| Year |
Citation |
Score |
| 2024 |
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell MJ, Utsumi T, Pereira J, Iwakiri Y. Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features. Jhep Reports : Innovation in Hepatology. 6: 101069. PMID 38966234 DOI: 10.1016/j.jhepr.2024.101069 |
0.353 |
|
| 2024 |
Iwakiri Y. Unlocking the Role of Liver Sinusoidal Endothelial Cells: Key Players in Liver Fibrosis. Clinical and Molecular Hepatology. PMID 38726502 DOI: 10.3350/cmh.2024.0343 |
0.368 |
|
| 2023 |
Tanaka M, Jeong J, Thomas C, Zhang X, Zhang P, Saruwatari J, Kondo R, McConnell M, Utsumi T, Iwakiri Y. The sympathetic nervous system promotes hepatic lymphangiogenesis, which is protective against liver fibrosis. The American Journal of Pathology. PMID 37673329 DOI: 10.1016/j.ajpath.2023.08.004 |
0.35 |
|
| 2023 |
Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell MJ, Utsumi T, Iwakiri Y. An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 37605828 DOI: 10.1152/ajpgi.00139.2023 |
0.315 |
|
| 2023 |
Kondo R, Iwakiri Y, Kage M, Yano H. Endotheliopathy of liver sinusoidal endothelial cells in liver disease. Pathology International. 73: 381-393. PMID 37589433 DOI: 10.1111/pin.13361 |
0.362 |
|
| 2023 |
McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. The evolving role of liver sinusoidal endothelial cells in liver health and disease. Hepatology (Baltimore, Md.). PMID 36626620 DOI: 10.1097/HEP.0000000000000207 |
0.371 |
|
| 2022 |
Jeong J, Tanaka M, Iwakiri Y. Hepatic lymphatic vascular system in health and disease. Journal of Hepatology. PMID 35157960 DOI: 10.1016/j.jhep.2022.01.025 |
0.349 |
|
| 2021 |
Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, Yanagisawa H, Nagasaki T, Yasuda K, Oshiro S, Taura M, McConnell MJ, Oniki K, Sonoda K, Wakayama T, ... ... Iwakiri Y, et al. Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 34856227 DOI: 10.1016/j.jconrel.2021.11.039 |
0.312 |
|
| 2021 |
McConnell MJ, Kondo R, Kawaguchi N, Iwakiri Y. Covid-19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis. Hepatology Communications. PMID 34658172 DOI: 10.1002/hep4.1843 |
0.321 |
|
| 2021 |
Iwakiri Y, Trebicka J. Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy. Jhep Reports : Innovation in Hepatology. 3: 100316. PMID 34337369 DOI: 10.1016/j.jhepr.2021.100316 |
0.354 |
|
| 2020 |
Su T, Yang Y, Lai S, Jeong J, Jung Y, McConnell M, Utsumi T, Iwakiri Y. Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis. Cellular and Molecular Gastroenterology and Hepatology. PMID 33340713 DOI: 10.1016/j.jcmgh.2020.12.007 |
0.346 |
|
| 2020 |
Hsu SJ, Zhang C, Jeong J, Lee SI, McConnell M, Utsumi T, Iwakiri Y. Enhanced meningeal lymphatic drainage ameliorates neuroinflammation and hepatic encephalopathy in cirrhotic rats. Gastroenterology. PMID 33227282 DOI: 10.1053/j.gastro.2020.11.036 |
0.31 |
|
| 2020 |
Kondo R, Iwakiri Y. The lymphatic system in alcohol-associated liver disease. Clinical and Molecular Hepatology. PMID 32951411 DOI: 10.3350/Cmh.2020.0179 |
0.325 |
|
| 2020 |
Su T, Iwakiri Y. Novel endothelial LECT2/Tie1 signaling in liver fibrosis. Hepatology (Baltimore, Md.). PMID 32060947 DOI: 10.1002/Hep.31183 |
0.47 |
|
| 2019 |
Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, et al. O-GlcNAc transferase suppresses necroptosis and liver fibrosis. Jci Insight. 4. PMID 31672932 DOI: 10.1172/Jci.Insight.127709 |
0.429 |
|
| 2019 |
Zhao P, Han SN, Arumugam S, Yousaf MN, Qin Y, Jiang JX, Torok NJ, Chen Y, Mankash MS, Liu J, Li J, Iwakiri Y, Ouyang X. Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31411894 DOI: 10.1152/Ajpgi.00054.2019 |
