| Year |
Citation |
Score |
| 2023 |
Desai R, Huang L, Gonzalez RS, Muthuswamy SK. Oncogenic GNAS uses PKA-dependent and independent mechanisms to induce cell proliferation in human pancreatic ductal and acinar organoids. Molecular Cancer Research : McR. PMID 38319286 DOI: 10.1158/1541-7786.MCR-23-0199 |
0.382 |
|
| 2023 |
Muthuswamy SK, Brugge JS. Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges. Cold Spring Harbor Perspectives in Medicine. PMID 38110241 DOI: 10.1101/cshperspect.a041661 |
0.316 |
|
| 2023 |
Desai R, Muthuswamy S. Oncogenic GNAS uses PKA-dependent and independent mechanisms to induce cell proliferation in human pancreatic ductal and acinar organoids. Biorxiv : the Preprint Server For Biology. PMID 36789419 DOI: 10.1101/2023.01.16.524220 |
0.359 |
|
| 2023 |
Paul I, Bolzan D, Youssef A, Gagnon KA, Hook H, Karemore G, Oliphant MUJ, Lin W, Liu Q, Phanse S, White C, Padhorny D, Kotelnikov S, Chen CS, Hu P, ... ... Muthuswamy SK, et al. Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Nature Communications. 14: 688. PMID 36755019 DOI: 10.1038/s41467-023-36122-x |
0.313 |
|
| 2022 |
Saito Y, Matsuda S, Ohnishi N, Endo K, Ashitani S, Ohishi M, Ueno A, Tomita M, Ueda K, Soga T, Muthuswamy SK. Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer. Communications Biology. 5: 403. PMID 35501367 DOI: 10.1038/s42003-022-03363-3 |
0.372 |
|
| 2022 |
Gil Del Alcazar CR, Trinh A, Aleckovic M, Rojas Jimenez E, Harper NW, Oliphant MU, Xie S, Krop ED, Lulseged B, Murphy KC, Keenan TE, Van Allen EM, Tolaney SM, Freeman GJ, Dillon DA, ... Muthuswamy SK, et al. Insights into immune escape during tumor evolution and response to immunotherapy using a rat model of breast cancer. Cancer Immunology Research. PMID 35446942 DOI: 10.1158/2326-6066.CIR-21-0804 |
0.327 |
|
| 2020 |
Ferguson FM, Liu Y, Harshbarger W, Huang L, Wang J, Deng X, Capuzzi SJ, Muratov EN, Tropsha A, Muthuswamy S, Westover KD, Gray NS. Synthesis and structure activity relationships of DCLK1 kinase inhibitors based on a 5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one scaffold. Journal of Medicinal Chemistry. PMID 32530623 DOI: 10.1021/Acs.Jmedchem.0C00596 |
0.332 |
|
| 2020 |
Dimitrov-Markov S, Perales-Patón J, Bockorny B, Dopazo A, Muñoz M, Baños N, Bonilla V, Menendez C, Duran Y, Huang L, Perea S, Muthuswamy SK, Al-Shahrour F, Lopez-Casas PP, Hidalgo M. Discovery of new targets to control metastasis in pancreatic cancer by single cell transcriptomics analysis of circulating tumor cells. Molecular Cancer Therapeutics. PMID 32499301 DOI: 10.1158/1535-7163.Mct-19-1166 |
0.492 |
|
| 2020 |
Grossman JE, Huang L, Muthuswamy L, Perea S, Akshinthala D, Gonzalez R, Tsai L, Cohen J, Sawhney M, Pleskow D, Berzin TM, Bockorny B, Bullock A, Schlechter B, Peters MLB, ... ... Muthuswamy SK, et al. Abstract CT119: Organoid sensitivity in pancreatic cancer correlates with clinical response to treatment and reveals utility for reducing toxicity: Preliminary results from the HOPE trial Cancer Research. 80. DOI: 10.1158/1538-7445.Am2020-Ct119 |
0.313 |
|
| 2019 |
Park S, Brugiolo M, Akerman M, Das S, Urbanski L, Geier A, Kesarwani AK, Fan M, Leclair N, Lin KT, Hu L, Hua I, George J, Muthuswamy SK, Krainer AR, et al. Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. Cell Reports. 29: 2672-2688.e7. PMID 31775037 DOI: 10.1016/J.Celrep.2019.10.110 |
0.497 |
|
| 2019 |
Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK. LLGL2 rescues nutrient stress by promoting leucine uptake in ER breast cancer. Nature. PMID 30996345 DOI: 10.1038/S41586-019-1126-2 |
0.476 |
|
| 2019 |
