| Year |
Citation |
Score |
| 2024 |
Deng Y, Banerjee T, Pal DS, Banerjee P, Zhan H, Borleis J, Igleias PA, Devreotes PN. PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration. Biorxiv : the Preprint Server For Biology. PMID 39314378 DOI: 10.1101/2024.09.15.613115 |
0.302 |
|
| 2024 |
Kuhn J, Banerjee P, Haye A, Robinson DN, Iglesias PA, Devreotes PN. Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity. Biorxiv : the Preprint Server For Biology. PMID 38405988 DOI: 10.1101/2024.02.13.580131 |
0.324 |
|
| 2024 |
Hu M, Li H, Zhu K, Guo L, Zhao M, Zhan H, Devreotes PN, Qing Q. Electric field modulation of ERK dynamics shows dependency on waveform and timing. Scientific Reports. 14: 3167. PMID 38326365 DOI: 10.1038/s41598-024-53018-y |
0.344 |
|
| 2023 |
Pal DS, Lin Y, Zhan H, Banerjee T, Kuhn J, Providence S, Devreotes PN. Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement. Frontiers in Cell and Developmental Biology. 11: 1195806. PMID 37492221 DOI: 10.3389/fcell.2023.1195806 |
0.348 |
|
| 2023 |
Pal DS, Banerjee T, Lin Y, de Trogoff F, Borleis J, Iglesias PA, Devreotes PN. Actuation of single downstream nodes in growth factor network steers immune cell migration. Developmental Cell. PMID 37220748 DOI: 10.1016/j.devcel.2023.04.019 |
0.33 |
|
| 2021 |
Kim JH, Hanlon CD, Vohra S, Devreotes PN, Andrew DJ. Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P to direct migration of Drosophila embryonic germ cells. Cell Reports. 34: 108799. PMID 33657369 DOI: 10.1016/j.celrep.2021.108799 |
0.325 |
|
| 2020 |
Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, Ewald AJ, Devreotes PN. Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. Proceedings of the National Academy of Sciences of the United States of America. PMID 32051246 DOI: 10.1073/Pnas.1917938117 |
0.308 |
|
| 2019 |
Pal DS, Li X, Banerjee T, Miao Y, Devreotes PN. The excitable signal transduction networks: movers and shapers of eukaryotic cell migration. The International Journal of Developmental Biology. 63: 407-416. PMID 31840779 DOI: 10.1387/ijdb.190265pd |
0.317 |
|
| 2018 |
Miyanaga Y, Kamimura Y, Kuwayama H, Devreotes PN, Ueda M. Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis. Biochemical and Biophysical Research Communications. 507: 304-310. PMID 30454895 DOI: 10.1016/j.bbrc.2018.11.029 |
0.35 |
|
| 2018 |
Edwards M, Cai H, Abubaker-Sharif B, Long Y, Lampert TJ, Devreotes PN. Insight from the maximal activation of the signal transduction excitable network in. Proceedings of the National Academy of Sciences of the United States of America. PMID 29602807 DOI: 10.1073/Pnas.1710480115 |
0.342 |
|
| 2017 |
Artemenko Y, Devreotes PN. Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation. Journal of Visualized Experiments : Jove. PMID 29155792 DOI: 10.3791/56411 |
0.305 |
|
| 2017 |
Lampert TJ, Kamprad N, Edwards M, Borleis J, Watson AJ, Tarantola M, Devreotes PN. Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28847951 DOI: 10.1073/Pnas.1616600114 |
0.322 |
|
| 2017 |
Schiapparelli P, Guerrero-Cazares H, Magaña-Maldonado R, Hamilla SM, Ganaha S, Goulin Lippi Fernandes E, Huang CH, Aranda-Espinoza H, Devreotes P, Quinones-Hinojosa A. NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin. Ebiomedicine. PMID 28679472 DOI: 10.1016/J.Ebiom.2017.06.020 |
0.438 |
|
| 2017 |
Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell. 66: 345-357.e6. PMID 28475870 DOI: 10.1016/J.Molcel.2017.03.020 |
0.357 |
|
| 2017 |
Gabelli SB, Chen Z, Jiang H, Dempsey D, Amzel LM, Wolberger C, Devreotes P, Cole P. Regulation of WWP2 ubiquitin ligase Acta Crystallographica Section a Foundations and Advances. 73: C833-C833. DOI: 10.1107/S2053273317087411 |
0.308 |
|
| 2016 |
Artemenko Y, Axiotakis L, Borleis J, Iglesias PA, Devreotes PN. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821730 DOI: 10.1073/pnas.1608767113 |
0.3 |
|
| 2015 |
Devreotes P, Horwitz AR. Signaling networks that regulate cell migration. Cold Spring Harbor Perspectives in Biology. 7: a005959. PMID 26238352 DOI: 10.1101/Cshperspect.A005959 |
0.435 |
|
| 2015 |
Swaney KF, Borleis J, Iglesias PA, Devreotes PN. Novel protein Callipygian defines the back of migrating cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E3845-54. PMID 26130809 DOI: 10.1073/pnas.1509098112 |
0.349 |
|
| 2015 |
Edwards M, Cai H, Devreotes P. Persistent Activation of Signal Transduction Networks Induces a Novel Mechanism of Cell Death Biophysical Journal. 108: 142a. DOI: 10.1016/J.Bpj.2014.11.786 |
0.472 |
|
| 2015 |
Lampert TJ, Devreotes PN. Characterizing New Genes Regulating Cell-Substrate Adhesion to Discover Novel Regulatory Mechanisms of Cell Motility Biophysical Journal. 108: 456a. DOI: 10.1016/J.Bpj.2014.11.2488 |
0.325 |
|
| 2015 |
Miao Y, Inoue T, Devreotes P. Synthetic Manipulation of PIP2 Levels and PIP2-Associated Chemotactic Signaling Dissection in Dictyostelium Biophysical Journal. 108: 257a. DOI: 10.1016/J.Bpj.2014.11.1421 |
0.471 |
|
| 2014 |
Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, et al. A unified nomenclature and amino acid numbering for human PTEN. Science Signaling. 7: pe15. PMID 24985344 DOI: 10.1126/Scisignal.2005560 |
0.319 |
|
| 2014 |
Nguyen HN, Yang JM, Afkari Y, Park BH, Sesaki H, Devreotes PN, Iijima M. Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities. Proceedings of the National Academy of Sciences of the United States of America. 111: E2684-93. PMID 24979808 DOI: 10.1073/Pnas.1409433111 |
0.322 |
|
| 2014 |
Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, Devreotes PN. Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science (New York, N.Y.). 343: 1249531. PMID 24653039 DOI: 10.1126/Science.1249531 |
0.31 |
|
| 2014 |
Nguyen HN, Afkari Y, Senoo H, Sesaki H, Devreotes PN, Iijima M. Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium. Oncogene. 33: 5688-96. PMID 24292679 DOI: 10.1038/Onc.2013.507 |
0.322 |
|
| 2013 |
Huang CH, Tang M, Shi C, Iglesias PA, Devreotes PN. An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nature Cell Biology. 15: 1307-16. PMID 24142103 DOI: 10.1038/ncb2859 |
0.318 |
|
| 2013 |
Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife. 2: e00691. PMID 23853711 DOI: 10.7554/Elife.00691 |
0.434 |
|
| 2013 |
Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P. Author response: Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis Elife. DOI: 10.7554/Elife.00691.027 |
0.38 |
|
| 2012 |
Artemenko Y, Batsios P, Borleis J, Gagnon Z, Lee J, Rohlfs M, Sanséau D, Willard SS, Schleicher M, Devreotes PN. Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proceedings of the National Academy of Sciences of the United States of America. 109: 13632-7. PMID 22847424 DOI: 10.1073/Pnas.1211304109 |
