| Year |
Citation |
Score |
| 2024 |
Cech TR, Davidovich C, Jenner RG. PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner. Molecular Cell. 84: 3593-3595. PMID 39366348 DOI: 10.1016/j.molcel.2024.09.010 |
0.758 |
|
| 2024 |
Song J, Yao L, Gooding AR, Thron V, Kasinath V, Cech TR. Diverse RNA Structures Induce PRC2 Dimerization and Inhibit Histone Methyltransferase Activity. Biorxiv : the Preprint Server For Biology. PMID 39257770 DOI: 10.1101/2024.08.29.610323 |
0.433 |
|
| 2024 |
Johnson K, Seidel JM, Cech TR. Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis. Rna (New York, N.Y.). PMID 38918043 DOI: 10.1261/rna.080043.124 |
0.354 |
|
| 2024 |
Cai SW, Takai H, Zaug AJ, Dilgen TC, Cech TR, Walz T, de Lange T. POT1 recruits and regulates CST-Polα/primase at human telomeres. Cell. PMID 38838667 DOI: 10.1016/j.cell.2024.05.002 |
0.334 |
|
| 2024 |
Hemphill WO, Steiner HR, Kominsky JR, Wuttke DS, Cech TR. Transcription factors ERα and Sox2 have differing multiphasic DNA and RNA binding mechanisms. Rna (New York, N.Y.). PMID 38760076 DOI: 10.1261/rna.080027.124 |
0.401 |
|
| 2024 |
Hemphill WO, Steiner HR, Kominsky JR, Wuttke DS, Cech TR. Transcription factors ERα and Sox2 have differing multiphasic DNA and RNA binding mechanisms. Biorxiv : the Preprint Server For Biology. PMID 38562825 DOI: 10.1101/2024.03.18.585577 |
0.401 |
|
| 2023 |
Forino NM, Woo JZ, Zaug AJ, Jimenez AG, Cech TR, Rouskin S, Stone MD. Dissecting telomerase RNA structural heterogeneity in living human cells with DMS-MaPseq. Biorxiv : the Preprint Server For Biology. PMID 37873413 DOI: 10.1101/2023.10.04.560962 |
0.475 |
|
| 2023 |
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science (New York, N.Y.). 381: 1331-1337. PMID 37733873 DOI: 10.1126/science.adh0059 |
0.465 |
|
| 2023 |
Long Y, Hwang T, Gooding AR, Goodrich KJ, Vallery TK, Rinn JL, Cech TR. Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells. Biorxiv : the Preprint Server For Biology. PMID 37645830 DOI: 10.1101/2023.08.17.553776 |
0.41 |
|
| 2023 |
Hemphill WO, Voong CK, Fenske R, Goodrich JA, Cech TR. Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220537120. PMID 37339225 DOI: 10.1073/pnas.2220537120 |
0.396 |
|
| 2023 |
Hemphill WO, Fenske R, Gooding AR, Cech TR. PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220528120. PMID 37252986 DOI: 10.1073/pnas.2220528120 |
0.417 |
|
| 2023 |
Song J, Gooding AR, Hemphill WO, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Biorxiv : the Preprint Server For Biology. PMID 36798278 DOI: 10.1101/2023.02.06.527314 |
0.463 |
|
| 2022 |
Jansson-Fritzberg LI, Sousa CI, Smallegan MJ, Song JJ, Gooding AR, Kasinath V, Rinn JL, Cech TR. DNMT1 inhibition by pUG-fold quadruplex RNA. Rna (New York, N.Y.). PMID 36574982 DOI: 10.1261/rna.079479.122 |
0.46 |
|
| 2022 |
Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR. Reconstitution of a telomeric replicon organized by CST. Nature. 608: 819-825. PMID 35831508 DOI: 10.1038/s41586-022-04930-8 |
0.355 |
|
| 2022 |
Cech TR. RNA in biological condensates. Rna (New York, N.Y.). 28: 1-2. PMID 34903621 DOI: 10.1261/rna.079051.121 |
0.378 |
|
| 2021 |
Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Research. PMID 34718732 DOI: 10.1093/nar/gkab942 |
0.791 |
|
| 2021 |
Dumbović G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Publisher Correction: Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nature Communications. 12: 6189. PMID 34675241 DOI: 10.1038/s41467-021-26492-5 |
0.781 |
|
| 2021 |
Agarwal N, Rinaldetti S, Cheikh BB, Zhou Q, Hass EP, Jones RT, Joshi M, LaBarbera DV, Knott SRV, Cech TR, Theodorescu D. TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34518220 DOI: 10.1073/pnas.2102423118 |
0.777 |
|
| 2021 |
Dumbović G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nature Communications. 12: 3308. PMID 34083519 DOI: 10.1038/s41467-021-23221-w |
0.833 |
|
| 2021 |
Lim CJ, Cech TR. Publisher Correction: Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nature Reviews. Molecular Cell Biology. PMID 33608692 DOI: 10.1038/s41580-021-00353-x |
0.737 |
|
| 2021 |
Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nature Reviews. Molecular Cell Biology. PMID 33564154 DOI: 10.1038/s41580-021-00328-y |
0.785 |
|
| 2020 |
Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR. RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nature Genetics. PMID 32632336 DOI: 10.1038/S41588-020-0662-X |
0.511 |
|
| 2020 |
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science (New York, N.Y.). 368: 1081-1085. PMID 32499435 DOI: 10.1126/Science.Aaz9649 |
0.801 |
|
| 2020 |
Heenan PR, Wang X, Gooding AR, Cech TR, Perkins TT. Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid. Nucleic Acids Research. PMID 32043141 DOI: 10.1093/Nar/Gkaa073 |
0.378 |
|
| 2019 |
Rowland TJ, Dumbović G, Hass EP, Rinn JL, Cech TR. Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines. Proceedings of the National Academy of Sciences of the United States of America. PMID 31451652 DOI: 10.1073/Pnas.1908275116 |
0.794 |
|
| 2019 |
Wang X, Goodrich KJ, Conlon EG, Gao J, Erbse AH, Manley JL, Cech TR. C9orf72 and Triplet Repeat Disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms. Rna (New York, N.Y.). PMID 31048495 DOI: 10.1261/Rna.071191.119 |
0.523 |
|
| 2018 |
Cech TR. A Lifelong Passion for All Things Ribonucleic. Cell. 175: 14-17. PMID 30217358 DOI: 10.1016/J.Cell.2018.08.037 |
0.403 |
|
| 2018 |
Greenwood J, Patel H, Cech TR, Cooper JP. Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA. Nucleic Acids Research. PMID 29992245 DOI: 10.1093/Nar/Gky605 |
0.683 |
|
| 2018 |
Shoffner GM, Wang R, Podell E, Cech TR, Guo F. In Crystallo Selection to Establish New RNA Crystal Contacts. Structure (London, England : 1993). PMID 29910185 DOI: 10.1016/J.Str.2018.05.005 |
0.548 |
|
| 2018 |
Youmans DT, Schmidt JC, Cech TR. Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits. Genes & Development. PMID 29891558 DOI: 10.1101/Gad.311936.118 |
0.325 |
|
| 2018 |
Schmidt JC, Zaug AJ, Kufer R, Cech TR. Dynamics of human telomerase recruitment depend on template- telomere base pairing. Molecular Biology of the Cell. PMID 29386295 DOI: 10.1091/Mbc.E17-11-0637 |
0.411 |
|
| 2017 |
Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X. Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2. Elife. 6. PMID 29185984 DOI: 10.7554/Elife.31558 |
0.542 |
|
| 2017 |
Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nature Structural & Molecular Biology. PMID 29058709 DOI: 10.1038/Nsmb.3487 |
0.493 |
|
| 2017 |
Lim CJ, Zaug AJ, Kim HJ, Cech TR. Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity. Nature Communications. 8: 1075. PMID 29057866 DOI: 10.1038/S41467-017-01313-W |
0.798 |
|
| 2017 |
Long Y, Wang X, Youmans DT, Cech TR. How do lncRNAs regulate transcription? Science Advances. 3: eaao2110. PMID 28959731 DOI: 10.1126/Sciadv.Aao2110 |
0.477 |
|
| 2017 |
Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C. Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines. Molecular Cell. 65: 1056-1067.e5. PMID 28306504 DOI: 10.1016/J.Molcel.2017.02.003 |
0.795 |
|
| 2017 |
Goldfarb KC, Cech TR. Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing. Genes & Development. 31: 59-71. PMID 28115465 DOI: 10.1101/Gad.286963.116 |
0.51 |
|
| 2017 |
Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X. Author response: Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2 Elife. DOI: 10.7554/Elife.31558.021 |
0.444 |
|
| 2016 |
Schmidt JC, Zaug AJ, Cech TR. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres. Cell. PMID 27523609 DOI: 10.1016/J.Cell.2016.07.033 |
0.373 |
|
| 2016 |
Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. PMID 27180905 DOI: 10.1016/J.Cell.2016.04.028 |
0.789 |
|
| 2016 |
Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nature Structural & Molecular Biology. PMID 26950371 DOI: 10.1038/Nsmb.3184 |
0.474 |
|
| 2015 |
Xi L, Cech TR. Protein-RNA interaction restricts telomerase from running through the stop sign. Nature Structural & Molecular Biology. 22: 835-6. PMID 26581514 DOI: 10.1038/Nsmb.3118 |
0.545 |
|
| 2015 |
Davidovich C, Cech TR. The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2. Rna (New York, N.Y.). 21: 2007-22. PMID 26574518 DOI: 10.1261/Rna.053918.115 |
0.785 |
|
| 2015 |
Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression. Genome Biology. 16: 231. PMID 26553065 DOI: 10.1186/S13059-015-0791-1 |
0.367 |
|
| 2015 |
Wang X, Schwartz JC, Cech TR. Nucleic acid-binding specificity of human FUS protein. Nucleic Acids Research. 43: 7535-43. PMID 26150427 DOI: 10.1093/Nar/Gkv679 |
0.76 |
|
| 2015 |
