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Jonathan Wanagat, Ph.D. - Publications

Affiliations: 
2000 University of Wisconsin, Madison, Madison, WI 
Area:
Cell Biology, Molecular Biology, Pathology
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Vandiver AR, Torres A, Sanden A, Nguyen TL, Gasilla J, Doan MT, Martirosian V, Hoang A, Wanagat J, Teitell MA. Increased mitochondrial mutation heteroplasmy induces aging phenotypes in pluripotent stem cells and their differentiated progeny. Aging Cell. e14402. PMID 39680477 DOI: 10.1111/acel.14402  0.392
2024 Vandiver AR, Herbst A, Stothard P, Wanagat J. Chimeric mitochondrial RNA transcripts predict mitochondrial genome deletion mutations in mitochondrial genetic diseases and aging. Genome Research. PMID 39603705 DOI: 10.1101/gr.279072.124  0.748
2024 Musci RV, Fuqua JD, Peelor FF, Nguyen HVM, Richardson A, Choi S, Miller BF, Wanagat J. Age-induced changes in skeletal muscle mitochondrial DNA synthesis, quantity, and quality in genetically unique rats. Geroscience. PMID 39312152 DOI: 10.1007/s11357-024-01344-4  0.593
2024 Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, et al. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Science Advances. 10: eadl0389. PMID 38569044 DOI: 10.1126/sciadv.adl0389  0.433
2023 Vandiver AR, Hoang AN, Herbst A, Lee CC, Aiken JM, McKenzie D, Teitell MA, Timp W, Wanagat J. Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial DNA deletion mutations in human aging. Aging Cell. e13842. PMID 37132288 DOI: 10.1111/acel.13842  0.805
2022 Herbst A, Choi S, Hoang AN, Kim C, Martinez Moreno D, McKenzie D, Aiken JM, Wanagat J. Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats: A short report. Plos One. 17: e0271850. PMID 36288327 DOI: 10.1371/journal.pone.0271850  0.799
2022 Herbst A, Aiken JM, Kim C, Gushue D, McKenzie D, Moore TM, Zhou J, Hoang AN, Choi S, Wanagat J. Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles. Geroscience. PMID 36178599 DOI: 10.1007/s11357-022-00667-4  0.831
2022 Vandiver AR, Pielstick B, Gilpatrick T, Hoang AN, Vernon HJ, Wanagat J, Timp W. Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation. Mitochondrion. 65: 176-183. PMID 35787470 DOI: 10.1016/j.mito.2022.06.003  0.329
2021 Herbst A, Hoang A, Kim C, Aiken J, McKenzie D, Goldwater D, Wanagat J. Metformin treatment in old rats and effects on mitochondrial integrity. Rejuvenation Research. PMID 34779265 DOI: 10.1089/rej.2021.0052  0.794
2021 Herbst A, Prior SJ, Lee CC, Aiken JM, McKenzie D, Hoang A, Liu N, Chen X, Xun P, Allison DB, Wanagat J. Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women. Geroscience. PMID 33740224 DOI: 10.1007/s11357-021-00351-z  0.818
2020 Moore TM, Zhou Z, Strumwasser AR, Cohn W, Lin AJ, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Hoang AN, Widjaja K, Abrishami AD, Charugundla S, ... ... Wanagat J, et al. Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge. Aging Cell. e13166. PMID 33049094 DOI: 10.1111/acel.13166  0.46
2020 Herbst A, Lee CC, Vandiver AR, Aiken JM, McKenzie D, Hoang A, Allison D, Liu N, Wanagat J. Mitochondrial DNA deletion mutations increase exponentially with age in human skeletal muscle. Aging Clinical and Experimental Research. PMID 32965609 DOI: 10.1007/s40520-020-01698-7  0.807
2020 Barthelemy F, Woods JD, Nieves-Rodriguez S, Douine ED, Wang R, Wanagat J, Miceli MC, Nelson SF. A well tolerated core needle muscle biopsy process suitable for children and adults. Muscle & Nerve. PMID 32820569 DOI: 10.1002/Mus.27041  0.441
2020 Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, et al. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating and mitochondrial remodeling. Science Translational Medicine. 12. PMID 32759275 DOI: 10.1126/Scitranslmed.Aax8096  0.367