0.409 |
|
| 2012 |
Cai H, Huang CH, Devreotes PN, Iijima M. Analysis of chemotaxis in Dictyostelium. Methods in Molecular Biology (Clifton, N.J.). 757: 451-68. PMID 21909927 DOI: 10.1007/978-1-61779-166-6_26 |
0.323 |
|
| 2011 |
Tang M, Iijima M, Kamimura Y, Chen L, Long Y, Devreotes P. Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Molecular Biology of the Cell. 22: 437-47. PMID 21169559 DOI: 10.1091/Mbc.E10-06-0522 |
0.69 |
|
| 2010 |
Xiong Y, Huang CH, Iglesias PA, Devreotes PN. Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proceedings of the National Academy of Sciences of the United States of America. 107: 17079-86. PMID 20864631 DOI: 10.1073/Pnas.1011271107 |
0.322 |
|
| 2010 |
Cai H, Das S, Kamimura Y, Long Y, Parent CA, Devreotes PN. Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. The Journal of Cell Biology. 190: 233-45. PMID 20660630 DOI: 10.1083/Jcb.201001129 |
0.685 |
|
| 2010 |
Kamimura Y, Devreotes PN. Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. The Journal of Biological Chemistry. 285: 7938-46. PMID 20075071 DOI: 10.1074/jbc.M109.089235 |
0.394 |
|
| 2010 |
Franca-Koh J, Willard SS, Devreotes PN. G-protein signaling in chemotaxis Handbook of Cell Signaling, 2/E. 2: 1705-1712. DOI: 10.1016/B978-0-12-374145-5.00207-2 |
0.326 |
|
| 2009 |
Kamimura Y, Tang M, Devreotes P. Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium. Methods in Molecular Biology (Clifton, N.J.). 571: 255-70. PMID 19763972 DOI: 10.1007/978-1-60761-198-1_17 |
0.382 |
|
| 2008 |
Tang L, Franca-Koh J, Xiong Y, Chen MY, Long Y, Bickford RM, Knecht DA, Iglesias PA, Devreotes PN. tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis. Genes & Development. 22: 2278-90. PMID 18708585 DOI: 10.1101/Gad.1694508 |
0.722 |
|
| 2008 |
Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN. PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Current Biology : Cb. 18: 1034-43. PMID 18635356 DOI: 10.1016/j.cub.2008.06.068 |
0.423 |
|
| 2007 |
Chen L, Iijima M, Tang M, Landree MA, Huang YE, Xiong Y, Iglesias PA, Devreotes PN. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Developmental Cell. 12: 603-14. PMID 17419997 DOI: 10.1016/J.Devcel.2007.03.005 |
0.663 |
|
| 2006 |
Somesh BP, Neffgen C, Iijima M, Devreotes P, Rivero F. Dictyostelium RacH regulates endocytic vesicular trafficking and is required for localization of vacuolin. Traffic (Copenhagen, Denmark). 7: 1194-212. PMID 17004322 DOI: 10.1111/J.1600-0854.2006.00455.X |
0.45 |
|
| 2006 |
Somesh BP, Vlahou G, Iijima M, Insall RH, Devreotes P, Rivero F. RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryotic Cell. 5: 1648-63. PMID 16950926 DOI: 10.1128/Ec.00221-06 |
0.644 |
|
| 2006 |
Janetopoulos C, Devreotes P. Phosphoinositide signaling plays a key role in cytokinesis. The Journal of Cell Biology. 174: 485-90. PMID 16908667 DOI: 10.1083/jcb.200603156 |
0.314 |
|
| 2006 |
Vazquez F, Devreotes P. Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. Cell Cycle (Georgetown, Tex.). 5: 1523-7. PMID 16861931 DOI: 10.4161/Cc.5.14.3005 |
0.357 |
|
| 2006 |
Franca-Koh J, Kamimura Y, Devreotes P. Navigating signaling networks: chemotaxis in Dictyostelium discoideum. Current Opinion in Genetics & Development. 16: 333-8. PMID 16782326 DOI: 10.1016/J.Gde.2006.06.001 |
0.383 |
|
| 2006 |
