M Edward Medof - Publications

Affiliations: 
Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Immunology, Molecular Biology

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Paiano J, Harland M, Strainic MG, Nedrud J, Hussain W, Medof ME. Follicular B2 Cell Activation and Class Switch Recombination Depend on Autocrine C3ar1/C5ar1 Signaling in B2 Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 31217324 DOI: 10.4049/Jimmunol.1900276  0.354
2019 Strainic M, Liu J, An F, Bailey E, Esposito A, Hamann J, Heeger PS, Medof ME. CD55 Is Essential for CD103 Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity. The American Journal of Pathology. PMID 31103439 DOI: 10.1016/J.Ajpath.2019.04.008  0.325
2018 A Verghese D, Demir M, Chun N, Fribourg M, Cravedi P, Llaudo I, Woodruff TM, Yadav P, Lira SA, Medof ME, Heeger PS. T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival. Journal of Immunology (Baltimore, Md. : 1950). PMID 29436411 DOI: 10.4049/Jimmunol.1701638  0.311
2017 Flückiger R, Cocuzzi E, Nagaraj RH, Shoham M, Kern TS, Medof ME. DAF in diabetic patients is subject to glycation/inactivation at its active site residues. Molecular Immunology. PMID 28886871 DOI: 10.1016/J.Molimm.2017.06.036  0.389
2013 Karpus ON, Veninga H, Hoek RM, Flierman D, van Buul JD, Vandenakker CC, vanBavel E, Medof ME, van Lier RA, Reedquist KA, Hamann J. Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55. Journal of Immunology (Baltimore, Md. : 1950). 190: 3740-8. PMID 23447688 DOI: 10.4049/Jimmunol.1202192  0.325
2013 Strainic MG, Shevach EM, An F, Lin F, Medof ME. Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells. Nature Immunology. 14: 162-71. PMID 23263555 DOI: 10.1038/Ni.2499  0.309
2011 Veninga H, Hoek RM, de Vos AF, de Bruin AM, An FQ, van der Poll T, van Lier RA, Medof ME, Hamann J. A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense. Plos One. 6: e24431. PMID 21984892 DOI: 10.1371/Journal.Pone.0024431  0.329
2011 Vieyra M, Leisman S, Raedler H, Kwan WH, Yang M, Strainic MG, Medof ME, Heeger PS. Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection. The American Journal of Pathology. 179: 766-74. PMID 21704012 DOI: 10.1016/J.Ajpath.2011.04.038  0.309
2010 Plevka P, Hafenstein S, Harris KG, Cifuente JO, Zhang Y, Bowman VD, Chipman PR, Bator CM, Lin F, Medof ME, Rossmann MG. Interaction of decay-accelerating factor with echovirus 7. Journal of Virology. 84: 12665-74. PMID 20881044 DOI: 10.1128/Jvi.00837-10  0.333
2010 Sakuma M, Morooka T, Wang Y, Shi C, Croce K, Gao H, Strainic M, Medof ME, Simon DI. The intrinsic complement regulator decay-accelerating factor modulates the biological response to vascular injury. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1196-202. PMID 20299685 DOI: 10.1161/Atvbaha.110.205559  0.369
2010 Hoek RM, de Launay D, Kop EN, Yilmaz-Elis AS, Lin F, Reedquist KA, Verbeek JS, Medof ME, Tak PP, Hamann J. Deletion of either CD55 or CD97 ameliorates arthritis in mouse models. Arthritis and Rheumatism. 62: 1036-42. PMID 20131275 DOI: 10.1002/Art.27347  0.307
2008 Pavlov V, Raedler H, Yuan S, Leisman S, Kwan WH, Lalli PN, Medof ME, Heeger PS. Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection. Journal of Immunology (Baltimore, Md. : 1950). 181: 4580-9. PMID 18802060 DOI: 10.4049/Jimmunol.181.7.4580  0.358
2008 Lalli PN, Strainic MG, Yang M, Lin F, Medof ME, Heeger PS. Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood. 112: 1759-66. PMID 18567839 DOI: 10.1182/Blood-2008-04-151068  0.326
2008 Strainic MG, Liu J, Huang D, An F, Lalli PN, Muqim N, Shapiro VS, Dubyak GR, Heeger PS, Medof ME. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity. 28: 425-35. PMID 18328742 DOI: 10.1016/J.Immuni.2008.02.001  0.322