2020 Herbst A, Aiken JM, McKenzie D, Wanagat J. Comment on: "Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. 2020, , 197". Cells. 9. PMID 32751058 DOI: 10.3390/Cells9081796  0.818
2020 Moore TM, Lin AJ, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQ, Yackly A, Mahata SK, Wanagat J, Stiles L, Turcotte LP, et al. Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in Mice. Frontiers in Physiology. 11: 690. PMID 32636760 DOI: 10.3389/Fphys.2020.00690  0.586
2020 Lee CC, Hoang A, Segovia D, Herbst A, Barthelemy F, Gibbs E, Crosbie R, Nelson SF, Miceli C, Wanagat J. Enhanced Methods for Needle Biopsy and Cryopreservation of Skeletal Muscle in Older Adults. Journal of Cytology & Histology. 11. PMID 32566369 DOI: 10.37421/Jch.2020.11.553  0.733
2020 Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AM, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, et al. A novel approach to measure mitochondrial respiration in frozen biological samples. The Embo Journal. e104073. PMID 32432379 DOI: 10.15252/Embj.2019104073  0.403
2020 Lee CC, Hoang A, Segovia D, Herbst A, Barthelemy F, Gibbs E, Crosbie R, Nelson SF, Miceli C, Wanagat J. Enhanced Methods for Needle Biopsy and Cryopreservation of Skeletal Muscle in Older Adults Journal of Cytology & Histology. 11. DOI: 10.37421/jch.2020.11.553  0.305
2020 Moore TM, Lin AJ, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQ, Yackly A, Mahata SK, Wanagat J, Stiles L, Turcotte LP, et al. Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice Frontiers in Physiology. 11. DOI: 10.3389/fphys.2020.00690  0.321
2019 Herbst A, Hoang AN, Woo W, McKenzie D, Aiken JM, Miller RA, Allison DB, Liu N, Wanagat J. Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice. Mechanisms of Ageing and Development. 111126. PMID 31381889 DOI: 10.1016/J.Mad.2019.111126  0.814
2019 Kim MJ, Haroon S, Chen GD, Ding D, Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K, Linser PJ, Tanokura M, et al. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. Experimental Gerontology. 110675. PMID 31344454 DOI: 10.1016/J.Exger.2019.110675  0.51
2018 Bielas J, Herbst A, Widjaja K, Hui J, Aiken JM, McKenzie D, Miller RA, Brooks S, Wanagat J. Long term rapamycin treatment improves mitochondrial DNA quality in aging mice. Experimental Gerontology. PMID 29486228 DOI: 10.1016/J.Exger.2018.02.021  0.823
2017 Herbst A, Widjaja K, Nguy B, Lushaj EB, Moore TM, Hevener AL, McKenzie D, Aiken JM, Wanagat J. Digital PCR Quantitation of Muscle Mitochondrial DNA: Age, Fiber Type, and Mutation-Induced Changes. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 28460005 DOI: 10.1093/Gerona/Glx058  0.846
2016 Herbst A, Wanagat J, Cheema N, Widjaja K, McKenzie D, Aiken JM. Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age. Aging Cell. PMID 27561813 DOI: 10.1111/Acel.12520  0.844
2016 Wanagat J, Hevener AL. Mitochondrial quality control in insulin resistance and diabetes. Current Opinion in Genetics & Development. 38: 118-126. PMID 27318536 DOI: 10.1016/J.Gde.2016.05.007  0.388
2016 Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, et al. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Science Translational Medicine. 8: 334ra54. PMID 27075628 DOI: 10.1126/Scitranslmed.Aad3815  0.521
2015 Wanagat J, Ahmadieh N, Bielas JH, Ericson NG, Van Remmen H. Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice. Experimental Gerontology. 61: 15-9. PMID 25449857 DOI: 10.1016/J.Exger.2014.11.012  0.636
2014 Drew BG, Ribas V, Le JA, Henstridge DC, Phun J, Zhou Z, Soleymani T, Daraei P, Sitz D, Vergnes L, Wanagat J, Reue K, Febbraio MA, Hevener AL. HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes. 63: 1488-505. PMID 24379352 DOI: 10.2337/Db13-0665  0.458