Matsuoka S, Iijima M, Watanabe TM, Kuwayama H, Yanagida T, Devreotes PN, Ueda M. Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. Journal of Cell Science. 119: 1071-9. PMID 16507590 DOI: 10.1242/jcs.02824 |
0.304 |
|
| 2006 |
Loovers HM, Postma M, Keizer-Gunnink I, Huang YE, Devreotes PN, van Haastert PJ. Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Molecular Biology of the Cell. 17: 1503-13. PMID 16421252 DOI: 10.1091/Mbc.E05-09-0825 |
0.402 |
|
| 2005 |
Janetopoulos C, Borleis J, Vazquez F, Iijima M, Devreotes P. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Developmental Cell. 8: 467-77. PMID 15809030 DOI: 10.1016/J.Devcel.2005.02.010 |
0.473 |
|
| 2004 |
Manahan CL, Iglesias PA, Long Y, Devreotes PN. Chemoattractant signaling in dictyostelium discoideum. Annual Review of Cell and Developmental Biology. 20: 223-53. PMID 15473840 DOI: 10.1146/annurev.cellbio.20.011303.132633 |
0.345 |
|
| 2004 |
Ma L, Janetopoulos C, Yang L, Devreotes PN, Iglesias PA. Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophysical Journal. 87: 3764-74. PMID 15465874 DOI: 10.1529/biophysj.104.045484 |
0.329 |
|
| 2004 |
Franca-Koh J, Devreotes PN. Moving forward: mechanisms of chemoattractant gradient sensing. Physiology (Bethesda, Md.). 19: 300-8. PMID 15381759 DOI: 10.1152/physiol.00017.2004 |
0.309 |
|
| 2004 |
Montell C, Devreotes P. From protein dynamics to animal behavior: new insights into complex cell regulatory mechanisms. Current Opinion in Cell Biology. 16: 115-8. PMID 15196552 DOI: 10.1016/J.Ceb.2004.02.011 |
0.314 |
|
| 2004 |
Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America. 101: 8951-6. PMID 15184679 DOI: 10.1073/pnas.0402152101 |
0.317 |
|
| 2004 |
Hynes TR, Tang L, Mervine SM, Sabo JL, Yost EA, Devreotes PN, Berlot CH. Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targeting. The Journal of Biological Chemistry. 279: 30279-86. PMID 15136579 DOI: 10.1074/Jbc.M401432200 |
0.698 |
|
| 2004 |
Iijima M, Huang YE, Luo HR, Vazquez F, Devreotes PN. Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. The Journal of Biological Chemistry. 279: 16606-13. PMID 14764604 DOI: 10.1074/jbc.M312098200 |
0.346 |
|
| 2003 |
Chen L, Janetopoulos C, Huang YE, Iijima M, Borleis J, Devreotes PN. Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Molecular Biology of the Cell. 14: 5028-37. PMID 14595116 DOI: 10.1091/Mbc.E03-05-0339 |
0.625 |
|
| 2003 |
Luo HR, Huang YE, Chen JC, Saiardi A, Iijima M, Ye K, Huang Y, Nagata E, Devreotes P, Snyder SH. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell. 114: 559-72. PMID 13678580 DOI: 10.1016/S0092-8674(03)00640-8 |
0.428 |
|
| 2003 |
Huang YE, Iijima M, Parent CA, Funamoto S, Firtel RA, Devreotes P. Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Molecular Biology of the Cell. 14: 1913-22. PMID 12802064 DOI: 10.1091/mbc.E02-10-0703 |
0.663 |
|
| 2003 |
Devreotes P, Janetopoulos C. Eukaryotic chemotaxis: distinctions between directional sensing and polarization. The Journal of Biological Chemistry. 278: 20445-8. PMID 12672811 DOI: 10.1074/Jbc.R300010200 |
0.415 |
|
| 2002 |
Pergolizzi B, Peracino B, Silverman J, Ceccarelli A, Noegel A, Devreotes P, Bozzaro S. Temperature-sensitive inhibition of development in Dictyostelium due to a point mutation in the piaA gene. Developmental Biology. 251: 18-26. PMID 12413895 DOI: 10.1006/Dbio.2002.0809 |
0.575 |
|
| 2002 |
