Niles Lehman, Ph.D. - Publications

Affiliations: 
Chemistry Portland State University, Portland, OR, United States 
Area:
Origins of Life, RNA World, RNA Recombination
Website:
http://web.pdx.edu/~niles/Lehman_Lab_at_PSU/Home.html

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mizuuchi R, Lehman N. Limited Sequence Diversity Within a Population Supports Prebiotic RNA Reproduction. Life (Basel, Switzerland). 9. PMID 30795529 DOI: 10.3390/Life9010020  0.548
2019 Mizuuchi R, Blokhuis A, Vincent L, Nghe P, Lehman N, Baum D. Mineral surfaces select for longer RNA molecules. Chemical Communications (Cambridge, England). 55: 2090-2093. PMID 30694272 DOI: 10.1039/C8Cc10319D  0.494
2019 Smail BA, Clifton BE, Mizuuchi R, Lehman N. Spontaneous advent of genetic diversity in RNA populations through multiple recombination mechanisms. Rna (New York, N.Y.). PMID 30670484 DOI: 10.1261/Rna.068908.118  0.531
2018 Arsène S, Ameta S, Lehman N, Griffiths AD, Nghe P. Coupled catabolism and anabolism in autocatalytic RNA sets. Nucleic Acids Research. PMID 29982824 DOI: 10.1093/Nar/Gky598  0.482
2017 Jayathilaka TS, Lehman N. Spontaneous covalent self-assembly of the Azoarcus ribozyme from five fragments. Chembiochem : a European Journal of Chemical Biology. PMID 29207206 DOI: 10.1002/Cbic.201700591  0.407
2017 Mathis C, Ramprasad SN, Walker SI, Lehman N. Prebiotic RNA Network Formation: A Taxonomy of Molecular Cooperation. Life (Basel, Switzerland). 7. PMID 29035326 DOI: 10.3390/Life7040038  0.439
2017 Baum DA, Lehman N. Life's Late Digital Revolution and Why It Matters for the Study of the Origins of Life. Life (Basel, Switzerland). 7. PMID 28841166 DOI: 10.3390/Life7030034  0.329
2017 Yeates JA, Nghe P, Lehman N. Topological and thermodynamic factors that influence the evolution of small networks of catalytic RNA species. Rna (New York, N.Y.). PMID 28389432 DOI: 10.1261/Rna.061093.117  0.4
2017 Lehman N. Reaction: Systematic Hope for Life’s Origins Chem. 2: 604-605. DOI: 10.1016/J.Chempr.2017.04.013  0.391
2016 Satterwhite LE, Yeates JA, Lehman N. Group I Intron Internal Guide Sequence Binding Strength as a Component of Ribozyme Network Formation. Molecules (Basel, Switzerland). 21. PMID 27689977 DOI: 10.3390/Molecules21101293  0.432
2016 Pesce D, Lehman N, de Visser JA. Sex in a test tube: testing the benefits of in vitro recombination. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 371. PMID 27619693 DOI: 10.1098/Rstb.2015.0529  0.408
2016 Yeates JA, Hilbe C, Zwick M, Nowak MA, Lehman N. Dynamics of prebiotic RNA reproduction illuminated by chemical game theory. Proceedings of the National Academy of Sciences of the United States of America. PMID 27091972 DOI: 10.1073/Pnas.1525273113  0.509
2016 Burton AS, Di Stefano M, Lehman N, Orland H, Micheletti C. The elusive quest for RNA knots. Rna Biology. 0. PMID 26828280 DOI: 10.1080/15476286.2015.1132069  0.675
2015 Lehman N. The RNA World: 4,000,000,050 years old. Life (Basel, Switzerland). 5: 1583-6. PMID 26791312 DOI: 10.3390/Life5041583  0.445
2015 Nghe P, Hordijk W, Kauffman SA, Walker SI, Schmidt FJ, Kemble H, Yeates JA, Lehman N. Prebiotic network evolution: six key parameters. Molecular Biosystems. 11: 3206-17. PMID 26490759 DOI: 10.1039/C5Mb00593K  0.331