Schmidt JC, Cech TR. Human telomerase: biogenesis, trafficking, recruitment, and activation. Genes & Development. 29: 1095-1105. PMID 26063571 DOI: 10.1101/Gad.263863.115 |
0.387 |
|
| 2015 |
Cech TR. RNA World research-still evolving. Rna (New York, N.Y.). 21: 474-5. PMID 25780099 DOI: 10.1261/Rna.049965.115 |
0.547 |
|
| 2015 |
Borah S, Xi L, Zaug AJ, Powell NM, Dancik GM, Cohen SB, Costello JC, Theodorescu D, Cech TR. Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer. Science (New York, N.Y.). 347: 1006-10. PMID 25722414 DOI: 10.1126/Science.1260200 |
0.351 |
|
| 2015 |
Dalby AB, Hofr C, Cech TR. Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. Journal of Molecular Biology. 427: 1291-303. PMID 25623306 DOI: 10.1016/J.Jmb.2015.01.008 |
0.79 |
|
| 2015 |
Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Molecular Cell. 57: 552-8. PMID 25601759 DOI: 10.1016/J.Molcel.2014.12.017 |
0.79 |
|
| 2015 |
Schwartz JC, Cech TR, Parker RR. Biochemical Properties and Biological Functions of FET Proteins. Annual Review of Biochemistry. 84: 355-79. PMID 25494299 DOI: 10.1146/Annurev-Biochem-060614-034325 |
0.762 |
|
| 2015 |
Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z. Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. Journal of Cell Science. 128: 331-41. PMID 25416818 DOI: 10.1242/Jcs.159467 |
0.394 |
|
| 2014 |
Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 3. PMID 25271372 DOI: 10.7554/Elife.03563 |
0.795 |
|
| 2014 |
Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR. FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Molecular Biology of the Cell. 25: 2571-8. PMID 25009283 DOI: 10.1091/Mbc.E14-05-1007 |
0.734 |
|
| 2014 |
Davidovich C, Goodrich KJ, Gooding AR, Cech TR. A dimeric state for PRC2. Nucleic Acids Research. 42: 9236-48. PMID 24992961 DOI: 10.1093/Nar/Gku540 |
0.787 |
|
| 2014 |
Xi L, Cech TR. Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT. Nucleic Acids Research. 42: 8565-77. PMID 24990373 DOI: 10.1093/Nar/Gku560 |
0.445 |
|
| 2014 |
Cech TR, Steitz JA. The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 157: 77-94. PMID 24679528 DOI: 10.1016/J.Cell.2014.03.008 |
0.522 |
|
| 2014 |
McKay DB, Xi L, Barthel KK, Cech TR. Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. Journal of Molecular Biology. 426: 1766-85. PMID 24486609 DOI: 10.1016/J.Jmb.2014.01.006 |
0.543 |
|
| 2014 |
Theodorescu D, Cech TR. Telomerase in bladder cancer: back to a better future? European Urology. 65: 370-1. PMID 24184027 DOI: 10.1016/J.Eururo.2013.10.019 |
0.513 |
|
| 2014 |
Schmidt JC, Dalby AB, Cech TR. Author response: Identification of human TERT elements necessary for telomerase recruitment to telomeres Elife. DOI: 10.7554/Elife.03563.020 |
0.748 |
|
| 2013 |
Schwartz JC, Wang X, Podell ER, Cech TR. RNA seeds higher-order assembly of FUS protein. Cell Reports. 5: 918-25. PMID 24268778 DOI: 10.1016/J.Celrep.2013.11.017 |
0.773 |
|
| 2013 |
Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. The Journal of Biological Chemistry. 288: 33171-80. PMID 24097987 DOI: 10.1074/Jbc.M113.518175 |
0.322 |
|
| 2013 |
Davidovich C, Zheng L, Goodrich KJ, Cech TR. Promiscuous RNA binding by Polycomb repressive complex 2. Nature Structural & Molecular Biology. 20: 1250-7. PMID 24077223 DOI: 10.1038/Nsmb.2679 |
0.78 |
|
| 2013 |
Goldfarb KC, Cech TR. 3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing. Bmc Molecular Biology. 14: 23. PMID 24053768 DOI: 10.1186/1471-2199-14-23 |
0.52 |
|
| 2013 |
Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Research. 41: 8969-78. PMID 23901009 DOI: 10.1093/Nar/Gkt653 |
0.402 |
|
| 2013 |
Dalby AB, Goodrich KJ, Pfingsten JS, Cech TR. RNA recognition by the DNA end-binding Ku heterodimer. Rna (New York, N.Y.). 19: 841-51. PMID 23610127 DOI: 10.1261/Rna.038703.113 |
0.839 |
|
| 2013 |
Cech T, Steele F. The (noncoding) RNA world Nucleic Acid Therapeutics. 23: 1. PMID 23350901 DOI: 10.1089/nat.2013.1501 |
0.37 |
|
| 2013 |
Nandakumar J, Cech TR. Finding the end: recruitment of telomerase to telomeres. Nature Reviews. Molecular Cell Biology. 14: 69-82. PMID 23299958 DOI: 10.1038/Nrm3505 |
0.438 |
|
| 2013 |
Cech TR. How a chemist looks at RNA. Angewandte Chemie (International Ed. in English). 52: 75-8. PMID 23203538 DOI: 10.1002/Anie.201205427 |
0.478 |
|
| 2012 |
Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR. FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes & Development. 26: 2690-5. PMID 23249733 DOI: 10.1101/Gad.204602.112 |
0.765 |
|
| 2012 |
Berman AJ, Cech TR. SnapShot: telomeres and telomerase. Cell. 151: 1138-1138.e1. PMID 23178129 DOI: 10.1016/J.Cell.2012.11.008 |
0.654 |
|
| 2012 |
Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 492: 285-9. PMID 23103865 DOI: 10.1038/Nature11648 |
0.469 |
|
| 2012 |
Goldfarb KC, Borah S, Cech TR. RNase P branches out from RNP to protein: organelle-triggered diversification? Genes & Development. 26: 1005-9. PMID 22588715 DOI: 10.1101/Gad.193581.112 |
0.374 |
|
| 2012 |
Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR. Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell. 148: 922-32. PMID 22365814 DOI: 10.1016/J.Cell.2012.01.033 |
0.531 |
|
| 2012 |
Nandakumar J, Cech TR. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Research. 40: 235-44. PMID 21911358 DOI: 10.1093/Nar/Gkr721 |
0.529 |
|
| 2012 |
Cech TR. The RNA worlds in context. Cold Spring Harbor Perspectives in Biology. 4: a006742. PMID 21441585 DOI: 10.1101/Cshperspect.A006742 |
0.48 |
|
| 2012 |
Cech TR. Die RNA aus der Sicht eines Chemikers Angewandte Chemie. 125: 78-82. DOI: 10.1002/Ange.201205427 |
0.462 |
|
| 2011 |
Berman AJ, Akiyama BM, Stone MD, Cech TR. The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nature Structural & Molecular Biology. 18: 1371-5. PMID 22101935 DOI: 10.1038/Nsmb.2174 |
0.773 |
|
| 2011 |
Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, et al. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 474: 399-402. PMID 21602826 DOI: 10.1038/Nature10084 |
0.302 |
|
| 2011 |
Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. Journal of Molecular Biology. 410: 10-7. PMID 21596049 DOI: 10.1016/J.Jmb.2011.04.049 |
0.619 |
|
| 2011 |
Zappulla DC, Goodrich KJ, Arthur JR, Gurski LA, Denham EM, Stellwagen AE, Cech TR. Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP. Rna (New York, N.Y.). 17: 298-311. PMID 21177376 DOI: 10.1261/Rna.2483611 |
0.797 |
|
| 2010 |
Berman AJ, Gooding AR, Cech TR. Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Molecular and Cellular Biology. 30: 4965-76. PMID 20713447 DOI: 10.1128/Mcb.00827-10 |
0.686 |
|
| 2010 |
Zaug AJ, Podell ER, Nandakumar J, Cech TR. Functional interaction between telomere protein TPP1 and telomerase. Genes & Development. 24: 613-22. PMID 20231318 DOI: 10.1101/Gad.1881810 |
0.449 |
|
| 2010 |
Qiao F, Goodrich KJ, Cech TR. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proceedings of the National Academy of Sciences of the United States of America. 107: 4914-8. PMID 20194781 DOI: 10.1073/Pnas.0909366107 |
0.542 |
|
| 2010 |
Latrick CM, Cech TR. POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. The Embo Journal. 29: 924-33. PMID 20094033 DOI: 10.1038/Emboj.2009.409 |
0.814 |
|
| 2010 |
Nandakumar J, Podell ER, Cech TR. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America. 107: 651-6. PMID 20080730 DOI: 10.1073/Pnas.0911099107 |
0.579 |
|
| 2009 |
Cech TR. Evolution of biological catalysis: ribozyme to RNP enzyme. Cold Spring Harbor Symposia On Quantitative Biology. 74: 11-6. PMID 19850851 DOI: 10.1101/Sqb.2009.74.024 |
0.481 |
|
| 2009 |
Cech TR. Crawling out of the RNA world. Cell. 136: 599-602. PMID 19239881 DOI: 10.1016/J.Cell.2009.02.002 |
0.393 |
|
| 2009 |
Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nature Chemical Biology. 5: 97-9. PMID 19125157 DOI: 10.1038/Nchembio.136 |
0.514 |
|
| 2009 |
Zappulla DC, Roberts JN, Goodrich KJ, Cech TR, Wuttke DS. Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic Acids Research. 37: 354-67. PMID 19043074 DOI: 10.1093/Nar/Gkn830 |
0.766 |
|
| 2008 |
Vicens Q, Paukstelis PJ, Westhof E, Lambowitz AM, Cech TR. Toward predicting self-splicing and protein-facilitated splicing of group I introns. Rna (New York, N.Y.). 14: 2013-29. PMID 18768647 DOI: 10.1261/Rna.1027208 |
0.41 |
|
| 2008 |
Zaug AJ, Podell ER, Cech TR. Mutation in TERT separates processivity from anchor-site function. Nature Structural & Molecular Biology. 15: 870-2. PMID 18641663 DOI: 10.1038/Nsmb.1462 |
0.415 |
|
| 2008 |
Qiao F, Cech TR. Triple-helix structure in telomerase RNA contributes to catalysis. Nature Structural & Molecular Biology. 15: 634-40. PMID 18500353 DOI: 10.1038/Nsmb.1420 |
0.586 |
|
| 2008 |