Iijima M, Huang YE, Devreotes P. Temporal and spatial regulation of chemotaxis. Developmental Cell. 3: 469-78. PMID 12408799 DOI: 10.1016/S1534-5807(02)00292-7 |
0.457 |
|
| 2002 |
Janetopoulos C, Devreotes P. Monitoring receptor-mediated activation of heterotrimeric G-proteins by fluorescence resonance energy transfer. Methods (San Diego, Calif.). 27: 366-73. PMID 12217653 DOI: 10.1016/S1046-2023(02)00095-6 |
0.383 |
|
| 2002 |
Dormann D, Weijer G, Parent CA, Devreotes PN, Weijer CJ. Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Current Biology : Cb. 12: 1178-88. PMID 12176327 |
0.673 |
|
| 2002 |
Iijima M, Devreotes P. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell. 109: 599-610. PMID 12062103 DOI: 10.1016/S0092-8674(02)00745-6 |
0.474 |
|
| 2002 |
Zhao M, Jin T, McCaig CD, Forrester JV, Devreotes PN. Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis. The Journal of Cell Biology. 157: 921-7. PMID 12045182 DOI: 10.1083/jcb.200112070 |
0.371 |
|
| 2002 |
Bankir L, Ahloulay M, Devreotes PN, Parent CA. Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? American Journal of Physiology. Renal Physiology. 282: F376-92. PMID 11832418 DOI: 10.1152/ajprenal.00202.2001 |
0.639 |
|
| 2002 |
Parent CA, Borleis J, Devreotes PN. Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains. The Journal of Biological Chemistry. 277: 1354-60. PMID 11694527 DOI: 10.1074/jbc.M106430200 |
0.636 |
|
| 2002 |
Zhang N, Long Y, Devreotes PN. Ggamma in dictyostelium: its role in localization of gbetagamma to the membrane is required for chemotaxis in shallow gradients. Molecular Biology of the Cell. 12: 3204-13. PMID 11598203 DOI: 10.1091/MBC.12.10.3204 |
0.406 |
|
| 2001 |
Ueda M, Sako Y, Tanaka T, Devreotes P, Yanagida T. Single-molecule analysis of chemotactic signaling in Dictyostelium cells. Science (New York, N.Y.). 294: 864-7. PMID 11679673 DOI: 10.1126/Science.1063951 |
0.42 |
|
| 2001 |
van Es S, Weening KE, Devreotes PN. The protein kinase YakA regulates g-protein-linked signaling responses during growth and development of Dictyostelium. The Journal of Biological Chemistry. 276: 30761-5. PMID 11410593 DOI: 10.1074/JBC.M103365200 |
0.442 |
|
| 2001 |
Briscoe C, Moniakis J, Kim JY, Brown JM, Hereld D, Devreotes PN, Firtel RA. The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation. Developmental Biology. 233: 225-36. PMID 11319871 DOI: 10.1006/Dbio.2001.0217 |
0.398 |
|
| 2001 |
Janetopoulos C, Jin T, Devreotes P. Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science (New York, N.Y.). 291: 2408-11. PMID 11264536 DOI: 10.1126/Science.1055835 |
0.457 |
|
| 2000 |
Jin T, Zhang N, Long Y, Parent CA, Devreotes PN. Localization of the G protein betagamma complex in living cells during chemotaxis. Science (New York, N.Y.). 287: 1034-6. PMID 10669414 DOI: 10.1126/SCIENCE.287.5455.1034 |
0.38 |
|
| 1999 |
van Es S, Devreotes PN. Molecular basis of localized responses during chemotaxis in amoebae and leukocytes. Cellular and Molecular Life Sciences : Cmls. 55: 1341-51. PMID 10487210 DOI: 10.1007/s000180050374 |
0.362 |
|
| 1999 |
Parent CA, Devreotes PN. A cell's sense of direction. Science (New York, N.Y.). 284: 765-70. PMID 10221901 DOI: 10.1126/science.284.5415.765 |
0.424 |
|
| 1999 |
Xiao Z, Yao Y, Long Y, Devreotes P. Desensitization of G-protein-coupled receptors. agonist-induced phosphorylation of the chemoattractant receptor cAR1 lowers its intrinsic affinity for cAMP. The Journal of Biological Chemistry. 274: 1440-8. PMID 9880518 DOI: 10.1074/Jbc.274.3.1440 |
