129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Batebi H, Pérez-Hernández G, Rahman SN, Lan B, Kamprad A, Shi M, Speck D, Tiemann JKS, Guixà-González R, Reinhardt F, Stadler PF, Papasergi-Scott MM, Skiniotis G, Scheerer P, Kobilka BK, et al. Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor. Nature Structural & Molecular Biology. PMID 38867113 DOI: 10.1038/s41594-024-01334-2  0.818
2024 Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, ... ... Skiniotis G, et al. AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.). eadn6354. PMID 38753765 DOI: 10.1126/science.adn6354  0.781
2024 Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G-protein activation by a GPCR. Nature. PMID 38480881 DOI: 10.1038/s41586-024-07153-1  0.84
2024 He F, Wu CG, Gao Y, Rahman SN, Zaoralová M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G. Allosteric modulation and G-protein selectivity of the Ca-sensing receptor. Nature. PMID 38326620 DOI: 10.1038/s41586-024-07055-2  0.832
2023 Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G. Structure-based discovery of positive allosteric modulators for the calcium sensing receptor. Biorxiv : the Preprint Server For Biology. PMID 38234749 DOI: 10.1101/2023.12.27.573448  0.312
2023 Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, ... ... Skiniotis G, et al. AlphaFold2 structures template ligand discovery. Biorxiv : the Preprint Server For Biology. PMID 38187536 DOI: 10.1101/2023.12.20.572662  0.79
2023 Vizurraga AL, Robertson MJ, Yu M, Skiniotis G, Tall GG. Hexahydroquinoline Derivatives Are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56. Molecular Pharmacology. 104: 28-41. PMID 37290962 DOI: 10.1124/molpharm.123.000688  0.557
2023 Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B. Structural basis for activation of CB1 by an endocannabinoid analog. Nature Communications. 14: 2672. PMID 37160876 DOI: 10.1038/s41467-023-37864-4  0.65
2023 Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G protein activation by a GPCR. Biorxiv : the Preprint Server For Biology. PMID 36993214 DOI: 10.1101/2023.03.20.533387  0.84
2023 Papasergi-Scott MM, Kwarcinski FE, Yu M, Panova O, Ovrutsky AM, Skiniotis G, Tall GG. Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms. Structure (London, England : 1993). PMID 36931277 DOI: 10.1016/j.str.2023.02.011  0.806
2022 Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, ... ... Skiniotis G, et al. Structure-based design of bitopic ligands for the µ-opioid receptor. Nature. PMID 36450356 DOI: 10.1038/s41586-022-05588-y  0.783
2022 Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, ... ... Skiniotis G, et al. Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature Chemical Biology. PMID 36411392 DOI: 10.1038/s41589-022-01208-y  0.818
2022 Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G. Structure determination of inactive-state GPCRs with a universal nanobody. Nature Structural & Molecular Biology. PMID 36396979 DOI: 10.1038/s41594-022-00859-8  0.823
2022 Kaplan AL, Confair DN, Kim K, Barros-Álvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, ... ... Skiniotis G, et al. Bespoke library docking for 5-HT receptor agonists with antidepressant activity. Nature. PMID 36171289 DOI: 10.1038/s41586-022-05258-z  0.802
2022 Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, ... ... Skiniotis G, et al. Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. PMID 36087581 DOI: 10.1016/j.neuron.2022.08.006  0.796
2022 Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD. Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nature Communications. 13: 5232. PMID 36064945 DOI: 10.1038/s41467-022-32822-y  0.733
2022 Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G. Author Correction: Plasticity in ligand recognition at somatostatin receptors. Nature Structural & Molecular Biology. PMID 35804245 DOI: 10.1038/s41594-022-00813-8  0.539
2022 Robertson MJ, Skiniotis G. Development of OPLS-AA/M Parameters for Simulations of G Protein-Coupled Receptors and Other Membrane Proteins. Journal of Chemical Theory and Computation. PMID 35687850 DOI: 10.1021/acs.jctc.2c00015  0.531
