Sue Biggins - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
Cell Biology, Genetics, Molecular Biology

80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Barrero DJ, Wijeratne SS, Zhao X, Cunningham GF, Yan R, Nelson CR, Arimura Y, Funabiki H, Asbury CL, Yu Z, Subramanian R, Biggins S. Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast. Biorxiv : the Preprint Server For Biology. PMID 38464254 DOI: 10.1101/2024.02.28.582571  0.406
2023 Popchock AR, Larson JD, Dubrulle J, Asbury CL, Biggins S. Direct observation of coordinated assembly of individual native centromeric nucleosomes. The Embo Journal. e114534. PMID 37469281 DOI: 10.15252/embj.2023114534  0.408
2023 Popchock AR, Larson JD, Dubrulle J, Asbury CL, Biggins S. Single molecule visualization of native centromeric nucleosome formation reveals coordinated deposition by kinetochore proteins and centromere DNA sequence. Biorxiv : the Preprint Server For Biology. PMID 36711558 DOI: 10.1101/2023.01.20.524981  0.379
2022 Lee CH, Biggins S. Microtubule integrity regulates budding yeast RAM pathway gene expression. Frontiers in Cell and Developmental Biology. 10: 989820. PMID 36172269 DOI: 10.3389/fcell.2022.989820  0.426
2022 de Regt AK, Clark CJ, Asbury CL, Biggins S. Tension can directly suppress Aurora B kinase-triggered release of kinetochore-microtubule attachments. Nature Communications. 13: 2152. PMID 35443757 DOI: 10.1038/s41467-022-29542-8  0.423
2022 Hedouin S, Logsdon GA, Underwood JG, Biggins S. A transcriptional roadblock protects yeast centromeres. Nucleic Acids Research. PMID 35253883 DOI: 10.1093/nar/gkac117  0.361
2021 Sarangapani KK, Koch LB, Nelson CR, Asbury CL, Biggins S. Kinetochore-bound Mps1 regulates kinetochore-microtubule attachments via Ndc80 phosphorylation. The Journal of Cell Biology. 220. PMID 34647959 DOI: 10.1083/jcb.202106130  0.493
2020 Herman JA, Miller MP, Biggins S. chTOG is a conserved mitotic error correction factor. Elife. 9. PMID 33377866 DOI: 10.7554/eLife.61773  0.532
2020 Gutierrez A, Kim JO, Umbreit NT, Asbury CL, Davis TN, Miller MP, Biggins S. Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments. Current Biology : Cb. PMID 32946748 DOI: 10.1016/J.Cub.2020.08.054  0.574
2020 Chong SY, Cutler S, Lin JJ, Tsai CH, Tsai HK, Biggins S, Tsukiyama T, Lo YC, Kao CF. H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress. Nature Communications. 11: 809. PMID 32041946 DOI: 10.1038/S41467-020-14595-4  0.352
2019 Miller MP, Evans RK, Zelter A, Geyer EA, MacCoss MJ, Rice LM, Davis TN, Asbury CL, Biggins S. Kinetochore-associated Stu2 promotes chromosome biorientation in vivo. Plos Genetics. 15: e1008423. PMID 31584935 DOI: 10.1371/Journal.Pgen.1008423  0.564
2019 Koch LB, Opoku KN, Deng Y, Barber A, Littleton AJ, London N, Biggins S, Asbury CL. Autophosphorylation is sufficient to release Mps1 kinase from native kinetochores. Proceedings of the National Academy of Sciences of the United States of America. PMID 31405987 DOI: 10.1073/Pnas.1901653116  0.558
2019 Leontiou I, London N, May KM, Ma Y, Grzesiak L, Medina-Pritchard B, Amin P, Jeyaprakash AA, Biggins S, Hardwick KG. The Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest. Current Biology : Cb. PMID 31257143 DOI: 10.1016/J.Cub.2019.06.011  0.548
2018 Suzuki A, Gupta A, Long SK, Evans R, Badger BL, Salmon ED, Biggins S, Bloom K. A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation. Current Biology : Cb. PMID 30174190 DOI: 10.1016/J.Cub.2018.08.038  0.572