0.406 |
|
| 1998 |
Vithalani KK, Parent CA, Thorn EM, Penn M, Larochelle DA, Devreotes PN, De Lozanne A. Identification of darlin, a Dictyostelium protein with Armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells. Molecular Biology of the Cell. 9: 3095-106. PMID 9802899 DOI: 10.1091/mbc.9.11.3095 |
0.355 |
|
| 1998 |
Parent CA, Blacklock BJ, Froehlich WM, Murphy DB, Devreotes PN. G protein signaling events are activated at the leading edge of chemotactic cells. Cell. 95: 81-91. PMID 9778249 DOI: 10.1016/S0092-8674(00)81784-5 |
0.426 |
|
| 1998 |
Jin T, Amzel M, Devreotes PN, Wu L. Selection of Gβ subunits with point mutations that fail to activate specific signaling pathways in vivo: Dissecting cellular responses mediated by a heterotrimeric G protein in Dictyostelium discoideum Molecular Biology of the Cell. 9: 2949-2961. PMID 9763454 DOI: 10.1091/mbc.9.10.2949 |
0.404 |
|
| 1998 |
Jin T, Soede RD, Liu J, Kimmel AR, Devreotes PN, Schaap P. Temperature-sensitive Gbeta mutants discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors. The Embo Journal. 17: 5076-84. PMID 9724643 DOI: 10.1093/emboj/17.17.5076 |
0.356 |
|
| 1998 |
Peracino B, Borleis J, Jin T, Westphal M, Schwartz JM, Wu L, Bracco E, Gerisch G, Devreotes P, Bozzaro S. G protein beta subunit-null mutants are impaired in phagocytosis and chemotaxis due to inappropriate regulation of the actin cytoskeleton. The Journal of Cell Biology. 141: 1529-37. PMID 9647646 DOI: 10.1083/jcb.141.7.1529 |
0.374 |
|
| 1998 |
Chen MY, Long Y, Devreotes PN. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes & Development. 11: 3218-31. PMID 9389653 DOI: 10.1101/gad.11.23.3218 |
0.416 |
|
| 1997 |
Kim JY, Soede RD, Schaap P, Valkema R, Borleis JA, Van Haastert PJ, Devreotes PN, Hereld D. Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses. The Journal of Biological Chemistry. 272: 27313-8. PMID 9341180 DOI: 10.1074/jbc.272.43.27313 |
0.342 |
|
| 1997 |
Xiao Z, Zhang N, Murphy DB, Devreotes PN. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. The Journal of Cell Biology. 139: 365-74. PMID 9334341 DOI: 10.1083/jcb.139.2.365 |
0.329 |
|
| 1997 |
Zigmond SH, Joyce M, Borleis J, Bokoch GM, Devreotes PN. Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. The Journal of Cell Biology. 138: 363-74. PMID 9230078 DOI: 10.1083/Jcb.138.2.363 |
0.353 |
|
| 1997 |
Xiao Z, Devreotes PN. Identification of detergent-resistant plasma membrane microdomains in dictyostelium: enrichment of signal transduction proteins. Molecular Biology of the Cell. 8: 855-69. PMID 9168471 DOI: 10.1091/mbc.8.5.855 |
0.328 |
|
| 1997 |
Mann SK, Brown JM, Briscoe C, Parent C, Pitt G, Devreotes PN, Firtel RA. Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium. Developmental Biology. 183: 208-21. PMID 9126295 DOI: 10.1006/Dbio.1996.8499 |
0.393 |
|
| 1997 |
Aubry L, Maeda M, Insall R, Devreotes PN, Firtel RA. The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function. The Journal of Biological Chemistry. 272: 3883-6. PMID 9020088 DOI: 10.1074/Jbc.272.7.3883 |
0.605 |
|
| 1997 |
Milne JL, Caterina MJ, Devreotes PN. Random mutagenesis of the cAMP chemoattractant receptor, cAR1, of Dictyostelium. Evidence for multiple states of activation. The Journal of Biological Chemistry. 272: 2069-76. PMID 8999904 DOI: 10.1074/Jbc.272.4.2069 |
