Roger K. Sunahara - Publications

Chemical Biology University of Michigan, Ann Arbor, Ann Arbor, MI 
General, General Biophysics, Pharmacology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Cai Y, Liu Y, Culhane KJ, DeVree BT, Yang Y, Sunahara RK, Yan ECY. Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. Plos One. 12: e0179568. PMID 28609478 DOI: 10.1371/journal.pone.0179568  0.32
2016 DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. PMID 27362234 DOI: 10.1038/nature18324  0.44
2015 Mallik L, Dhakal S, Nichols J, Mahoney J, Dosey AM, Jiang S, Sunahara RK, Skiniotis G, Walter NG. Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami. Acs Nano. PMID 26149412 DOI: 10.1021/acsnano.5b01841  0.44
2015 Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science (New York, N.Y.). 348: 1361-5. PMID 26089515 DOI: 10.1126/science.aaa5264  0.44
2013 Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S. Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. The Journal of Biological Chemistry. 288: 17167-78. PMID 23629648 DOI: 10.1074/jbc.M113.464065  0.44
2013 Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 495: 534-8. PMID 23515162 DOI: 10.1038/nature12000  0.44
2013 Chung KY, Day PW, Vélez-Ruiz G, Sunahara RK, Kobilka BK. Identification of GPCR-interacting cytosolic proteins using HDL particles and mass spectrometry-based proteomic approach. Plos One. 8: e54942. PMID 23372797 DOI: 10.1371/journal.pone.0054942  0.44
2013 Mitra N, Liu Y, Liu J, Serebryany E, Mooney V, DeVree BT, Sunahara RK, Yan EC. Calcium-dependent ligand binding and G-protein signaling of family B GPCR parathyroid hormone 1 receptor purified in nanodiscs. Acs Chemical Biology. 8: 617-25. PMID 23237450 DOI: 10.1021/cb300466n  0.44
2012 Collins GT, Brim RL, Noon KR, Narasimhan D, Lukacs NW, Sunahara RK, Woods JH, Ko MC. Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 342: 205-13. PMID 22518021 DOI: 10.1124/jpet.112.194639  0.44
2012 Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 485: 321-6. PMID 22437502 DOI: 10.1038/nature10954  0.44
2012 Lee TY, Park YS, Garcia GA, Sunahara RK, Woods JH, Yang VC. Cell permeable cocaine esterases constructed by chemical conjugation and genetic recombination. Molecular Pharmaceutics. 9: 1361-73. PMID 22404344 DOI: 10.1021/mp200623w  0.44
2012 Narasimhan D, Woods JH, Sunahara RK. Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction. Future Medicinal Chemistry. 4: 137-50. PMID 22300094 DOI: 10.4155/fmc.11.194  0.44
2012 Collins GT, Narasimhan D, Cunningham AR, Zaks ME, Nichols J, Ko MC, Sunahara RK, Woods JH. Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1092-103. PMID 21993206 DOI: 10.1038/npp.2011.226  0.44
2012 Brim RL, Noon KR, Collins GT, Stein A, Nichols J, Narasimhan D, Ko MC, Woods JH, Sunahara RK. The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination. The Journal of Pharmacology and Experimental Therapeutics. 340: 83-95. PMID 21990608 DOI: 10.1124/jpet.111.186049  0.44
2011 Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL, Sunahara RK. Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature. 477: 611-5. PMID 21956331 DOI: 10.1038/nature10488  0.44
2011 Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL, Steyaert J, ... ... Sunahara RK, et al. Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 16086-91. PMID 21914848 DOI: 10.1073/pnas.1113645108  0.44
2011 Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J, Ko MC, Woods JH, Tesmer JJ, Sunahara RK. Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time. Molecular Pharmacology. 80: 1056-65. PMID 21890748 DOI: 10.1124/mol.111.074997  0.44
2011 Brim RL, Noon KR, Collins GT, Nichols J, Narasimhan D, Sunahara RK, Woods JH. The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry. Molecular Pharmacology. 80: 1119-27. PMID 21885621 DOI: 10.1124/mol.111.074534  0.44
2011 Brim RL, Noon KR, Nichols J, Narasimhan D, Woods JH, Sunahara RK. Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs. Drug and Alcohol Dependence. 119: 224-8. PMID 21775073 DOI: 10.1016/j.drugalcdep.2011.06.018  0.44
2011 Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, ... ... Sunahara RK, et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature. 477: 549-55. PMID 21772288 DOI: 10.1038/nature10361  0.44
2011 Collins GT, Zaks ME, Cunningham AR, St Clair C, Nichols J, Narasimhan D, Ko MC, Sunahara RK, Woods JH. Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats. Drug and Alcohol Dependence. 118: 158-65. PMID 21481548 DOI: 10.1016/j.drugalcdep.2011.03.015  0.44
