| Year |
Citation |
Score |
| 2023 |
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. PMID 37100955 DOI: 10.1038/s41418-023-01153-w |
0.447 |
|
| 2022 |
Xu J, Núñez G. The NLRP3 inflammasome: activation and regulation. Trends in Biochemical Sciences. PMID 36336552 DOI: 10.1016/j.tibs.2022.10.002 |
0.3 |
|
| 2020 |
Duan Y, Zhang L, Angosto-Bazarra D, Pelegrín P, Núñez G, He Y. RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly. Cell Reports. 33: 108405. PMID 33207200 DOI: 10.1016/j.celrep.2020.108405 |
0.343 |
|
| 2020 |
Caballero-Flores G, Pickard JM, Fukuda S, Inohara N, Núñez G. An Enteric Pathogen Subverts Colonization Resistance by Evading Competition for Amino Acids in the Gut. Cell Host & Microbe. PMID 32726577 DOI: 10.1016/J.Chom.2020.06.018 |
0.319 |
|
| 2020 |
Caruso R, Lo BC, Núñez G. Host-microbiota interactions in inflammatory bowel disease. Nature Reviews. Immunology. PMID 32005980 DOI: 10.1038/S41577-019-0268-7 |
0.372 |
|
| 2019 |
Lipinski S, Pfeuffer S, Arnold P, Treitz C, Aden K, Ebsen H, Falk-Paulsen M, Gisch N, Fazio A, Kuiper J, Luzius A, Billmann-Born S, Schreiber S, Nuñez G, Beer HD, et al. Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles. The Embo Journal. e101266. PMID 31544965 DOI: 10.15252/Embj.2018101266 |
0.475 |
|
| 2019 |
Kim D, Kim YM, Kim WU, Park JH, Núñez G, Seo SU. Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of interleukin-1β. Immunology. PMID 31478196 DOI: 10.1111/Imm.13105 |
0.385 |
|
| 2019 |
Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature. PMID 31189953 DOI: 10.1038/S41586-019-1295-Z |
0.351 |
|
| 2019 |
Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O'Neill L, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG. Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. Allergy. PMID 30937919 DOI: 10.1111/All.13801 |
0.323 |
|
| 2019 |
Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, ... ... Nunez G, et al. Intestinal non-canonical NFκB signaling shapes the local and systemic immune response. Nature Communications. 10: 660. PMID 30737385 DOI: 10.1038/S41467-019-08581-8 |
0.375 |
|
| 2019 |
Caballero-Flores G, Sakamoto K, Zeng MY, Wang Y, Hakim J, Matus-Acuña V, Inohara N, Núñez G. Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk. Cell Host & Microbe. PMID 30686564 DOI: 10.1016/J.Chom.2018.12.015 |
0.322 |
|
| 2018 |
Hara H, Seregin SS, Yang D, Fukase K, Chamaillard M, Alnemri ES, Inohara N, Chen GY, Núñez G. The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. PMID 30392956 DOI: 10.1016/J.Cell.2018.09.047 |
0.433 |
|
| 2018 |
Fujiwara H, Docampo MD, Riwes M, Peltier D, Toubai T, Henig I, Wu SJ, Kim S, Taylor A, Brabbs S, Liu C, Zajac C, Oravecz-Wilson K, Sun Y, Núñez G, et al. Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nature Communications. 9: 3674. PMID 30201970 DOI: 10.1038/S41467-018-06048-W |
0.344 |
|
| 2018 |
Triner D, Castillo C, Hakim JB, Xue X, Greenson JK, Nuñez G, Chen GY, Colacino JA, Shah YM. Myc-Associated Zinc Finger Protein Regulates the Pro-Inflammatory Response in Colitis and Colon Cancer via STAT3 Signaling. Molecular and Cellular Biology. PMID 30181395 DOI: 10.1128/Mcb.00386-18 |
0.34 |
|
| 2018 |
Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS. Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease. The Journal of Clinical Investigation. PMID 30137026 DOI: 10.1172/Jci120453 |
0.308 |
|
| 2018 |
Hu Y, Song F, Jiang H, Nuñez G, Smith DE. SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages. Journal of Immunology (Baltimore, Md. : 1950). PMID 29784761 DOI: 10.4049/Jimmunol.1800210 |
0.349 |
|
| 2018 |
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4 |
0.473 |
|
| 2017 |
Nakagawa S, Matsumoto M, Katayama Y, Oguma R, Wakabayashi S, Nygaard T, Saijo S, Inohara N, Otto M, Matsue H, Núñez G, Nakamura Y. Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation. Cell Host & Microbe. 22: 667-677.e5. PMID 29120744 DOI: 10.1016/J.Chom.2017.10.008 |
0.369 |
|
| 2017 |
Hayakawa K, Formica AM, Zhou Y, Ichikawa D, Asano M, Li YS, Shinton SA, Brill-Dashoff J, Núñez G, Hardy RR. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. The Journal of Experimental Medicine. PMID 28878001 DOI: 10.1084/Jem.20170497 |
0.303 |
|
| 2017 |
Pickard JM, Zeng MY, Caruso R, Núñez G. Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunological Reviews. 279: 70-89. PMID 28856738 DOI: 10.1111/Imr.12567 |
0.377 |
|
| 2017 |
Kim D, Seo SU, Zeng MY, Kim WU, Kamada N, Inohara N, Núñez G. Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of SalmonellaTyphimurium via Inflammatory Monocytes. Journal of Immunology (Baltimore, Md. : 1950). PMID 28674182 DOI: 10.4049/Jimmunol.1601527 |
0.405 |
|
| 2017 |
Kim D, Zeng MY, Núñez G. The interplay between host immune cells and gut microbiota in chronic inflammatory diseases. Experimental & Molecular Medicine. 49: e339. PMID 28546562 DOI: 10.1038/Emm.2017.24 |
0.338 |
|
| 2017 |
Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, et al. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science (New York, N.Y.). 356: 315-319. PMID 28428425 DOI: 10.1126/Science.Aag2029 |
0.312 |
|
| 2017 |
Nunez G. Linking Pathogen Virulence, Host Immunity and The Microbiota at the Intestinal Barrier. The Keio Journal of Medicine. 66: 14. PMID 28356548 DOI: 10.2302/Kjm.66-001-Abst |
0.35 |
|
| 2017 |
Sakamoto K, Kim YG, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, Núñez G. IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections. Science Immunology. 2. PMID 28286877 DOI: 10.1126/Sciimmunol.Aai8371 |
0.391 |
|
| 2017 |
O'Brien M, Moehring D, Muñoz-Planillo R, Núñez G, Callaway J, Ting J, Scurria M, Ugo T, Bernad L, Cali J, Lazar D. A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells. Journal of Immunological Methods. PMID 28268194 DOI: 10.1016/J.Jim.2017.03.004 |
0.417 |
|
| 2017 |
Fattahi F, Grailer JJ, Lu H, Dick RS, Parlett M, Zetoune FS, Nuñez G, Ward PA. Selective Biological Responses of Phagocytes and Lungs to Purified Histones. Journal of Innate Immunity. PMID 28171866 DOI: 10.1159/000452951 |
0.355 |
|
| 2017 |
Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096356 DOI: 10.1073/Pnas.1613305114 |
0.463 |
|
| 2017 |
Shah D, Kadiyala P, Kamran N, Baker GJ, Doherty R, Zamler D, Nuñez G, Castro MG, Lowenstein PR. IMMU-26. TLR7 ACTIVATION IS ESSENTIAL FOR NK CELLS TO ELIMINATE GLIOMA TUMORS Neuro-Oncology. 19: vi118-vi118. DOI: 10.1093/Neuonc/Nox168.484 |
0.301 |
|
| 2017 |
Sakamoto K, Inohara N, Nunez G. IL-22 Controls Heme-Dependent Nutritional Immunity Against Systemic Bacterial Infection Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)30924-1 |
0.353 |
|
| 2017 |
Liu H, Archer N, Dillen C, Wang Y, Ashbaugh A, Ortines R, Lee S, Miller R, Marchitto M, Nunez G, Miller L. 629 Staphylococcus aureus drives atopic dermatitis-like skin inflammation via IL-36-induced IL-17 responses Journal of Investigative Dermatology. 137: S108. DOI: 10.1016/J.Jid.2017.02.651 |
0.334 |
|
| 2017 |
Nakagawa S, Nakamura Y, Nunez G, Matsue H. 624 PSMα as a key virulence in Staphylococcus aureus-induced skin inflammation through IL-36 and IL-1 release from keratinocytes Journal of Investigative Dermatology. 137. DOI: 10.1016/J.Jid.2017.02.646 |
0.333 |
|
| 2017 |
Nakagawa S, Nakamura Y, Ovum R, Katayama Y, Matsumoto M, Nunez G, Matsue H. Staphylococcus PSMα induces IL-17-dependent skin inflammation through IL-36 and IL-1 secretion from keratinocytes Journal of Dermatological Science. 86: 206. DOI: 10.1016/J.Jdermsci.2017.02.200 |
0.321 |
|
| 2016 |
He Y, Hara H, Núñez G. Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends in Biochemical Sciences. PMID 27669650 DOI: 10.1016/J.Tibs.2016.09.002 |
0.437 |
|
| 2016 |
Zeng MY, Inohara N, Nuñez G. Mechanisms of inflammation-driven bacterial dysbiosis in the gut. Mucosal Immunology. PMID 27554295 DOI: 10.1038/Mi.2016.75 |
0.348 |
|
| 2016 |
Kim D, Kim YG, Seo SU, Kim DJ, Kamada N, Prescott D, Philpott DJ, Rosenstiel P, Inohara N, Núñez G. Corrigendum: Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin. Nature Medicine. 22: 961. PMID 27490437 DOI: 10.1038/Nm0816-961 |
0.366 |
|
| 2016 |
Hou M, Chen R, Yang D, Núñez G, Wang Z, Wang Q, Zhang Y, Liu Q. Identification and functional characterization of EseH, a new effector of the type III secretion system of Edwardsiella piscicida. Cellular Microbiology. PMID 27367317 DOI: 10.1111/Cmi.12638 |
0.412 |
|
| 2016 |
Caruso R, Núñez G. Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation. Current Biology : Cb. 26: R508-11. PMID 27326714 DOI: 10.1016/J.Cub.2016.05.021 |
0.375 |
|
| 2016 |
Kim D, Kim YG, Seo SU, Kim DJ, Kamada N, Prescott D, Philpott DJ, Rosenstiel P, Inohara N, Núñez G. Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin. Nature Medicine. PMID 27064448 DOI: 10.1038/Nm.4075 |
0.366 |
|
| 2016 |
Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G. Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Immunity. PMID 26944199 DOI: 10.1016/J.Immuni.2016.02.006 |
0.36 |
|
| 2016 |
Navarro R, Delgado-Wicke P, Nuñez-Prado N, Compte M, Blanco-Toribio A, Nuñez G, Álvarez-Vallina L, Sanz L. Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation. Journal of Cellular and Molecular Medicine. 20: 980-6. PMID 26915562 DOI: 10.1111/Jcmm.12804 |
0.408 |
|
| 2016 |
He Y, Zeng MY, Yang D, Motro B, Núñez G. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. PMID 26814970 DOI: 10.1038/Nature16959 |
0.345 |
|
| 2016 |
Liu H, Archer N, Page C, Wang Y, Kao T, Lee S, Ortines R, Ashbaugh A, Nunez G, Miller L. 487 IL-36R-signaling promotes Staphylococcus aureus -induced atopic dermatitis-like skin inflammation Journal of Investigative Dermatology. 136: S86. DOI: 10.1016/J.Jid.2016.02.524 |
0.331 |
|
| 2016 |
Nakagawa S, Nakamura-Matsuoka Y, Katayama Y, Nunez G, Matsue H. Cooperation of IL-1 and IL-36 plays a pivotal role in epicutaneous S. aureus-induced skin inflammation via IL-17 production Journal of Dermatological Science. 84. DOI: 10.1016/J.Jdermsci.2016.08.476 |
0.322 |
|
| 2015 |
Yang D, He Y, Muñoz-Planillo R, Liu Q, Núñez G. Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock. Immunity. PMID 26572062 DOI: 10.1016/J.Immuni.2015.10.009 |
0.391 |
|
| 2015 |
Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, Ishikawa E, Shima T, Hara T, Kado S, Jinnohara T, et al. Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells. Cell. 163: 367-80. PMID 26411289 DOI: 10.1016/J.Cell.2015.08.058 |
0.34 |
|
| 2015 |
Bronner DN, Abuaita BH, Chen X, Fitzgerald KA, Nuñez G, He Y, Yin XM, O'Riordan MX. Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity. PMID 26341399 DOI: 10.1016/J.Immuni.2015.08.008 |
0.317 |
|
| 2015 |
Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG. Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. The Journal of Allergy and Clinical Immunology. PMID 26299987 DOI: 10.1016/J.Jaci.2015.06.045 |
0.322 |
|
| 2015 |
Seo SU, Kuffa P, Kitamoto S, Nagao-Kitamoto H, Rousseau J, Kim YG, Núñez G, Kamada N. Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells. Nature Communications. 6: 8010. PMID 26269452 DOI: 10.1038/Ncomms9010 |
0.414 |
|
| 2015 |
Kamada N, Sakamoto K, Seo SU, Zeng MY, Kim YG, Cascalho M, Vallance BA, Puente JL, Núñez G. Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination. Cell Host & Microbe. 17: 617-27. PMID 25936799 DOI: 10.1016/J.Chom.2015.04.001 |
0.368 |
|
| 2015 |
Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G. Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury. Immunity. 42: 744-55. PMID 25862092 DOI: 10.1016/J.Immuni.2015.03.004 |
0.375 |
|
| 2015 |
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M, Núñez G, Silverman RH. RNase L activates the NLRP3 inflammasome during viral infections. Cell Host & Microbe. 17: 466-77. PMID 25816776 DOI: 10.1016/J.Chom.2015.02.010 |
0.335 |
|
| 2015 |
Tolle L, Yu FS, Kovach MA, Ballinger MN, Newstead MW, Zeng X, Nunez G, Standiford TJ. Redundant and cooperative interactions between TLR5 and NLRC4 in protective lung mucosal immunity against Pseudomonas aeruginosa. Journal of Innate Immunity. 7: 177-86. PMID 25402425 DOI: 10.1159/000367790 |
0.395 |
|
| 2015 |
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/Cdd.2014.137 |
0.509 |
|
| 2015 |
