Shamila S. Gunatilleke, Ph.D.
Affiliations: | 2007 | Chemistry: Doctor of Philosophy | University of Southern California, Los Angeles, CA, United States |
Area:
Inorganic Chemistry, Pharmaceutical Chemistry, BiochemistryGoogle:
"Shamila Gunatilleke"Parents
Sign in to add mentor| Amy M. Barrios | grad student | 2007 | USC | |
| (Inhibition of cysteine proteases by gold(I) complexes: A kinetic and mechanistic investigation.) | ||||
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Publications
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| Choi JY, Calvet CM, Vieira DF, et al. (2014) R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. Acs Medicinal Chemistry Letters. 5: 434-9 |
| Choi JY, Calvet CM, Gunatilleke SS, et al. (2013) Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. Journal of Medicinal Chemistry. 56: 7651-68 |
| Choy JW, Bryant C, Calvet CM, et al. (2013) Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein Journal of Organic Chemistry. 9: 15-25 |
| Debnath A, Parsonage D, Andrade RM, et al. (2012) A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine. 18: 956-60 |
| Carlson JC, Li S, Gunatilleke SS, et al. (2011) Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. Nature Chemistry. 3: 628-33 |
| Gunatilleke SS, de Oliveira CA, McCammon JA, et al. (2008) Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 555-61 |
| Gunatilleke SS, Barrios AM. (2008) Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions. Journal of Inorganic Biochemistry. 102: 555-63 |
| Gunatilleke SS, Barrios AM. (2006) Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes: a detailed mechanistic investigation. Journal of Medicinal Chemistry. 49: 3933-7 |