| Year |
Citation |
Score |
| 2024 |
Corbin J, Yu X, Jin J, Cai L, Wang GG. EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth. Oncogene. PMID 39112519 DOI: 10.1038/s41388-024-03119-9 |
0.581 |
|
| 2024 |
Chen X, Guo Y, Zhao T, Lu J, Fang J, Wang Y, Wang GG, Song J. Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction. Nature Communications. 15: 6217. PMID 39043678 DOI: 10.1038/s41467-024-50526-3 |
0.62 |
|
| 2024 |
Lu J, Guo Y, Yin J, Chen J, Wang Y, Wang GG, Song J. Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations. Nature Communications. 15: 3111. PMID 38600075 DOI: 10.1038/s41467-024-47398-y |
0.572 |
|
| 2023 |
Guo Y, Yu Y, Wang GG. Polycomb Repressive Complex 2 in Oncology. Cancer Treatment and Research. 190: 273-320. PMID 38113005 DOI: 10.1007/978-3-031-45654-1_9 |
0.657 |
|
| 2023 |
Yu X, Li D, Kottur J, Kim HS, Herring LE, Yu Y, Xie L, Hu X, Chen X, Cai L, Liu J, Aggarwal AK, Wang GG, Jin J. Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. Journal of Medicinal Chemistry. PMID 38019706 DOI: 10.1021/acs.jmedchem.3c01521 |
0.571 |
|
| 2023 |
Zhao S, Lu J, Pan B, Fan H, Byrum SD, Xu C, Kim A, Guo Y, Kanchi KL, Gong W, Sun T, Storey AJ, Burkholder NT, Mackintosh SG, Kuhlers PC, ... Wang GG, et al. TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature. PMID 37938770 DOI: 10.1038/s41586-023-06688-z |
0.727 |
|
| 2023 |
Dardis GJ, Wang J, Simon JM, Wang GG, Baldwin AS. An EZH2-NF-κB regulatory axis drives expression of pro-oncogenic gene signatures in triple negative breast cancer. Iscience. 26: 107115. PMID 37416481 DOI: 10.1016/j.isci.2023.107115 |
0.591 |
|
| 2023 |
Xu C, Kim A, Corbin JM, Wang GG. Onco-condensates: formation, multi-component organization, and biological functions. Trends in Cancer. PMID 37349246 DOI: 10.1016/j.trecan.2023.05.006 |
0.57 |
|
| 2023 |
Hanley RP, Nie DY, Tabor JR, Li F, Sobh A, Xu C, Barker NK, Dilworth D, Hajian T, Gibson E, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Herring LE, Wang GG, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. Journal of the American Chemical Society. PMID 36976643 DOI: 10.1021/jacs.3c01421 |
0.641 |
|
| 2023 |
Chi P, Lewis PW, Lu C, Lu J, Ruthenburg AJ, Sabari BR, Shechter D, Wan L, Wang GG. Charles David Allis (1951-2023). Nature Genetics. PMID 36849658 DOI: 10.1038/s41588-023-01331-z |
0.713 |
|
| 2023 |
Cai L, Wang GG. Through the lens of phase separation: intrinsically unstructured protein and chromatin looping. Nucleus (Austin, Tex.). 14: 2179766. PMID 36821650 DOI: 10.1080/19491034.2023.2179766 |
0.595 |
|
| 2023 |
Yu X, Wang J, Gong W, Ma A, Shen Y, Zhang C, Liu X, Cai L, Liu J, Wang GG, Jin J. Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene. PMID 36747009 DOI: 10.1038/s41388-023-02618-5 |
0.593 |
|
| 2023 |
Park KS, Qin L, Kabir M, Luo K, Dale B, Zhong Y, Kim A, Wang GG, Kaniskan HÜ, Jin J. Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2205573. PMID 36737841 DOI: 10.1002/advs.202205573 |
0.593 |
|
| 2022 |
Franklin DA, Liu S, Jin A, Cui P, Guo Z, Arend KC, Moorman NJ, He S, Wang GG, Wan YY, Zhang Y. Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway. The Journal of Biological Chemistry. 102739. PMID 36435197 DOI: 10.1016/j.jbc.2022.102739 |