O'Brien M, Moehring D, Muñoz-Planillo R, Núñez G, Callaway J, Ting J, Scurria M, Ugo T, Bernad L, Cali J, Lazar D. Abstract 1319: Monitoring inflammasome activation with a bioluminescent caspase-1 assay Cancer Research. 75: 1319-1319. DOI: 10.1158/1538-7445.Am2015-1319 |
0.425 |
|
| 2015 |
Fuente MDl, Franchi L, Araya D, Díaz-Jiménez D, Olivares M, Álvarez-Lobos M, Golenbock D, González MJ, López-Kostner F, Quera R, Núñez G, Vidal R, Hermoso MA. Corrigendum to “Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome” [Int. J. Med. Microbiol. 304 (3–4) (2014) 384–392] International Journal of Medical Microbiology. 305: 434. DOI: 10.1016/J.Ijmm.2015.03.007 |
0.303 |
|
| 2015 |
Banerjee S, Chakrabarti A, Franchi L, Loo Y, Gale M, Nunez G, Silverman RH. ID: 206: RNase L activates the NLRP3 inflammasome during viral infections Cytokine. 76: 102. DOI: 10.1016/J.Cyto.2015.08.210 |
0.361 |
|
| 2014 |
Bosmann M, Russkamp NF, Strobl B, Roewe J, Balouzian L, Pache F, Radsak MP, van Rooijen N, Zetoune FS, Sarma JV, Núñez G, Müller M, Murray PJ, Ward PA. Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. Journal of Immunology (Baltimore, Md. : 1950). 193: 5668-77. PMID 25348624 DOI: 10.4049/Jimmunol.1302280 |
0.35 |
|
| 2014 |
Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, et al. IKKα negatively regulates ASC-dependent inflammasome activation. Nature Communications. 5: 4977. PMID 25266676 DOI: 10.1038/Ncomms5977 |
0.386 |
|
| 2014 |
Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M, Sanada T, Suzuki T, Tsutsui H, Núñez G, Sasakawa C. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proceedings of the National Academy of Sciences of the United States of America. 111: E4254-63. PMID 25246571 DOI: 10.1073/Pnas.1324021111 |
0.463 |
|
| 2014 |
Franchi L, Eigenbrod T, Muñoz-Planillo R, Ozkurede U, Kim YG, Chakrabarti A, Gale M, Silverman RH, Colonna M, Akira S, Núñez G. Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux. Journal of Immunology (Baltimore, Md. : 1950). 193: 4214-22. PMID 25225670 DOI: 10.4049/Jimmunol.1400582 |
0.41 |
|
| 2014 |
Jing X, Zulfiqar F, Park SY, Núñez G, Dziarski R, Gupta D. Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis. Journal of Immunology (Baltimore, Md. : 1950). 193: 3055-69. PMID 25114103 DOI: 10.4049/Jimmunol.1301548 |
0.398 |
|
| 2014 |
Burberry A, Zeng MY, Ding L, Wicks I, Inohara N, Morrison SJ, Núñez G. Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling. Cell Host & Microbe. 15: 779-91. PMID 24882704 DOI: 10.1016/J.Chom.2014.05.004 |
0.341 |
|
| 2014 |
De la Fuente M, Franchi L, Araya D, Díaz-Jiménez D, Olivares M, Álvarez-Lobos M, Golenbock D, González MJ, López-Kostner F, Quera R, Núñez G, Vidal R, Hermoso MA. Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome. International Journal of Medical Microbiology : Ijmm. 304: 384-92. PMID 24581881 DOI: 10.1016/J.Ijmm.2014.01.002 |
0.35 |
|
| 2014 |
Suzuki S, Franchi L, He Y, Muñoz-Planillo R, Mimuro H, Suzuki T, Sasakawa C, Núñez G. Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ. Plos Pathogens. 10: e1003926. PMID 24516390 DOI: 10.1371/Journal.Ppat.1003926 |
0.474 |
|
| 2014 |
Kamada N, Núñez G. Regulation of the immune system by the resident intestinal bacteria. Gastroenterology. 146: 1477-88. PMID 24503128 DOI: 10.1053/J.Gastro.2014.01.060 |
0.35 |
|
| 2014 |
Kim YG, Udayanga KG, Totsuka N, Weinberg JB, Núñez G, Shibuya A. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. Cell Host & Microbe. 15: 95-102. PMID 24439901 DOI: 10.1016/J.Chom.2013.12.010 |
0.34 |
|
| 2014 |
Nunez G. S-18 : Linking pathogen virulence, the microbiota and immunity Cytokine. 70: 24-25. DOI: 10.1016/J.Cyto.2014.07.238 |
0.352 |
|
| 2014 |
Coll RC, Robertson AAB, Chae JJ, Higgins SC, Dungan LS, Muñoz-Planillo R, Monks BG, Croker DE, Sutton CE, Stutz A, Nunez G, Latz E, Kastner DL, Mills KHG, Masters SL, et al. MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseases Cytokine. 70: 35-35. DOI: 10.1016/J.Cyto.2014.07.037 |
0.395 |
|
| 2013 |
DeSantis DA, Ko CW, Liu Y, Liu X, Hise AG, Nunez G, Croniger CM. Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice. Mediators of Inflammation. 2013: 751374. PMID 24453428 DOI: 10.1155/2013/751374 |
0.364 |
|
| 2013 |
Zhan Y, Chen PJ, Sadler WD, Wang F, Poe S, Núñez G, Eaton KA, Chen GY. Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury. Cancer Research. 73: 7199-210. PMID 24165160 DOI: 10.1158/0008-5472.Can-13-0827 |
0.32 |
|
| 2013 |
Kim DJ, Park JH, Franchi L, Backert S, Núñez G. The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells European Journal of Immunology. 43: 2650-2658. PMID 23818043 DOI: 10.1002/Eji.201243281 |
0.382 |
|
| 2013 |
Muñoz-Planillo R, Kuffa P, Martínez-Colón G, Smith BL, Rajendiran TM, Núñez G. K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 38: 1142-53. PMID 23809161 DOI: 10.1016/J.Immuni.2013.05.016 |
0.381 |
|
| 2013 |
Kamada N, Chen GY, Inohara N, Núñez G. Control of pathogens and pathobionts by the gut microbiota. Nature Immunology. 14: 685-90. PMID 23778796 DOI: 10.1038/Ni.2608 |
0.353 |
|
| 2013 |
Jiao Y, Darzi Y, Tawaratsumida K, Marchesan JT, Hasegawa M, Moon H, Chen GY, Núñez G, Giannobile WV, Raes J, Inohara N. Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity. Cell Host & Microbe. 13: 595-601. PMID 23684310 DOI: 10.1016/J.Chom.2013.04.005 |
0.312 |
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| 2013 |
He Y, Franchi L, Núñez G. The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. European Journal of Immunology. 43: 1147-52. PMID 23401008 DOI: 10.1002/Eji.201243187 |
0.44 |
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| 2013 |
Kamada N, Núñez G. Role of the gut microbiota in the development and function of lymphoid cells. Journal of Immunology (Baltimore, Md. : 1950). 190: 1389-95. PMID 23378581 DOI: 10.4049/Jimmunol.1203100 |
0.356 |
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| 2013 |
Guarner F, Hooper LV, Núñez G. Understanding the microbiota in the midst of Renaissance architecture and olive groves. Nature Immunology. 14: 101-5. PMID 23334821 DOI: 10.1038/Ni.2512 |