2015 Higgs PG, Lehman N. The RNA World: molecular cooperation at the origins of life. Nature Reviews. Genetics. 16: 7-17. PMID 25385129 DOI: 10.1038/Nrg3841  0.505
2015 Lehman N, Vaidya N, Yeates JA. RNA-directed recombination of RNA in vitro. Methods in Molecular Biology (Clifton, N.J.). 1240: 27-37. PMID 25352134 DOI: 10.1007/978-1-4939-1896-6_2  0.657
2014 Lehman N, Bernhard T, Larson BC, Robinson AJ, Southgate CC. Empirical demonstration of environmental sensing in catalytic RNA: evolution of interpretive behavior at the origins of life. Bmc Evolutionary Biology. 14: 248. PMID 25471341 DOI: 10.1186/S12862-014-0248-2  0.486
2014 Di Giulio M, Lehman N. Special issue on the early evolution of life. Journal of Molecular Evolution. 79: 153-4. PMID 25428683 DOI: 10.1007/S00239-014-9657-5  0.425
2014 Hordijk W, Vaidya N, Lehman N. Serial transfer can aid the evolution of autocatalytic sets. Journal of Systems Chemistry. 5: 4. PMID 24883117 DOI: 10.1186/1759-2208-5-4  0.632
2014 Lehman N. Private funding for molecular evolution. Journal of Molecular Evolution. 78: 243-4. PMID 24817570 DOI: 10.1007/S00239-014-9624-1  0.325
2014 Díaz Arenas C, Lehman N. Correction: Partitioning the fitness components of RNA populations evolving in vitro (PLoS ONE (2013) 8, 12 (e84454) DOI: 10.1371/journal.pone.0084454) Plos One. 9. DOI: 10.1371/journal.pone.0096961  0.355
2014 Díaz Arenas C, Lehman N. Correction: Partitioning the Fitness Components of RNA Populations Evolving In Vitro Plos One. 9. DOI: 10.1371/Annotation/E97Dcbca-Dd1B-45Cb-A9A0-C2D5C9Ff88F3  0.347
2013 Díaz Arenas C, Lehman N. Partitioning the fitness components of RNA populations evolving in vitro. Plos One. 8: e84454. PMID 24391957 DOI: 10.1371/Journal.Pone.0084454  0.755
2013 Lehman N. Origin of life: Cold-hearted RNA heats up life. Nature Chemistry. 5: 987-9. PMID 24256858 DOI: 10.1038/Nchem.1811  0.464
2013 Vaidya N, Walker SI, Lehman N. Recycling of informational units leads to selection of replicators in a prebiotic soup. Chemistry & Biology. 20: 241-52. PMID 23438753 DOI: 10.1016/J.Chembiol.2013.01.007  0.639
2013 Lehman N. Editorial changes at the Journal of Molecular Evolution. Journal of Molecular Evolution. 76: 1-3. PMID 23392526 DOI: 10.1007/S00239-013-9546-3  0.396
2012 Vaidya N, Manapat ML, Chen IA, Xulvi-Brunet R, Hayden EJ, Lehman N. Spontaneous network formation among cooperative RNA replicators. Nature. 491: 72-7. PMID 23075853 DOI: 10.1038/Nature11549  0.656
2012 Lehman N. The theoretical underpinnings of primordial RNA replication: Comment on "Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life" by Takeuchi and Hogeweg. Physics of Life Reviews. 9: 274-6; discussion 27. PMID 22738813 DOI: 10.1016/J.Plrev.2012.06.011  0.48
2012 Lehman N. Evolution finds shelter in small spaces. Chemistry & Biology. 19: 439-40. PMID 22520748 DOI: 10.1016/J.Chembiol.2012.04.002  0.403
2011 Lehman N, Hayden EJ. Template-directed RNA polymerization: the taming of the milieu. Chembiochem : a European Journal of Chemical Biology. 12: 2727-8. PMID 22028272 DOI: 10.1002/Cbic.201100611  0.472
