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Julian Downward - Publications

Affiliations: 
Institute of Cancer Research, London, UK 
Area:
Cancer biology
Website:
https://www.crick.ac.uk/research/find-a-researcher/julian-downward
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Year Citation  Score
2023 Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ, Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, ... ... Downward J, et al. Lung adenocarcinoma promotion by air pollutants. Nature. 616: 159-167. PMID 37020004 DOI: 10.1038/s41586-023-05874-3  0.441
2020 Zecchin D, Moore C, Michailidis F, Horswell S, Rana S, Howell M, Downward J. Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer. Embo Molecular Medicine. e11987. PMID 32672423 DOI: 10.15252/Emmm.202011987  0.434
2020 Rodríguez-Martínez M, Boissiére T, Gonzalez MN, Litchfield K, Mitter R, Walker J, Kjœr S, Ismail M, Downward J, Swanton C, Svejstrup JQ. Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver. Cell. 181: 1395-1405.e11. PMID 32531245 DOI: 10.1016/J.Cell.2020.04.014  0.342
2020 Wamaitha SE, Grybel KJ, Alanis-Lobato G, Gerri C, Ogushi S, McCarthy A, Mahadevaiah SK, Healy L, Lea RA, Molina-Arcas M, Devito LG, Elder K, Snell P, Christie L, Downward J, et al. IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche. Nature Communications. 11: 764. PMID 32034154 DOI: 10.1038/S41467-020-14629-X  0.329
2020 Carné Sd, East P, Moore C, Downward J. Abstract B11: RAS orchestrates the increase of interstitial adenosine in lung adenocarcinoma to promote immune evasion Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-B11  0.387
2020 Jones GG, Rio IBD, Sari S, Sekerim A, Young LC, Hartig N, El-Bahrawy MA, Molina-Arcas M, Downward J, Rodriguez-Viciana P. Abstract B26: The SHOC2 phosphatase complex as a therapeutic target for ERK-pathway inhibition in RAS-driven tumors Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-B26  0.44
2020 Baer R, Rosewell I, Hancock D, Molina-Arcas M, Downward J. Abstract B19: New tools to study the role of RAS/CRAF interaction in RAS-driven lung cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-B19  0.442
2019 Molina-Arcas M, Moore C, Rana S, van Maldegem F, Mugarza E, Romero-Clavijo P, Herbert E, Horswell S, Li LS, Janes MR, Hancock DC, Downward J. Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer. Science Translational Medicine. 11. PMID 31534020 DOI: 10.1126/Scitranslmed.Aaw7999  0.412
2019 Lionarons DA, Hancock DC, Rana S, East P, Moore C, Murillo MM, Carvalho J, Spencer-Dene B, Herbert E, Stamp G, Damry D, Calado DP, Rosewell I, Fritsch R, Neubig RR, ... ... Downward J, et al. RAC1 Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. PMID 31257073 DOI: 10.1016/J.Ccell.2019.05.015  0.342
2019 Liu H, Ertay A, Peng P, Li J, Liu D, Xiong H, Zou Y, Qiu H, Hancock D, Yuan X, Huang WC, Ewing RM, Downward J, Wang Y. SGLT1 is required for the survival of triple negative breast cancer cells via potentiation of EGFR activity. Molecular Oncology. PMID 31199048 DOI: 10.1002/1878-0261.12530  0.373
2019 Jones GG, Del Río IB, Sari S, Sekerim A, Young LC, Hartig N, Areso Zubiaur I, El-Bahrawy MA, Hynds RE, Lei W, Molina-Arcas M, Downward J, Rodriguez-Viciana P. SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers. Nature Communications. 10: 2532. PMID 31182717 DOI: 10.1038/S41467-019-10367-X  0.454
2019 Wang Y, Xiong H, Liu D, Hill C, Ertay A, Li J, Zou Y, Miller P, White E, Downward J, Goldin RD, Yuan X, Lu X. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. 1-14. PMID 30782064 DOI: 10.1080/15548627.2019.1569912  0.467
2019 Mugarza E, Maldegem Fv, Sopena ML, Arcas MM, Downward J. Abstract A145: Study of mechanisms of immune evasion of oncogenic KRAS in NSCLC Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A145  0.324
2019 Molina-Arcas M, Moore C, Rana S, Maldegem FV, Mugarza E, Romero-Clavijo P, Horswell S, Hancock D, Downward J. Abstract B073: Development of combination therapies to potentiate the impact of KRAS-G12C inhibitors in lung cancer Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-B073  0.416
2018 Murillo MM, Rana S, Spencer-Dene B, Nye E, Stamp G, Downward J. Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer. Cell Reports. 25: 3545-3553.e2. PMID 30590030 DOI: 10.1016/J.Celrep.2018.12.003  0.458
2018 Tsolakos N, Durrant TN, Chessa T, Suire SM, Oxley D, Kulkarni S, Downward J, Perisic O, Williams RL, Stephens L, Hawkins PT. Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 30442661 DOI: 10.1073/Pnas.1803446115  0.363
2018 Yao L, Conforti F, Hill C, Bell J, Drawater L, Li J, Liu D, Xiong H, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Coldwell M, Yuan X, ... ... Downward J, et al. Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis. Cell Death and Differentiation. PMID 30050057 DOI: 10.1038/S41418-018-0175-7  0.358
2018 Soutar MPM, Kempthorne L, Miyakawa S, Annuario E, Melandri D, Harley J, O'Sullivan GA, Wray S, Hancock DC, Cookson MR, Downward J, Carlton M, Plun-Favreau H. AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons. Scientific Reports. 8: 8855. PMID 29891871 DOI: 10.1038/S41598-018-26949-6  0.37
2018 Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B, Schulze A. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene. PMID 29872221 DOI: 10.1038/S41388-018-0315-Z  0.323
2018 Molina-Arcas M, Moore C, Rana S, Maldegem Fv, Horswell S, Hancock D, Downward J. Abstract 2987: Identification of new combination therapies for lung tumors harboring KRAS mutations Cancer Research. 78: 2987-2987. DOI: 10.1158/1538-7445.Am2018-2987  0.414
2018 Ismail MS, Downward J. Abstract LB-A17: Identification and Characterization of Cyclic Peptide Inhibitors for Ras/PI3K and Ras/Raf Protein Complexes Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Lb-A17  0.406
2018 Li H, Stokes WB, Chater E, Rupniewska E, Roy R, Mauri FA, Liu X, Kaliszczak M, Downward J, Aboagye E, Tang H, Wang Y, Seckl MJ, Pardo OE. Resistance to tyrosine kinase-targeted therapy in lung cancer: Autophagy and metabolic changes Meta Gene. 17: S10. DOI: 10.1016/J.Mgene.2018.05.044  0.396
2017 Coelho MA, de Carné Trécesson S, Rana S, Zecchin D, Moore C, Molina-Arcas M, East P, Spencer-Dene B, Nye E, Barnouin K, Snijders AP, Lai WS, Blackshear PJ, Downward J. Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA. Immunity. PMID 29246442 DOI: 10.1016/J.Immuni.2017.11.016  0.322
2017 Mancini M, Gal H, Gaborit N, Mazzeo L, Romaniello D, Salame TM, Lindzen M, Mahlknecht G, Enuka Y, Burton DG, Roth L, Noronha A, Marrocco I, Adreka D, Altstadter RE, ... ... Downward J, et al. An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors. Embo Molecular Medicine. PMID 29212784 DOI: 10.15252/Emmm.201708076  0.561
2016 Mathew G, Hannan A, Hertzler-Schaefer K, Wang F, Feng GS, Zhong J, Zhao JJ, Downward J, Zhang X. Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799550 DOI: 10.1073/Pnas.1604450113  0.443
2016 Li H, Stokes W, Chater E, Roy R, de Bruin E, Hu Y, Liu Z, Smit EF, Heynen GJ, Downward J, Seckl MJ, Wang Y, Tang H, Pardo OE. Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer. Cell Discovery. 2: 16031. PMID 27721983 DOI: 10.1038/Celldisc.2016.31  0.342
2016 Houslay DM, Anderson KE, Chessa T, Kulkarni S, Fritsch R, Downward J, Backer JM, Stephens LR, Hawkins PT. Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells. Science Signaling. 9: ra82. PMID 27531651 DOI: 10.1126/Scisignal.Aae0453  0.408
2016 Castellano E, Molina-Arcas M, Krygowska AA, East P, Warne P, Nicol A, Downward J. RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression. Nature Communications. 7: 11245. PMID 27071537 DOI: 10.1038/Ncomms11245  0.477
2016 Pardo OE, Arcaro A, Salerno G, Raguz S, Downward J, Seckl MJ. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway. Correlation with resistance to etoposide-induced apoptosis. The Journal of Biological Chemistry. 290: 15390. PMID 26092981 DOI: 10.1074/Jbc.A115.109006  0.452
2016 Pender A, Rana S, Garcia-Murillas I, Cutts R, Gonzalez D, O'Brien M, Bhosle J, Turner NC, Popat S, Downward J. Simultaneous EGFR mutation detection and copy number assessment in circulating tumour DNA (ctDNA) to inform molecular methods of therapy resistance and plasma ctDNA content in lung adenocarcinoma. Journal of Clinical Oncology. 34. DOI: 10.1200/Jco.2016.34.15_Suppl.E23027  0.314
2015 Godin-Heymann N, Brabetz S, Murillo MM, Saponaro M, Santos CR, Lobley A, East P, Chakravarty P, Matthews N, Kelly G, Jordan S, Castellano E, Downward J. Tumour-suppression function of KLF12 through regulation of anoikis. Oncogene. PMID 26455320 DOI: 10.1038/Onc.2015.394  0.37
2015 Mancini M, Gaborit N, Lindzen M, Salame TM, Dall'Ora M, Sevilla-Sharon M, Abdul-Hai A, Downward J, Yarden Y. Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer. Science Signaling. 8: ra53. PMID 26038598 DOI: 10.1126/Scisignal.Aaa0725  0.587
2015 Downward J. RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1802-9. PMID 25878361 DOI: 10.1158/1078-0432.Ccr-14-2180  0.412
2015 Smith D, Armenteros E, Percy L, Kumar M, Lach A, Herledan G, Stubbs M, Downward J, Yong K. RAS mutation status and bortezomib therapy for relapsed multiple myeloma. British Journal of Haematology. 169: 905-8. PMID 25580780 DOI: 10.1111/Bjh.13258  0.312
2014 Wang Y, Bu F, Royer C, Serres S, Larkin JR, Soto MS, Sibson NR, Salter V, Fritzsche F, Turnquist C, Koch S, Zak J, Zhong S, Wu G, Liang A, ... ... Downward J, et al. ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1. Nature Cell Biology. 16: 1092-104. PMID 25344754 DOI: 10.1038/Ncb3050  0.323
2014 Murillo MM, Zelenay S, Nye E, Castellano E, Lassailly F, Stamp G, Downward J. RAS interaction with PI3K p110α is required for tumor-induced angiogenesis. The Journal of Clinical Investigation. 124: 3601-11. PMID 25003191 DOI: 10.1172/Jci74134  0.34
