Christian Melander - Publications

Affiliations: 
North Carolina State University, Raleigh, NC 
Area:
Organic Chemistry, Microbiology Biology

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Barker W, Nemeth A, Brackett S, Basak A, Chandler CE, Jania L, Zuercher W, Melander RJ, Koller B, Ernst RK, Melander C. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-negative Bacteria. Acs Infectious Diseases. PMID 31434474 DOI: 10.1021/acsinfecdis.9b00212  0.52
2019 Minrovic BM, Hubble VB, Barker WT, Jania LA, Melander RJ, Koller BH, Melander C. Second-Generation Tryptamine Derivatives Potently Sensitize Colistin Resistant Bacteria to Colistin. Acs Medicinal Chemistry Letters. 10: 828-833. PMID 31098007 DOI: 10.1021/acsmedchemlett.9b00135  0.52
2019 Nguyen TV, Peszko MT, Melander RJ, Melander C. Using 2-aminobenzimidazole derivatives to inhibit biofilm formation. Medchemcomm. 10: 456-459. PMID 31015909 DOI: 10.1039/c9md00025a  0.52
2019 Martin S, Melander RJ, Brackett C, Scott AJ, Chandler CE, Nguyen C, Minrovic B, Harrill S, Ernst RK, Manoil C, Melander C. Small Molecule Potentiation of Gram-positive Selective Antibiotics Against Acinetobacter baumannii. Acs Infectious Diseases. PMID 31002491 DOI: 10.1021/acsinfecdis.9b00067  0.52
2019 Barker WT, Chandler CE, Melander RJ, Ernst RK, Melander C. Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria. Bioorganic & Medicinal Chemistry. PMID 30898435 DOI: 10.1016/j.bmc.2019.03.019  0.52
2019 Melander CC, Nguyen TV, Minrovic BM, Melander RJ. Identification of novel anti-mycobacterial biofilm agents based upon the 2-aminoimidazole scaffold. Chemmedchem. PMID 30834698 DOI: 10.1002/cmdc.201900033  0.52
2019 Jeon AB, Ackart DF, Li W, Jackson M, Melander RJ, Melander C, Abramovitch RB, Chicco AJ, Basaraba RJ, Obregón-Henao A. 2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain. Scientific Reports. 9: 1513. PMID 30728417 DOI: 10.1038/s41598-018-38064-7  0.52
2018 Robb AJ, Vinogradov S, Danell AS, Anderson E, Blackledge MS, Melander C, Hvastkovs EG. Electrochemical Detection of Small Molecule Induced Biofilm Dispersion. Electrochimica Acta. 268: 276-282. PMID 30504968 DOI: 10.1016/j.electacta.2018.02.113  1
2018 Hubble VB, Hubbard BA, Minrovic BM, Melander RJ, Melander C. Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa. Acs Infectious Diseases. PMID 30444345 DOI: 10.1021/acsinfecdis.8b00288  0.52
2018 Huggins WM, Vu Nguyen T, Hahn NA, Baker JT, Kuo LG, Kaur D, Melander RJ, Gunn JS, Melander C. 2-Aminobenzimidazoles as antibiofilm agents against serovar Typhimurium. Medchemcomm. 9: 1547-1552. PMID 30288228 DOI: 10.1039/c8md00298c  0.52
2018 Huggins WM, Barker WT, Baker JT, Hahn NA, Melander RJ, Melander C. Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria. Acs Medicinal Chemistry Letters. 9: 702-707. PMID 30034604 DOI: 10.1021/acsmedchemlett.8b00161  0.52
2018 Minrovic BM, Jung D, Melander RJ, Melander C. A New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii. Acs Infectious Diseases. PMID 29890069 DOI: 10.1021/acsinfecdis.8b00103  0.52
2018 Martin SE, Nguyen CM, Basaraba RJ, Melander C. Analogue Synthesis Reveals Decoupling of Antibiofilm and β-Lactam Potentiation Activities of a Lead 2-Aminoimidazole Adjuvant Against Mycobacterium smegmatis. Chemical Biology & Drug Design. PMID 29663670 DOI: 10.1111/cbdd.13208  0.44
2018 Melander RJ, Zurawski DV, Melander C. Narrow-Spectrum Antibacterial Agents. Medchemcomm. 9: 12-21. PMID 29527285 DOI: 10.1039/C7MD00528H  0.52