2011 Collins GT, Carey KA, Narasimhan D, Nichols J, Berlin AA, Lukacs NW, Sunahara RK, Woods JH, Ko MC. Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1047-59. PMID 21289605 DOI: 10.1038/npp.2010.242  0.44
2011 Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, et al. Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature. 469: 236-40. PMID 21228876 DOI: 10.1038/nature09665  0.44
2011 Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, et al. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature. 469: 175-80. PMID 21228869 DOI: 10.1038/nature09648  0.44
2010 Narasimhan D, Nance MR, Gao D, Ko MC, Macdonald J, Tamburi P, Yoon D, Landry DM, Woods JH, Zhan CG, Tesmer JJ, Sunahara RK. Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Engineering, Design & Selection : Peds. 23: 537-47. PMID 20436035 DOI: 10.1093/protein/gzq025  0.44
2010 Brim RL, Nance MR, Youngstrom DW, Narasimhan D, Zhan CG, Tesmer JJ, Sunahara RK, Woods JH. A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Molecular Pharmacology. 77: 593-600. PMID 20086035 DOI: 10.1124/mol.109.060806  0.44
2010 Park JB, Kwon YM, Lee TY, Brim R, Ko MC, Sunahara RK, Woods JH, Yang VC. PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity. Journal of Controlled Release : Official Journal of the Controlled Release Society. 142: 174-9. PMID 19857534 DOI: 10.1016/j.jconrel.2009.10.015  0.44
2010 Wood SK, Narasimhan D, Cooper Z, Sunahara RK, Woods JH. Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats. Drug and Alcohol Dependence. 106: 219-29. PMID 19800183 DOI: 10.1016/j.drugalcdep.2009.09.001  0.44
2009 Fung JJ, Deupi X, Pardo L, Yao XJ, Velez-Ruiz GA, Devree BT, Sunahara RK, Kobilka BK. Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. The Embo Journal. 28: 3315-28. PMID 19763081 DOI: 10.1038/emboj.2009.267  0.44
2009 Collins GT, Brim RL, Narasimhan D, Ko MC, Sunahara RK, Zhan CG, Woods JH. Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. The Journal of Pharmacology and Experimental Therapeutics. 331: 445-55. PMID 19710369 DOI: 10.1124/jpet.108.150029  0.44
2009 Kuszak AJ, Pitchiaya S, Anand JP, Mosberg HI, Walter NG, Sunahara RK. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. The Journal of Biological Chemistry. 284: 26732-41. PMID 19542234 DOI: 10.1074/jbc.M109.026922  0.44
2009 Yao XJ, Vélez Ruiz G, Whorton MR, Rasmussen SG, DeVree BT, Deupi X, Sunahara RK, Kobilka B. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proceedings of the National Academy of Sciences of the United States of America. 106: 9501-6. PMID 19470481 DOI: 10.1073/pnas.0811437106  0.44
2009 Ko MC, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Woods JH. Effects of cocaine esterase following its repeated administration with cocaine in mice. Drug and Alcohol Dependence. 101: 202-9. PMID 19217723 DOI: 10.1016/j.drugalcdep.2009.01.002  0.44
2009 Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, et al. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. The Journal of Pharmacology and Experimental Therapeutics. 329: 210-7. PMID 19136638 DOI: 10.1124/jpet.108.144048  0.44
2009 Jutkiewicz EM, Baladi MG, Cooper ZD, Narasimhan D, Sunahara RK, Woods JH. A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. Annals of Emergency Medicine. 54: 409-20. PMID 19013687 DOI: 10.1016/j.annemergmed.2008.09.023  0.44
2009 Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Molecular Pharmacology. 75: 318-23. PMID 18987161 DOI: 10.1124/mol.108.049486  0.44
2008 Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. The Journal of Biological Chemistry. 283: 4387-94. PMID 18033822 DOI: 10.1074/jbc.M703346200  0.44
2007 Cunliffe JM, Sunahara RK, Kennedy RT. Detection of g protein coupled receptor mediated adenylyl cyclase activity by capillary electrophoresis using fluorescently labeled ATP. Analytical Chemistry. 79: 7534-9. PMID 17718540 DOI: 10.1021/ac071203+  0.44
2007 Vadakkadathmeethal K, Cunliffe JM, Swift J, Kennedy RT, Neubig RR, Sunahara RK. Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening. Combinatorial Chemistry & High Throughput Screening. 10: 289-98. PMID 17506713 DOI: 10.2174/138620707780636600  0.44
2007 Cunliffe JM, Whorton MR, Sunahara RK, Kennedy RT. A CE assay for the detection of agonist-stimulated adenylyl cyclase activity. Electrophoresis. 28: 1913-20. PMID 17480040 DOI: 10.1002/elps.200600571  0.44
