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Alexandra Zanin-Zhorov, Ph.D. - Publications

Affiliations: 
2005 Weizmann Institute of Science, Rehovot, Israel 
Area:
Immunology
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30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Nalkurthi C, Schroder WA, Melino M, Irvine KM, Nyuydzefe M, Chen W, Liu J, Teng MWL, Hill GR, Bertolino P, Blazar BR, Miller GC, Clouston AD, Zanin-Zhorov A, MacDonald KPA. ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis. Jhep Reports : Innovation in Hepatology. 4: 100386. PMID 34917911 DOI: 10.1016/j.jhepr.2021.100386  0.319
2021 Zanin-Zhorov A, Blazar BR. ROCK2, a critical regulator of immune modulation and fibrosis has emerged as a therapeutic target in chronic graft-versus-host disease. Clinical Immunology (Orlando, Fla.). 230: 108823. PMID 34400321 DOI: 10.1016/j.clim.2021.108823  0.364
2020 Zanin-Zhorov A, Kumari S, Hippen KL, Merkel SC, MacMillan ML, Blazar BR, Dustin ML. Author Correction: Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity. Scientific Reports. 10: 3317. PMID 32076101 DOI: 10.1038/S41598-020-60485-6  0.369
2019 Jagasia M, Salhotra A, Bachier CR, Essell JH, Weisdorf DJ, Lazaryan A, Zoghi B, Green LS, Schueller O, Zanin-Zhorov A, Weiss JM, Eiznhamer DA, Aggarwal SK, Blazar BR, Lee SJ. KD025-208: A Phase 2a Study of KD025 for Patients with Chronic Graft Versus Host Disease (cGVHD) - Pharmacodynamics (PD) and Updated Results Biology of Blood and Marrow Transplantation. 25: S28-S29. DOI: 10.1016/J.Bbmt.2018.12.100  0.333
2018 Chen W, Nyuydzefe MS, Weiss JM, Zhang J, Waksal SD, Zanin-Zhorov A. ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells. Scientific Reports. 8: 16636. PMID 30413785 DOI: 10.1038/S41598-018-35109-9  0.427
2018 Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR. Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling. The Journal of Clinical Investigation. PMID 29733295 DOI: 10.1172/JCI121856  0.559
2018 Jagasia M, Salhotra A, Bachier CR, Essell J, Weisdorf DJ, Zoghi B, Green LS, Schueller O, Zanin-Zhorov A, Weiss JM, Eiznhamer D, Aggarwal SK, Blazar BR, Lee SJ. KD025-208: A Phase 2a Study of KD025 for Patients with Chronic Graft Versus Host Disease (cGVHD) — Pharmacodynamics and Updated Results Blood. 132: 602-602. DOI: 10.1182/Blood-2018-99-111896  0.377
2017 Zanin-Zhorov A, Kumari S, Hippen KL, Merkel SC, MacMillan ML, Blazar BR, Dustin ML. Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity. Scientific Reports. 7: 4258. PMID 28652577 DOI: 10.1038/S41598-017-04053-5  0.342
2017 Zanin-Zhorov A, Weiss JM, Trzeciak A, Chen W, Zhang J, Nyuydzefe MS, Arencibia C, Polimera S, Schueller O, Fuentes-Duculan J, Bonifacio KM, Kunjravia N, Cueto I, Soung J, Fleischmann RM, et al. Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10. Journal of Immunology (Baltimore, Md. : 1950). PMID 28389592 DOI: 10.4049/Jimmunol.1602142  0.404
2016 Weiss JM, Chen W, Nyuydzefe MS, Trzeciak A, Flynn R, Tonra JR, Marusic S, Blazar BR, Waksal SD, Zanin-Zhorov A. ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings. Science Signaling. 9: ra73. PMID 27436361 DOI: 10.1126/Scisignal.Aad8953  0.564
2016 Zanin-Zhorov A, Flynn R, Waksal SD, Blazar BR. Isoform-specific targeting of ROCK proteins in immune cells. Small Gtpases. 0. PMID 27254302 DOI: 10.1080/21541248.2016.1181698  0.432
2016 Flynn R, Paz K, Du J, Reichenbach DK, Taylor PA, Panoskaltsis-Mortari A, Vulic A, Luznik L, MacDonald KK, Hill GR, Nyuydzefe MS, Weiss JM, Chen W, Trzeciak A, Serody JS, ... ... Zanin-Zhorov A, et al. Targeted Rho-associated kinase 2 (ROCK2) inhibition decreases clinical and immune pathology of murine and human chronic GVHD through Stat3-dependent mechanism. Blood. PMID 26983850 DOI: 10.1182/Blood-2015-10-678706  0.448
2015 Zanin-Zhorov A, Waksal SD. ROCKing cytokine secretion balance in human T cells. Cytokine. 72: 224-5. PMID 25649044 DOI: 10.1016/J.Cyto.2014.12.025  0.527
2014 Zanin-Zhorov A, Weiss JM, Nyuydzefe MS, Chen W, Scher JU, Mo R, Depoil D, Rao N, Liu B, Wei J, Lucas S, Koslow M, Roche M, Schueller O, Weiss S, et al. Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 111: 16814-9. PMID 25385601 DOI: 10.1073/Pnas.1414189111  0.521
