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Jeffery W. Kelly, Ph.D. - Publications

Affiliations: 
Chemistry and Molecular Medicine Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Chemical Biology, protein folding
Website:
http://www.scripps.edu/skaggs/kelly/dr_kelly.php?a=l&cid=1
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353 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kline GM, Madrazo N, Cole CM, Pannikkat M, Bollong MJ, Rosarda JD, Kelly JW, Wiseman RL. Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis. Rsc Chemical Biology. 5: 866-876. PMID 39211477 DOI: 10.1039/d4cb00027g  0.491
2024 Touvier T, Veneri FA, Claessens A, Ferri C, Mastrangelo R, Sorgiati N, Bianchi F, Valenzano S, Del Carro U, Rivellini C, Duong P, Shy ME, Kelly JW, Svaren J, Wiseman RL, et al. Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B. Biorxiv : the Preprint Server For Biology. PMID 38352425 DOI: 10.1101/2024.01.31.577760  0.498
2023 Xie L, Bowman ME, Louie GV, Zhang C, Ardejani MS, Huang X, Chu Q, Donaldson CJ, Vaughan JM, Shan H, Powers ET, Kelly JW, Lyumkis D, Noel JP, Saghatelian A. Biochemistry and Protein Interactions of the CYREN Microprotein. Biochemistry. PMID 37813856 DOI: 10.1021/acs.biochem.3c00397  0.801
2023 Kline GM, Paxman RJ, Lin CY, Madrazo N, Yoon L, Grandjean JMD, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators. Acs Chemical Biology. PMID 37523656 DOI: 10.1021/acschembio.3c00042  0.689
2023 Perea V, Cole C, Lebeau J, Dolina V, Baron KR, Madhavan A, Kelly JW, Grotjahn DA, Wiseman RL. PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid. The Embo Journal. e113908. PMID 37306086 DOI: 10.15252/embj.2023113908  0.443
2023 Elsasser S, Elia LP, Morimoto RI, Powers ET, Elsasser S, Finley D, Costa B, Budron M, Tokuno Z, Wang S, Iyer RG, Barth B, Mockler E, Elia LP, Finkbeiner S, ... ... Kelly JW, et al. A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway. Biorxiv : the Preprint Server For Biology. PMID 36993380 DOI: 10.1101/2023.03.22.533675  0.576
2023 Kline GM, Paxman RJ, Lin CY, Madrazo N, Grandjean JM, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators. Biorxiv : the Preprint Server For Biology. PMID 36712115 DOI: 10.1101/2023.01.16.524237  0.676
2023 Tsai FJ, Jaeger M, Coelho T, Powers ET, Kelly JW. Tafamidis concentration required for transthyretin stabilisation in cerebrospinal fluid. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-11. PMID 36691999 DOI: 10.1080/13506129.2023.2167595  0.519
2022 Sun S, Wang C, Zhao P, Kline GM, Grandjean JMD, Jiang X, Labaudiniere R, Wiseman RL, Kelly JW, Balch WE. Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis. Cell Chemical Biology. PMID 36630963 DOI: 10.1016/j.chembiol.2022.12.004  0.51
2022 Tsai FJ, Nelson LT, Kline GM, Jäger M, Berk JL, Sekijima Y, Powers ET, Kelly JW. Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-5. PMID 36444793 DOI: 10.1080/13506129.2022.2148094  0.645
2022 Monteiro C, Mesgarzadeh JS, Anselmo J, Fernandes J, Novais M, Rodrigues C, Powers DL, Powers ET, Coelho T, Kelly JW. Tafamidis polyneuropathy amelioration requires modest increases in transthyretin stability even though increases in plasma native TTR and decreases in non-native TTR do not predict response. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-15. PMID 36178172 DOI: 10.1080/13506129.2022.2126308  0.569
2022 Mesgarzadeh JS, Romine IC, Smith-Cohen EM, Grandjean JMD, Kelly JW, Genereux JC, Wiseman RL. ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors. Cells. 11. PMID 35626697 DOI: 10.3390/cells11101661  0.575
2022 Wang M, Cotter E, Wang YJ, Fu X, Whittsette AL, Lynch JW, Wiseman RL, Kelly JW, Keramidas A, Mu TW. Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA receptors. Cell & Bioscience. 12: 48. PMID 35477478 DOI: 10.1186/s13578-022-00783-w  0.583
2022 Chiti F, Kelly JW. Small molecule protein binding to correct cellular folding or stabilize the native state against misfolding and aggregation. Current Opinion in Structural Biology. 72: 267-278. PMID 34999558 DOI: 10.1016/j.sbi.2021.11.009  0.309
2021 Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. Acs Chemical Biology. PMID 34797633 DOI: 10.1021/acschembio.1c00810  0.476
2021 Kroeger H, Grandjean JMD, Chiang WJ, Bindels DD, Mastey R, Okalova J, Nguyen A, Powers ET, Kelly JW, Grimsey NJ, Michaelides M, Carroll J, Wiseman RL, Lin JH. ATF6 is essential for human cone photoreceptor development. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34561305 DOI: 10.1073/pnas.2103196118  0.654
2021 Ardejani MS, Noodleman L, Powers ET, Kelly JW. Stereoelectronic effects in stabilizing protein-N-glycan interactions revealed by experiment and machine learning. Nature Chemistry. PMID 33723379 DOI: 10.1038/s41557-021-00646-w  0.787
2021 Rius B, Mesgarzadeh JS, Romine IC, Paxman RJ, Kelly JW, Wiseman RL. Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion. Blood Advances. 5: 1037-1049. PMID 33599742 DOI: 10.1182/bloodadvances.2020002813  0.515
2020 Kelly J, Powers E. Response. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-2. PMID 33274653 DOI: 10.1080/13506129.2020.1853094  0.475
2020 Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW. Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery. Nature Chemistry. PMID 32868886 DOI: 10.1038/S41557-020-0530-4  0.372
2020 Nelson LT, Paxman RJ, Xu J, Webb B, Powers ET, Kelly JW. Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-6. PMID 32811187 DOI: 10.1080/13506129.2020.1808783  0.586
2020 Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nature Chemical Biology. PMID 32690944 DOI: 10.1038/S41589-020-0584-Z  0.796
2020 Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins. Bioorganic & Medicinal Chemistry Letters. 30: 127356. PMID 32631553 DOI: 10.1016/J.Bmcl.2020.127356  0.355
2020 Dasari AKR, Arreola J, Michael B, Griffin RG, Kelly JW, Lim KH. Disruption of the CD loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway. Biochemistry. PMID 32500705 DOI: 10.1021/Acs.Biochem.0C00079  0.403
2020 Dasari AKR, Hung I, Michael B, Gan Z, Kelly JW, Connors LH, Griffin RG, Lim KH. Structural Characterization of Cardiac ex vivo Transthyretin Amyloid: Insight into Transthyretin Misfolding Pathway in vivo. Biochemistry. PMID 32338497 DOI: 10.1021/Acs.Biochem.0C00091  0.414
2020 Sinha A, Chang JC, Xu P, Gindinova K, Cho Y, Sun W, Wu X, Li YM, Greengard P, Kelly JW, Sinha SC. Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage Acs Medicinal Chemistry Letters. 11: 1973-1979. DOI: 10.1021/Acsmedchemlett.9B00688  0.306
2019 Rennella E, Morgan GJ, Yan N, Kelly JW, Kay LE. The role of protein thermodynamics and primary structure in fibrillogenesis of variable domains from immunoglobulin light-chains. Journal of the American Chemical Society. PMID 31364359 DOI: 10.1021/Jacs.9B05499  0.386
2019 Monteiro C, Mesgazardeh JS, Anselmo J, Fernandes J, Novais M, Rodrigues C, Brighty GJ, Powers DL, Powers ET, Coelho T, Kelly JW. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy. Jci Insight. 4. PMID 31217346 DOI: 10.1172/Jci.Insight.126526  0.571
2019 Ruberg FL, Grogan M, Hanna M, Kelly JW, Maurer MS. Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 73: 2872-2891. PMID 31171094 DOI: 10.1016/J.Jacc.2019.04.003  0.314
2019 Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. Cell Chemical Biology. PMID 31105062 DOI: 10.1016/J.Chembiol.2019.04.001  0.805
2019 Kelly JW. Pharmacologic Approaches for Adapting Proteostasis in the Secretory Pathway to Ameliorate Protein Conformational Diseases. Cold Spring Harbor Perspectives in Biology. PMID 31088828 DOI: 10.1101/Cshperspect.A034108  0.372
2019 Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, ... Kelly JW, et al. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30971495 DOI: 10.1073/Pnas.1817567116  0.356
2019 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. 10: 187. PMID 30643122 DOI: 10.1016/J.Yjmcc.2018.07.047  0.763
2018 Rennella E, Morgan GJ, Kelly JW, Kay LE. Role of domain interactions in the aggregation of full-length immunoglobulin light chains. Proceedings of the National Academy of Sciences of the United States of America. PMID 30598439 DOI: 10.1073/Pnas.1817538116  0.352
2018 Sun X, Jaeger M, Kelly JW, Dyson J, Wright PE. Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin. Biochemistry. PMID 30540442 DOI: 10.1021/Acs.Biochem.8B01046  0.301
2018 Lampkin BJ, Monteiro C, Powers ET, Bouc PM, Kelly JW, VanVeller B. A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence. Organic & Biomolecular Chemistry. PMID 30534794 DOI: 10.1039/C8Ob02673D  0.588
2018 Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Elife. 7. PMID 30084354 DOI: 10.7554/Elife.37168  0.804
2018 Madhivanan K, Greiner ER, Alves-Ferreira M, Soriano-Castell D, Rouzbeh N, Aguirre CA, Paulsson JF, Chapman J, Jiang X, Ooi FK, Lemos C, Dillin A, Prahlad V, Kelly JW, Encalada SE. Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in . Proceedings of the National Academy of Sciences of the United States of America. PMID 30061394 DOI: 10.1073/Pnas.1801117115  0.334
2018 Kelly JW. The two shapes of the Tau protein. Elife. 7. PMID 29988017 DOI: 10.7554/Elife.38516  0.326
2018 Leach BI, Zhang X, Kelly JW, Dyson J, Wright PE. NMR measurements reveal the structural basis of transthyretin destabilization by pathogenic mutations. Biochemistry. PMID 29972637 DOI: 10.1021/Acs.Biochem.8B00642  0.373
