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Nigel G. J. Richards - Publications

Affiliations: 
University of Florida, Gainesville, Gainesville, FL, United States 
 2015 Purdue University, West Lafayette, IN, United States 
 2015- Cardiff University, Cardiff, Wales, United Kingdom 
Area:
Physical Chemistry, Biochemistry
Website:
https://www.cardiff.ac.uk/people/view/144895-richards-nigel
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Jin Y, Richards NG, Waltho JP, Blackburn GM. Metal Fluorides as Analogues for Studies on Phosphoryl Transfer Enzymes. Angewandte Chemie (International Ed. in English). 56: 4110-4128. PMID 27862756 DOI: 10.1002/Anie.201606474  0.378
2016 Kumar A, Khan A, Malhotra S, Mosurkal R, Dhawan A, Pandey MK, Singh BK, Kumar R, Prasad AK, Sharma SK, Samuelson LA, Cholli AL, Len C, Richards NG, Kumar J, et al. Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives. Chemical Society Reviews. 45: 6855-6887. PMID 27785498 DOI: 10.1039/C6Cs00147E  0.337
2016 Zhu W, Easthon LM, Reinhardt LA, Tu C, Cohen SE, Silverman DN, Allen KN, Richards NG. Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase. Biochemistry. 55: 2163-73. PMID 27014926 DOI: 10.1021/Acs.Biochem.6B00043  0.631
2016 Jin Y, Molt RW, Waltho JP, Richards NG, Blackburn GM. (19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis. Angewandte Chemie (International Ed. in English). 55: 3318-22. PMID 26822702 DOI: 10.1002/Anie.201509477  0.322
2016 Zhu W, Wilcoxen J, Britt RD, Richards NG. Formation of Hexacoordinate Mn(III) in Bacillus subtilis Oxalate Decarboxylase Requires Catalytic Turnover. Biochemistry. 55: 429-34. PMID 26744902 DOI: 10.1021/Acs.Biochem.5B01340  0.584
2016 Vladimirova A, Patskovsky Y, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Hillerich B, Seidel RD, Richards NG, Almo SC, Raushel FM. Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase. Journal of the American Chemical Society. 138: 826-36. PMID 26714575 DOI: 10.1021/Jacs.5B08251  0.48
2015 Georgiadis MM, Singh I, Kellett WF, Hoshika S, Benner SA, Richards NG. Structural basis for a six nucleotide genetic alphabet. Journal of the American Chemical Society. 137: 6947-55. PMID 25961938 DOI: 10.1021/Jacs.5B03482  0.746
2015 Molt RW, Lecher AM, Clark T, Bartlett RJ, Richards NG. Facile C(sp(2))-C(sp(2)) bond cleavage in oxalic acid-derived radicals. Journal of the American Chemical Society. 137: 3248-52. PMID 25702589 DOI: 10.1021/Ja510666R  0.352
2015 Twahir UT, Stedwell CN, Lee CT, Richards NG, Polfer NC, Angerhofer A. Observation of superoxide production during catalysis of Bacillus subtilis oxalate decarboxylase at pH 4. Free Radical Biology & Medicine. 80: 59-66. PMID 25526893 DOI: 10.1016/J.Freeradbiomed.2014.12.012  0.316
2014 Miao J, Richards NG, Ge H. Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides. Chemical Communications (Cambridge, England). 50: 9687-9. PMID 25016917 DOI: 10.1039/C4Cc04349A  0.323
2014 Brunk E, Kellett WF, Richards NG, Rothlisberger U. A mechanochemical switch to control radical intermediates. Biochemistry. 53: 3830-8. PMID 24846280 DOI: 10.1021/Bi500050K  0.776
2014 Campomanes P, Kellett WF, Easthon LM, Ozarowski A, Allen KN, Angerhofer A, Rothlisberger U, Richards NG. Assigning the EPR fine structure parameters of the Mn(II) centers in Bacillus subtilis oxalate decarboxylase by site-directed mutagenesis and DFT/MM calculations. Journal of the American Chemical Society. 136: 2313-23. PMID 24444454 DOI: 10.1021/Ja408138F  0.772
2013 Hegazy L, Richards NG. Optimized CGenFF force-field parameters for acylphosphate and N-phosphonosulfonimidoyl functional groups. Journal of Molecular Modeling. 19: 5075-87. PMID 24085536 DOI: 10.1007/S00894-013-1990-X  0.317