0.311 |
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| 2013 |
Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, Gaillot O, Schreiber S, Lemoine Y, Ryffel B, Hot D, et al. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. The Journal of Clinical Investigation. 123: 700-11. PMID 23281400 DOI: 10.1172/Jci62236 |
0.318 |
|
| 2013 |
Núñez G, VanHook AM. Science Signaling Podcast: 15 January 2013 Science Signaling. 6. DOI: 10.1126/Scisignal.2003894 |
0.317 |
|
| 2012 |
He Y, Franchi L, Núñez G. TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo. Journal of Immunology (Baltimore, Md. : 1950). 190: 334-9. PMID 23225887 DOI: 10.4049/Jimmunol.1202737 |
0.388 |
|
| 2012 |
Marchesan JT, Morelli T, Lundy SK, Jiao Y, Lim S, Inohara N, Nunez G, Fox DA, Giannobile WV. Divergence of the systemic immune response following oral infection with distinct strains of Porphyromonas gingivalis. Molecular Oral Microbiology. 27: 483-95. PMID 23134613 DOI: 10.1111/Omi.12001 |
0.372 |
|
| 2012 |
Franchi L, Núñez G. Immunology. Orchestrating inflammasomes. Science. 337: 1299-1300. PMID 22984056 DOI: 10.1126/Science.1229010 |
0.356 |
|
| 2012 |
Hasegawa M, Kamada N, Jiao Y, Liu MZ, Núñez G, Inohara N. Protective Role of Commensals against Clostridium difficile Infection via an IL-1β–Mediated Positive-Feedback Loop Journal of Immunology. 189: 3085-3091. PMID 22888139 DOI: 10.4049/Jimmunol.1200821 |
0.384 |
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| 2012 |
Nakamura Y, Franchi L, Kambe N, Meng G, Strober W, Núñez G. Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity. 37: 85-95. PMID 22819042 DOI: 10.1016/J.Immuni.2012.04.013 |
0.368 |
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| 2012 |
Homer CR, Kabi A, Marina-García N, Sreekumar A, Nesvizhskii AI, Nickerson KP, Chinnaiyan AM, Nuñez G, McDonald C. A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy. The Journal of Biological Chemistry. 287: 25565-76. PMID 22665475 DOI: 10.1074/Jbc.M111.326835 |
0.567 |
|
| 2012 |
Franchi L, Muñoz-Planillo R, Núñez G. Sensing and reacting to microbes through the inflammasomes Nature Immunology. 13: 325-332. PMID 22430785 DOI: 10.1038/Ni.2231 |
0.473 |
|
| 2012 |
Richmond AL, Kabi A, Homer CR, Marina-García N, Nickerson KP, Nesvizhskii AI, Sreekumar A, Chinnaiyan AM, Nuñez G, McDonald C. The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology. 142: 1483-92.e6. PMID 22387394 DOI: 10.1053/J.Gastro.2012.02.040 |
0.512 |
|
| 2012 |
Liu M, Wang F, Shaw M, Nunez G, Chen GY. Abstract 532: Nod1 functions in T cells to suppress inflammation-associated colorectal cancer Cancer Research. 72: 532-532. DOI: 10.1158/1538-7445.Am2012-532 |
0.35 |
|
| 2012 |
Richmond AL, Kabi A, Homer CR, Nickerson KP, Nesvizhskii AI, Sreekumar A, Chinnaiyan A, Nunez G, McDonald C. 360 CAD, a Nucleotide Synthesis Enzyme, Inhibits NOD2 Anti-Bacterial Function in Human Intestinal Epithelial Cells Gastroenterology. 142: S-85. DOI: 10.1016/S0016-5085(12)60321-7 |
0.541 |
|
| 2011 |
Anand PK, Tait SW, Lamkanfi M, Amer AO, Nunez G, Pagès G, Pouysségur J, McGargill MA, Green DR, Kanneganti TD. TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. The Journal of Biological Chemistry. 286: 42981-91. PMID 22033934 DOI: 10.1074/Jbc.M111.310599 |
0.417 |
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| 2011 |
Chen GY, Núñez G. Inflammasomes in Intestinal Inflammation and Cancer Gastroenterology. 141: 1986-1999. PMID 22005480 DOI: 10.1053/J.Gastro.2011.10.002 |
0.457 |
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| 2011 |
Núñez G. Intracellular sensors of microbes and danger. Immunological Reviews. 243: 5-8. PMID 21884163 DOI: 10.1111/J.1600-065X.2011.01058.X |
0.322 |
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| 2011 |
Franchi L, Núñez G. A New Twist in the Regulation of Legionella Replication through ASC and Caspase-1. Frontiers in Microbiology. 2: 57-57. PMID 21833313 DOI: 10.3389/Fmicb.2011.00057 |
0.478 |
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| 2011 |
Franchi L, Núñez G. A New Twist on the PYRIN Mediterranean Coast Immunity. 34: 695-697. PMID 21616439 DOI: 10.1016/J.Immuni.2011.05.004 |
0.363 |
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| 2011 |
Franchi L, Kamada N, Nunez G. The activation of the NLRC4 inflammasome by pathogenic bacteria breaks intestinal phagocytic cells anergy and promotes host defense: P-181. Inflammatory Bowel Diseases. 17. DOI: 10.1097/00054725-201112002-00215 |
0.368 |
|
| 2010 |
Rastogi R, Du W, Ju D, Pirockinaite G, Liu Y, Nunez G, Samavati L. Dysregulation of p38 and MKP-1 in response to NOD1/TLR4 stimulation in sarcoid bronchoalveolar cells. American Journal of Respiratory and Critical Care Medicine. 183: 500-10. PMID 20851927 DOI: 10.1164/rccm.201005-0792OC |
0.309 |
|
| 2010 |
Franchi L, Nuñez G. AIM2 Joins the Gang of Microbial Sensors Cell Host & Microbe. 7: 340-341. PMID 20478535 DOI: 10.1016/J.Chom.2010.05.002 |
0.305 |
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| 2010 |
Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Núñez G, Suzuki T. Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. Journal of Immunology (Baltimore, Md. : 1950). 184: 5287-97. PMID 20348425 DOI: 10.4049/Jimmunol.0903536 |
0.442 |
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| 2010 |
Franchi L, Muñoz-Planillo R, Reimer T, Eigenbrod T, Núñez G. Inflammasomes as microbial sensors European Journal of Immunology. 40: 611-615. PMID 20201013 DOI: 10.1002/Eji.200940180 |
0.397 |
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| 2010 |
Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. Journal of Immunology (Baltimore, Md. : 1950). 184: 3326-30. PMID 20200276 DOI: 10.4049/Jimmunol.0904189 |
0.368 |
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| 2010 |
Reimer T, Shaw MH, Franchi L, Coban C, Ishii KJ, Akira S, Horii T, Rodriguez A, Núñez G. Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome European Journal of Immunology. 40: 764-769. PMID 19950187 DOI: 10.1002/Eji.200939996 |
0.365 |
|
| 2009 |