2007 Zhou Y, Gong B, Lin F, Rother RP, Medof ME, Kaminski HJ. Anti-C5 antibody treatment ameliorates weakness in experimentally acquired myasthenia gravis. Journal of Immunology (Baltimore, Md. : 1950). 179: 8562-7. PMID 18056404 DOI: 10.4049/Jimmunol.179.12.8562  0.326
2007 Lalli PN, Strainic MG, Lin F, Medof ME, Heeger PS. Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 production. Journal of Immunology (Baltimore, Md. : 1950). 179: 5793-802. PMID 17947652 DOI: 10.4049/Jimmunol.179.9.5793  0.323
2007 Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG. Interaction of decay-accelerating factor with coxsackievirus B3. Journal of Virology. 81: 12927-35. PMID 17804498 DOI: 10.1128/Jvi.00931-07  0.322
2007 Kuttner-Kondo L, Hourcade DE, Anderson VE, Muqim N, Mitchell L, Soares DC, Barlow PN, Medof ME. Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases. The Journal of Biological Chemistry. 282: 18552-62. PMID 17395591 DOI: 10.1074/Jbc.M611650200  0.801
2007 Kuttner-Kondo L, Hourcade DE, Anderson V, Muqim N, Mitchell L, Moulds J, Soares DC, Barlow PN, Medof ME. Structure-based mapping of DAF's active site residues that decay accelerate the C3 convertases Molecular Immunology. 44: 201. DOI: 10.1016/J.Molimm.2006.07.128  0.767
2007 Kuttner-Kondo L, Muqim N, Crabb JW, Hollyfield JG, Medof ME. Effects on factor H function of polymorphisms linked to age-related macular degeneration Molecular Immunology. 44: 201. DOI: 10.1016/J.Molimm.2006.07.127  0.741
2006 Kaminski HJ, Kusner LL, Richmonds C, Medof ME, Lin F. Deficiency of decay accelerating factor and CD59 leads to crisis in experimental myasthenia. Experimental Neurology. 202: 287-93. PMID 16859686 DOI: 10.1016/J.Expneurol.2006.06.003  0.387
2005 Heeger PS, Lalli PN, Lin F, Valujskikh A, Liu J, Muqim N, Xu Y, Medof ME. Decay-accelerating factor modulates induction of T cell immunity. The Journal of Experimental Medicine. 201: 1523-30. PMID 15883171 DOI: 10.1084/Jem.20041967  0.387
2004 Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguénec C, Lea SM, et al. An atomic resolution model for assembly, architecture, and function of the Dr adhesins. Molecular Cell. 15: 647-57. PMID 15327779 DOI: 10.1016/J.Molcel.2004.08.003  0.36
2004 Lin F, Salant DJ, Meyerson H, Emancipator S, Morgan BP, Medof ME. Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis. Journal of Immunology (Baltimore, Md. : 1950). 172: 2636-42. PMID 14764738 DOI: 10.4049/Jimmunol.172.4.2636  0.314
2003 Kuttner-Kondo LA, Dybvig MP, Mitchell LM, Muqim N, Atkinson JP, Medof ME, Hourcade DE. A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases. The Journal of Biological Chemistry. 278: 52386-91. PMID 14561755 DOI: 10.1074/Jbc.M304620200  0.789
2003 Li R, Liu T, Yoshihiro F, Tary-Lehmann M, Obrenovich M, Kuekrek H, Kang SC, Pan T, Wong BS, Medof ME, Sy MS. On the same cell type GPI-anchored normal cellular prion and DAF protein exhibit different biological properties. Biochemical and Biophysical Research Communications. 303: 446-51. PMID 12659837 DOI: 10.1016/S0006-291X(03)00354-1  0.417
2003 Chen R, Anderson V, Hiroi Y, Medof ME. Proprotein interaction with the GPI transamidase Journal of Cellular Biochemistry. 88: 1025-1037. PMID 12616539 DOI: 10.1002/Jcb.10439  0.35
2002 Uhrínová S, Lin F, Uhrín du U, Medof ME, Barlow PN. Letter to the Editor: Resonance assignments of the central complement control protein module pair of human decay accelerating factor. Journal of Biomolecular Nmr. 23: 167-8. PMID 20859790 DOI: 10.1023/A:1016362923187  0.346
2002 Lin F, Kaminski HJ, Conti-Fine BM, Wang W, Richmonds C, Medof ME. Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection. The Journal of Clinical Investigation. 110: 1269-74. PMID 12417565 DOI: 10.1172/Jci16086  0.343
