Giuseppe M. Attardi, M.D.
|Biology||California Institute of Technology, Pasadena, CA|
Area:Mitochondrial biogenesis, mitochondrial genetics
Discovered heterogeneous nuclear RNA in avian and mammalian cells. Discovered mtDNA transcription in mammalian cells. Showed complete symmetrical transcription of mtDNA. Made early transcript maps.
First mammalian mtDNA-less cells were created in his laboratory. Established cellular models of mitochondrial diseases.
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|Chen A, Raule N, Chomyn A, et al. (2012) Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity. Plos One. 7: e46473|
|Iwata N, Zhang J, Atzmon G, et al. (2007) Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians. Mitochondrion. 7: 267-72|
|Villani G, Attardi G. (2007) Polarographic assays of respiratory chain complex activity. Methods in Cell Biology. 80: 121-33|
|Hájek P, Chomyn A, Attardi G. (2007) Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2. The Journal of Biological Chemistry. 282: 5670-81|
|Walker DW, Hájek P, Muffat J, et al. (2006) Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. Proceedings of the National Academy of Sciences of the United States of America. 103: 16382-7|
|Duvezin-Caubet S, Jagasia R, Wagener J, et al. (2006) Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. The Journal of Biological Chemistry. 281: 37972-9|
|Martin M, Cho J, Cesare AJ, et al. (2005) Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis. Cell. 123: 1227-40|
|Fish J, Raule N, Attardi G. (2004) Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis. Science (New York, N.Y.). 306: 2098-101|
|Bai Y, Hu P, Park JS, et al. (2004) Genetic and functional analysis of mitochondrial DNA-encoded complex I genes. Annals of the New York Academy of Sciences. 1011: 272-83|
|Helm M, Attardi G. (2004) Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys). Journal of Molecular Biology. 337: 545-60|