Mozdy AD, Podell ER, Cech TR. Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance. Molecular and Cellular Biology. 28: 4152-61. PMID 18411302 DOI: 10.1128/Mcb.00512-08 |
0.508 |
|
| 2007 |
Cech TR. On the occasion of the 25th anniversary of the discovery of catalytic RNA. Biological Chemistry. 388: 661-2. PMID 17570816 DOI: 10.1515/Bc.2007.084 |
0.45 |
|
| 2007 |
Vicens Q, Gooding AR, Laederach A, Cech TR. Local RNA structural changes induced by crystallization are revealed by SHAPE. Rna (New York, N.Y.). 13: 536-48. PMID 17299128 DOI: 10.1261/Rna.400207 |
0.359 |
|
| 2007 |
Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature. 445: 506-10. PMID 17237768 DOI: 10.1038/Nature05454 |
0.557 |
|
| 2006 |
Zappulla DC, Cech TR. RNA as a flexible scaffold for proteins: yeast telomerase and beyond. Cold Spring Harbor Symposia On Quantitative Biology. 71: 217-24. PMID 17381300 DOI: 10.1101/Sqb.2006.71.011 |
0.818 |
|
| 2006 |
Mozdy AD, Cech TR. Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency. Rna (New York, N.Y.). 12: 1721-37. PMID 16894218 DOI: 10.1261/Rna.134706 |
0.547 |
|
| 2006 |
Jacobs SA, Podell ER, Cech TR. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nature Structural & Molecular Biology. 13: 218-25. PMID 16462747 DOI: 10.1038/Nsmb1054 |
0.521 |
|
| 2006 |
Guo F, Gooding AR, Cech TR. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. Rna (New York, N.Y.). 12: 387-95. PMID 16431981 DOI: 10.1261/Rna.2198206 |
0.543 |
|
| 2006 |
Vicens Q, Cech TR. Atomic level architecture of group I introns revealed. Trends in Biochemical Sciences. 31: 41-51. PMID 16356725 DOI: 10.1016/J.Tibs.2005.11.008 |
0.326 |
|
| 2006 |
Cech TR, Moras D, Nagai K, Williamson JR. 11 The RNP World Cold Spring Harbor Monograph Archive. 43: 309-326. DOI: 10.1101/087969739.43.309 |
0.67 |
|
| 2006 |
Zappulla DC, Goodrich K, Cech TR. Erratum: Corrigendum: A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro Nature Structural & Molecular Biology. 13: 465-465. DOI: 10.1038/Nsmb0506-465A |
0.783 |
|
| 2005 |
Zappulla DC, Goodrich K, Cech TR. A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nature Structural & Molecular Biology. 12: 1072-7. PMID 16299517 DOI: 10.1038/Nsmb1019 |
0.813 |
|
| 2005 |
Jacobs SA, Podell ER, Wuttke DS, Cech TR. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Science : a Publication of the Protein Society. 14: 2051-8. PMID 16046627 DOI: 10.1110/Ps.051532105 |
0.355 |
|
| 2005 |
Zaug AJ, Podell ER, Cech TR. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proceedings of the National Academy of Sciences of the United States of America. 102: 10864-9. PMID 16043710 DOI: 10.1073/Pnas.0504744102 |
0.444 |
|
| 2005 |
Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. The Journal of Biological Chemistry. 280: 32069-80. PMID 16030011 DOI: 10.1074/Jbc.M505211200 |
0.547 |
|
| 2005 |
Lei M, Zaug AJ, Podell ER, Cech TR. Switching human telomerase on and off with hPOT1 protein in vitro. The Journal of Biological Chemistry. 280: 20449-56. PMID 15792951 DOI: 10.1074/Jbc.M502212200 |
0.563 |
|
| 2005 |
Mandell JG, Bähler J, Volpe TA, Martienssen RA, Cech TR. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biology. 6: R1. PMID 15642092 DOI: 10.1186/Gb-2004-6-1-R1 |
0.36 |
|
| 2005 |
Mandell JG, Goodrich KJ, Bähler J, Cech TR. Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. The Journal of Biological Chemistry. 280: 5249-57. PMID 15591066 DOI: 10.1074/Jbc.M412756200 |
0.467 |
|
| 2004 |
Cech TR. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Bioscience Reports. 24: 362-85. PMID 16134019 DOI: 10.1007/S10540-005-2738-3 |
0.477 |
|
| 2004 |
Lei M, Podell ER, Cech TR. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nature Structural & Molecular Biology. 11: 1223-9. PMID 15558049 DOI: 10.1038/Nsmb867 |
0.555 |
|
| 2004 |
Guo F, Gooding AR, Cech TR. Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Molecular Cell. 16: 351-62. PMID 15525509 DOI: 10.1016/J.Molcel.2004.10.003 |
0.571 |
|
| 2004 |
Zappulla DC, Cech TR. Yeast telomerase RNA: a flexible scaffold for protein subunits. Proceedings of the National Academy of Sciences of the United States of America. 101: 10024-9. PMID 15226497 DOI: 10.1073/Pnas.0403641101 |
0.816 |
|
| 2004 |
Aigner S, Cech TR. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. Rna (New York, N.Y.). 10: 1108-18. PMID 15208446 DOI: 10.1261/Rna.7400704 |
0.71 |
|
| 2004 |
Cech TR. RNA finds a simpler way. Nature. 428: 263-4. PMID 15029175 DOI: 10.1038/428263A |
0.481 |
|
| 2004 |
Cech TR. Beginning to understand the end of the chromosome. Cell. 116: 273-9. PMID 14744437 DOI: 10.1016/S0092-8674(04)00038-8 |
0.429 |
|
| 2003 |
Lei M, Podell ER, Baumann P, Cech TR. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature. 426: 198-203. PMID 14614509 DOI: 10.1038/Nature02092 |
0.704 |
|
| 2003 |
Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR. A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. Rna (New York, N.Y.). 9: 1323-32. PMID 14561882 DOI: 10.1261/Rna.5570803 |
0.813 |
|
| 2003 |
Bryan TM, Goodrich KJ, Cech TR. Tetrahymena telomerase is active as a monomer. Molecular Biology of the Cell. 14: 4794-804. PMID 13679509 DOI: 10.1091/Mbc.E03-07-0474 |
0.762 |
|
| 2003 |
Classen S, Lyons D, Cech TR, Schultz SC. Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit. Biochemistry. 42: 9269-77. PMID 12899613 DOI: 10.1021/Bi0273718 |
0.727 |
|
| 2003 |
Colgin LM, Baran K, Baumann P, Cech TR, Reddel RR. Human POT1 facilitates telomere elongation by telomerase. Current Biology : Cb. 13: 942-6. PMID 12781132 DOI: 10.1016/S0960-9822(03)00339-7 |
0.648 |
|
| 2003 |
Aigner S, Postberg J, Lipps HJ, Cech TR. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 42: 5736-47. PMID 12741831 DOI: 10.1021/Bi034121Y |
0.735 |
|
| 2003 |
Förstemann K, Zaug AJ, Cech TR, Lingner J. Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Research. 31: 1646-55. PMID 12626706 DOI: 10.1093/Nar/Gkg261 |
0.751 |
|
| 2003 |
Friedman KL, Heit JJ, Long DM, Cech TR. N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex. Molecular Biology of the Cell. 14: 1-13. PMID 12529422 DOI: 10.1091/Mbc.E02-06-0327 |
0.723 |
|
| 2002 |
Lei M, Baumann P, Cech TR. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry. 41: 14560-8. PMID 12463756 DOI: 10.1021/Bi026674Z |
0.666 |
|
| 2002 |
Cech TR. Ribozymes, the first 20 years. Biochemical Society Transactions. 30: 1162-6. PMID 12440996 DOI: 10.1042/Bst0301162 |
0.467 |
|
| 2002 |
Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes & Development. 16: 2800-12. PMID 12414733 DOI: 10.1101/Gad.1029302 |
0.842 |
|
| 2002 |
Baumann P, Podell E, Cech TR. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Molecular and Cellular Biology. 22: 8079-87. PMID 12391173 DOI: 10.1128/Mcb.22.22.8079-8087.2002 |
0.646 |
|
| 2002 |
Guo F, Cech TR. Evolution of Tetrahymena ribozyme mutants with increased structural stability. Nature Structural Biology. 9: 855-61. PMID 12368901 DOI: 10.1038/Nsb850 |
0.541 |
|
| 2002 |
Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 418: 222-8. PMID 12110898 DOI: 10.1038/418222A |
0.622 |
|
| 2002 |
Guo F, Cech TR. In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. Rna (New York, N.Y.). 8: 647-58. PMID 12022231 DOI: 10.1017/S1355838202029011 |
0.498 |
|
| 2002 |
Livengood AJ, Zaug AJ, Cech TR. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Molecular and Cellular Biology. 22: 2366-74. PMID 11884619 DOI: 10.1128/Mcb.22.7.2366-2374.2002 |
0.857 |
|
| 2002 |
Jarstfer MB, Cech TR. Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation. Biochemistry. 41: 151-61. PMID 11772012 DOI: 10.1021/Bi011649Z |
0.751 |
|
| 2001 |
Cohen SB, Cech TR. Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 5.1. PMID 18428857 DOI: 10.1002/0471142700.Nc0501S00 |
0.408 |
|
| 2001 |
Sperger JM, Cech TR. A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity. Biochemistry. 40: 7005-16. PMID 11401544 DOI: 10.1021/Bi0103359 |
0.802 |
|
| 2001 |
Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (New York, N.Y.). 292: 1171-5. PMID 11349150 DOI: 10.1126/Science.1060036 |
0.609 |
|
| 2001 |
Juneau K, Podell E, Harrington DJ, Cech TR. Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions. Structure (London, England : 1993). 9: 221-31. PMID 11286889 DOI: 10.1016/S0969-2126(01)00579-2 |
0.833 |
|
| 2001 |
Silverman SK, Cech TR. An early transition state for folding of the P4-P6 RNA domain. Rna (New York, N.Y.). 7: 161-6. PMID 11233973 DOI: 10.1017/S1355838201001716 |
0.638 |
|
| 2000 |
Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. The Embo Journal. 19: 6230-9. PMID 11080168 DOI: 10.1093/Emboj/19.22.6230 |
0.803 |
|
| 2000 |