0.531 |
|
| 2022 |
Liu X, Wang J, Boyer JA, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Rodriguez J, Li M, Uryu H, Liao C, Hu L, ... Wang GG, et al. Histone H3 proline 16 hydroxylation regulates mammalian gene expression. Nature Genetics. PMID 36347944 DOI: 10.1038/s41588-022-01212-x |
0.742 |
|
| 2022 |
Wang J, Park KS, Yu X, Gong W, Earp HS, Wang GG, Jin J, Cai L. A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation. Nucleic Acids Research. PMID 36300627 DOI: 10.1093/nar/gkac861 |
0.563 |
|
| 2022 |
Guo Y, Wang GG. Modulation of the high-order chromatin structure by Polycomb complexes. Frontiers in Cell and Developmental Biology. 10: 1021658. PMID 36274840 DOI: 10.3389/fcell.2022.1021658 |
0.609 |
|
| 2022 |
Meng F, Xu C, Park KS, Kaniskan HÜ, Wang GG, Jin J. Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos. Journal of Medicinal Chemistry. PMID 35895319 DOI: 10.1021/acs.jmedchem.2c00807 |
0.535 |
|
| 2022 |
Gao L, Guo Y, Biswal M, Lu J, Yin J, Fang J, Chen X, Shao Z, Huang M, Wang Y, Wang GG, Song J. Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nature Communications. 13: 4249. PMID 35869095 DOI: 10.1038/s41467-022-31933-w |
0.59 |
|
| 2022 |
Herek TA, Bouska A, Lone WG, Sharma S, Amador C, Heavican-Foral TB, Li Y, Wei Q, Jochum D, Greiner TC, Smith LM, Pileri SA, Feldman A, Rosenwald A, Ott G, ... Wang G, et al. DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T-cells in PTCL-NOS. Blood. PMID 35639959 DOI: 10.1182/blood.2021015019 |
0.546 |
|
| 2022 |
Li D, Yu X, Kottur J, Gong W, Zhang Z, Storey AJ, Tsai YH, Uryu H, Shen Y, Byrum SD, Edmondson RD, Mackintosh SG, Cai L, Liu Z, Aggarwal AK, ... Wang GG, et al. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. PMID 35525905 DOI: 10.1038/s41388-022-02340-8 |
0.567 |
|
| 2022 |
Quiroga IY, Ahn JH, Wang GG, Phanstiel D. Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer. Current Opinion in Genetics & Development. 74: 101901. PMID 35427897 DOI: 10.1016/j.gde.2022.101901 |
0.569 |
|
| 2022 |
Phanstiel DH, Wang GG. Cell type-specific chromatin topology and gene regulation. Trends in Genetics : Tig. PMID 35221113 DOI: 10.1016/j.tig.2022.02.008 |
0.601 |
|
| 2022 |
Ren Z, Kim A, Huang YT, Pi WC, Gong W, Yu X, Qi J, Jin J, Cai L, Roeder RG, Chen WY, Wang GG. A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35217626 DOI: 10.1073/pnas.2122940119 |
0.623 |
|
| 2022 |
Wang J, Yu X, Gong W, Liu X, Park KS, Ma A, Tsai YH, Shen Y, Onikubo T, Pi WC, Allison DF, Liu J, Chen WY, Cai L, Roeder RG, ... Wang GG, et al. EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. Nature Cell Biology. PMID 35210568 DOI: 10.1038/s41556-022-00850-x |
0.614 |
|
| 2022 |
Spangler CJ, Yadav SP, Li D, Geil CN, Smith CB, Wang GG, Lee TH, McGinty RK. DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding. Cell Reports. 38: 110369. PMID 35172132 DOI: 10.1016/j.celrep.2022.110369 |
0.647 |
|
| 2021 |
Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, ... Wang GG, et al. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chemical Biology. PMID 34715055 DOI: 10.1016/j.chembiol.2021.10.003 |
0.624 |
|
| 2021 |