Muse O, Patell R, Peters C, Schulman S, Darzi E, Schuster C, Huang L, Mukherjee S, Muthuswamy S, Zwicker JI, Flaumenhaft RC. The Unfolded Protein Response Causes Prothrombotic Transformation of Pancreatic Cancer Linking Tumor Progression with Cancer-Associated Thrombosis Blood. 134: 632-632. DOI: 10.1182/Blood-2019-123544 |
0.428 |
|
| 2019 |
Monberg ME, Pagan VB, Semaan A, Lee JJ, Guerrero PA, Muthuswamy SK, Maitra A. Abstract A33: Single-cell profiling reveals subclonal vulnerabilities to therapy in patient-derived 2D and organoid models Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A33 |
0.428 |
|
| 2019 |
Bernard V, Lucas FAS, Huang J, Powell RT, Guerrero PA, Semaan A, Stephan CC, Davies P, Varadhachary GR, Katz MH, Taniguchi CM, Alvarez HA, Muthuswamy S, Maitra A. Abstract 1402: Single cell transcriptomic profiling ofex vivotumoroid models reveal therapeutic vulnerabilities of pancreatic ductal adenocarcinoma Cancer Research. 79: 1402-1402. DOI: 10.1158/1538-7445.Am2019-1402 |
0.436 |
|
| 2018 |
Natividad RJ, Lalli ML, Muthuswamy SK, Asthagiri AR. Golgi Stabilization, Not Its Front-Rear Bias, Is Associated with EMT-Enhanced Fibrillar Migration. Biophysical Journal. PMID 30366626 DOI: 10.1016/J.Bpj.2018.10.006 |
0.444 |
|
| 2018 |
Sonzogni O, Haynes J, Seifried LA, Kamel YM, Huang K, BeGora MD, Yeung FA, Robert-Tissot C, Heng YJ, Yuan X, Wulf GM, Kron KJ, Wagenblast E, Lupien M, Kislinger T, ... ... Muthuswamy SK, et al. Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo. Plos Biology. 16: e2004049. PMID 29924804 DOI: 10.1371/Journal.Pbio.2004049 |
0.443 |
|
| 2018 |
Muthuswamy SK. Organoid Models of Cancer Explode with Possibilities. Cell Stem Cell. 22: 290-291. PMID 29499146 DOI: 10.1016/J.Stem.2018.02.010 |
0.34 |
|
| 2018 |
Saito Y, Desai RR, Muthuswamy SK. Reinterpreting Polarity and Cancer: The changing landscape from tumor suppression to tumor promotion. Biochimica Et Biophysica Acta. PMID 29369778 DOI: 10.1016/J.Bbcan.2017.12.001 |
0.491 |
|
| 2017 |
Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, ... ... Muthuswamy SK, et al. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nature Medicine. PMID 28805820 DOI: 10.1038/Nm.4378 |
0.414 |
|
| 2017 |
Milano D, Muthuswamy S, Asthagiri A. Abstract A37: ‘Touch-and-go' behavior of cancer cells in spatially-confined, fiber-like microenvironments Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-A37 |
0.322 |
|
| 2016 |
Milano DF, Natividad RJ, Saito Y, Luo CY, Muthuswamy SK, Asthagiri AR. Positive Quantitative Relationship between EMT and Contact-Initiated Sliding on Fiber-like Tracks. Biophysical Journal. 111: 1569-1574. PMID 27705778 DOI: 10.1016/J.Bpj.2016.08.037 |
0.504 |
|
| 2016 |
Zheng W, Umitsu M, Jagan I, Tran CW, Ishiyama N, BeGora M, Araki K, Ohashi PS, Ikura M, Muthuswamy SK. An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function. Nature Cell Biology. PMID 27694890 DOI: 10.1038/Ncb3413 |
0.346 |
|
| 2016 |
Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK. Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland. Development (Cambridge, England). 143: e1.1. PMID 27381229 DOI: 10.1242/dev.141093 |
0.452 |
|
| 2016 |
Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK. SCRIBBLE is required for pregnancy-induced alveologenesis in the adult mammary gland. Journal of Cell Science. PMID 27179074 DOI: 10.1242/Dev.141093 |
0.663 |
|
| 2016 |
Milano DF, Ngai NA, Muthuswamy SK, Asthagiri AR. Regulators of Metastasis Modulate the Migratory Response to Cell Contact under Spatial Confinement. Biophysical Journal. 110: 1886-95. PMID 27119647 DOI: 10.1016/J.Bpj.2016.02.040 |
0.519 |
|
| 2016 |
Muthuswamy SK. Abstract PR01: Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-Pr01 |