2018 Bamberger C, Martínez-Bartolomé S, Montgomery M, Pankow S, Hulleman JD, Kelly JW, Yates JR. Deducing the presence of proteins and proteoforms in quantitative proteomics. Nature Communications. 9: 2320. PMID 29899466 DOI: 10.1038/S41467-018-04411-5  0.675
2018 Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Science Signaling. 11. PMID 29440509 DOI: 10.1126/Scisignal.Aan5785  0.787
2018 Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Author response: Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins Elife. DOI: 10.7554/Elife.37168.022  0.759
2018 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Abstract 547: Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.547  0.762
2018 Blackwood E, Azizi K, Thuerauf D, Paxman R, Plate L, Kelly J, Wiseman R, Glembotski C. Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis Journal of Molecular and Cellular Cardiology. 124: 97. DOI: 10.1016/j.yjmcc.2018.07.047  0.749
2018 Eisele YS, Janssen ME, Ma D, Nguyen B, Plate L, Morgan GJ, Reixach N, Buxbaum JN, Wiseman RL, Lander GC, Kelly JW. P3-146: Formation And Toxicity Of Transthyretin (Ttr) Oligomers In Vitro And In Patients With Familial Amyloid Polyneuropathy Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1503  0.687
2017 Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society. PMID 29265822 DOI: 10.1021/Jacs.7B08366  0.791
2017 Morgan GJ, Usher GA, Kelly JW. Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients? Biochemistry. PMID 29200282 DOI: 10.1021/Acs.Biochem.7B00579  0.437
2017 Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, et al. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Reports. 21: 2614-2627. PMID 29186695 DOI: 10.1016/J.Celrep.2017.11.009  0.367
2017 Morgan GJ, Burkhardt DH, Kelly JW, Powers ET. Translation efficiency is maintained at elevated temperature in E. coli. The Journal of Biological Chemistry. PMID 29183994 DOI: 10.1074/Jbc.Ra117.000284  0.567
2017 Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, ... ... Kelly JW, et al. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Science Translational Medicine. 9. PMID 28904227 DOI: 10.1126/Scitranslmed.Aam7621  0.784
2017 Lim KH, Dasari AKR, Ma R, Hung I, Gan Z, Kelly JW, Fitzgerald MC. Pathogenic Mutations Induce Partial Structural Changes in Native β-Sheet Structure of Transthyretin and Accelerate Aggregation. Biochemistry. PMID 28820582 DOI: 10.1021/Acs.Biochem.7B00658  0.377
2017 Ardejani MS, Powers ET, Kelly JW. Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities. Accounts of Chemical Research. PMID 28723063 DOI: 10.1021/Acs.Accounts.7B00195  0.795
2017 Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. The Embo Journal. PMID 28655754 DOI: 10.15252/Embj.201695616  0.804
2017 Connelly S, Mortenson DE, Choi S, Wilson IA, Powers ET, Kelly JW, Johnson SM. Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28625364 DOI: 10.1016/J.Bmcl.2017.05.080  0.747
2017 Fernandes L, Moraes N, Sagrillo FS, Magalhães AV, de Moraes MC, Romão L, Kelly JW, Foguel D, Grimster NP, Palhano FL. An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils. Acs Chemical Neuroscience. PMID 28425704 DOI: 10.1021/Acschemneuro.7B00017  0.732
2017 Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK. REDD1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28334504 DOI: 10.1002/Art.40104  0.559
2016 Chen JJ, Genereux JC, Suh EH, Vartabedian VF, Rius B, Qu S, Dendle MT, Kelly JW, Wiseman RL. Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells. Cell Chemical Biology. PMID 27720586 DOI: 10.1016/J.Chembiol.2016.09.001  0.757
2016 Lim KH, Dasari AK, Hung IF, Gan Z, Kelly JW, Wright PE, Wemmer DE. Solid-State NMR Studies Reveal Native-like β-sheet Structures in Transthyretin amyloid. Biochemistry. PMID 27589034 DOI: 10.1021/Acs.Biochem.6B00649  0.332
2016 Kurian SM, Novais M, Whisenant T, Gelbart T, Buxbaum JN, Kelly JW, Coelho T, Salomon DR. Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures. Theranostics. 6: 1792-809. PMID 27570551 DOI: 10.7150/Thno.14584  0.319
2016 Morgan GJ, Kelly JW. The kinetic stability of a full-length antibody light chain dimer determines whether endoproteolysis can release amyloidogenic variable domains. Journal of Molecular Biology. PMID 27569045 DOI: 10.1016/J.Jmb.2016.08.021  0.345
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, ... ... Kelly JW, et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 5. PMID 27435961 DOI: 10.7554/Elife.15550  0.814
2016 Plate L, Paxman RJ, Wiseman RL, Kelly JW. Modulating protein quality control. Elife. 5. PMID 27435959 DOI: 10.7554/Elife.18431  0.784
2016 Hsu CH, Park S, Mortenson DE, Foley BL, Wang X, Woods RJ, Case DA, Powers ET, Wong CH, Dyson HJ, Kelly JW. The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate. Journal of the American Chemical Society. PMID 27249581 DOI: 10.1021/Jacs.6B02879  0.585
2016 Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, ... Kelly JW, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/Jacs.6B02960  0.788
2016 Ankarcrona M, Winblad B, Monteiro C, Fearns C, Powers ET, Johansson J, Westermark GT, Presto J, Ericzon BG, Kelly JW. Current and future treatment of amyloid diseases. Journal of Internal Medicine. PMID 27165517 DOI: 10.1111/Joim.12506  0.651
2016 Chen W, Kong L, Connelly S, Dendle JM, Liu Y, Wilson IA, Powers ET, Kelly JW. Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chemical Biology. PMID 27128252 DOI: 10.1021/Acschembio.5B01035  0.708
2016 Lim KH, Dasari AK, Hung I, Gan Z, Kelly JW, Wemmer DE. Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR. Biochemistry. PMID 26998642 DOI: 10.1021/Acs.Biochem.6B00164  0.339
2016 Coelho T, Merlini G, Bulawa CE, Fleming JA, Judge DP, Kelly JW, Maurer MS, Planté-Bordeneuve V, Labaudinière R, Mundayat R, Riley S, Lombardo I, Huertas P. Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis. Neurology and Therapy. PMID 26894299 DOI: 10.1007/S40120-016-0040-X  0.406
2016 Dave K, Jäger M, Nguyen H, Kelly JW, Gruebele M. High-resolution mapping of the folding transition state of a WW domain. Journal of Molecular Biology. PMID 26880334 DOI: 10.1016/J.Jmb.2016.02.008  0.342
2016 Baranczak A, Kelly JW. A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases. Current Opinion in Chemical Biology. 32: 10-21. PMID 26859714 DOI: 10.1016/J.Cbpa.2016.01.009  0.393
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, ... ... Kelly JW, et al. Author response: Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife. DOI: 10.7554/Elife.15550.026  0.783
2016 Hsu C, Park S, Mortenson DE, Foley B, Wang X, Woods RJ, Case DA, Powers ET, Wong C, Dyson H, Kelly JW. Solution Structure of N-Galactosylated Pin1 WW Domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Nc3/Pdb  0.551
2015 Chen W, Dong J, Li S, Liu Y, Wang Y, Yoon L, Wu P, Sharpless KB, Kelly JW. Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy. Angewandte Chemie (International Ed. in English). PMID 26696445 DOI: 10.1002/Anie.201509016  0.555
2015 Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. Targeting protein aggregation for the treatment of degenerative diseases. Nature Reviews. Drug Discovery. PMID 26338154 DOI: 10.1038/Nrd4593  0.804
2015 Liu Y, Zhang X, Chen W, Tan YL, Kelly JW. Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells. Journal of the American Chemical Society. PMID 26305239 DOI: 10.1021/Jacs.5B04366  0.595
2015 Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity. Chemistry & Biology. 22: 1052-62. PMID 26190824 DOI: 10.1016/J.Chembiol.2015.06.017  0.785
2015 Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW. A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. Journal of the American Chemical Society. 137: 7404-14. PMID 26051248 DOI: 10.1021/Jacs.5B03042  0.683
2015 Cho Y, Zhang X, Pobre KF, Liu Y, Powers DL, Kelly JW, Gierasch LM, Powers ET. Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli. Cell Reports. 11: 321-33. PMID 25843722 DOI: 10.1016/J.Celrep.2015.03.018  0.632
2015 Hulleman JD, Kelly JW. Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 565-75. PMID 25389134 DOI: 10.1096/Fj.14-255414  0.664
2015 Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. The Embo Journal. 34: 4-19. PMID 25361606 DOI: 10.15252/Embj.201488896  0.813
2015 Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto SI, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Kelly JW, et al. Correction to supporting information for "Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss," Proceedings of the National Academy of Sciences of the United States of America. 112: E3751-E3752. DOI: 10.1073/pnas.1511282112  0.483
2015 Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.06.017  0.769
2014 Hebert DN, Lamriben L, Powers ET, Kelly JW. The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis. Nature Chemical Biology. 10: 902-10. PMID 25325701 DOI: 10.1038/Nchembio.1651  0.64
2014 Liu Y, Zhang X, Tan YL, Bhabha G, Ekiert DC, Kipnis Y, Bjelic S, Baker D, Kelly JW. De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. Journal of the American Chemical Society. 136: 13102-5. PMID 25209927 DOI: 10.1021/Ja5056356  0.33
2014 Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Proceedings of the National Academy of Sciences of the United States of America. 111: 13046-51. PMID 25157167 DOI: 10.1073/Pnas.1406050111  0.797