2018 Lang J, Barber A, Biggins S. An assay for de novo kinetochore assembly reveals a key role for the CENP-T pathway in budding yeast. Elife. 7. PMID 30117803 DOI: 10.7554/Elife.37819  0.548
2018 Geyer EA, Miller MP, Brautigam CA, Biggins S, Rice LM. Design principles of a microtubule polymerase. Elife. 7. PMID 29897335 DOI: 10.7554/Elife.34574  0.345
2018 Gupta A, Evans RK, Koch LB, Littleton AJ, Biggins S. Purification of kinetochores from the budding yeast Saccharomyces cerevisiae. Methods in Cell Biology. 144: 349-370. PMID 29804677 DOI: 10.1016/Bs.Mcb.2018.03.023  0.609
2018 Lang J, Barber A, Biggins S. Author response: An assay for de novo kinetochore assembly reveals a key role for the CENP-T pathway in budding yeast Elife. DOI: 10.7554/Elife.37819.028  0.342
2017 Tubman ES, Biggins S, Odde DJ. Stochastic Modeling Yields a Mechanistic Framework for Spindle Attachment Error Correction in Budding Yeast Mitosis. Cell Systems. PMID 28601560 DOI: 10.1016/J.Cels.2017.05.003  0.504
2017 Opoku KN, Koch L, Biggins S, Asbury CL. What Silences the Spindle Checkpoint? A Single Particle Study Biophysical Journal. 112: 431a. DOI: 10.1016/J.Bpj.2016.11.2304  0.46
2016 Akiyoshi B, Nelson CR, Ranish JA, Biggins S. Corrigendum: Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit. Genes & Development. 30: 2339. PMID 27898395 DOI: 10.1101/Gad.291450.116  0.372
2016 Deyter GM, Hildebrand EM, Barber AD, Biggins S. Histone H4 Facilitates the Proteolysis of the Budding Yeast CENP-ACse4 Centromeric Histone Variant. Genetics. PMID 27794026 DOI: 10.1534/Genetics.116.194027  0.409
2016 Miller MP, Asbury CL, Biggins S. A TOG Protein Confers Tension Sensitivity to Kinetochore-Microtubule Attachments. Cell. 165: 1428-39. PMID 27156448 DOI: 10.1016/J.Cell.2016.04.030  0.543
2016 Hildebrand EM, Biggins S. Regulation of Budding Yeast CENP-A levels Prevents Misincorporation at Promoter Nucleosomes and Transcriptional Defects. Plos Genetics. 12: e1005930. PMID 26982580 DOI: 10.1371/Journal.Pgen.1005930  0.459
2015 Biggins S. Under Tension: Kinetochores and Basic Research. Genetics. 200: 681-2. PMID 26170442 DOI: 10.1534/Genetics.115.178467  0.534
2014 London N, Biggins S. Signalling dynamics in the spindle checkpoint response. Nature Reviews. Molecular Cell Biology. 15: 736-47. PMID 25303117 DOI: 10.1038/Nrm3888  0.448
2014 Umbreit NT, Miller MP, Tien JF, Ortolá JC, Gui L, Lee KK, Biggins S, Asbury CL, Davis TN. Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation. Nature Communications. 5: 4951. PMID 25236177 DOI: 10.1038/Ncomms5951  0.552
2014 Sarangapani KK, Duro E, Deng Y, Alves Fde L, Ye Q, Opoku KN, Ceto S, Rappsilber J, Corbett KD, Biggins S, Marston AL, Asbury CL. Sister kinetochores are mechanically fused during meiosis I in yeast. Science (New York, N.Y.). 346: 248-51. PMID 25213378 DOI: 10.1126/Science.1256729  0.47
2014 Deyter GMR, Biggins S. The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A Genes and Development. 28: 1815-1826. PMID 25128498 DOI: 10.1101/Gad.243113.114  0.488
2014 Driver JW, Powers AF, Sarangapani KK, Biggins S, Asbury CL. Measuring kinetochore-microtubule interaction in vitro. Methods in Enzymology. 540: 321-37. PMID 24630115 DOI: 10.1016/B978-0-12-397924-7.00018-2  0.596
2014 London N, Biggins S. Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint Genes and Development. 28: 140-152. PMID 24402315 DOI: 10.1101/Gad.233700.113  0.627