2013 Kellett WF, Brunk E, Desai BJ, Fedorov AA, Almo SC, Gerlt JA, Rothlisberger U, Richards NG. Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase. Biochemistry. 52: 1842-4. PMID 23452154 DOI: 10.1021/Bi400093Y  0.769
2012 Ikeuchi H, Ahn YM, Otokawa T, Watanabe B, Hegazy L, Hiratake J, Richards NG. A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells. Bioorganic & Medicinal Chemistry. 20: 5915-27. PMID 22951255 DOI: 10.1016/J.Bmc.2012.07.047  0.309
2012 Saylor BT, Reinhardt LA, Lu Z, Shukla MS, Nguyen L, Cleland WW, Angerhofer A, Allen KN, Richards NG. A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase. Biochemistry. 51: 2911-20. PMID 22404040 DOI: 10.1021/Bi300001Q  0.42
2011 Moral ME, Tu C, Richards NG, Silverman DN. Membrane inlet for mass spectrometric measurement of catalysis by enzymatic decarboxylases. Analytical Biochemistry. 418: 73-7. PMID 21782782 DOI: 10.1016/J.Ab.2011.06.031  0.753
2011 Moussatche P, Angerhofer A, Imaram W, Hoffer E, Uberto K, Brooks C, Bruce C, Sledge D, Richards NG, Moomaw EW. Characterization of Ceriporiopsis subvermispora bicupin oxalate oxidase expressed in Pichia pastoris. Archives of Biochemistry and Biophysics. 509: 100-7. PMID 21376010 DOI: 10.1016/J.Abb.2011.02.022  0.79
2011 Moral ME, Tu C, Imaram W, Angerhofer A, Silverman DN, Richards NG. Nitric oxide reversibly inhibits Bacillus subtilis oxalate decarboxylase. Chemical Communications (Cambridge, England). 47: 3111-3. PMID 21264418 DOI: 10.1039/C0Cc04946H  0.768
2010 Meyer ME, Gutierrez JA, Raushel FM, Richards NG. A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase. Biochemistry. 49: 9391-401. PMID 20853825 DOI: 10.1021/Bi1010688  0.791
2010 Lee S, Chen M, Yang W, Richards NG. Sampling long time scale protein motions: OSRW simulation of active site loop conformational free energies in formyl-CoA:oxalate CoA transferase. Journal of the American Chemical Society. 132: 7252-3. PMID 20446682 DOI: 10.1021/Ja101446U  0.604
2009 Wang XS, Roitberg AE, Richards NG. Computational studies of ammonia channel function in glutamine 5'-phosphoribosylpyrophosphate amidotransferase. Biochemistry. 48: 12272-82. PMID 19921932 DOI: 10.1021/Bi901521D  0.375
2009 Moomaw EW, Angerhofer A, Moussatche P, Ozarowski A, García-Rubio I, Richards NG. Metal dependence of oxalate decarboxylase activity. Biochemistry. 48: 6116-25. PMID 19473032 DOI: 10.1021/Bi801856K  0.778
2008 Toyota CG, Berthold CL, Gruez A, Jónsson S, Lindqvist Y, Cambillau C, Richards NG. Differential substrate specificity and kinetic behavior of Escherichia coli YfdW and Oxalobacter formigenes formyl coenzyme A transferase. Journal of Bacteriology. 190: 2556-64. PMID 18245280 DOI: 10.1128/Jb.01823-07  0.799
2008 Berthold CL, Toyota CG, Richards NG, Lindqvist Y. Reinvestigation of the catalytic mechanism of formyl-CoA transferase, a class III CoA-transferase. The Journal of Biological Chemistry. 283: 6519-29. PMID 18162462 DOI: 10.1074/Jbc.M709353200  0.811
2007 Berthold CL, Toyota CG, Moussatche P, Wood MD, Leeper F, Richards NG, Lindqvist Y. Crystallographic snapshots of oxalyl-CoA decarboxylase give insights into catalysis by nonoxidative ThDP-dependent decarboxylases. Structure (London, England : 1993). 15: 853-61. PMID 17637344 DOI: 10.1016/J.Str.2007.06.001  0.819
2007 Svedruzić D, Liu Y, Reinhardt LA, Wroclawska E, Cleland WW, Richards NG. Investigating the roles of putative active site residues in the oxalate decarboxylase from Bacillus subtilis. Archives of Biochemistry and Biophysics. 464: 36-47. PMID 17459326 DOI: 10.1016/J.Abb.2007.03.016  0.802