2014 Greiner ER, Kelly JW, Palhano FL. Immunoprecipitation of amyloid fibrils by the use of an antibody that recognizes a generic epitope common to amyloid fibrils. Plos One. 9: e105433. PMID 25144803 DOI: 10.1371/Journal.Pone.0105433  0.71
2014 Tan YL, Genereux JC, Pankow S, Aerts JM, Yates JR, Kelly JW. ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease. Chemistry & Biology. 21: 967-76. PMID 25126989 DOI: 10.1016/J.Chembiol.2014.06.008  0.38
2014 Zhang X, Liu Y, Genereux JC, Nolan C, Singh M, Kelly JW. Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli. Acs Chemical Biology. 9: 1945-9. PMID 25051296 DOI: 10.1021/Cb5004477  0.376
2014 Zhang X, Kelly JW. Chaperonins resculpt folding free energy landscapes to avoid kinetic traps and accelerate protein folding. Journal of Molecular Biology. 426: 2736-8. PMID 24909364 DOI: 10.1016/J.Jmb.2014.06.001  0.378
2014 Rappley I, Monteiro C, Novais M, Baranczak A, Solis G, Wiseman RL, Helmke S, Maurer MS, Coelho T, Powers ET, Kelly JW. Quantification of transthyretin kinetic stability in human plasma using subunit exchange. Biochemistry. 53: 1993-2006. PMID 24661308 DOI: 10.1021/Bi500171J  0.78
2014 Liu Y, Tan YL, Zhang X, Bhabha G, Ekiert DC, Genereux JC, Cho Y, Kipnis Y, Bjelic S, Baker D, Kelly JW. Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proceedings of the National Academy of Sciences of the United States of America. 111: 4449-54. PMID 24591605 DOI: 10.1073/Pnas.1323268111  0.434
2014 Baranczak A, Connelly S, Liu Y, Choi S, Grimster NP, Powers ET, Wilson IA, Kelly JW. Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn. Biopolymers. 101: 484-95. PMID 24105107 DOI: 10.1002/Bip.22407  0.662
2013 Berk JL, Suhr OB, Obici L, Sekijima Y, Zeldenrust SR, Yamashita T, Heneghan MA, Gorevic PD, Litchy WJ, Wiesman JF, Nordh E, Corato M, Lozza A, Cortese A, Robinson-Papp J, ... ... Kelly JW, et al. Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial. Jama. 310: 2658-67. PMID 24368466 DOI: 10.1001/Jama.2013.283815  0.507
2013 Li X, Zhang X, Ladiwala AR, Du D, Yadav JK, Tessier PM, Wright PE, Kelly JW, Buxbaum JN. Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19423-33. PMID 24336709 DOI: 10.1523/Jneurosci.2561-13.2013  0.607
2013 Suh EH, Liu Y, Connelly S, Genereux JC, Wilson IA, Kelly JW. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. Journal of the American Chemical Society. 135: 17869-80. PMID 24180271 DOI: 10.1021/Ja408230K  0.361
2013 Myung N, Connelly S, Kim B, Park SJ, Wilson IA, Kelly JW, Choi S. Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chemical Communications (Cambridge, England). 49: 9188-90. PMID 23989101 DOI: 10.1039/C3Cc44667K  0.454
2013 Murray AN, Palhano FL, Bieschke J, Kelly JW. Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes. Protein Science : a Publication of the Protein Society. 22: 1531-41. PMID 23963844 DOI: 10.1002/Pro.2339  0.793
2013 Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Kelly JW, et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America. 110: E2518-27. PMID 23776240 DOI: 10.1073/Pnas.1306832110  0.566
2013 Chen W, Enck S, Price JL, Powers DL, Powers ET, Wong CH, Dyson HJ, Kelly JW. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins. Journal of the American Chemical Society. 135: 9877-84. PMID 23742246 DOI: 10.1021/Ja4040472  0.753
2013 Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7. PMID 23716704 DOI: 10.1073/Pnas.1300761110  0.631
2013 Shoulders MD, Ryno LM, Cooley CB, Kelly JW, Wiseman RL. Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells. Journal of the American Chemical Society. 135: 8129-32. PMID 23682758 DOI: 10.1021/Ja402756P  0.768
2013 Ryno LM, Wiseman RL, Kelly JW. Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases. Current Opinion in Chemical Biology. 17: 346-52. PMID 23647985 DOI: 10.1016/J.Cbpa.2013.04.009  0.808
2013 Palhano FL, Lee J, Grimster NP, Kelly JW. Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils. Journal of the American Chemical Society. 135: 7503-10. PMID 23611538 DOI: 10.1021/Ja3115696  0.759
2013 Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR, Su AI, Kelly JW, Wiseman RL. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Reports. 3: 1279-92. PMID 23583182 DOI: 10.1016/J.Celrep.2013.03.024  0.792
2013 Ong DS, Wang YJ, Tan YL, Yates JR, Mu TW, Kelly JW. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts. Chemistry & Biology. 20: 403-15. PMID 23434032 DOI: 10.1016/J.Chembiol.2012.11.014  0.595
2013 Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. Journal of the American Chemical Society. 135: 5656-68. PMID 23350654 DOI: 10.1021/Ja311729D  0.621
2013 Lim KH, Dyson HJ, Kelly JW, Wright PE. Localized structural fluctuations promote amyloidogenic conformations in transthyretin. Journal of Molecular Biology. 425: 977-88. PMID 23318953 DOI: 10.1016/J.Jmb.2013.01.008  0.382
2013 Hulleman JD, Brown SJ, Rosen H, Kelly JW. A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion. Journal of Biomolecular Screening. 18: 647-58. PMID 23230284 DOI: 10.1177/1087057112469405  0.675
2013 Enck S, Chen W, Price J, Powers E, Wong C, Dyson H, Kelly J. NMR solution structure of Pin1 WW domain mutant 5-1g Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2M9E/Pdb  0.739
2013 Fearns C, Connelly S, Powers ET, Kelly JW. Development of Therapeutic Strategies for the Transthyretin Amyloidoses Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties. 373-394. DOI: 10.1002/9783527654185.ch17  0.495
2012 Fowler DM, Kelly JW. Functional amyloidogenesis and cytotoxicity-insights into biology and pathology. Plos Biology. 10: e1001459. PMID 23300381 DOI: 10.1371/Journal.Pbio.1001459  0.65
2012 Murray AN, Kelly JW. Hsp104 gives clients the individual attention they need. Cell. 151: 695-7. PMID 23141530 DOI: 10.1016/J.Cell.2012.10.033  0.348
2012 Araya CL, Fowler DM, Chen W, Muniez I, Kelly JW, Fields S. A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function. Proceedings of the National Academy of Sciences of the United States of America. 109: 16858-63. PMID 23035249 DOI: 10.1073/Pnas.1209751109  0.737
2012 Azevedo EP, Guimarães-Costa AB, Torezani GS, Braga CA, Palhano FL, Kelly JW, Saraiva EM, Foguel D. Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase. The Journal of Biological Chemistry. 287: 37206-18. PMID 22918834 DOI: 10.1074/Jbc.M112.369942  0.71
2012 Hulleman JD, Balch WE, Kelly JW. Translational attenuation differentially alters the fate of disease-associated fibulin proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4548-60. PMID 22872678 DOI: 10.1096/Fj.11-202861  0.704
2012 Price JL, Culyba EK, Chen W, Murray AN, Hanson SR, Wong CH, Powers ET, Kelly JW. N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability. Biopolymers. 98: 195-211. PMID 22782562 DOI: 10.1002/Bip.22030  0.788
2012 Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proceedings of the National Academy of Sciences of the United States of America. 109: 9629-34. PMID 22645360 DOI: 10.1073/Pnas.1121005109  0.81
2012 Berk JL, Suhr OB, Sekijima Y, Yamashita T, Heneghan M, Zeldenrust SR, Ando Y, Ikeda S, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Dyck PJ, Obici L, et al. The Diflunisal Trial: study accrual and drug tolerance. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 19: 37-8. PMID 22551208 DOI: 10.3109/13506129.2012.678509  0.484
2012 Price JL, Shental-Bechor D, Dhar A, Turner MJ, Powers ET, Gruebele M, Levy Y, Kelly JW. Correction to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics. Journal of the American Chemical Society. 134: 4450-4451. PMID 22500055 DOI: 10.1021/Ja300899D  0.697
2012 Solomon JP, Page LJ, Balch WE, Kelly JW. Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention. Critical Reviews in Biochemistry and Molecular Biology. 47: 282-96. PMID 22360545 DOI: 10.3109/10409238.2012.661401  0.415
2012 Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW. The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug. Journal of Molecular Biology. 421: 185-203. PMID 22244854 DOI: 10.1016/J.Jmb.2011.12.060  0.71
2012 Fowler DM, Koulov AV, Kelly JW, Balch WE. Mammalian functional amyloid The Functional Fold: Amyloid Structures in Nature. 147-158. DOI: 10.4032/9789814267625  0.579
2011 Azevedo EP, Pereira HM, Garratt RC, Kelly JW, Foguel D, Palhano FL. Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid. Biochemistry. 50: 11070-83. PMID 22091638 DOI: 10.1021/Bi201365R  0.736
2011 Orwig SD, Tan YL, Grimster NP, Yu Z, Powers ET, Kelly JW, Lieberman RL. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease. Biochemistry. 50: 10647-57. PMID 22047104 DOI: 10.1021/Bi201619Z  0.647
2011 Hulleman JD, Kaushal S, Balch WE, Kelly JW. Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration. Molecular Biology of the Cell. 22: 4765-75. PMID 22031286 DOI: 10.1091/Mbc.E11-08-0695  0.682
2011 Price JL, Powers ET, Kelly JW. N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation. Acs Chemical Biology. 6: 1188-92. PMID 21939258 DOI: 10.1021/Cb200277U  0.718
2011 Lindquist SL, Kelly JW. Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis. Cold Spring Harbor Perspectives in Biology. 3. PMID 21900404 DOI: 10.1101/Cshperspect.A004507  0.425
2011 Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Science Translational Medicine. 3: 97ra81. PMID 21865539 DOI: 10.1126/Scitranslmed.3002473  0.649