0.423 |
|
| 2016 |
Anczuków O, Das S, Lin K, Wu J, Akerman M, Muthuswamy SK, Krainer AR. Abstract A50: Nonredundant functions of splicing factors in breast-cancer initiation and metastasis Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-A50 |
0.532 |
|
| 2016 |
Huang L, Holtzinger A, Jagan I, Nostro C, Wang R, Muthuswamy L, Arrowsmith C, Cleary S, Schaeffer D, Roehrl M, Ming-Sound T, Gallinger S, Keller G, Muthuswamy S. Abstract B45: Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B45 |
0.421 |
|
| 2015 |
Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, ... ... Muthuswamy SK, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nature Medicine. PMID 26501191 DOI: 10.1038/Nm.3973 |
0.403 |
|
| 2015 |
Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK. A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. The Journal of Biological Chemistry. 290: 9646-59. PMID 25681440 DOI: 10.1074/Jbc.M114.627968 |
0.447 |
|
| 2014 |
Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology. 10: 558-66. PMID 24845231 DOI: 10.1038/Nchembio.1528 |
0.38 |
|
| 2014 |
Feigin ME, Akshinthala SD, Araki K, Rosenberg AZ, Muthuswamy LB, Martin B, Lehmann BD, Berman HK, Pietenpol JA, Cardiff RD, Muthuswamy SK. Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer. Cancer Research. 74: 3180-94. PMID 24662921 DOI: 10.1158/0008-5472.Can-13-3415 |
0.705 |
|
| 2014 |
Feigin ME, Xue B, Hammell MC, Muthuswamy SK. G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. Proceedings of the National Academy of Sciences of the United States of America. 111: 4191-6. PMID 24599592 DOI: 10.1073/Pnas.1320239111 |
0.509 |
|
| 2013 |
Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK. Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nature Cell Biology. 15: 189-200. PMID 23263278 DOI: 10.1038/Ncb2663 |
0.551 |
|
| 2013 |
Wang H, Lacoche S, Huang L, Xue B, Muthuswamy SK. Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly. Proceedings of the National Academy of Sciences of the United States of America. 110: 163-8. PMID 23248267 DOI: 10.1073/Pnas.1201141110 |
0.38 |
|
| 2013 |
Anczukow O, Lin K, Das S, Wu J, Akerman M, Muthuswamy SK, Krainer AR. Abstract A078: Differential functions of splicing factors in breast cancer initiation and metastasis Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A078 |
0.537 |
|
| 2013 |
Anczukow O, Lin K, Akerman M, Das S, Muthuswamy SK, Krainer A. Abstract B53: Differential functions of splicing factors in breast-cancer initiation and metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-B53 |
0.549 |
|
| 2013 |
Xue B, Muthuswamy S. Abstract A58: Loss of Par3 promotes metastasis of ErbB2 transformed mammary epithelial cells by inhibiting E-cadherin adhesion junction maturation Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A58 |
0.557 |
|
| 2013 |
Dave B, Granados S, Mai J, Choi DS, Gao DC, Mitra S, Shen H, Muthuswamy S, Mittal V, Ferrari M, Chang J. Abstract 2712: Identification of tumor initiating genes RPL39 and MLF2 that mediate lung metastasis through nitric oxide signaling and mesenchymal to epithelial transition. Cancer Research. 73: 2712-2712. DOI: 10.1158/1538-7445.Am2013-2712 |
0.456 |
|
| 2013 |
Feigin ME, Xue B, Hammell M, Muthuswamy SK. Abstract A236: The orphan G-protein coupled receptor GPR161 is an oncogene in triple negative breast cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A236 |
0.534 |
|
| 2012 |
Muthuswamy SK. Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports. Genes & Development. 26: 2253-8. PMID 23070811 DOI: 10.1101/Gad.204636.112 |
0.441 |
|
| 2012 |
Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG. The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold. Molecular Cell. 47: 469-83. PMID 22883624 DOI: 10.1016/J.Molcel.2012.06.037 |
0.458 |
|
| 2012 |
Muthuswamy SK, Xue B. Cell polarity as a regulator of cancer cell behavior plasticity. Annual Review of Cell and Developmental Biology. 28: 599-625. PMID 22881459 DOI: 10.1146/Annurev-Cellbio-092910-154244 |
0.474 |
|
| 2012 |
Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK. Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. Molecular and Cellular Biology. 32: 3913-24. PMID 22851698 DOI: 10.1128/Mcb.00068-12 |
0.552 |
|
| 2012 |
Chatterjee S, Seifried L, Feigin ME, Gibbons DL, Scuoppo C, Lin W, Rizvi ZH, Lind E, Dissanayake D, Kurie J, Ohashi P, Muthuswamy SK. Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells. Plos One. 7: e34343. PMID 22529912 DOI: 10.1371/Journal.Pone.0034343 |
0.487 |
|
| 2012 |
Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural & Molecular Biology. 19: 220-8. PMID 22245967 DOI: 10.1038/Nsmb.2207 |
0.704 |
|
| 2012 |
Muthuswamy SK. Abstract SY37-02: Cell polarity proteins and cancer progression Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy37-02 |
0.549 |
|
| 2012 |
Simpson D, Muthuswamy S, Tansey WP. Impact of Epithelial Organization on Myc Expression and Activity--Response Cancer Research. 72: 1036-1036. DOI: 10.1158/0008-5472.Can-11-3509 |
0.321 |
|
| 2011 |
Lin G, Aranda V, Muthuswamy SK, Tonks NK. Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes & Development. 25: 1412-25. PMID 21724833 DOI: 10.1101/Gad.2018911 |
0.516 |
|
| 2011 |
Simpson DR, Yu M, Zheng S, Zhao Z, Muthuswamy SK, Tansey WP. Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Research. 71: 3822-30. PMID 21610111 DOI: 10.1158/0008-5472.Can-10-3782 |
0.475 |
|
| 2011 |
Muthuswamy SK. Trastuzumab resistance: all roads lead to SRC. Nature Medicine. 17: 416-8. PMID 21475230 DOI: 10.1038/Nm0411-416 |
0.418 |
|
| 2011 |
Muthuswamy SK. 3D culture reveals a signaling network. Breast Cancer Research : Bcr. 13: 103. PMID 21349209 DOI: 10.1186/Bcr2800 |
0.41 |
|
| 2011 |
Keyes WM, Pecoraro M, Aranda V, Vernersson-Lindahl E, Li W, Vogel H, Guo X, Garcia EL, Michurina TV, Enikolopov G, Muthuswamy SK, Mills AA. ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell. 8: 164-76. PMID 21295273 DOI: 10.1016/J.Stem.2010.12.009 |
0.416 |
|
| 2011 |
Feigin ME, Rosenberg AZ, Cardiff RD, Muthuswamy SK. Abstract 920: Mislocalization of the polarity protein Scribble promotes tumorigenesis in the mouse mammary gland Cancer Research. 71: 920-920. DOI: 10.1158/1538-7445.Am2011-920 |
0.624 |
|
| 2011 |
Krishnamurthy K, Aranda V, Muthuswamy S. Abstract 4042: Activation of ErbB2 results in decreased Par6-associated aPKC kinase activity Cancer Research. 71: 4042-4042. DOI: 10.1158/1538-7445.Am2011-4042 |
0.549 |
|
| 2011 |
Xue B, Krishnamurthy K, Muthuswamy SK. Abstract 4037: Loss of Par3 induces an epithelial to metastatic-epithelial transition during ErbB2 induced mammary tumor progression Cancer Research. 71: 4037-4037. DOI: 10.1158/1538-7445.Am2011-4037 |
0.573 |
|
| 2011 |
Huang L, Tai E, Muthuswamy SK. Abstract 200: Identification of proteins involved in c-Myc induced mammary epithelia apoptosis in 3D culture system Cancer Research. 71: 200-200. DOI: 10.1158/1538-7445.Am2011-200 |
0.52 |
|
| 2010 |
Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene. 29: 5839-49. PMID 20711231 DOI: 10.1038/Onc.2010.318 |
0.52 |
|
| 2010 |
Cabodi S, Tinnirello A, Bisaro B, Tornillo G, Camacho-Leal MDP, Forni G, Cojoca R, Iezzi M, Amici A, Montani M, Eva A, Di Stefano P, Muthuswamy SK, Tarone G, Turco E, et al. p130Cas is an essential transducer element in ErbB2 transformation Faseb Journal. 24: 3796-3808. PMID 20505116 DOI: 10.1096/Fj.10-157347 |
