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Thomas S. Dexheimer, Ph.D. - Publications

Affiliations: 
2006 University of Arizona, Tucson, AZ 
Area:
Pharmacy, Molecular Biology
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54/75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dexheimer TS, Coussens NP, Silvers T, Wright J, Morris J, Doroshow JH, Teicher BA. Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs. Cancer Research Communications. 3: 1648-1661. PMID 37637936 DOI: 10.1158/2767-9764.CRC-23-0193  0.407
2020 Liu M, Sui D, Dexheimer T, Hovde S, Deng X, Wang KW, Lin HL, Chien HT, Kweon HK, Kuo NS, Ayoub CA, Jimenez-Harrison D, Andrews PC, Kwok R, Bochar DA, et al. Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death. Molecular Neurobiology. PMID 32780352 DOI: 10.1007/S12035-020-02034-W  0.557
2019 Sommers JA, Kulikowicz T, Croteau DL, Dexheimer T, Dorjsuren D, Jadhav A, Maloney DJ, Simeonov A, Bohr VA, Brosh RM. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). Plos One. 14: e0210525. PMID 30625228 DOI: 10.1371/Journal.Pone.0210525  0.515
2018 Kiselev E, Dexheimer TS, Marchand C, Huang SN, Pommier Y. Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3'- and 5'-phosphodiester-DNA bond cleavage. Dna Repair. 66: 64-71. PMID 29747024 DOI: 10.1016/J.Dnarep.2018.05.001  0.397
2018 Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Science Translational Medicine. 10. PMID 29444979 DOI: 10.1126/Scitranslmed.Aaf7444  0.391
2017 Jun JH, Kumar V, Dexheimer TS, Wedlich I, Nicklaus MC, Pommier Y, Malhotra SV. Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29037996 DOI: 10.1016/J.Ejps.2017.10.017  0.434
2015 Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, et al. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays. Plos One. 10: e0130796. PMID 26177200 DOI: 10.1371/Journal.Pone.0130796  0.33
2014 Gormally MV, Dexheimer TS, Marsico G, Sanders DA, Lowe C, Matak-Vinkovi? D, Michael S, Jadhav A, Rai G, Maloney DJ, Simeonov A, Balasubramanian S. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nature Communications. 5: 5165. PMID 25387393 DOI: 10.1038/Ncomms6165  0.432
2014 Guo D, Dexheimer TS, Pommier Y, Nash HA. Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1). Proceedings of the National Academy of Sciences of the United States of America. 111: 15816-20. PMID 25331878 DOI: 10.1073/Pnas.1415011111  0.446
2014 Dexheimer TS, Rosenthal AS, Luci DK, Liang Q, Villamil MA, Chen J, Sun H, Kerns EH, Simeonov A, Jadhav A, Zhuang Z, Maloney DJ. Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. Journal of Medicinal Chemistry. 57: 8099-110. PMID 25229643 DOI: 10.1021/Jm5010495  0.443
2014 Carver J, Dexheimer TS, Hsu D, Weng MT, Smith JL, Guha R, Jadhav A, Simeonov A, Luo J. A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein. Plos One. 9: e103836. PMID 25093678 DOI: 10.1371/Journal.Pone.0103836  0.31
2014 Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, et al. Biochemical assays for the discovery of TDP1 inhibitors. Molecular Cancer Therapeutics. 13: 2116-26. PMID 25024006 DOI: 10.1158/1535-7163.Mct-13-0952  0.465
2014 Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nature Chemical Biology. 10: 298-304. PMID 24531842 DOI: 10.1038/Nchembio.1455  0.485
2014 Dexheimer TS, Rosenthal AS, Luci D, Liang Q, Villamil MA, Jadhav A, Simeonov A, Zhuang Z, Maloney DJ. Abstract LB-11: Discovery, synthesis, and structure-activity relationship of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against non-small cell lung cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-11  0.435
2014 Dexheimer TS. DNA repair pathways and mechanisms Dna Repair of Cancer Stem Cells. 19-32. DOI: 10.1007/978-94-007-4590-2_2  0.346