2011 Berk JL, Dyck PJ, Obici L, Zeldenrust SR, Sekijima Y, Yamashita T, Ando Y, Ikeda SI, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Suhr OB. The diflunisal trial: update on study drug tolerance and disease progression. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 18: 196-7. PMID 21838485 DOI: 10.3109/13506129.2011.574354073  0.407
2011 Price JL, Powers DL, Powers ET, Kelly JW. Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts. Proceedings of the National Academy of Sciences of the United States of America. 108: 14127-32. PMID 21825145 DOI: 10.1073/Pnas.1105880108  0.731
2011 Lee J, Culyba EK, Powers ET, Kelly JW. Amyloid-β forms fibrils by nucleated conformational conversion of oligomers. Nature Chemical Biology. 7: 602-9. PMID 21804535 DOI: 10.1038/Nchembio.624  0.701
2011 Reinhart PH, Kelly JW. Treating the periphery to ameliorate neurodegenerative diseases. Cell. 145: 813-4. PMID 21663784 DOI: 10.1016/J.Cell.2011.05.031  0.3
2011 Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochemical and Biophysical Research Communications. 410: 707-13. PMID 21557933 DOI: 10.1016/J.Bbrc.2011.04.133  0.797
2011 Wiseman RL, Kelly JW. Cell biology. Phosphatase inhibition delays translational recovery. Science (New York, N.Y.). 332: 44-5. PMID 21454777 DOI: 10.1126/Science.1204505  0.714
2011 Solomon JP, Bourgault S, Powers ET, Kelly JW. Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension. Biochemistry. 50: 2486-98. PMID 21348501 DOI: 10.1021/Bi101905N  0.794
2011 Culyba EK, Price JL, Hanson SR, Dhar A, Wong CH, Gruebele M, Powers ET, Kelly JW. Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns. Science (New York, N.Y.). 331: 571-5. PMID 21292975 DOI: 10.1126/Science.1198461  0.73
2011 Choi S, Kelly JW. A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin. Bioorganic & Medicinal Chemistry. 19: 1505-14. PMID 21273081 DOI: 10.1016/J.Bmc.2010.12.050  0.492
2011 Du D, Murray AN, Cohen E, Kim HE, Simkovsky R, Dillin A, Kelly JW. A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues. Biochemistry. 50: 1607-17. PMID 21268584 DOI: 10.1021/Bi1013744  0.57
2011 Bourgault S, Solomon JP, Reixach N, Kelly JW. Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion. Biochemistry. 50: 1001-15. PMID 21194234 DOI: 10.1021/Bi101822Y  0.731
2011 Ong DS, Kelly JW. Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseases. Current Opinion in Cell Biology. 23: 231-8. PMID 21146391 DOI: 10.1016/J.Ceb.2010.11.002  0.404
2011 Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Erratum to “Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs” [Biochem. Biophys. Res. Commun. 410 (2011) 707–713] Biochemical and Biophysical Research Communications. 412: 196. DOI: 10.1016/J.Bbrc.2011.07.093  0.786
2010 Choi S, Ong DS, Kelly JW. A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate. Journal of the American Chemical Society. 132: 16043-51. PMID 20964336 DOI: 10.1021/Ja104999V  0.463
2010 Price JL, Shental-Bechor D, Dhar A, Turner MJ, Powers ET, Gruebele M, Levy Y, Kelly JW. Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics. Journal of the American Chemical Society. 132: 15359-67. PMID 20936810 DOI: 10.1021/Ja106896T  0.737
2010 Ong DS, Mu TW, Palmer AE, Kelly JW. Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis. Nature Chemical Biology. 6: 424-32. PMID 20453863 DOI: 10.1038/Nchembio.368  0.536
2010 Trivella DB, Bleicher L, Palmieri Lde C, Wiggers HJ, Montanari CA, Kelly JW, Lima LM, Foguel D, Polikarpov I. Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. Journal of Structural Biology. 170: 522-31. PMID 20211733 DOI: 10.1016/J.Jsb.2010.03.002  0.372
2010 Murray AN, Solomon JP, Wang YJ, Balch WE, Kelly JW. Discovery and characterization of a mammalian amyloid disaggregation activity. Protein Science : a Publication of the Protein Society. 19: 836-46. PMID 20162625 DOI: 10.1002/Pro.363  0.403
2010 Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA. Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. Current Opinion in Structural Biology. 20: 54-62. PMID 20133122 DOI: 10.1016/J.Sbi.2009.12.009  0.649
2010 Choi S, Connelly S, Reixach N, Wilson IA, Kelly JW. Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nature Chemical Biology. 6: 133-9. PMID 20081815 DOI: 10.1038/Nchembio.281  0.53
2010 Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. Journal of the American Chemical Society. 132: 1359-70. PMID 20043671 DOI: 10.1021/Ja908562Q  0.655
2010 Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, Dillin A. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell. 9: 126-34. PMID 20003171 DOI: 10.1111/J.1474-9726.2009.00541.X  0.548
2010 Naik S, Haque I, Degner N, Kornilayev B, Bomhoff G, Hodges J, Khorassani AA, Katayama H, Morris J, Kelly J, Seed J, Fisher MT. Identifying protein stabilizing ligands using GroEL. Biopolymers. 93: 237-51. PMID 19802819 DOI: 10.1002/Bip.21319  0.351
2010 Johnson SM, Wiseman L, Paulsson JF, Choi S, Powers ET, Buxbaum JN, Kelly JW. Understanding and Ameliorating the TTR Amyloidoses Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 967-1003. DOI: 10.1002/9780470572702.ch45  0.659
2009 Wiseman RL, Kelly JW. Evolving protein stability through genetic selection. Molecular Cell. 36: 730-1. PMID 20005835 DOI: 10.1016/J.Molcel.2009.11.023  0.716
2009 Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell. 139: 1157-69. PMID 20005808 DOI: 10.1016/J.Cell.2009.11.014  0.534
2009 Solomon JP, Yonemoto IT, Murray AN, Price JL, Powers ET, Balch WE, Kelly JW. The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic. Biochemistry. 48: 11370-80. PMID 19904968 DOI: 10.1021/Bi901368E  0.733
2009 Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 18563-8. PMID 19841277 DOI: 10.1073/Pnas.0804758106  0.81
2009 Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. The Journal of Biological Chemistry. 284: 35543-55. PMID 19840945 DOI: 10.1074/Jbc.M109.047449  0.66
2009 Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Science : a Publication of the Protein Society. 18: 2231-41. PMID 19701939 DOI: 10.1002/Pro.234  0.692
2009 Jäger M, Dendle M, Kelly JW. Sequence determinants of thermodynamic stability in a WW domain--an all-beta-sheet protein. Protein Science : a Publication of the Protein Society. 18: 1806-13. PMID 19565466 DOI: 10.1002/Pro.172  0.386
2009 Page LJ, Suk JY, Bazhenova L, Fleming SM, Wood M, Jiang Y, Guo LT, Mizisin AP, Kisilevsky R, Shelton GD, Balch WE, Kelly JW. Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 11125-30. PMID 19549824 DOI: 10.1073/Pnas.0811753106  0.579
2009 Fuller AA, Du D, Liu F, Davoren JE, Bhabha G, Kroon G, Case DA, Dyson HJ, Powers ET, Wipf P, Gruebele M, Kelly JW. Evaluating beta-turn mimics as beta-sheet folding nucleators. Proceedings of the National Academy of Sciences of the United States of America. 106: 11067-72. PMID 19541614 DOI: 10.1073/Pnas.0813012106  0.763
2009 Gao J, Bosco DA, Powers ET, Kelly JW. Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins. Nature Structural & Molecular Biology. 16: 684-90. PMID 19525973 DOI: 10.1038/Nsmb.1610  0.777
2009 Bunagan MR, Gao J, Kelly JW, Gai F. Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis. Journal of the American Chemical Society. 131: 7470-6. PMID 19425552 DOI: 10.1021/Ja901860F  0.594
2009 Fowler DM, Kelly JW. Aggregating knowledge about prions and amyloid. Cell. 137: 20-2. PMID 19345180 DOI: 10.1016/J.Cell.2009.03.030  0.65
2009 Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and chemical approaches to diseases of proteostasis deficiency. Annual Review of Biochemistry. 78: 959-91. PMID 19298183 DOI: 10.1146/Annurev.Biochem.052308.114844  0.654
2009 Hanson SR, Culyba EK, Hsu TL, Wong CH, Kelly JW, Powers ET. The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability. Proceedings of the National Academy of Sciences of the United States of America. 106: 3131-6. PMID 19204290 DOI: 10.1073/Pnas.0810318105  0.624
2009 Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. Journal of Medicinal Chemistry. 52: 1115-25. PMID 19191553 DOI: 10.1021/jm801347s  0.449
2008 Sekijima Y, Kelly JW, Ikeda S. Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses. Current Pharmaceutical Design. 14: 3219-30. PMID 19075702 DOI: 10.2174/138161208786404155  0.564
2008 Jager M, Deechongkit S, Koepf EK, Nguyen H, Gao J, Powers ET, Gruebele M, Kelly JW. Understanding the mechanism of beta-sheet folding from a chemical and biological perspective. Biopolymers. 90: 751-8. PMID 18844292 DOI: 10.1002/Bip.21101  0.802
2008 Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. Journal of Medicinal Chemistry. 51: 6348-58. PMID 18811132 DOI: 10.1021/Jm800435S  0.495
2008 Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR, Segatori L, Kelly JW. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell. 134: 769-81. PMID 18775310 DOI: 10.1016/J.Cell.2008.06.037  0.769
2008 Yonemoto IT, Kroon GJ, Dyson HJ, Balch WE, Kelly JW. Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry. 47: 9900-10. PMID 18710262 DOI: 10.1021/Bi800828U  0.357
2008 Palaninathan SK, Mohamedmohaideen NN, Snee WC, Kelly JW, Sacchettini JC. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. Journal of Molecular Biology. 382: 1157-67. PMID 18662699 DOI: 10.1016/J.Jmb.2008.07.029  0.308
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2008 Gao J, Kelly JW. Toward quantification of protein backbone-backbone hydrogen bonding energies: An energetic analysis of an amide-to-ester mutation in an alpha-helix within a protein. Protein Science : a Publication of the Protein Society. 17: 1096-101. PMID 18434500 DOI: 10.1110/Ps.083439708  0.568