2007 Angerhofer A, Moomaw EW, García-Rubio I, Ozarowski A, Krzystek J, Weber RT, Richards NG. Multifrequency EPR studies on the Mn(II) centers of oxalate decarboxylase. The Journal of Physical Chemistry. B. 111: 5043-6. PMID 17444678 DOI: 10.1021/Jp0715326  0.77
2007 Li KK, Beeson WT, Ghiviriga I, Richards NG. A convenient gHMQC-based NMR assay for investigating ammonia channeling in glutamine-dependent amidotransferases: studies of Escherichia coli asparagine synthetase B. Biochemistry. 46: 4840-9. PMID 17397190 DOI: 10.1021/Bi700145T  0.392
2006 Gutierrez JA, Pan YX, Koroniak L, Hiratake J, Kilberg MS, Richards NG. An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line. Chemistry & Biology. 13: 1339-47. PMID 17185229 DOI: 10.1016/J.Chembiol.2006.10.010  0.761
2006 Greene SN, Richards NG. Electronic structure, bonding, spectroscopy and energetics of Fe-dependent nitrile hydratase active-site models. Inorganic Chemistry. 45: 17-36. PMID 16390037 DOI: 10.1021/Ic050965P  0.407
2005 Borowski T, Bassan A, Richards NG, Siegbahn PE. Catalytic Reaction Mechanism of Oxalate Oxidase (Germin). A Hybrid DFT Study. Journal of Chemical Theory and Computation. 1: 686-93. PMID 26641691 DOI: 10.1021/ct050041r  0.326
2005 Berthold CL, Moussatche P, Richards NG, Lindqvist Y. Structural basis for activation of the thiamin diphosphate-dependent enzyme oxalyl-CoA decarboxylase by adenosine diphosphate. The Journal of Biological Chemistry. 280: 41645-54. PMID 16216870 DOI: 10.1074/Jbc.M509921200  0.387
2005 Ciustea M, Gutierrez JA, Abbatiello SE, Eyler JR, Richards NG. Efficient expression, purification, and characterization of C-terminally tagged, recombinant human asparagine synthetase. Archives of Biochemistry and Biophysics. 440: 18-27. PMID 16023613 DOI: 10.1016/J.Abb.2005.05.023  0.78
2005 Svedruzić D, Jónsson S, Toyota CG, Reinhardt LA, Ricagno S, Lindqvist Y, Richards NG. The enzymes of oxalate metabolism: unexpected structures and mechanisms. Archives of Biochemistry and Biophysics. 433: 176-92. PMID 15581576 DOI: 10.1016/J.Abb.2004.08.032  0.767
2004 Greene SN, Richards NG. Theoretical investigations of the electronic structure and spectroscopy of mononuclear, non-heme [Fe-NO](6) complexes. Inorganic Chemistry. 43: 7030-41. PMID 15500340 DOI: 10.1021/Ic0499695  0.347
2004 Chang CH, Svedruzic D, Ozarowski A, Walker L, Yeagle G, Britt RD, Angerhofer A, Richards NG. EPR spectroscopic characterization of the manganese center and a free radical in the oxalate decarboxylase reaction: identification of a tyrosyl radical during turnover. The Journal of Biological Chemistry. 279: 52840-9. PMID 15475346 DOI: 10.1074/Jbc.M402345200  0.793
2004 Jonsson S, Ricagno S, Lindqvist Y, Richards NG. Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes. The Journal of Biological Chemistry. 279: 36003-12. PMID 15213226 DOI: 10.1074/Jbc.M404873200  0.702
2004 Chang CH, Boone AJ, Bartlett RJ, Richards NG. Toward a computational description of nitrile hydratase: studies of the ground state bonding and spin-dependent energetics of mononuclear, non-heme Fe(III) complexes. Inorganic Chemistry. 43: 458-72. PMID 14731008 DOI: 10.1021/Ic0350032  0.765
2003 Ricagno S, Jonsson S, Richards N, Lindqvist Y. Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer. The Embo Journal. 22: 3210-9. PMID 12839984 DOI: 10.1093/Emboj/Cdg333  0.674
2003 Ricagno S, Jonsson S, Richards N, Lindqvist Y. Crystallization and preliminary crystallographic analysis of formyl-CoA tranferase from Oxalobacter formigenes. Acta Crystallographica. Section D, Biological Crystallography. 59: 1276-7. PMID 12832784 DOI: 10.1107/S0907444903009545  0.589
2003 Koroniak L, Ciustea M, Gutierrez JA, Richards NG. Synthesis and characterization of an N-acylsulfonamide inhibitor of human asparagine synthetase. Organic Letters. 5: 2033-6. PMID 12790521 DOI: 10.1021/Ol034212N  0.742
