| Year |
Citation |
Score |
| 2022 |
Sun J, Zhao G, Bylund T, Lee M, Adibhatla S, Kwong PD, Chuang GY, Rawi R, Bewley CA. -Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity. Acs Chemical Biology. PMID 35537058 DOI: 10.1021/acschembio.1c00990 |
0.31 |
|
| 2018 |
Zhou T, Zheng A, Baxa U, Chuang GY, Georgiev IS, Kong R, O'Dell S, Shahzad-Ul-Hussan S, Shen CH, Tsybovsky Y, Bailer RT, Gift SK, Louder MK, McKee K, Rawi R, ... ... Bewley CA, et al. A Neutralizing Antibody Recognizing Primarily N-linked Glycan Targets the Silent Face of the HIV Envelope. Immunity. PMID 29548671 DOI: 10.1016/J.Immuni.2018.02.013 |
0.346 |
|
| 2017 |
Bobyk KD, Mandadapu SR, Lohith K, Guzzo C, Bhargava A, Lusso P, Bewley CA. Design of HIV co-receptor derived peptides that inhibit viral entry at submicromolar concentrations. Molecular Pharmaceutics. PMID 28494151 DOI: 10.1021/Acs.Molpharmaceut.7B00155 |
0.38 |
|
| 2017 |
Shahzad-Ul-Hussan S, Sastry M, Lemmin T, Soto C, Loesgen S, Scott DA, Davison JR, O'Connor R, Kwong PD, Bewley CA. NMR insights into the conformational properties of Man-9 and its recognition by two HIV binding proteins. Chembiochem : a European Journal of Chemical Biology. PMID 28166380 DOI: 10.1002/Cbic.201600665 |
0.375 |
|
| 2016 |
Lusvarghi S, Bewley CA. Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential. Viruses. 8. PMID 27783038 DOI: 10.3390/V8100296 |
0.341 |
|
| 2016 |
Lusvarghi S, Lohith KM, Morin-Leisk J, Ghirlando R, Hinshaw JE, Bewley CA. Binding site geometry and subdomain valency control effects of neutralizing lectins on HIV-1 viral particles. Acs Infectious Diseases. PMID 27669574 DOI: 10.1021/Acsinfecdis.6B00139 |
0.334 |
|
| 2016 |
Stewart-Jones GB, Soto C, Lemmin T, Chuang GY, Druz A, Kong R, Thomas PV, Wagh K, Zhou T, Behrens AJ, Bylund T, Choi CW, Davison JR, Georgiev IS, Joyce MG, ... ... Bewley CA, et al. Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. Cell. PMID 27114034 DOI: 10.1016/J.Cell.2016.04.010 |
0.366 |
|
| 2016 |
Mason RD, Welles HC, Adams C, Chakrabarti BK, Gorman J, Zhou T, Nguyen R, O'Dell S, Lusvarghi S, Bewley CA, Li H, Shaw GM, Sheng Z, Shapiro L, Wyatt R, et al. Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability. Plos Pathogens. 12: e1005537. PMID 27064278 DOI: 10.1371/Journal.Ppat.1005537 |
0.379 |
|
| 2016 |
Dogo-Isonagie C, Lee SL, Lohith K, Liu H, Mandadapu SR, Lusvarghi S, O'Connor RD, Bewley CA. Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry. Bioorganic & Medicinal Chemistry. PMID 26968647 DOI: 10.1016/J.Bmc.2016.02.044 |
0.366 |
|
| 2014 |
Louis JM, Aniana A, Lohith K, Sayer JM, Roche J, Bewley CA, Clore GM. Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations. Plos One. 9: e104683. PMID 25105806 DOI: 10.1371/Journal.Pone.0104683 |
0.343 |
|
| 2014 |
Mason R, Adams C, Bewley C, Mascola J, Roederer M. Potent SIV-specific Antibodies Targeting the Cyanovirin Binding Site Aids Research and Human Retroviruses. 30: A211-A212. DOI: 10.1089/Aid.2014.5457C.Abstract |
0.413 |
|
| 2013 |
Pancera M, Shahzad-Ul-Hussan S, Doria-Rose NA, McLellan JS, Bailer RT, Dai K, Loesgen S, Louder MK, Staupe RP, Yang Y, Zhang B, Parks R, Eudailey J, Lloyd KE, Blinn J, ... ... Bewley CA, et al. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nature Structural & Molecular Biology. 20: 804-13. PMID 23708607 DOI: 10.1038/Nsmb.2600 |
0.359 |
|
| 2012 |
Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA. Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. The Journal of Biological Chemistry. 287: 15076-86. PMID 22403408 DOI: 10.1074/Jbc.M111.332361 |
0.338 |
|
| 2012 |
Pancera M, McLellan J, Shahzad-ul-Hussan S, Doria-Rose N, Zhang B, Yang Y, Burton, Koff W, Bewley C, Kwong P. Structural comparison of somatically related PG9 and PG16 in complex with their epitope reveals differences in glycan recognition Retrovirology. 9: 74. DOI: 10.1186/1742-4690-9-S2-P74 |
0.383 |
|
| 2012 |
Sastry M, Xu L, Bhattacharya S, Nabel G, Bewley C, Kwong P. NMR spectroscopy of HIV-1 gp120 outer domain Retrovirology. 9: 20. DOI: 10.1186/1742-4690-9-S2-P20 |
0.359 |
|
| 2012 |
Perera HD, Keffer J, Bewley C. The Mode of Action of FtsZ Inhibitors Biophysical Journal. 102: 64a. DOI: 10.1016/J.Bpj.2011.11.380 |
0.311 |
|
| 2011 |
Acharya P, Dogo-Isonagie C, LaLonde JM, Lam SN, Leslie GJ, Louder MK, Frye LL, Debnath AK, Greenwood JR, Luongo TS, Martin L, Watts KS, Hoxie JA, Mascola JR, Bewley CA, et al. Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry. Acs Chemical Biology. 6: 1069-77. PMID 21793507 DOI: 10.1021/Cb200068B |
0.4 |
|
| 2011 |
Shahzad-ul-Hussan S, Gustchina E, Ghirlando R, Clore GM, Bewley CA. Solution structure of the monovalent lectin microvirin in complex with Man(alpha)(1-2)Man provides a basis for anti-HIV activity with low toxicity. The Journal of Biological Chemistry. 286: 20788-96. PMID 21471192 DOI: 10.1074/Jbc.M111.232678 |
0.399 |
|
| 2010 |
Gustchina E, Li M, Louis JM, Anderson DE, Lloyd J, Frisch C, Bewley CA, Gustchina A, Wlodawer A, Clore GM. Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41. Plos Pathogens. 6: e1001182. PMID 21085615 DOI: 10.1371/Journal.Ppat.1001182 |
0.314 |
|
| 2009 |
Shahzad-ul-Hussan S, Cai M, Bewley CA. Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL. Journal of the American Chemical Society. 131: 16500-8. PMID 19856962 DOI: 10.1021/Ja905929C |
0.362 |
|
| 2009 |
Gustchina E, Louis JM, Frisch C, Ylera F, Lechner A, Bewley CA, Clore GM. Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth. Virology. 393: 112-9. PMID 19695655 DOI: 10.1016/J.Virol.2009.07.019 |
0.375 |
|
| 2008 |
Lam SN, Acharya P, Wyatt R, Kwong PD, Bewley CA. Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry. Bioorganic & Medicinal Chemistry. 16: 10113-20. PMID 18952441 DOI: 10.1016/J.Bmc.2008.10.005 |
0.337 |
|
| 2008 |
Nelson JD, Kinkead H, Brunel FM, Leaman D, Jensen R, Louis JM, Maruyama T, Bewley CA, Bowdish K, Clore GM, Dawson PE, Frederickson S, Mage RG, Richman DD, Burton DR, et al. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics. Virology. 377: 170-83. PMID 18499210 DOI: 10.1016/J.Virol.2008.04.005 |
0.371 |
|
| 2007 |
Plaza A, Gustchina E, Baker HL, Kelly M, Bewley CA. Mirabamides A-D, depsipeptides from the sponge Siliquariaspongia mirabilis that inhibit HIV-1 fusion. Journal of Natural Products. 70: 1753-60. PMID 17963357 DOI: 10.1021/Np070306K |
0.317 |
|
| 2007 |
Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD. Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science (New York, N.Y.). 317: 1930-4. PMID 17901336 DOI: 10.1126/Science.1145373 |
0.358 |
|
| 2007 |
Gustchina E, Louis JM, Lam SN, Bewley CA, Clore GM. A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains. Journal of Virology. 81: 12946-53. PMID 17898046 DOI: 10.1128/Jvi.01260-07 |
0.32 |
|
| 2006 |
