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Manuel Ascano, Ph.D. - Publications

Affiliations: 
2006 University of Cincinnati, Cincinnati, OH 
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Rothamel K, Arcos S, Kim B, Reasoner C, Lisy S, Mukherjee N, Ascano M. ELAVL1 primarily couples mRNA stability with the 3' UTRs of interferon-stimulated genes. Cell Reports. 35: 109178. PMID 34038724 DOI: 10.1016/j.celrep.2021.109178  0.306
2020 Kim B, Arcos S, Rothamel K, Jian J, Rose KL, McDonald WH, Bian Y, Reasoner S, Barrows NJ, Bradrick S, Garcia-Blanco MA, Ascano M. Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP. Molecular Cell. PMID 32380061 DOI: 10.1016/J.Molcel.2020.04.013  0.341
2020 Wiser C, Kim B, Vincent J, Ascano M. Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells. Scientific Reports. 10: 7604. PMID 32371942 DOI: 10.1038/S41598-020-64348-Y  0.379
2019 Barrows NJ, Anglero-Rodriguez Y, Kim B, Jamison SF, Le Sommer C, McGee CE, Pearson JL, Dimopoulos G, Ascano M, Bradrick SS, Garcia-Blanco MA. Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis. Scientific Reports. 9: 9711. PMID 31273220 DOI: 10.1038/S41598-019-45910-9  0.376
2019 Wiser C, Kim B, Ascano M. G3BP1 enhances cytoplasmic DNA pattern recognition. Nature Immunology. 20: 5-7. PMID 30538338 DOI: 10.1038/S41590-018-0279-8  0.309
2018 Mok-Lin E, Ascano M, Serganov A, Rosenwaks Z, Tuschl T, Williams Z. Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin. Scientific Reports. 8: 588. PMID 29330421 DOI: 10.1038/S41598-017-18598-Y  0.349
2017 Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, ... ... Ascano M, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nature Communications. 8: 750. PMID 28963528 DOI: 10.1038/S41467-017-00833-9  0.328
2016 Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Science Signaling. 9: ra58. PMID 27273096 DOI: 10.1126/Scisignal.Aaf6060  0.45
2016 Gao P, Ascano M, Zillinger T, Barchet W, Tuschl T, Patel DJ. Abstract B030: Structure-function studies of cytosolic DNA sensing pathway Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-B030  0.376
2015 Kavanaugh G, Zhao R, Guo Y, Mohni KN, Glick G, Lacy ME, Hutson MS, Ascano M, Cortez D. Enhancer of Rudimentary Homolog affects the replication stress response through regulation of RNA processing. Molecular and Cellular Biology. PMID 26100022 DOI: 10.1128/Mcb.01276-14  0.378
2014 Gerstberger S, Hafner M, Ascano M, Tuschl T. Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease. Advances in Experimental Medicine and Biology. 825: 1-55. PMID 25201102 DOI: 10.1007/978-1-4939-1221-6_1  0.38
2014 Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ. Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA. Cell Reports. 8: 1668-76. PMID 25199835 DOI: 10.1016/J.Celrep.2014.08.010  0.395
2014 Spitzer J, Hafner M, Landthaler M, Ascano M, Farazi T, Wardle G, Nusbaum J, Khorshid M, Burger L, Zavolan M, Tuschl T. PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins. Methods in Enzymology. 539: 113-61. PMID 24581442 DOI: 10.1016/B978-0-12-420120-0.00008-6  0.319
2013 Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell. 154: 748-62. PMID 23910378 DOI: 10.1016/J.Cell.2013.07.023  0.344
2013 Nakanishi K, Ascano M, Gogakos T, Ishibe-Murakami S, Serganov AA, Briskin D, Morozov P, Tuschl T, Patel DJ. Eukaryote-specific insertion elements control human ARGONAUTE slicer activity. Cell Reports. 3: 1893-900. PMID 23809764 DOI: 10.1016/J.Celrep.2013.06.010  0.32
2013 Ascano M, Gerstberger S, Tuschl T. Multi-disciplinary methods to define RNA-protein interactions and regulatory networks. Current Opinion in Genetics & Development. 23: 20-8. PMID 23453689 DOI: 10.1016/J.Gde.2013.01.003  0.371