2022 Barros-Álvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, ... ... Skiniotis G, et al. The tethered peptide activation mechanism of adhesion GPCRs. Nature. PMID 35418682 DOI: 10.1038/s41586-022-04575-7  0.809
2022 Gmeiner P, Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hübner H, Skiniotis G, Kobilka BK. Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists. Angewandte Chemie (International Ed. in English). PMID 35385593 DOI: 10.1002/anie.202200269  0.765
2022 Meyerowitz JG, Robertson MJ, Barros-Álvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G. The oxytocin signaling complex reveals a molecular switch for cation dependence. Nature Structural & Molecular Biology. PMID 35241813 DOI: 10.1038/s41594-022-00728-4  0.837
2022 Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G. Plasticity in ligand recognition at somatostatin receptors. Nature Structural & Molecular Biology. PMID 35210615 DOI: 10.1038/s41594-022-00727-5  0.616
2022 Tsutsumi N, Maeda S, Qu Q, Vögele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC. Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. Science Advances. 8: eabl5442. PMID 35061538 DOI: 10.1126/sciadv.abl5442  0.729
2021 Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L. Structure and mechanism of the SGLT family of glucose transporters. Nature. PMID 34880492 DOI: 10.1038/s41586-021-04211-w  0.739
2021 Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA. Structural insights into GIRK2 channel modulation by cholesterol and PIP. Cell Reports. 36: 109619. PMID 34433062 DOI: 10.1016/j.celrep.2021.109619  0.791
2021 Robertson MJ, Meyerowitz JG, Skiniotis G. Drug discovery in the era of cryo-electron microscopy. Trends in Biochemical Sciences. PMID 34281791 DOI: 10.1016/j.tibs.2021.06.008  0.506
2021 Robertson MJ, Meyerowitz JG, Skiniotis G. Drug discovery in the era of cryo-electron microscopy. Trends in Biochemical Sciences. PMID 34281791 DOI: 10.1016/j.tibs.2021.06.008  0.506
2021 Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC. Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. Immunity. PMID 34216564 DOI: 10.1016/j.immuni.2021.06.001  0.775
2021 Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Bräuner-Osborne H, Mathiesen JM, Skiniotis G. Asymmetric activation of the calcium-sensing receptor homodimer. Nature. PMID 34194040 DOI: 10.1038/s41586-021-03691-0  0.817
2021 Seven AB, Barros-Álvarez X, de Lapeyrière M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G. G-protein activation by a metabotropic glutamate receptor. Nature. PMID 34194039 DOI: 10.1038/s41586-021-03680-3  0.827
2021 Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA. Structure of the visual signaling complex between transducin and phosphodiesterase 6. Molecular Cell. 81: 2496. PMID 34087182 DOI: 10.1016/j.molcel.2021.05.006  0.767
2021 Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC. Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell. 184: 983-999.e24. PMID 33606986 DOI: 10.1016/j.cell.2021.01.018  0.765
2020 Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA. Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6. Molecular Cell. PMID 33007200 DOI: 10.1016/j.molcel.2020.09.013  0.822
2020 Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL. Structure of a Hallucinogen-Activated Gq-Coupled 5-HT Serotonin Receptor. Cell. 182: 1574-1588.e19. PMID 32946782 DOI: 10.1016/J.Cell.2020.08.024  0.806
2020 Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK. Structural insights into differences in G protein activation by family A and family B GPCRs. Science (New York, N.Y.). 369. PMID 32732395 DOI: 10.1126/Science.Aba3373  0.74
2020 Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G. Structures of metabotropic GABA receptor. Nature. PMID 32580208 DOI: 10.1038/S41586-020-2469-4  0.813
2020 Robertson MJ, van Zundert GCP, Borrelli K, Skiniotis G. GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps. Structure (London, England : 1993). PMID 32413291 DOI: 10.1016/J.Str.2020.04.018  0.574