2018 Milton ME, Minrovic BM, Harris DL, Kang B, Jung D, Lewis CP, Thompson RJ, Melander RJ, Zeng D, Melander C, Cavanagh J. Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR fromand QseB fromspp. Frontiers in Molecular Biosciences. 5: 15. PMID 29487854 DOI: 10.3389/fmolb.2018.00015  0.68
2017 Barker WT, Martin SE, Chandler CE, Nguyen TV, Harris TL, Goodell C, Melander RJ, Doi Y, Ernst RK, Melander C. Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria. Bioorganic & Medicinal Chemistry. PMID 28958847 DOI: 10.1016/j.bmc.2017.08.055  1
2017 Milton ME, Leigh Allen C, Feldmann EA, Bobay BG, Jung DK, Stephens MD, Melander RJ, Theisen KE, Zeng D, Thompson RJ, Melander C, Cavanagh J. Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. Molecular Microbiology. PMID 28755524 DOI: 10.1111/mmi.13759  0.68
2017 Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ. 2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability. Plos One. 12: e0180925. PMID 28749949 DOI: 10.1371/journal.pone.0180925  1
2017 Byrne-Nash R, Lucero D, Osbaugh N, Melander RJ, Melander C, Feldheim DL. Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered Through Small Molecule Variable Ligand Display. Bioconjugate Chemistry. PMID 28636368 DOI: 10.1021/acs.bioconjchem.7b00199  0.52
2017 Melander RJ, Melander C. The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach? Acs Infectious Diseases. PMID 28548487 DOI: 10.1021/acsinfecdis.7b00071  0.52
2017 Nguyen TV, Blackledge MS, Lindsey EA, Minrovic BM, Ackart DF, Jeon AB, Obregón-Henao A, Melander RJ, Basaraba RJ, Melander C. The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors. Angewandte Chemie (International Ed. in English). PMID 28247991 DOI: 10.1002/anie.201612006  1
2017 Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J. Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections. Drug Design, Development and Therapy. 11: 153-162. PMID 28138218 DOI: 10.2147/DDDT.S111865  0.68
2017 Huggins WM, Minrovic BM, Corey BW, Jacobs AC, Melander RJ, Sommer RD, Zurawski DV, Melander C. 1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics against Multidrug-Resistant Acinetobacter baumannii. Acs Medicinal Chemistry Letters. 8: 27-31. PMID 28105270 DOI: 10.1021/acsmedchemlett.6b00296  0.52
2016 Melander RJ, Liu HB, Stephens MD, Bewley CA, Melander C. Marine sponge alkaloids as a source of anti-bacterial adjuvants. Bioorganic & Medicinal Chemistry Letters. PMID 27876320 DOI: 10.1016/j.bmcl.2016.11.018  0.52
2016 Corey BW, Thompson MG, Hittle LE, Jacobs AC, Asafo-Adjei EA, Huggins W, Melander RJ, Melander C, Ernst RK, Zurawski DV. 1, 2, 4 -Triazolidine-3-thiones have specific activity against Acinetobacter baumannii amongst common nosocomial pathogens. Acs Infectious Diseases. PMID 27764938 DOI: 10.1021/acsinfecdis.6b00133  0.52
2016 Brackett CM, Furlani RE, Anderson RG, Krishnamurthy A, Melander RJ, Moskowitz SM, Ernst RK, Melander C. Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity. Tetrahedron. 72: 3549-3553. PMID 27429479 DOI: 10.1016/j.tet.2015.09.019  1
2016 Stephens MD, Hubble VB, Ernst RK, van Hoek ML, Melander RJ, Cavanagh J, Melander C. Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants. Medchemcomm. 7: 128-131. PMID 26877862 DOI: 10.1039/C5MD00353A  1
2015 Furlani RE, Richardson MA, Podell BK, Ackart DF, Haugen JD, Melander RJ, Basaraba RJ, Melander C. Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers. Bioorganic & Medicinal Chemistry Letters. PMID 26187705 DOI: 10.1016/j.bmcl.2015.06.080  1
2015 Richardson MA, Furlani RE, Podell BK, Ackart DF, Haugen JD, Melander RJ, Melander C, Basaraba RJ. Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives. Tetrahedron Letters. 56: 3406-3409. PMID 26146419 DOI: 10.1016/j.tetlet.2015.01.122  1