2002 He Y, Lin F, Chipman PR, Bator CM, Baker TS, Shoham M, Kuhn RJ, Medof ME, Rossmann MG. Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex. Proceedings of the National Academy of Sciences of the United States of America. 99: 10325-9. PMID 12119400 DOI: 10.1073/Pnas.152161599  0.356
2002 De Silva AD, Park JJ, Matsuki N, Stanic AK, Brutkiewicz RR, Medof ME, Joyce S. Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. Journal of Immunology (Baltimore, Md. : 1950). 168: 723-33. PMID 11777966 DOI: 10.4049/Jimmunol.168.2.723  0.328
2002 Hourcade DE, Mitchell L, Kuttner-Kondo LA, Atkinson JP, Medof ME. Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb. The Journal of Biological Chemistry. 277: 1107-12. PMID 11694537 DOI: 10.1074/Jbc.M109322200  0.779
2001 Bardenstein DS, Cheyer CJ, Lee C, Cocuzzi E, Mizuno M, Okada N, Medof ME. Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. Immunology. 104: 423-30. PMID 11899428 DOI: 10.1046/J.1365-2567.2001.01316.X  0.373
2001 Cocuzzi ET, Bardenstein DS, Stavitsky A, Sundarraj N, Medof ME. Upregulation of DAF (CD55) on orbital fibroblasts by cytokines. Differential effects of TNF-beta and TNF-alpha. Current Eye Research. 23: 86-92. PMID 11840345 DOI: 10.1076/Ceyr.23.2.86.5478  0.369
2001 Lin F, Fukuoka Y, Spicer A, Ohta R, Okada N, Harris CL, Emancipator SN, Medof ME. Tissue distribution of products of the mouse decay-accelerating factor (DAF) genes. Exploitation of a Daf1 knock-out mouse and site-specific monoclonal antibodies. Immunology. 104: 215-25. PMID 11683962 DOI: 10.1046/J.1365-2567.2001.01287.X  0.355
2001 Premkumar DR, Fukuoka Y, Sevlever D, Brunschwig E, Rosenberry TL, Tykocinski ML, Medof ME. Properties of exogenously added GPI-anchored proteins following their incorporation into cells. Journal of Cellular Biochemistry. 82: 234-45. PMID 11527149 DOI: 10.1002/Jcb.1154  0.369
2001 Lin F, Immormino RM, Shoham M, Medof ME. Bulk production and functional analyses of mouse CD55's native and deglycosylated active domains. Archives of Biochemistry and Biophysics. 393: 67-72. PMID 11516162 DOI: 10.1006/abbi.2001.2488  0.313
2001 Kuttner-Kondo LA, Mitchell L, Hourcade DE, Medof ME. Characterization of the active sites in decay-accelerating factor. Journal of Immunology (Baltimore, Md. : 1950). 167: 2164-71. PMID 11490001 DOI: 10.4049/Jimmunol.167.4.2164  0.789
2001 Cocuzzi E, Szczotka LB, Brodbeck WG, Bardenstein DS, Wei T, Medof ME. Tears contain the complement regulator CD59 as well as decay-accelerating factor (DAF). Clinical and Experimental Immunology. 123: 188-95. PMID 11207647  0.754
2000 Cocuzzi E, Guidubaldi J, Bardenstein DS, Chen R, Jacobs MR, Medof ME. Release of complement regulatory proteins from ocular surface cells in infections Current Eye Research. 21: 856-866. PMID 11262607 DOI: 10.1076/Ceyr.21.5.856.5539  0.367
2000 Szczotka LB, Cocuzzi E, Medof ME. Decay-accelerating factor in tears of contact lens wearers and patients with contact lens-associated complications. Optometry and Vision Science : Official Publication of the American Academy of Optometry. 77: 586-91. PMID 11138832 DOI: 10.1097/00006324-200011000-00008  0.314
2000 Fayen JD, Tykocinski ML, Medof ME. Glycerolphosphoinositide anchors for membrane-tethering proteins. Methods in Enzymology. 327: 351-68. PMID 11044996 DOI: 10.1016/S0076-6879(00)27289-3  0.341
2000 Brodbeck WG, Mold C, Atkinson JP, Medof ME. Cooperation between decay-accelerating factor and membrane cofactor protein in protecting cells from autologous complement attack. Journal of Immunology (Baltimore, Md. : 1950). 165: 3999-4006. PMID 11034410 DOI: 10.1016/S0162-3109(00)80185-X  0.769