2020 Kan W, Enos MD, Korkmazhan E, Muennich S, Chen DH, Gammons MV, Vasishtha M, Bienz M, Dunn AR, Skiniotis G, Weis WI. Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction. Elife. 9. PMID 32297861 DOI: 10.7554/Elife.55015  0.338
2020 Wouters E, Walraed J, Robertson MJ, Meyrath M, Szpakowska M, Chevigné A, Skiniotis G, Stove C. Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds. Acs Pharmacology & Translational Science. 3: 285-295. PMID 32296768 DOI: 10.1021/acsptsci.9b00069  0.597
2020 Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G. Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Reports. PMID 32126208 DOI: 10.1016/J.Celrep.2020.02.086  0.792
2020 Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G. Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc. Nature. PMID 31945772 DOI: 10.1038/S41586-020-1954-0  0.812
2020 Huang W, Masureel M, Qianhui Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK. Structure of the neurotensin receptor 1 in complex with β-arrestin 1. Nature. PMID 31945771 DOI: 10.1038/S41586-020-1953-1  0.696
2020 Glaaser IW, Mathiharan YK, Zhao Y, Skiniotis G, Slesinger PA. CRYO-EM Structures of the GIRK2 Channel Reveal Mechanisms for Lipid Modulation Biophysical Journal. 118: 497a-498a. DOI: 10.1016/J.Bpj.2019.11.2749  0.774
2019 Yang Y, Joshi M, Takahashi YH, Ning Z, Qu Q, Brunzelle JS, Skiniotis G, Figeys D, Shilatifard A, Couture JF. A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS. Nucleic Acids Research. PMID 31724694 DOI: 10.1093/Nar/Gkz1037  0.747
2019 Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G. Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation. Molecular Cell. PMID 31300275 DOI: 10.2210/Pdb6Oy9/Pdb  0.797
2019 Chae PS, Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK. Self-assembly behaviors and application of terphenyl-cored trimaltosides for membrane protein study: Impact of detergent hydrophobic group geometry on protein stability. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31243822 DOI: 10.1002/Chem.201902468  0.738
2019 Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G. Conformational transitions of a neurotensin receptor 1-G complex. Nature. PMID 31243364 DOI: 10.1038/s41586-019-1337-6  0.745
2019 Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK. Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science (New York, N.Y.). 364: 552-557. PMID 31073061 DOI: 10.1126/Science.Aaw5188  0.819
2019 Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, ... Skiniotis G, et al. Author Correction: Structural insights into the activation of metabotropic glutamate receptors. Nature. PMID 30814739 DOI: 10.1038/S41586-019-0983-Z  0.785
2019 Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, ... Skiniotis G, et al. Structural insights into the activation of metabotropic glutamate receptors. Nature. PMID 30675062 DOI: 10.1038/s41586-019-0881-4  0.837
2019 Kato HE, Zhang Y, Hu H, Suomivuori C, Kadji FMN, Aoki J, Kumar KK, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G. Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature. 572: 80-85. DOI: 10.2210/Pdb6Os9/Pdb  0.77
2018 Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, ... Skiniotis G, et al. Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell. PMID 30639101 DOI: 10.1016/J.Cell.2018.11.040  0.833
2018 Kappel K, Liu S, Larsen KP, Skiniotis G, Puglisi EV, Puglisi JD, Zhou ZH, Zhao R, Das R. De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes. Nature Methods. 15: 947-954. PMID 30377372 DOI: 10.1038/S41592-018-0172-2  0.31
2018 Haddad JF, Yang Y, Takahashi YH, Joshi M, Chaudhary N, Woodfin A, Benyoucef A, Yeung S, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF. Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation. Structure (London, England : 1993). PMID 30270175 DOI: 10.1016/J.Str.2018.08.004  0.345
2018 Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK. Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nature Communications. 9: 3712. PMID 30213947 DOI: 10.1038/S41467-018-06002-W  0.728