Baumann P, Cech TR. Protection of telomeres by the Ku protein in fission yeast. Molecular Biology of the Cell. 11: 3265-75. PMID 11029034 DOI: 10.1091/Mbc.11.10.3265 |
0.598 |
|
| 2000 |
Silverman SK, Deras ML, Woodson SA, Scaringe SA, Cech TR. Multiple folding pathways for the P4-P6 RNA domain. Biochemistry. 39: 12465-75. PMID 11015228 DOI: 10.1021/Bi000828Y |
0.721 |
|
| 2000 |
Bryan TM, Goodrich KJ, Cech TR. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Molecular Cell. 6: 493-9. PMID 10983995 DOI: 10.1016/S1097-2765(00)00048-4 |
0.766 |
|
| 2000 |
Cech TR. Structural biology. The ribosome is a ribozyme. Science (New York, N.Y.). 289: 878-9. PMID 10960319 DOI: 10.1126/Science.289.5481.878 |
0.415 |
|
| 2000 |
Haering CH, Nakamura TM, Baumann P, Cech TR. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Proceedings of the National Academy of Sciences of the United States of America. 97: 6367-72. PMID 10829083 DOI: 10.1073/Pnas.130187397 |
0.697 |
|
| 2000 |
Bryan TM, Goodrich KJ, Cech TR. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. The Journal of Biological Chemistry. 275: 24199-207. PMID 10807925 DOI: 10.1074/Jbc.M003246200 |
0.697 |
|
| 2000 |
Cech TR. Life at the End of the Chromosome: Telomeres and Telomerase. Angewandte Chemie (International Ed. in English). 39: 34-43. PMID 10649348 DOI: 10.1002/(Sici)1521-3773(20000103)39:1<34::Aid-Anie34>3.0.Co;2-N |
0.325 |
|
| 2000 |
Cech TR. Leben am Ende der Chromosomen: Telomere und Telomerase Angewandte Chemie. 112: 34-44. DOI: 10.1002/(Sici)1521-3757(20000103)112:1<34::Aid-Ange34>3.0.Co;2-2 |
0.35 |
|
| 1999 |
Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR. Quantifying the energetic interplay of RNA tertiary and secondary structure interactions. Rna (New York, N.Y.). 5: 1665-74. PMID 10606276 DOI: 10.1017/S1355838299991823 |
0.684 |
|
| 1999 |
Silverman SK, Cech TR. RNA tertiary folding monitored by fluorescence of covalently attached pyrene. Biochemistry. 38: 14224-37. PMID 10571996 DOI: 10.1021/Bi991333F |
0.671 |
|
| 1999 |
Hagen M, Cech TR. Self-splicing of the Tetrahymena intron from mRNA in mammalian cells. The Embo Journal. 18: 6491-500. PMID 10562561 DOI: 10.1093/Emboj/18.22.6491 |
0.418 |
|
| 1999 |
Friedman KL, Cech TR. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes & Development. 13: 2863-74. PMID 10557213 DOI: 10.1101/Gad.13.21.2863 |
0.776 |
|
| 1999 |
Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature. 401: 177-80. PMID 10490028 DOI: 10.1038/43694 |
0.826 |
|
| 1999 |
Juneau K, Cech TR. In vitro selection of RNAs with increased tertiary structure stability. Rna (New York, N.Y.). 5: 1119-29. PMID 10445885 DOI: 10.1017/S135583829999074X |
0.837 |
|
| 1999 |
Bryan TM, Cech TR. Telomerase and the maintenance of chromosome ends. Current Opinion in Cell Biology. 11: 318-24. PMID 10395557 DOI: 10.1016/S0955-0674(99)80043-X |
0.711 |
|
| 1999 |
Silverman SK, Cech TR. Energetics and cooperativity of tertiary hydrogen bonds in RNA structure. Biochemistry. 38: 8691-702. PMID 10393544 DOI: 10.1021/Bi9906118 |
0.607 |
|
| 1999 |
Cech TR, Golden BL. 13 Building a Catalytic Active Site Using Only RNA Cold Spring Harbor Monograph Archive. 37: 321-349. DOI: 10.1101/087969589.37.321 |
0.698 |
|
| 1999 |
Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR. erratum: Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle Nature. 402: 898-898. DOI: 10.1038/47284 |
0.695 |
|
| 1998 |
Jabri E, Cech TR. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. Rna (New York, N.Y.). 4: 1481-92. PMID 9848647 DOI: 10.1017/S1355838298981237 |
0.458 |
|
| 1998 |
Golden BL, Gooding AR, Podell ER, Cech TR. A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science (New York, N.Y.). 282: 259-64. PMID 9841391 DOI: 10.1126/Science.282.5387.259 |
0.656 |
|
| 1998 |
Zhang B, Cech TR. Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features. Chemistry & Biology. 5: 539-53. PMID 9818147 DOI: 10.1016/S1074-5521(98)90113-2 |
0.518 |
|
| 1998 |
Nakamura TM, Cooper JP, Cech TR. Two modes of survival of fission yeast without telomerase. Science (New York, N.Y.). 282: 493-6. PMID 9774280 DOI: 10.1126/Science.282.5388.493 |
0.701 |
|
| 1998 |
Cohen SB, Cech TR. A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps. Rna (New York, N.Y.). 4: 1179-85. PMID 9769093 DOI: 10.1017/S1355838298001010 |
0.52 |
|
| 1998 |
Szewczak AA, Podell ER, Bevilacqua PC, Cech TR. Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis. Biochemistry. 37: 11162-70. PMID 9698362 DOI: 10.1021/Bi980633E |
0.596 |
|
| 1998 |
Bryan TM, Sperger JM, Chapman KB, Cech TR. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proceedings of the National Academy of Sciences of the United States of America. 95: 8479-84. PMID 9671703 DOI: 10.1073/Pnas.95.15.8479 |
0.824 |
|
| 1998 |
Lingner J, Cech TR. Telomerase and chromosome end maintenance. Current Opinion in Genetics & Development. 8: 226-32. PMID 9610414 DOI: 10.1016/S0959-437X(98)80145-7 |
0.686 |
|
| 1998 |
Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes & Development. 12: 1504-14. PMID 9585510 DOI: 10.1101/Gad.12.10.1504 |
0.71 |
|
| 1998 |
Bevilacqua PC, George CX, Samuel CE, Cech TR. Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes. Biochemistry. 37: 6303-16. PMID 9572845 DOI: 10.1021/Bi980113J |
0.716 |
|
| 1998 |
Hammond PW, Cech TR. Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation. Biochemistry. 37: 5162-72. PMID 9548747 DOI: 10.1021/Bi972988O |
0.51 |
|
| 1998 |
Nakamura TM, Cech TR. Reversing time: origin of telomerase. Cell. 92: 587-90. PMID 9506510 DOI: 10.1016/S0092-8674(00)81123-X |
0.597 |
|
| 1997 |
Cech TR, Lingner J. Telomerase and the chromosome end replication problem. Ciba Foundation Symposium. 211: 20-8; discussion 28-. PMID 9524749 |
0.73 |
|
| 1997 |
Cech TR, Nakamura TM, Lingner J. Telomerase is a true reverse transcriptase. A review. Biochemistry. Biokhimii͡A. 62: 1202-5. PMID 9467843 |
0.748 |
|
| 1997 |
Chapon C, Cech TR, Zaug AJ. Polyadenylation of telomerase RNA in budding yeast. Rna (New York, N.Y.). 3: 1337-51. PMID 9409624 |
0.442 |
|
| 1997 |
Jabri E, Aigner S, Cech TR. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 36: 16345-54. PMID 9405070 DOI: 10.1021/Bi9718595 |
0.635 |
|
| 1997 |
Zhang B, Cech TR. Peptide bond formation by in vitro selected ribozymes. Nature. 390: 96-100. PMID 9363898 DOI: 10.1038/36375 |
0.409 |
|
| 1997 |
Lingner J, Cech TR, Hughes TR, Lundblad V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proceedings of the National Academy of Sciences of the United States of America. 94: 11190-5. PMID 9326584 DOI: 10.1073/Pnas.94.21.11190 |
0.671 |
|
| 1997 |
Tanner MA, Anderson EM, Gutell RR, Cech TR. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. Rna (New York, N.Y.). 3: 1037-51. PMID 9292502 |
0.589 |
|
| 1997 |
Hammond PW, Cech TR. dGTP-dependent processivity and possible template switching of euplotes telomerase. Nucleic Acids Research. 25: 3698-704. PMID 9278493 DOI: 10.1093/Nar/25.18.3698 |
0.383 |
|
| 1997 |
Szewczak AA, Cech TR. An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. Rna (New York, N.Y.). 3: 838-49. PMID 9257643 |
0.315 |
|
| 1997 |
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science (New York, N.Y.). 277: 955-9. PMID 9252327 DOI: 10.1126/Science.277.5328.955 |
0.717 |
|
| 1997 |
Golden BL, Podell ER, Gooding AR, Cech TR. Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron. Journal of Molecular Biology. 270: 711-23. PMID 9245599 DOI: 10.1006/Jmbi.1997.1155 |
0.649 |
|
| 1997 |
McConnell TS, Herschlag D, Cech TR. Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction. Biochemistry. 36: 8293-303. PMID 9204875 DOI: 10.1021/Bi9700678 |
0.561 |
|
| 1997 |
Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (New York, N.Y.). 276: 561-7. PMID 9110970 DOI: 10.1126/Science.276.5312.561 |
0.726 |
|
| 1997 |
Cooper JP, Nimmo ER, Allshire RC, Cech TR. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature. 385: 744-7. PMID 9034194 DOI: 10.1038/385744A0 |
0.675 |
|
| 1997 |
Tanner MA, Cech TR. Joining the two domains of a group I ribozyme to form the catalytic core. Science (New York, N.Y.). 275: 847-9. PMID 9012355 DOI: 10.1126/Science.275.5301.847 |
0.678 |
|
| 1997 |
Hammond PW, Lively TN, Cech TR. The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers. Molecular and Cellular Biology. 17: 296-308. PMID 8972210 DOI: 10.1128/Mcb.17.1.296 |
0.469 |
|
| 1997 |
Cohen SB, Cech TR. Dynamics of thermal motions within a large catalytic RNA investigated by cross-linking with thiol-disulfide interchange Journal of the American Chemical Society. 119: 6259-6268. DOI: 10.1021/Ja9707421 |
0.388 |
|
| 1996 |