Franchi L, Chen G, Marina-Garcia N, Abe A, Qu Y, Bao S, Shayman JA, Turk J, Dubyak GR, Núñez G. Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone. Journal of Innate Immunity. 1: 607-17. PMID 20160900 DOI: 10.1159/000227263 |
0.393 |
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| 2009 |
Harder J, Franchi L, Muñoz-Planillo R, Park JH, Reimer T, Núñez G. Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-κB activation but proceeds independently of TLR signaling and P2X7 receptor Journal of Immunology. 183: 5823-5829. PMID 19812205 DOI: 10.4049/Jimmunol.0900444 |
0.455 |
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| 2009 |
Muñoz-Planillo R, Franchi L, Miller LS, Núñez G. A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome. Journal of Immunology (Baltimore, Md. : 1950). 183: 3942-8. PMID 19717510 DOI: 10.4049/jimmunol.0900729 |
0.309 |
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| 2009 |
Chu J, Thomas LM, Watkins SC, Franchi L, Núñez G, Salter RD. Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner. Journal of Leukocyte Biology. 86: 1227-38. PMID 19675207 DOI: 10.1189/Jlb.0309164 |
0.352 |
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| 2009 |
Ozören N, Inohara N, Núñez G. A putative role for human BFK in DNA damage-induced apoptosis. Biotechnology Journal. 4: 1046-54. PMID 19557800 DOI: 10.1002/Biot.200900091 |
0.712 |
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| 2009 |
Franchi L, Eigenbrod T, Núñez G. Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation Journal of Immunology. 183: 792-796. PMID 19542372 DOI: 10.4049/Jimmunol.0900173 |
0.415 |
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| 2009 |
Chen GY, Núñez G. Gut Immunity: a NOD to the commensals. Current Biology. 19. PMID 19243695 DOI: 10.1016/J.Cub.2008.12.027 |
0.342 |
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| 2009 |
Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nature Immunology. 10: 241-7. PMID 19221555 DOI: 10.1038/ni.1703 |
0.345 |
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| 2009 |
Park JH, Kim YG, Núñez G. RICK promotes inflammation and lethality after gram-negative bacterial infection in mice stimulated with lipopolysaccharide Infection and Immunity. 77: 1569-1578. PMID 19188356 DOI: 10.1128/IAI.01505-08 |
0.335 |
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| 2009 |
Chen G, Shaw MH, Kim YG, Nuñez G. NOD-like receptors: Role in innate immunity and inflammatory disease Annual Review of Pathology: Mechanisms of Disease. 4: 365-398. PMID 18928408 DOI: 10.1146/annurev.pathol.4.110807.092239 |
0.316 |
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| 2008 |
Eigenbrod T, Park JH, Harder J, Iwakura Y, Núñez G. Cutting edge: Critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1α released from dying cells Journal of Immunology. 181: 8194-8198. PMID 19050234 DOI: 10.4049/Jimmunol.181.12.8194 |
0.364 |
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| 2008 |
Kim YG, Park JH, Daignault S, Fukase K, Núñez G. Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages Journal of Immunology. 181: 4340-4346. PMID 18768892 DOI: 10.4049/JIMMUNOL.181.6.4340 |
0.312 |
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| 2008 |
Franchi L, Núñez G. The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activity European Journal of Immunology. 38: 2085-2089. PMID 18624356 DOI: 10.1002/Eji.200838549 |
0.426 |
|
| 2008 |
Shaw MH, Reimer T, Kim YG, Nuñez G. NOD-like receptors (NLRs): bona fide intracellular microbial sensors Current Opinion in Immunology. 20: 377-382. PMID 18585455 DOI: 10.1016/J.Coi.2008.06.001 |
0.424 |
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| 2008 |
Moreira LO, El Kasmi KC, Smith AM, Finkelstein D, Fillon S, Kim YG, Núñez G, Tuomanen E, Murray PJ. The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls. Cellular Microbiology. 10: 2067-77. PMID 18549453 DOI: 10.1111/J.1462-5822.2008.01189.X |
0.331 |
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| 2008 |
Marina-García N, Franchi L, Kim YG, Miller D, McDonald C, Boons GJ, Núñez G. Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. Journal of Immunology (Baltimore, Md. : 1950). 180: 4050-7. PMID 18322214 |
0.599 |
|
| 2008 |
Franchi L, Park JH, Shaw MH, Marina-Garcia N, Chen G, Kim YG, Núñez G. Intracellular NOD-like receptors in innate immunity, infection and disease Cellular Microbiology. 10: 1-8. PMID 17944960 DOI: 10.1111/J.1462-5822.2007.01059.X |
0.428 |
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| 2007 |
Franchi L, Stoolman J, Kanneganti TD, Verma A, Ramphal R, Núñez G. Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. European Journal of Immunology. 37: 3030-9. PMID 17935074 DOI: 10.1002/eji.200737532 |
0.358 |
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| 2007 |
Suzuki T, Núñez G. A role for Nod-like receptors in autophagy induced by Shigella infection. Autophagy. 4: 73-5. PMID 17932464 DOI: 10.4161/auto.5101 |
0.352 |
|
| 2007 |
Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, Nuñez G. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. Plos Pathogens. 3: e111. PMID 17696608 DOI: 10.1371/journal.ppat.0030111 |
0.342 |
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| 2007 |
Qu Y, Franchi L, Nunez G, Dubyak GR. Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. Journal of Immunology (Baltimore, Md. : 1950). 179: 1913-25. PMID 17641058 DOI: 10.4049/Jimmunol.179.3.1913 |
0.363 |
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| 2007 |
Park JH, Kim YG, Shaw M, Kanneganti TD, Fujimoto Y, Fukase K, Inohara N, Núñez G. Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells Journal of Immunology. 179: 514-521. PMID 17579072 |
0.313 |
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| 2007 |
Lamkanfi M, Amer A, Kanneganti TD, Muñoz-Planillo R, Chen G, Vandenabeele P, Fortier A, Gros P, Núñez G. The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. Journal of Immunology (Baltimore, Md. : 1950). 178: 8022-7. PMID 17548639 DOI: 10.4049/Jimmunol.178.12.8022 |
0.352 |
|
| 2007 |
