| Year |
Citation |
Score |
| 2022 |
Noh K, Chow ECY, Quach HP, Groothuis GMM, Tirona RG, Pang KS. Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters. The Aaps Journal. 24: 71. PMID 35650371 DOI: 10.1208/s12248-022-00719-9 |
0.812 |
|
| 2022 |
Rowland M, Pang KS. Hepatic clearance models and IVIVE predictions. Clinical Pharmacology and Therapeutics. PMID 35234281 DOI: 10.1002/cpt.2525 |
0.426 |
|
| 2021 |
Rowland M, Roberts MS, Pang KS. . Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 34740891 DOI: 10.1124/dmd.121.000637 |
0.452 |
|
| 2021 |
Peng HB, de Lannoy IAM, Pang KS. Measuring Amyloid-β Peptide Concentrations in Murine Brain with Improved ELISA Assay. Current Protocols. 1: e253. PMID 34661993 DOI: 10.1002/cpz1.253 |
0.771 |
|
| 2021 |
Peng HB, Bukuroshi P, Durk MR, Grootendorst P, Yan X, Pan SR, de Lannoy IAM, Pang KS. Impact of age, hypercholesterolemia and the vitamin D receptor (VDR) on brain endogenous β-amyloid peptide accumulation in mice. Biopharmaceutics & Drug Disposition. PMID 34219248 DOI: 10.1002/bdd.2297 |
0.771 |
|
| 2020 |
Peng HB, Noh K, Pan SR, Saldivia V, Serson S, Toscan A, de Lannoy IAM, Pang KS. Human β-Amyloid 40 (hAβ40) Kinetics after Intravenous (IV) and Intracerebroventricular (ICV) Injections and Calcitriol Treatment in Rats in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 32759365 DOI: 10.1124/dmd.120.090886 |
0.788 |
|
| 2020 |
Noh K, Yang QJ, Sekhon L, Quach HP, Chow ECY, Pang KS. Noteworthy idiosyncrasies of 1α,25-dihydroxyvitamin D kinetics for extrapolation from mouse to man: Commentary. Biopharmaceutics & Drug Disposition. 41: 126-148. PMID 32319119 DOI: 10.1002/bdd.2223 |
0.822 |
|
| 2020 |
Pang KS, Peng HB, Noh K. The Segregated Intestinal Flow Model (SFM) for Drug Absorption and Drug Metabolism: Implications on Intestinal and Liver Metabolism and Drug-Drug Interactions. Pharmaceutics. 12. PMID 32244748 DOI: 10.3390/pharmaceutics12040312 |
0.791 |
|
| 2019 |
Noh K, Pang KS. THEORETICAL CONSIDERATION OF THE PROPERTIES OF INTESTINAL FLOW MODELS ON ROUTE-DEPENDENT DRUG REMOVAL: SEGREGATED FLOW (SFM) vs. TRADITIONAL (TM). Biopharmaceutics & Drug Disposition. PMID 31099032 DOI: 10.1002/bdd.2184 |
0.704 |
|
| 2018 |
Quach HP, Dzekic T, Bukuroshi P, Pang KS. Potencies of vitamin D analogs, 1α-hydroxyvitamin D , 1α-hydroxyvitamin D and 25-hydroxyvitamin D , in lowering cholesterol in hypercholesterolemic mice in vivo. Biopharmaceutics & Drug Disposition. 39: 196-204. PMID 29488238 DOI: 10.1002/bdd.2126 |
0.803 |
|
| 2017 |
Rowland M, Pang KS. Commentary on "The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio". Clinical Pharmacology and Therapeutics. PMID 29134634 DOI: 10.1002/Cpt.921 |
0.424 |
|
| 2017 |
Yang QJ, Bukuroshi P, Quach HP, Chow ECY, Pang KS. Highlighting VDR-Targeted Activities of 1α,25-Dihydroxyvitamin D3 in Mice Via Physiologically-based Pharmacokinetic-Pharmacodynamic Modeling. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29084783 DOI: 10.1124/dmd.117.077271 |
0.818 |
|
| 2016 |
Pang KS, Yang QJ, Noh K. Unequivocal Evidence Supporting the Segregated Flow Intestinal Model that Discriminates Intestine versus Liver First-Pass Removal in PBPK Modeling. Biopharmaceutics & Drug Disposition. PMID 27977852 DOI: 10.1002/bdd.2056 |
0.699 |
|
| 2016 |
Noh K, Chen S, Yang QJ, Pang KS. Physiologically-Based Pharmacokinetic Modeling Revealed Minimal Codeine Intestinal Metabolism in First-Pass Removal in Rats. Biopharmaceutics & Drug Disposition. PMID 27925239 DOI: 10.1002/bdd.2051 |
0.696 |
|
| 2016 |
Chow EC, Quach HP, Zhang Y, Wang JZ, Evan DC, Li AP, Silva J, Tirona RG, Lai Y, Pang KS. Disrupted Murine Gut to Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models. The Journal of Pharmacology and Experimental Therapeutics. PMID 27789682 DOI: 10.1124/jpet.116.236935 |