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2008 Liu F, Du D, Fuller AA, Davoren JE, Wipf P, Kelly JW, Gruebele M. An experimental survey of the transition between two-state and downhill protein folding scenarios. Proceedings of the National Academy of Sciences of the United States of America. 105: 2369-74. PMID 18268349 DOI: 10.1073/Pnas.0711908105  0.695
2008 Mu TW, Fowler DM, Kelly JW. Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. Plos Biology. 6: e26. PMID 18254660 DOI: 10.1371/Journal.Pbio.0060026  0.719
2008 Johnson SM, Connelly S, Wilson IA, Kelly JW. Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. Journal of Medicinal Chemistry. 51: 260-70. PMID 18095641 DOI: 10.1021/Jm0708735  0.483
2008 Bieschke J, Siegel SJ, Fu Y, Kelly JW. Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Biochemistry. 47: 50-9. PMID 18078350 DOI: 10.1021/Bi701757V  0.784
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2007 Wiseman RL, Powers ET, Buxbaum JN, Kelly JW, Balch WE. An adaptable standard for protein export from the endoplasmic reticulum. Cell. 131: 809-21. PMID 18022373 DOI: 10.1016/J.Cell.2007.10.025  0.788
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2007 Jäger M, Dendle M, Fuller AA, Kelly JW. A cross-strand Trp Trp pair stabilizes the hPin1 WW domain at the expense of function. Protein Science : a Publication of the Protein Society. 16: 2306-13. PMID 17766376 DOI: 10.1110/Ps.072904107  0.632
2007 Wiseman RL, Koulov A, Powers E, Kelly JW, Balch WE. Protein energetics in maturation of the early secretory pathway. Current Opinion in Cell Biology. 19: 359-67. PMID 17686625 DOI: 10.1016/J.Ceb.2007.05.005  0.785
2007 Dillin A, Kelly JW. Medicine. The yin-yang of sirtuins. Science (New York, N.Y.). 317: 461-2. PMID 17656709 DOI: 10.1126/Science.1146585  0.329
2007 Jäger M, Nguyen H, Dendle M, Gruebele M, Kelly JW. Influence of hPin1 WW N-terminal domain boundaries on function, protein stability, and folding. Protein Science : a Publication of the Protein Society. 16: 1495-501. PMID 17586778 DOI: 10.1110/Ps.072775507  0.334
2007 Stewart CR, Wilson LM, Zhang Q, Pham CL, Waddington LJ, Staples MK, Stapleton D, Kelly JW, Howlett GJ. Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation. Biochemistry. 46: 5552-61. PMID 17429947 DOI: 10.1021/Bi602554Z  0.625
2007 Fowler DM, Koulov AV, Balch WE, Kelly JW. Functional amyloid--from bacteria to humans. Trends in Biochemical Sciences. 32: 217-24. PMID 17412596 DOI: 10.1016/J.Tibs.2007.03.003  0.655
2007 Siegel SJ, Bieschke J, Powers ET, Kelly JW. The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. Biochemistry. 46: 1503-10. PMID 17279615 DOI: 10.1021/Bi061853S  0.8
2007 Yu Z, Sawkar AR, Whalen LJ, Wong CH, Kelly JW. Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention. Journal of Medicinal Chemistry. 50: 94-100. PMID 17201413 DOI: 10.1021/Jm060677I  0.8
2006 Fu Y, Gao J, Bieschke J, Dendle MA, Kelly JW. Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies. Journal of the American Chemical Society. 128: 15948-9. PMID 17165703 DOI: 10.1021/Ja065303T  0.719
2006 Sawkar AR, Schmitz M, Zimmer KP, Reczek D, Edmunds T, Balch WE, Kelly JW. Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants. Acs Chemical Biology. 1: 235-51. PMID 17163678 DOI: 10.1021/Cb600187Q  0.805
2006 Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Molecular Cell. 24: 759-70. PMID 17157258 DOI: 10.1016/J.Molcel.2006.10.027  0.559
2006 Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR, Balch WE. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell. 127: 803-15. PMID 17110338 DOI: 10.1016/J.Cell.2006.09.043  0.357
2006 Sekijima Y, Dendle MA, Kelly JW. Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 236-49. PMID 17107884 DOI: 10.1080/13506120600960882  0.57
2006 Tojo K, Sekijima Y, Kelly JW, Ikeda S. Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis. Neuroscience Research. 56: 441-9. PMID 17028027 DOI: 10.1016/J.Neures.2006.08.014  0.562
2006 Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P, Kelly JW. Small molecule oxidation products trigger disease-associated protein misfolding. Accounts of Chemical Research. 39: 611-9. PMID 16981677 DOI: 10.1021/Ar0500766  0.8
2006 Sekijima Y, Dendle MT, Wiseman RL, White JT, D'Haeze W, Kelly JW. R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 57-66. PMID 16911959 DOI: 10.1080/13506120600722449  0.831
2006 Reixach N, Adamski-Werner SL, Kelly JW, Koziol J, Buxbaum JN. Cell based screening of inhibitors of transthyretin aggregation. Biochemical and Biophysical Research Communications. 348: 889-97. PMID 16904635 DOI: 10.1016/J.Bbrc.2006.07.109  0.395
2006 Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science (New York, N.Y.). 313: 1604-10. PMID 16902091 DOI: 10.1126/Science.1124646  0.696
2006 Kelly JW. Structural biology: proteins downhill all the way. Nature. 442: 255-6. PMID 16855578 DOI: 10.1038/442255A  0.339
2006 Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel JP, Gruebele M, Kelly JW. Structure-function-folding relationship in a WW domain. Proceedings of the National Academy of Sciences of the United States of America. 103: 10648-53. PMID 16807295 DOI: 10.1073/Pnas.0600511103  0.702
2006 Cordeiro Y, Kraineva J, Suarez MC, Tempesta AG, Kelly JW, Silva JL, Winter R, Foguel D. Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin. Biophysical Journal. 91: 957-67. PMID 16698785 DOI: 10.1529/Biophysj.106.085928  0.347
2006 Kelly JW, Balch WE. The integration of cell and chemical biology in protein folding. Nature Chemical Biology. 2: 224-7. PMID 16619016 DOI: 10.1038/Nchembio0506-224  0.302
2006 Sawkar AR, D'Haeze W, Kelly JW. Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease. Cellular and Molecular Life Sciences : Cmls. 63: 1179-92. PMID 16568247 DOI: 10.1007/S00018-005-5437-0  0.798
2006 Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nature Chemical Biology. 2: 249-53. PMID 16565714 DOI: 10.1038/Nchembio782  0.781
2006 Suk JY, Zhang F, Balch WE, Linhardt RJ, Kelly JW. Heparin accelerates gelsolin amyloidogenesis. Biochemistry. 45: 2234-42. PMID 16475811 DOI: 10.1021/Bi0519295  0.412
2006 Deechongkit S, Nguyen H, Jager M, Powers ET, Gruebele M, Kelly JW. Beta-sheet folding mechanisms from perturbation energetics. Current Opinion in Structural Biology. 16: 94-101. PMID 16442278 DOI: 10.1016/J.Sbi.2006.01.014  0.799
2006 Sörgjerd K, Ghafouri B, Jonsson BH, Kelly JW, Blond SY, Hammarström P. Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis. Journal of Molecular Biology. 356: 469-82. PMID 16376939 DOI: 10.1016/J.Jmb.2005.11.051  0.676
2006 Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, Kelly JW. Functional amyloid formation within mammalian tissue. Plos Biology. 4: e6. PMID 16300414 DOI: 10.1371/Journal.Pbio.0040006  0.692
2006 Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Correction: Corrigendum: Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization Nature Chemical Biology. 2: 346-346. DOI: 10.1038/Nchembio0606-346B  0.774
2005 Nguyen H, Jäger M, Kelly JW, Gruebele M. Engineering a beta-sheet protein toward the folding speed limit. The Journal of Physical Chemistry. B. 109: 15182-6. PMID 16852923 DOI: 10.1021/Jp052373Y  0.361
2005 Powers ET, Deechongkit S, Kelly JW. Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations. Advances in Protein Chemistry. 72: 39-78. PMID 16581372 DOI: 10.1016/S0065-3233(05)72002-7  0.796
2005 Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW. Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. Accounts of Chemical Research. 38: 911-21. PMID 16359163 DOI: 10.1021/Ar020073I  0.817
2005 Wiseman RL, Powers ET, Kelly JW. Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease. Biochemistry. 44: 16612-23. PMID 16342952 DOI: 10.1021/Bi0511484  0.809
2005 Foss TR, Wiseman RL, Kelly JW. The pathway by which the tetrameric protein transthyretin dissociates. Biochemistry. 44: 15525-33. PMID 16300401 DOI: 10.1021/Bi051608T  0.732
2005 Sawkar AR, Adamski-Werner SL, Cheng WC, Wong CH, Beutler E, Zimmer KP, Kelly JW. Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles. Chemistry & Biology. 12: 1235-44. PMID 16298303 DOI: 10.1016/J.Chembiol.2005.09.007  0.809
2005 Page LJ, Suk JY, Huff ME, Lim HJ, Venable J, Yates J, Kelly JW, Balch WE. Metalloendoprotease cleavage triggers gelsolin amyloidogenesis. The Embo Journal. 24: 4124-32. PMID 16281052 DOI: 10.1038/Sj.Emboj.7600872  0.757
2005 Fu Y, Bieschke J, Kelly JW. E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: probing the requirements for Alzheimer's amyloidogenesis. Journal of the American Chemical Society. 127: 15366-7. PMID 16262389 DOI: 10.1021/Ja0551382  0.683
2005 Green NS, Foss TR, Kelly JW. Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 14545-50. PMID 16195386 DOI: 10.1073/Pnas.0501609102  0.619
2005 Kelly JW. Structural biology: form and function instructions. Nature. 437: 486-7. PMID 16177774 DOI: 10.1038/437486A  0.34
2005 Frankenfield KN, Powers ET, Kelly JW. Influence of the N-terminal domain on the aggregation properties of the prion protein. Protein Science : a Publication of the Protein Society. 14: 2154-66. PMID 16046631 DOI: 10.1110/Ps.051434005  0.662
2005 Wiseman RL, Green NS, Kelly JW. Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis. Biochemistry. 44: 9265-74. PMID 15966751 DOI: 10.1021/Bi050352O  0.783
