| Year |
Citation |
Score |
| 2019 |
Rogala KB, Gu X, Kedir JF, Abu-Remaileh M, Bianchi LF, Bottino AMS, Dueholm R, Niehaus A, Overwijn D, Fils AP, Zhou SX, Leary D, Laqtom NN, Brignole EJ, Sabatini DM. Structural basis for the docking of mTORC1 on the lysosomal surface. Science (New York, N.Y.). PMID 31601708 DOI: 10.1126/Science.Aay0166 |
0.385 |
|
| 2018 |
Chen PY, Funk MA, Brignole EJ, Drennan CL. Disruption of an oligomeric interface prevents allosteric inhibition of class Ia ribonucleotide reductase. The Journal of Biological Chemistry. PMID 29700111 DOI: 10.1074/Jbc.Ra118.002569 |
0.359 |
|
| 2018 |
Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature. PMID 29590090 DOI: 10.1038/Nature26158 |
0.408 |
|
| 2018 |
Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife. 7. PMID 29460780 DOI: 10.7554/Elife.31502 |
0.371 |
|
| 2017 |
Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP. Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 28634302 DOI: 10.1073/Pnas.1702849114 |
0.373 |
|
| 2016 |
Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL. Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry. PMID 26727048 DOI: 10.1021/Acs.Biochem.5B01207 |
0.329 |
|
| 2015 |
Mattaini KR, Brignole EJ, Kini M, Davidson SM, Fiske BP, Drennan CL, Vander Heiden MG. An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation. Cancer & Metabolism. 3: 5. PMID 25926973 DOI: 10.1186/S40170-015-0131-7 |
0.374 |
|
| 2013 |
Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J. Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 110: 3835-40. PMID 23431160 DOI: 10.1073/Pnas.1220691110 |
0.364 |
|
| 2012 |
Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chemistry & Biology. 19: 799-805. PMID 22840768 DOI: 10.1016/J.Chembiol.2012.05.015 |
0.337 |
|
| 2012 |
Brignole EJ, Ando N, Zimanyi CM, Drennan CL. The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years. Biochemical Society Transactions. 40: 523-30. PMID 22616862 DOI: 10.1042/Bst20120081 |
0.356 |
|
| 2012 |
Gibbons BJ, Brignole EJ, Azubel M, Murakami K, Voss NR, Bushnell DA, Asturias FJ, Kornberg RD. Subunit architecture of general transcription factor TFIIH. Proceedings of the National Academy of Sciences of the United States of America. 109: 1949-54. PMID 22308316 DOI: 10.1073/Pnas.1105266109 |
0.381 |
|
| 2011 |
Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL. Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 108: 21046-51. PMID 22160671 DOI: 10.1073/Pnas.1112715108 |
0.347 |
|
| 2011 |
Fernandes SM, Brignole EJ, Taori K, Gibson W. Cytomegalovirus capsid protease: biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin). Journal of Virology. 85: 3526-34. PMID 21270147 DOI: 10.1128/Jvi.02663-10 |
0.612 |
|
| 2009 |
Brignole EJ, Smith S, Asturias FJ. Conformational flexibility of metazoan fatty acid synthase enables catalysis. Nature Structural & Molecular Biology. 16: 190-7. PMID 19151726 DOI: 10.1038/Nsmb.1532 |
0.339 |
|
| 2007 |
Brignole EJ, Gibson W. Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain. Journal of Virology. 81: 4091-103. PMID 17287260 DOI: 10.1128/Jvi.02821-06 |
0.614 |
|
| 2007 |
Loveland AN, Nguyen NL, Brignole EJ, Gibson W. The amino-conserved domain of human cytomegalovirus UL80a proteins is required for key interactions during early stages of capsid formation and virus production. Journal of Virology. 81: 620-8. PMID 17079329 DOI: 10.1128/Jvi.01903-06 |
0.607 |
|
| 2007 |
Brignole EJ, Gibson W. Erratum: Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: Maximal activity of pPR requires self-interaction through its scaffolding domain (Journal of Virology (2007) 81, 8 (4091-4103)) Journal of Virology. 81. DOI: 10.1128/Jvi.00678-07 |
0.559 |
|
| 2005 |
Loveland AN, Chan CK, Brignole EJ, Gibson W. Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity. Journal of Virology. 79: 12961-8. PMID 16188998 DOI: 10.1128/Jvi.79.20.12961-12968.2005 |
0.577 |
|
| 2005 |
McCartney SA, Brignole EJ, Kolegraff KN, Loveland AN, Ussin LM, Gibson W. Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a. The Journal of Biological Chemistry. 280: 33206-12. PMID 16036911 DOI: 10.1074/Jbc.M506876200 |
0.611 |
|
| 2004 |
Casaday RJ, Bailey JR, Kalb SR, Brignole EJ, Loveland AN, Cotter RJ, Gibson W. Assembly protein precursor (pUL80.5 homolog) of simian cytomegalovirus is phosphorylated at a glycogen synthase kinase 3 site and its downstream "priming" site: phosphorylation affects interactions of protein with itself and with major capsid protein. Journal of Virology. 78: 13501-11. PMID 15564461 DOI: 10.1128/Jvi.78.24.13501-13511.2004 |
0.505 |
|
| 2002 |
Chan CK, Brignole EJ, Gibson W. Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions. Journal of Virology. 76: 8667-74. PMID 12163586 DOI: 10.1128/Jvi.76.17.8667-8674.2002 |
0.598 |
|
| 1998 |
Ahn JH, Brignole EJ, Hayward GS. Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML Molecular and Cellular Biology. 18: 4899-4913. PMID 9671498 DOI: 10.1128/Mcb.18.8.4899 |
0.411 |
|
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