2014 Endesfelder D, Burrell RA, Kanu N, McGranahan N, Howell M, Parker PJ, Downward J, Swanton C, Kschischo M. Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer. Cancer Research. 74: 4853-63. PMID 24970479 DOI: 10.1158/0008-5472.Can-13-2664  0.308
2014 de Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gómez-Román J, García-Castaño A, Gong Y, Ladanyi M, ... ... Downward J, et al. Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer Discovery. 4: 606-19. PMID 24535670 DOI: 10.1158/2159-8290.Cd-13-0741  0.399
2014 Downward J. RAS's cloak of invincibility slips at last? Cancer Cell. 25: 5-6. PMID 24434204 DOI: 10.1016/J.Ccr.2013.12.016  0.371
2014 Kumar MS, Armenteros-Monterroso E, East P, Chakravorty P, Matthews N, Winslow MM, Downward J. HMGA2 functions as a competing endogenous RNA to promote lung cancer progression. Nature. 505: 212-7. PMID 24305048 DOI: 10.1038/Nature12785  0.331
2014 Linch M, Sanz-Garcia M, Rosse C, Riou P, Peel N, Madsen CD, Sahai E, Downward J, Khwaja A, Dillon C, Roffey J, Cameron AJ, Parker PJ. Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis. 35: 396-406. PMID 24072773 DOI: 10.1093/Carcin/Bgt313  0.408
2013 Sheridan C, Downward J. Inhibiting the RAS-PI3K Pathway in Cancer Therapy Enzymes. 34: 107-136. PMID 25034102 DOI: 10.1016/B978-0-12-420146-0.00005-6  0.451
2013 Castellano E, Sheridan C, Thin MZ, Nye E, Spencer-Dene B, Diefenbacher ME, Moore C, Kumar MS, Murillo MM, Grönroos E, Lassailly F, Stamp G, Downward J. Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance Cancer Cell. 24: 617-630. PMID 24229709 DOI: 10.1016/J.Ccr.2013.09.012  0.414
2013 Fritsch R, de Krijger I, Fritsch K, George R, Reason B, Kumar MS, Diefenbacher M, Stamp G, Downward J. RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell. 153: 1050-63. PMID 23706742 DOI: 10.1016/J.Cell.2013.04.031  0.473
2013 Weigelt B, Warne PH, Lambros MB, Reis-Filho JS, Downward J. PI3K pathway dependencies in endometrioid endometrial cancer cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3533-44. PMID 23674493 DOI: 10.1158/1078-0432.Ccr-12-3815  0.416
2013 Molina-Arcas M, Hancock DC, Sheridan C, Kumar MS, Downward J. Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS -mutant lung cancer Cancer Discovery. 3: 548-563. PMID 23454899 DOI: 10.1158/2159-8290.Cd-12-0446  0.461
2013 Sheridan C, Castellano E, Thin MZ, Murillo M, Lassailly F, Stamp G, Downward J. Abstract A54: Requirement for interaction of PI 3-kinase p110alpha with Ras in lung tumor maintenance Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-A54  0.428
2013 Downward J. Abstract SY25-02: Synthetic lethal approaches to targeting RAS mutant tumors: Is there an Achilles' heel. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy25-02  0.454
2013 Weigelt B, Warne PH, Lambros MB, Reis-Filho JS, Downward J. Abstract 4472: PI3K pathway dependencies in endometrioid endometrial cancer. Cancer Research. 73: 4472-4472. DOI: 10.1158/1538-7445.Am2013-4472  0.428
2013 Downward J. Abstract PL04-04: Synthetic lethal approaches to targeting Ras mutant cancers. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Pl04-04  0.465
2013 Kumar MS, Armenteros-Monterroso E, East P, Chakravorty P, Matthews N, Winslow MM, Downward J. Abstract B221: Hmga2 furthers lung adenocarcinoma progression through function as a competing endogenous RNA. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B221  0.339
2013 Kumar MS, Downward J. Abstract PR14: Targeting the GATA2 transcriptional network in K-Ras driven lung adenocarcinoma Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr14  0.37
2012 Weigelt B, Downward J. Genomic Determinants of PI3K Pathway Inhibitor Response in Cancer. Frontiers in Oncology. 2: 109. PMID 22970424 DOI: 10.3389/Fonc.2012.00109  0.378
2012 Bögel G, Gujdár A, Geiszt M, Lányi Á, Fekete A, Sipeki S, Downward J, Buday L. Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration. The Journal of Biological Chemistry. 287: 31321-9. PMID 22829589 DOI: 10.1074/Jbc.M111.324897  0.453
2012 Steckel M, Molina-Arcas M, Weigelt B, Marani M, Warne PH, Kuznetsov H, Kelly G, Saunders B, Howell M, Downward J, Hancock DC. Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies. Cell Research. 22: 1227-45. PMID 22613949 DOI: 10.1038/Cr.2012.82  0.392
2012 Kumar MS, Hancock DC, Molina-Arcas M, Steckel M, East P, Diefenbacher M, Armenteros-Monterroso E, Lassailly F, Matthews N, Nye E, Stamp G, Behrens A, Downward J. The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell. 149: 642-55. PMID 22541434 DOI: 10.1016/J.Cell.2012.02.059  0.454
2012 Molina-Arcas M, Downward J. How to fool a wonder drug: truncate and dimerize. Cancer Cell. 21: 7-9. PMID 22264784 DOI: 10.1016/J.Ccr.2011.12.017  0.331
2012 Schulze A, Downward J. Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells. Molecular Cell. 44: 846-8. PMID 22195959 DOI: 10.1016/J.Molcel.2011.12.004  0.387
2012 Cully M, Downward J. Assessing cell size and cell cycle regulation in cells with altered TOR activity. Methods in Molecular Biology (Clifton, N.J.). 821: 227-37. PMID 22125068 DOI: 10.1007/978-1-61779-430-8_13  0.342
2012 Lee AJ, Roylance R, Sander J, Gorman P, Endesfelder D, Kschischo M, Jones NP, East P, Nicke B, Spassieva S, Obeid LM, Birkbak NJ, Szallasi Z, McKnight NC, Rowan AJ, ... ... Downward J, et al. CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction. The Journal of Pathology. 226: 482-94. PMID 21953249 DOI: 10.1002/Path.2998  0.335
2012 Downward J. Abstract IA12: Targeting unique dependencies of RAS mutant tumors. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-Ia12  0.444
2012 Gerlinger M, Rowan A, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald N, Butler A, ... ... Downward J, et al. Abstract 964: Intra-tumor heterogeneity and Darwinian selection revealed by multi-region exome sequencing of renal cell carcinomas Cancer Research. 72: 964-964. DOI: 10.1158/1538-7445.Am2012-964  0.303
2012 Weigelt B, Warne PH, Lambros M, Reis-Filho JS, Downward J. Abstract 4835: Genetic determinants of mTOR inhibitor response in breast and endometrial cancer Cancer Research. 72: 4835-4835. DOI: 10.1158/1538-7445.Am2012-4835  0.393
2012 Molina-Arcas M, Hancock D, Steckel M, Downward J. Abstract 4163: Determination of synthetic lethal interactions in KRAS oncogene dependent cancer cells reveals novel therapeutic targeting strategies Cancer Research. 72: 4163-4163. DOI: 10.1158/1538-7445.Am2012-4163  0.472
2012 Cowell CF, De Bruin EC, Howell M, Downward J. Abstract A17: Loss of DEPTOR increases resistance to EGFR tyrosine kinase inhibitors by upregulating EGFR and MAPK signaling Clinical Cancer Research. 18: A17-A17. DOI: 10.1158/1078-0432.Mechres-A17  0.414
2012 Kumar MS, Downward J. Abstract A26: GATA2 is necessary for oncogene-mutant non-small cell lung tumorigenesis Clinical Cancer Research. 18: A26-A26. DOI: 10.1158/1078-0432.12Aacriaslc-A26  0.409
2012 Molina Arcas M, Hancock D, Steckel M, Downward J. 374 Determination of Synthetic Lethal Interactions in KRAS Oncogene Dependent Cancer Cells Reveals Novel Therapeutic Targeting Strategies European Journal of Cancer. 48: S90-S91. DOI: 10.1016/S0959-8049(12)71060-2  0.332
2012 Zeller KS, Idevall-Hagren O, Stefansson A, Velling T, Jackson SP, Downward J, Tengholm A, Johansson S. Corrigendum to “PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading” [Cell. Signal. 22 (2010) 1838–1848] Cellular Signalling. 24: 971-972. DOI: 10.1016/J.Cellsig.2011.12.010  0.39
2011 Castellano E, Downward J. RAS Interaction with PI3K: More Than Just Another Effector Pathway. Genes & Cancer. 2: 261-74. PMID 21779497 DOI: 10.1177/1947601911408079  0.461
2011 Lara R, Mauri FA, Taylor H, Derua R, Shia A, Gray C, Nicols A, Shiner RJ, Schofield E, Bates PA, Waelkens E, Dallman M, Lamb J, Zicha D, Downward J, et al. An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis. Oncogene. 30: 3513-21. PMID 21423205 DOI: 10.1038/Onc.2011.61  0.363
2011 Downward J. Targeting RAF: trials and tribulations. Nature Medicine. 17: 286-8. PMID 21383738 DOI: 10.1038/Nm0311-286  0.34
2011 Lee AJ, Endesfelder D, Rowan AJ, Walther A, Birkbak NJ, Futreal PA, Downward J, Szallasi Z, Tomlinson IP, Howell M, Kschischo M, Swanton C. Chromosomal instability confers intrinsic multidrug resistance. Cancer Research. 71: 1858-70. PMID 21363922 DOI: 10.1158/0008-5472.Can-10-3604  0.337
2011 Weigelt B, Warne PH, Downward J. PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs. Oncogene. 30: 3222-33. PMID 21358673 DOI: 10.1038/Onc.2011.42  0.416
2011 Castellano E, Downward J. Role of RAS in the regulation of PI 3-kinase. Current Topics in Microbiology and Immunology. 346: 143-69. PMID 20563706 DOI: 10.1007/82_2010_56  0.475
2011 Bruin ECd, Cowell CF, Howell M, Varmus HE, Politi K, Downward J. Abstract LB-398: Identification of novel mechanisms of resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-398  0.404
2011 Lara R, Mauri FA, Taylor H, Derua R, Shia A, Gray C, Nicols A, Shiner RJ, Schofield E, Bates PA, Waelkens E, Dallman M, Lamb J, Zicha D, Downward J, et al. Abstract LB-356: An siRNA screen identifies Rsk1 as a key modulator of lung cancer metastasis Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-356  0.369
2011 Murillo MM, Tilley F, Lassailly F, Downward J. Abstract A169: The role of the RAS-PI3K interaction in tumor maintenance and metastasis. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A169  0.386
2010 Vento MT, Zazzu V, Loffreda A, Cross JR, Downward J, Stoppelli MP, Iaccarino I. Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells. Plos One. 5: e15636. PMID 21203533 DOI: 10.1371/Journal.Pone.0015636  0.624
2010 Zeller KS, Idevall-Hagren O, Stefansson A, Velling T, Jackson SP, Downward J, Tengholm A, Johansson S. PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading. Cellular Signalling. 22: 1838-48. PMID 20667469 DOI: 10.1016/J.Cellsig.2010.07.011  0.444
2010 Wang Y, Ngo VN, Marani M, Yang Y, Wright G, Staudt LM, Downward J. Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. Oncogene. 29: 4658-70. PMID 20562906 DOI: 10.1038/Onc.2010.218  0.414