2012 Ascano M, Mukherjee N, Bandaru P, Miller JB, Nusbaum JD, Corcoran DL, Langlois C, Munschauer M, Dewell S, Hafner M, Williams Z, Ohler U, Tuschl T. FMRP targets distinct mRNA sequence elements to regulate protein expression. Nature. 492: 382-6. PMID 23235829 DOI: 10.1038/Nature11737  0.422
2012 Ascano M, Hafner M, Cekan P, Gerstberger S, Tuschl T. Identification of RNA-protein interaction networks using PAR-CLIP. Wiley Interdisciplinary Reviews. Rna. 3: 159-77. PMID 22213601 DOI: 10.1002/Wrna.1103  0.408
2011 Hafner M, Ascano M, Tuschl T. New insights in the mechanism of microRNA-mediated target repression. Nature Structural & Molecular Biology. 18: 1181-2. PMID 22056803 DOI: 10.1038/Nsmb.2170  0.346
2011 Mukherjee N, Corcoran DL, Nusbaum JD, Reid DW, Georgiev S, Hafner M, Ascano M, Tuschl T, Ohler U, Keene JD. Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Molecular Cell. 43: 327-39. PMID 21723170 DOI: 10.1016/J.Molcel.2011.06.007  0.34
2011 Tian Y, Simanshu DK, Ascano M, Diaz-Avalos R, Park AY, Juranek SA, Rice WJ, Yin Q, Robinson CV, Tuschl T, Patel DJ. Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex. Nature Structural & Molecular Biology. 18: 658-64. PMID 21552261 DOI: 10.1038/Nsmb.2069  0.353
2010 Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T. PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins. Journal of Visualized Experiments : Jove. PMID 20644507 DOI: 10.3791/2034  0.345
2010 Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 141: 129-41. PMID 20371350 DOI: 10.1016/J.Cell.2010.03.009  0.376
2010 Tokhunts R, Singh S, Chu T, D'Angelo G, Baubet V, Goetz JA, Huang Z, Yuan Z, Ascano M, Zavros Y, Thérond PP, Kunes S, Dahmane N, Robbins DJ. The full-length unprocessed hedgehog protein is an active signaling molecule. The Journal of Biological Chemistry. 285: 2562-8. PMID 19920144 DOI: 10.1074/Jbc.M109.078626  0.652
2009 Farzan SF, Stegman MA, Ogden SK, Ascano M, Black KE, Tacchelly O, Robbins DJ. A quantification of pathway components supports a novel model of Hedgehog signal transduction. The Journal of Biological Chemistry. 284: 28874-84. PMID 19717563 DOI: 10.1074/Jbc.M109.041608  0.732
2008 Farzan SF, Ascano M, Ogden SK, Sanial M, Brigui A, Plessis A, Robbins DJ. Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway. Current Biology : Cb. 18: 1215-20. PMID 18691888 DOI: 10.1016/J.Cub.2008.07.026  0.672
2006 Ogden SK, Casso DJ, Ascano M, Yore MM, Kornberg TB, Robbins DJ. Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. The Journal of Biological Chemistry. 281: 7237-43. PMID 16423832 DOI: 10.1074/Jbc.M510169200  0.693
2004 Ascano M, Robbins DJ. An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling. Molecular and Cellular Biology. 24: 10397-405. PMID 15542847 DOI: 10.1128/Mcb.24.23.10397-10405.2004  0.66
2004 Ogden SK, Ascano M, Stegman MA, Robbins DJ. Regulation of Hedgehog signaling: a complex story. Biochemical Pharmacology. 67: 805-14. PMID 15104233 DOI: 10.1016/J.Bcp.2004.01.002  0.735
2004 Stegman MA, Goetz JA, Ascano M, Ogden SK, Nybakken KE, Robbins DJ. The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner. The Journal of Biological Chemistry. 279: 7064-71. PMID 14645371 DOI: 10.1074/Jbc.M311794200  0.716
2003 Ogden SK, Ascano M, Stegman MA, Suber LM, Hooper JE, Robbins DJ. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Current Biology : Cb. 13: 1998-2003. PMID 14614827 DOI: 10.1016/J.Cub.2003.10.004  0.751
2002 Ascano M, Nybakken KE, Sosinski J, Stegman MA, Robbins DJ. The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling. Molecular and Cellular Biology. 22: 1555-66. PMID 11839821 DOI: 10.1128/Mcb.22.5.1555-1566.2002  0.726
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