| Year |
Citation |
Score |
| 2019 |
Kall SL, Whitlatch K, Smithgall TE, Lavie A. Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase. Scientific Reports. 9: 17121. PMID 31745227 DOI: 10.1038/S41598-019-53447-0 |
0.504 |
|
| 2019 |
Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, ... ... Lavie A, et al. Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chemical Biology. PMID 31734178 DOI: 10.1016/J.Chembiol.2019.10.012 |
0.377 |
|
| 2018 |
Kokoszka ME, Kall SL, Khosla S, McGinnis JE, Lavie A, Kay BK. Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3. The Journal of Biological Chemistry. PMID 29980598 DOI: 10.1074/Jbc.Ra117.000262 |
0.439 |
|
| 2018 |
Venegas LA, Kall SL, Bankole O, Lavie A, Kay B. Generating a recombinant phosphothreonine-binding domain for a phosphopeptide of the human transcription factor, c-Myc. New Biotechnology. PMID 29763736 DOI: 10.1016/J.Nbt.2018.05.001 |
0.431 |
|
| 2018 |
Kall SL, Delikatny E, Lavie A. Identification of a Unique Inhibitor Binding Site on Choline Kinase alpha. Biochemistry. PMID 29389115 DOI: 10.1021/Acs.Biochem.7B01257 |
0.465 |
|
| 2017 |
Kingsley CN, Antanasijevic A, Palka-Hamblin H, Durst M, Ramirez B, Lavie A, Caffrey M. Probing the metastable state of influenza hemagglutinin. The Journal of Biological Chemistry. PMID 29127198 DOI: 10.1074/Jbc.M117.815043 |
0.348 |
|
| 2017 |
Rigouin C, Nguyen HA, Schalk AM, Lavie A. Discovery of human-like L-asparaginases with potential clinical use by directed evolution. Scientific Reports. 7: 10224. PMID 28860480 DOI: 10.1038/S41598-017-10758-4 |
0.304 |
|
| 2017 |
Nguyen HA, Durden DL, Lavie A. The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity. Scientific Reports. 7: 41643. PMID 28139703 DOI: 10.1038/Srep41643 |
0.375 |
|
| 2016 |
Koduvayur SP, Su Y, Kay BK, Lavie A. Targeted Delivery of Deoxycytidine Kinase to Her2-Positive Cells Enhances the Efficacy of the Nucleoside Analog Fludarabine. Plos One. 11: e0157114. PMID 27280468 DOI: 10.1371/Journal.Pone.0157114 |
0.379 |
|
| 2016 |
Nguyen HA, Su Y, Lavie A. Structural insight into substrate selectivity of Erwinia chrysanthemi L-asparaginase. Biochemistry. PMID 26855287 DOI: 10.1021/Acs.Biochem.5B01351 |
0.331 |
|
| 2016 |
Schalk AM, Antansijevic A, Caffrey M, Lavie A. Experimental Data in Support of a Direct Displacement Mechanism for Type I/II l-Asparaginases. The Journal of Biological Chemistry. 291: 5088-100. PMID 26733195 DOI: 10.1074/Jbc.M115.699884 |
0.397 |
|
| 2015 |
Nomme J, Antanasijevic A, Caffrey M, Van Itallie CM, Anderson JM, Fanning AS, Lavie A. Structural basis of a key factor regulating the affinity between the zonula occludens first PDZ domain and claudins. The Journal of Biological Chemistry. PMID 26023235 DOI: 10.1074/Jbc.M115.646695 |
0.468 |
|
| 2014 |
Nomme J, Li Z, Gipson RM, Wang J, Armijo AL, Le T, Poddar S, Smith T, Santarsiero BD, Nguyen HA, Czernin J, Alexandrova AN, Jung ME, Radu CG, Lavie A. Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. Journal of Medicinal Chemistry. 57: 9480-94. PMID 25341194 DOI: 10.1021/Jm501124J |
0.4 |
|
| 2014 |
Schalk AM, Nguyen HA, Rigouin C, Lavie A. Identification and structural analysis of an L-asparaginase enzyme from guinea pig with putative tumor cell killing properties. The Journal of Biological Chemistry. 289: 33175-86. PMID 25320094 DOI: 10.1074/Jbc.M114.609552 |
0.409 |
|
| 2014 |