Franchi L, Kanneganti TD, Dubyak GR, Núñez G. Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. The Journal of Biological Chemistry. 282: 18810-8. PMID 17491021 DOI: 10.1074/Jbc.M610762200 |
0.433 |
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| 2007 |
Lamkanfi M, Kanneganti TD, Franchi L, Núñez G. Caspase-1 inflammasomes in infection and inflammation Journal of Leukocyte Biology. 82: 220-225. PMID 17442855 DOI: 10.1189/Jlb.1206756 |
0.432 |
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| 2007 |
Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L, Vandenabeele P, Núñez G. Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling Immunity. 26: 433-443. PMID 17433728 DOI: 10.1016/j.immuni.2007.03.008 |
0.337 |
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| 2007 |
Lécine P, Esmiol S, Métais JY, Nicoletti C, Nourry C, McDonald C, Nunez G, Hugot JP, Borg JP, Ollendorff V. The NOD2-RICK complex signals from the plasma membrane. The Journal of Biological Chemistry. 282: 15197-207. PMID 17355968 DOI: 10.1074/Jbc.M606242200 |
0.53 |
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| 2007 |
Park JH, Kim YG, McDonald C, Kanneganti TD, Hasegawa M, Body-Malapel M, Inohara N, Núñez G. RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs Journal of Immunology. 178: 2380-2386. PMID 17277144 DOI: 10.4049/Jimmunol.178.4.2380 |
0.565 |
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| 2007 |
Manon F, Favier A, Núñez G, Simorre JP, Cusack S. Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. Journal of Molecular Biology. 365: 160-74. PMID 17054981 DOI: 10.1016/J.Jmb.2006.09.067 |
0.365 |
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| 2007 |
Zilbauer M, Dorrell N, Elmi A, Lindley K, Schuller S, Jones H, Klein N, Nunez G, Wren B, Bajaj-Elliott M. A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni (vol 9, pg 2404, 2007) Cellular Microbiology. 9. DOI: 10.1111/J.1462-5822.2007.01008.X |
0.35 |
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| 2006 |
Kanneganti TD, Body-Malapel M, Amer A, Park JH, Whitfield J, Franchi L, Taraporewala ZF, Miller D, Patton JT, Inohara N, Núñez G. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA Journal of Biological Chemistry. 281: 36560-36568. PMID 17008311 DOI: 10.1074/Jbc.M607594200 |
0.311 |
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| 2006 |
Amer A, Franchi L, Kanneganti TD, Body-Malapel M, Ozören N, Brady G, Meshinchi S, Jagirdar R, Gewirtz A, Akira S, Núñez G. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. The Journal of Biological Chemistry. 281: 35217-23. PMID 16984919 DOI: 10.1074/Jbc.M604933200 |
0.738 |
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| 2006 |
Franchi L, McDonald C, Kanneganti TD, Amer A, Núñez G. Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense. Journal of Immunology (Baltimore, Md. : 1950). 177: 3507-13. PMID 16951308 DOI: 10.4049/Jimmunol.177.6.3507 |
0.612 |
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| 2006 |
Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozören N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Núñez G. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nature Immunology. 7: 576-82. PMID 16648852 DOI: 10.1038/Ni1346 |
0.751 |
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| 2006 |
Ozören N, Masumoto J, Franchi L, Kanneganti TD, Body-Malapel M, Ertürk I, Jagirdar R, Zhu L, Inohara N, Bertin J, Coyle A, Grant EP, Núñez G. Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. Journal of Immunology (Baltimore, Md. : 1950). 176: 4337-42. PMID 16547271 DOI: 10.4049/Jimmunol.176.7.4337 |
0.747 |
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| 2006 |
Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, Fujimoto Y, Kawasaki A, Foster SJ, Horie Y, Mak TW, Núñez G, Chinnaiyan AM, Fukase K, Inohara N. Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. Journal of Experimental Medicine. 203: 203-213. PMID 16418393 DOI: 10.1084/Jem.20051229 |
0.428 |
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| 2006 |
Kanneganti TD, Ozören N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Núñez G. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature. 440: 233-6. PMID 16407888 DOI: 10.1038/Nature04517 |
0.748 |
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| 2006 |
Franchi L, Özören N, Body-Malapel M, Jagirdar R, Núñez G. Cytosolic Recognition of Intracellular Bacteria by ASC and Ipaf Overcomes Endotoxin Tolerance Through Induction of Potent IL-1β Secretion Inflammatory Bowel Diseases. 12. DOI: 10.1097/00054725-200604002-00043 |
0.717 |
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| 2005 |
McDonald C, Chen FF, Ollendorff V, Ogura Y, Marchetto S, Lécine P, Borg JP, Nuñez G. A role for Erbin in the regulation of Nod2-dependent NF-κB signaling Journal of Biological Chemistry. 280: 40301-40309. PMID 16203728 DOI: 10.1074/Jbc.M508538200 |
0.624 |
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| 2005 |
Karl E, Warner K, Zeitlin B, Kaneko T, Wurtzel L, Jin T, Chang J, Wang S, Wang CY, Strieter RM, Nunez G, Polverini PJ, Nör JE. Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines. Cancer Research. 65: 5063-9. PMID 15958549 DOI: 10.1158/0008-5472.Can-05-0140 |
0.336 |
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| 2005 |
Inohara N, Chamaillard M, McDonald C, Nuñez G. NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease Annual Review of Biochemistry. 74: 355-383. PMID 15952891 DOI: 10.1146/Annurev.Biochem.74.082803.133347 |
0.632 |
|
| 2005 |
McDonald CL, Inohara N, Nuñez G. Peptidoglycan Signaling in Innate Immunity and Inflammatory Disease Journal of Biological Chemistry. 280: 20177-20180. PMID 15802263 DOI: 10.1074/Jbc.R500001200 |
0.614 |
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| 2005 |
Suzuki T, Nakanishi K, Tsutsui H, Iwai H, Akira S, Inohara N, Chamaillard M, Nuñez G, Sasakawa C. A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages. The Journal of Biological Chemistry. 280: 14042-50. PMID 15695506 DOI: 10.1074/jbc.M414671200 |
0.323 |
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| 2005 |