2011 Lehman N, Arenas CD, White WA, Schmidt FJ. Complexity through recombination: From chemistry to biology Entropy. 13: 17-37. DOI: 10.3390/E13010017  0.462
2010 Lehman N. RNA in evolution. Wiley Interdisciplinary Reviews. Rna. 1: 202-13. PMID 21935885 DOI: 10.1002/Wrna.37  0.516
2010 Díaz Arenas C, Lehman N. Quasispecies-like behavior observed in catalytic RNA populations evolving in a test tube. Bmc Evolutionary Biology. 10: 80. PMID 20331885 DOI: 10.1186/1471-2148-10-80  0.781
2010 Arenas CD, Lehman N. The continuous evolution in vitro technique. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 9.7.1-17. PMID 20201030 DOI: 10.1002/0471142700.Nc0907S40  0.503
2010 Burton AS, Lehman N. Enhancing the prebiotic relevance of a set of covalently self-assembling, autorecombining RNAs through in vitro selection. Journal of Molecular Evolution. 70: 233-41. PMID 20198367 DOI: 10.1007/S00239-010-9325-3  0.621
2010 Lehman N. Life from an RNA World: the ancestor within Trends in Evolutionary Biology. 2: 5. DOI: 10.4081/Eb.2010.E5  0.421
2009 Vaidya N, Lehman N. One RNA plays three roles to provide catalytic activity to a group I intron lacking an endogenous internal guide sequence. Nucleic Acids Research. 37: 3981-9. PMID 19406926 DOI: 10.1093/Nar/Gkp271  0.683
2009 Burton AS, Madix RA, Vaidya N, Riley CA, Hayden EJ, Chepetan A, Arenas CD, Larson BC, Lehman N. Gel purification of radiolabeled nucleic acids via phosphorimaging: Dip-N-Dot. Analytical Biochemistry. 388: 351-2. PMID 19232314 DOI: 10.1016/J.Ab.2009.02.010  0.67
2009 Burton AS, Lehman N. DNA before proteins? Recent discoveries in nucleic acid catalysis strengthen the case. Astrobiology. 9: 125-30. PMID 19215202 DOI: 10.1089/Ast.2008.0240  0.654
2009 Lehman N. A ghost in the RNA machine. Nature Chemical Biology. 5: 73-4. PMID 19148171 DOI: 10.1038/Nchembio0209-73  0.497
2009 Díaz Arenas C, Lehman N. Darwin's concepts in a test tube: parallels between organismal and in vitro evolution. The International Journal of Biochemistry & Cell Biology. 41: 266-73. PMID 18809507 DOI: 10.1016/J.Biocel.2008.08.034  0.756
2008 Lehman N. A recombination-based model for the origin and early evolution of genetic information. Chemistry & Biodiversity. 5: 1707-17. PMID 18816523 DOI: 10.1002/Cbdv.200890159  0.408
2008 Cernak P, Madix RA, Kuo LY, Lehman N. Accommodation of Ca(II) ions for catalytic activity by a group I ribozyme. Journal of Inorganic Biochemistry. 102: 1495-506. PMID 18295895 DOI: 10.1016/J.Jinorgbio.2008.01.011  0.364
2008 Draper WE, Hayden EJ, Lehman N. Mechanisms of covalent self-assembly of the Azoarcus ribozyme from four fragment oligonucleotides. Nucleic Acids Research. 36: 520-31. PMID 18048415 DOI: 10.1093/Nar/Gkm1055  0.354
2008 Lehman N. The molecular underpinnings of genetic phenomena. Heredity. 100: 6-12. PMID 17726489 DOI: 10.1038/Sj.Hdy.6801053  0.513
2008 Valentine K, Duffield DA, Patrick LE, Hatch DR, Butler VL, Hall RL, Lehman N. Ancient DNA reveals genotypic relationships among Oregon populations of the sea otter (Enhydra lutris) Conservation Genetics. 9: 933-938. DOI: 10.1007/S10592-007-9422-Z  0.349
2007 Zenisek SF, Hayden EJ, Lehman N. Genetic exchange leading to self-assembling RNA species upon encapsulation in artificial protocells. Artificial Life. 13: 279-89. PMID 17567246 DOI: 10.1162/Artl.2007.13.3.279  0.468