Yu X, Li D, Kottur J, Shen Y, Kim HS, Park KS, Tsai YH, Gong W, Wang J, Suzuki K, Parker J, Herring L, Kaniskan HÜ, Cai L, Jain R, ... Wang GG, et al. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Science Translational Medicine. 13: eabj1578. PMID 34586829 DOI: 10.1126/scitranslmed.abj1578 |
0.488 |
|
| 2021 |
Wei J, Meng F, Park KS, Yim H, Velez J, Kumar P, Wang L, Xie L, Chen H, Shen Y, Teichman E, Li D, Wang GG, Chen X, Kaniskan HÜ, et al. Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. Journal of the American Chemical Society. PMID 34520194 DOI: 10.1021/jacs.1c04841 |
0.529 |
|
| 2021 |
Xu C, Meng F, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HÜ, ... Wang GG, et al. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell Chemical Biology. PMID 34469831 DOI: 10.1016/j.chembiol.2021.08.004 |
0.582 |
|
| 2021 |
Kim A, Wang GG. R-loop and its functions at the regulatory interfaces between transcription and (epi)genome. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. 194750. PMID 34461314 DOI: 10.1016/j.bbagrm.2021.194750 |
0.52 |
|
| 2021 |
Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, Mackintosh SG, Edmondson RD, Byrum SD, Cai L, Tackett AJ, ... Wang GG, et al. Phase separation drives aberrant chromatin looping and cancer development. Nature. PMID 34163069 DOI: 10.1038/s41586-021-03662-5 |
0.622 |
|
| 2021 |
Zhao S, Allis CD, Wang GG. The language of chromatin modification in human cancers. Nature Reviews. Cancer. PMID 34002060 DOI: 10.1038/s41568-021-00357-x |
0.695 |
|
| 2021 |
Ren W, Fan H, Grimm SA, Kim JJ, Li L, Guo Y, Petell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Kim DI, Gao L, Cai L, Khudaverdyan N, ... Wang GG, et al. DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation. Nature Communications. 12: 2490. PMID 33941775 DOI: 10.1038/s41467-021-22665-4 |
0.705 |
|
| 2021 |
Xu C, Tsai YH, Galbo PM, Gong W, Storey AJ, Xu Y, Byrum SD, Xu L, Whang YE, Parker JS, Mackintosh SG, Edmondson RD, Tackett AJ, Huang J, Zheng D, ... Wang GG, et al. Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic Acids Research. PMID 33849067 DOI: 10.1093/nar/gkab252 |
0.539 |
|
| 2021 |
Fan H, Guo Y, Tsai YH, Storey AJ, Kim A, Gong W, Edmondson RD, Mackintosh SG, Li H, Byrum SD, Tackett AJ, Cai L, Wang GG. A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic Acids Research. PMID 33823544 DOI: 10.1093/nar/gkab210 |
0.664 |
|
| 2021 |
Li J, Galbo PM, Gong W, Storey AJ, Tsai YH, Yu X, Ahn JH, Guo Y, Mackintosh SG, Edmondson RD, Byrum SD, Farrar JE, He S, Cai L, Jin J, ... Wang GG, et al. ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nature Communications. 12: 1045. PMID 33594072 DOI: 10.1038/s41467-021-21357-3 |
0.669 |
|
| 2021 |
Guo Y, Zhao S, Wang GG. Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction. Trends in Genetics : Tig. PMID 33494958 DOI: 10.1016/j.tig.2020.12.006 |
0.651 |
|
| 2020 |
Wang J, Wang GG. No Easy Way Out for EZH2: Its Pleiotropic, Noncanonical Effects on Gene Regulation and Cellular Function. International Journal of Molecular Sciences. 21. PMID 33327550 DOI: 10.3390/ijms21249501 |
0.657 |
|
| 2020 |
Fan H, Lu J, Guo Y, Li D, Zhang ZM, Tsai YH, Pi WC, Ahn JH, Gong W, Xiang Y, Allison DF, Geng H, He S, Diao Y, Chen WY, ... Wang GG, et al. BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nature Genetics. PMID 33139953 DOI: 10.1038/s41588-020-00729-3 |