2015 Garrido C, Simpson CA, Dahl NP, Bresee J, Whitehead DC, Lindsey EA, Harris TL, Smith CA, Carter CJ, Feldheim DL, Melander C, Margolis DM. Gold nanoparticles to improve HIV drug delivery. Future Medicinal Chemistry. 7: 1097-1107. PMID 26132521 DOI: 10.4155/fmc.15.57  1
2015 Melander RJ, Melander C. From worms to targeting virulence factors. Chemistry & Biology. 22: 436-7. PMID 25910240 DOI: 10.1016/j.chembiol.2015.04.005  0.52
2015 Wahome PG, Beauchesne KR, Pedone AC, Cavanagh J, Melander C, Zimba P, Moeller PD. Augmenting anti-cancer natural products with a small molecule adjuvant. Marine Drugs. 13: 65-75. PMID 25548974 DOI: 10.3390/md13010065  0.68
2015 Melander RJ, Melander C. Innovative strategies for combating biofilm-based infections. Advances in Experimental Medicine and Biology. 831: 69-91. PMID 25384664 DOI: 10.1007/978-3-319-09782-4_6  0.52
2015 Stowe SD, Thompson RJ, Peng L, Su Z, Blackledge MS, Draughn GL, Coe WH, Johannes E, Lapham VK, Mackenzie J, Melander C, Cavanagh J. Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii. Current Drug Delivery. 12: 223-30. PMID 25348099  1
2014 Gifford JC, Bresee J, Carter CJ, Wang G, Melander RJ, Melander C, Feldheim DL. Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis. Chemical Communications (Cambridge, England). 50: 15860-3. PMID 25350535 DOI: 10.1039/c4cc06236a  1
2014 Melander RJ, Minvielle MJ, Melander C. Controlling bacterial behavior with indole-containing natural products and derivatives. Tetrahedron. 70: 6363-6372. PMID 25267859 DOI: 10.1016/j.tet.2014.05.089  1
2014 Brackett CM, Melander RJ, An IH, Krishnamurthy A, Thompson RJ, Cavanagh J, Melander C. Small-molecule suppression of β-lactam resistance in multidrug-resistant gram-negative pathogens. Journal of Medicinal Chemistry. 57: 7450-8. PMID 25137478 DOI: 10.1021/jm501050e  1
2014 Bresee J, Bond CM, Worthington RJ, Smith CA, Gifford JC, Simpson CA, Carter CJ, Wang G, Hartman J, Osbaugh NA, Shoemaker RK, Melander C, Feldheim DL. Nanoscale structure-activity relationships, mode of action, and biocompatibility of gold nanoparticle antibiotics. Journal of the American Chemical Society. 136: 5295-300. PMID 24624950 DOI: 10.1021/ja408505n  1
2014 Ackart DF, Hascall-Dove L, Caceres SM, Kirk NM, Podell BK, Melander C, Orme IM, Leid JG, Nick JA, Basaraba RJ. Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis Pathogens and Disease. 70: 359-369. PMID 24478060 DOI: 10.1111/2049-632X.12144  1
2014 Ackart DF, Lindsey EA, Podell BK, Melander RJ, Basaraba RJ, Melander C. Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules. Pathogens and Disease. 70: 370-8. PMID 24478046 DOI: 10.1111/2049-632X.12143  0.56
2014 Harris TL, Worthington RJ, Hittle LE, Zurawski DV, Ernst RK, Melander C. Small molecule downregulation of PmrAB reverses lipid a modification and breaks colistin resistance Acs Chemical Biology. 9: 122-127. PMID 24131198 DOI: 10.1021/cb400490k  1
2014 Olson AL, Thompson RJ, Melander C, Cavanagh J. Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii. Biomolecular Nmr Assignments. 8: 67-70. PMID 23264007 DOI: 10.1007/s12104-012-9454-2  1
2013 Minvielle MJ, Eguren K, Melander C. Highly active modulators of indole signaling alter pathogenic behaviors in Gram-negative and Gram-positive bacteria. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 17595-602. PMID 24243627 DOI: 10.1002/chem.201303510  1
2013 Minvielle MJ, Bunders CA, Melander C. Indole/triazole conjugates are selective inhibitors and inducers of bacterial biofilms. Medchemcomm. 4: 916-919. PMID 23930199 DOI: 10.1039/C3MD00064H  1