Nomme J, Su Y, Lavie A. Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis. Journal of Molecular Biology. 426: 2471-85. PMID 24768817 DOI: 10.1016/J.Jmb.2014.04.016 |
0.468 |
|
| 2014 |
Schalk AM, Lavie A. Structural and kinetic characterization of guinea pig L-asparaginase type III. Biochemistry. 53: 2318-28. PMID 24669941 DOI: 10.1021/Bi401692V |
0.41 |
|
| 2014 |
Ratia K, Light SH, Antanasijevic A, Anderson WF, Caffrey M, Lavie A. Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase Plos One. 9. PMID 24586713 DOI: 10.1371/Journal.Pone.0089356 |
0.304 |
|
| 2014 |
Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, ... ... Lavie A, et al. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. The Journal of Experimental Medicine. 211: 473-86. PMID 24567448 DOI: 10.1084/Jem.20131738 |
0.311 |
|
| 2014 |
Light SH, Antanasijevic A, Krishna SN, Caffrey M, Anderson WF, Lavie A. Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation. Biochemistry. 53: 872-80. PMID 24437575 DOI: 10.1021/Bi4015506 |
0.449 |
|
| 2014 |
Nomme J, Murphy JM, Su Y, Sansone ND, Armijo AL, Olson ST, Radu C, Lavie A. Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules. Acta Crystallographica. Section D, Biological Crystallography. 70: 68-78. PMID 24419380 DOI: 10.1107/S1399004713025030 |
0.515 |
|
| 2013 |
Sato T, Neschadim A, Lavie A, Yanagisawa T, Medin JA. The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer. Plos One. 8: e78711. PMID 24194950 DOI: 10.1371/Journal.Pone.0078711 |
0.308 |
|
| 2013 |
Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, ... ... Lavie A, et al. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. Journal of Medicinal Chemistry. 56: 6696-708. PMID 23947754 DOI: 10.1021/Jm400457Y |
0.317 |
|
| 2013 |
Su Y, Karamitros CS, Nomme J, McSorley T, Konrad M, Lavie A. Free glycine accelerates the autoproteolytic activation of human asparaginase. Chemistry & Biology. 20: 533-40. PMID 23601642 DOI: 10.1016/J.Chembiol.2013.03.006 |
0.404 |
|
| 2013 |
Light SH, Krishna SN, Bergan RC, Lavie A, Anderson WF. Crystal structure of a type II dehydroquinate dehydratase-like protein from Bifidobacterium longum. Journal of Structural and Functional Genomics. 14: 25-30. PMID 23539270 DOI: 10.1007/S10969-013-9149-7 |
0.366 |
|
| 2013 |
Light SH, Anderson WF, Lavie A. Reassessing the Type i dehydroquinate dehydratase catalytic triad: Kinetic and structural studies of Glu86 mutants Protein Science. 22: 418-424. PMID 23341204 DOI: 10.1002/Pro.2218 |
0.466 |
|
| 2012 |
Nomme J, Su Y, Konrad M, Lavie A. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. Biochemistry. 51: 6816-26. PMID 22861376 DOI: 10.1021/Bi300870G |
0.444 |
|
| 2012 |
Gruber J, See Too WC, Wong MT, Lavie A, McSorley T, Konrad M. Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinase-targeted cancer therapy. The Febs Journal. 279: 1915-28. PMID 22429312 DOI: 10.1111/J.1742-4658.2012.08573.X |
0.366 |
|
| 2012 |
Neschadim A, Wang JC, Lavie A, Medin JA. Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer. Cancer Gene Therapy. 19: 320-7. PMID 22388453 DOI: 10.1038/Cgt.2012.4 |
0.328 |
|
| 2012 |
Neschadim A, Wang JC, Sato T, Fowler DH, Lavie A, Medin JA. Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1002-13. PMID 22273576 DOI: 10.1038/Mt.2011.298 |
0.346 |
|
| 2012 |
Campbell DO, Yaghoubi SS, Su Y, Lee JT, Auerbach MS, Herschman H, Satyamurthy N, Czernin J, Lavie A, Radu CG. Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe. The Journal of Biological Chemistry. 287: 446-54. PMID 22074768 DOI: 10.1074/Jbc.M111.314666 |
