Cheryl Arrowsmith

Medical Biophysics University of Toronto, Toronto, ON, Canada 
General Biophysics, Biochemistry
"Cheryl Arrowsmith"
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Guegueniat J, Halabelian L, Zeng H, et al. (2021) The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface. Nucleic Acids Research
Saraon P, Snider J, Schormann W, et al. (2021) Chemical genetics screen identifies COPB2 tool compounds that alters ER stress response and induces RTK dysregulation in lung cancer cells. Journal of Molecular Biology. 167294
Mann MK, Zepeda-Velázquez CA, González-Álvarez H, et al. (2021) Structure-Activity Relationship of USP5 Inhibitors. Journal of Medicinal Chemistry
Lourenco C, Resetca D, Redel C, et al. (2021) MYC protein interactors in gene transcription and cancer. Nature Reviews. Cancer
Gradl S, Steuber H, Weiske J, et al. (2021) Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening. Slas Discovery : Advancing Life Sciences R & D. 24725552211019409
Resetca D, MacDonald AS, Kenney TMG, et al. (2021) Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies. Methods in Molecular Biology (Clifton, N.J.). 2318: 45-67
Dölle A, Adhikari B, Krämer A, et al. (2021) Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry
Wu Q, Schapira M, Arrowsmith CH, et al. (2021) Protein arginine methylation: from enigmatic functions to therapeutic targeting. Nature Reviews. Drug Discovery
Shen Y, Li F, Szewczyk MM, et al. (2021) A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of Medicinal Chemistry
Sachamitr P, Ho JC, Ciamponi FE, et al. (2021) PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature Communications. 12: 979
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