2014 Sarangapani K, Duro E, Deng Y, Opoku K, de Lima Alves F, Rappsilber J, Ye Q, Corbett K, Biggins S, Marston A, Asbury C. Biophysical Measurements Reveal Fusion of Sister Kinetochores during Meiosis I Biophysical Journal. 106: 167a. DOI: 10.1016/J.Bpj.2013.11.951  0.419
2014 Biggins S, Sarangapani K, Duro E, Deng Y, Opoku K, de Lima Alves F, Rappsilber J, Marston A, Asbury C. Direct Evidence for Sister Kinetochore Fusion in Meiosis I Biophysical Journal. 106: 637a. DOI: 10.1016/J.Bpj.2013.11.3526  0.343
2013 Ng TM, Lenstra TL, Duggan N, Jiang S, Ceto S, Holstege FC, Dai J, Boeke JD, Biggins S. Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast. Genetics. 195: 795-807. PMID 24037263 DOI: 10.1534/Genetics.113.152082  0.784
2013 Biggins S. The composition, functions, and regulation of the budding yeast kinetochore. Genetics. 194: 817-46. PMID 23908374 DOI: 10.1534/Genetics.112.145276  0.598
2013 Akiyoshi B, Nelson CR, Biggins S. The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast Genetics. 194: 785-789. PMID 23636741 DOI: 10.1534/Genetics.113.150839  0.554
2013 Sarangapani KK, Akiyoshi B, Duggan NM, Biggins S, Asbury CL. Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 110: 7282-7. PMID 23589891 DOI: 10.1073/Pnas.1220700110  0.499
2013 Akiyoshi B, Nelson CR, Duggan N, Ceto S, Ranish JA, Biggins S. The Mub1/Ubr2 Ubiquitin Ligase Complex Regulates the Conserved Dsn1 Kinetochore Protein Plos Genetics. 9. PMID 23408894 DOI: 10.1371/Journal.Pgen.1003216  0.542
2013 Sarangapani KK, Akiyoshi B, Duggan NM, Biggins S, Asbury CL. Phosphoregulation of the Ndc80 and Dam1 Subcomplexes Promotes Release of Kinetochores from Dynamic Microtubules via Multiple Mechanisms Biophysical Journal. 104: 149a-150a. DOI: 10.1016/J.Bpj.2012.11.848  0.504
2013 Driver J, Powers A, Sarangapani K, Akiyoshi B, Duggan N, Biggins S, Asbury C. A Single-Molecule Study to Resolve How Kinases Prevent Chromosomal Mis-Segregation Biophysical Journal. 104: 149a. DOI: 10.1016/J.Bpj.2012.11.844  0.59
2012 Gonen S, Akiyoshi B, Iadanza MG, Shi D, Duggan N, Biggins S, Gonen T. The structure of purified kinetochores reveals multiple microtubule-attachment sites. Nature Structural & Molecular Biology. 19: 925-9. PMID 22885327 DOI: 10.1038/Nsmb.2358  0.508
2012 London N, Ceto S, Ranish JA, Biggins S. Phosphoregulation of Spc105 by Mps1 and PP1 regulates Bub1 localization to kinetochores Current Biology. 22: 900-906. PMID 22521787 DOI: 10.1016/J.Cub.2012.03.052  0.665
2012 Akiyoshi B, Biggins S. Reconstituting the kinetochore-microtubule interface: What, why, and how Chromosoma. 121: 235-250. PMID 22289864 DOI: 10.1007/S00412-012-0362-0  0.559
2012 Unnikrishnan A, Akiyoshi B, Biggins S, Tsukiyama T. An efficient purification system for native minichromosome from saccharomyces cerevisiae Methods in Molecular Biology. 833: 115-123. PMID 22183591 DOI: 10.1007/978-1-61779-477-3_8  0.34
2012 Sarangapani K, Akiyoshi B, Arellano-Santoyo H, Driver J, Duggan N, Powers A, Biggins S, Asbury C. Biophysical Study of Native Yeast Kinetochores Indicates Distinct Roles for Phospho-Regulation of Core Microtubule-Binding Subcomplexes Biophysical Journal. 102: 700a-701a. DOI: 10.1016/J.Bpj.2011.11.3803  0.513
2012 Asbury CL, Sarangapani KK, Akiyoshi B, Duggan N, Driver JW, Arellano-Santoyo H, Powers AF, Biggins S. How Kinetochores Promote Accuracy in Mitosis: Tension, Phosphoregulation, and the Chinese ‘Finger Trap’ Effect Biophysical Journal. 102: 222a. DOI: 10.1016/J.Bpj.2011.11.1219  0.576