0.338 |
|
| 2011 |
Nomme J, Fanning AS, Caffrey M, Lye MF, Anderson JM, Lavie A. The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1. The Journal of Biological Chemistry. 286: 43352-60. PMID 22030391 DOI: 10.1074/Jbc.M111.304089 |
0.796 |
|
| 2011 |
Hazra S, Szewczak A, Ort S, Konrad M, Lavie A. Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release. Biochemistry. 50: 2870-80. PMID 21351740 DOI: 10.1021/Bi2001032 |
0.533 |
|
| 2011 |
Light SH, Minasov G, Shuvalova L, Peterson SN, Caffrey M, Anderson WF, Lavie A. A conserved surface loop in type i dehydroquinate dehydratases positions an active site arginine and functions in substrate binding Biochemistry. 50: 2357-2363. PMID 21291284 DOI: 10.1021/Bi102020S |
0.494 |
|
| 2011 |
Light SH, Minasov G, Shuvalova L, Duban ME, Caffrey M, Anderson WF, Lavie A. Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates Journal of Biological Chemistry. 286: 3531-3539. PMID 21087925 DOI: 10.1074/Jbc.M110.192831 |
0.473 |
|
| 2010 |
Hazra S, Konrad M, Lavie A. The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues. Journal of Medicinal Chemistry. 53: 5792-800. PMID 20684612 DOI: 10.1021/Jm1005379 |
0.524 |
|
| 2010 |
Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 49: 6784-90. PMID 20614893 DOI: 10.1021/Bi100839E |
0.512 |
|
| 2010 |
Foley DA, Swartzentruber KG, Lavie A, Colley KJ. Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites. The Journal of Biological Chemistry. 285: 27360-71. PMID 20573953 DOI: 10.1074/Jbc.M110.140038 |
0.406 |
|
| 2010 |
Lye MF, Fanning AS, Su Y, Anderson JM, Lavie A. Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module. The Journal of Biological Chemistry. 285: 13907-17. PMID 20200156 DOI: 10.1074/Jbc.M109.093674 |
0.8 |
|
| 2010 |
Kohler JJ, Hosseini SH, Cucoranu I, Zhelyabovska O, Green E, Ivey K, Abuin A, Fields E, Hoying A, Russ R, Santoianni R, Raper CM, Yang Q, Lavie A, Lewis W. Transgenic cardiac-targeted overexpression of human thymidylate kinase. Laboratory Investigation; a Journal of Technical Methods and Pathology. 90: 383-90. PMID 20065942 DOI: 10.1038/Labinvest.2009.146 |
0.319 |
|
| 2009 |
Hazra S, Sabini E, Ort S, Konrad M, Lavie A. Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. Biochemistry. 48: 1256-63. PMID 19159229 DOI: 10.1021/Bi802062W |
0.524 |
|
| 2008 |
Paarmann I, Lye MF, Lavie A, Konrad M. Structural requirements for calmodulin binding to membrane-associated guanylate kinase homologs. Protein Science : a Publication of the Protein Society. 17: 1946-54. PMID 18809851 DOI: 10.1110/Ps.035550.108 |
0.793 |
|
| 2008 |
Sabini E, Hazra S, Konrad M, Lavie A. Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase. Journal of Medicinal Chemistry. 51: 4219-25. PMID 18570408 DOI: 10.1021/Jm800134T |
0.479 |
|
| 2008 |
Lavie A, Su Y, Ghassemi M, Novak RM, Caffrey M, Sekulic N, Monnerjahn C, Konrad M, Cook JL. Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells. The Journal of General Virology. 89: 1672-9. PMID 18559937 DOI: 10.1099/Vir.0.2008/000273-0 |
0.702 |
|
| 2008 |
Sabini E, Hazra S, Ort S, Konrad M, Lavie A. Structural basis for substrate promiscuity of dCK. Journal of Molecular Biology. 378: 607-21. PMID 18377927 DOI: 10.1016/J.Jmb.2008.02.061 |
0.483 |
|
| 2008 |