0.541 |
|
| 2010 |
Ling C, Zuo D, Xue B, Muthuswamy S, Muller WJ. A novel role for 14–3–3σ in regulating epithelial cell polarity Genes & Development. 24: 947-956. PMID 20439433 DOI: 10.1101/Gad.1896810 |
0.494 |
|
| 2010 |
Huang L, Muthuswamy SK. Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Current Opinion in Genetics & Development. 20: 41-50. PMID 20093003 DOI: 10.1016/J.Gde.2009.12.001 |
0.401 |
|
| 2010 |
Lucs AV, Muller WJ, Muthuswamy SK. Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene. 29: 174-87. PMID 19826412 DOI: 10.1038/Onc.2009.312 |
0.739 |
|
| 2010 |
Anczukow O, Rosenberg A, Muthuswamy SK, Krainer AR. Abstract 1: Role of the splicing factor SF2/ASF in mammary epithelial cell transformation Cancer Research. 70: 1-1. DOI: 10.1158/1538-7445.Am10-1 |
0.703 |
|
| 2009 |
Feigin ME, Muthuswamy SK. Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Current Opinion in Cell Biology. 21: 694-700. PMID 19729289 DOI: 10.1016/J.Ceb.2009.07.003 |
0.501 |
|
| 2009 |
Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell. 137: 1047-61. PMID 19524508 DOI: 10.1016/J.Cell.2009.04.013 |
0.459 |
|
| 2009 |
Feigin ME, Muthuswamy SK. ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion. Experimental Cell Research. 315: 707-16. PMID 19022245 DOI: 10.1016/J.Yexcr.2008.10.034 |
0.547 |
|
| 2008 |
Zavadil J, Haley J, Kalluri R, Muthuswamy SK, Thompson E. Epithelial-mesenchymal transition. Cancer Research. 68: 9574-7. PMID 19047131 DOI: 10.1158/0008-5472.Can-08-2316 |
0.362 |
|
| 2008 |
Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK. Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell. 135: 865-78. PMID 19041750 DOI: 10.1016/J.Cell.2008.09.045 |
0.711 |
|
| 2008 |
Aranda V, Nolan ME, Muthuswamy SK. Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene. 27: 6878-6887. PMID 19029931 DOI: 10.1038/Onc.2008.340 |
0.48 |
|
| 2008 |
Nolan ME, Aranda V, Lee S, Lakshmi B, Basu S, Allred DC, Muthuswamy SK. The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Research. 68: 8201-9. PMID 18922891 DOI: 10.1158/0008-5472.Can-07-6567 |
0.59 |
|
| 2008 |
Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK. Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 105: 12463-8. PMID 18719096 DOI: 10.1073/Pnas.0805009105 |
0.526 |
|
| 2008 |
Guix M, Granja Nde M, Meszoely I, Adkins TB, Wieman BM, Frierson KE, Sanchez V, Sanders ME, Grau AM, Mayer IA, Pestano G, Shyr Y, Muthuswamy S, Calvo B, Krontiras H, et al. Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 897-906. PMID 18180460 DOI: 10.1200/Jco.2007.13.5939 |
0.446 |
|
| 2007 |
Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R, Hannon GJ. A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes & Development. 21: 3238-43. PMID 18079172 DOI: 10.1101/Gad.1616307 |
0.334 |
|
| 2007 |
Tonks NK, Muthuswamy SK. A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer. Cancer Cell. 11: 214-6. PMID 17349579 DOI: 10.1016/J.Ccr.2007.02.022 |
0.402 |
|
| 2006 |
Reginato MJ, Muthuswamy SK. Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Journal of Mammary Gland Biology and Neoplasia. 11: 205-11. PMID 17115263 DOI: 10.1007/S10911-006-9030-4 |
0.454 |
|
| 2006 |
Aranda V, Haire T, Nolan ME, Calarco JP, Rosenberg AZ, Fawcett JP, Pawson T, Muthuswamy SK. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nature Cell Biology. 8: 1235-45. PMID 17060907 DOI: 10.1038/Ncb1485 |
0.644 |
|
| 2006 |
Muthuswamy SK. ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. Cell. 126: 443-5. PMID 16901776 DOI: 10.1016/J.Cell.2006.07.020 |
0.342 |
|
| 2006 |
Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell. 10: 25-38. PMID 16843263 DOI: 10.1016/J.Ccr.2006.05.023 |
0.375 |
|
| 2006 |
Zhan L, Xiang B, Muthuswamy SK. Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Research. 66: 5201-8. PMID 16707444 DOI: 10.1158/0008-5472.Can-05-4081 |
0.506 |
|
| 2006 |
Xiang B, Muthuswamy SK. Using three-dimensional acinar structures for molecular and cell biological assays. Methods in Enzymology. 406: 692-701. PMID 16472698 DOI: 10.1016/S0076-6879(06)06054-X |
0.385 |
|
| 2005 |
Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS. Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Molecular and Cellular Biology. 25: 4591-601. PMID 15899862 DOI: 10.1128/Mcb.25.11.4591-4601.2005 |
0.514 |
|
| 2005 |
Muthuswamy S. Regulation of epithelial cell polarity during carcinogenesis Breast Cancer Research. 7: 1-1. DOI: 10.1186/Bcr1062 |
0.533 |
|
| 2004 |
Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, Miranti CK. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Molecular and Cellular Biology. 24: 8586-99. PMID 15367678 DOI: 10.1128/Mcb.24.19.8586-8599.2004 |
0.466 |
|
| 2004 |
Seton-Rogers SE, Lu Y, Hines LM, Koundinya M, LaBaer J, Muthuswamy SK, Brugge JS. Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 1257-62. PMID 14739340 DOI: 10.1073/Pnas.0308090100 |
0.478 |
|
| 2003 |
Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nature Cell Biology. 5: 733-40. PMID 12844146 DOI: 10.1038/Ncb1026 |
0.48 |
|
| 2003 |
Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (San Diego, Calif.). 30: 256-68. PMID 12798140 DOI: 10.1016/S1046-2023(03)00032-X |
0.39 |
|
| 2002 |
Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. 111: 29-40. PMID 12372298 DOI: 10.1016/S0092-8674(02)01001-2 |
0.47 |
|
| 2001 |
Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini Nature Cell Biology. 3: 785-792. PMID 11533657 DOI: 10.1038/Ncb0901-785 |
0.485 |
|
| 1999 |
Muthuswamy SK, Gilman M, Brugge JS. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Molecular and Cellular Biology. 19: 6845-57. PMID 10490623 DOI: 10.1128/Mcb.19.10.6845 |
0.398 |
|
| 1998 |
Webster MA, Hutchinson JN, Rauh MJ, Muthuswamy SK, Anton M, Tortorice CG, Cardiff RD, Graham FL, Hassell JA, Muller WJ. Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Molecular and Cellular Biology. 18: 2344-59. PMID 9528804 DOI: 10.1128/Mcb.18.4.2344 |
0.431 |
|
| 1996 |
Muller WJ, Arteaga CL, Muthuswamy SK, Siegel PM, Webster MA, Cardiff RD, Meise KS, Li F, Halter SA, Coffey RJ. Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Molecular and Cellular Biology. 16: 5726-36. PMID 8816486 DOI: 10.1128/Mcb.16.10.5726 |
0.328 |
|
| 1994 |
Muthuswamy SK, Siegel PM, Dankort DL, Webster MA, Muller WJ. Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Molecular and Cellular Biology. 14: 735-43. PMID 7903421 DOI: 10.1128/Mcb.14.1.735 |
0.396 |
|
| 1994 |
Muthuswamy SK, Muller WJ. Activation of the Src family of tyrosine kinases in mammary tumorigenesis. Advances in Cancer Research. 64: 111-123. PMID 7879656 DOI: 10.1016/S0065-230X(08)60836-2 |
0.399 |
|
| 1994 |
Guy CT, Muthuswamy SK, Cardiff RD, Soriano P, Muller WJ. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes & Development. 8: 23-32. PMID 7507074 DOI: 10.1101/Gad.8.1.23 |
0.341 |
|
| 1992 |
Mymryk JS, Oakes JD, Muthuswamy SK, D'Amico P, Bayley ST, Lee RW. Disruption of the coordinate expression of muscle genes in a transfected BC3H1 myoblast cell line producing a low level of the adenovirus E1A transforming protein. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 70: 1268-76. PMID 1338413 DOI: 10.1139/O92-173 |
0.314 |
|
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