2010 Alfano D, Votta G, Schulze A, Downward J, Caputi M, Stoppelli MP, Iaccarino I. Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor. Molecular and Cellular Biology. 30: 1838-51. PMID 20123981 DOI: 10.1128/Mcb.01442-09  0.361
2010 Cully M, Genevet A, Warne P, Treins C, Liu T, Bastien J, Baum B, Tapon N, Leevers SJ, Downward J. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Molecular and Cellular Biology. 30: 481-95. PMID 19917724 DOI: 10.1128/Mcb.00688-09  0.414
2010 Treins C, Downward J. 5 - mTORC2: The Other Facet of mTOR The Enzymes. 28: 99-124. DOI: 10.1016/S1874-6047(10)28005-8  0.363
2009 Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J. Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells. Molecular Cancer. 8: 131. PMID 20042122 DOI: 10.1186/1476-4598-8-131  0.439
2009 Treins C, Warne PH, Magnuson MA, Pende M, Downward J. Rictor is a novel target of p70 S6 kinase-1. Oncogene. 29: 1003-16. PMID 19935711 DOI: 10.1038/Onc.2009.401  0.409
2009 Downward J. Cancer: A tumour gene's fatal flaws. Nature. 462: 44-5. PMID 19890318 DOI: 10.1038/462044A  0.351
2009 Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, ... ... Downward J, et al. Chromosomal instability determines taxane response. Proceedings of the National Academy of Sciences of the United States of America. 106: 8671-6. PMID 19458043 DOI: 10.1073/Pnas.0811835106  0.311
2009 Downward J, Hahn WC. Genetic and cellular mechanisms of oncogenesis Current Opinion in Genetics and Development. 19: 1-3. PMID 19208465 DOI: 10.1016/J.Gde.2009.01.001  0.415
2009 Burrell RA, McClelland SE, Juul NS, Downward J, Szallasi ZI, Swanton C. Regulators of Mitotic Transition Determine Paclitaxel Resistance In Vitro and Predict Poor Prognosis in Breast Cancer In Vivo. Cancer Research. 69: 2151-2151. DOI: 10.1158/0008-5472.Sabcs-09-2151  0.353
2009 Juul NS, Eklund AC, Li Q, Downward J, Burrell R, Szallasi ZI, Swanton C. A Functional Metagene Incorporating TTK Protein Kinase, Aurora Kinase B and Glucosylceramide Synthase Predicts Response to Treatment in Primary Breast Cancer Cancer Research. 69: 2032-2032. DOI: 10.1158/0008-5472.Sabcs-09-2032  0.324
2008 Downward J. Targeting RAS and PI3K in lung cancer. Nature Medicine. 14: 1315-6. PMID 19057554 DOI: 10.1038/Nm1208-1315  0.458
2008 Swanton C, Szallasi Z, Brenton JD, Downward J. Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer. Breast Cancer Research : Bcr. 10: 214. PMID 18986507 DOI: 10.1186/Bcr2159  0.305
2008 Cully M, Downward J. SnapShot: Ras Signaling. Cell. 133: 1292-1292.e1. PMID 18585361 DOI: 10.1016/J.Cell.2008.06.020  0.453
2008 Buday L, Downward J. Many faces of Ras activation. Biochimica Et Biophysica Acta. 1786: 178-87. PMID 18541156 DOI: 10.1016/J.Bbcan.2008.05.001  0.414
2008 Cross JR, Postigo A, Blight K, Downward J. Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur. Cell Death and Differentiation. 15: 997-1008. PMID 18274554 DOI: 10.1038/Cdd.2008.14  0.602
2008 Swanton C, Downward J. Unraveling the complexity of endocrine resistance in breast cancer by functional genomics. Cancer Cell. 13: 83-5. PMID 18242507 DOI: 10.1016/J.Ccr.2008.01.021  0.328
2007 Ahmed AA, Mills AD, Ibrahim AE, Temple J, Blenkiron C, Vias M, Massie CE, Iyer NG, McGeoch A, Crawford R, Nicke B, Downward J, Swanton C, Bell SD, Earl HM, et al. The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell. 12: 514-27. PMID 18068629 DOI: 10.1016/J.Ccr.2007.11.014  0.342
2007 Ramjaun AR, Downward J. Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis. Cell Cycle (Georgetown, Tex.). 6: 2902-5. PMID 17993782 DOI: 10.4161/Cc.6.23.4996  0.454
2007 Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nature Cell Biology. 9: 1243-52. PMID 17906618 DOI: 10.1038/Ncb1644  0.337
2007 Wells V, Downward J, Mallucci L. Functional inhibition of PI3K by the βGBP molecule suppresses Ras-MAPK signalling to block cell proliferation Oncogene. 26: 7709-7714. PMID 17603562 DOI: 10.1038/Sj.Onc.1210580  0.478
2007 Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell. 11: 498-512. PMID 17560332 DOI: 10.1016/J.Ccr.2007.04.011  0.322
2007 Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J. Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell. 129: 957-68. PMID 17540175 DOI: 10.1016/J.Cell.2007.03.051  0.448
2007 Delpuech O, Griffiths B, East P, Essafi A, Lam EW, Burgering B, Downward J, Schulze A. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Molecular and Cellular Biology. 27: 4917-30. PMID 17452451 DOI: 10.1128/Mcb.01789-06  0.413
2007 Calleja V, Alcor D, Laguerre M, Park J, Vojnovic B, Hemmings BA, Downward J, Parker PJ, Larijani B. Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. Plos Biology. 5: e95. PMID 17407381 DOI: 10.1371/Journal.Pbio.0050095  0.391
2007 Buday L, Downward J. Roles of cortactin in tumor pathogenesis. Biochimica Et Biophysica Acta. 1775: 263-73. PMID 17292556 DOI: 10.1016/J.Bbcan.2006.12.002  0.372
2007 Ripka S, König A, Buchholz M, Wagner M, Sipos B, Klöppel G, Downward J, Gress TM, Michl P. WNT5A - Target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer Carcinogenesis. 28: 1178-1187. PMID 17227781 DOI: 10.1093/Carcin/Bgl255  0.312
2007 Ramjaun AR, Tomlinson S, Eddaoudi A, Downward J. Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. Oncogene. 26: 970-81. PMID 16909112 DOI: 10.1038/Sj.Onc.1209852  0.347
2006 Downward J. Signal transduction. Prelude to an anniversary for the RAS oncogene. Science (New York, N.Y.). 314: 433-4. PMID 17053139 DOI: 10.1126/Science.1134727  0.381
2006 Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, et al. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods. 3: 777-9. PMID 16990807 DOI: 10.1038/Nmeth1006-777  0.408
2006 Pardo OE, Wellbrock C, Khanzada UK, Aubert M, Arozarena I, Davidson S, Bowen F, Parker PJ, Filonenko VV, Gout IT, Sebire N, Marais R, Downward J, Seckl MJ. FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. The Embo Journal. 25: 3078-88. PMID 16810323 DOI: 10.1038/Sj.Emboj.7601198  0.41
2006 Katso RM, Pardo OE, Palamidessi A, Franz CM, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley AJ, Waterfield MD, Arcaro A. Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Molecular Biology of the Cell. 17: 3729-44. PMID 16775008 DOI: 10.1091/Mbc.E05-11-1083  0.619
2006 Janda E, Nevolo M, Lehmann K, Downward J, Beug H, Grieco M. Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene. 25: 7117-30. PMID 16751808 DOI: 10.1038/Sj.Onc.1209701  0.329
2006 Swanton C, Tomlinson I, Downward J. Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle (Georgetown, Tex.). 5: 818-23. PMID 16628000 DOI: 10.4161/Cc.5.8.2682  0.301
2006 Jansson AL, Yasmin L, Warne P, Downward J, Palmer RH, Hallberg B. Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt. Cellular Microbiology. 8: 815-22. PMID 16611230 DOI: 10.1111/J.1462-5822.2005.00668.X  0.453
2006 Michl P, Knobel B, Downward J. CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility. The Journal of Biological Chemistry. 281: 15138-44. PMID 16574653 DOI: 10.1074/Jbc.M600908200  0.422
2006 Shin SY, Bahk YY, Ko J, Chung IY, Lee YS, Downward J, Eibel H, Sharma PM, Olefsky JM, Kim YH, Lee B, Lee YH. Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. The Embo Journal. 25: 1093-103. PMID 16456537 DOI: 10.1038/Sj.Emboj.7600987  0.434
2006 Postigo A, Cross JR, Downward J, Way M. Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis Cell Death and Differentiation. 13: 1651-1662. PMID 16439990 DOI: 10.1038/Sj.Cdd.4401853  0.6
2006 Michl P, Downward J. CUTL1: a key mediator of TGFbeta-induced tumor invasion. Cell Cycle (Georgetown, Tex.). 5: 132-4. PMID 16357536 DOI: 10.4161/Cc.5.2.2311  0.362
2006 Khanzada UK, Pardo OE, Meier C, Downward J, Seckl MJ, Arcaro A. Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling. Oncogene. 25: 877-87. PMID 16170339 DOI: 10.1038/Sj.Onc.1209117  0.475
2005 Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, et al. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Molecular Cell. 20: 673-85. PMID 16337592 DOI: 10.1016/J.Molcel.2005.10.038  0.485
2005 Michl P, Downward J. Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers. Zeitschrift Fur Gastroenterologie. 43: 1133-9. PMID 16220453 DOI: 10.1055/S-2005-858638  0.453
2005 Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, Schulze A. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene. 24: 6465-81. PMID 16007182 DOI: 10.1038/Sj.Onc.1208802  0.352
2005 Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R, D'Arrigo C, Ryder K, Menke A, Gress T, Downward J. CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell. 7: 521-32. PMID 15950902 DOI: 10.1016/J.Ccr.2005.05.018  0.356
2005 Baksh S, Tommasi S, Fenton S, Yu VC, Martins LM, Pfeifer GP, Latif F, Downward J, Neel BG. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to bax conformational change and cell death Molecular Cell. 18: 637-650. PMID 15949439 DOI: 10.1016/J.Molcel.2005.05.010  0.309
2005 Stoll V, Calleja V, Vassaux G, Downward J, Lemoine NR. Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer Gut. 54: 109-116. PMID 15591514 DOI: 10.1136/Gut.2004.046706  0.439
2005 Downward J. Ras regulation: putting back the GTP. Current Biology : Cb. 2: 329-31. PMID 15335949 DOI: 10.1016/0960-9822(92)90897-J  0.401
2004 Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, ... ... Downward J, et al. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Molecular and Cellular Biology. 24: 9848-62. PMID 15509788 DOI: 10.1128/Mcb.24.22.9848-9862.2004  0.335
2004 Downward J. PI 3-kinase, Akt and cell survival. Seminars in Cell & Developmental Biology. 15: 177-82. PMID 15209377 DOI: 10.1016/J.Semcdb.2004.01.002  0.464
2004 Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F. RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics. Cancer Research. 64: 4112-6. PMID 15205320 DOI: 10.1158/0008-5472.Can-04-0267  0.331