2007 Soll SJ, Díaz Arenas C, Lehman N. Accumulation of deleterious mutations in small abiotic populations of RNA. Genetics. 175: 267-75. PMID 17110480 DOI: 10.1534/Genetics.106.066142  0.757
2006 Hayden EJ, Lehman N. Self-assembly of a group I intron from inactive oligonucleotide fragments. Chemistry & Biology. 13: 909-18. PMID 16931340 DOI: 10.1016/J.Chembiol.2006.06.014  0.415
2006 Yu W, Rusterholtz KJ, Krummel AT, Lehman N. Detection of high levels of recombination generated during PCR amplification of RNA templates. Biotechniques. 40: 499-507. PMID 16629397 DOI: 10.2144/000112124  0.457
2006 Burton AS, Lehman N. Calcium(II)-dependent catalytic activity of the Azoarcus ribozyme: testing the limits of resolution for in vitro selection. Biochimie. 88: 819-25. PMID 16494986 DOI: 10.1016/J.Biochi.2006.01.010  0.588
2005 Hayden EJ, Riley CA, Burton AS, Lehman N. RNA-directed construction of structurally complex and active ligase ribozymes through recombination. Rna (New York, N.Y.). 11: 1678-87. PMID 16177133 DOI: 10.1261/Rna.2125305  0.648
2005 Lehman N, Unrau PJ. Recombination during in vitro evolution. Journal of Molecular Evolution. 61: 245-52. PMID 16007485 DOI: 10.1007/S00239-004-0373-4  0.376
2004 Weber DS, Stewart BS, Lehman N. Genetic consequences of a severe population bottleneck in the Guadalupe fur seal (Arctocephalus townsendi). The Journal of Heredity. 95: 144-53. PMID 15073230 DOI: 10.1093/Jhered/Esh018  0.361
2004 Lehman N. Assessing the likelihood of recurrence during RNA evolution in vitro. Artificial Life. 10: 1-22. PMID 15035860 DOI: 10.1162/106454604322875887  0.482
2004 Weber DS, Stewart BS, Schienman J, Lehman N. Major histocompatibility complex variation at three class II loci in the northern elephant seal. Molecular Ecology. 13: 711-8. PMID 14871373 DOI: 10.1111/J.1365-294X.2004.02095.X  0.335
2004 Lehman N, Decker DJ, Stewart BS. Divergent patterns of variation in major histocompatibility complex class II alleles among antarctic phocid pinnipeds Journal of Mammalogy. 85: 1215-1224. DOI: 10.1644/Bdw-010.1  0.357
2003 Riley CA, Lehman N. Generalized RNA-directed recombination of RNA. Chemistry & Biology. 10: 1233-43. PMID 14700631 DOI: 10.1016/J.Chembiol.2003.11.015  0.482
2003 Riley CA, Lehman N. Expanded divalent metal-ion tolerance of evolved ligase ribozymes. Biochimie. 85: 683-9. PMID 14505824 DOI: 10.1016/S0300-9084(03)00127-5  0.374
2003 Lehman N. A case for the extreme antiquity of recombination. Journal of Molecular Evolution. 56: 770-7. PMID 12911039 DOI: 10.1007/S00239-003-2454-1  0.312
2002 Maniatty WA, Caraco T, Lehman N, Szymański BK. Spatial models of persistence in RNA worlds: Exploring the origins of life Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2328: 896-903.  0.311
2000 Pfrender ME, Spitze K, Lehman N. Multi-locus genetic evidence for rapid ecologically based speciation in Daphnia. Molecular Ecology. 9: 1717-35. PMID 11091309 DOI: 10.1046/J.1365-294X.2000.01062.X  0.383
2000 Weber DS, Stewart BS, Garza JC, Lehman N. An empirical genetic assessment of the severity of the northern elephant seal population bottleneck. Current Biology : Cb. 10: 1287-90. PMID 11069110 DOI: 10.1016/S0960-9822(00)00759-4  0.369