2018 Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G. Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex. Cell. 174: 1117-1126.e12. PMID 30100186 DOI: 10.1016/J.Cell.2018.07.020  0.813
2018 Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, ... Skiniotis G, et al. Structure of the µ-opioid receptor-G protein complex. Nature. PMID 29899455 DOI: 10.1038/S41586-018-0219-7  0.837
2018 Larsen KP, Mathiharan YK, Kappel K, Coey AT, Chen DH, Barrero D, Madigan L, Puglisi JD, Skiniotis G, Puglisi EV. Architecture of an HIV-1 reverse transcriptase initiation complex. Nature. PMID 29695867 DOI: 10.1038/S41586-018-0055-9  0.784
2018 Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, Skiniotis G, Araç D. Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse. Cell. 173: 735-748.e15. PMID 29677516 DOI: 10.1016/J.Cell.2018.03.036  0.799
2018 Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Vitamin E-based glycoside amphiphiles for membrane protein structural studies. Organic & Biomolecular Chemistry. PMID 29564464 DOI: 10.1039/C8Ob00270C  0.74
2018 Zhang Y, Hong S, Ruangprasert A, Skiniotis G, Dunham CM. Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel. Structure (London, England : 1993). PMID 29456023 DOI: 10.1016/J.Str.2018.01.013  0.346
2018 Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, ... Skiniotis G, et al. Structure of the mu-opioid receptor-Giprotein complex. Nature. 558: 547-552. DOI: 10.2210/Pdb6Dde/Pdb  0.801
2018 Larsen K, Mathiharan Y, Kappel K, Coey A, Chen D, Madigan L, Skiniotis G, Puglisi J, Viani Puglisi E. Structural Characterization of the HIV-1 Reverse Transcriptase Initiation Complex Biophysical Journal. 114: 193a. DOI: 10.1016/J.Bpj.2017.11.1080  0.776
2017 Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS. Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study. Chemical Science. 8: 8315-8324. PMID 29619178 DOI: 10.1039/C7Sc03700G  0.741
2017 Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. Cell. 171: 1638-1648.e7. PMID 29224781 DOI: 10.1016/J.Cell.2017.11.014  0.425
2017 Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. Cell. 171: 1638-1648.e7. PMID 29224781 DOI: 10.1016/j.cell.2017.11.014  0.311
2017 Shalev-Benami M, Zhang Y, Rozenberg H, Nobe Y, Taoka M, Matzov D, Zimmerman E, Bashan A, Isobe T, Jaffe CL, Yonath A, Skiniotis G. Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nature Communications. 8: 1589. PMID 29150609 DOI: 10.2210/Pdb6Az1/Pdb  0.787
2017 Ehsan M, Ghani L, Du Y, Hariharan P, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. The Analyst. PMID 28913526 DOI: 10.1039/C7An01168G  0.693
2017 Gu S, Sachleben JR, Boughter CT, Nawrocka WI, Borowska MT, Tarrasch JT, Skiniotis G, Roux B, Adams EJ. Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28807997 DOI: 10.1073/Pnas.1707547114  0.36
2017 Gao Y, Westfield G, Erickson JW, Cerione RA, Skiniotis G, Ramachandran S. Isolation and Structure-function Characterization of a Signaling-active Rhodopsin-G protein Complex. The Journal of Biological Chemistry. PMID 28655769 DOI: 10.1074/Jbc.M117.797100  0.835
2017 Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G. Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature. PMID 28538729 DOI: 10.1038/Nature22394  0.845
2017 Su M, Guo EZ, Ding X, Li Y, Tarrasch JT, Brooks CL, Xu Z, Skiniotis G. Mechanism of Vps4 hexamer function revealed by cryo-EM. Science Advances. 3: e1700325. PMID 28439563 DOI: 10.1126/Sciadv.1700325  0.411
2017 Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, ... ... Skiniotis G, et al. Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature. PMID 28437792 DOI: 10.1038/Nature22327  0.531
2017 Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL. Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. Cell. 169: 407-421.e16. PMID 28431242 DOI: 10.1016/J.Cell.2017.03.047  0.519
2017 Cahill TJ, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J, ... ... Skiniotis G, et al. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223524 DOI: 10.1073/Pnas.1701529114  0.482