Gustchina E, Louis JM, Bewley CA, Clore GM. Synergistic Inhibition of HIV-1 Envelope-Mediated Membrane Fusion by Inhibitors Targeting the N and C-Terminal Heptad Repeats of gp41 Journal of Molecular Biology. 364: 283-289. PMID 17010381 DOI: 10.1016/J.Jmb.2006.09.017 |
0.323 |
|
| 2005 |
Louis JM, Bewley CA, Gustchina E, Aniana A, Clore GM. Characterization and HIV-1 fusion inhibitory properties of monoclonal fabs obtained from a human non-immune phage library selected against diverse epitopes of the ectodomain of HIV-1 gp41 Journal of Molecular Biology. 353: 945-951. PMID 16216270 DOI: 10.1016/J.Jmb.2005.09.044 |
0.359 |
|
| 2005 |
Dimitrov AS, Louis JM, Bewley CA, Clore GM, Blumenthal R. Conformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation Biochemistry. 44: 12471-12479. PMID 16156659 DOI: 10.1021/Bi051092D |
0.403 |
|
| 2005 |
Williams DC, Lee JY, Cai M, Bewley CA, Clore GM. Crystal structures of the HIV-1 inhibitory cyanobacterial protein MVL free and bound to man3GlcNAc2: Structural basis for specificity and high-affinity binding to the core pentasaccharide from N-linked oligomannoside Journal of Biological Chemistry. 280: 29269-29276. PMID 15937331 DOI: 10.1074/Jbc.M504642200 |
0.358 |
|
| 2005 |
Gustchina E, Hummer G, Bewley CA, Clore GM. Differential inhibition of HIV-1 and SIV envelope-mediated cell fusion by C34 peptides derived from the C-terminal heptad repeat of gp41 from diverse strains of HIV-1, HIV-2, and SIV Journal of Medicinal Chemistry. 48: 3036-3044. PMID 15828842 DOI: 10.1021/Jm049026H |
0.333 |
|
| 2004 |
Bewley CA, Ray S, Cohen F, Collins SK, Overman LE. Inhibition of HIV-1 envelope-mediated fusion by synthetic batzelladine analogues. Journal of Natural Products. 67: 1319-24. PMID 15332849 DOI: 10.1021/Np049958O |
0.377 |
|
| 2004 |
Gallo SA, Clore GM, Louis JM, Bewley CA, Blumenthal R. Temperature-dependent intermediates in HIV-1 envelope glycoprotein-mediated fusion revealed by inhibitors that target N- and C-terminal helical regions of HIV-1 gp41 Biochemistry. 43: 8230-8233. PMID 15209519 DOI: 10.1021/Bi049957V |
0.308 |
|
| 2004 |
Bewley CA, Cai M, Ray S, Ghirlando R, Yamaguchi M, Muramoto K. New carbohydrate specificity and HIV-1 fusion blocking activity of the cyanobacterial protein MVL: NMR, ITC and sedimentation equilibrium studies. Journal of Molecular Biology. 339: 901-14. PMID 15165858 DOI: 10.1016/J.Jmb.2004.04.019 |
0.328 |
|
| 2003 |
Louis JM, Nesheiwat I, Chang L, Clore GM, Bewley CA. Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion. The Journal of Biological Chemistry. 278: 20278-85. PMID 12654905 DOI: 10.1074/Jbc.M301627200 |
0.375 |
|
| 2002 |
Bewley CA, Kiyonaka S, Hamachi I. Site-specific discrimination by cyanovirin-N for α-linked trisaccharides comprising the three arms of Man8 and Man9 Journal of Molecular Biology. 322: 881-889. PMID 12270721 DOI: 10.1016/S0022-2836(02)00842-2 |
0.319 |
|
| 2002 |
Chang LC, Bewley CA. Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: characterization of low affinity carbohydrate binding site knockout mutants. Journal of Molecular Biology. 318: 1-8. PMID 12054763 DOI: 10.1016/S0022-2836(02)00045-1 |
0.311 |
|
| 2002 |
Kelley BS, Chang LC, Bewley CA. Engineering an obligate domain-swapped dimer of cyanovirin-N with enhanced anti-HIV activity. Journal of the American Chemical Society. 124: 3210-1. PMID 11916396 DOI: 10.1021/Ja025537M |
0.337 |
|
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