2004 Schulze A, Nicke B, Warne PH, Tomlinson S, Downward J. The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component. Molecular Biology of the Cell. 15: 3450-63. PMID 15090615 DOI: 10.1091/Mbc.E03-11-0807  0.47
2004 Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F. Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. Cancer Research. 64: 102-7. PMID 14729613 DOI: 10.1158/0008-5472.Can-03-2622  0.367
2004 Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR. Role of Bim in the survival pathway induced by Raf in epithelial cells Oncogene. 23: 2431-2441. PMID 14676826 DOI: 10.1038/Sj.Onc.1207364  0.459
2004 Downward J. Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways? The Biochemical Journal. 376: e9-10. PMID 14656216 DOI: 10.1042/Bj20031745  0.425
2004 Downward J. Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells Oncogene. 23: 8376-8383. DOI: 10.1038/Sj.Onc.1208073  0.312
2003 Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD, Lemoine NR, Mehmet H, Seckl MJ, Downward J. Fibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells Molecular and Cellular Biology. 23: 7600-7610. PMID 14560006 DOI: 10.1128/Mcb.23.21.7600-7610.2003  0.395
2003 Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. The Journal of Biological Chemistry. 278: 49417-27. PMID 14512424 DOI: 10.1074/Jbc.M308659200  0.347
2003 Calleja V, Ameer-Beg SM, Vojnovic B, Woscholski R, Downward J, Larijani B. Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy. The Biochemical Journal. 372: 33-40. PMID 12662152 DOI: 10.1042/Bj20030358  0.332
2003 Basu S, Totty NF, Irwin MS, Sudol M, Downward J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Molecular Cell. 11: 11-23. PMID 12535517 DOI: 10.1016/S1097-2765(02)00776-1  0.407
2003 Downward J. Targeting RAS signalling pathways in cancer therapy. Nature Reviews. Cancer. 3: 11-22. PMID 12509763 DOI: 10.1038/Nrc969  0.418
2003 Tamás P, Solti Z, Bauer P, Illés A, Sipeki S, Bauer A, Faragó A, Downward J, Buday L. Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. The Journal of Biological Chemistry. 278: 5163-71. PMID 12454019 DOI: 10.1074/Jbc.M207555200  0.463
2003 Khanna S, Warnasuriya GD, Downward J, Naaby-Hansen S. RNAi and 2DE, a promising combination for analysis of phospho-signalling and substrate identification Letters in Peptide Science. 10: 437-445. DOI: 10.1007/S10989-004-3533-X  0.443
2002 Nicolás FJ, Lehmann K, Warne PH, Hill CS, Downward J. Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest. The Journal of Biological Chemistry. 278: 3251-6. PMID 12435725 DOI: 10.1074/Jbc.M209019200  0.312
2002 Vyas S, Béchade C, Riveau B, Downward J, Triller A. Involvement of survival motor neuron (SMN) protein in cell death. Human Molecular Genetics. 11: 2751-64. PMID 12374765 DOI: 10.1093/Hmg/11.22.2751  0.34
2002 Cowling V, Downward J. Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain. Cell Death and Differentiation. 9: 1046-56. PMID 12232792 DOI: 10.1038/Sj.Cdd.4401065  0.303
2002 Janda E, Litos G, Grünert S, Downward J, Beug H. Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway. Oncogene. 21: 5148-59. PMID 12140765 DOI: 10.1038/Sj.Onc.1205661  0.44
2002 Edme N, Downward J, Thiery JP, Boyer B. Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways. Journal of Cell Science. 115: 2591-601. PMID 12045229 DOI: 10.1242/jcs.115.12.2591  0.339
2002 Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Molecular and Cellular Biology. 22: 3577-89. PMID 11997495 DOI: 10.1128/Mcb.22.11.3577-3589.2002  0.344
2002 Reynolds LF, Smyth LA, Norton T, Freshney N, Downward J, Kioussis D, Tybulewicz VL. Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. The Journal of Experimental Medicine. 195: 1103-14. PMID 11994416 DOI: 10.1084/Jem.20011663  0.398
2002 Pardo OE, Arcaro A, Salerno G, Raguz S, Downward J, Seckl MJ. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis. The Journal of Biological Chemistry. 277: 12040-6. PMID 11815602 DOI: 10.1074/jbc.M109006200  0.341
2002 Inabe K, Ishiai M, Scharenberg AM, Freshney N, Downward J, Kurosaki T. Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. The Journal of Experimental Medicine. 195: 189-200. PMID 11805146 DOI: 10.1084/Jem.20011571  0.425
2002 Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, Beug H, Grünert S. Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. The Journal of Cell Biology. 156: 299-313. PMID 11790801 DOI: 10.1083/Jcb.200109037  0.459
2002 Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C, Downward J. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. The Journal of Biological Chemistry. 277: 439-44. PMID 11602612 DOI: 10.1074/Jbc.M109784200  0.342
2001 Scibetta AG, Albanese I, Morris J, Cooper L, Downward J, Rowe PP, Taylor-Papadimitriou J. Regulation of MUC1 expression in human mammary cell lines by the c-ErbB2 and ras signaling pathways. Dna and Cell Biology. 20: 265-74. PMID 11410163 DOI: 10.1089/104454901750232463  0.433
2001 Rodriguez-Viciana P, Downward J. Ras activation of phosphatidylinositol 3-kinase and Akt. Methods in Enzymology. 333: 37-44. PMID 11400352 DOI: 10.1016/S0076-6879(01)33042-2  0.429
2001 Schulze A, Lehmann K, Jefferies HBJ, McMahon M, Downward J. Analysis of the transcriptional program induced by Raf in epithelial cells Genes & Development. 15: 981-994. PMID 11316792 DOI: 10.1101/Gad.191101  0.445
2001 Berrier AL, Mastrangelo AM, Downward J, Ginsberg M, LaFlamme SE. Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains. The Journal of Cell Biology. 151: 1549-60. PMID 11134082 DOI: 10.1083/Jcb.151.7.1549  0.439
2001 Downward J, Leevers SJ. Trachealess—A New Transcription Factor Target for PKB/Akt Developmental Cell. 1: 726-728. DOI: 10.1016/S1534-5807(01)00099-5  0.336
2001 Rubio I, Downward J. Ras activation revisited Signal Transduction. 1: 11-24. DOI: 10.1002/1615-4061(200101)1:1+<11::Aid-Sita11>3.0.Co;2-J  0.378
2000 Oertli B, Han J, Marte BM, Sethi T, Downward J, Ginsberg M, Hughes PE. The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function Oncogene. 19: 4961-4969. PMID 11042683 DOI: 10.1038/Sj.Onc.1203876  0.397
2000 Lehmann K, Janda E, Pierreux CE, Rytömaa M, Schulze A, McMahon M, Hill CS, Beug H, Downward J. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes & Development. 14: 2610-2622. PMID 11040215 DOI: 10.1101/Gad.181700  0.456
2000 Rytömaa M, Lehmann K, Downward J. Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene. 19: 4461-8. PMID 11002418 DOI: 10.1038/Sj.Onc.1203805  0.379
2000 Odajima J, Matsumura I, Sonoyama J, Daino H, Kawasaki A, Tanaka H, Inohara N, Kitamura T, Downward J, Nakajima K, Hirano T, Kanakura Y. Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival. The Journal of Biological Chemistry. 275: 24096-105. PMID 10918073 DOI: 10.1074/Jbc.M001606200  0.462
2000 Kinashi T, Katagiri K, Watanabe S, Vanhaesebroeck B, Downward J, Takatsu K. Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras. The Journal of Biological Chemistry. 275: 22590-6. PMID 10801791 DOI: 10.1074/Jbc.M000633200  0.42
2000 Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R. Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma. European Journal of Biochemistry. 266: 70-82. PMID 10542052 DOI: 10.1046/J.1432-1327.1999.00815.X  0.402
2000 Rytömaa M, Martins LM, Downward J. Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis. Current Biology : Cb. 9: 1043-6. PMID 10508619 DOI: 10.1016/S0960-9822(99)80454-0  0.39
2000 Clissi B, D’Ambrosio D, Geginat J, Colantonio L, Morrot A, Freshney NW, Downward J, Sinigaglia F, Pardi R. Chemokines Fail to Up-Regulate β1Integrin-Dependent Adhesion in Human Th2 T Lymphocytes The Journal of Immunology. 164: 3292-3300. DOI: 10.4049/Jimmunol.164.6.3292  0.358
1999 Downward J. How BAD phosphorylation is good for survival. Nature Cell Biology. 1: E33-5. PMID 10559890 DOI: 10.1038/10026  0.353
1999 Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. The Journal of Biological Chemistry. 274: 32274-8. PMID 10542266 DOI: 10.1074/Jbc.274.45.32274  0.423
1999 Ashcroft M, Stephens RM, Hallberg B, Downward J, Kaplan DR. The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth Oncogene. 18: 4586-4597. PMID 10467403 DOI: 10.1038/Sj.Onc.1202814  0.433
1999 Gille H, Downward J. Multiple ras effector pathways contribute to G(1) cell cycle progression. The Journal of Biological Chemistry. 274: 22033-40. PMID 10419529 DOI: 10.1074/Jbc.274.31.22033  0.461
1999 Wunderlich L, Gohér A, Faragó A, Downward J, Buday L. Requirement of multiple SH3 domains of Nck for ligand binding. Cellular Signalling. 11: 253-62. PMID 10372803 DOI: 10.1016/S0898-6568(98)00054-0  0.335
1999 Sethi T, Ginsberg MH, Downward J, Hughes PE. The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway Molecular Biology of the Cell. 10: 1799-1809. PMID 10359597 DOI: 10.1091/Mbc.10.6.1799  0.402
1999 Wennström S, Downward J. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor. Molecular and Cellular Biology. 19: 4279-88. PMID 10330169 DOI: 10.1128/Mcb.19.6.4279  0.472
1999 Wunderlich L, Faragó A, Downward J, Buday L. Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes. European Journal of Immunology. 29: 1068-75. PMID 10229072 DOI: 10.1002/(Sici)1521-4141(199904)29:04<1068::Aid-Immu1068>3.0.Co;2-P  0.385
1999 Watton SJ, Downward J. Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction Current Biology. 9: 433-436. PMID 10226029 DOI: 10.1016/S0960-9822(99)80192-4  0.454
1999 Lockyer PJ, Wennström S, Kupzig S, Venkateswarlu K, Downward J, Cullen PJ. Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo. Current Biology : Cb. 9: 265-8. PMID 10074452 DOI: 10.1016/S0960-9822(99)80116-X  0.359
1999 McNeill H, Downward J. Apoptosis: Ras to the rescue in the fly eye. Current Biology : Cb. 9: R176-9. PMID 10074440 DOI: 10.1016/S0960-9822(99)80107-9  0.373
1999 Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, Albanese C, Downward J, Pestell RG, Kanakura Y. Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. The Embo Journal. 18: 1367-77. PMID 10064602 DOI: 10.1093/Emboj/18.5.1367  0.358