0.747 |
|
| 2020 |
Koss B, Shields BD, Taylor EM, Storey AJ, Byrum SD, Gies AJ, Washam CL, Roy Choudhury S, Hyun Ahn J, Uryu H, Williams JB, Krager KJ, Chiang TC, Mackintosh SG, Edmondson RD, ... Wang GG, et al. Epigenetic control of Cdkn2a.Arf protects tumor-infiltrating lymphocytes from metabolic exhaustion. Cancer Research. PMID 33004350 DOI: 10.1158/0008-5472.CAN-20-0524 |
0.53 |
|
| 2020 |
Ren W, Fan H, Grimm SA, Guo Y, Kim JJ, Yin J, Li L, Petell CJ, Tan XF, Zhang ZM, Coan JP, Gao L, Cai L, Detrick B, Çetin B, ... ... Wang GG, et al. Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32675241 DOI: 10.1073/Pnas.2009316117 |
0.72 |
|
| 2020 |
Gao L, Emperle M, Guo Y, Grimm SA, Ren W, Adam S, Uryu H, Zhang ZM, Chen D, Yin J, Dukatz M, Anteneh H, Jurkowska RZ, Lu J, Wang Y, ... ... Wang GG, et al. Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nature Communications. 11: 3355. PMID 32620778 DOI: 10.1038/S41467-020-17109-4 |
0.59 |
|
| 2020 |
Zhang Y, Guo Y, Gough SM, Zhang J, Vann KR, Li K, Cai L, Shi X, Aplan PD, Wang GG, Kutateladze TG. Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nature Communications. 11: 3339. PMID 32620764 DOI: 10.1038/S41467-020-17098-4 |
0.625 |
|
| 2020 |
Pi WC, Wang J, Shimada M, Lin JW, Geng H, Lee YL, Li D, Wang GG, Roeder RG, Chen WY. E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia. Blood. PMID 32276273 DOI: 10.1182/blood.2019003312 |
0.621 |
|
| 2019 |
De Silva D, Zhang Z, Liu Y, Parker JS, Xu C, Cai L, Wang GG, Earp HS, Whang YE. Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. Scientific Reports. 9: 18637. PMID 31819114 DOI: 10.1038/S41598-019-55057-2 |
0.566 |
|
| 2019 |
Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, ... ... Wang GG, et al. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chemical Biology. PMID 31422906 DOI: 10.1016/J.Chembiol.2019.07.013 |
0.639 |
|
| 2019 |
Ren Z, Ahn JH, Liu H, Tsai YH, Bhanu NV, Koss B, Allison DF, Ma A, Storey AJ, Wang P, Mackintosh SG, Edmondson RD, Groen RWJ, Martens AC, Garcia BA, ... ... Wang GG, et al. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation. Blood. PMID 31383640 DOI: 10.1182/Blood.2019000578 |
0.621 |
|
| 2019 |
Allison DF, Wang GG. R-loops: formation, function, and relevance to cell stress. Cell Stress. 3: 38-46. PMID 31225499 DOI: 10.15698/cst2019.02.175 |
0.556 |
|
| 2019 |
Lu R, Wang J, Ren Z, Yin J, Wang Y, Cai L, Wang GG. A model system for studying the DNMT3A hotspot mutation (DNMT3AR882) demonstrates a causal relationship between its dominant-negative effect and leukemogenesis. Cancer Research. PMID 31164355 DOI: 10.1158/0008-5472.Can-18-3275 |
0.604 |
|
| 2019 |
Li J, Ahn JH, Wang GG. Understanding histone H3 lysine 36 methylation and its deregulation in disease. Cellular and Molecular Life Sciences : Cmls. PMID 31147750 DOI: 10.1007/s00018-019-03144-y |
0.629 |
|
| 2019 |
Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, ... ... Wang GG, et al. BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. 35: 752-766.e9. PMID 31085176 DOI: 10.1016/J.Ccell.2019.04.005 |
0.533 |
|
| 2018 |
Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS, ... Wang GG, et al. ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. Molecular Cell. PMID 30270106 DOI: 10.1016/J.Molcel.2018.08.029 |
0.539 |
|
| 2018 |
Wang G, Biswas AK, Ma W, Kandpal M, Coker C, Grandgenett PM, Hollingsworth MA, Jain R, Tanji K, Lόpez-Pintado S, Borczuk A, Hebert D, Jenkitkasemwong S, Hojyo S, Davuluri RV, et al. Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle. Nature Medicine. 24: 770-781. PMID 29875463 DOI: 10.1038/S41591-018-0054-2 |
0.502 |
|
| 2018 |
Xu B, Cai L, Butler JM, Chen D, Lu X, Allison DF, Lu R, Rafii S, Parker JS, Zheng D, Wang GG. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports. PMID 29456179 DOI: 10.1016/J.Stemcr.2018.01.020 |
0.597 |
|
| 2018 |
Zhang ZM, Lu R, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG, Song J. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature. PMID 29414941 DOI: 10.1038/Nature25477 |
0.606 |
|
| 2017 |
Lu R, Wang GG. Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia. Frontiers in Oncology. 7: 241. PMID 29075615 DOI: 10.3389/fonc.2017.00241 |
0.637 |
|
| 2016 |
Lu R, Wang GG. Gene enhancer deregulation and epigenetic vulnerability. Oncoscience. 3: 299-301. PMID 28105447 DOI: 10.18632/oncoscience.334 |
0.581 |
|
| 2016 |
Wu B, Wang Y, Wang C, Wang GG, Wu J, Wan YY. BPTF Is Essential for T Cell Homeostasis and Function. Journal of Immunology (Baltimore, Md. : 1950). PMID 27799308 DOI: 10.4049/jimmunol.1600642 |
0.56 |
|
| 2016 |
Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen WY, Abdel-Wahab O, Wade PA, Zheng D, Wang GG. Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development. Cancer Cell. PMID 27344947 DOI: 10.1016/J.Ccell.2016.05.008 |
0.618 |
|
| 2016 |
Li Z, Chen P, Su R, Hu C, Li Y, Elkahloun AG, Zuo Z, Gurbuxani S, Arnovitz S, Weng H, Wang Y, Li S, Huang H, Neilly MB, Wang GG, et al. PBX3 and MEIS1 cooperate in hematopoietic cells to drive acute myeloid leukemias characterized by a core transcriptome of the MLL-rearranged disease. Cancer Research. PMID 26747896 DOI: 10.1158/0008-5472.Can-15-1566 |
0.619 |
|
| 2016 |
Zhang Z, Rothbart SB, Allison DF, Harrison JS, Wang Y, Strahl BD, Wang GG, Song J. Allosteric Regulation of UHRF1 for DNA Methylation Maintenance Biophysical Journal. 110: 513a. DOI: 10.1016/J.Bpj.2015.11.2742 |
0.728 |
|
| 2015 |
Zhang ZM, Rothbart SB, Allison DF, Cai Q, Harrison JS, Li L, Wang Y, Strahl BD, Wang GG, Song J. An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Reports. 12: 1400-6. PMID 26299963 DOI: 10.1016/J.Celrep.2015.07.046 |
0.701 |
|
| 2015 |
Xu B, Konze KD, Jin J, Wang GG. Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Experimental Hematology. PMID 26027790 DOI: 10.1016/j.exphem.2015.05.001 |
0.64 |
|
| 2015 |
Gong H, Qian H, Ertl R, Astle CM, Wang GG, Harrison DE, Xu X. Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain. Oncotarget. PMID 26021816 |
0.533 |
|
| 2015 |
Wang GG, Konze KD, Tao J. Polycomb genes, miRNA, and their deregulation in B-cell malignancies. Blood. 125: 1217-25. PMID 25568352 DOI: 10.1182/blood-2014-10-606822 |
0.488 |
|
| 2015 |
Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, ... ... Wang GG, et al. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 125: 346-57. PMID 25395428 DOI: 10.1182/Blood-2014-06-581082 |
0.622 |
|
| 2015 |
Lu R, Wang P, Parton T, Zheng D, Wang GG. Epigenetic Reprogramming of Cis-Regulatory Sites By R882-Mutated DNMT3A Potentiates Aberrant Stem Cell Gene Program and Acute Leukemia Development Blood. 126: 2430-2430. DOI: 10.1182/Blood.V126.23.2430.2430 |
0.604 |
|
| 2014 |
Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, et al. NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function. Cancer Discovery. 4: 564-77. PMID 24535671 DOI: 10.1158/2159-8290.Cd-13-0419 |
0.595 |
|
| 2013 |
Lu R, Wang GG. Tudor: a versatile family of histone methylation 'readers'. Trends in Biochemical Sciences. 38: 546-55. PMID 24035451 DOI: 10.1016/j.tibs.2013.08.002 |
0.616 |
|
| 2013 |
Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, ... ... Wang GG, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. Acs Chemical Biology. 8: 1324-34. PMID 23614352 DOI: 10.1021/Cb400133J |
0.595 |
|
| 2013 |
Wang G, Coleman CG, Chan J, Faraco G, Marques-Lopes J, Milner TA, Guruju MR, Anrather J, Davisson RL, Iadecola C, Pickel VM. Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R1096-106. PMID 23576605 DOI: 10.1152/Ajpregu.00367.2012 |
0.491 |
|
| 2013 |
Cai L, Rothbart SB, Lu R, Xu B, Chen WY, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, Wang GG. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell. 49: 571-82. PMID 23273982 DOI: 10.1016/J.Molcel.2012.11.026 |
0.782 |
|
| 2012 |
Kumar GS, Chang W, Xie T, Patel A, Zhang Y, Wang GG, David G, Radhakrishnan I. Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. Journal of Molecular Biology. 422: 519-31. PMID 22728643 DOI: 10.1016/J.Jmb.2012.06.013 |
0.629 |
|
| 2012 |
Wang G, Coleman CG, Glass MJ, Zhou P, Yu Q, Park L, Anrather J, Pickel VM, Iadecola C. Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 302: R1076-83. PMID 22378773 DOI: 10.1152/Ajpregu.00571.2011 |
0.471 |
|
| 2010 |
Chi P, Allis CD, Wang GG. Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nature Reviews. Cancer. 10: 457-69. PMID 20574448 DOI: 10.1038/Nrc2876 |
0.705 |
|
| 2010 |
Milne TA, Kim J, Wang GG, Stadler SC, Basrur V, Whitcomb SJ, Wang Z, Ruthenburg AJ, Elenitoba-Johnson KS, Roeder RG, Allis CD. Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Molecular Cell. 38: 853-63. PMID 20541448 DOI: 10.1016/J.Molcel.2010.05.011 |
0.786 |
|
| 2010 |
Wang Z, Song J, Milne TA, Wang GG, Li H, Allis CD, Patel DJ. Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell. 141: 1183-94. PMID 20541251 DOI: 10.1016/J.Cell.2010.05.016 |
0.712 |
|
| 2010 |
Wang G, Badylak SF, Heber-Katz E, Braunhut SJ, Gudas LJ. The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. Regenerative Medicine. 5: 201-20. PMID 20210581 DOI: 10.2217/Rme.09.91 |
0.557 |
|
| 2010 |
Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH. Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proceedings of the National Academy of Sciences of the United States of America. 107: 3135-40. PMID 20133638 DOI: 10.1073/Pnas.0914142107 |
0.668 |
|
| 2009 |