2005 Zhang Q, Kelly JW. Cys-10 mixed disulfide modifications exacerbate transthyretin familial variant amyloidogenicity: a likely explanation for variable clinical expression of amyloidosis and the lack of pathology in C10S/V30M transgenic mice? Biochemistry. 44: 9079-85. PMID 15966731 DOI: 10.1021/Bi050378F  0.634
2005 Deechongkit S, Powers ET, You SL, Kelly JW. Controlling the morphology of cross beta-sheet assemblies by rational design. Journal of the American Chemical Society. 127: 8562-70. PMID 15941292 DOI: 10.1021/Ja050558C  0.798
2005 Petrassi HM, Johnson SM, Purkey HE, Chiang KP, Walkup T, Jiang X, Powers ET, Kelly JW. Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state. Journal of the American Chemical Society. 127: 6662-71. PMID 15869287 DOI: 10.1021/Ja044351F  0.8
2005 Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW. Kinetic stabilization of an oligomeric protein by a single ligand binding event. Journal of the American Chemical Society. 127: 5540-51. PMID 15826192 DOI: 10.1021/Ja042929F  0.767
2005 Sekijima Y, Wiseman RL, Matteson J, Hammarström P, Miller SR, Sawkar AR, Balch WE, Kelly JW. The biological and chemical basis for tissue-selective amyloid disease. Cell. 121: 73-85. PMID 15820680 DOI: 10.1016/J.Cell.2005.01.018  0.815
2005 Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW, Futerman AH, Sussman JL. X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. The Journal of Biological Chemistry. 280: 23815-9. PMID 15817452 DOI: 10.1074/Jbc.M502799200  0.797
2005 Bieschke J, Zhang Q, Powers ET, Lerner RA, Kelly JW. Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. Biochemistry. 44: 4977-83. PMID 15794636 DOI: 10.1021/Bi0501030  0.813
2005 Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. Journal of Molecular Biology. 347: 841-54. PMID 15769474 DOI: 10.1016/J.Jmb.2005.01.050  0.718
2005 Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. Journal of Medicinal Chemistry. 48: 1576-87. PMID 15743199 DOI: 10.1021/Jm049274D  0.821
2005 Razavi H, Powers ET, Purkey HE, Adamski-Werner SL, Chiang KP, Dendle MT, Kelly JW. Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 1075-8. PMID 15686915 DOI: 10.1016/J.Bmcl.2004.12.022  0.753
2005 You S, Kelly JW. Total synthesis of didmolamides A and B Tetrahedron Letters. 46: 2567-2570. DOI: 10.1016/J.Tetlet.2005.02.097  0.576
2005 You S, Kelly JW. The total synthesis of bistratamides F–I Tetrahedron. 61: 241-249. DOI: 10.1016/J.Tet.2004.10.024  0.581
2004 Deechongkit S, Dawson PE, Kelly JW. Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations. Journal of the American Chemical Society. 126: 16762-71. PMID 15612714 DOI: 10.1021/Ja045934S  0.725
2004 Purkey HE, Palaninathan SK, Kent KC, Smith C, Safe SH, Sacchettini JC, Kelly JW. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chemistry & Biology. 11: 1719-28. PMID 15610856 DOI: 10.1016/J.Chembiol.2004.10.009  0.678
2004 Page LJ, Huff ME, Kelly JW, Balch WE. Ca2+ binding protects against gelsolin amyloidosis. Biochemical and Biophysical Research Communications. 322: 1105-10. PMID 15336957 DOI: 10.1016/J.Bbrc.2004.07.125  0.777
2004 You SL, Deechongkit S, Kelly JW. Solid-phase synthesis and stereochemical assignments of tenuecyclamides A-D employing heterocyclic amino acids derived from commercially available Fmoc alpha-amino acids. Organic Letters. 6: 2627-30. PMID 15255707 DOI: 10.1021/Ol049020M  0.77
2004 Deechongkit S, Nguyen H, Powers ET, Dawson PE, Gruebele M, Kelly JW. Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics. Nature. 430: 101-5. PMID 15229605 DOI: 10.1038/Nature02611  0.799
2004 Hurshman AR, White JT, Powers ET, Kelly JW. Transthyretin aggregation under partially denaturing conditions is a downhill polymerization. Biochemistry. 43: 7365-81. PMID 15182180 DOI: 10.1021/Bi049621L  0.741
2004 You SL, Kelly JW. Highly efficient enantiospecific synthesis of imidazoline-containing amino acids using bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate. Organic Letters. 6: 1681-3. PMID 15128266 DOI: 10.1021/Ol049439C  0.585
2004 Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 4752-7. PMID 15034169 DOI: 10.1073/Pnas.0400924101  0.817
2004 Reixach N, Deechongkit S, Jiang X, Kelly JW, Buxbaum JN. Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proceedings of the National Academy of Sciences of the United States of America. 101: 2817-22. PMID 14981241 DOI: 10.1073/Pnas.0400062101  0.772
2004 Miller SR, Sekijima Y, Kelly JW. Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants. Laboratory Investigation; a Journal of Technical Methods and Pathology. 84: 545-52. PMID 14968122 DOI: 10.1038/Labinvest.3700059  0.584
2004 Deechongkit S, You SL, Kelly JW. Synthesis of all nineteen appropriately protected chiral alpha-hydroxy acid equivalents of the alpha-amino acids for Boc solid-phase depsi-peptide synthesis. Organic Letters. 6: 497-500. PMID 14961607 DOI: 10.1021/Ol036102M  0.773
2004 Adamski-Werner SL, Palaninathan SK, Sacchettini JC, Kelly JW. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. Journal of Medicinal Chemistry. 47: 355-74. PMID 14711308 DOI: 10.1021/Jm030347N  0.387
2004 You SL, Kelly JW. Highly efficient biomimetic total synthesis and structural verification of bistratamides E and J from Lissoclinum bistratum. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 71-5. PMID 14695551 DOI: 10.1002/Chem.200305504  0.596
2003 You SL, Razavi H, Kelly JW. A biomimetic synthesis of thiazolines using hexaphenyloxodiphosphonium trifluoromethanesulfonate. Angewandte Chemie (International Ed. in English). 42: 83-5. PMID 19757597 DOI: 10.1002/Anie.200390059  0.558
2003 Kustedjo K, Deechongkit S, Kelly JW, Cravatt BF. Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA. Biochemistry. 42: 15333-41. PMID 14690443 DOI: 10.1021/Bi0349569  0.762
2003 Cohen FE, Kelly JW. Therapeutic approaches to protein-misfolding diseases. Nature. 426: 905-9. PMID 14685252 DOI: 10.1038/Nature02265  0.36
2003 Huff ME, Balch WE, Kelly JW. Pathological and functional amyloid formation orchestrated by the secretory pathway. Current Opinion in Structural Biology. 13: 674-82. PMID 14675544 DOI: 10.1016/J.Sbi.2003.10.010  0.759
2003 You SL, Kelly JW. Total synthesis of dendroamide a: oxazole and thiazole construction using an oxodiphosphonium salt. The Journal of Organic Chemistry. 68: 9506-9. PMID 14629183 DOI: 10.1021/Jo0302657  0.58
2003 Huff ME, Page LJ, Balch WE, Kelly JW. Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type. Journal of Molecular Biology. 334: 119-27. PMID 14596804 DOI: 10.1016/J.Jmb.2003.09.029  0.748
2003 Green NS, Palaninathan SK, Sacchettini JC, Kelly JW. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. Journal of the American Chemical Society. 125: 13404-14. PMID 14583036 DOI: 10.1021/Ja030294Z  0.598
2003 DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RM, Kassmann CJ, Lo TP, Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA. ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. Journal of Molecular Biology. 332: 601-15. PMID 12963370 DOI: 10.1016/S0022-2836(03)00889-1  0.816
2003 Foguel D, Suarez MC, Ferrão-Gonzales AD, Porto TC, Palmieri L, Einsiedler CM, Andrade LR, Lashuel HA, Lansbury PT, Kelly JW, Silva JL. Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities. Proceedings of the National Academy of Sciences of the United States of America. 100: 9831-6. PMID 12900507 DOI: 10.1073/Pnas.1734009100  0.604
2003 Zhang Q, Kelly JW. Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions. Biochemistry. 42: 8756-61. PMID 12873136 DOI: 10.1021/Bi030077A  0.605
2003 Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, et al. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (New York, N.Y.). 300: 2065-71. PMID 12829775 DOI: 10.1126/Science.1083182  0.716
2003 Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW. Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action. Angewandte Chemie (International Ed. in English). 42: 2758-61. PMID 12820260 DOI: 10.1002/Anie.200351179  0.789
2003 Hammarström P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland K, Garzuly F, Budka H, Kelly JW. D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? Biochemistry. 42: 6656-63. PMID 12779320 DOI: 10.1021/Bi027319B  0.813
2003 Kelly JW, Balch WE. Amyloid as a natural product. The Journal of Cell Biology. 161: 461-2. PMID 12743097 DOI: 10.1083/Jcb.200304074  0.383
2003 Ferrão-Gonzales AD, Palmieri L, Valory M, Silva JL, Lashuel H, Kelly JW, Foguel D. Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease. Journal of Molecular Biology. 328: 963-74. PMID 12729768 DOI: 10.1016/S0022-2836(03)00368-1  0.605
2003 Lu JR, Perumal S, Powers ET, Kelly JW, Webster JR, Penfold J. Adsorption of beta-hairpin peptides on the surface of water: a neutron reflection study. Journal of the American Chemical Society. 125: 3751-7. PMID 12656605 DOI: 10.1021/Ja0292290  0.568
2003 Nguyen H, Jager M, Moretto A, Gruebele M, Kelly JW. Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation. Proceedings of the National Academy of Sciences of the United States of America. 100: 3948-53. PMID 12651955 DOI: 10.1073/Pnas.0538054100  0.314
2003 Sekijima Y, Hammarström P, Matsumura M, Shimizu Y, Iwata M, Tokuda T, Ikeda S, Kelly JW. Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology. Laboratory Investigation; a Journal of Technical Methods and Pathology. 83: 409-17. PMID 12649341 DOI: 10.1097/01.Lab.0000059937.11023.1F  0.729