2010 Akiyoshi B, Sarangapani KK, Powers AF, Nelson CR, Reichow SL, Arellano-Santoyo H, Gonen T, Ranish JA, Asbury CL, Biggins S. Tension directly stabilizes reconstituted kinetochore-microtubule attachments. Nature. 468: 576-9. PMID 21107429 DOI: 10.1038/Nature09594  0.542
2010 Ranjitkar P, Press MO, Yi X, Baker R, MacCoss MJ, Biggins S. An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain Molecular Cell. 40: 455-464. PMID 21070971 DOI: 10.1016/J.Molcel.2010.09.025  0.423
2010 Akiyoshi B, Biggins S. Cdc14-dependent dephosphorylation of a kinetochore protein prior to anaphase in Saccharomyces cerevisiae Genetics. 186: 1487-1491. PMID 20923974 DOI: 10.1534/Genetics.110.123653  0.588
2009 Akiyoshi B, Nelson CR, Ranish JA, Biggins S. Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit Genes and Development. 23: 2887-2899. PMID 19948764 DOI: 10.1101/Gad.1865909  0.621
2009 Akiyoshi B, Nelson CR, Ranish JA, Biggins S. Analysis of Ipl1-mediated phosphorylation of the Ndc80 kinetochore protein in Saccharomyces cerevisiae Genetics. 183: 1591-1595. PMID 19822728 DOI: 10.1534/Genetics.109.109041  0.535
2009 Ng TM, Waples WG, Lavoie BD, Biggins S. Pericentromeric sister chromatid cohesion promotes kinetochore biorientation. Molecular Biology of the Cell. 20: 3818-27. PMID 19605555 DOI: 10.1091/Mbc.E09-04-0330  0.8
2009 Pinsky BA, Nelson CR, Biggins S. Protein Phosphatase 1 Regulates Exit from the Spindle Checkpoint in Budding Yeast Current Biology. 19: 1182-1187. PMID 19592248 DOI: 10.1016/J.Cub.2009.06.043  0.749
2009 Kotwaliwale CV, Biggins S. Post-translational modifications that regulate kinetochore activity The Kinetochore: From Molecular Discoveries to Cancer Therapy. 293-343. DOI: 10.1007/978-0-387-69076-6_10  0.752
2007 Furuyama S, Biggins S. Centromere identity is specified by a single centromeric nucleosome in budding yeast Proceedings of the National Academy of Sciences of the United States of America. 104: 14706-14711. PMID 17804787 DOI: 10.1073/Pnas.0706985104  0.551
2007 Kotwaliwale CV, Frei SB, Stern BM, Biggins S. A Pathway Containing the Ipl1/Aurora Protein Kinase and the Spindle Midzone Protein Ase1 Regulates Yeast Spindle Assembly Developmental Cell. 13: 433-445. PMID 17765685 DOI: 10.1016/J.Devcel.2007.07.003  0.82
2007 Taylor SS, Hardwick KG, Sawin KE, Biggins S, Piatti S, Khodjakov A, Rieder CL, Salmon ED, Musacchio A. Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". Science (New York, N.Y.). 316: 982; author reply 98. PMID 17510347 DOI: 10.1126/Science.1139484  0.464
2007 Collins KA, Camahort R, Seidel C, Gerton JL, Biggins S. The overexpression of a Saccharomyces cerevisiae centromeric histone H3 variant mutant protein leads to a defect in kinetochore biorientation Genetics. 175: 513-525. PMID 17151247 DOI: 10.1534/Genetics.106.064410  0.584
2007 Biggins S, Kotwaliwale C, Pinsky B, Buvelot S. The Ipl1/Aurora Protein Kinase and Glc7 Protein Phosphatase Regulate The Metaphase to Anaphase Transition The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A93-A  0.772
2006 Kotwaliwale C, Biggins S. Microtubule Capture: A Concerted Effort Cell. 127: 1105-1108. PMID 17174890 DOI: 10.1016/J.Cell.2006.11.032  0.771
2006 Norden C, Mendoza M, Dobbelaere J, Kotwaliwale CV, Biggins S, Barral Y. The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage Cell. 125: 85-98. PMID 16615892 DOI: 10.1016/J.Cell.2006.01.045  0.815