McSorley T, Ort S, Hazra S, Lavie A, Konrad M. Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. Febs Letters. 582: 720-4. PMID 18258203 DOI: 10.1016/J.Febslet.2008.01.048 |
0.462 |
|
| 2007 |
Segura-Peña D, Lichter J, Trani M, Konrad M, Lavie A, Lutz S. Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes. Structure (London, England : 1993). 15: 1555-66. PMID 18073106 DOI: 10.1016/J.Str.2007.09.025 |
0.82 |
|
| 2007 |
Fanning AS, Lye MF, Anderson JM, Lavie A. Domain swapping within PDZ2 is responsible for dimerization of ZO proteins. The Journal of Biological Chemistry. 282: 37710-6. PMID 17928286 DOI: 10.1074/Jbc.M707255200 |
0.78 |
|
| 2007 |
Sekulic N, Konrad M, Lavie A. Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation. The Journal of Biological Chemistry. 282: 22112-21. PMID 17540769 DOI: 10.1074/Jbc.M701713200 |
0.786 |
|
| 2007 |
Sabini E, Hazra S, Konrad M, Lavie A. Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides. Journal of Medicinal Chemistry. 50: 3004-14. PMID 17530837 DOI: 10.1021/Jm0700215 |
0.458 |
|
| 2007 |
Segura-Peña D, Lutz S, Monnerjahn C, Konrad M, Lavie A. Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure. Journal of Molecular Biology. 369: 129-41. PMID 17407781 DOI: 10.1016/J.Jmb.2007.02.104 |
0.82 |
|
| 2007 |
Sato T, Neschadim A, Konrad M, Fowler DH, Lavie A, Medin JA. Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 962-70. PMID 17375075 DOI: 10.1038/Mt.Sj.6300122 |
0.325 |
|
| 2007 |
Sekulic N, Dietrich K, Paarmann I, Ort S, Konrad M, Lavie A. Elucidation of the active conformation of the APS-kinase domain of human PAPS synthetase 1. Journal of Molecular Biology. 367: 488-500. PMID 17276460 DOI: 10.1016/J.Jmb.2007.01.025 |
0.793 |
|
| 2007 |
Sabini E, Hazra S, Konrad M, Burley SK, Lavie A. Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic Acids Research. 35: 186-92. PMID 17158155 DOI: 10.1093/Nar/Gkl1038 |
0.637 |
|
| 2006 |
Malito E, Sekulic N, Too WC, Konrad M, Lavie A. Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. Journal of Molecular Biology. 364: 136-51. PMID 17007874 DOI: 10.1016/J.Jmb.2006.08.084 |
0.804 |
|
| 2006 |
Mendiratta SS, Sekulic N, Hernandez-Guzman FG, Close BE, Lavie A, Colley KJ. A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation. The Journal of Biological Chemistry. 281: 36052-9. PMID 17003032 DOI: 10.1074/Jbc.M608073200 |
0.696 |
|
| 2006 |
Godsey MH, Ort S, Sabini E, Konrad M, Lavie A. Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization. Biochemistry. 45: 452-61. PMID 16401075 DOI: 10.1021/Bi0518646 |
0.544 |
|
| 2006 |
Neschadim A, Sato T, Fowler DH, Lavie A, Medin JA. Development of Improved Lentiviral ‘Suicide’ Gene Therapy for the Management of GvHD and GvL/GvT Responses in Allogeneic BMT. Blood. 108: 3256-3256. DOI: 10.1182/Blood.V108.11.3256.3256 |
0.307 |
|
| 2005 |
Li Y, Fanning AS, Anderson JM, Lavie A. Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface. Journal of Molecular Biology. 352: 151-64. PMID 16081103 DOI: 10.1016/J.Jmb.2005.07.017 |
0.44 |
|
| 2005 |
Mendiratta SS, Sekulic N, Lavie A, Colley KJ. Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST. The Journal of Biological Chemistry. 280: 32340-8. PMID 16027151 DOI: 10.1074/Jbc.M506217200 |
0.732 |
|
| 2005 |
Sato T, Neschadim A, Rasaiah VI, Konrad M, Fowler DH, Lavie A, Medin JA. A Novel Suicide Gene Therapy Approach for Reduction of GvHD Using Lentiviral Delivery of a Modified Human Thymidylate Monophosphate Kinase. Blood. 106: 5252-5252. DOI: 10.1182/Blood.V106.11.5252.5252 |