2014 Zanin-Zhorov A, Flynn R, Luznik L, Panoskaltsis-Mortari A, Jing D, Goodman K, Weiss J, Nyuydzefe M, Chen W, Serody JS, MacDonald KP, Hill GR, O'Shea J, Roche M, Weiss S, et al. A Selective and Potent Rock 2 Inhibitor (KD025) Decreases Human STAT3-Dependent IL-21 and IL-17 Production and Experimental Chronic Graft-Versus-Host Disease (cGVHD) Blood. 124: 540-540. DOI: 10.1182/Blood.V124.21.540.540  0.478
2013 Zanin-Zhorov A, Cohen IR. Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals. Frontiers in Immunology. 4: 211. PMID 23898332 DOI: 10.3389/Fimmu.2013.00211  0.731
2012 Zanin-Zhorov A, Lin J, Scher J, Kumari S, Blair D, Hippen KL, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML. Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function. Proceedings of the National Academy of Sciences of the United States of America. 109: 1625-30. PMID 22307621 DOI: 10.1073/Pnas.1110120109  0.544
2011 Zanin-Zhorov A, Dustin ML, Blazar BR. PKC-θ function at the immunological synapse: prospects for therapeutic targeting. Trends in Immunology. 32: 358-63. PMID 21733754 DOI: 10.1016/J.It.2011.04.007  0.432
2010 Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML. Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (New York, N.Y.). 328: 372-6. PMID 20339032 DOI: 10.1126/Science.1186068  0.395
2010 Fooksman DR, Vardhana S, Vasiliver-Shamis G, Liese J, Blair DA, Waite J, Sacristán C, Victora GD, Zanin-Zhorov A, Dustin ML. Functional anatomy of T cell activation and synapse formation. Annual Review of Immunology. 28: 79-105. PMID 19968559 DOI: 10.1146/Annurev-Immunol-030409-101308  0.415
2007 Zanin-Zhorov A, Tal-Lapidot G, Cahalon L, Cohen-Sfady M, Pevsner-Fischer M, Lider O, Cohen IR. Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling. Journal of Immunology (Baltimore, Md. : 1950). 179: 41-4. PMID 17579019 DOI: 10.4049/Jimmunol.179.1.41  0.685
2007 Pevsner-Fischer M, Morad V, Cohen-Sfady M, Rousso-Noori L, Zanin-Zhorov A, Cohen S, Cohen IR, Zipori D. Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood. 109: 1422-32. PMID 17038530 DOI: 10.1182/Blood-2006-06-028704  0.649
2006 Nussbaum G, Zanin-Zhorov A, Quintana F, Lider O, Cohen IR. Peptide p277 of HSP60 signals T cells: inhibition of inflammatory chemotaxis. International Immunology. 18: 1413-9. PMID 16893923 DOI: 10.1093/Intimm/Dxl074  0.642
2006 Leiba M, Cahalon L, Shimoni A, Lider O, Zanin-Zhorov A, Hecht I, Sela U, Vlodavsky I, Nagler A. Halofuginone inhibits NF-κB and p38 MAPK in activated T cells Journal of Leukocyte Biology. 80: 399-406. PMID 16769768 DOI: 10.1189/Jlb.0705409  0.509
2006 Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR. Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. The Journal of Clinical Investigation. 116: 2022-32. PMID 16767222 DOI: 10.1172/Jci28423  0.64
2005 Cohen-Sfady M, Nussbaum G, Pevsner-Fischer M, Mor F, Carmi P, Zanin-Zhorov A, Lider O, Cohen IR. Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway. Journal of Immunology (Baltimore, Md. : 1950). 175: 3594-602. PMID 16148103 DOI: 10.4049/Jimmunol.175.6.3594  0.678
2005 Zanin-Zhorov A, Tal G, Shivtiel S, Cohen M, Lapidot T, Nussbaum G, Margalit R, Cohen IR, Lider O. Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammation. Journal of Immunology (Baltimore, Md. : 1950). 175: 276-85. PMID 15972659 DOI: 10.4049/Jimmunol.175.1.276  0.709
2005 Zanin-Zhorov A, Bruck R, Tal G, Oren S, Aeed H, Hershkoviz R, Cohen IR, Lider O. Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines. Journal of Immunology (Baltimore, Md. : 1950). 174: 3227-36. PMID 15749853 DOI: 10.4049/Jimmunol.174.6.3227  0.678
2003 Zanin-Zhorov A, Hershkoviz R, Hecht I, Cahalon L, Lider O. Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 5882-9. PMID 14634098 DOI: 10.4049/Jimmunol.171.11.5882  0.539
2003 Zanin-Zhorov A, Nussbaum G, Franitza S, Cohen IR, Lider O. T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1567-9. PMID 12824285 DOI: 10.1096/Fj.02-1139Fje  0.71
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