2013 Blackledge MS, Worthington RJ, Melander C. Biologically inspired strategies for combating bacterial biofilms. Current Opinion in Pharmacology. 13: 699-706. PMID 23871261 DOI: 10.1016/j.coph.2013.07.004  1
2013 Worthington RJ, Blackledge MS, Melander C. Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence. Future Medicinal Chemistry. 5: 1265-84. PMID 23859207 DOI: 10.4155/fmc.13.58  1
2013 Blackledge MS, Melander C. Programmable DNA-binding small molecules. Bioorganic & Medicinal Chemistry. 21: 6101-14. PMID 23665141 DOI: 10.1016/j.bmc.2013.04.023  1
2013 Worthington RJ, Melander C. Overcoming resistance to β-lactam antibiotics. The Journal of Organic Chemistry. 78: 4207-13. PMID 23530949 DOI: 10.1021/jo400236f  1
2013 Furlani RE, Yeagley AA, Melander C. A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria. European Journal of Medicinal Chemistry. 62: 59-70. PMID 23353733 DOI: 10.1016/j.ejmech.2012.12.005  1
2013 Worthington RJ, Melander C. Combination approaches to combat multidrug-resistant bacteria. Trends in Biotechnology. 31: 177-84. PMID 23333434 DOI: 10.1016/j.tibtech.2012.12.006  1
2013 Yeagley AA, Su Z, McCullough KD, Worthington RJ, Melander C. N-substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization. Organic & Biomolecular Chemistry. 11: 130-7. PMID 23076976 DOI: 10.1039/c2ob26469b  1
2012 Thompson RJ, Bobay BG, Stowe SD, Olson AL, Peng L, Su Z, Actis LA, Melander C, Cavanagh J. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 51: 9776-8. PMID 23186243 DOI: 10.1021/bi3015289  1
2012 Lindsey EA, Brackett CM, Mullikin T, Alcaraz C, Melander C. The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors. Medchemcomm. 3: 1462-1465. PMID 23162679 DOI: 10.1039/C2MD20244A  1
2012 Harris TL, Worthington RJ, Melander C. Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus. Angewandte Chemie (International Ed. in English). 51: 11254-7. PMID 23047322 DOI: 10.1002/anie.201206911  1
2012 Su Z, Yeagley AA, Su R, Peng L, Melander C. Structural studies on 4,5-disubstituted 2-aminoimidazole-based biofilm modulators that suppress bacterial resistance to β-lactams. Chemmedchem. 7: 2030-9. PMID 23011973 DOI: 10.1002/cmdc.201200350  1
2012 Melander C, Margolis DM. Medicinal chemistry: Forcing an enemy into the open. Nature Chemistry. 4: 692-3. PMID 22914185 DOI: 10.1038/nchem.1444  0.56
2012 Worthington RJ, Bunders CA, Reed CS, Melander C. Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae. Acs Medicinal Chemistry Letters. 3: 357-361. PMID 22844552 DOI: 10.1021/ml200290p  1
2012 Worthington RJ, Richards JJ, Melander C. Small molecule control of bacterial biofilms. Organic & Biomolecular Chemistry. 10: 7457-74. PMID 22733439 DOI: 10.1039/c2ob25835h  1
2012 Worthington RJ, Melander C. Deconvoluting interspecies bacterial communication. Angewandte Chemie (International Ed. in English). 51: 6314-5. PMID 22644666 DOI: 10.1002/anie.201202440  1
2012 Lindsey EA, Worthington RJ, Alcaraz C, Melander C. 2-Aminopyrimidine as a novel scaffold for biofilm modulation. Organic & Biomolecular Chemistry. 10: 2552-61. PMID 22301774 DOI: 10.1039/c2ob06871k  1
2012 Stowe SD, Tucker AT, Thompson R, Piper A, Richards JJ, Rogers SA, Mathies LD, Melander C, Cavanagh J. Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems. Drug and Chemical Toxicology. 35: 310-5. PMID 22292413 DOI: 10.3109/01480545.2011.614620  1
2012 Olson AL, Bobay BG, Melander C, Cavanagh J. 1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis Biomolecular Nmr Assignments. 6: 95-98. PMID 21845362 DOI: 10.1007/s12104-011-9333-2  1