2003 Hammarström P, Wiseman RL, Powers ET, Kelly JW. Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science (New York, N.Y.). 299: 713-6. PMID 12560553 DOI: 10.1126/Science.1079589  0.825
2003 Colfer S, Kelly JW, Powers ET. Factors governing the self-assembly of a β-hairpin peptide at the air-water interface Langmuir. 19: 1312-1318. DOI: 10.1021/La0207668  0.58
2003 DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RM, Kassmann CJ, Lo TP, Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA. Erratum to “ALS Mutants of Human Superoxide Dismutase form Fibrous Aggregates via Framework Destabilization” [J. Mol. Biol. 332 (2003) 601–615] Journal of Molecular Biology. 334: 175. DOI: 10.1016/S0022-2836(03)01190-2  0.793
2002 Powers ET, Yang SI, Lieber CM, Kelly JW. Ordered Langmuir-Blodgett films of amphiphilic beta-hairpin peptides imaged by atomic force microscopy. Angewandte Chemie (International Ed. in English). 41: 127-30. PMID 12491460 DOI: 10.1002/1521-3773(20020104)41:1<127::Aid-Anie127>3.0.Co;2-F  0.548
2002 Sawkar AR, Cheng WC, Beutler E, Wong CH, Balch WE, Kelly JW. Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 15428-33. PMID 12434014 DOI: 10.1073/Pnas.192582899  0.8
2002 Kaul R, Deechongkit S, Kelly JW. Synthesis of a negatively charged dibenzofuran-based beta-turn mimetic and its incorporation into the WW miniprotein-enhanced solubility without a loss of thermodynamic stability. Journal of the American Chemical Society. 124: 11900-7. PMID 12358534 DOI: 10.1021/Ja020675X  0.742
2002 Hammarström P, Jiang X, Hurshman AR, Powers ET, Kelly JW. Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity. Proceedings of the National Academy of Sciences of the United States of America. 99: 16427-32. PMID 12351683 DOI: 10.1073/Pnas.202495199  0.746
2002 Sacchettini JC, Kelly JW. Therapeutic strategies for human amyloid diseases. Nature Reviews. Drug Discovery. 1: 267-75. PMID 12120278 DOI: 10.1038/Nrd769  0.341
2002 Liu K, Kelly JW, Wemmer DE. Native state hydrogen exchange study of suppressor and pathogenic variants of transthyretin. Journal of Molecular Biology. 320: 821-32. PMID 12095258 DOI: 10.1016/S0022-2836(02)00471-0  0.39
2002 McCammon MG, Scott DJ, Keetch CA, Greene LH, Purkey HE, Petrassi HM, Kelly JW, Robinson CV. Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry. Structure (London, England : 1993). 10: 851-63. PMID 12057199 DOI: 10.1016/S0969-2126(02)00771-2  0.797
2002 Deechongkit S, Kelly JW. The effect of backbone cyclization on the thermodynamics of beta-sheet unfolding: stability optimization of the PIN WW domain. Journal of the American Chemical Society. 124: 4980-6. PMID 11982361 DOI: 10.1021/Ja0123608  0.75
2002 Oza VB, Smith C, Raman P, Koepf EK, Lashuel HA, Petrassi HM, Chiang KP, Powers ET, Sachettinni J, Kelly JW. Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. Journal of Medicinal Chemistry. 45: 321-32. PMID 11784137 DOI: 10.1021/Jm010257N  0.801
2002 Jiang X, Buxbaum JN, Kelly JW. The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 98: 14943-8. PMID 11752443 DOI: 10.1073/Pnas.261419998  0.387
2002 Jiang X, Kowalski J, Kelly JW. Increasing protein stability using a rational approach combining sequence homology and structural alignment: Stabilizing the WW domain. Protein Science : a Publication of the Protein Society. 10: 1454-65. PMID 11420447 DOI: 10.1110/Ps.640101  0.348
2001 Chen CD, Huff ME, Matteson J, Page L, Phillips R, Kelly JW, Balch WE. Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization. The Embo Journal. 20: 6277-87. PMID 11707399 DOI: 10.1093/Emboj/20.22.6277  0.75
2001 White JT, Kelly JW. Support for the multigenic hypothesis of amyloidosis: the binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro. Proceedings of the National Academy of Sciences of the United States of America. 98: 13019-24. PMID 11687657 DOI: 10.1073/Pnas.241406698  0.625
2001 Hammarström P, Schneider F, Kelly JW. Trans-suppression of misfolding in an amyloid disease. Science (New York, N.Y.). 293: 2459-62. PMID 11577236 DOI: 10.1126/Science.1062245  0.647
2001 Hammarström P, Jiang X, Deechongkit S, Kelly JW. Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy. Biochemistry. 40: 11453-9. PMID 11560493 DOI: 10.1021/Bi010673+  0.802
2001 Jiang X, Smith CS, Petrassi HM, Hammarström P, White JT, Sacchettini JC, Kelly JW. An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured. Biochemistry. 40: 11442-52. PMID 11560492 DOI: 10.1021/Bi011194D  0.8
2001 Jäger M, Nguyen H, Crane JC, Kelly JW, Gruebele M. The folding mechanism of a beta-sheet: the WW domain. Journal of Molecular Biology. 311: 373-93. PMID 11478867 DOI: 10.1006/Jmbi.2001.4873  0.351
2001 Schneider F, Hammarström P, Kelly JW. Transthyretin slowly exchanges subunits under physiological conditions: A convenient chromatographic method to study subunit exchange in oligomeric proteins. Protein Science : a Publication of the Protein Society. 10: 1606-13. PMID 11468357 DOI: 10.1110/Ps.8901  0.593
2001 Kaul R, Angeles AR, Jäger M, Powers ET, Kelly JW. Incorporating beta-turns and a turn mimetic out of context in loop 1 of the WW domain affords cooperatively folded beta-sheets. Journal of the American Chemical Society. 123: 5206-12. PMID 11457382 DOI: 10.1021/Ja0102890  0.604
2001 Powers ET, Kelly JW. Medium-dependent self-assembly of an amphiphilic peptide: direct observation of peptide phase domains at the air-water interface. Journal of the American Chemical Society. 123: 775-6. PMID 11456608 DOI: 10.1021/Ja005528I  0.555
2001 Petrassi HM, Sharpless KB, Kelly JW. The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines. Organic Letters. 3: 139-42. PMID 11429858 DOI: 10.1021/Ol0003533  0.709
2001 Purkey HE, Dorrell MI, Kelly JW. Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma. Proceedings of the National Academy of Sciences of the United States of America. 98: 5566-71. PMID 11344299 DOI: 10.1073/Pnas.091431798  0.726
2001 Ratnaswamy G, Huff ME, Su AI, Rion S, Kelly JW. Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type. Proceedings of the National Academy of Sciences of the United States of America. 98: 2334-9. PMID 11226240 DOI: 10.1073/Pnas.041452598  0.753
2000 Lashuel HA, Labrenz SR, Woo L, Serpell LC, Kelly JW. Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly:  implications for amyloid fibril formation and materials science. Journal of the American Chemical Society. 122: 5262-77. PMID 22339465 DOI: 10.1021/Ja9937831  0.562
2000 Liu K, Cho HS, Hoyt DW, Nguyen TN, Olds P, Kelly JW, Wemmer DE. Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface. Journal of Molecular Biology. 303: 555-65. PMID 11054291 DOI: 10.1006/Jmbi.2000.4164  0.407
2000 Kelly JW. Mechanisms of amyloidogenesis. Nature Structural & Molecular Biology. 7: 824-826. PMID 11017183 DOI: 10.1038/82815  0.343
2000 Liu K, Cho HS, Lashuel HA, Kelly JW, Wemmer DE. A glimpse of a possible amyloidogenic intermediate of transthyretin. Nature Structural Biology. 7: 754-7. PMID 10966644 DOI: 10.1038/78980  0.606
2000 Crane JC, Koepf EK, Kelly JW, Gruebele M. Mapping the transition state of the WW domain beta-sheet. Journal of Molecular Biology. 298: 283-92. PMID 10764597 DOI: 10.1006/Jmbi.2000.3665  0.303
2000 Klabunde T, Petrassi HM, Oza VB, Raman P, Kelly JW, Sacchettini JC. Rational design of potent human transthyretin amyloid disease inhibitors. Nature Structural Biology. 7: 312-21. PMID 10742177 DOI: 10.1038/74082  0.77
2000 Kelly JW, Petrassi HM, Oza V, Purkey H, Koepf E, Raman P, Klabunde T, Sacchettini J. Structure-Based Design, Synthesis and Evaluation of Amyloid Fibril Inhibitors Biochemical Society Transactions. 28: A51-A51. DOI: 10.1042/Bst028A051  0.793
2000 Petrassi HM, Klabunde T, Sacchettini J, Kelly JW. Structure-based design of N-phenyl phenoxazine transthyretin amyloid fibril inhibitors Journal of the American Chemical Society. 122: 2178-2192. DOI: 10.1021/Ja993309V  0.765
1999 Koepf EK, Petrassi HM, Ratnaswamy G, Huff ME, Sudol M, Kelly JW. Characterization of the structure and function of W --> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding. Biochemistry. 38: 14338-51. PMID 10572009 DOI: 10.1021/bi991105l  0.795
1999 Lashuel HA, Wurth C, Woo L, Kelly JW. The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. Biochemistry. 38: 13560-73. PMID 10521263 DOI: 10.1021/Bi991021C  0.59
1999 Koo EH, Lansbury PT, Kelly JW. Amyloid diseases: abnormal protein aggregation in neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 96: 9989-90. PMID 10468546 DOI: 10.1073/Pnas.96.18.9989  0.419
1999 Baures PW, Oza VB, Peterson SA, Kelly JW. Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid. Bioorganic & Medicinal Chemistry. 7: 1339-47. PMID 10465408 DOI: 10.1016/S0968-0896(99)00066-8  0.685
1999 Ratnaswamy G, Koepf E, Bekele H, Yin H, Kelly JW. The amyloidogenicity of gelsolin is controlled by proteolysis and pH. Chemistry & Biology. 6: 293-304. PMID 10322122 DOI: 10.1016/S1074-5521(99)80075-1  0.348
1999 Koepf EK, Petrassi HM, Sudol M, Kelly JW. WW: An isolated three-stranded antiparallel beta-sheet domain that unfolds and refolds reversibly; evidence for a structured hydrophobic cluster in urea and GdnHCl and a disordered thermal unfolded state. Protein Science : a Publication of the Protein Society. 8: 841-53. PMID 10211830 DOI: 10.1110/Ps.8.4.841  0.745