1999 Lockyer PJ, Wennström S, Kupzig S, Venkateswarlu K, Downward J, Cullen PJ. Identification of the Ras GTPase-activating protein GAP1m as an in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein Biochemical Society Transactions. 27: A104-A104. DOI: 10.1042/Bst027A104A  0.371
1998 Downward J. Signal transduction. New exchange, new target. Nature. 396: 416-7. PMID 9853744 DOI: 10.1038/24743  0.368
1998 Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD. Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity Journal of Biological Chemistry. 273: 33082-33090. PMID 9830063 DOI: 10.1074/Jbc.273.49.33082  0.584
1998 Roche S, Downward J, Raynal P, Courtneidge SA. A function for phosphatidylinositol 3-kinase β (p85α-p110β) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction Molecular and Cellular Biology. 18: 7119-7129. PMID 9819398 DOI: 10.1128/Mcb.18.12.7119  0.434
1998 Fuller SJ, Finn SG, Downward J, Sugden PH. Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf Biochemical Journal. 335: 241-246. PMID 9761720 DOI: 10.1042/Bj3350241  0.39
1998 Hallberg B, Ashcroft M, Loeb DM, Kaplan DR, Downward J. Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase Oncogene. 17: 691-697. PMID 9715270 DOI: 10.1038/Sj.Onc.1201980  0.475
1998 Khwaja A, Lehmann K, Marte BM, Downward J. Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway. The Journal of Biological Chemistry. 273: 18793-801. PMID 9668053 DOI: 10.1074/Jbc.273.30.18793  0.449
1998 Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Current Opinion in Cell Biology. 10: 262-267. PMID 9561851 DOI: 10.1016/S0955-0674(98)80149-X  0.436
1998 Downward J. Ras signalling and apoptosis. Current Opinion in Genetics & Development. 8: 49-54. PMID 9529605 DOI: 10.1016/S0959-437X(98)80061-0  0.467
1998 Van Weering DHJ, De Rooij J, Marte B, Downward J, Bos JL, Burgering BMT. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras Molecular and Cellular Biology. 18: 1802-1811. PMID 9528752 DOI: 10.1128/Mcb.18.4.1802  0.478
1998 Downward J. Lipid-regulated kinases: some common themes at last. Science (New York, N.Y.). 279: 673-4. PMID 9471728 DOI: 10.1126/Science.279.5351.673  0.346
1998 Jimenez C, Jones DR, Rodríguez-Viciana P, Gonzalez-García A, Leonardo E, Wennström S, von Kobbe C, Toran JL, R-Borlado L, Calvo V, Copin SG, Albar JP, Gaspar ML, Diez E, Marcos MA, ... Downward J, et al. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. The Embo Journal. 17: 743-53. PMID 9450999 DOI: 10.1093/Emboj/17.3.743  0.42
1998 Denouel-Galy A, Douville EM, Warne PH, Papin C, Laugier D, Calothy G, Downward J, Eychène A. Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Current Biology : Cb. 8: 46-55. PMID 9427625 DOI: 10.1016/S0960-9822(98)70019-3  0.449
1997 Khwaja A, Downward J. Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells. The Journal of Cell Biology. 139: 1017-23. PMID 9362519 DOI: 10.1083/Jcb.139.4.1017  0.445
1997 Downward J. Role of phosphoinositide-3-OH kinase in Ras signaling. Advances in Second Messenger and Phosphoprotein Research. 31: 1-10. PMID 9344237 DOI: 10.1016/S1040-7952(97)80004-3  0.302
1997 Rubio I, Rodriguez-Viciana P, Downward J, Wetzker R. Interaction of Ras with phosphoinositide 3-kinase gamma. The Biochemical Journal. 891-5. PMID 9307042 DOI: 10.1042/Bj3260891  0.426
1997 Marte BM, Downward J. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends in Biochemical Sciences. 22: 355-8. PMID 9301337 DOI: 10.1016/S0968-0004(97)01097-9  0.436
1997 Douville E, Downward J. EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2. Oncogene. 15: 373-83. PMID 9242373 DOI: 10.1038/Sj.Onc.1201214  0.422
1997 Khwaja A, Rodriguez-Viciana P, Wennström S, Warne PH, Downward J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. The Embo Journal. 16: 2783-93. PMID 9184223 DOI: 10.1093/Emboj/16.10.2783  0.479
1997 Downward J. Cell cycle: routine role for Ras. Current Biology : Cb. 7: R258-60. PMID 9162506 DOI: 10.1016/S0960-9822(06)00116-3  0.387
1997 Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell. 89: 457-67. PMID 9150145 DOI: 10.1016/S0092-8674(00)80226-3  0.632
1997 Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 94: 4330-5. PMID 9113989 DOI: 10.1073/Pnas.94.9.4330  0.622
1997 Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, Evan G. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB Nature. 385: 544-548. PMID 9020362 DOI: 10.1038/385544A0  0.453
1997 Marte BM, Rodriguez-Viciana P, Wennström S, Warne PH, Downward J. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways. Current Biology : Cb. 7: 63-70. PMID 8999998 DOI: 10.1016/S0960-9822(06)00028-5  0.398
1996 Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. The Embo Journal. 15: 2442-51. PMID 8665852 DOI: 10.1002/J.1460-2075.1996.Tb00602.X  0.635
1996 Rodriguez-Viciana P, Marte BM, Warne PH, Downward J. Phosphatidylinositol 3' kinase: one of the effectors of Ras. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 225-31; discussion 2. PMID 8650270 DOI: 10.1098/RSTB.1996.0020  0.354
1996 Buday L, Khwaja A, Sipeki S, Faragó A, Downward J. Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation. The Journal of Biological Chemistry. 271: 6159-63. PMID 8626404 DOI: 10.1074/Jbc.271.11.6159  0.417
1996 Downward J. KSR: a novel player in the RAS pathway. Cell. 83: 831-4. PMID 8521506 DOI: 10.1016/0092-8674(95)90198-1  0.438
1996 Downward J. The Protein Kinase Facts Book (Parts I and II) Immunology Today. 17: 49-50. DOI: 10.1016/0167-5699(96)80572-X  0.334
1995 Wang W, Fisher EM, Jia Q, Dunn JM, Porfiri E, Downward J, Egan SE. The Grb2 binding domain of mSos1 is not required for downstream signal transduction. Nature Genetics. 10: 294-300. PMID 7670467 DOI: 10.1038/Ng0795-294  0.37
1995 Downward J. Signal transduction. A target for PI(3) kinase. Nature. 376: 553-4. PMID 7637799 DOI: 10.1038/376553A0  0.355
1995 Downward J. The Oncogene FactsBook Trends in Biochemical Sciences. 20: 486. DOI: 10.1016/S0968-0004(00)89109-4  0.372
1994 Downward J. The GRB2/Sem-5 adaptor protein. Febs Letters. 338: 113-7. PMID 8307166 DOI: 10.1016/0014-5793(94)80346-3  0.412
1994 Pronk GJ, de Vries-Smits AM, Buday L, Downward J, Maassen JA, Medema RH, Bos JL. Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras. Molecular and Cellular Biology. 14: 1575-81. PMID 8114695 DOI: 10.1128/Mcb.14.3.1575  0.542
1994 Downward J. Signal transduction. Regulating S6 kinase. Nature. 371: 378-9. PMID 8090217 DOI: 10.1038/371378A0  0.353
1994 Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature. 370: 527-32. PMID 8052307 DOI: 10.1038/370527A0  0.622
1994 Arvidsson AK, Rupp E, NÃ¥nberg E, Downward J, Rönnstrand L, Wennström S, Schlessinger J, Heldin CH, Claesson-Welsh L. Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation. Molecular and Cellular Biology. 14: 6715-26. PMID 7935391 DOI: 10.1128/Mcb.14.10.6715  0.414
1993 Buday L, Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor Cell. 73: 611-620. PMID 8490966 DOI: 10.1016/0092-8674(93)90146-H  0.419
1993 Buday L, Downward J. Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts. Molecular and Cellular Biology. 13: 1903-1910. PMID 8441421 DOI: 10.1128/Mcb.13.3.1903  0.446
1993 Warne PH, Viciana PR, Downward J. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature. 364: 352-5. PMID 8332195 DOI: 10.1038/364352A0  0.415
1993 Simon M, Dodson G, Rubin G, Olivier J, Egan S, Giddings B, Brooks M, Buday L, Sizeland A, Weinberg R, Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D, ... ... Downward J, et al. Tyrosine kinases to Ras Trends in Cell Biology. 3: 228. DOI: 10.1016/0962-8924(93)90117-J  0.723
1993 Zhang X, Warne P, Viciana P, Downward J, Hughes D. Ras to raf to MAPKK Trends in Cell Biology. 3: 333. DOI: 10.1016/0962-8924(93)90098-L  0.338
1992 Downward J. Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins. Current Opinion in Genetics & Development. 2: 13-8. PMID 1633420 DOI: 10.1016/S0959-437X(05)80315-6  0.368
1992 Downward J, Graves J, Cantrell D. The regulation and function of p21ras in T cells. Immunology Today. 13: 89-92. PMID 1622545 DOI: 10.1016/0167-5699(92)90148-Z  0.335
1992 Izquierdo M, Downward J, Graves JD, Cantrell DA. Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells. Molecular and Cellular Biology. 12: 3305-12. PMID 1620132 DOI: 10.1128/Mcb.12.7.3305  0.414
1992 Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature. 356: 713-5. PMID 1570015 DOI: 10.1038/356713A0  0.389
1992 Downward J. Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins Current Biology. 2: 165. DOI: 10.1016/0960-9822(92)90282-F  0.315
1992 Rayter S, Woodrow M, Lucas S, Cantrell D, Downward J. p21ras mediates control of IL-2 gene promoter function in T cell activation. The Embo Journal. 11: 4549-4556. DOI: 10.1002/J.1460-2075.1992.Tb05556.X  0.406
1992 Downward J. Regulatory mechanisms forras proteins Bioessays. 14: 177-184. DOI: 10.1002/Bies.950140308  0.43
1991 Wang XF, Lin HY, Ng-Eaton E, Downward J, Lodish HF, Weinberg RA. Expression cloning and characterization of the TGF-beta type III receptor. Cell. 67: 797-805. PMID 1657407 DOI: 10.1016/0092-8674(91)90074-9  0.483
1990 Downward J, Riehl R, Wu L, Weinberg RA. Identification of a nucleotide exchange-promoting activity for p21ras. Proceedings of the National Academy of Sciences of the United States of America. 87: 5998-6002. PMID 2116014 DOI: 10.1073/Pnas.87.15.5998  0.546
1990 Downward J, Graves JD, Warne PH, Rayter S, Cantrell DA. Stimulation of p21ras upon T-cell activation Nature. 346: 719-723. DOI: 10.1038/346719A0  0.41
1990 Downward J. The ras superfamily of small GTP-binding proteins Trends in Biochemical Sciences. 15: 469-472. DOI: 10.1016/0968-0004(90)90300-Z  0.373
1989 Hsuan JJ, Downward J, Clark S, Waterfield MD. Proteolytic generation of constitutive tyrosine kinase activity of the human insulin receptor. The Biochemical Journal. 259: 519-27. PMID 2719663 DOI: 10.1042/Bj2590519  0.566