2011 Bunders CA, Minvielle MJ, Worthington RJ, Ortiz M, Cavanagh J, Melander C. Intercepting bacterial indole signaling with flustramine derivatives. Journal of the American Chemical Society. 133: 20160-3. PMID 22091927 DOI: 10.1021/ja209836z  1
2011 Stowe SD, Richards JJ, Tucker AT, Thompson R, Melander C, Cavanagh J. Anti-biofilm compounds derived from marine sponges. Marine Drugs. 9: 2010-35. PMID 22073007 DOI: 10.3390/md9102010  1
2011 Su Z, Peng L, Worthington RJ, Melander C. Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii. Chemmedchem. 6: 2243-51. PMID 21928438 DOI: 10.1002/cmdc.201100316  1
2011 Harris TL, Worthington RJ, Melander C. A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: antibiotic activity of a first generation library. Bioorganic & Medicinal Chemistry Letters. 21: 4516-9. PMID 21737267 DOI: 10.1016/j.bmcl.2011.05.123  1
2011 Bunders C, Cavanagh J, Melander C. Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms. Organic & Biomolecular Chemistry. 9: 5476-81. PMID 21674109 DOI: 10.1039/c1ob05605k  0.68
2011 Bresee J, Maier KE, Boncella AE, Melander C, Feldheim DL. Growth inhibition of Staphylococcus aureus by mixed monolayer gold nanoparticles. Small (Weinheim An Der Bergstrasse, Germany). 7: 2027-31. PMID 21630443 DOI: 10.1002/smll.201100420  1
2011 Peng L, DeSousa J, Su Z, Novak BM, Nevzorov AA, Garland ER, Melander C. Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit. Chemical Communications (Cambridge, England). 47: 4896-8. PMID 21442111 DOI: 10.1039/c1cc10691k  1
2011 Liu C, Worthington RJ, Melander C, Wu H. A new small molecule specifically inhibits the cariogenic bacterium Streptococcus mutans in multispecies biofilms. Antimicrobial Agents and Chemotherapy. 55: 2679-87. PMID 21402858 DOI: 10.1128/AAC.01496-10  1
2011 Reyes S, Huigens RW, Su Z, Simon ML, Melander C. Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling. Organic & Biomolecular Chemistry. 9: 3041-9. PMID 21394327 DOI: 10.1039/c0ob00925c  0.84
2011 Rogers SA, Lindsey EA, Whitehead DC, Mullikin T, Melander C. Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents. Bioorganic & Medicinal Chemistry Letters. 21: 1257-60. PMID 21251823 DOI: 10.1016/j.bmcl.2010.12.057  1
2010 Reed CS, Huigens RW, Rogers SA, Melander C. Modulating the development of E. coli biofilms with 2-aminoimidazoles. Bioorganic & Medicinal Chemistry Letters. 20: 6310-2. PMID 20846860 DOI: 10.1016/j.bmcl.2010.08.075  0.84
2010 Bresee J, Maier KE, Melander C, Feldheim DL. Identification of antibiotics using small molecule variable ligand display on gold nanoparticles. Chemical Communications (Cambridge, England). 46: 7516-8. PMID 20835461 DOI: 10.1039/c0cc02663h  1
2010 Rogers SA, Whitehead DC, Mullikin T, Melander C. Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives. Organic & Biomolecular Chemistry. 8: 3857-9. PMID 20617245 DOI: 10.1039/c0ob00063a  1
2010 Bunders CA, Richards JJ, Melander C. Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria. Bioorganic & Medicinal Chemistry Letters. 20: 3797-800. PMID 20466544 DOI: 10.1016/j.bmcl.2010.04.042  1
2010 Su Z, Rogers SA, McCall WS, Smith AC, Ravishankar S, Mullikin T, Melander C. A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity. Organic & Biomolecular Chemistry. 8: 2814-22. PMID 20428587 DOI: 10.1039/c001479f  1
2010 Rogers SA, Huigens RW, Cavanagh J, Melander C. Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents. Antimicrobial Agents and Chemotherapy. 54: 2112-8. PMID 20211901 DOI: 10.1128/AAC.01418-09  0.84
2010 Rogers SA, Bero JD, Melander C. Chemical synthesis and biological screening of 2-aminoimidazole-based bacterial and fungal antibiofilm agents. Chembiochem : a European Journal of Chemical Biology. 11: 396-410. PMID 20049758 DOI: 10.1002/cbic.200900617  0.68