2017 Das M, Du Y, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties. Journal of the American Chemical Society. PMID 28218862 DOI: 10.1021/Jacs.6B11997  0.346
2017 De M, Oleskie AN, Ayyash M, Dutta S, Mancour L, Abazeed ME, Brace EJ, Skiniotis G, Fuller RS. The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion. The Journal of Cell Biology. PMID 28122955 DOI: 10.1083/Jcb.201606078  0.794
2016 Cheng S, Seven AB, Wang J, Skiniotis G, Özkan E. Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex. Structure (London, England : 1993). 24: 2163-2173. PMID 27926833 DOI: 10.1016/J.Str.2016.11.004  0.764
2016 Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, et al. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. PMID 27499021 DOI: 10.1016/J.Cell.2016.07.004  0.483
2016 Sciore A, Su M, Koldewey P, Eschweiler JD, Diffley KA, Linhares BM, Ruotolo BT, Bardwell JC, Skiniotis G, Marsh EN. Flexible, symmetry-directed approach to assembling protein cages. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432965 DOI: 10.1073/Pnas.1606013113  0.399
2016 Shalev-Benami M, Zhang Y, Matzov D, Halfon Y, Zackay A, Rozenberg H, Zimmerman E, Bashan A, Jaffe CL, Yonath A, Skiniotis G. 2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania. Cell Reports. PMID 27373148 DOI: 10.1016/J.Celrep.2016.06.014  0.793
2016 Ehsan M, Du Y, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies. Journal of the American Chemical Society. PMID 26966956 DOI: 10.1021/Jacs.5B13233  0.374
2016 Drake EJ, Miller BR, Shi C, Tarrasch JT, Sundlov JA, Allen CL, Skiniotis G, Aldrich CC, Gulick AM. Structures of two distinct conformations of holo-non-ribosomal peptide synthetases. Nature. 529: 235-8. PMID 26762461 DOI: 10.1038/Nature16163  0.389
2015 Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. Plos Pathogens. 11: e1005322. PMID 26646856 DOI: 10.1371/Journal.Ppat.1005322  0.641
2015 Skiniotis G, Southworth DR. Single-particle cryo-electron microscopy of macromolecular complexes. Microscopy (Oxford, England). PMID 26611544 DOI: 10.1093/Jmicro/Dfv366  0.315
2015 Verma V, Mallik L, Hariadi RF, Sivaramakrishnan S, Skiniotis G, Joglekar AP. Using Protein Dimers to Maximize the Protein Hybridization Efficiency with Multisite DNA Origami Scaffolds. Plos One. 10: e0137125. PMID 26348722 DOI: 10.1371/Journal.Pone.0137125  0.318
2015 Peisley A, Skiniotis G. 2D Projection Analysis of GPCR Complexes by Negative Stain Electron Microscopy. Methods in Molecular Biology (Clifton, N.J.). 1335: 29-38. PMID 26260592 DOI: 10.1007/978-1-4939-2914-6_3  0.362
2015 Inoue T, Dosey A, Herbstman JF, Ravindran MS, Skiniotis G, Tsai B. The ERdj5 reductase cooperates with PDI to promote SV40 ER membrane translocation. Journal of Virology. PMID 26085143 DOI: 10.1128/Jvi.00941-15  0.775
2015 Yee A, Oleskie AN, Dosey AM, Kretz CA, Gildersleeve RD, Dutta S, Su M, Ginsburg D, Skiniotis G. Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII. Blood. PMID 26065653 DOI: 10.1182/Blood-2015-04-641696  0.778
2015 Smith JL, Skiniotis G, Sherman DH. Architecture of the polyketide synthase module: surprises from electron cryo-microscopy. Current Opinion in Structural Biology. 31: 9-19. PMID 25791608 DOI: 10.1016/J.Sbi.2015.02.014  0.349
2015 Zhang P, Chaturvedi CP, Tremblay V, Cramet M, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF. A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Genes & Development. 29: 123-8. PMID 25593305 DOI: 10.1101/Gad.254870.114  0.431
2014 Tremblay V, Zhang P, Chaturvedi CP, Thornton J, Brunzelle JS, Skiniotis G, Shilatifard A, Brand M, Couture JF. Molecular basis for DPY-30 association to COMPASS-like and NURF complexes. Structure (London, England : 1993). 22: 1821-30. PMID 25456412 DOI: 10.1016/J.Str.2014.10.002  0.406
2014 Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, ... ... Skiniotis G, et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 512: 218-22. PMID 25043026 DOI: 10.1038/Nature13430  0.84