1988 Collins MK, Downward J, Miyajima A, Maruyama K, Arai K, Mulligan RC. Transfer of functional EGF receptors to an IL3-dependent cell line. Journal of Cellular Physiology. 137: 293-8. PMID 3263970 DOI: 10.1002/Jcp.1041370212  0.388
1988 Downward J, Weinberg RA. Influence of p21ras on phosphatidylinositol turnover. Cold Spring Harbor Symposia On Quantitative Biology. 53: 883-92. PMID 2908199 DOI: 10.1101/Sqb.1988.053.01.101  0.452
1988 Downward J, de Gunzburg J, Riehl R, Weinberg RA. p21ras-induced responsiveness of phosphatidylinositol turnover to bradykinin is a receptor number effect. Proceedings of the National Academy of Sciences of the United States of America. 85: 5774-8. PMID 2901087 DOI: 10.1073/Pnas.85.16.5774  0.544
1987 Berger MS, Greenfield C, Gullick WJ, Haley J, Downward J, Neal DE, Harris AL, Waterfield MD. Evaluation of epidermal growth factor receptors in bladder tumours. British Journal of Cancer. 56: 533-7. PMID 3426916 DOI: 10.1038/Bjc.1987.238  0.549
1986 Gullick WJ, Downward J, Foulkes JG, Waterfield MD. Antibodies to the ATP-binding site of the human epidermal growth factor (EGF) receptor as specific inhibitors of EGF-stimulated protein-tyrosine kinase activity. European Journal of Biochemistry. 158: 245-53. PMID 3015611 DOI: 10.1111/J.1432-1033.1986.Tb09744.X  0.593
1985 Gullick WJ, Marsden JJ, Downward J, Waterfield MD. The use of anti-synthetic peptide antibodies to study the v-erb B protein from chicken and rat cells transformed by avian erythroblastosis virus Journal of Cell Science. 151-160. PMID 3914991 DOI: 10.1242/Jcs.1985.Supplement_3.15  0.543
1985 Gullick WJ, Downward J, Parker PJ, Whittle N, Kris R, Schlessinger J, Ullrich A, Waterfield MD. The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies. Proceedings of the Royal Society of London. Series B, Biological Sciences. 226: 127-34. PMID 2866520 DOI: 10.1098/Rspb.1985.0087  0.554
1985 Gullick WJ, Downward J, Waterfield MD. Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function. The Embo Journal. 4: 2869-77. PMID 2415353 DOI: 10.1002/J.1460-2075.1985.Tb04016.X  0.569
1985 Downward J, Waterfield MD, Parker PJ. Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity. Journal of Biological Chemistry. 260: 14538-14546. DOI: 10.1016/s0021-9258(17)38602-7  0.547
1984 Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 307: 521-7. PMID 6320011 DOI: 10.1038/307521A0  0.643
1984 Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 311: 483-5. PMID 6090945 DOI: 10.1038/311483A0  0.597
Low-probability matches (unlikely to be authored by this person)
2012 Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, ... ... Downward J, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. The New England Journal of Medicine. 366: 883-92. PMID 22397650 DOI: 10.1056/Nejmoa1113205  0.3
2009 Lee A, East P, Nicke B, Jones N, Downward J, Gorman P, Roylance R, Murphy N, Hanby A, Swanton C. A Functional Role for CERT in Cancer Drug Induced Autophagy and Prognosis in Her2 Positive Breast Cancer. Cancer Research. 69: 1137-1137. DOI: 10.1158/0008-5472.Sabcs-09-1137  0.299
2009 Cully M, Downward J. Translational responses to growth factors and stress. Biochemical Society Transactions. 37: 284-8. PMID 19143647 DOI: 10.1042/Bst0370284  0.299
2005 Downward J. RNA interference libraries prove their worth in hunt for tumor suppressor genes. Cell. 121: 813-5. PMID 15960967 DOI: 10.1016/J.Cell.2005.06.002  0.298
2010 Swanton C, Larkin JM, Gerlinger M, Eklund AC, Howell M, Stamp G, Downward J, Gore M, Futreal PA, Escudier B, Andre F, Albiges L, Beuselinck B, Oudard S, Hoffmann J, et al. Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets. Genome Medicine. 2: 53. PMID 20701793 DOI: 10.1186/Gm174  0.298
2019 Foster H, Ruiz EJ, Moore C, Stamp GWH, Nye EL, Li N, Pan Y, He Y, Downward J, Behrens A. ATMIN is a tumor suppressor gene in lung adenocarcinoma. Cancer Research. PMID 31481498 DOI: 10.1158/0008-5472.Can-19-0647  0.298
2003 Iaccarino I, Hancock D, Evan G, Downward J. c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner. Cell Death & Differentiation. 10: 599-608. PMID 12728258 DOI: 10.1038/Sj.Cdd.4401211  0.297
2006 Klupsch K, Downward J. The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi. Cell Death and Differentiation. 13: 2157-9. PMID 16691211 DOI: 10.1038/Sj.Cdd.4401955  0.297
2015 Pender A, Garcia-Murillas I, Rana S, Cutts RJ, Kelly G, Fenwick K, Kozarewa I, Gonzalez de Castro D, Bhosle J, O'Brien M, Turner NC, Popat S, Downward J. Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach. Plos One. 10: e0139074. PMID 26413866 DOI: 10.1371/Journal.Pone.0139074  0.295
2019 Maldegem Fv, Valand K, Tsang V, Mugarza E, Caswell D, Hobson P, Downward J. Abstract A160: Deep immunoprofiling of mouse lung cancer models in steady state and upon drug treatment. Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A160  0.295
2012 Bruin Ed, Cowell C, Howell M, Varmus H, Politi K, Downward J. Abstract A18: Reduced NF1 expression in resistance to EGF receptor inhibitory drugs in lung adenocarcinoma Clinical Cancer Research. 18. DOI: 10.1158/1078-0432.Mechres-A18  0.295
2015 Sheridan C, Downward J. Overview of KRAS-Driven Genetically Engineered Mouse Models of Non-Small Cell Lung Cancer Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. 70: 14.35.1-14.35.16. PMID 26331885 DOI: 10.1002/0471141755.Ph1435S70  0.294
2007 Swanton C, Nicke B, Marani M, Kelly G, Downward J. Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs. Cell Cycle (Georgetown, Tex.). 6: 2001-4. PMID 17721083 DOI: 10.4161/Cc.6.16.4538  0.292
2009 Tain LS, Chowdhury RB, Tao RN, Plun-Favreau H, Moisoi N, Martins LM, Downward J, Whitworth AJ, Tapon N. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death and Differentiation. 16: 1118-25. PMID 19282869 DOI: 10.1038/Cdd.2009.23  0.291
2023 Ismail M, Martin SR, George R, Houghton F, Kelly G, Chaleil RAG, Anastasiou P, Wang X, O'Reilly N, Federico S, Joshi D, Nagaraj H, Cooley R, Hui NS, Molina-Arcas M, ... ... Downward J, et al. Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α. Scientific Reports. 13: 1889. PMID 36732563 DOI: 10.1038/s41598-023-28756-0  0.291
2006 Downward J. Cancer biology: signatures guide drug choice. Nature. 439: 274-5. PMID 16421553 DOI: 10.1038/439274A  0.29
2019 Hill C, Li J, Liu D, Conforti F, Brereton CJ, Yao L, Zhou Y, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Ottensmeier CH, Steele AJ, Downward J, et al. Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. Cell Death & Disease. 10: 591. PMID 31391462 DOI: 10.1038/S41419-019-1820-X  0.289
2011 Lara R, Taylor H, Dallman M, Lamb J, Waelkens E, Bates P, Zicha D, Downward J, Seckl MJ, Pardo OE. RSK1 is a key regulator of lung cancer metastasis F1000research. 2. DOI: 10.7490/F1000Research.1041.1  0.287
2004 Michl P, Ei'Bahrawy M, Poulsom R, Ramjaun A, Downward J. CUTL1–a modulator of tumor cell invasion and target of TGF-beta which is highly expressed in colon cancer Zeitschrift FüR Gastroenterologie. 42. DOI: 10.1055/S-2004-831432  0.285
2005 Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, Müller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, Krüger R. Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Human Molecular Genetics. 14: 2099-111. PMID 15961413 DOI: 10.1093/Hmg/Ddi215  0.283
2020 van Maldegem F, Downward J. Mutant KRAS at the Heart of Tumor Immune Evasion. Immunity. 52: 14-16. PMID 31951548 DOI: 10.1016/J.Immuni.2019.12.013  0.282
2003 Downward J. Cell biology: metabolism meets death. Nature. 424: 896-7. PMID 12931174 DOI: 10.1038/424896A  0.28
1992 Izquierdo M, Downward J, Otani H, Leonard WJ, Cantrell DA. Interleukin (IL)-2 activation of p21ras in murine myeloid cells transfected with human IL-2 receptor beta chain. European Journal of Immunology. 22: 817-21. PMID 1547824 DOI: 10.1002/Eji.1830220328  0.28
1985 Downward J, Waterfield MD, Parker PJ. Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor Journal of Biological Chemistry. 260: 14538-14546. PMID 2997213  0.28
2015 Pender A, Garcia-Murillas I, Rana S, Castro DGd, Turner N, Popat S, Downward J. Abstract 2408: A novel multiplex droplet digital PCR approach to KRAS mutation detection in circulating tumor DNA Cancer Research. 75: 2408-2408. DOI: 10.1158/1538-7445.Am2015-2408  0.275
1992 Downward J. Signal transduction. Rac and Rho in tune. Nature. 359: 273-4. PMID 1406929 DOI: 10.1038/359273A0  0.275
2009 Downward J. 128 Investigation of RAS and PI 3-kinase signaling networks in cancer using synthetic lethal screens European Journal of Cancer Supplements. 7: 33. DOI: 10.1016/S1359-6349(09)70114-4  0.275
2023 Boumelha J, Molina-Arcas M, Downward J. Facts and hopes on RAS inhibitors and cancer immunotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 37581538 DOI: 10.1158/1078-0432.CCR-22-3655  0.274
2015 Kumar MS, Armenteros-Monterroso E, East P, Chakravorty P, Matthews N, Winslow MM, Downward J. Retraction: HMGA2 functions as a competing endogenous RNA to promote lung cancer progression. Nature. 523: 370. PMID 26061768 DOI: 10.1038/Nature14551  0.274
2014 Pender A, Garcia-Murillas I, de Castro DG, Popat S, Downward J. 13 Molecular profiling of non-small cell lung cancer (NSCLC) – the liquid biopsy comes of age Lung Cancer. 83: S5. DOI: 10.1016/S0169-5002(14)70014-5  0.273
1999 Downward J. The Role of PI3-Kinase in the Regulation of Cell Survival and Apoptosis Biochemical Society Transactions. 27: A74-A74. DOI: 10.1042/BST027A074  0.272
2013 Fritsch R, Downward J. SnapShot: Class I PI3K isoform signaling. Cell. 154: 940-940.e1. PMID 23953121 DOI: 10.1016/J.Cell.2013.07.045  0.271
2008 Chua B, Ullrich A, Gallego-Ortega D, Ramirez de Molina A, Lacal J, Downward J. 222 POSTER RNAi screen for Akt regulator European Journal of Cancer Supplements. 6: 70. DOI: 10.1016/S1359-6349(08)72154-2  0.271