2003 Tesson AR, Soper TS, Ciustea M, Richards NG. Revisiting the steady state kinetic mechanism of glutamine-dependent asparagine synthetase from Escherichia coli. Archives of Biochemistry and Biophysics. 413: 23-31. PMID 12706338 DOI: 10.1016/S0003-9861(03)00118-8  0.794
2003 Reinhardt LA, Svedruzic D, Chang CH, Cleland WW, Richards NG. Heavy atom isotope effects on the reaction catalyzed by the oxalate decarboxylase from Bacillus subtilis. Journal of the American Chemical Society. 125: 1244-52. PMID 12553826 DOI: 10.1021/Ja0286977  0.791
2002 Schnizer HG, Boehlein SK, Stewart JD, Richards NG, Schuster SM. gamma-Glutamyl thioester intermediate in glutaminase reaction catalyzed by Escherichia coli asparagine synthetase B. Methods in Enzymology. 354: 260-71. PMID 12418233 DOI: 10.1016/S0076-6879(02)54022-2  0.428
2002 Ding Y, Wang J, Schuster SM, Richards NG. A concise synthesis of beta-asparaginyladenylate. The Journal of Organic Chemistry. 67: 4372-5. PMID 12054978 DOI: 10.1021/Jo025510L  0.369
2002 Dinculescu A, McDowell JH, Amici SA, Dugger DR, Richards N, Hargrave PA, Smith WC. Insertional mutagenesis and immunochemical analysis of visual arrestin interaction with rhodopsin. The Journal of Biological Chemistry. 277: 11703-8. PMID 11809770 DOI: 10.1074/Jbc.M111833200  0.684
2002 Aydogan B, Marshall DT, Swarts SG, Turner JE, Boone AJ, Richards NG, Bolch WE. Site-specific OH attack to the sugar moiety of DNA: a comparison of experimental data and computational simulation. Radiation Research. 157: 38-44. PMID 11754640 DOI: 10.1667/0033-7587(2002)157[0038:Ssoatt]2.0.Co;2  0.756
2001 Thirumoorthy R, Holder JR, Bauzo RM, Richards NG, Edison AS, Haskell-Luevano C. Novel agouti-related-protein-based melanocortin-1 receptor antagonist. Journal of Medicinal Chemistry. 44: 4114-24. PMID 11708914 DOI: 10.1021/Jm010215Z  0.754
2001 Boehlein SK, Nakatsu T, Hiratake J, Thirumoorthy R, Stewart JD, Richards NG, Schuster SM. Characterization of inhibitors acting at the synthetase site of Escherichia coli asparagine synthetase B. Biochemistry. 40: 11168-75. PMID 11551215 DOI: 10.1021/Bi0155551  0.789
2001 Boone AJ, Cory MG, Scott MJ, Zerner MC, Richards NG. Investigating the structural and electronic properties of nitrile hydratase model iron(III) complexes using projected unrestricted Hartree-Fock (PUHF) calculations. Inorganic Chemistry. 40: 1837-45. PMID 11312740 DOI: 10.1021/Ic0009021  0.762
1999 Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry. 38: 16146-57. PMID 10587437 DOI: 10.1021/Bi9915768  0.418
1997 Boehlein SK, Walworth ES, Richards NG, Schuster SM. Mutagenesis and chemical rescue indicate residues involved in beta-aspartyl-AMP formation by Escherichia coli asparagine synthetase B. The Journal of Biological Chemistry. 272: 12384-92. PMID 9139684 DOI: 10.1074/jbc.272.19.12384  0.316
1996 Parr IB, Boehlein SK, Dribben AB, Schuster SM, Richards NG. Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs. Journal of Medicinal Chemistry. 39: 2367-78. PMID 8691431 DOI: 10.1021/Jm9601009  0.414
1996 Boehlein SK, Schuster SM, Richards NG. Glutamic acid gamma-monohydroxamate and hydroxylamine are alternate substrates for Escherichia coli asparagine synthetase B. Biochemistry. 35: 3031-7. PMID 8608142 DOI: 10.1021/Bi952505L  0.378
1996 Stoker PW, O'Leary MH, Boehlein SK, Schuster SM, Richards NG. Probing the mechanism of nitrogen transfer in Escherichia coli asparagine synthetase by using heavy atom isotope effects. Biochemistry. 35: 3024-30. PMID 8608141 DOI: 10.1021/Bi952504T  0.427
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