1999 Chitnumsub P, Fiori WR, Lashuel HA, Diaz H, Kelly JW. The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. Bioorganic & Medicinal Chemistry. 7: 39-59. PMID 10199655 DOI: 10.1016/S0968-0896(98)00222-3  0.564
1999 Oza VB, Petrassi HM, Purkey HE, Kelly JW. Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors. Bioorganic & Medicinal Chemistry Letters. 9: 1-6. PMID 9990446 DOI: 10.1016/S0960-894X(98)00696-9  0.801
1998 Lashuel HA, Lai Z, Kelly JW. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry. 37: 17851-64. PMID 9922152 DOI: 10.1021/Bi981876+  0.6
1998 Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. Biochemistry. 37: 15177-87. PMID 9790682 DOI: 10.1021/Bi981733N  0.568
1998 Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 95: 12956-60. PMID 9789022 DOI: 10.1073/Pnas.95.22.12956  0.783
1998 Baures PW, Peterson SA, Kelly JW. Discovering transthyretin amyloid fibril inhibitors by limited screening. Bioorganic & Medicinal Chemistry. 6: 1389-401. PMID 9784876 DOI: 10.1016/S0968-0896(98)00130-8  0.725
1998 Xie Y, Lashuel HA, Miroy GJ, Dikler S, Kelly JW. Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein Expression and Purification. 14: 31-7. PMID 9758748 DOI: 10.1006/Prep.1998.0944  0.58
1998 Nettleton EJ, Sunde M, Lai Z, Kelly JW, Dobson CM, Robinson CV. Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry. Journal of Molecular Biology. 281: 553-64. PMID 9698569 DOI: 10.1006/Jmbi.1998.1937  0.407
1998 Kelly JW. The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways. Current Opinion in Structural Biology. 8: 101-6. PMID 9519302 DOI: 10.1016/S0959-440X(98)80016-X  0.427
1998 Kelly JW. The environmental dependency of protein folding best explains prion and amyloid diseases. Proceedings of the National Academy of Sciences of the United States of America. 95: 930-2. PMID 9448261 DOI: 10.1073/Pnas.95.3.930  0.433
1997 Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. Advances in Protein Chemistry. 50: 161-81. PMID 9338081 DOI: 10.1016/S0065-3233(08)60321-6  0.779
1997 Lai Z, McCulloch J, Lashuel HA, Kelly JW. Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers. Biochemistry. 36: 10230-9. PMID 9254621 DOI: 10.1021/Bi963195P  0.577
1997 Chen HI, Einbond A, Kwak SJ, Linn H, Koepf E, Peterson S, Kelly JW, Sudol M. Characterization of the WW domain of human Yes-associated protein and its polyproline-containing ligands Journal of Biological Chemistry. 272: 17070-17077. PMID 9202023 DOI: 10.1074/Jbc.272.27.17070  0.337
1997 Kelly JW. Amyloid fibril formation and protein misassembly: a structural quest for insights into amyloid and prion diseases Structure. 5: 595-600. PMID 9195890 DOI: 10.1016/S0969-2126(97)00215-3  0.429
1996 McWilliams K, Kelly JW. Synthesis and Conformational Preferences of a Potential beta-Sheet Nucleator Based on the 9,9-Dimethylxanthene Skeleton. The Journal of Organic Chemistry. 61: 7408-7414. PMID 11667668 DOI: 10.1021/Jo9605758  0.31
1996 Miroy GJ, Lai Z, Lashuel HA, Peterson SA, Strang C, Kelly JW. Inhibiting transthyretin amyloid fibril formation via protein stabilization. Proceedings of the National Academy of Sciences of the United States of America. 93: 15051-6. PMID 8986762 DOI: 10.1073/Pnas.93.26.15051  0.634
1996 Colon W, Lai Z, McCutchen SL, Miroy GJ, Strang C, Kelly JW. FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formation. Ciba Foundation Symposium. 199: 228-38; discussion 2. PMID 8915613  0.666
1996 Kelly JW. Alternative conformations of amyloidogenic proteins govern their behavior. Current Opinion in Structural Biology. 6: 11-17. PMID 8696966 DOI: 10.1016/S0959-440X(96)80089-3  0.414
1996 Lai Z, Colón W, Kelly JW. The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid. Biochemistry. 35: 6470-82. PMID 8639594 DOI: 10.1021/Bi952501G  0.679
1996 Choo DW, Schneider JP, Graciani NR, Kelly JW. Nucleated Antiparallel β-Sheet That Folds and Undergoes Self-Assembly:  A Template Promoted Folding Strategy toward Controlled Molecular Architectures Macromolecules. 29: 355-366. DOI: 10.1021/Ma950703E  0.535
1995 Graciani NR, Tsang KY, McCutchen SL, Kelly JW. Amino acids that specify structure through hydrophobic clustering and histidine-aromatic interactions lead to biologically active peptidomimetics. Bioorganic & Medicinal Chemistry. 2: 999-1006. PMID 7712134 DOI: 10.1016/S0968-0896(00)82048-9  0.313
1995 McCutchen SL, Lai Z, Miroy GJ, Kelly JW, Colón W. Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease. Biochemistry. 34: 13527-36. PMID 7577941 DOI: 10.1021/Bi00041A032  0.686
1995 Schneider JP, Kelly JW. Synthesis and Efficacy of Square Planar Copper Complexes Designed to Nucleate .beta.-Sheet Structure Journal of the American Chemical Society. 117: 2533-2546. DOI: 10.1021/Ja00114A016  0.506
1995 Schneider JP, Kelly JW. Templates That Induce .alpha.-Helical, .beta.-Sheet, and Loop Conformations Chemical Reviews. 95: 2169-2187. DOI: 10.1021/Cr00038A015  0.508
1994 McCutchen SL, Kelly JW. Intermolecular disulfide linkages are not required for transthyretin amyloid fibril formation in vitro. Biochemical and Biophysical Research Communications. 197: 415-21. PMID 8267575 DOI: 10.1006/Bbrc.1993.2495  0.41
1994 Kelly JW, Lansbury PT. A chemical approach to elucidate tin mechanism of transthyretin and βprotein amyloid fibril formation Amyloid. 1: 186-205. DOI: 10.3109/13506129409148451  0.413
1993 McCutchen SL, Colon W, Kelly JW. Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity. Biochemistry. 32: 12119-27. PMID 8218290 DOI: 10.1021/Bi00096A024  0.708
1992 Colon W, Kelly JW. Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry. 31: 8654-60. PMID 1390650 DOI: 10.1021/Bi00151A036  0.687
1992 Schneider JP, Topgi RS, Kelly JW. A Convenient Synthesis of 6,6′-Diamino-2,2′-Bipyridine Synthetic Communications. 22: 1033-1037. DOI: 10.1080/00397919208019294  0.463
1989 Kaiser ET, Mihara H, Laforet GA, Kelly JW, Walters L, Findeis MA, Sasaki T. Peptide and protein synthesis by segment synthesis-condensation. Science (New York, N.Y.). 243: 187-92. PMID 2492114 DOI: 10.1126/Science.2492114  0.544
1989 Scheim U, Rühlmann K, Kelly JW, Evans SA. Synthesis of siloxanes. XVII. Increment system for the prediction of 17O NMR shifts of siloxanes Journal of Organometallic Chemistry. 375: 33-37. DOI: 10.1016/0022-328X(89)85080-6  0.597
1988 Kelly JW. New Tools for Probing Protein Structure Nature Biotechnology. 6: 125-129. DOI: 10.1038/Nbt0288-125  0.33
1988 Rühlmann K, Scheim U, Evans SA, Kelly JW, Bassindale AR. Synthesis of siloxanes. V. Oxygen-17 NMR spectroscopy Journal of Organometallic Chemistry. 340: 19-21. DOI: 10.1016/0022-328X(88)80548-5  0.597
1987 Kelly JW, Robinson PL, Evans SA. Dioxyphosphoranes, an Emerging Class of Versatile Reagents for Organic Synthesis Phosphorous and Sulfur and the Related Elements. 30: 147-150. DOI: 10.1080/03086648708080543  0.628
1987 Robinson PL, Kelly JW, Evans SA. THE CHEMISTRY OF α, ω-MERCAPTOALCOHOLS IN THE PRESENCE OF DIETHOXYTRIPHENYLPHOSPHORANE. TEMPERATURE DEPENDENCE OF CYCLODEHYDRATIONS AND S-ETHYLATIONS Phosphorous and Sulfur and the Related Elements. 31: 59-70. DOI: 10.1080/03086648708079342  0.606
1987 Murray WT, Kelly JW, Evans SA. Synthesis of substituted 1,4-oxathianes. Mechanistic details of diethoxytriphenylphosphorane and triphenylphosphine/tetrachloromethane-promoted cyclodehydrations and carbon-13 NMR spectroscopy The Journal of Organic Chemistry. 52: 525-529. DOI: 10.1021/Jo00380A009  0.606
1987 Kelly JW, Evans SA. Oxygen-17 NMR spectral studies of selected aromatic sulfones Magnetic Resonance in Chemistry. 25: 305-308. DOI: 10.1002/Mrc.1260250406  0.605
1986 Kelly JW, Evans SA. Regioselective phosphoranylation and cyclodehydration of triols with diethoxytriphenylphosphorane. Journal of the American Chemical Society. 108: 7681-7685. PMID 22283274 DOI: 10.1021/Ja00284A036  0.604
1986 Robinson PL, Evans SA, Kelly JW. The Synthetic Utility Of Dioxyphosphoranes In Organic Synthesis Phosphorous and Sulfur and the Related Elements. 26: 15-24. DOI: 10.1080/03086648608084565  0.611
1986 Kelly JW, Evans SA. Bis(neopentyloxy)triphenylphosphorane: a versatile, nonalkylating cyclodehydration reagent The Journal of Organic Chemistry. 51: 5490-5492. DOI: 10.1021/Jo00376A103  0.591
1986 Kelly JW, Robinson PL, Evans SA. 2,2,2-Triphenyl-4,5-(2',2"-biphenylene)-1,3,2-dioxaphospholane: an effective reagent for converting diols, amino alcohols, and especially mercapto alcohols to the corresponding heterocycles The Journal of Organic Chemistry. 51: 4473-4475. DOI: 10.1021/Jo00373A026  0.588
1986 Kelly JW, Anderson NL, Evans SA. Cyclodehydration of N- and C-substituted .beta.-amino alcohols to the corresponding aziridines with diethoxytriphenylphosphorane The Journal of Organic Chemistry. 51: 95-97. DOI: 10.1021/Jo00351A020  0.615
1985 Kelly JW, Robinson PL, Evans SA. Diethoxydiphenylpolystyrylphosphorane: a new polymeric reagent for the efficient cyclodehydration of simple diols The Journal of Organic Chemistry. 50: 5007-5009. DOI: 10.1002/Chin.198621087  0.601
1985 Robinson PL, Barry CN, Kelly JW, Evans SA. Diethoxytriphenylphosphorane: a mild, regioselective cyclodehydrating reagent for conversion of diols to cyclic ethers: stereochemistry, synthetic utility, and scope Journal of the American Chemical Society. 107: 5210-5219. DOI: 10.1002/Chin.198551241  0.615
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