Chamaillard M, McDonald C, Nuñez G. Early-onset sarcoidosis gets the nod Blood. 105: 912-912. DOI: 10.1182/Blood-2004-11-4289 |
0.501 |
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| 2004 |
Czerski L, Nuñez G. Apoptosome formation and caspase activation: is it different in the heart? Journal of Molecular and Cellular Cardiology. 37: 643-652. PMID 15350837 DOI: 10.1016/J.Yjmcc.2004.04.016 |
0.385 |
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| 2004 |
Dowds TA, Masumoto J, Zhu L, Inohara N, Núñez G. Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. The Journal of Biological Chemistry. 279: 21924-8. PMID 15020601 DOI: 10.1074/Jbc.M401178200 |
0.41 |
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| 2004 |
McDonald CL, Nuñez G. Mindin the fort. Nature Immunology. 5: 16-18. PMID 14699402 DOI: 10.1038/Ni0104-16 |
0.535 |
|
| 2003 |
Tang ED, Inohara N, Wang CY, Nuñez G, Guan KL. Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. The Journal of Biological Chemistry. 278: 38566-70. PMID 12890679 DOI: 10.1074/Jbc.M304374200 |
0.346 |
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| 2003 |
Inohara N, Nuñez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nature Reviews. Immunology. 3: 371-82. PMID 12766759 DOI: 10.1038/nri1086 |
0.306 |
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| 2003 |
Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Núñez G, Inohara N. ASC is an activating adaptor for NF-κB and caspase-8-dependent apoptosis Biochemical and Biophysical Research Communications. 303: 69-73. PMID 12646168 DOI: 10.1016/S0006-291X(03)00309-7 |
0.384 |
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| 2003 |
Masumoto J, Zhou W, Chen FF, Su F, Kuwada JY, Hidaka E, Katsuyama T, Sagara J, Taniguchi S, Ngo-Hazelett P, Postlethwait JH, Núñez G, Inohara N. Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development. The Journal of Biological Chemistry. 278: 4268-76. PMID 12464617 DOI: 10.1074/Jbc.M203944200 |
0.399 |
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| 2002 |
Gutierrez O, Pipaon C, Inohara N, Fontalba A, Ogura Y, Prosper F, Nuñez G, Fernandez-Luna JL. Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation Journal of Biological Chemistry. 277: 41701-41705. PMID 12194982 DOI: 10.1074/Jbc.M206473200 |
0.395 |
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| 2002 |
Muto A, Ruland J, McAllister-Lucas LM, Lucas PC, Yamaoka S, Chen FF, Lin A, Mak TW, Núñez G, Inohara N. Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester. The Journal of Biological Chemistry. 277: 31871-6. PMID 12091384 DOI: 10.1074/Jbc.M202222200 |
0.332 |
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| 2002 |
Inohara N, Ogura Y, Nuñez G. Nods: a family of cytosolic proteins that regulate the host response to pathogens. Current Opinion in Microbiology. 5: 76-80. PMID 11834373 DOI: 10.1016/S1369-5274(02)00289-8 |
0.41 |
|
| 2001 |
Inohara N, Nuñez G. The NOD: a signaling module that regulates apoptosis and host defense against pathogens. Oncogene. 20: 6473-6481. PMID 11607846 DOI: 10.1038/Sj.Onc.1204787 |
0.407 |
|
| 2001 |
McAllister-Lucas LM, Inohara N, Lucas PC, Ruland J, Benito A, Li Q, Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW, Núñez G. Bimp1, a MAGUK Family Member Linking Protein Kinase C Activation to Bcl10-mediated NF-κB Induction Journal of Biological Chemistry. 276: 30589-30597. PMID 11387339 DOI: 10.1074/Jbc.M103824200 |
0.371 |
|
| 2001 |
Nickerson K, Sisk TJ, Inohara N, Yee CS, Kennell J, Cho MC, Yannie PJ, Nunez G, Chang CH. Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activity. The Journal of Biological Chemistry. 276: 19089-93. PMID 11279191 DOI: 10.1074/Jbc.M101295200 |
0.32 |
|
| 2001 |
Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF, Yamaoka S, Seto M, Nunez G. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway. The Journal of Biological Chemistry. 276: 19012-9. PMID 11262391 DOI: 10.1074/Jbc.M009984200 |
0.37 |
|
| 2000 |
Inohara N, Koseki T, Lin J, Peso LD, Lucas PC, Chen FF, Ogura Y, Núñez G. An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways Journal of Biological Chemistry. 275: 27823-27831. PMID 10880512 DOI: 10.1074/Jbc.M003415200 |
0.366 |
|
| 2000 |
Sanz C, Benito A, Inohara N, Ekhterae D, Nunez G, Fernandez-Luna JL. Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells Blood. 95: 2742-2747. DOI: 10.1182/Blood.V95.9.2742.009K24_2742_2747 |
0.349 |
|
| 1999 |
Tsukahara T, Kannagi M, Ohashi T, Kato H, Arai M, Nunez G, Iwanaga Y, Yamamoto N, Ohtani K, Nakamura M, Fujii M. Induction of Bcl-xL Expression by Human T-Cell Leukemia Virus Type 1 Tax through NF-κB in Apoptosis-Resistant T-Cell Transfectants with Tax Journal of Virology. 73: 7981-7987. PMID 10482545 DOI: 10.1128/Jvi.73.10.7981-7987.1999 |
0.403 |
|
| 1999 |
Silva M, Benito A, Sanz C, Prosper F, Ekhterae D, Nuñez G, Fernandez-Luna JL. Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines. Journal of Biological Chemistry. 274: 22165-22169. PMID 10428780 DOI: 10.1074/Jbc.274.32.22165 |
0.385 |
|
| 1999 |
Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. The Journal of Biological Chemistry. 274: 14560-7. PMID 10329646 DOI: 10.1074/Jbc.274.21.14560 |
0.396 |
|
| 1999 |
Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottiger MO, Nabel GJ, Núñez G. CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. The Journal of Biological Chemistry. 274: 9955-61. PMID 10187770 DOI: 10.1074/Jbc.274.15.9955 |
0.373 |
|
| 1998 |
del Peso L, González VM, Núñez G. Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. The Journal of Biological Chemistry. 273: 33495-500. PMID 9837929 DOI: 10.1074/Jbc.273.50.33495 |
0.384 |
|
| 1998 |
Inohara N, Gourley TS, Carrio R, Muñiz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Núñez G. Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3- independent cell death Journal of Biological Chemistry. 273: 32479-32486. PMID 9829980 DOI: 10.1074/Jbc.273.49.32479 |
0.369 |
|
| 1998 |
Liu JR, Fletcher B, Page C, Hu C, Nunez G, Baker V. Bcl-xLIs Expressed in Ovarian Carcinoma and Modulates Chemotherapy-Induced Apoptosis Gynecologic Oncology. 70: 398-403. PMID 9790794 DOI: 10.1006/Gyno.1998.5125 |