Golden BL, Gooding AR, Podell ER, Cech TR. X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering. Rna (New York, N.Y.). 2: 1295-305. PMID 8972777 |
0.662 |
|
| 1996 |
Rusconi CP, Cech TR. The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena. Genes & Development. 10: 2870-80. PMID 8918888 DOI: 10.1101/Gad.10.22.2870 |
0.383 |
|
| 1996 |
Kuo LY, Cech TR. Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes. Nucleic Acids Research. 24: 3722-7. PMID 8871550 DOI: 10.1093/Nar/24.19.3722 |
0.411 |
|
| 1996 |
Lingner J, Cech TR. Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang. Proceedings of the National Academy of Sciences of the United States of America. 93: 10712-7. PMID 8855245 DOI: 10.1073/Pnas.93.20.10712 |
0.72 |
|
| 1996 |
Tanner MA, Cech TR. Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(Ile) of the purple bacterium Azoarcus Rna. 2: 74-83. PMID 8846298 |
0.552 |
|
| 1996 |
Campbell TB, Cech TR. Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity. Biochemistry. 35: 11493-502. PMID 8784205 DOI: 10.1021/Bi960510Z |
0.368 |
|
| 1996 |
Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna JA. RNA tertiary structure mediation by adenosine platforms. Science (New York, N.Y.). 273: 1696-9. PMID 8781229 DOI: 10.1126/Science.273.5282.1696 |
0.819 |
|
| 1996 |
Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science (New York, N.Y.). 273: 1678-85. PMID 8781224 DOI: 10.1126/Science.273.5282.1678 |
0.804 |
|
| 1996 |
Bevilacqua PC, Cech TR. Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR. Biochemistry. 35: 9983-94. PMID 8756460 DOI: 10.1021/Bi9607259 |
0.703 |
|
| 1996 |
Downs WD, Cech TR. Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks. Rna (New York, N.Y.). 2: 718-32. PMID 8756414 |
0.32 |
|
| 1996 |
Cech TR, Szewczak AA. Selecting apt RNAs for NMR. Rna (New York, N.Y.). 2: 625-7. PMID 8756405 |
0.332 |
|
| 1996 |
Rusconi CP, Cech TR. Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila. The Embo Journal. 15: 3286-95. PMID 8670829 DOI: 10.1002/J.1460-2075.1996.Tb00693.X |
0.333 |
|
| 1996 |
Golden BL, Cech TR. Conformational switches involved in orchestrating the successive steps of group I RNA splicing. Biochemistry. 35: 3754-63. PMID 8619996 DOI: 10.1021/Bi952599Z |
0.652 |
|
| 1996 |
Zaug AJ, Linger J, Cech TR. Method for determining RNA 3' ends and application to human telomerase RNA. Nucleic Acids Research. 24: 532-3. PMID 8602368 DOI: 10.1093/Nar/24.3.532 |
0.452 |
|
| 1996 |
Strobel SA, Cech TR. Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization. Biochemistry. 35: 1201-11. PMID 8573575 DOI: 10.1021/Bi952244F |
0.584 |
|
| 1996 |
Weeks KM, Cech TR. Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science (New York, N.Y.). 271: 345-8. PMID 8553068 DOI: 10.1126/Science.271.5247.345 |
0.718 |
|
| 1996 |
Weinstein LB, Earnshaw DJ, Cosstick R, Cech TR. Synthesis and characterization of an RNA dinucleotide containing a 3'-S-phosphorothiolate linkage Journal of the American Chemical Society. 118: 10341-10350. DOI: 10.1021/Ja9616903 |
0.396 |
|
| 1995 |
Strobel SA, Cech TR. Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science (New York, N.Y.). 267: 675-9. PMID 7839142 DOI: 10.1126/Science.7839142 |
0.655 |
|
| 1995 |
McConnell TS, Cech TR. A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction. Biochemistry. 34: 4056-67. PMID 7696271 DOI: 10.1021/Bi00012A024 |
0.369 |
|
| 1995 |
Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 82: 221-30. PMID 7628013 DOI: 10.1016/0092-8674(95)90309-7 |
0.689 |
|
| 1995 |
Fang G, Cech TR. Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates. The Journal of Cell Biology. 130: 243-53. PMID 7615628 DOI: 10.1083/Jcb.130.2.243 |
0.757 |
|
| 1995 |
Hicke B, Rempel R, Maller J, Swank RA, Hamaguchi JR, Bradbury EM, Prescott DM, Cech TR. Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation. Nucleic Acids Research. 23: 1887-93. PMID 7596814 DOI: 10.1093/Nar/23.11.1887 |
0.311 |
|
| 1995 |
Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR. Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy. The Embo Journal. 14: 4849-59. PMID 7588614 DOI: 10.1002/J.1460-2075.1995.Tb00166.X |
0.612 |
|
| 1995 |
Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem? Science (New York, N.Y.). 269: 1533-4. PMID 7545310 DOI: 10.1126/Science.7545310 |
0.723 |
|
| 1995 |
Cech TR, Damberger SH, Gutell RR. Representation of the secondary and tertiary structure of group I introns. Nature Structural Biology. 1: 273-80. PMID 7545072 DOI: 10.1038/Nsb0594-273 |
0.378 |
|
| 1995 |
Weeks KM, Cech TR. Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron. Biochemistry. 34: 7728-38. PMID 7540041 DOI: 10.1021/Bi00023A020 |
0.617 |
|
| 1995 |
Doudna JA, Cech TR, Sullenger BA. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 92: 2355-9. PMID 7534420 DOI: 10.1073/Pnas.92.6.2355 |
0.57 |
|
| 1995 |
Zaug AJ, Cech TR. Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. Rna (New York, N.Y.). 1: 363-74. PMID 7493315 |
0.428 |
|
| 1995 |
Tanner MA, Cech TR. An important RNA tertiary interaction of group I and group II introns is implicated in gram-positive RNase P RNAs. Rna (New York, N.Y.). 1: 349-50. PMID 7493313 |
0.618 |
|
| 1995 |
Doudna JA, Cech TR. Self-assembly of a group I intron active site from its component tertiary structural domains. Rna (New York, N.Y.). 1: 36-45. PMID 7489486 |
0.465 |
|
| 1995 |
Cech TR. Between the ‘RNA World’ and the ‘Protein World’ Structure. 3: 969-970. DOI: 10.1016/S0969-2126(01)00231-3 |
0.445 |
|
| 1995 |
Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR. Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy. The Embo Journal. 14: 4849-4859. DOI: 10.1002/j.1460-2075.1995.tb00166.x |
0.307 |
|
| 1994 |
Cech TR. The efficiency and versatility of catalytic RNA: implications for an RNA world. Gene. 135: 33-6. PMID 8276275 DOI: 10.1016/0378-1119(93)90046-6 |
0.493 |
|
| 1994 |
Hicke BJ, Willis MC, Koch TH, Cech TR. Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine Biochemistry. 33: 3364-3373. PMID 8136374 DOI: 10.1021/Bi00177A030 |
0.408 |
|
| 1994 |
Murphy FL, Cech TR. GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain. Journal of Molecular Biology. 236: 49-63. PMID 8107125 DOI: 10.1006/Jmbi.1994.1117 |
0.442 |
|
| 1994 |
Murphy FL, Wang YH, Griffith JD, Cech TR. Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme Science. 265: 1709-1712. PMID 8085157 DOI: 10.1126/Science.8085157 |
0.427 |
|
| 1994 |
Cech TR, Uhlenbeck OC. Ribozymes. Hammerhead nailed down. Nature. 372: 39-40. PMID 7969416 DOI: 10.1038/372039A0 |
0.381 |
|
| 1994 |
Lingner J, Hendrick LL, Cech TR. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes & Development. 8: 1984-98. PMID 7958872 DOI: 10.1101/Gad.8.16.1984 |
0.742 |
|
| 1994 |
Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 33: 13856-63. PMID 7947794 DOI: 10.1021/Bi00250A040 |
0.695 |
|
| 1994 |
Sullenger BA, Cech TR. Ribozyme-mediated repair of defective mRNA by targeted trans-splicing Nature. 371: 619-622. PMID 7935797 DOI: 10.1038/371619A0 |
0.457 |
|
| 1994 |
Downs WD, Cech TR. A tertiary interaction in the Tetrahymena intron contributes to selection of the 5' splice site. Genes & Development. 8: 1198-211. PMID 7926724 DOI: 10.1101/Gad.8.10.1198 |
0.436 |
|
| 1994 |
Strobel SA, Cech TR. Translocation of an RNA duplex on a ribozyme. Nature Structural Biology. 1: 13-7. PMID 7544680 DOI: 10.1038/Nsb0194-13 |
0.666 |
|
| 1994 |
Zaug AJ, Dávila-Aponte JA, Cech TR. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNALeu Biochemistry. 33: 14935-14947. PMID 7527660 DOI: 10.1021/Bi00253A033 |
0.485 |
|
| 1994 |
Strobel SA, Cech TR, Usman N, Beigelman L. The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA. Biochemistry. 33: 13824-35. PMID 7524665 DOI: 10.1021/Bi00250A037 |
0.636 |
|
| 1994 |
Wang YH, Murphy FL, Cech TR, Griffith JD. Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy. Journal of Molecular Biology. 236: 64-71. PMID 7508985 DOI: 10.1006/Jmbi.1994.1118 |
0.417 |
|
| 1994 |
Strobel SA, Cech TR, Usman N, Beigelman L. The 2,6-diaminopurine riboside·5-methylisocytidine wobble base pair: An isoenergetic substitution for the study of G·U pairs in RNA Biochemistry. 33: 13824-13835. DOI: 10.1021/bi00250a037 |
0.621 |
|
| 1994 |
Hicke BJ, Willis MC, Koch TH, Cech TR. Telomeric protein-DNA point contacts identified by photo-crosslinking using 5-bromodeoxyuridine. [Erratum to document cited in CA120:186170] Biochemistry. 33: 7744-7744. DOI: 10.1021/Bi00190A031 |
0.32 |
|
| 1994 |
Laggerbauer B, Murphy F, Cech T. Two major tertiary folding transitions of the Tetrahymena catalytic RNA. The Embo Journal. 13: 2669-2676. DOI: 10.1002/J.1460-2075.1994.Tb06557.X |
0.472 |
|
| 1993 |