Wang GG, Allis CD. "Misinterpretation" of a histone mark is linked to aberrant stem cells and cancer development. Cell Cycle (Georgetown, Tex.). 8: 1982-3. PMID 19550157 DOI: 10.4161/Cc.8.13.9106 |
0.667 |
|
| 2009 |
Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, Luo JL, Patel DJ, Allis CD. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature. 459: 847-51. PMID 19430464 DOI: 10.1038/Nature08036 |
0.733 |
|
| 2008 |
Wang G, Milner TA, Speth RC, Gore AC, Wu D, Iadecola C, Pierce JP. Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R1149-57. PMID 18685065 DOI: 10.1152/Ajpregu.90485.2008 |
0.462 |
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| 2008 |
Baker LA, Allis CD, Wang GG. PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutation Research. 647: 3-12. PMID 18682256 DOI: 10.1016/J.Mrfmmm.2008.07.004 |
0.714 |
|
| 2007 |
Wang GG, Allis CD, Chi P. Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. Trends in Molecular Medicine. 13: 373-80. PMID 17822959 DOI: 10.1016/J.Molmed.2007.07.004 |
0.698 |
|
| 2007 |
Wang GG, Allis CD, Chi P. Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends in Molecular Medicine. 13: 363-72. PMID 17822958 DOI: 10.1016/J.Molmed.2007.07.003 |
0.696 |
|
| 2007 |
Wang GG, Cai L, Pasillas MP, Kamps MP. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nature Cell Biology. 9: 804-12. PMID 17589499 DOI: 10.1038/ncb1608 |
0.771 |
|
| 2007 |
Wang G, Thai NM, Yau ST. Preserved enzymatic activity of glucose oxidase immobilized on unmodified electrodes for glucose detection. Biosensors & Bioelectronics. 22: 2158-64. PMID 17113278 DOI: 10.1016/J.Bios.2006.10.015 |
0.452 |
|
| 2007 |
Wang GG, Kamps MP. Survival signaling in HoxA9/Meis1 AML Blood. 109: 3619-3620. DOI: 10.1182/blood-2007-02-072785 |
0.635 |
|
| 2006 |
Wang GG, Pasillas MP, Kamps MP. Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes. Molecular and Cellular Biology. 26: 3902-16. PMID 16648484 DOI: 10.1128/MCB.26.10.3902-3916.2006 |
0.741 |
|
| 2006 |
Wang GG, Calvo KR, Pasillas MP, Sykes DB, Häcker H, Kamps MP. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nature Methods. 3: 287-93. PMID 16554834 DOI: 10.1038/Nmeth865 |
0.76 |
|
| 2006 |
Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 439: 204-7. PMID 16306937 DOI: 10.1038/Nature04369 |
0.664 |
|
| 2005 |
Wang GG, Pasillas MP, Kamps MP. Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus. Blood. 106: 254-64. PMID 15755900 DOI: 10.1182/blood-2004-12-4664 |
0.717 |
|
| 2005 |
Wang GG, Pasillas MP, Kamps MP. Fusion to Vp16 Converts MEIS1 into an Oncoprotein That Immortalizes Progenitors and Causes AML in the Absence of Coexpressed Hox Genes: Hoxa7 and Hoxa9 Induced Further Stem Cell Gene Transcription in Vp16MEIS1 Progenitors. Blood. 106: 662-662. DOI: 10.1182/blood.v106.11.662.662 |
0.744 |
|
| 2004 |
Wang G, Anrather J, Huang J, Speth RC, Pickel VM, Iadecola C. NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5516-24. PMID 15201324 DOI: 10.1523/Jneurosci.1176-04.2004 |
0.493 |
|
| 2004 |
Wang G, Lemos JR, Iadecola C. Herbal alkaloid tetrandrine: fron an ion channel blocker to inhibitor of tumor proliferation. Trends in Pharmacological Sciences. 25: 120-3. PMID 15058281 DOI: 10.1016/J.Tips.2004.01.009 |
0.482 |
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