0.313 |
|
| 1998 |
Han J, Wallen HD, Nuñez G, White E. E1B 19,000-Molecular-Weight Protein Interacts with and Inhibits CED-4-Dependent, FLICE-Mediated Apoptosis Molecular and Cellular Biology. 18: 6052-6062. PMID 9742122 DOI: 10.1128/Mcb.18.10.6052 |
0.339 |
|
| 1998 |
Packham G, White EL, Eischen CM, Yang H, Parganas E, Ihle JN, Grillot DA, Zambetti GP, Nuñez G, Cleveland JL. Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies. Genes & Development. 12: 2475-87. PMID 9716401 DOI: 10.1101/Gad.12.16.2475 |
0.399 |
|
| 1998 |
Han JS, Núñez G, Wicha MS, Clarke MF. Targeting cancer cell death with a bcl-XS adenovirus. Springer Seminars in Immunopathology. 19: 279-88. PMID 9580270 DOI: 10.1007/Bf00787225 |
0.33 |
|
| 1998 |
Stoll SW, Benedict M, Mitra R, Hiniker A, Elder JT, Nuñez G. EGF receptor signaling inhibits keratinocyte apoptosis: Evidence for mediation by Bcl-XL Oncogene. 16: 1493-1499. PMID 9580112 DOI: 10.1038/Sj.Onc.1201657 |
0.322 |
|
| 1998 |
Inohara N, Peso Ld, Koseki T, Chen S, Núñez G. RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis Journal of Biological Chemistry. 273: 12296-12300. PMID 9575181 DOI: 10.1074/Jbc.273.20.12296 |
0.372 |
|
| 1998 |
Hu Y, Benedict MA, Wu D, Inohara N, Núñez G. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation Proceedings of the National Academy of Sciences of the United States of America. 95: 4386-4391. PMID 9539746 DOI: 10.1073/Pnas.95.8.4386 |
0.391 |
|
| 1998 |
Inohara N, Ekhterae D, Garcia I, Carrio R, Merino J, Merry A, Chen S, Núñez G. Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL Journal of Biological Chemistry. 273: 8705-8710. PMID 9535847 DOI: 10.1074/Jbc.273.15.8705 |
0.365 |
|
| 1998 |
Solvason N, Wu WW, Kabra N, Lund-Johansen F, Roncarolo MG, Behrens TW, Grillot DA, Nunez G, Lees E, Howard M. Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells. The Journal of Experimental Medicine. 187: 1081-91. PMID 9529324 DOI: 10.1084/Jem.187.7.1081 |
0.354 |
|
| 1998 |
Petschner F, Zimmerman C, Strasser A, Grillot D, Nunez G, Pircher H. Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection. European Journal of Immunology. 28: 560-9. PMID 9521066 DOI: 10.1002/(Sici)1521-4141(199802)28:02<560::Aid-Immu560>3.0.Co;2-Q |
0.334 |
|
| 1998 |
Akifusa S, Ohguchi M, Koseki T, Nara K, Semba I, Yamato K, Okahashi N, Merino R, Núñez G, Hanada N, Takehara T, Nishihara T. Increase In Bcl-2 Level Promoted By Cd40 Ligation Correlates With Inhibition Of B Cell Apoptosis Induced By Vacuolar Type H+-Atpase Inhibitor Experimental Cell Research. 238: 82-89. PMID 9457059 DOI: 10.1006/Excr.1997.3848 |
0.35 |
|
| 1997 |
Inohara N, Koseki T, Hu Y, Chen S, Núñez G. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis Proceedings of the National Academy of Sciences of the United States of America. 94: 10717-10722. PMID 9380701 DOI: 10.1073/Pnas.94.20.10717 |
0.37 |
|
| 1997 |
Simonian PL, Grillot DAM, Nuñez G. Bak can accelerate chemotherapy-induced cell death independently of its heterodimerization with Bcl-XL and Bcl-2. Oncogene. 15: 1871-1875. PMID 9362454 DOI: 10.1038/Sj.Onc.1201350 |
0.327 |
|
| 1997 |
Wu D, Wallen HD, Inohara N, Nuñez G. Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9 Journal of Biological Chemistry. 272: 21449-21454. PMID 9261161 DOI: 10.1074/Jbc.272.34.21449 |
0.399 |
|
| 1997 |
Bojes HK, Datta K, Xu J, Chin A, Simonian P, Nuñez G, Kehrer JP. Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal The Biochemical Journal. 325. PMID 9230108 DOI: 10.1042/Bj3250315 |
0.39 |
|
| 1997 |
Inohara N, Ding L, Chen S, Núñez G. harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X L The Embo Journal. 16: 1686-1694. PMID 9130713 DOI: 10.1093/Emboj/16.7.1686 |
0.383 |
|
| 1997 |
Simonian PL, Grillot DAM, Nuñez G. Bcl-2 and Bcl-XL Can Differentially Block Chemotherapy-Induced Cell Death Blood. 90: 1208-1216. DOI: 10.1182/Blood.V90.3.1208.1208_1208_1216 |
0.34 |
|
| 1996 |
Nuñez G, Merino R, Simonian PL, Grillot DAM. REGULATION OF LYMPHOID APOPTOSIS BY Bcl-2 AND Bcl-xL Advances in Experimental Medicine and Biology. 406: 75-82. PMID 8910673 DOI: 10.1007/978-1-4899-0274-0_8 |
0.389 |
|
| 1996 |
Simonian PL, Grillot DAM, Merino R, Nuñez G. Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL Journal of Biological Chemistry. 271: 22764-22772. PMID 8798452 DOI: 10.1074/Jbc.271.37.22764 |
0.376 |
|
| 1996 |
Heermeier K, Benedict M, Li M, Furth P, Nuñez G, Hennighausen L. Bax and Bcl-xS are induced at the onset of apoptosis in involuting mammary epithelial cells Mechanisms of Development. 56: 197-207. PMID 8798158 DOI: 10.1016/0925-4773(96)88032-4 |
0.309 |
|
| 1996 |
López-Hoyos M, Carrió R, Merino R, Buelta L, Izui S, Núñez G, Merino J. Constitutive expression of bcl-2 in B cells causes a lethal form of lupuslike autoimmune disease after induction of neonatal tolerance to H-2b alloantigens. Journal of Experimental Medicine. 183: 2523-2531. PMID 8676073 DOI: 10.1084/Jem.183.6.2523 |
0.333 |
|
| 1996 |
Silva M, Grillot D, Benito A, Richard C, Nunez G, Fernandez-Luna JL. Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2 Blood. 88: 1576-1582. DOI: 10.1182/Blood.V88.5.1576.Bloodjournal8851576 |
0.357 |
|
| 1996 |
Benito A, Silva M, Grillot D, Nuñez G, Fernández-Luna JL. Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL Blood. 87: 3837-3843. DOI: 10.1182/Blood.V87.9.3837.Bloodjournal8793837 |
0.349 |
|
| 1995 |
Clarke MF, Apel IJ, Benedict MA, Eipers PG, Sumantran V, González-García M, Doedens M, Fukunaga N, Davidson B, Dick JE, Minn AJ, Boise LH, Thompson CB, Wicha M, Núñez G. A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 11024-8. PMID 7479929 DOI: 10.1073/Pnas.92.24.11024 |
0.317 |
|
| 1994 |
Gottschalk AR, Mcshan CL, Merino R, Nuñez G, Quintáns J. Physiological cell death in B lymphocytes: I. Differential susceptibility of WEHI-231 sublines to anti-lg inducedphysiological cell death and lack of correlation with bcl-2 expression International Immunology. 6: 121-130. PMID 8148321 DOI: 10.1093/Intimm/6.1.121 |
0.339 |
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