0.4 |
|
| 1997 |
Kim JY, Caterina MJ, Milne JL, Lin KC, Borleis JA, Devreotes PN. Random mutagenesis of the cAMP chemoattractant receptor, cAR1, of Dictyostelium. Mutant classes that cause discrete shifts in agonist affinity and lock the receptor in a novel activational intermediate. The Journal of Biological Chemistry. 272: 2060-8. PMID 8999903 DOI: 10.1074/Jbc.272.4.2060 |
0.352 |
|
| 1997 |
Kim JY, Haastert PV, Devreotes PN. Social senses: G-protein-coupled receptor signaling pathways in Dictyostelium discoideum. Chemistry & Biology. 3: 239-43. PMID 8807851 DOI: 10.1016/S1074-5521(96)90103-9 |
0.313 |
|
| 1997 |
Insall RH, Borleis J, Devreotes PN. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Current Biology : Cb. 6: 719-29. PMID 8793298 DOI: 10.1016/S0960-9822(09)00453-9 |
0.58 |
|
| 1996 |
Chen MY, Insall RH, Devreotes PN. Signaling through chemoattractant receptors in Dictyostelium. Trends in Genetics : Tig. 12: 52-7. PMID 8851971 DOI: 10.1016/0168-9525(96)81400-4 |
0.591 |
|
| 1996 |
Parent CA, Devreotes PN. Molecular genetics of signal transduction in Dictyostelium. Annual Review of Biochemistry. 65: 411-40. PMID 8811185 DOI: 10.1146/annurev.bi.65.070196.002211 |
0.357 |
|
| 1996 |
van Es S, Virdy KJ, Pitt GS, Meima M, Sands TW, Devreotes PN, Cotter DA, Schaap P. Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores. The Journal of Biological Chemistry. 271: 23623-5. PMID 8798577 DOI: 10.1074/jbc.271.39.23623 |
0.383 |
|
| 1996 |
Parent CA, Devreotes PN. Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators. The Journal of Biological Chemistry. 271: 18333-6. PMID 8702473 DOI: 10.1074/jbc.271.31.18333 |
0.346 |
|
| 1996 |
Maeda M, Aubry L, Insall R, Gaskins C, Devreotes PN, Firtel RA. Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins. The Journal of Biological Chemistry. 271: 3351-4. PMID 8631932 DOI: 10.1074/Jbc.271.7.3351 |
0.629 |
|
| 1995 |
Caterina MJ, Hereld D, Devreotes PN. Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues. The Journal of Biological Chemistry. 270: 4418-23. PMID 7876207 DOI: 10.1074/Jbc.270.9.4418 |
0.305 |
|
| 1995 |
Lilly PJ, Devreotes PN. Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes. The Journal of Cell Biology. 129: 1659-65. PMID 7790361 DOI: 10.1083/jcb.129.6.1659 |
0.355 |
|
| 1995 |
Caterina MJ, Devreotes PN, Borleis J, Hereld D. Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G protein-coupled chemoattractant receptor from Dictyostelium. The Journal of Biological Chemistry. 270: 8667-72. PMID 7721769 DOI: 10.1074/Jbc.270.15.8667 |
0.301 |
|
| 1995 |
Milne JL, Wu L, Caterina MJ, Devreotes PN. Seven helix cAMP receptors stimulate Ca2+ entry in the absence of functional G proteins in Dictyostelium. The Journal of Biological Chemistry. 270: 5926-31. PMID 7534302 DOI: 10.1074/Jbc.270.11.5926 |
0.318 |
|
| 1994 |
Devreotes PN. G protein-linked signaling pathways control the developmental program of Dictyostelium. Neuron. 12: 235-41. PMID 8110455 DOI: 10.1016/0896-6273(94)90267-4 |
0.301 |
|
| 1994 |
Insall R, Kuspa A, Lilly PJ, Shaulsky G, Levin LR, Loomis WF, Devreotes P. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium Journal of Cell Biology. 126: 1537-1545. PMID 8089184 DOI: 10.1083/Jcb.126.6.1537 |
0.648 |
|
| 1994 |