2013 Rosenthal AS, Dexheimer TS, Gileadi O, Nguyen GH, Chu WK, Hickson ID, Jadhav A, Simeonov A, Maloney DJ. Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorganic & Medicinal Chemistry Letters. 23: 5660-6. PMID 24012121 DOI: 10.1016/J.Bmcl.2013.08.025  0.536
2013 Huang SY, Murai J, Dalla Rosa I, Dexheimer TS, Naumova A, Gmeiner WH, Pommier Y. TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. Nucleic Acids Research. 41: 7793-803. PMID 23775789 DOI: 10.1093/Nar/Gkt483  0.436
2013 Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, et al. A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chemistry & Biology. 20: 55-62. PMID 23352139 DOI: 10.1016/J.Chembiol.2012.10.016  0.439
2013 Huang SN, Murai J, Rosa ID, Dexheimer TS, Gmeiner WH, Pommier Y. Abstract C79: TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C79  0.439
2012 Murai J, Huang SY, Das BB, Dexheimer TS, Takeda S, Pommier Y. Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells. The Journal of Biological Chemistry. 287: 12848-57. PMID 22375014 DOI: 10.1074/Jbc.M111.333963  0.463
2011 Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A, Zhuang Z. Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chemistry & Biology. 18: 1390-400. PMID 22118673 DOI: 10.1016/J.Chembiol.2011.08.014  0.419
2011 Kiselev E, DeGuire S, Morrell A, Agama K, Dexheimer TS, Pommier Y, Cushman M. 7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents. Journal of Medicinal Chemistry. 54: 6106-16. PMID 21823606 DOI: 10.1021/Jm200719V  0.495
2011 Peterson KE, Cinelli MA, Morrell AE, Mehta A, Dexheimer TS, Agama K, Antony S, Pommier Y, Cushman M. Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. Journal of Medicinal Chemistry. 54: 4937-53. PMID 21710981 DOI: 10.1021/Jm101338Z  0.429
2011 Guha R, Dexheimer TS, Kestranek AN, Jadhav A, Chervenak AM, Ford MG, Simeonov A, Roth GP, Thomas CJ. Exploratory analysis of kinetic solubility measurements of a small molecule library. Bioorganic & Medicinal Chemistry. 19: 4127-34. PMID 21640593 DOI: 10.1016/J.Bmc.2011.05.005  0.319
2011 Sooryakumar D, Dexheimer TS, Teicher BA, Pommier Y. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Molecular Cancer Therapeutics. 10: 1490-9. PMID 21636699 DOI: 10.1158/1535-7163.Mct-10-1043  0.462
2011 Prast-Nielsen S, Dexheimer TS, Schultz L, Stafford WC, Cheng Q, Xu J, Jadhav A, Arnér ES, Simeonov A. Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. Free Radical Biology & Medicine. 50: 1114-23. PMID 21262347 DOI: 10.1016/J.Freeradbiomed.2011.01.020  0.401
2010 Weidlich IE, Dexheimer TS, Marchand C, Antony S, Pommier Y, Nicklaus MC. Virtual screening using ligand-based pharmacophores for inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1). Bioorganic & Medicinal Chemistry. 18: 2347-2355. PMID 30025429 DOI: 10.1016/J.Bmc.2010.02.009  0.461
2010 Kiselev E, Dexheimer TS, Pommier Y, Cushman M. Design, synthesis, and evaluation of dibenzo[c,h][1,6]naphthyridines as topoisomerase I inhibitors and potential anticancer agents. Journal of Medicinal Chemistry. 53: 8716-26. PMID 21090809 DOI: 10.1021/Jm101048K  0.468
2010 Das BB, Dexheimer TS, Maddali K, Pommier Y. Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 107: 19790-5. PMID 21041670 DOI: 10.1073/Pnas.1009814107  0.444
2010 Cinelli MA, Morrell AE, Dexheimer TS, Agama K, Agrawal S, Pommier Y, Cushman M. The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode. Bioorganic & Medicinal Chemistry. 18: 5535-52. PMID 20630766 DOI: 10.1016/J.Bmc.2010.06.040  0.414
2010 Song Y, Shao Z, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors. Journal of Medicinal Chemistry. 53: 1979-89. PMID 20155916 DOI: 10.1021/Jm901649X  0.404