2014 Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature. 510: 560-4. PMID 24965656 DOI: 10.1038/Nature13409  0.676
2014 Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structure of a modular polyketide synthase. Nature. 510: 512-7. PMID 24965652 DOI: 10.1038/Nature13423  0.658
2014 Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL. Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system. Science (New York, N.Y.). 343: 881-5. PMID 24505133 DOI: 10.1126/Science.1247749  0.664
2014 Vashisth H, Skiniotis G, Brooks CL. Collective variable approaches for single molecule flexible fitting and enhanced sampling. Chemical Reviews. 114: 3353-65. PMID 24446720 DOI: 10.1021/Cr4005988  0.344
2014 Thornton JL, Westfield GH, Takahashi YH, Cook M, Gao X, Woodfin AR, Lee JS, Morgan MA, Jackson J, Smith ER, Couture JF, Skiniotis G, Shilatifard A. Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation. Genes & Development. 28: 115-20. PMID 24402317 DOI: 10.1101/Gad.232215.113  0.766
2014 Patterson DP, Su M, Franzmann TM, Sciore A, Skiniotis G, Marsh EN. Characterization of a highly flexible self-assembling protein system designed to form nanocages. Protein Science : a Publication of the Protein Society. 23: 190-9. PMID 24318954 DOI: 10.1002/Pro.2405  0.352
2013 Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K. Inhibition of AMPK catabolic action by GSK3. Molecular Cell. 50: 407-19. PMID 23623684 DOI: 10.1016/J.Molcel.2013.03.022  0.302
2013 Vashisth H, Skiniotis G, Brooks CL. Enhanced sampling and overfitting analyses in structural refinement of nucleic acids into electron microscopy maps. The Journal of Physical Chemistry. B. 117: 3738-46. PMID 23506287 DOI: 10.1021/Jp3126297  0.351
2013 Couture JF, Skiniotis G. Assembling a COMPASS. Epigenetics : Official Journal of the Dna Methylation Society. 8: 349-54. PMID 23470558 DOI: 10.4161/Epi.24177  0.331
2013 Cline EN, Li MH, Choi SK, Herbstman JF, Kaul N, Meyhöfer E, Skiniotis G, Baker JR, Larson RG, Walter NG. Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action. Biomacromolecules. 14: 654-64. PMID 23391096 DOI: 10.1021/Bm301719B  0.783
2013 Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ. Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain. Nature Structural & Molecular Biology. 20: 355-62. PMID 23377541 DOI: 10.1038/Nsmb.2497  0.699
2013 Sherman D, Skiniotis G, Smith J, Håkansson K, Dutta S, Whicher J, Hansen D, Hale W, Chemler J, Congdon G, Narayan A. The Structure and Rearrangements of a Complete Polyketide Synthase Module During its Catalytic Cycle Planta Medica. 79. DOI: 10.1055/S-0033-1348499  0.638
2012 Soppina V, Herbstman JF, Skiniotis G, Verhey KJ. Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules. Plos One. 7: e48204. PMID 23110214 DOI: 10.1371/Journal.Pone.0048204  0.785
2012 Mancour LV, Daghestani HN, Dutta S, Westfield GH, Schilling J, Oleskie AN, Herbstman JF, Chou SZ, Skiniotis G. Ligand-induced architecture of the leptin receptor signaling complex. Molecular Cell. 48: 655-61. PMID 23063524 DOI: 10.1016/J.Molcel.2012.09.003  0.771
2012 Vashisth H, Skiniotis G, Brooks CL. Using enhanced sampling and structural restraints to refine atomic structures into low-resolution electron microscopy maps. Structure (London, England : 1993). 20: 1453-62. PMID 22958641 DOI: 10.1016/J.Str.2012.08.007  0.323
2012 Chan YP, Lu M, Dutta S, Yan L, Barr J, Flora M, Feng YR, Xu K, Nikolov DB, Wang LF, Skiniotis G, Broder CC. Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins. Journal of Virology. 86: 11457-71. PMID 22915804 DOI: 10.1128/Jvi.01318-12  0.659
2012 Thompson AD, Bernard SM, Skiniotis G, Gestwicki JE. Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK). Cell Stress & Chaperones. 17: 313-27. PMID 22076723 DOI: 10.1007/S12192-011-0307-1  0.398
2012 Yee A, Oleskie AN, Gildersleeve RD, Kretz CA, Su M, McGee BM, Carr KM, Skiniotis G, Ginsburg D. Partial in Vivo FVIII Stabilization by VWF Fragments Blood. 120: 15-15. DOI: 10.1182/Blood.V120.21.15.15  0.775