Fang G, Gray JT, Cech TR. Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit. Genes & Development. 7: 870-82. PMID 8491383 DOI: 10.1101/Gad.7.5.870 |
0.676 |
|
| 1993 |
Piccirilli JA, Vyle JS, Caruthers MH, Cech TR. Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature. 361: 85-8. PMID 8421499 DOI: 10.1038/361085A0 |
0.611 |
|
| 1993 |
McConnell TS, Cech TR, Herschlag D. Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding. Proceedings of the National Academy of Sciences of the United States of America. 90: 8362-6. PMID 8378306 DOI: 10.1073/Pnas.90.18.8362 |
0.555 |
|
| 1993 |
Fang G, Cech TR. The β subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA Cell. 74: 875-885. PMID 8374954 DOI: 10.1016/0092-8674(93)90467-5 |
0.711 |
|
| 1993 |
Cech TR. Catalytic RNA: structure and mechanism. Biochemical Society Transactions. 21: 229-34. PMID 8359471 DOI: 10.1042/Bst0210229 |
0.412 |
|
| 1993 |
Zaug AJ, McEvoy MM, Cech TR. Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem. Biochemistry. 32: 7946-53. PMID 8347600 DOI: 10.1021/Bi00082A016 |
0.391 |
|
| 1993 |
Fang G, Cech TR. Oxytricha telomere-binding protein: DNA-dependent dimerization of the α and β subunits Proceedings of the National Academy of Sciences of the United States of America. 90: 6056-6060. PMID 8327484 DOI: 10.1073/Pnas.90.13.6056 |
0.69 |
|
| 1993 |
Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR. Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Molecular and Cellular Biology. 13: 4301-10. PMID 8321232 DOI: 10.1128/Mcb.13.7.4301 |
0.594 |
|
| 1993 |
Sullenger BA, Cech TR. Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science (New York, N.Y.). 262: 1566-9. PMID 8248806 DOI: 10.1126/Science.8248806 |
0.487 |
|
| 1993 |
Willis MC, Hicke BJ, Uhlenbeck OC, Cech TR, Koch TH. Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins Science. 262: 1255-1257. PMID 7694369 DOI: 10.1126/Science.7694369 |
0.468 |
|
| 1993 |
Cech TR. RNA. Fishing for fresh catalysts. Nature. 365: 204-5. PMID 7690464 DOI: 10.1038/365204A0 |
0.39 |
|
| 1993 |
Herschlag D, Eckstein F, Cech TR. The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction. Biochemistry. 32: 8312-21. PMID 7688573 DOI: 10.1021/Bi00083A035 |
0.547 |
|
| 1993 |
Herschlag D, Eckstein F, Cech TR. Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA. Biochemistry. 32: 8299-311. PMID 7688572 DOI: 10.1021/Bi00083A034 |
0.659 |
|
| 1993 |
Murphy FL, Cech TR. An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme. Biochemistry. 32: 5291-300. PMID 7684607 DOI: 10.1021/Bi00071A003 |
0.507 |
|
| 1993 |
Wang JF, Downs WD, Cech TR. Movement of the guide sequence during RNA catalysis by a group I ribozyme. Science (New York, N.Y.). 260: 504-8. PMID 7682726 DOI: 10.1126/Science.7682726 |
0.523 |
|
| 1993 |
Strobel SA, Cech TR. Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme. Biochemistry. 32: 13593-604. PMID 7504953 DOI: 10.1021/Bi00212A027 |
0.613 |
|
| 1992 |
Piccirilli JA, McConnell TS, Zaug AJ, Noller HF, Cech TR. Aminoacyl esterase activity of the Tetrahymena ribozyme. Science (New York, N.Y.). 256: 1420-4. PMID 1604316 DOI: 10.1126/Science.1604316 |
0.684 |
|
| 1992 |
Legault P, Herschlag D, Celander DW, Cech TR. Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis. Nucleic Acids Research. 20: 6613-9. PMID 1480482 DOI: 10.1093/Nar/20.24.6613 |
0.582 |
|
| 1992 |
Cech TR, Herschlag D, Piccirilli JA, Pyle AM. RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. The Journal of Biological Chemistry. 267: 17479-82. PMID 1381347 |
0.744 |
|
| 1992 |
Pyle AM, Murphy FL, Cech TR. RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme. Nature. 358: 123-8. PMID 1377367 DOI: 10.1038/358123A0 |
0.67 |
|
| 1992 |
Wang JF, Cech TR. Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme. Science (New York, N.Y.). 256: 526-9. PMID 1315076 DOI: 10.1126/Science.1315076 |
0.494 |
|
| 1991 |
Herschlag D, Piccirilli JA, Cech TR. Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom. Biochemistry. 30: 4844-54. PMID 2036355 DOI: 10.1021/Bi00234A003 |
0.668 |
|
| 1991 |
Zahler AM, Williamson JR, Cech TR, Prescott DM. Inhibition of telomerase by G-quartet DNA structures. Nature. 350: 718-20. PMID 2023635 DOI: 10.1038/350718A0 |
0.609 |
|
| 1991 |
Woodson SA, Cech TR. Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA. Biochemistry. 30: 2042-50. PMID 1998665 DOI: 10.1021/Bi00222A006 |
0.661 |
|
| 1991 |
Cech TR. RNA editing: world's smallest introns? Cell. 64: 667-9. PMID 1997201 DOI: 10.1016/0092-8674(91)90494-J |
0.461 |
|
| 1991 |
Celander DW, Cech TR. Visualizing the higher order folding of a catalytic RNA molecule. Science (New York, N.Y.). 251: 401-7. PMID 1989074 DOI: 10.1126/Science.1989074 |
0.474 |
|
| 1991 |
Young B, Herschlag D, Cech TR. Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity. Cell. 67: 1007-19. PMID 1959129 DOI: 10.1016/0092-8674(91)90373-7 |
0.669 |
|
| 1991 |
Fang G, Cech TR. Molecular cloning of telomere-binding protein gens from Stylonchia mytilis Nucleic Acids Research. 19: 5515-5518. PMID 1945829 DOI: 10.1093/Nar/19.20.5515 |
0.686 |
|
| 1991 |
Gampel A, Cech TR. Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA. Genes & Development. 5: 1870-80. PMID 1916266 DOI: 10.1101/Gad.5.10.1870 |
0.539 |
|
| 1991 |
Davila-Aponte JA, Huss VAR, Sogin ML, Cech TR. A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus Nucleic Acids Research. 19: 4429-4436. PMID 1886767 DOI: 10.1093/Nar/19.16.4429 |
0.501 |
|
| 1991 |
Gray JT, Celander DW, Price CM, Cech TR. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell. 67: 807-14. PMID 1840510 DOI: 10.1016/0092-8674(91)90075-A |
0.68 |
|
| 1991 |
Heuer TS, Chandry PS, Belfort M, Celander DW, Cech TR. Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core. Proceedings of the National Academy of Sciences of the United States of America. 88: 11105-9. PMID 1763026 DOI: 10.1073/Pnas.88.24.11105 |
0.447 |
|
| 1991 |
Pyle AM, Cech TR. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups. Nature. 350: 628-31. PMID 1708111 DOI: 10.1038/350628A0 |
0.697 |
|
| 1991 |
Grosshans CA, Cech TR. A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification. Nucleic Acids Research. 19: 3875-80. PMID 1650453 DOI: 10.1093/Nar/19.14.3875 |
0.406 |
|
| 1990 |
Woodson SA, Cech TR, Young M, Perriman R, Kelly L, Graf L, Llewellyn D, Gerlach W, Plückthun A, Collins J. Symposium 3: Non-enzymatic biocatalysts in nature and biotechnology. Fresenius' Journal of Analytical Chemistry. 337: 12-14. PMID 32226232 DOI: 10.1007/Bf00325711 |
0.487 |
|
| 1990 |
Grosshans CA, Cech TR. Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme. Biochemistry. 28: 6888-94. PMID 2684268 DOI: 10.1021/Bi00443A017 |
0.353 |
|
| 1990 |
Young B, Cech TR. Specificity for 3',5'-linked substrates in RNA-catalyzed RNA polymerization. Journal of Molecular Evolution. 29: 480-5. PMID 2482370 DOI: 10.1007/Bf02602919 |
0.499 |
|
| 1990 |
Murphy FL, Cech TR. Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme. Proceedings of the National Academy of Sciences of the United States of America. 86: 9218-22. PMID 2480597 DOI: 10.1073/Pnas.86.23.9218 |
0.5 |
|
| 1990 |
Raghuraman MK, Cech TR. Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein. Nucleic Acids Research. 18: 4543-52. PMID 2388834 DOI: 10.1093/Nar/18.15.4543 |
0.74 |
|
| 1990 |
Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site. Biochemistry. 29: 10172-80. PMID 2271646 DOI: 10.1021/Bi00496A004 |
0.582 |
|
| 1990 |
Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry. 29: 10159-71. PMID 2271645 DOI: 10.1021/Bi00496A003 |
0.609 |
|
| 1990 |
Pyle AM, McSwiggen JA, Cech TR. Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America. 87: 8187-91. PMID 2236030 DOI: 10.1073/Pnas.87.21.8187 |
0.64 |
|
| 1990 |
Downs WD, Cech TR. An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme. Biochemistry. 29: 5605-13. PMID 2201409 DOI: 10.1021/Bi00475A027 |
0.41 |
|
| 1990 |
Latham JA, Zaug AJ, Cech TR. Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence Methods in Enzymology. 181: 558-569. PMID 2199766 DOI: 10.1016/0076-6879(90)81151-J |
0.466 |
|
| 1990 |
Cech TR. Self-splicing of group I introns. Annual Review of Biochemistry. 59: 543-68. PMID 2197983 DOI: 10.1146/Annurev.Bi.59.070190.002551 |
0.358 |
|
| 1990 |
Celander DW, Cech TR. Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms. Biochemistry. 29: 1355-61. PMID 2110477 DOI: 10.1021/Bi00458A001 |
0.457 |
|
| 1990 |
Cech TR. Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Bioscience Reports. 10: 239-261. PMID 1699616 DOI: 10.1007/Bf01117241 |
0.497 |
|
| 1990 |
Herschlag D, Cech TR. DNA cleavage catalysed by the ribozyme from Tetrahymena. Nature. 344: 405-9. PMID 1690858 DOI: 10.1038/344405A0 |
