embryonic development and cancer. Cancer Metastasis Reviews. 18: 231-46. PMID 10728986 DOI: 10.1023/A:1006321324190  0.443
1999 Yu X, Waltzer L, Bienz M. A new Drosophila APC homologue associated with adhesive zones of epithelial cells. Nature Cell Biology. 1: 144-51. PMID 10559900 DOI: 10.1038/11064  0.421
1999 Bienz M. APC: the plot thickens. Current Opinion in Genetics & Development. 9: 595-603. PMID 10508699 DOI: 10.1016/S0959-437X(99)00016-7  0.423
1999 Yu X, Bienz M. Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps. Mechanisms of Development. 84: 69-73. PMID 10473121 DOI: 10.1016/S0925-4773(99)00072-6  0.302
1999 Waltzer L, Bienz M. A function of CBP as a transcriptional co-activator during Dpp signalling. The Embo Journal. 18: 1630-41. PMID 10075933 DOI: 10.1093/emboj/18.6.1630  0.385
1998 Yu X, Riese J, Eresh S, Bienz M. Transcriptional repression due to high levels of Wingless signalling. The Embo Journal. 17: 7021-32. PMID 9835654 DOI: 10.1093/emboj/17.23.7021  0.363
1998 Waltzer L, Bienz M. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature. 395: 521-5. PMID 9774110 DOI: 10.1038/26785  0.393
1998 Szüts D, Eresh S, Bienz M. Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction. Genes & Development. 12: 2022-35. PMID 9649506 DOI: 10.1101/Gad.12.13.2022  0.683
1998 Bienz M. TCF: transcriptional activator or repressor? Current Opinion in Cell Biology. 10: 366-72. PMID 9640538 DOI: 10.1016/S0955-0674(98)80013-6  0.421
1997 Eresh S, Riese J, Jackson DB, Bohmann D, Bienz M. A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction. The Embo Journal. 16: 2014-22. PMID 9155027 DOI: 10.1093/Emboj/16.8.2014  0.38
1997 Riese J, Yu X, Munnerlyn A, Eresh S, Hsu SC, Grosschedl R, Bienz M. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell. 88: 777-87. PMID 9118221 DOI: 10.1016/S0092-8674(00)81924-8  0.391
1996 Yu X, Hoppler S, Eresh S, Bienz M. decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut. Development (Cambridge, England). 122: 849-58. PMID 8631263  0.36
1993 Thüringer F, Cohen SM, Bienz M. Dissection of an indirect autoregulatory response of a homeotic Drosophila gene. The Embo Journal. 12: 2419-30. PMID 8099546  0.364
1992 Tremml G, Bienz M. Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation. Development (Cambridge, England). 116: 447-56. PMID 1363088  0.35
1990 Immerglück K, Lawrence PA, Bienz M. Induction across germ layers in Drosophila mediated by a genetic cascade. Cell. 62: 261-8. PMID 1973634 DOI: 10.1016/0092-8674(90)90364-K  0.447
1988 Bienz M, Saari G, Tremml G, Müller J, Züst B, Lawrence PA. Differential regulation of Ultrabithorax in two germ layers of Drosophila. Cell. 53: 567-76. PMID 2897241 DOI: 10.1016/0092-8674(88)90573-9  0.436
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