2010 Huigens RW, Reyes S, Reed CS, Bunders C, Rogers SA, Steinhauer AT, Melander C. The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii. Bioorganic & Medicinal Chemistry. 18: 663-74. PMID 20044260 DOI: 10.1016/j.bmc.2009.12.003  1
2009 Melander C, Moeller PD, Ballard TE, Richards JJ, Huigens RW, Cavanagh J. Evaluation of dihydrooroidin as an antifouling additive in marine paint. International Biodeterioration & Biodegradation. 63: 529-532. PMID 23874076 DOI: 10.1016/j.ibiod.2008.08.009  1
2009 Richards JJ, Reyes S, Stowe SD, Tucker AT, Ballard TE, Mathies LD, Cavanagh J, Melander C. Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity. Journal of Medicinal Chemistry. 52: 4582-5. PMID 19719234 DOI: 10.1021/jm900378s  1
2009 Richards JJ, Melander C. Controlling bacterial biofilms. Chembiochem : a European Journal of Chemical Biology. 10: 2287-94. PMID 19681090 DOI: 10.1002/cbic.200900317  1
2009 Rogers SA, Huigens RW, Melander C. A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism. Journal of the American Chemical Society. 131: 9868-9. PMID 19621946 DOI: 10.1021/ja9024676  0.84
2009 Huigens RW, Rogers SA, Steinhauer AT, Melander C. Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates. Organic & Biomolecular Chemistry. 7: 794-802. PMID 19194596 DOI: 10.1039/b817926c  1
2009 Rogers SA, Krayer M, Lindsey JS, Melander C. Tandem dispersion and killing of bacteria from a biofilm Organic and Biomolecular Chemistry. 7: 603-606. PMID 19156328 DOI: 10.1039/b817923a  1
2009 Ballard TE, Richards JJ, Aquino A, Reed CS, Melander C. Antibiofilm activity of a diverse oroidin library generated through reductive acylation. The Journal of Organic Chemistry. 74: 1755-8. PMID 19132935 DOI: 10.1021/jo802260t  1
2008 Ballard TE, Richards JJ, Wolfe AL, Melander C. Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 10745-61. PMID 18942682 DOI: 10.1002/chem.200801419  1
2008 Richards JJ, Reed CS, Melander C. Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii. Bioorganic & Medicinal Chemistry Letters. 18: 4325-7. PMID 18625555 DOI: 10.1016/j.bmcl.2008.06.089  1
2008 Rogers SA, Melander C. Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum. Angewandte Chemie (International Ed. in English). 47: 5229-31. PMID 18528836 DOI: 10.1002/anie.200800862  0.68
2008 Richards JJ, Melander C. Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the Sonogashira reaction. The Journal of Organic Chemistry. 73: 5191-3. PMID 18522427 DOI: 10.1021/jo800618q  1
2008 Huigens RW, Ma L, Gambino C, Moeller PD, Basso A, Cavanagh J, Wozniak DJ, Melander C. Control of bacterial biofilms with marine alkaloid derivatives. Molecular Biosystems. 4: 614-21. PMID 18493660 DOI: 10.1039/b719989a  1
2008 Bowman MC, Ballard TE, Ackerson CJ, Feldheim DL, Margolis DM, Melander C. Inhibition of HIV fusion with multivalent gold nanoparticles. Journal of the American Chemical Society. 130: 6896-7. PMID 18473457 DOI: 10.1021/ja710321g  1
2008 Richards JJ, Ballard TE, Huigens RW, Melander C. Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms. Chembiochem : a European Journal of Chemical Biology. 9: 1267-79. PMID 18431726 DOI: 10.1002/cbic.200700774  1
2008 Richards JJ, Ballard TE, Melander C. Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues. Organic & Biomolecular Chemistry. 6: 1356-63. PMID 18385842 DOI: 10.1039/b719082d  1
2008 Richards JJ, Huigens Iii RW, Ballard TE, Basso A, Cavanagh J, Melander C. Inhibition and dispersion of proteobacterial biofilms. Chemical Communications (Cambridge, England). 1698-700. PMID 18368169 DOI: 10.1039/b719802g  1