0.418 |
|
| 2019 |
Cui J, Piotrowski-Daspit AS, Zhang J, Shao M, Bracaglia LG, Utsumi T, Seo YE, DiRito J, Song E, Wu C, Inada A, Tietjen GT, Pober JS, Iwakiri Y, Saltzman WM. Poly(amine-co-ester) nanoparticles for effective Nogo-B knockdown in the liver. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 31054286 DOI: 10.1016/J.Jconrel.2019.04.044 |
0.398 |
|
| 2018 |
Saruwatari J, Dong C, Utsumi T, Tanaka M, McConnell M, Iwakiri Y. Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats. Scientific Reports. 8: 17983. PMID 30573742 DOI: 10.1038/S41598-018-36297-0 |
0.353 |
|
| 2018 |
Tanaka M, Iwakiri Y. Lymphatics in the liver. Current Opinion in Immunology. 53: 137-142. PMID 29772409 DOI: 10.1016/J.Coi.2018.04.028 |
0.435 |
|
| 2018 |
Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, ... ... Iwakiri Y, et al. Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions. Drug Delivery. 25: 1067-1077. PMID 29688069 DOI: 10.1080/10717544.2018.1464083 |
0.353 |
|
| 2018 |
Lai S, Iwakiri Y. Is miR-21 a potent target for liver fibrosis? Hepatology (Baltimore, Md.). PMID 29315674 DOI: 10.1002/Hep.29774 |
0.317 |
|
| 2017 |
McConnell M, Iwakiri Y. Biology of portal hypertension. Hepatology International. PMID 29075990 DOI: 10.1007/S12072-017-9826-X |
0.446 |
|
| 2017 |
Bosch J, Iwakiri Y. The portal hypertension syndrome: etiology, classification, relevance, and animal models. Hepatology International. PMID 29064029 DOI: 10.1007/S12072-017-9827-9 |
0.393 |
|
| 2017 |
Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed FEZ, Davies N, Sharma V, Iwakiri Y, Jalan R. Corrigendum to "Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension" [J Hepatol 62 (2015) 325-331]. Journal of Hepatology. PMID 28893453 DOI: 10.1016/J.Jhep.2017.08.004 |
0.365 |
|
| 2017 |
Iwakiri Y, Nathanson MH. Alcohol and calcium make a potent cocktail. The Journal of Physiology. PMID 28295353 DOI: 10.1113/Jp274133 |
0.368 |
|
| 2017 |
Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y. An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of Kupffer cell polarization. Hepatology (Baltimore, Md.). PMID 28090670 DOI: 10.1002/Hep.29051 |
0.345 |
|
| 2016 |
Tanaka M, Iwakiri Y. The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis. Cellular and Molecular Gastroenterology and Hepatology. 2: 733-749. PMID 28105461 DOI: 10.1016/J.Jcmgh.2016.09.002 |
0.438 |
|
| 2016 |
Park JK, Utsumi T, Seo YE, Deng Y, Satoh A, Saltzman WM, Iwakiri Y. Cellular distribution of injected PLGA-nanoparticles in the liver. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26961463 DOI: 10.1016/J.Nano.2016.01.013 |
0.343 |
|
| 2015 |
Iwakiri Y. Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase. Clinical and Molecular Hepatology. 21: 319-25. PMID 26770919 DOI: 10.3350/Cmh.2015.21.4.319 |
0.458 |
|
| 2015 |
Protiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C. Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver. Cellular and Molecular Gastroenterology and Hepatology. 1: 535-549. PMID 26473164 DOI: 10.1016/J.Jcmgh.2015.06.006 |
0.338 |
|
| 2015 |
Iwakiri Y, Kim MY. Nitric oxide in liver diseases. Trends in Pharmacological Sciences. 36: 524-36. PMID 26027855 DOI: 10.1016/J.Tips.2015.05.001 |
0.464 |
|
| 2015 |
Wang S, Song K, Srivastava R, Dong C, Go GW, Li N, Iwakiri Y, Mani A. Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25917329 DOI: 10.1096/Fj.15-271171 |
0.409 |
|
| 2015 |
Kim MY, Iwakiri Y. Can hypersplenism secondary to portal hypertension be treated by non-selective beta blockers? Hepatology International. 9: 337-8. PMID 25788189 DOI: 10.1007/S12072-014-9601-1 |