2006 Pinsky BA, Kotwaliwale CV, Tatsutani SY, Breed CA, Biggins S. Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/Aurora protein kinase by redistributing Glc7 Molecular and Cellular Biology. 26: 2648-2660. PMID 16537909 DOI: 10.1128/Mcb.26.7.2648-2660.2006  0.803
2006 Pinsky BA, Kung C, Shokat KM, Biggins S. The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nature Cell Biology. 8: 78-83. PMID 16327780 DOI: 10.1038/Ncb1341  0.743
2005 Collins KA, Castillo AR, Tatsutani SY, Biggins S. De novo kinetochore assembly requires the centromeric histone H3 variant. Molecular Biology of the Cell. 16: 5649-60. PMID 16207811 DOI: 10.1091/Mbc.E05-08-0771  0.565
2005 Pinsky BA, Biggins S. The spindle checkpoint: tension versus attachment. Trends in Cell Biology. 15: 486-93. PMID 16084093 DOI: 10.1016/J.Tcb.2005.07.005  0.7
2005 Kamakaka RT, Biggins S. Histone variants: deviants? Genes & Development. 19: 295-310. PMID 15687254 DOI: 10.1101/Gad.1272805  0.352
2004 Collins KA, Furuyama S, Biggins S. Proteolysis contributes to the exclusive centromere localization of the yeast Cse4/CENP-A histone H3 variant. Current Biology : Cb. 14: 1968-72. PMID 15530401 DOI: 10.1016/J.Cub.2004.10.024  0.583
2004 Biggins S. Correcting SYNful attachments. Nature Cell Biology. 6: 181-3. PMID 15039786 DOI: 10.1038/Ncb0304-181  0.584
2003 Pinsky BA, Tatsutani SY, Collins KA, Biggins S. An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Developmental Cell. 5: 735-45. PMID 14602074 DOI: 10.1016/S1534-5807(03)00322-8  0.758
2003 Biggins S, Walczak CE. Captivating capture: how microtubules attach to kinetochores. Current Biology : Cb. 13: R449-60. PMID 12781157 DOI: 10.1016/S0960-9822(03)00369-5  0.534
2003 Buvelot S, Tatsutani SY, Vermaak D, Biggins S. The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly. The Journal of Cell Biology. 160: 329-39. PMID 12566427 DOI: 10.1083/Jcb.200209018  0.648
2002 Pinsky BA, Biggins S. Top-SUMO wrestles centromeric cohesion. Developmental Cell. 3: 4-6. PMID 12110161 DOI: 10.1016/S1534-5807(02)00214-9  0.638
2002 Bhalla N, Biggins S, Murray AW. Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior. Molecular Biology of the Cell. 13: 632-45. PMID 11854418 DOI: 10.1091/Mbc.01-05-0264  0.557
2001 Biggins S, Murray AW. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes & Development. 15: 3118-29. PMID 11731476 DOI: 10.1101/Gad.934801  0.65
1999 Biggins S, Murray AW. Sister chromatid cohesion in mitosis. Current Opinion in Genetics & Development. 9: 230-6. PMID 10322145 DOI: 10.1016/S0959-437X(99)80034-3  0.55
1999 Biggins S, Severin FF, Bhalla N, Sassoon I, Hyman AA, Murray AW. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes & Development. 13: 532-44. PMID 10072382 DOI: 10.1101/Gad.13.5.532  0.663
1998 Biggins S, Murray AW. Sister chromatid cohesion in mitosis. Current Opinion in Cell Biology. 10: 769-75. PMID 9914173 DOI: 10.1016/S0955-0674(98)80120-8  0.58
1998 Sullivan DS, Biggins S, Rose MD. The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity. The Journal of Cell Biology. 143: 751-65. PMID 9813095 DOI: 10.1083/Jcb.143.3.751  0.47
1996 Biggins S, Ivanovska I, Rose MD. Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center. The Journal of Cell Biology. 133: 1331-46. PMID 8682868 DOI: 10.1083/Jcb.133.6.1331  0.37
1994 Biggins S, Rose MD. Direct interaction between yeast spindle pole body components: Kar1p is required for Cdc31p localization to the spindle pole body. The Journal of Cell Biology. 125: 843-52. PMID 8188750 DOI: 10.1083/Jcb.125.4.843  0.318
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