0.311 |
|
| 2005 |
Sato T, Neschadim A, Rasaiah VI, Konrad M, Fowler DH, Lavie A, Medin JA. Improved Suicide Gene Therapy: Lentiviral Gene Transfer of Equine Herpes Virus Type 4 Thymidine Kinase into Target Cells. Blood. 106: 5251-5251. DOI: 10.1182/Blood.V106.11.5251.5251 |
0.319 |
|
| 2005 |
Sekulic N, Dietrich K, Paarmann I, Konrad M, Lavie A. Crystal structures of two domains of bifunctional enzyme: human PAPS synthetase Acta Crystallographica Section a Foundations of Crystallography. 61: c195-c196. DOI: 10.1107/S0108767305091671 |
0.326 |
|
| 2004 |
Li Y, Karnak D, Demeler B, Margolis B, Lavie A. Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. The Embo Journal. 23: 2723-33. PMID 15241471 DOI: 10.1038/Sj.Emboj.7600294 |
0.39 |
|
| 2004 |
Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A. Substrate-induced conformational changes in human UMP/CMP kinase. The Journal of Biological Chemistry. 279: 33882-9. PMID 15163660 DOI: 10.1074/Jbc.M401989200 |
0.801 |
|
| 2004 |
Lavie A, Konrad M. Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase. Mini Reviews in Medicinal Chemistry. 4: 351-9. PMID 15134538 DOI: 10.2174/1389557043403981 |
0.556 |
|
| 2003 |
Gardberg A, Shuvalova L, Monnerjahn C, Konrad M, Lavie A. Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases. Structure (London, England : 1993). 11: 1265-77. PMID 14527394 DOI: 10.1016/J.Str.2003.09.003 |
0.527 |
|
| 2003 |
Sabini E, Ort S, Monnerjahn C, Konrad M, Lavie A. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nature Structural Biology. 10: 513-9. PMID 12808445 DOI: 10.1038/Nsb942 |
0.5 |
|
| 2003 |
Ostermann N, Segura-Peña D, Meier C, Veit T, Monnerjahn C, Konrad M, Lavie A. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. Biochemistry. 42: 2568-77. PMID 12614151 DOI: 10.1021/Bi027302T |
0.822 |
|
| 2002 |
Paarmann I, Spangenberg O, Lavie A, Konrad M. Formation of complexes between Ca2+.calmodulin and the synapse-associated protein SAP97 requires the SH3 domain-guanylate kinase domain-connecting HOOK region. The Journal of Biological Chemistry. 277: 40832-8. PMID 12189141 DOI: 10.1074/Jbc.M205618200 |
0.481 |
|
| 2002 |
Sekulic N, Shuvalova L, Spangenberg O, Konrad M, Lavie A. Structural characterization of the closed conformation of mouse guanylate kinase. The Journal of Biological Chemistry. 277: 30236-43. PMID 12036965 DOI: 10.1074/Jbc.M204668200 |
0.799 |
|
| 2002 |
Li Y, Spangenberg O, Paarmann I, Konrad M, Lavie A. Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains. The Journal of Biological Chemistry. 277: 4159-65. PMID 11729206 DOI: 10.1074/Jbc.M110792200 |
0.518 |
|
| 2000 |
Ostermann N, Lavie A, Padiyar S, Brundiers R, Veit T, Reinstein J, Goody RS, Konrad M, Schlichting I. Potentiating AZT activation: Structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP Journal of Molecular Biology. 304: 43-53. PMID 11071809 DOI: 10.1006/Jmbi.2000.4175 |
0.65 |
|
| 2000 |
Ostermann N, Schlichting I, Brundiers R, Konrad M, Reinstein J, Veit T, Goody RS, Lavie A. Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate Structure. 8: 629-642. PMID 10873853 DOI: 10.1016/S0969-2126(00)00149-0 |
0.682 |
|
| 1999 |
Prinz H, Lavie A, Scheidig AJ, Spangenberg O, Konrad M. Binding of nucleotides to guanylate kinase, p21(ras), and nucleoside- diphosphate kinase studied by nano-electrospray mass spectrometry Journal of Biological Chemistry. 274: 35337-35342. PMID 10585400 DOI: 10.1074/Jbc.274.50.35337 |