0.404 |
|
| 2015 |
Hidaka H, Iwakiri Y. Hepatic congestion leads to fibrosis: findings in a newly developed murine model. Hepatology (Baltimore, Md.). 61: 428-30. PMID 25283276 DOI: 10.1002/Hep.27550 |
0.396 |
|
| 2015 |
Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed Fel Z, Davies N, Sharma V, Iwakiri Y, Jalan R. Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension. Journal of Hepatology. 62: 325-31. PMID 25152204 DOI: 10.1016/J.Jhep.2014.08.024 |
0.446 |
|
| 2014 |
Iwakiri Y, Shah V, Rockey DC. Vascular pathobiology in chronic liver disease and cirrhosis - current status and future directions. Journal of Hepatology. 61: 912-24. PMID 24911462 DOI: 10.1016/J.Jhep.2014.05.047 |
0.478 |
|
| 2014 |
Iwakiri Y. Pathophysiology of portal hypertension. Clinics in Liver Disease. 18: 281-91. PMID 24679494 DOI: 10.1002/9781119436812.Ch51 |
0.414 |
|
| 2014 |
Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C. Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology. 155: 1373-85. PMID 24456163 DOI: 10.1210/En.2013-1785 |
0.303 |
|
| 2013 |
Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC. eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases. Journal of Cell Science. 126: 5541-52. PMID 24046447 DOI: 10.1242/Jcs.115972 |
0.349 |
|
| 2013 |
Chung C, Iwakiri Y. The lymphatic vascular system in liver diseases: its role in ascites formation. Clinical and Molecular Hepatology. 19: 99-104. PMID 23837133 DOI: 10.3350/Cmh.2013.19.2.99 |
0.465 |
|
| 2013 |
Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y. Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice. The American Journal of Pathology. 182: 786-95. PMID 23313137 DOI: 10.1016/J.Ajpath.2012.11.032 |
0.361 |
|
| 2013 |
Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y. Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice. Hepatology (Baltimore, Md.). 57: 1992-2003. PMID 23299899 DOI: 10.1002/Hep.26235 |
0.378 |
|
| 2012 |
Chung C, Iwakiri Y. Activated hepatic stellate cells: negative regulators of hepatocyte proliferation in liver diseases. Hepatology (Baltimore, Md.). 56: 389-91. PMID 22876366 DOI: 10.1002/Hep.25761 |
0.43 |
|
| 2012 |
Sangwung P, Greco TM, Wang Y, Ischiropoulos H, Sessa WC, Iwakiri Y. Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. Plos One. 7: e31564. PMID 22363674 DOI: 10.1371/Journal.Pone.0031564 |
0.333 |
|
| 2012 |
Huang HC, Haq O, Utsumi T, Sethasine S, Abraldes JG, Groszmann RJ, Iwakiri Y. Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure. Journal of Cellular and Molecular Medicine. 16: 1125-33. PMID 21801303 DOI: 10.1111/J.1582-4934.2011.01399.X |
0.319 |
|
| 2012 |
Iwakiri Y. Endothelial dysfunction in the regulation of cirrhosis and portal hypertension. Liver International : Official Journal of the International Association For the Study of the Liver. 32: 199-213. PMID 21745318 DOI: 10.1111/J.1478-3231.2011.02579.X |
0.426 |
|
| 2011 |
Iwakiri Y. S-nitrosylation of proteins: a new insight into endothelial cell function regulated by eNOS-derived NO. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 25: 95-101. PMID 21554971 DOI: 10.1016/J.Niox.2011.04.014 |
0.335 |
|
| 2011 |
Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y. Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis. Hepatology (Baltimore, Md.). 53: 1306-15. PMID 21480333 DOI: 10.1002/Hep.24200 |
0.414 |
|
| 2008 |
Iwakiri Y, Grisham M, Shah V. Vascular biology and pathobiology of the liver: Report of a single-topic symposium. Hepatology (Baltimore, Md.). 47: 1754-63. PMID 18393322 DOI: 10.1002/Hep.22203 |