2009 Downward J, Basu S. YAP and p73: a complex affair. Molecular Cell. 32: 749-50. PMID 19111652 DOI: 10.1016/J.Molcel.2008.12.002  0.27
2001 Schulze A, Lehmann K, Jefferies HB, McMahon M, Downward J. Analysis of the transcriptional program induced by Raf in epithelial cells Nature Genetics. 27: 85-85. DOI: 10.1038/87290  0.269
2020 Cooley R, Kara N, Hui NS, Tart J, Roustan C, George R, Hancock DC, Binkowski BF, Wood KV, Ismail M, Downward J. Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets. Wellcome Open Research. 5: 20. PMID 32587898 DOI: 10.12688/wellcomeopenres.15675.1  0.269
2008 Lee AJ, East P, Pepper S, Nicke B, Szallasi Z, Eklund AC, Downward J, Swanton C. Concordance of exon array and real-time PCR assessment of gene expression following cancer cell cytotoxic drug exposure. Cell Cycle (Georgetown, Tex.). 7: 3947-8. PMID 19066460 DOI: 10.4161/Cc.7.24.7217  0.266
2004 Downward J. RNA interference-based functional genomics in cancer research--an introduction. Oncogene. 23: 8334-5. PMID 15517012 DOI: 10.1038/Sj.Onc.1208121  0.265
2022 East P, Kelly GP, Biswas D, Marani M, Hancock DC, Creasy T, Sachsenmeier K, Swanton C, Downward J, de Carné Trécesson S. RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma. Nature Communications. 13: 5632. PMID 36163168 DOI: 10.1038/s41467-022-33290-0  0.264
2008 Moisoi N, Klupsch K, Fedele V, East P, Sharma S, Renton A, Plun-Favreau H, Edwards RE, Teismann P, Esposti MD, Morrison AD, Wood NW, Downward J, Martins LM. Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. Cell Death and Differentiation. 16: 449-64. PMID 19023330 DOI: 10.1038/Cdd.2008.166  0.264
2021 Ruiz EJ, Lan L, Diefenbacher ME, Riising EM, Da Costa C, Chakraborty A, Hoeck JD, Spencer-Dene B, Kelly G, David JP, Nye E, Downward J, Behrens A. JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. Jci Insight. 6. PMID 34236045 DOI: 10.1172/jci.insight.124985  0.263
2021 Zhou Y, Hill C, Yao L, Li J, Hancock D, Downward J, Jones MG, Davies DE, Ewing RM, Skipp P, Wang Y. Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial-Mesenchymal Transition. Frontiers in Molecular Biosciences. 8: 595712. PMID 33869273 DOI: 10.3389/fmolb.2021.595712  0.262
2021 Yao L, Zhou Y, Li J, Wickens L, Conforti F, Rattu A, Ibrahim FM, Alzetani A, Marshall BG, Fletcher SV, Hancock D, Wallis T, Downward J, Ewing RM, Richeldi L, et al. Bi-directional epithelial-mesenchymal crosstalk provides self-sustaining pro-fibrotic signals in pulmonary fibrosis. The Journal of Biological Chemistry. 101096. PMID 34418430 DOI: 10.1016/j.jbc.2021.101096  0.261
2004 Downward J. RNA interference. Bmj (Clinical Research Ed.). 328: 1245-8. PMID 15155505 DOI: 10.1136/Bmj.328.7450.1245  0.26
2011 Roylance R, Endesfelder D, Gorman P, Burrell RA, Sander J, Tomlinson I, Hanby AM, Speirs V, Richardson AL, Birkbak NJ, Eklund AC, Downward J, Kschischo M, Szallasi Z, Swanton C. Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 2183-94. PMID 21784954 DOI: 10.1158/1055-9965.Epi-11-0343  0.26
1994 Buday L, Egan S, Rodriguez Viciana P, Cantrell D, Downward J. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. Journal of Biological Chemistry. 269: 9019-9023. DOI: 10.1016/s0021-9258(17)37070-9  0.258
2003 Seckl MJ, Pardo O, Arcaro A, Downward J. O-177 A novel epigenetic mechanism of chemo-resistance in SCLC induced by fibroblast growth factor-2 (FGF-2): dissociation of Smac/DIABLO from cytochrome c release Lung Cancer. 41: S53. DOI: 10.1016/S0169-5002(03)91835-6  0.256
2021 Molina-Arcas M, Samani A, Downward J. Drugging the Undruggable: Advances on RAS Targeting in Cancer. Genes. 12. PMID 34200676 DOI: 10.3390/genes12060899  0.254
2003 Agathanggelou A, Bièche I, Ahmed-Choudhury J, Nicke B, Dammann R, Baksh S, Gao B, Minna JD, Downward J, Maher ER, Latif F. Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma. Cancer Research. 63: 5344-51. PMID 14500366  0.253
2014 Geraghty RJ, Capes-Davis A, Davis JM, Downward J, Freshney RI, Knezevic I, Lovell-Badge R, Masters JR, Meredith J, Stacey GN, Thraves P, Vias M. Guidelines for the use of cell lines in biomedical research. British Journal of Cancer. 111: 1021-46. PMID 25117809 DOI: 10.1038/Bjc.2014.166  0.253
2001 Schulze A, Downward J. Navigating gene expression using microarrays--a technology review. Nature Cell Biology. 3: E190-5. PMID 11483980 DOI: 10.1038/35087138  0.253
2016 Molina-Arcas M, Hancock D, Moore C, Horswell S, Matthews N, Downward J. Identification of new combination therapies for NSCLC tumours harbouring KRAS mutations European Journal of Cancer. 61: S56. DOI: 10.1016/S0959-8049(16)61193-0  0.25
2016 Pender A, Rana S, Delgado EI, Proszek P, Garcia-Murillas I, Bhosle J, O'Brien M, Palma JF, Turner NC, Popat S, Downward J, Gonzalez D. 3 EGFR mutant circulating tumour DNA detection in advanced lung adenocarcinoma: optimising the application of a ctDNA diagnostic to real world clinical practice Lung Cancer. 91. DOI: 10.1016/S0169-5002(16)30020-4  0.247
1996 Downward J. Measurement of nucleotide exchange and hydrolysis activities in immunoprecipitates. Methods in Enzymology. 255: 110-7. PMID 8524092 DOI: 10.1016/S0076-6879(95)55013-5  0.246
2001 Downward J. The ins and outs of signalling. Nature. 411: 759-62. PMID 11459043 DOI: 10.1038/35081138  0.246
2009 Downward J. Finding the weakness in cancer. The New England Journal of Medicine. 361: 922-4. PMID 19710492 DOI: 10.1056/Nejmcibr0905242  0.245
2002 Downward J. Update on The Big C: complexity and cross-talk between pathways Current Opinion in Genetics & Development. 12: 11-13. DOI: 10.1016/S0959-437X(01)00257-X  0.244
1992 Downward J. Signal transduction. Exchange rate mechanisms. Nature. 358: 282-3. PMID 1640998 DOI: 10.1038/358282A0  0.244
1994 Hallberg B, Rayter S, Downward J. Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. Journal of Biological Chemistry. 269: 3913-3916. DOI: 10.1016/s0021-9258(17)41718-2  0.244
2014 Swee JKY, Sheridan C, De Bruin E, Downward J, Lassailly F, Pizarro L. Automated segmentation of murine lung tumors in x-ray micro-CT images Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9035. DOI: 10.1117/12.2042443  0.244
2009 Liu ML, Liu MJ, Shen YF, Ryu H, Kim HJ, Klupsch K, Downward J, Hong ST. Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta. Journal of Cell Science. 122: 1917-26. PMID 19435805 DOI: 10.1242/Jcs.042226  0.243
2009 Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW, Duchen MR, Abramov AY. PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Molecular Cell. 33: 627-38. PMID 19285945 DOI: 10.1016/J.Molcel.2009.02.013  0.243
1994 Reif K, Buday L, Downward J, Cantrell D. SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. Journal of Biological Chemistry. 269: 14081-14087. DOI: 10.1016/s0021-9258(17)36757-1  0.242
2009 Ding X, Patel M, Shen D, Herzlich AA, Cao X, Villasmil R, Klupsch K, Tuo J, Downward J, Chan CC. Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. Investigative Ophthalmology & Visual Science. 50: 4957-66. PMID 19443712 DOI: 10.1167/Iovs.09-3381  0.242
2021 Chrysostomou S, Roy R, Prischi F, Thamlikitkul L, Chapman KL, Mufti U, Peach R, Ding L, Hancock D, Moore C, Molina-Arcas M, Mauri F, Pinato DJ, Abrahams JM, Ottaviani S, ... ... Downward J, et al. Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer. Science Translational Medicine. 13. PMID 34261798 DOI: 10.1126/scitranslmed.aba4627  0.242
2008 Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Abramov AS, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, et al. PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. Plos One. 3: e2455. PMID 18560593 DOI: 10.1371/Journal.Pone.0002455  0.241
2004 Swanton C, Nicke B, Downward J. RNA interference, DNA methylation, and gene silencing: a bright future for cancer therapy? The Lancet. Oncology. 5: 653-4. PMID 15522650 DOI: 10.1016/S1470-2045(04)01604-3  0.237
2020 Ertay A, Liu H, Liu D, Peng P, Hill C, Xiong H, Hancock D, Yuan X, Przewloka MR, Coldwell M, Howell M, Skipp P, Ewing RM, Downward J, Wang Y. WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. Cell Death & Disease. 11: 1001. PMID 33221821 DOI: 10.1038/s41419-020-03210-5  0.236
2012 Burrell RA, McClelland SE, Endesfelder D, Rowan A, Schenk A, Sheffer M, Shaikh N, Domingo E, Kschischo M, Domany E, Downward J, Tomlinson I, Swanton C. Abstract 3105: Chromosome 18q encodes a chromosomal instability suppressor locus in colorectal cancer Cancer Research. 72: 3105-3105. DOI: 10.1158/1538-7445.Am2012-3105  0.233
2005 Swanton C, Downward J. Small and interfering The Lancet Oncology. 6: 457. DOI: 10.1016/S1470-2045(05)70240-0  0.232
2012 Kumar M, Downward J. 509 The GATA2 Transcriptional Network is Requisite for Ras Oncogene-driven Non-small Cell Lung Cancer European Journal of Cancer. 48: S121. DOI: 10.1016/S0959-8049(12)71173-5  0.229
2008 Downward J. Targeting RAS and PI3K in lung cancer Nature Medicine. 14: 1315-1316. DOI: 10.1038/nm1208-1315  0.228
1998 Downward J. 1997 Salk Institute/EMBL meeting on Oncogenes and Growth Control, Salk Institute, La Jolla, California, 16-20 August 1997. Biochimica Et Biophysica Acta. 1377: R51-3. PMID 9659405 DOI: 10.1016/S0304-419X(98)00006-7  0.225
2008 Kawamoto Y, Kobayashi Y, Suzuki Y, Inoue H, Tomimoto H, Akiguchi I, Budka H, Martins LM, Downward J, Takahashi R. Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies. Journal of Neuropathology and Experimental Neurology. 67: 984-93. PMID 18800009 DOI: 10.1097/Nen.0B013E31818809F4  0.223
2016 Raz R, Burlina F, Ismail M, Downward J, Li J, Smerdon SJ, Quibell M, White PD, Offer J. HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization. Angewandte Chemie (International Ed. in English). PMID 27654901 DOI: 10.1002/Anie.201607657  0.223
2016 Raz R, Burlina F, Ismail M, Downward J, Li J, Smerdon SJ, Quibell M, White PD, Offer J. HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization Angewandte Chemie. 128: 13368-13373. DOI: 10.1002/Ange.201607657  0.223