0.678 |
|
| 1990 |
Hicke BJ, Celander DW, MacDonald GH, Price CM, Cech TR. Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proceedings of the National Academy of Sciences of the United States of America. 87: 1481-5. PMID 1689486 DOI: 10.1073/Pnas.87.4.1481 |
0.664 |
|
| 1990 |
Herschlag D, Cech TR. Erratum: DNA cleavage catalysed by the ribozyme from Tetrahymena Nature. 344: 792-792. DOI: 10.1038/344792B0 |
0.568 |
|
| 1990 |
Woodson SA, Cech TR, Young M, Perriman R, Kelly L, Graf L, Llewellyn D, Gerlach W, Plückthun A, Collins J. Symposium 3: Non-enzymatic biocatalysts in nature and biotechnology Fresenius' Journal of Analytical Chemistry. 337: 12-14. DOI: 10.1007/BF00325711 |
0.425 |
|
| 1990 |
Cech TR. Self‐splicing and Enzymatic Activity of an Intervening Sequence RNA from Tetrahymena (Nobel Lecture) Angewandte Chemie. 29: 759-768. DOI: 10.1002/Anie.199007591 |
0.476 |
|
| 1990 |
Cech TR. Selbstspleißen und enzymatische Aktivität einer intervenierenden Sequenz der RNA vonTetrahymena (Nobel-Vortrag) Angewandte Chemie. 102: 745-755. DOI: 10.1002/Ange.19901020705 |
0.478 |
|
| 1989 |
Cech TR. Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review. Gene. 73: 259-71. PMID 3072259 DOI: 10.1016/0378-1119(88)90492-1 |
0.468 |
|
| 1989 |
Zaug AJ, Grosshans CA, Cech TR. Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes. Biochemistry. 27: 8924-31. PMID 3069131 DOI: 10.1021/Bi00425A008 |
0.45 |
|
| 1989 |
Barfod ET, Cech TR. The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing. Molecular and Cellular Biology. 9: 3657-66. PMID 2779562 DOI: 10.1128/Mcb.9.9.3657 |
0.349 |
|
| 1989 |
Price CM, Cech TR. Properties of the telomeric DNA-binding protein from Oxytricha nova. Biochemistry. 28: 769-74. PMID 2713343 DOI: 10.1021/Bi00428A053 |
0.662 |
|
| 1989 |
Woodson SA, Cech TR. Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition. Cell. 57: 335-45. PMID 2702692 DOI: 10.1016/0092-8674(89)90971-9 |
0.653 |
|
| 1989 |
Yarus M, Levine J, Morin GB, Cech TR. A Tetrahymena intron nucleotide connected to the GTP/arginine site Nucleic Acids Research. 17: 6969-6981. PMID 2674904 DOI: 10.1093/Nar/17.17.6969 |
0.489 |
|
| 1989 |
Cech TR. RNA chemistry. Ribozyme self-replication? Nature. 339: 507-8. PMID 2660002 DOI: 10.1038/339507A0 |
0.44 |
|
| 1989 |
Williamson JR, Raghuraman MK, Cech TR. Monovalent cation-induced structure of telomeric DNA: the G-quartet model. Cell. 59: 871-80. PMID 2590943 DOI: 10.1016/0092-8674(89)90610-7 |
0.753 |
|
| 1989 |
Raghuraman MK, Cech TR. Assembly and self-association of oxytricha telomeric nucleoprotein complexes. Cell. 59: 719-28. PMID 2582492 DOI: 10.1016/0092-8674(89)90018-4 |
0.73 |
|
| 1989 |
Latham JA, Cech TR. Defining the inside and outside of a catalytic RNA molecule Science. 245: 276-282. PMID 2501870 DOI: 10.1126/Science.2501870 |
0.503 |
|
| 1989 |
Raghuraman MK, Dunn CJ, Hicke BJ, Cech TR. Oxytricha telomeric nucleoprotein complexes reconstituted with synthetic DNA. Nucleic Acids Research. 17: 4235-53. PMID 2500641 DOI: 10.1093/Nar/17.11.4235 |
0.738 |
|
| 1989 |
McSwiggen JA, Cech TR. Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting. Science (New York, N.Y.). 244: 679-83. PMID 2470150 DOI: 10.1126/Science.2470150 |
0.488 |
|
| 1989 |
Flor P, Flanegan J, Cech T. A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing. The Embo Journal. 8: 3391-3399. DOI: 10.1002/J.1460-2075.1989.Tb08503.X |
0.415 |
|
| 1988 |
Kim SH, Cech TR. Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America. 84: 8788-92. PMID 3480510 DOI: 10.1073/Pnas.84.24.8788 |
0.454 |
|
| 1988 |
Barfod ET, Cech TR. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity. Genes & Development. 2: 652-63. PMID 3417146 DOI: 10.1101/Gad.2.6.652 |
0.419 |
|
| 1988 |
Zaug AJ, Cech TR. Self-splicing RNA and an RNA enzyme in Tetrahymena. The Journal of Protozoology. 34: 416-7. PMID 3323479 DOI: 10.1111/J.1550-7408.1987.Tb03204.X |
0.508 |
|
| 1988 |
Price JV, Cech TR. Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA Genes &Amp; Development. 2: 1439-1447. PMID 3209068 DOI: 10.1101/Gad.2.11.1439 |
0.39 |
|
| 1988 |
Morin GB, Cech TR. Telomeric repeats of Tetrahymena malaccensis mitochondrial DNA: a multimodal distribution that fluctuates erratically during growth. Molecular and Cellular Biology. 8: 4450-8. PMID 3185556 DOI: 10.1128/Mcb.8.10.4450 |
0.316 |
|
| 1988 |
Morin GB, Cech TR. Mitochondrial telomeres: surprising diversity of repeated telomeric DNA sequences among six species of Tetrahymena. Cell. 52: 367-74. PMID 3125982 DOI: 10.1016/S0092-8674(88)80029-1 |
0.377 |
|
| 1988 |
Morin GB, Cech TR. Phylogenetic relationships and altered genome structures among Tetrahymena mitochondrial DNAs. Nucleic Acids Research. 16: 327-46. PMID 2829120 DOI: 10.1093/Nar/16.1.327 |
0.365 |
|
| 1988 |
Been MD, Cech TR. RNA as an RNA polymerase: Net elongation of an RNA primer catalyzed by the tetrahymena ribozyme Science. 239: 1412-1416. PMID 2450400 DOI: 10.1126/Science.2450400 |
0.506 |
|
| 1988 |
Cech TR. Ribozymes and Their Medical Implications Jama: the Journal of the American Medical Association. 260: 3030. DOI: 10.1001/Jama.1988.03410200086031 |
0.497 |
|
| 1987 |
Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF. Structural conventions for group I introns Nucleic Acids Research. 15: 7217-7221. PMID 3658691 DOI: 10.1093/Nar/15.18.7217 |
0.494 |
|
| 1987 |
Been MD, Barfod ET, Burke JM, Price JV, Tanner NK, Zaug AJ, Cech TR. Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity Cold Spring Harbor Symposia On Quantitative Biology. 52: 147-157. PMID 3454258 DOI: 10.1101/Sqb.1987.052.01.019 |
0.443 |
|
| 1987 |
Price CM, Cech TR. Telomeric DNA-protein interactions of Oxytricha macronuclear DNA. Genes & Development. 1: 783-93. PMID 3123321 DOI: 10.1101/Gad.1.8.783 |
0.666 |
|
| 1987 |
Price JV, Engberg J, Cech TR. 5′ exon requirement for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA and identification of a cryptic 5′ splice site in the 3′ exon Journal of Molecular Biology. 196: 49-60. PMID 2443717 DOI: 10.1016/0022-2836(87)90510-9 |
0.496 |
|
| 1987 |
Been MD, Cech TR. Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence Cell. 50: 951-961. PMID 2441876 DOI: 10.1016/0092-8674(87)90522-8 |
0.394 |
|
| 1987 |
Cech TR. The chemistry of self-splicing RNA and RNA enzymes. Science (New York, N.Y.). 236: 1532-9. PMID 2438771 DOI: 10.1126/Science.2438771 |
0.5 |
|
| 1987 |
Inoue T, Sullivan FX, Cech TR. New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing. Journal of Molecular Biology. 189: 143-65. PMID 2431151 DOI: 10.1016/0022-2836(86)90387-6 |
0.411 |
|
| 1987 |
Cech T. RNA world Nature. 328: 676-676. DOI: 10.1038/328676b0 |
0.369 |
|
| 1987 |
Zaug AJ, Been MD, Cech TR. Erratum: The Tetrahymena ribozyme acts like an RNA restriction endonuclease Nature. 325: 646-646. DOI: 10.1038/325646A0 |
0.515 |
|
| 1987 |
CECH TR. ChemInform Abstract: The Chemistry of Self-Splicing RNA and RNA Enzymes Cheminform. 18. DOI: 10.1002/CHIN.198744394 |
0.364 |
|
| 1986 |
Zaug AJ, Kent JR, Cech TR. Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis. Biochemistry. 24: 6211-8. PMID 4084515 DOI: 10.1021/Bi00343A027 |
0.479 |
|
| 1986 |
Zaug AJ, Cech TR. The intervening sequence RNA of Tetrahymena is an enzyme. Science (New York, N.Y.). 231: 470-5. PMID 3941911 DOI: 10.1126/Science.3941911 |
0.479 |
|
| 1986 |
Inoue T, Sullivan FX, Cech TR. Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exons. Cell. 43: 431-7. PMID 3865712 DOI: 10.1016/0092-8674(85)90173-4 |
0.454 |
|
| 1986 |
Bass BL, Cech TR. Ribozyme inhibitors: Deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the tetrahymena ribosomal ribonucleic acid precursor Biochemistry®. 25: 4473-4477. PMID 3639741 DOI: 10.1021/Bi00364A001 |
0.659 |
|
| 1986 |
Garriga G, Lambowitz AM, Inoue T, Cech TR. Mechanism of recognition of the 5' splice site in self-splicing group I introns. Nature. 322: 86-9. PMID 3636598 DOI: 10.1038/322086A0 |
0.492 |
|
| 1986 |
Zaug AJ, Been MD, Cech TR. The Tetrahymena ribozyme acts like an RNA restriction endonuclease Nature. 324: 429-433. PMID 3537808 DOI: 10.1038/324429A0 |
0.507 |
|
| 1986 |
Been MD, Cech TR. One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity Cell. 47: 207-216. PMID 3021333 DOI: 10.1016/0092-8674(86)90443-5 |
0.467 |
|
| 1986 |
Morin GB, Cech TR. The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats. Cell. 46: 873-83. PMID 3019555 DOI: 10.1016/0092-8674(86)90069-3 |
0.38 |
|
| 1986 |
Cech TR. RNA as an enzyme. Scientific American. 255: 64-75. PMID 2430331 DOI: 10.1038/Scientificamerican1186-64 |
0.446 |
|
| 1986 |
Zaug AJ, Cech TR. The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase. Biochemistry. 25: 4478-82. PMID 2429688 DOI: 10.1021/Bi00364A002 |