0.455 |
|
| 2007 |
Iwakiri Y. The molecules: mechanisms of arterial vasodilatation observed in the splanchnic and systemic circulation in portal hypertension. Journal of Clinical Gastroenterology. 41: S288-94. PMID 17975478 DOI: 10.1097/Mcg.0B013E3181468B4C |
0.328 |
|
| 2007 |
Lee CH, Loureiro-Silva MR, Abraldes JG, Iwakiri Y, Haq O, Groszmann RJ. Decreased intrahepatic response to alpha(1)-adrenergic agonists in lipopolysaccharide-treated rats is located in the sinusoidal area and depends on Kupffer cell function. Journal of Gastroenterology and Hepatology. 22: 893-900. PMID 17498219 DOI: 10.1111/J.1440-1746.2007.04922.X |
0.375 |
|
| 2007 |
Iwakiri Y, Groszmann RJ. Vascular endothelial dysfunction in cirrhosis. Journal of Hepatology. 46: 927-34. PMID 17391799 DOI: 10.1016/J.Jhep.2007.02.006 |
0.442 |
|
| 2007 |
Kwon SY, Groszmann RJ, Iwakiri Y. Increased neuronal nitric oxide synthase interaction with soluble guanylate cyclase contributes to the splanchnic arterial vasodilation in portal hypertensive rats. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 37: 58-67. PMID 17300699 DOI: 10.1111/J.1872-034X.2007.00005.X |
0.377 |
|
| 2006 |
Abraldes JG, Iwakiri Y, Loureiro-Silva M, Haq O, Sessa WC, Groszmann RJ. Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G980-7. PMID 16603731 DOI: 10.1152/Ajpgi.00336.2005 |
0.366 |
|
| 2006 |
Loureiro-Silva MR, Iwakiri Y, Abraldes JG, Haq O, Groszmann RJ. Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers. Journal of Hepatology. 44: 886-93. PMID 16545481 DOI: 10.1016/J.Jhep.2006.01.032 |
0.433 |
|
| 2006 |
Iwakiri Y, Groszmann RJ. The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. Hepatology (Baltimore, Md.). 43: S121-31. PMID 16447289 DOI: 10.1002/Hep.20993 |
0.351 |
|
| 2005 |
Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. The Journal of Clinical Investigation. 115: 2119-27. PMID 16075056 DOI: 10.1172/Jci24726 |
0.329 |
|
| 2003 |
Loureiro-Silva MR, Cadelina GW, Iwakiri Y, Groszmann RJ. A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats. Journal of Hepatology. 39: 940-6. PMID 14642609 DOI: 10.1016/J.Jhep.2003.09.018 |
0.461 |
|
| 2003 |
Tsai MH, Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Gastroenterology. 125: 1452-61. PMID 14598261 DOI: 10.1016/J.Gastro.2003.07.014 |
0.34 |
|
| 2003 |
TSAI M, IWAKIRI Y, CADELINA G, SESSA W, GROSZMANN R. Mesenteric vasoconstriction is responsible for the initial eNOS upregulation in the superior mesenteric artery of portal hypertensive rats Hepatology. 38: 176-177. DOI: 10.1016/S0270-9139(03)80088-5 |
0.319 |
|
| 2003 |
Loureiro-Silva M, Cadelina GW, Iwakiri Y, Groszmann RJ. 44 A liver-specific nitric oxide donor improves the intra-hepatic vascular response to increase portal blood flow and methoxamine in cirrhotic rats Hepatology. 38: 176-176. DOI: 10.1016/S0270-9139(03)80087-3 |
0.438 |
|
| 2002 |
Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G1074-81. PMID 12381520 DOI: 10.1152/Ajpgi.00145.2002 |
0.353 |
|
| 2002 |
Iwakiri Y, Tsai MH, McCabe TJ, Gratton JP, Fulton D, Groszmann RJ, Sessa WC. Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. American Journal of Physiology. Heart and Circulatory Physiology. 282: H2084-90. PMID 12003815 DOI: 10.1152/Ajpheart.00675.2001 |
0.328 |
|
| 2001 |
Iwakiri Y, Tsai M, Sessa WC, Groszmann RJ. The phosphorylation of endothelial nitric oxide synthase by Akt increases nitric oxide production in early portal hypertension Gastroenterology. 120: A9. DOI: 10.1016/S0016-5085(08)80044-3 |
0.331 |
|
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