2007 Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara RK. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proceedings of the National Academy of Sciences of the United States of America. 104: 7682-7. PMID 17452637 DOI: 10.1073/pnas.0611448104  0.44
2007 Benson MD, Li QJ, Kieckhafer K, Dudek D, Whorton MR, Sunahara RK, Iñiguez-Lluhí JA, Martens JR. SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proceedings of the National Academy of Sciences of the United States of America. 104: 1805-10. PMID 17261810 DOI: 10.1073/pnas.0606702104  0.44
2007 Bodenstein J, Sunahara RK, Neubig RR. N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Molecular Pharmacology. 71: 1040-50. PMID 17220356 DOI: 10.1124/mol.106.029397  0.44
2007 Ko MC, Bowen LD, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Cooper ZD, Woods JH. Cocaine esterase: interactions with cocaine and immune responses in mice. The Journal of Pharmacology and Experimental Therapeutics. 320: 926-33. PMID 17114567 DOI: 10.1124/jpet.106.114223  0.44
2007 Walter NG, Meiners JC, Meyhofer E, Neubig RR, Sunahara RK, Perkins NC, Steel DG, Swanson JA. Under the microscope: single molecule symposium at the University of Michigan, 2006. Biopolymers. 85: 106-14. PMID 17080420 DOI: 10.1002/bip.20621  0.44
2007 Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/mol.106.028670  0.44
2006 Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Molecular Pharmacology. 70: 1885-91. PMID 16968810 DOI: 10.1124/mol.106.025999  0.44
2006 Giguère P, Rochdi MD, Laroche G, Dupré E, Whorton MR, Sunahara RK, Claing A, Dupuis G, Parent JL. ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6. Cellular Signalling. 18: 1988-94. PMID 16650966 DOI: 10.1016/j.cellsig.2006.03.003  0.44
2006 Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/j.1747-0285.2006.00373.x  0.44
2006 Cunliffe JM, Sunahara RK, Kennedy RT. Detection of adenylyl cyclase activity using a fluorescent ATP substrate and capillary electrophoresis. Analytical Chemistry. 78: 1731-8. PMID 16536404 DOI: 10.1021/ac0521201  0.44
2005 Morishima Y, Peng HM, Lin HL, Hollenberg PF, Sunahara RK, Osawa Y, Pratt WB. Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry. 44: 16333-40. PMID 16331994 DOI: 10.1021/bi0515570  0.44
2005 Chang FJ, Lemme S, Sun Q, Sunahara RK, Beuve A. Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase Journal of Biological Chemistry. 280: 11513-11519. PMID 15649897 DOI: 10.1074/jbc.M412203200  0.44
2005 Jameson EE, Roof RA, Whorton MH, Mosberg HI, Sunahara RK, Neubig RR, Kennedy RT. Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues Journal of Biological Chemistry. 280: 7712-7719. PMID 15613467 DOI: 10.1074/jbc.M413810200  0.44
2004 Whelan RJ, Sunahara RK, Neubig RR, Kennedy RT. Affinity assays using fluorescence anisotropy with capillary electrophoresis separation. Analytical Chemistry. 76: 7380-6. PMID 15595883 DOI: 10.1021/ac0489566  0.44
2004 Klein C, Heyduk T, Sunahara RK. Zinc inhibition of adenylyl cyclase correlates with conformational changes in the enzyme. Cellular Signalling. 16: 1177-85. PMID 15240012 DOI: 10.1016/j.cellsig.2004.03.008  0.44
2004 Krumins AM, Barker SA, Huang C, Sunahara RK, Yu K, Wilkie TM, Gold SJ, Mumby SM. Differentially regulated expression of endogenous RGS4 and RGS7. The Journal of Biological Chemistry. 279: 2593-9. PMID 14604980 DOI: 10.1074/jbc.M311600200  0.44
2003 Jameson EE, Cunliffe JM, Neubig RR, Sunahara RK, Kennedy RT. Detection of G proteins by affinity probe capillary electrophoresis using a fluorescently labeled GTP analogue Analytical Chemistry. 75: 4297-4304. PMID 14632149 DOI: 10.1021/ac0342976  0.44
2003 Morishima Y, Kanelakis KC, Murphy PJ, Lowe ER, Jenkins GJ, Osawa Y, Sunahara RK, Pratt WB. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. The Journal of Biological Chemistry. 278: 48754-63. PMID 14507910 DOI: 10.1074/jbc.M309814200  0.44
2002 Klein C, Sunahara RK, Hudson TY, Heyduk T, Howlett AC. Zinc inhibition of cAMP signaling. The Journal of Biological Chemistry. 277: 11859-65. PMID 11805091 DOI: 10.1074/jbc.M108808200  0.44
2002 Tesmer JJ, Sunahara RK, Fancy DA, Gilman AG, Sprang SR. Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha. Methods in Enzymology. 345: 198-206. PMID 11665605 DOI: 10.1016/S0076-6879(02)45017-3  0.44
2002 Hatley ME, Gilman AG, Sunahara RK. Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods in Enzymology. 345: 127-40. PMID 11665600 DOI: 10.1016/S0076-6879(02)45012-4  0.44
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