0.472 |
|
| 1999 |
Brundiers R, Lavie A, Veit T, Reinstein J, Schlichting I, Ostermann N, Goody RS, Konrad M. Modifying human thymidylate kinase to potentiate azidothymidine activation Journal of Biological Chemistry. 274: 35289-35292. PMID 10585390 DOI: 10.1074/Jbc.274.50.35289 |
0.651 |
|
| 1998 |
Lavie A, Ostermann N, Brundiers R, Goody RS, Reinstein J, Konrad M, Schlichting I. Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase Proceedings of the National Academy of Sciences of the United States of America. 95: 14045-14050. PMID 9826650 DOI: 10.1073/Pnas.95.24.14045 |
0.642 |
|
| 1998 |
Lavie A, Konrad M, Brundiers R, Goody RS, Schlichting I, Reinstein J. Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 Å resolution: Implications for catalysis and AZT activation Biochemistry. 37: 3677-3686. PMID 9521686 DOI: 10.1021/Bi9720787 |
0.662 |
|
| 1998 |
Balzarini J, Degreve B, De Clercq E, Lavie A, Reinstein J, Goody RS, Schlichting I. Improving AZT efficacy Nature Medicine. 4: 132. PMID 9461164 DOI: 10.1038/Nm0298-132A |
0.45 |
|
| 1998 |
Lavie A, Reinstein J, Goody RS, Schlichting I, Konrad M. Reply to “Improving AZT efficacy” Nature Medicine. 4: 132-132. DOI: 10.1038/Nm0298-132B |
0.442 |
|
| 1997 |
Lavie A, Schlichting I, Vetter IR, Konrad M, Reinstein J, Goody RS. The bottleneck in AZT activation Nature Medicine. 3: 922-924. PMID 9256287 DOI: 10.1038/Nm0897-922 |
0.624 |
|
| 1997 |
Lavie A, Vetter IR, Konrad M, Goody RS, Reinstein J, Schlichting I. Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation Nature Structural Biology. 4: 601-604. PMID 9253404 DOI: 10.1038/Nsb0897-601 |
0.63 |
|
| 1996 |
Lavie A, Vetter I, Konrad M, Goody R, Reinstein J, Schlichting I. Crystal structure of thymidylate kinase fromSaccharomyces cerevisiaewith substrate bound Acta Crystallographica Section a Foundations of Crystallography. 52: C169-C169. DOI: 10.1107/S0108767396092525 |
0.585 |
|
| 1995 |
Allen KN, Lavie A, Petsko GA, Ringe D. Design, synthesis, and characterization of a potent xylose isomerase inhibitor, D-threonohydroxamic acid, and high-resolution X-ray crystallographic structure of the enzyme-inhibitor complex Biochemistry. 34: 3742-3749. PMID 7893671 DOI: 10.1021/Bi00011A032 |
0.707 |
|
| 1994 |
Allen KN, Lavie A, Farber GK, Glasfeld A, Petsko GA, Ringe D. Isotopic exchange plus substrate and inhibition kinetics of D-xylose isomerase do not support a proton-transfer mechanism Biochemistry. 33: 1481-1487. PMID 8312268 DOI: 10.1021/Bi00172A026 |
0.674 |
|
| 1994 |
Lavie A, Allen KN, Petsko GA, Ringe D. X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis Biochemistry. 33: 5469-5480. PMID 8180169 DOI: 10.2210/Pdb1Xyb/Pdb |
0.682 |
|
| 1994 |
Allen KN, Lavie A, Glasfeld A, Tanada TN, Gerrity DP, Carlson SC, Farber GK, Petsko GA, Ringe D. Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: Replacement of a catalytic metal by an amino acid Biochemistry. 33: 1488-1494. PMID 7906142 DOI: 10.1021/Bi00172A027 |
0.692 |
|
| 1993 |
Petsko G, Ringe D, Allen K, Lavie A, Gerhart-Mueller E, Clifton J, Hasson M, Fujita S, Sugio S, Xhang X, Davenport R, Lolis E, Neidhart D, Kenyon G, Gerlt J, et al. The structural enzymology of proton-transfer reactions Protein Engineering, Design and Selection. 6: 37. DOI: 10.1093/Protein/6.Supplement.37-A |
0.721 |
|
| Show low-probability matches. |