2010 Gheeya J, Johansson P, Chen QR, Dexheimer T, Metaferia B, Song YK, Wei JS, He J, Pommier Y, Khan J. Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor Cancer Letters. 293: 124-131. PMID 20133050 DOI: 10.1016/J.Canlet.2010.01.004  0.512
2010 Dexheimer TS, Stephen AG, Fivash MJ, Fisher RJ, Pommier Y. The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase. Nucleic Acids Research. 38: 2444-52. PMID 20097655 DOI: 10.1093/Nar/Gkp1206  0.446
2010 Weidlich IE, Dexheimer T, Marchand C, Antony S, Pommier Y, Nicklaus MC. Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores. Bioorganic & Medicinal Chemistry. 18: 182-9. PMID 19963390 DOI: 10.1016/J.Bmc.2009.11.008  0.458
2010 Weidlich IE, Dexheimer TS, Marchand C, Antony S, Pommier Y, Nicklaus MC. Virtual screening using ligand-based pharmacophores for inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) (DOI:10.1016/j.bmc.2010.02.008) Bioorganic and Medicinal Chemistry. 18: 2347-2355. DOI: 10.1016/j.bmc.2010.02.009  0.37
2010 Weidlich IE, Dexheimer T, Marchand C, Antony S, Pommier Y, Nicklaus MC. Corrigendum to "Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores" [Bioorg. Med. Chem. 18 (2010) 182-189] Bioorganic and Medicinal Chemistry. 18: 2346. DOI: 10.1016/J.Bmc.2010.02.008  0.42
2009 Dexheimer TS, Gediya LK, Stephen AG, Weidlich I, Antony S, Marchand C, Interthal H, Nicklaus M, Fisher RJ, Njar VC, Pommier Y. 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Journal of Medicinal Chemistry. 52: 7122-31. PMID 19883083 DOI: 10.1021/Jm901061S  0.517
2009 Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y. Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. The Embo Journal. 28: 3667-80. PMID 19851285 DOI: 10.1038/Emboj.2009.302  0.451
2009 Cinelli MA, Cordero B, Dexheimer TS, Pommier Y, Cushman M. Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships. Bioorganic & Medicinal Chemistry. 17: 7145-55. PMID 19783447 DOI: 10.1016/J.Bmc.2009.08.066  0.383
2009 Dexheimer TS, Carey SS, Zuohe S, Gokhale VM, Hu X, Murata LB, Maes EM, Weichsel A, Sun D, Meuillet EJ, Montfort WR, Hurley LH. NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1). Molecular Cancer Therapeutics. 8: 1363-77. PMID 19435876 DOI: 10.1158/1535-7163.Mct-08-1093  0.561
2009 Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay. Molecular Cancer Therapeutics. 8: 240-8. PMID 19139134 DOI: 10.1158/1535-7163.Mct-08-0878  0.493
2009 Sooryakumar D, Dexheimer T, Teicher BA, Pommier Y. Abstract C219: Molecular and cellular pharmacology of the novel non‐camptothecin topoisomerase I inhibitor, GENZ644282 Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C219  0.395
2009 Stephen AG, Dexheimer TS, Marchand C, Pommier Y, Fisher RJ. Tyrosyl-DNA Phosphodiesterase Binds Nucleic Acids Preferentially At The 3′ End Biophysical Journal. 96: 417a. DOI: 10.1016/J.Bpj.2008.12.2132  0.373
2008 Dexheimer TS, Pommier Y. DNA cleavage assay for the identification of topoisomerase I inhibitors. Nature Protocols. 3: 1736-50. PMID 18927559 DOI: 10.1038/Nprot.2008.174  0.51
2008 Goswami A, Qiu S, Dexheimer TS, Ranganathan P, Burikhanov R, Pommier Y, Rangnekar VM. Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity. Cancer Research. 68: 6190-8. PMID 18676842 DOI: 10.1158/0008-5472.Can-08-0831  0.469
2008 Cinelli MA, Morrell A, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors. Journal of Medicinal Chemistry. 51: 4609-19. PMID 18630891 DOI: 10.1021/Jm800259E  0.443
2008 Dexheimer TS, Kozekova A, Rizzo CJ, Stone MP, Pommier Y. The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts. Nucleic Acids Research. 36: 4128-36. PMID 18550580 DOI: 10.1093/nar/gkn334  0.378
2008 Dexheimer TS, Antony S, Marchand C, Pommier Y. Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy. Anti-Cancer Agents in Medicinal Chemistry. 8: 381-9. PMID 18473723 DOI: 10.2174/187152008784220357  0.493