2008 Burns VA, Bobay BG, Basso A, Cavanagh J, Melander C. Targeting RNA with cysteine-constrained peptides. Bioorganic & Medicinal Chemistry Letters. 18: 565-7. PMID 18065222 DOI: 10.1016/j.bmcl.2007.11.096  0.68
2007 Huigens RW, Richards JJ, Parise G, Ballard TE, Zeng W, Deora R, Melander C. Inhibition of Pseudomonas aeruginosa biofilm formation with Bromoageliferin analogues. Journal of the American Chemical Society. 129: 6966-7. PMID 17500516 DOI: 10.1021/ja069017t  1
2006 Zeng W, Eric Ballard T, Tkachenko AG, Burns VA, Feldheim DL, Melander C. Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs. Bioorganic & Medicinal Chemistry Letters. 16: 5148-51. PMID 16870443 DOI: 10.1016/j.bmcl.2006.07.024  1
2006 Burnett R, Melander C, Puckett JW, Son LS, Wells RD, Dervan PB, Gottesfeld JM. DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proceedings of the National Academy of Sciences of the United States of America. 103: 11497-502. PMID 16857735 DOI: 10.1073/pnas.0604939103  1
2005 Gearhart MD, Dickinson L, Ehley J, Melander C, Dervan PB, Wright PE, Gottesfeld JM. Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry. 44: 4196-203. PMID 15766247 DOI: 10.1021/bi047872o  1
2004 Dickinson LA, Burnett R, Melander C, Edelson BS, Arora PS, Dervan PB, Gottesfeld JM. Arresting cancer proliferation by small-molecule gene regulation. Chemistry & Biology. 11: 1583-94. PMID 15556009 DOI: 10.1016/j.chembiol.2004.09.004  1
2004 Ylisastigui L, Coull JJ, Rucker VC, Melander C, Bosch RJ, Brodie SJ, Corey L, Sodora DL, Dervan PB, Margolis DM. Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. The Journal of Infectious Diseases. 190: 1429-37. PMID 15378435 DOI: 10.1086/423822  1
2004 Melander C, Burnett R, Gottesfeld JM. Regulation of gene expression with pyrrole-imidazole polyamides. Journal of Biotechnology. 112: 195-220. PMID 15288953 DOI: 10.1016/j.jbiotec.2004.03.018  1
2003 Dudouet B, Burnett R, Dickinson LA, Wood MR, Melander C, Belitsky JM, Edelson B, Wurtz N, Briehn C, Dervan PB, Gottesfeld JM. Accessibility of nuclear chromatin by DNA binding polyamides. Chemistry & Biology. 10: 859-67. PMID 14522056 DOI: 10.1016/j.chembiol.2003.09.001  1
2003 Suto RK, Edayathumangalam RS, White CL, Melander C, Gottesfeld JM, Dervan PB, Luger K. Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. Journal of Molecular Biology. 326: 371-80. PMID 12559907 DOI: 10.1016/S0022-2836(02)01407-9  1
2003 Rucker VC, Foister S, Melander C, Dervan PB. Sequence specific fluorescence detection of double strand DNA. Journal of the American Chemical Society. 125: 1195-202. PMID 12553822 DOI: 10.1021/ja021011q  1
2002 Coull JJ, He G, Melander C, Rucker VC, Dervan PB, Margolis DM. Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. Journal of Virology. 76: 12349-54. PMID 12414976 DOI: 10.1128/JVI.76.23.12349-12354.2002  1
2002 Gottesfeld JM, Belitsky JM, Melander C, Dervan PB, Luger K. Blocking transcription through a nucleosome with synthetic DNA ligands. Journal of Molecular Biology. 321: 249-63. PMID 12144782 DOI: 10.1016/S0022-2836(02)00598-3  1
2002 Ehley JA, Melander C, Herman D, Baird EE, Ferguson HA, Goodrich JA, Dervan PB, Gottesfeld JM. Promoter scanning for transcription inhibition with DNA-binding polyamides. Molecular and Cellular Biology. 22: 1723-33. PMID 11865052 DOI: 10.1128/MCB.22.6.1723-1733.2002  1
1996 Melander C, Horne DA. Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. The Journal of Organic Chemistry. 61: 8344-8346. PMID 11667834  1
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