2012 Cline E, Li M, Ki Choi S, Herbstman J, Kaul N, Meyhofer E, Skiniotis G, Baker JR, Larson RG, Walter NG. Taxol-Conjugated Pamam Dendrimers Utilize Three Modes of Action on Microtubule Structure Biophysical Journal. 102: 187a. DOI: 10.1016/J.Bpj.2011.11.1022  0.788
2011 Takahashi YH, Westfield GH, Oleskie AN, Trievel RC, Shilatifard A, Skiniotis G. Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human. Proceedings of the National Academy of Sciences of the United States of America. 108: 20526-31. PMID 22158900 DOI: 10.1073/Pnas.1109360108  0.792
2011 Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL, Steyaert J, ... ... Skiniotis G, et al. Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 16086-91. PMID 21914848 DOI: 10.1073/Pnas.1113645108  0.823
2011 Strunk BS, Loucks CR, Su M, Vashisth H, Cheng S, Schilling J, Brooks CL, Karbstein K, Skiniotis G. Ribosome assembly factors prevent premature translation initiation by 40S assembly intermediates. Science (New York, N.Y.). 333: 1449-53. PMID 21835981 DOI: 10.1126/Science.1208245  0.783
2011 Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, ... ... Skiniotis G, et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature. 477: 549-55. PMID 21772288 DOI: 10.1038/Nature10361  0.532
2011 Gu L, Eisman EB, Dutta S, Franzmann TM, Walter S, Gerwick WH, Skiniotis G, Sherman DH. Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angewandte Chemie (International Ed. in English). 50: 2795-8. PMID 21387490 DOI: 10.1002/Anie.201005280  0.611
2011 Lupardus PJ, Skiniotis G, Rice AJ, Thomas C, Fischer S, Walz T, Garcia KC. Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (London, England : 1993). 19: 45-55. PMID 21220115 DOI: 10.1016/J.Str.2010.10.010  0.578
2010 Mancour L, Schilling J, Skiniotis G. Structural Characterization of the Activated Leptin Receptor Complex Microscopy and Microanalysis. 16: 1064-1065. DOI: 10.1017/S1431927610061404  0.81
2008 Skiniotis G, Lupardus PJ, Martick M, Walz T, Garcia KC. Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Molecular Cell. 31: 737-48. PMID 18775332 DOI: 10.1016/J.Molcel.2008.08.011  0.598
2007 Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D. Structural basis of Dscam isoform specificity. Nature. 449: 487-91. PMID 17721508 DOI: 10.1038/Nature06147  0.563
2007 Skiniotis G, Moazed D, Walz T. Acetylated histone tail peptides induce structural rearrangements in the RSC chromatin remodeling complex. The Journal of Biological Chemistry. 282: 20804-8. PMID 17535815 DOI: 10.1074/Jbc.C700081200  0.536
2007 Ruch C, Skiniotis G, Steinmetz MO, Walz T, Ballmer-Hofer K. Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nature Structural & Molecular Biology. 14: 249-50. PMID 17293873 DOI: 10.1038/Nsmb1202  0.62
2005 Skiniotis G, Boulanger MJ, Garcia KC, Walz T. Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nature Structural & Molecular Biology. 12: 545-51. PMID 15895091 DOI: 10.1038/Nsmb941  0.598
2004 Santarella RA, Skiniotis G, Goldie KN, Tittmann P, Gross H, Mandelkow EM, Mandelkow E, Hoenger A. Surface-decoration of microtubules by human tau. Journal of Molecular Biology. 339: 539-53. PMID 15147841 DOI: 10.1016/J.Jmb.2004.04.008  0.615
2004 Skiniotis G, Cochran JC, Müller J, Mandelkow E, Gilbert SP, Hoenger A. Modulation of kinesin binding by the C-termini of tubulin. The Embo Journal. 23: 989-99. PMID 14976555 DOI: 10.1038/Sj.Emboj.7600118  0.624
2003 Skiniotis G, Surrey T, Altmann S, Gross H, Song YH, Mandelkow E, Hoenger A. Nucleotide-induced conformations in the neck region of dimeric kinesin. The Embo Journal. 22: 1518-28. PMID 12660159 DOI: 10.1093/Emboj/Cdg164  0.629
2003 Wendt T, Skiniotis G, Hoenger A. Cryo-electron microscopy and 3-D image analysis of microtubules complexed with molecular motors Microscopy and Microanalysis. 9: 398-399. DOI: 10.1017/S1431927603033063  0.588
2002 Wendt TG, Volkmann N, Skiniotis G, Goldie KN, Müller J, Mandelkow E, Hoenger A. Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. The Embo Journal. 21: 5969-78. PMID 12426369 DOI: 10.1093/Emboj/Cdf622  0.626
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