0.347 |
|
| 1986 |
Cech TR, Bass BL. Biological catalysis by RNA Annual Review of Biochemistry. 55: 599-629. PMID 2427016 DOI: 10.1146/Annurev.Bi.55.070186.003123 |
0.683 |
|
| 1986 |
Cech TR. A model for the RNA-catalyzed replication of RNA. Proceedings of the National Academy of Sciences of the United States of America. 83: 4360-3. PMID 2424025 DOI: 10.1073/Pnas.83.12.4360 |
0.515 |
|
| 1986 |
Burke JM, Irvine KD, Kaneko KJ, Kerker BJ, Oettgen AB, Tierney WM, Williamson CL, Zaug AJ, Cech TR. Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor Cell. 45: 167-176. PMID 2421916 DOI: 10.1016/0092-8674(86)90380-6 |
0.429 |
|
| 1986 |
Cech TR. The generality of self-splicing RNA: relationship to nuclear mRNA splicing. Cell. 44: 207-10. PMID 2417724 DOI: 10.1016/0092-8674(86)90751-8 |
0.429 |
|
| 1985 |
Been MD, Cech TR. Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure Nucleic Acids Research. 13: 8389-8408. PMID 4080546 DOI: 10.1093/Nar/13.23.8389 |
0.386 |
|
| 1985 |
Price JV, Kieft GL, Kent JR, Sievers EL, Cech TR. Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA Nucleic Acids Research. 13: 1871-1889. PMID 4000946 DOI: 10.1093/Nar/13.6.1871 |
0.454 |
|
| 1985 |
Cech TR. Self-splicing RNA: implications for evolution. International Review of Cytology. 93: 3-22. PMID 3891660 DOI: 10.1016/S0074-7696(08)61370-4 |
0.438 |
|
| 1985 |
Sullivan FX, Cech TR. Reversibility of cyclization of the Tetrahymena rRNA intervening sequence: implication for the mechanism of splice site choice. Cell. 42: 639-48. PMID 3849344 DOI: 10.1016/0092-8674(85)90121-7 |
0.454 |
|
| 1985 |
Price JV, Cech TR. Coupling of Tetrahymena ribosomal RNA splicing to β-galactosidase expression in Escherichia coli Science. 228: 719-722. PMID 2986286 DOI: 10.1126/Science.2986286 |
0.492 |
|
| 1985 |
Inoue T, Cech TR. Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America. 82: 648-52. PMID 2579378 DOI: 10.1073/Pnas.82.3.648 |
0.521 |
|
| 1985 |
Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites. Nucleic Acids Research. 13: 7759-79. PMID 2415924 DOI: 10.1093/Nar/13.21.7759 |
0.517 |
|
| 1985 |
Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes. Nucleic Acids Research. 13: 7741-58. PMID 2415923 DOI: 10.1093/Nar/13.21.7741 |
0.446 |
|
| 1985 |
Zaug AJ, Cech TR. Oligomerization of intervening sequence RNA molecules in the absence of proteins. Science (New York, N.Y.). 229: 1060-4. PMID 2412290 DOI: 10.1126/Science.2412290 |
0.519 |
|
| 1984 |
Bass BL, Cech TR. Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: Implications for biological catalysis by RNA Nature. 308: 820-826. PMID 6562377 DOI: 10.1038/308820A0 |
0.688 |
|
| 1984 |
Gottschling DE, Cech TR. Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex. Cell. 38: 501-10. PMID 6432344 DOI: 10.1016/0092-8674(84)90505-1 |
0.678 |
|
| 1984 |
Palen TE, Cech TR. Chromatin structure at the replication origins and transcription-initiation regions of the ribosomal RNA genes of Tetrahymena. Cell. 36: 933-42. PMID 6323028 DOI: 10.1016/0092-8674(84)90043-6 |
0.409 |
|
| 1984 |
Pardue ML, Fostel JM, Cech TR. DNA-protein interactions in the Drosophila virilis mitochondrial chromosome. Nucleic Acids Research. 12: 1991-9. PMID 6322130 DOI: 10.1093/Nar/12.4.1991 |
0.639 |
|
| 1984 |
Zaug AJ, Kent JR, Cech TR. A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA. Science (New York, N.Y.). 224: 574-8. PMID 6200938 DOI: 10.1126/Science.6200938 |
0.508 |
|
| 1983 |
Brehm SL, Cech TR. Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo. Biochemistry. 22: 2390-7. PMID 6860634 DOI: 10.1021/Bi00279A014 |
0.522 |
|
| 1983 |
Gottschling DE, Palen TE, Cech TR. Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila. Nucleic Acids Research. 11: 2093-109. PMID 6835846 DOI: 10.1093/Nar/11.7.2093 |
0.722 |
|
| 1983 |
Cech TR. RNA splicing: three themes with variations. Cell. 34: 713-6. PMID 6354470 DOI: 10.1016/0092-8674(83)90527-5 |
0.513 |
|
| 1983 |
Cech TR, Tanner NK, Tinoco I, Weir BR, Zuker M, Perlman PS. Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences. Proceedings of the National Academy of Sciences of the United States of America. 80: 3903-7. PMID 6306649 DOI: 10.1073/Pnas.80.13.3903 |
0.459 |
|
| 1983 |
Palen TE, Cech TR. Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease. Nucleic Acids Research. 11: 2077-91. PMID 6300792 DOI: 10.1093/Nar/11.7.2077 |
0.389 |
|
| 1983 |
Zaug AJ, Grabowski PJ, Cech TR. Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage-ligation reaction. Nature. 301: 578-83. PMID 6186917 DOI: 10.1038/301578A0 |
0.511 |
|
| 1982 |
Zaug AJ, Cech TR. The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA. Nucleic Acids Research. 10: 2823-38. PMID 7099968 DOI: 10.1093/Nar/10.9.2823 |
0.537 |
|
| 1982 |
Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 31: 147-57. PMID 6297745 DOI: 10.1016/0092-8674(82)90414-7 |
0.757 |
|
| 1981 |
Cech TR, Brehm SL. Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia. Nucleic Acids Research. 9: 3531-43. PMID 7279667 DOI: 10.1093/Nar/9.14.3531 |
0.465 |
|
| 1981 |
Cech TR. Alkaline gel electrophoresis of deoxyribonucleic acid photoreacted with trimethylpsoralen: rapid and sensitive detection of interstrand cross-links. Biochemistry. 20: 1431-7. PMID 6261794 DOI: 10.1021/Bi00509A005 |
0.344 |
|
| 1981 |
Grabowski PJ, Zaug AJ, Cech TR. The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena. Cell. 23: 467-76. PMID 6162571 DOI: 10.1016/0092-8674(81)90142-2 |
0.507 |
|
| 1981 |
Cech TR, Zaug AJ, Grabowski PJ. In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell. 27: 487-96. PMID 6101203 DOI: 10.1016/0092-8674(81)90390-1 |
0.514 |
|
| 1980 |
Cech TR, Karrer KM. Chromatin structure of the ribosomal RNA genes of Tetrahymena thermophila as analyzed by trimethylpsoralen crosslinking in vivo Journal of Molecular Biology. 136: 395-416. PMID 7365791 DOI: 10.1016/0022-2836(80)90397-6 |
0.431 |
|
| 1980 |
Zaug AJ, Cech TR. In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena. Cell. 19: 331-8. PMID 7357611 DOI: 10.1016/0092-8674(80)90507-3 |
0.495 |
|
| 1980 |
Potter DA, Fostel JM, Berninger M, Pardue ML, Cech TR. DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns. Proceedings of the National Academy of Sciences of the United States of America. 77: 4118-22. PMID 6776522 DOI: 10.1073/Pnas.77.7.4118 |
0.624 |
|
| 1979 |
Cech TR, Rio DC. Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping Proceedings of the National Academy of Sciences of the United States of America. 76: 5051-5055. PMID 291921 DOI: 10.1073/Pnas.76.10.5051 |
0.468 |
|
| 1978 |
Cech TR, Potter D, Pardue ML. Chromatin structure in living cells. Cold Spring Harbor Symposia On Quantitative Biology. 42: 191-8. PMID 277339 DOI: 10.1101/Sqb.1978.042.01.021 |
0.56 |
|
| 1977 |
Cech T, Potter D, Pardue ML. Electron microscopy of DNA cross-linked with trimethylpsoralen: a probe for chromatin structure. Biochemistry. 16: 5313-21. PMID 921934 DOI: 10.1021/Bi00643A024 |
0.591 |
|
| 1977 |
Cech T, Pardue ML. Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure. Cell. 11: 631-40. PMID 560256 DOI: 10.1016/0092-8674(77)90080-0 |
0.628 |
|
| 1976 |
Cech TR, Pardue ML. Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences. Proceedings of the National Academy of Sciences of the United States of America. 73: 2644-8. PMID 1066674 DOI: 10.1073/Pnas.73.8.2644 |
0.623 |
|
| 1976 |
Wiesehahn G, Cech TR, Hearst JE. A study of DNA denaturation in the ultracentrifuge. Biopolymers. 15: 1591-613. PMID 822895 DOI: 10.1002/Bip.1976.360150813 |
0.55 |
|
| 1976 |
Cech TR, Hearst JE. Organization of highly repeated sequences in mouse main-band DNA. Journal of Molecular Biology. 100: 227-56. PMID 768484 DOI: 10.1016/S0022-2836(76)80061-7 |
0.578 |
|
| 1976 |
Cech TR, Reisler F, Hearst JE. Partial denaturation of mouse DNA in preparative CsCl density gradients at alkaline pH. Biochemistry. 15: 1865-73. PMID 5117 DOI: 10.1021/bi00654a012 |
0.483 |
|
| 1975 |
Cech TR, Hearst JE. An electron microscopic study of mouse foldback DNA. Cell. 5: 429-46. PMID 1157097 DOI: 10.1016/0092-8674(75)90062-8 |
0.591 |
|
| 1974 |
Hearst JE, Cech TR, Marx KA, Rosenfeld A, Allen JR. Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA. Cold Spring Harbor Symposia On Quantitative Biology. 38: 329-39. PMID 4208786 DOI: 10.1101/Sqb.1974.038.01.036 |
0.545 |
|
| 1973 |
Cech TR, Rosenfeld A, Hearst JE. Characterization of the most rapidly renaturing sequences in mouse main-band DNA. Journal of Molecular Biology. 81: 299-325. PMID 4767458 DOI: 10.1016/0022-2836(73)90143-5 |
0.573 |
|
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