2000 Brodbeck WG, Kuttner-Kondo L, Mold C, Medof ME. Structure/function studies of human decay-accelerating factor. Immunology. 101: 104-11. PMID 11012760 DOI: 10.1046/J.1365-2567.2000.00086.X  0.771
2000 Chen R, Nagarajan S, Prince GM, Maheshwari U, Terstappen LW, Kaplan DR, Gerson SL, Albert JM, Dunn DE, Lazarus HM, Medof ME. Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria. The Journal of Clinical Investigation. 106: 689-96. PMID 10974022 DOI: 10.1172/Jci8328  0.313
2000 Kuttner-Kondo L, Subramanian VB, Atkinson JP, Yu J, Medof ME. Conservation in decay accelerating factor (DAF) structure among primates. Developmental and Comparative Immunology. 24: 815-27. PMID 10906393 DOI: 10.1016/S0145-305X(00)00026-4  0.782
2000 Mitchell L, Kuttner-Kondo L, Medof M, Hourcade D. Identification of a factor B site involved in the dissociation of the AP C3 convertase by decay accelerating factor Immunopharmacology. 49: 64. DOI: 10.1016/S0162-3109(00)80180-0  0.777
2000 Kuttner-Kondo L, Mitchell L, Hourcade D, Medof M. Characterization of the active site in Decay-Accelerating Factor (DAF) Immunopharmacology. 49: 64. DOI: 10.1016/S0162-3109(00)80179-4  0.772
1999 Sevlever D, Pickett S, Mann KJ, Sambamurti K, Medof ME, Rosenberry TL. Glycosylphosphatidylinositol-anchor intermediates associate with triton-insoluble membranes in subcellular compartments that include the endoplasmic reticulum. The Biochemical Journal. 343: 627-35. PMID 10527942 DOI: 10.1042/0264-6021:3430627  0.312
1999 Hourcade DE, Mitchell LM, Medof ME. Decay acceleration of the complement alternative pathway C3 convertase Immunopharmacology. 42: 167-173. PMID 10408377 DOI: 10.1016/S0162-3109(99)00005-3  0.471
1998 Chen R, Walter EI, Parker G, Lapurga JP, Millan JL, Ikehara Y, Udenfriend S, Medof ME. Mammalian glycophosphatidylinositol anchor transfer to proteins and posttransfer deacylation. Proceedings of the National Academy of Sciences of the United States of America. 95: 9512-7. PMID 9689111 DOI: 10.1073/Pnas.95.16.9512  0.379
1998 Hiroi Y, Komuro I, Chen R, Hosoda T, Mizuno T, Kudoh S, Georgescu SP, Medof ME, Yazaki Y. Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins. Febs Letters. 421: 252-8. PMID 9468317 DOI: 10.1016/S0014-5793(97)01576-7  0.349
1998 Kraus D, Medof ME, Mold C. Complementary recognition of alternative pathway activators by decay-accelerating factor and factor H. Infection and Immunity. 66: 399-405. PMID 9453587 DOI: 10.1128/Iai.66.2.399-405.1998  0.392
1997 Hobert ME, Kil SJ, Medof ME, Carlin CR. The cytoplasmic juxtamembrane domain of the epidermal growth factor receptor contains a novel autonomous basolateral sorting determinant. The Journal of Biological Chemistry. 272: 32901-9. PMID 9407068 DOI: 10.1074/Jbc.272.52.32901  0.327
1997 Yu J, Nagarajan S, Knez JJ, Udenfriend S, Chen R, Medof ME. The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase. Proceedings of the National Academy of Sciences of the United States of America. 94: 12580-5. PMID 9356492 DOI: 10.1073/Pnas.94.23.12580  0.394
1997 Brodsky RA, Vala MS, Barber JP, Medof ME, Jones RJ. Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. Proceedings of the National Academy of Sciences of the United States of America. 94: 8756-60. PMID 9238050 DOI: 10.1073/Pnas.94.16.8756  0.336
1997 Brodbeck WG, Medof ME. Use of recombinant DAF proteins to localize the epitopes recognized by monoclonal anti-CD55. Transfusion Clinique Et Biologique : Journal De La SociéTé FrançAise De Transfusion Sanguine. 4: 125-6. PMID 9095517  0.721
1996 Kuttner-Kondo L, Medof ME, Brodbeck W, Shoham M. Molecular modeling and mechanism of action of human decay-accelerating factor. Protein Engineering. 9: 1143-9. PMID 9010927  0.766