2024 Xu Z, Davies ER, Yao L, Zhou Y, Li J, Alzetani A, Marshall BG, Hancock D, Wallis T, Downward J, Ewing RM, Davies DE, Jones MG, Wang Y. LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis. Genes & Diseases. 11: 101065. PMID 38222900 DOI: 10.1016/j.gendis.2023.06.034  0.222
2022 Vaclova T, Chakraborty A, Sherwood J, Ross S, Carroll D, Barrett JC, Downward J, de Bruin EC. Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition. Scientific Reports. 12: 2699. PMID 35177674 DOI: 10.1038/s41598-022-06369-3  0.219
1996 de Vries-Smits AM, Downward J, Bos JL. Measurements of GTP/GDP exchange in permeabilized fibroblasts. Methods in Enzymology. 255: 156-61. PMID 8524099 DOI: 10.1016/S0076-6879(95)55019-4  0.218
2021 Vaclova T, Grazini U, Ward L, O'Neill D, Markovets A, Huang X, Chmielecki J, Hartmaier R, Thress KS, Smith PD, Barrett JC, Downward J, de Bruin EC. Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers. Nature Communications. 12: 1780. PMID 33741979 DOI: 10.1038/s41467-021-22057-8  0.218
1985 Downward J. Growth and maturation factors, volume 2, G. Guroff (Ed.), John Wiley & Sons, Chichester, 1984. xiii + 340 pp. incl. index. Price: £66. ISBN 0 471 09708 X Hematological Oncology. 3: 218-218. DOI: 10.1002/Hon.2900030313  0.217
2010 de Bruin E, Cowell C, Howell M, Downward J. 220 Identification of resistance mechanisms to EGFR inhibitors in non-small cell lung cancer cells European Journal of Cancer Supplements. 8: 57-58. DOI: 10.1016/S1359-6349(10)71027-2  0.215
1994 DOWNWARD J. The GTPase superfamily (Ciba foundation symposium 176)edited by Joan Marsh and Jamie Goode, John Wiley, 1993, £45.00 (289 pages) ISBN 0 471 93914 5 Trends in Cell Biology. 4: 104-104. DOI: 10.1016/0962-8924(94)90183-X  0.214
2008 Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, et al. Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons Plos One. 3. DOI: 10.1371/Annotation/17D5Aaa1-C6D8-4Aad-A9A4-56B2C1220C83  0.212
1986 Sutherland DR, Bicknell DC, Downward J, Parker P, Waterfield MD, Baker MA, Greaves MF, Stanbridge EJ. Structural and functional features of a cell surface phosphoglycoprotein associated with tumorigenic phenotype in human fibroblast x HeLa cell hybrids. The Journal of Biological Chemistry. 261: 2418-24. PMID 3080434  0.212
2023 Caswell DR, Gui P, Mayekar MK, Law EK, Pich O, Bailey C, Boumelha J, Kerr DL, Blakely CM, Manabe T, Martinez-Ruiz C, Bakker B, De Dios Palomino Villcas J, I Vokes N, Dietzen M, ... ... Downward J, et al. The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance. Nature Genetics. PMID 38049664 DOI: 10.1038/s41588-023-01592-8  0.21
2022 Mugarza E, van Maldegem F, Boumelha J, Moore C, Rana S, Llorian Sopena M, East P, Ambler R, Anastasiou P, Romero-Clavijo P, Valand K, Cole M, Molina-Arcas M, Downward J. Therapeutic KRAS inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers. Science Advances. 8: eabm8780. PMID 35857848 DOI: 10.1126/sciadv.abm8780  0.209
2020 East P, Kelly G, Biswas D, Hancock D, Swanton C, de Carne S, Downward J. Stratification method based on RAS pathway oncogenic activity predicts outcome in lung adenocarcinoma European Journal of Cancer. 138: S18. DOI: 10.1016/s0959-8049(20)31113-8  0.209
2004 Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD, Lemoine NR, Mehmet H, Seckl MJ, Downward J. Fibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells Molecular and Cellular Biology. 24: 6887-6887. DOI: 10.1128/mcb.24.15.6887.2004  0.203
2012 Downward J. 9 Mechanisms of transformation by RAS oncogenes: searching for novel therapeutic approaches European Journal of Cancer. 48: 7. DOI: 10.1016/S0959-8049(12)71808-7  0.194
2005 Downward J. Plugging the GAPs. Current Biology : Cb. 1: 353-5. PMID 15336077 DOI: 10.1016/0960-9822(91)90190-8  0.183
2020 de Carné Trécesson S, Boumhela J, Moore C, Caswell D, Mugarza-Strobl E, Molina-Arcas M, Smith P, Sachsenmeier K, East P, Downward J. RAS orchestrates an increase of interstitial adenosine in lung adenocarcinoma to promote immune evasion European Journal of Cancer. 138: S20-S21. DOI: 10.1016/s0959-8049(20)31119-9  0.181
2022 Boumelha J, de Carné Trécesson S, Law EK, Romero-Clavijo P, Coelho M, Ng K, Mugarza E, Moore C, Rana S, Caswell DR, Murillo M, Hancock DC, Argyris PP, Brown WL, Durfee C, ... ... Downward J, et al. An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations. Cancer Research. PMID 35930804 DOI: 10.1158/0008-5472.CAN-22-0325  0.18
2023 Ng KW, Boumelha J, Enfield KSS, Almagro J, Cha H, Pich O, Karasaki T, Moore DA, Salgado R, Sivakumar M, Young G, Molina-Arcas M, de Carné Trécesson S, Anastasiou P, Fendler A, ... ... Downward J, et al. Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature. PMID 37046094 DOI: 10.1038/s41586-023-05771-9  0.178
2018 Zecchin D, Howell M, Horswell S, Downward J. 20 Identification of combinatorial therapies with inhibitors of the PI3K pathway in PTEN-null tumours Esmo Open. 3: A9. DOI: 10.1136/esmoopen-2018-EACR25.20  0.174
2020 Van Maldegem F, Mugarza E, Molina-Arcas M, Valand K, Rana S, Cole M, Romero-Clavijo P, Boumelha J, Moore C, Downward J. Targeting oncogenic signalling pathways to modulate the lung cancer immune microenvironment European Journal of Cancer. 138: S60. DOI: 10.1016/s0959-8049(20)31238-7  0.172
2023 Chauhan J, Grandits M, Palhares LCGF, Mele S, Nakamura M, López-Abente J, Crescioli S, Laddach R, Romero-Clavijo P, Cheung A, Stavraka C, Chenoweth AM, Sow HS, Chiaruttini G, Gilbert AE, ... ... Downward J, et al. Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4. Nature Communications. 14: 2192. PMID 37185332 DOI: 10.1038/s41467-023-37811-3  0.17
2004 Downward J. Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells. Oncogene. 23: 8376-83. PMID 15517019 DOI: 10.1038/sj.onc.1208073  0.167
2021 van Maldegem F, Valand K, Cole M, Patel H, Angelova M, Rana S, Colliver E, Enfield K, Bah N, Kelly G, Tsang VSK, Mugarza E, Moore C, Hobson P, Levi D, ... ... Downward J, et al. Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry. Nature Communications. 12: 5906. PMID 34625563 DOI: 10.1038/s41467-021-26214-x  0.138
2018 Molina-Arcas M, Moore C, Rana S, Van Maldegem F, Horswell S, Hancock D, Downward J. 15 Identification of new combination therapies for lung cancer tumours harbouring KRAS mutations Esmo Open. 3: A7. DOI: 10.1136/esmoopen-2018-EACR25.15  0.137
2004 Downward J. RNAi and cancer research: The path to a cure? The Biochemist. 26: 12-15. DOI: 10.1042/bio02605012  0.137
2024 Ocasio CA, Baggelaar MP, Sipthorp J, Losada de la Lastra A, Tavares M, Volarić J, Soudy C, Storck EM, Houghton JW, Palma-Duran SA, MacRae JI, Tomić G, Carr L, Downward J, Eggert US, et al. A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature Biotechnology. PMID 38191663 DOI: 10.1038/s41587-023-02030-0  0.137
2024 Enfield KSS, Colliver E, Lee CSY, Magness A, Moore DA, Sivakumar M, Grigoriadis K, Pich O, Karasaki T, Hobson PS, Levi D, Veeriah S, Puttick C, Nye EL, Green M, ... ... Downward J, et al. Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer Discovery. PMID 38581685 DOI: 10.1158/2159-8290.CD-23-1380  0.137
2015 de Bruin E, Jiang M, Howell M, Downward J. Genome-Wide siRNA Screen for Anti-Cancer Drug Resistance in Adherent Cell Lines Bio-Protocol. 5. DOI: 10.21769/BIOPROTOC.1474  0.121
2024 Molina-Arcas M, Downward J. Exploiting the therapeutic implications of KRAS inhibition on tumor immunity. Cancer Cell. 42: 338-357. PMID 38471457 DOI: 10.1016/j.ccell.2024.02.012  0.12
2012 Sheridan C, Castellano E, Murillo M, Downward J. 354 Exploration of the Role of Ras–PI3K Interaction in Lung Tumor Maintenance European Journal of Cancer. 48: 108. DOI: 10.1016/S0959-8049(12)72152-4  0.108
2003 Khanna S, Warnasuriya GD, Downward J, Naaby-Hansen S. RNAi and 2DE, a promising combination for analysis of phospho-signalling and substrate identification International Journal of Peptide Research and Therapeutics. 10: 437-445. DOI: 10.1007/s10989-004-3533-x  0.104
2019 Polubothu S, Al-Olabi L, Healy E, Di W, Newton-Bishop J, Downward J, Kinsler V. 474 Inherited duplications of PPP2R3B promote naevi and melanoma via a novel C21orf91-driven proliferative phenotype Journal of Investigative Dermatology. 139: S296. DOI: 10.1016/j.jid.2019.07.524  0.097
2021 Ertay A, Liu H, Liu D, Peng P, Hill C, Xiong H, Hancock D, Yuan X, Przewloka MR, Coldwell M, Howell M, Skipp P, Ewing RM, Downward J, Wang Y. Correction: WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. Cell Death & Disease. 12: 269. PMID 33723224 DOI: 10.1038/s41419-021-03530-0  0.094
2020 Ambler R, Von Karstedt S, Downward J. Targeting a KRAS neoantigen peptide vaccine to DNGR-1+ dendritic cells European Journal of Cancer. 138: S10. DOI: 10.1016/s0959-8049(20)31093-5  0.077
2022 Zaw Thin M, Moore C, Snoeks T, Kalber T, Downward J, Behrens A. Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature Protocols. PMID 36494493 DOI: 10.1038/s41596-022-00769-5  0.069
2021 Polubothu S, Zecchin D, Al-Olabi L, Lionarons DA, Harland M, Horswell S, Thomas AC, Hunt L, Wlodarchak N, Aguilera P, Brand S, Bryant D, Carrera C, Chen H, Elgar G, ... ... Downward J, et al. Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 34145395 DOI: 10.1038/s41436-021-01204-y  0.062
2008 Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, et al. Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons Plos One. 3. DOI: 10.1371/annotation/ba489c2a-5cf2-481c-aff7-d2c8c4ecdcfa  0.05
2022 Molina-Arcas M, Downward J. The Potency of a Silent Variant. The New England Journal of Medicine. 386: 2523-2525. PMID 35767444 DOI: 10.1056/NEJMcibr2202981  0.04
2023 Zaw Thin M, Moore C, Snoeks T, Kalber T, Downward J, Behrens A. Addendum: Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature Protocols. PMID 37095306 DOI: 10.1038/s41596-023-00838-3  0.012
2023 Downward J, Parker PJ, Vanhaesebroeck B. Michael D. Waterfield. The Biochemical Journal. 480: 1475-1478. PMID 37732645 DOI: 10.1042/BCJ20230368  0.01
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