2007 Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A, Bates SE, Pommier Y. Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters. Molecular Cancer Therapeutics. 6: 3229-38. PMID 18089716 DOI: 10.1158/1535-7163.Mct-07-0441  0.421
2007 Morrell A, Placzek M, Parmley S, Antony S, Dexheimer TS, Pommier Y, Cushman M. Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization. Journal of Medicinal Chemistry. 50: 4419-30. PMID 17696418 DOI: 10.1021/Jm070361Q  0.354
2006 Dexheimer TS, Sun D, Hurley LH. Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. Journal of the American Chemical Society. 128: 5404-15. PMID 16620112 DOI: 10.1021/Ja0563861  0.507
2006 Dai J, Dexheimer TS, Chen D, Carver M, Ambrus A, Jones RA, Yang D. An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution. Journal of the American Chemical Society. 128: 1096-8. PMID 16433524 DOI: 10.1021/Ja055636A  0.329
2005 Fellows IM, Schwaebe M, Dexheimer TS, Vankayalapati H, Gleason-Guzman M, Whitten JP, Hurley LH. Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity. Molecular Cancer Therapeutics. 4: 1729-39. PMID 16275994 DOI: 10.1158/1535-7163.Mct-05-0183  0.517
2005 Heald RA, Dexheimer TS, Vankayalapati H, Siddiqui-Jain A, Szabo LZ, Gleason-Guzman MC, Hurley LH. Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones. Journal of Medicinal Chemistry. 48: 2993-3004. PMID 15828838 DOI: 10.1021/Jm049299C  0.598
Low-probability matches (unlikely to be authored by this person)
2019 Weidlich IE, Dexheimer T, Marchand C, Antony S, Pommier Y, Nicklaus MC. Corrigendum to “Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores” [Bioorg. Med. Chem. 18 (2010) 182–189] Bioorganic & Medicinal Chemistry. 18: 2346. PMID 30035524 DOI: 10.1016/j.bmc.2010.02.008  0.281
2017 Benham V, Chakraborty D, Bullard B, Dexheimer TS, Bernard JJ. Abstract 2236: High-throughput screen for chemopreventative agents that influence adipose-tissue driven epithelial neoplastic transformation Cancer Research. 77: 2236-2236. DOI: 10.1158/1538-7445.Am2017-2236  0.242
2019 Kahl D, Hutchings KM, Lisabeth EM, Haak A, Leipprandt JR, Dexheimer TS, Khanna D, Tsou PS, Campbell PL, Fox DA, Wen B, Sun D, Bailie M, Neubig RR, Larsen SD. 5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Reponse Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma. Journal of Medicinal Chemistry. PMID 30951312 DOI: 10.1021/Acs.Jmedchem.8B01772  0.232
2019 Lisabeth EM, Kahl D, Gopallawa I, Haynes SE, Misek SA, Campbell PL, Dexheimer TS, Khanna D, Fox DA, Jin X, Martin BR, Larsen SD, Neubig RR. Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds. Acs Pharmacology & Translational Science. 2: 92-100. PMID 32039344 DOI: 10.1021/acsptsci.8b00048  0.23
2023 Staerz SD, Lisabeth EM, Njomen E, Dexheimer TS, Neubig RR, Tepe JJ. Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators. Acs Omega. 8: 15650-15659. PMID 37151549 DOI: 10.1021/acsomega.3c01158  0.228
2023 Morris J, Kunkel MW, White SL, Wishka DG, Lopez OD, Bowles L, Sellers Brady P, Ramsey P, Grams J, Rohrer T, Martin K, Dexheimer TS, Coussens NP, Evans D, Risbood P, et al. Targeted Investigational Oncology Agents (IOA) in the NCI60: A Phenotypic Systems-Based Resource. Molecular Cancer Therapeutics. PMID 37550087 DOI: 10.1158/1535-7163.MCT-23-0267  0.224
2018 Piegols HJ, Takada M, Parys M, Dexheimer T, Yuzbasiyan-Gurkan V. Investigation of novel chemotherapeutics for feline oral squamous cell carcinoma. Oncotarget. 9: 33098-33109. PMID 30237854 DOI: 10.18632/Oncotarget.26006  0.22
2022 Misek SA, Foda BM, Dexheimer TS, Akram M, Conrad SE, Schmidt JC, Neubig RR, Gallo KA. BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors. Frontiers in Oncology. 12: 766794. PMID 35444937 DOI: 10.3389/fonc.2022.766794  0.219