Insall RH, Soede RD, Schaap P, Devreotes PN. Two cAMP receptors activate common signaling pathways in Dictyostelium. Molecular Biology of the Cell. 5: 703-11. PMID 7949426 DOI: 10.1091/Mbc.5.6.703 |
0.606 |
|
| 1993 |
Saxe CL, Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR. CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum. Genes & Development. 7: 262-72. PMID 8436297 |
0.305 |
|
| 1993 |
Pitt GS, Brandt R, Lin KC, Devreotes PN, Schaap P. Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). Genes & Development. 7: 2172-80. PMID 8224844 DOI: 10.1101/gad.7.11.2172 |
0.36 |
|
| 1993 |
Pupillo M, Insall R, Pitt GS, Devreotes PN. Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. Molecular Biology of the Cell. 3: 1229-34. PMID 1333842 DOI: 10.1091/Mbc.3.11.1229 |
0.598 |
|
| 1992 |
Pitt GS, Milona N, Borleis J, Lin KC, Reed RR, Devreotes PN. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. Cell. 69: 305-15. PMID 1348970 DOI: 10.1016/0092-8674(92)90411-5 |
0.337 |
|
| 1992 |
Van Haastert PJ, Wang M, Bominaar AA, Devreotes PN, Schaap P. cAMP-induced desensitization of surface cAMP receptors in Dictyostelium: different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor, and reduction of receptor mRNA levels. Molecular Biology of the Cell. 3: 603-12. PMID 1323348 DOI: 10.1091/mbc.3.6.603 |
0.306 |
|
| 1991 |
Sun TJ, Devreotes PN. Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium. Genes & Development. 5: 572-82. PMID 1849108 DOI: 10.1101/gad.5.4.572 |
0.326 |
|
| 1990 |
Gundersen RE, Devreotes PN. In vivo receptor-mediated phosphorylation of a G protein in Dictyostelium Science. 248: 591-593. PMID 2110382 DOI: 10.1126/science.2110382 |
0.416 |
|
| 1989 |
Devreotes P. Dictyostelium discoideum: a model system for cell-cell interactions in development. Science (New York, N.Y.). 245: 1054-8. PMID 2672337 DOI: 10.1126/Science.2672337 |
0.378 |
|
| 1988 |
Lilly P, Klein P, Theibert A, Vaughan R, Pupillo M, Saxe K, Kimmel A, Devreotes PN. Receptor G-Protein Interactions in the Development ofDictyostelium Botanica Acta. 101: 123-127. DOI: 10.1111/J.1438-8677.1988.Tb00022.X |
0.401 |
|
| 1987 |
Devreotes P, Fontana D, Klein P, Sherring J, Theibert A. Chapter 17 Transmembrane Signaling in Dictyostelium Methods in Cell Biology. 28: 299-331. PMID 3037274 DOI: 10.1016/S0091-679X(08)61653-2 |
0.342 |
|
| 1986 |
Reymond CD, Gomer RH, Nellen W, Theibert A, Devreotes P, Firtel RA. Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants Nature. 323: 340-343. PMID 3093890 DOI: 10.1038/323340A0 |
0.343 |
|
| 1986 |
Klein P, Fontana D, Knox B, Theibert A, Devreotes P. cAMP receptors controlling cell-cell interactions in the development of Dictyostelium. Cold Spring Harbor Symposia On Quantitative Biology. 50: 787-99. PMID 3007018 DOI: 10.1101/Sqb.1985.050.01.097 |
0.387 |
|
| 1984 |
Chisholm RL, Fontana D, Theibert A, Lodish HF, Devreotes P. Development of Dictyostelium discoideum: Chemotaxis, Cell-cell Adhesion, and Gene Expression Cold Spring Harbor Monograph Archive. 16: 219-254. DOI: 10.1101/087969172.16.219 |
0.38 |
|
| 1981 |
Tomchik KJ, Devreotes PN. Adenosine 3',5'-monophosphate waves in Dictyostelium discoideum: a demonstration by isotope dilution--fluorography. Science (New York, N.Y.). 212: 443-6. PMID 6259734 DOI: 10.1126/Science.6259734 |
0.347 |
|
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