1996 Brodbeck WG, Liu D, Sperry J, Mold C, Medof ME. Localization of classical and alternative pathway regulatory activity within the decay-accelerating factor. Journal of Immunology (Baltimore, Md. : 1950). 156: 2528-33. PMID 8786315  0.778
1995 Stafford HA, Nagarajan S, Weinberg JB, Medof ME. PIG-A, DAF and proto-oncogene expression in paroxysmal nocturnal haemoglobinuria-associated acute myelogenous leukaemia blasts. British Journal of Haematology. 89: 72-8. PMID 7530480 DOI: 10.1111/J.1365-2141.1995.Tb08908.X  0.365
1994 Bardenstein DS, Dietz Y, Lass JH, Medof ME. Localization of the complement membrane attack complex inhibitor (CD59) in human conjunctiva and lacrimal gland. Current Eye Research. 13: 851-5. PMID 7536649 DOI: 10.3109/02713689409015085  0.378
1994 Brodsky RA, Jane SM, Vanin EF, Mitsuya H, Peters TR, Shimada T, Medof ME, Nienhuis AW. Purified GPI-anchored CD4DAF as a receptor for HIV-mediated gene transfer. Human Gene Therapy. 5: 1231-9. PMID 7531502 DOI: 10.1089/Hum.1994.5.10-1231  0.332
1990 Mold C, Walter EI, Medof ME. The influence of membrane components on regulation of alternative pathway activation by decay-accelerating factor. Journal of Immunology (Baltimore, Md. : 1950). 145: 3836-41. PMID 1700997  0.306
1988 Tykocinski ML, Shu HK, Ayers DJ, Walter EI, Getty RR, Groger RK, Hauer CA, Medof ME. Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of decay-accelerating factor's mRNA Proceedings of the National Academy of Sciences of the United States of America. 85: 3555-3559. PMID 2453063 DOI: 10.1073/pnas.85.10.3555  0.301
1987 Medof ME, Walter EI, Roberts WL, Haas R, Rosenberry TL. Decay accelerating factor of complement is anchored to cells by a C-terminal glycolipid. Biochemistry. 25: 6740-7. PMID 2432921 DOI: 10.1021/Bi00370A003  0.377
1987 Berger M, Medof ME. Increased expression of complement decay-accelerating factor during activation of human neutrophils. The Journal of Clinical Investigation. 79: 214-20. PMID 2432089 DOI: 10.1172/JCI112786  0.314
1986 Kinoshita T, Medof ME, Nussenzweig V. Endogenous association of decay-accelerating factor (DAF) with C4b and C3b on cell membranes Journal of Immunology. 136: 3390-3395. PMID 2420889  0.353
1985 Mold C, Medof ME. C3 nephritic factor protects bound C3bBb from cleavage by factor I and human erythrocytes Molecular Immunology. 22: 507-512. PMID 3848661 DOI: 10.1016/0161-5890(85)90173-7  0.322
1984 Medof ME, Kinoshita T, Nussenzweig V. Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes Journal of Experimental Medicine. 160: 1558-1578. PMID 6238120 DOI: 10.1084/jem.160.5.1558  0.324
1982 Medof ME, Antel JP, Oger JJ, Prince GM, Arnason BG. Differences in interaction between immune complexes and complement receptors in serum and cerebrospinal fluid. Clinical and Experimental Immunology. 48: 25-36. PMID 7044631  0.428
1981 Antel JP, Medof ME, Oger JJ, Kuo HH, Arnason BG. Generation of suppressor cells by aggregated human globulin. Clinical and Experimental Immunology. 43: 351-6. PMID 6456096  0.451
1980 Latts JR, Antel JP, Levinson DJ, Arnason BG, Medof ME. Histocompatibility antigens and gold toxicity: a preliminary report. Journal of Clinical Pharmacology. 20: 206-9. PMID 7381033 DOI: 10.1002/J.1552-4604.1980.Tb01698.X  0.421
1979 Antel JP, Arnason BG, Medof ME. Suppressor cell function in multiple sclerosis: correlation with clinical disease activity. Annals of Neurology. 5: 338-42. PMID 312620 DOI: 10.1002/Ana.410050406  0.484
1978 Antel JP, Richman DP, Medof ME, Arnason BG. Lymphocyte function and the role of regulator cells in multiple sclerosis. Neurology. 28: 106-10. PMID 309564 DOI: 10.1212/Wnl.28.9_Part_2.106  0.474
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