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Lewis C. Cantley, Ph.D.

Affiliations: 
Systems Biology Harvard University, Cambridge, MA, United States 
Area:
PI3K and cancer metabolism
Website:
http://www.fas.harvard.edu/~biophys/Lewis_Cantley.htm
Google:
"Lewis C. Cantley"
Bio:

http://sysbio.med.harvard.edu/faculty/cantley/
http://cantley.hms.harvard.edu/
http://www.pnas.org/content/101/10/3327.full

Mean distance: 8.57
 
Cross-listing: Cell Biology Tree - Evolution Tree

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Parents

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Gordon G. Hammes grad student 1975 Cornell
 (Characterization of effector binding sites on the coupling factors of oxidative phosphorylation and photophosphorylation)
Guido Guidotti post-doc 1978 Harvard

Children

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Daniel Avery Pollard research assistant 1998-2001 Harvard Medical School (Evolution Tree)
Seth J. Field grad student (Cell Biology Tree)
Bryan Ngo grad student Weil Cornell Medical College
Claudine M. Yballe grad student 2000 Harvard
Katja A. Lamia grad student 2003 Harvard
Andrew E. Elia grad student 2005 Harvard
Ji Luo grad student 2006 Harvard
Tina L. Yuan grad student 2010 Harvard
Cynthia V. Clower grad student 2011 Harvard
Peiling Tsou grad student 2011 Harvard
Shyh C. Ng grad student 2013 Harvard
Kevin D. Courtney post-doc Dana-Farber Cancer Institute (Neurotree)
Alex Toker post-doc (Cell Biology Tree)
Benjamin Turk post-doc Harvard Medical School
Matthew G. Vander Heiden post-doc Harvard Medical School
Orion D. Weiner post-doc (Neurotree)
Jihye Yun post-doc Weill Cornell Medical College
Michael B. Yaffe post-doc 1996-1998 Harvard Medical School
Bin Zheng post-doc 2003-2010 (Neurotree)
Jason W. Locasale post-doc 2008-2012 Harvard Medical School, Boston, USA (Cell Biology Tree)
Gina M DeNicola post-doc 2010-2015 Harvard Medical School - Beth Israel Deaconess Medical Center
Costas Lyssiotis post-doc 2010-2015 Harvard Medical School
Marcus DaSilva Goncalves post-doc 2014-2018 Weill Cornell Medicine (Neurotree)

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Publications

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Gattu AK, Tanzer M, Yaron-Barir TM, et al. (2025) Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes. The Journal of Clinical Investigation. 135
Hillis AL, Tamir T, Perry GE, et al. (2024) Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome. Proceedings of the National Academy of Sciences of the United States of America. 121: e2413837121
Klomp JE, Diehl JN, Klomp JA, et al. (2024) Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. Science (New York, N.Y.). 384: eadk0850
Alektiar JM, Shan M, Radyk MD, et al. (2024) Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions. Plos One. 19: e0303577
Yaron-Barir TM, Joughin BA, Huntsman EM, et al. (2024) The intrinsic substrate specificity of the human tyrosine kinome. Nature
Rogava M, Aprati TJ, Chi WY, et al. (2024) Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature Cancer
Lin TY, Ramsamooj S, Perrier T, et al. (2023) Epinephrine inhibits PI3Kα via the Hippo kinases. Cell Reports. 42: 113535
Ferrarone JR, Thomas J, Unni AM, et al. (2023) LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase. Biorxiv : the Preprint Server For Biology
Darabedian N, Ji W, Fan M, et al. (2023) Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. Nature Chemical Biology
Stein BD, Ferrarone JR, Gardner EE, et al. (2023) LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma. Cancer Discovery
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