2013 Ahuja P, Wanagat J, Wang Z, Wang Y, Liem DA, Ping P, Antoshechkin IA, Margulies KB, Maclellan WR. Divergent mitochondrial biogenesis responses in human cardiomyopathy. Circulation. 127: 1957-67. PMID 23589024 DOI: 10.1161/Circulationaha.112.001219  0.367
2010 Wanagat J, Dai DF, Rabinovitch P. Mitochondrial oxidative stress and mammalian healthspan. Mechanisms of Ageing and Development. 131: 527-35. PMID 20566356 DOI: 10.1016/J.Mad.2010.06.002  0.423
2010 Kulawiec M, Salk JJ, Ericson NG, Wanagat J, Bielas JH. Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer. Environmental and Molecular Mutagenesis. 51: 427-39. PMID 20544883 DOI: 10.1002/Em.20582  0.452
2010 Dai DF, Chen T, Wanagat J, Laflamme M, Marcinek DJ, Emond MJ, Ngo CP, Prolla TA, Rabinovitch PS. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell. 9: 536-44. PMID 20456298 DOI: 10.1111/J.1474-9726.2010.00581.X  0.539
2010 Ladiges W, Wanagat J, Preston B, Loeb L, Rabinovitch P. A Mitochondrial view of aging, reactive oxygen species and metastatic cancer Aging Cell. 9: 462-465. PMID 20456297 DOI: 10.1111/J.1474-9726.2010.00579.X  0.406
2010 Marcinek DJ, Wanagat J, Rabinovitch PS, Voss J. 75 Protective effect of mitochondrial catalase on AZT mitochondrial toxicity Mitochondrion. 10: 221. DOI: 10.1016/J.Mito.2009.12.070  0.436
2010 Marcinek DJ, Wanagat J, Villarin JJ. Comparative skeletal muscle aging The Comparative Biology of Aging. 287-317. DOI: 10.1007/978-90-481-3465-6-13  0.469
2009 Vermulst M, Wanagat J, Loeb LA. On Mitochondria, Mutations, and Methodology Cell Metabolism. 10: 437. PMID 19945399 DOI: 10.1016/J.Cmet.2009.11.001  0.482
2008 Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice Nature Genetics. 40: 392-394. PMID 18311139 DOI: 10.1038/Ng.95  0.552
2007 McKiernan SH, Tuen VC, Baldwin K, Wanagat J, Djamali A, Aiken JM. Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells. American Journal of Physiology. Renal Physiology. 292: F1751-60. PMID 17344189 DOI: 10.1152/Ajprenal.00307.2006  0.702
2006 Hacker TA, McKiernan SH, Douglas PS, Wanagat J, Aiken JM. Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats. American Journal of Physiology. Heart and Circulatory Physiology. 290: H304-11. PMID 16143657 DOI: 10.1152/Ajpheart.00290.2005  0.607
2002 Bua EA, McKiernan SH, Wanagat J, McKenzie D, Aiken JM. Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia. Journal of Applied Physiology (Bethesda, Md. : 1985). 92: 2617-24. PMID 12015381 DOI: 10.1152/Japplphysiol.01102.2001  0.801
2002 Aiken J, Bua E, Cao Z, Lopez M, Wanagat J, McKenzie D, McKiernan S. Mitochondrial DNA deletion mutations and sarcopenia. Annals of the New York Academy of Sciences. 959: 412-23. PMID 11976214 DOI: 10.1111/J.1749-6632.2002.Tb02111.X  0.801
2002 Wanagat J, Wolff MR, Aiken JM. Age-associated changes in function, structure and mitochondrial genetic and enzymatic abnormalities in the Fischer 344 x Brown Norway F(1) hybrid rat heart. Journal of Molecular and Cellular Cardiology. 34: 17-28. PMID 11812161 DOI: 10.1006/Jmcc.2001.1483  0.693
2001 Cao Z, Wanagat J, McKiernan SH, Aiken JM. Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Research. 29: 4502-8. PMID 11691938 DOI: 10.1093/Nar/29.21.4502  0.776
2001 Wanagat J, Cao Z, Pathare P, Aiken JM. Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 322-32. PMID 11156948 DOI: 10.1096/Fj.00-0320Com  0.817
1999 Wanagat J, Allison DB, Weindruch R. Caloric intake and aging: Mechanisms in rodents and a study in nonhuman primates Toxicological Sciences. 52: 35-40. PMID 10630588 DOI: 10.1093/Toxsci/52.Suppl_1.35  0.329
1999 Van Zeeland NL, Wanagat J, Lopez ME, Aiken JM. Segmental nature of age-associated, skeletal muscle mitochondrial abnormalities necessitates three-dimensional analyses Journal of Anti-Aging Medicine. 2: 231-241. DOI: 10.1089/Rej.1.1999.2.231  0.821
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