2000 Lehman N, Donne MD, West M, Dewey TG. The genotypic landscape during in vitro evolution of a catalytic RNA: implications for phenotypic buffering. Journal of Molecular Evolution. 50: 481-90. PMID 10824092 DOI: 10.1007/S002390010051  0.493
1999 Lynch M, Pfrender M, Spitze K, Lehman N, Hicks J, Allen D, Latta L, Ottene M, Bogue F, Colbourne J. THE QUANTITATIVE AND MOLECULAR GENETIC ARCHITECTURE OF A SUBDIVIDED SPECIES. Evolution; International Journal of Organic Evolution. 53: 100-110. PMID 28565177 DOI: 10.1111/J.1558-5646.1999.Tb05336.X  0.39
1999 Schmitt T, Lehman N. Non-unity molecular heritability demonstrated by continuous evolution in vitro Chemistry and Biology. 6: 857-869. PMID 10631514 DOI: 10.1016/S1074-5521(00)80005-8  0.519
1998 Lehman N. Conservation biology: Genes are not enough Current Biology. 8: R722-R724. PMID 9778519 DOI: 10.1016/S0960-9822(98)70458-0  0.374
1995 Lehman N, Pfrender ME, Morin PA, Crease TJ, Lynch M. A hierarchical molecular phylogeny within the genus Daphnia. Molecular Phylogenetics and Evolution. 4: 395-407. PMID 8747296 DOI: 10.1006/Mpev.1995.1037  0.352
1993 Lehman N, Joyce GF. Evolution in vitro: analysis of a lineage of ribozymes Current Biology. 3: 723-734. PMID 11539560 DOI: 10.1016/0960-9822(93)90019-K  0.706
1993 Lehman N, Joyce GF. Evolution in vitro of an RNA enzyme with altered metal dependence Nature. 361: 182-185. PMID 8421526 DOI: 10.1038/361182A0  0.63
1992 Wayne RK, Lehman N, Allard MW, Honeycutt RL. Mitochondrial DNA variability of the gray wolf: genetic consequences of population decline and habitat fragmentation Conservation Biology. 6: 559-569. DOI: 10.1046/J.1523-1739.1992.06040559.X  0.328
1992 Lehman N, Clarkson P, Mech LD, Meier TJ, Wayne RK. A study of the genetic relationships within and among wolf packs using DNA fingerprinting and mitochondrial DNA Behavioral Ecology and Sociobiology. 30: 83-94. DOI: 10.1007/Bf00173944  0.334
1991 Lehman N, Eisenhawer A, Hansen K, Mech LD, Peterson RO, Gogan PJP, Wayne RK. INTROGRESSION OF COYOTE MITOCHONDRIAL DNA INTO SYMPATRIC NORTH AMERICAN GRAY WOLF POPULATIONS. Evolution; International Journal of Organic Evolution. 45: 104-119. PMID 28564062 DOI: 10.1111/J.1558-5646.1991.Tb05270.X  0.333
1991 Wayne RK, George SB, Gilbert D, Collins PW, Kovach SD, Girman D, Lehman N. A MORPHOLOGIC AND GENETIC STUDY OF THE ISLAND FOX, UROCYON LITTORALIS. Evolution; International Journal of Organic Evolution. 45: 1849-1868. PMID 28563958 DOI: 10.1111/J.1558-5646.1991.Tb02692.X  0.381
1990 Gilbert DA, Lehman N, O'Brien SJ, Wayne RK. Genetic fingerprinting reflects population differentiation in the California Channel Island fox Nature. 344: 764-766. PMID 1970419 DOI: 10.1038/344764A0  0.366
1990 Wayne RK, Meyer A, Lehman N, Van Valkenburgh B, Kat PW, Fuller TK, Girman D, O'Brien SJ. Large sequence divergence among mitochondrial DNA genotypes within populations of eastern African black-backed jackals. Proceedings of the National Academy of Sciences of the United States of America. 87: 1772-6. PMID 1968637 DOI: 10.1073/Pnas.87.5.1772  0.341
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