2022 Scoles DR, Gandelman M, Paul S, Dexheimer T, Dansithong W, Figueroa KP, Pflieger LT, Redlin S, Kales SC, Sun H, Maloney D, Damoiseaux R, Henderson MJ, Simeonov A, Jadhav A, et al. A quantitative high throughput screen identifies compounds that lower expression of the SCA2- and ALS-associated gene ATXN2. The Journal of Biological Chemistry. 102228. PMID 35787375 DOI: 10.1016/j.jbc.2022.102228  0.207
2017 Jones CL, Njomen E, Sjogren B, Dexheimer TS, Tepe JJ. Small molecule enhancement of 20S proteasome activity targets intrinsically disordered proteins. Acs Chemical Biology. PMID 28719185 DOI: 10.1021/Acschembio.7B00489  0.201
2020 Xing J, Shankar R, Drelich A, Paithankar S, Chekalin E, Dexheimer T, Rajasekaran S, Tseng CK, Chen B. Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19. Biorxiv : the Preprint Server For Biology. PMID 32511305 DOI: 10.1101/2020.04.07.030734  0.191
2021 Appleton KM, Palsuledesai CC, Misek SA, Blake M, Zagorski J, Gallo KA, Dexheimer TS, Neubig RR. Inhibition of the Myocardin-Related Transcription Factor Pathway Increases Efficacy of Trametinib in -Mutant Melanoma Cell Lines. Cancers. 13. PMID 33921974 DOI: 10.3390/cancers13092012  0.182
2020 Liu M, Dexheimer T, Sui D, Hovde S, Deng X, Kwok R, Bochar DA, Kuo MH. Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions. Scientific Reports. 10: 16551. PMID 33024171 DOI: 10.1038/s41598-020-73680-2  0.175
2012 Dexheimer T, Nguyen G, Rosenthal A, Bohr V, Harris C, Jadhav A, Gileadi O, Maloney D, Simeonov A, Hickson I. 276 A Small Molecule Inhibitor of the BLM Helicase That Modulates Chromosome Stability in Human Cells European Journal of Cancer. 48: 85. DOI: 10.1016/S0959-8049(12)72074-9  0.171
2019 Benham V, Bullard B, Dexheimer TS, Bernard MP, Neubig RR, Liby KT, Bernard JJ. Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay. Scientific Reports. 9: 10278. PMID 31311976 DOI: 10.1038/s41598-019-46531-y  0.163
2021 Gandelman M, Dansithong W, Kales SC, Paul S, Maag G, Aoyama E, Zakharov A, Rai G, Dexheimer T, Whitehill BM, Sun H, Jadhav A, Simeonov A, Henderson MJ, Huynh DP, et al. The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy. The Journal of Biological Chemistry. 101191. PMID 34520759 DOI: 10.1016/j.jbc.2021.101191  0.14
2016 Foley TL, Dorjsuren D, Dexheimer TS, Burkart MD, Wight WC, Simeonov A. A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays. Journal of Biomolecular Screening. PMID 27269812 DOI: 10.1177/1087057116652895  0.129
2016 Ferland DJ, Darios ES, Neubig RR, Sjögren B, Truong N, Torres R, Dexheimer TS, Thompson JM, Watts SW. Chemerin-induced arterial contraction is Gi- and calcium-dependent. Vascular Pharmacology. PMID 27890480 DOI: 10.1016/j.vph.2016.11.009  0.124
2021 Jia L, Li S, Dai W, Guo L, Xu Z, Scott AM, Zhang Z, Ren J, Zhang Q, Dexheimer TS, Chung-Davidson YW, Neubig RR, Li Q, Li W. Convergent olfactory trace amine-associated receptors detect biogenic polyamines with distinct motifs via a conserved binding site. The Journal of Biological Chemistry. 101268. PMID 34600890 DOI: 10.1016/j.jbc.2021.101268  0.115
2020 Zhang Z, Zhang Q, Dexheimer TS, Ren J, Neubig RR, Li W. Two highly related odorant receptors specifically detect α-bile acid pheromones in sea lamprey (). The Journal of Biological Chemistry. PMID 32636305 DOI: 10.1074/Jbc.Ra119.011532  0.092
2019 Scott AM, Zhang Z, Jia L, Li K, Zhang Q, Dexheimer T, Ellsworth E, Ren J, Chung-Davidson YW, Zu Y, Neubig RR, Li W. Spermine in semen of male sea lamprey acts as a sex pheromone. Plos Biology. 17: e3000332. PMID 31287811 DOI: 10.1371/Journal.Pbio.3000332  0.067
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