0.801 |
|
| 2016 |
Chow E, Wang JZ, Quach HP, Tang H, Evans DC, Li AP, Silva J, Pang KS. Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiological Spaces, and Hepatic Enzymes and Transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27342868 DOI: 10.1124/dmd.116.070060 |
0.785 |
|
| 2016 |
Yang QJ, Fan J, Chen S, Liu L, Sun H, Pang KS. Metabolite Kinetics: The Segregated-Flow Model (SFM) for Intestinal and Whole Body PBPK Modeling To Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27098743 DOI: 10.1124/dmd.116.069542 |
0.687 |
|
| 2015 |
Ramakrishnan V, Yang QJ, Quach HP, Cao Y, Chow EC, Mager DE, Pang KS. Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice: Comparison of Minimal and Full PBPK-PD Models. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26586377 DOI: 10.1124/Dmd.115.067033 |
0.796 |
|
| 2015 |
Quach HP, Yang QJ, Chow EC, Mager DE, Hoi SY, Pang KS. PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation. British Journal of Pharmacology. 172: 3611-26. PMID 25829051 DOI: 10.1111/Bph.13153 |
0.81 |
|
| 2015 |
Yang QJ, Si L, Tang H, Sveigaard HH, Chow EC, Pang KS. PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 631-45. PMID 25650380 DOI: 10.1124/dmd.114.062265 |
0.785 |
|
| 2015 |
Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA. Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats. Pharmaceutical Research. 32: 1128-40. PMID 25319098 DOI: 10.1007/s11095-014-1524-y |
0.814 |
|
| 2014 |
Kim YC, Kim IB, Noh CK, Quach HP, Yoon IS, Chow EC, Kim M, Jin HE, Cho KH, Chung SJ, Pang KS, Maeng HJ. Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat. Journal of Pharmaceutical Sciences. 103: 3793-805. PMID 25266751 DOI: 10.1002/jps.24195 |
0.82 |
|
| 2014 |
Durk MR, Han K, Chow EC, Ahrens R, Henderson JT, Fraser PE, Pang KS. 1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7091-101. PMID 24849345 DOI: 10.1523/Jneurosci.2711-13.2014 |
0.808 |
|
| 2014 |
Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS. Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology. 146: 1048-59. PMID 24365583 DOI: 10.1053/J.Gastro.2013.12.027 |
0.809 |
|
| 2013 |
Chow EC, Durk MR, Maeng HJ, Pang KS. Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice. Biopharmaceutics & Drug Disposition. 34: 402-16. PMID 23897575 DOI: 10.1002/bdd.1856 |
0.81 |
|
| 2013 |
Chow EC, Quach HP, Vieth R, Pang KS. Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice. American Journal of Physiology. Endocrinology and Metabolism. 304: E977-89. PMID 23482451 DOI: 10.1152/Ajpendo.00489.2012 |
0.803 |
|
| 2013 |
Chow EC, Pang KS. Why we need proper PBPK models to examine intestine and liver oral drug absorption. Current Drug Metabolism. 14: 57-79. PMID 22935069 |
0.8 |
|
| 2012 |
Durk MR, Chan GN, Campos CR, Peart JC, Chow EC, Lee E, Cannon RE, Bendayan R, Miller DS, Pang KS. 1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells. Journal of Neurochemistry. 123: 944-53. PMID 23035695 DOI: 10.1111/Jnc.12041 |
0.81 |
|
| 2012 |
Pang KS, Chow EC. Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1869-77. PMID 22745334 DOI: 10.1124/dmd.112.045872 |
0.773 |
|
| 2011 |
Chow EC, Durk MR, Cummins CL, Pang KS. 1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo. The Journal of Pharmacology and Experimental Therapeutics. 337: 846-59. PMID 21421739 DOI: 10.1124/Jpet.111.179101 |
0.818 |
|
| 2011 |
Maeng HJ, Durk MR, Chow EC, Ghoneim R, Pang KS. 1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac. Biopharmaceutics & Drug Disposition. 32: 112-25. PMID 21341280 DOI: 10.1002/bdd.742 |
0.807 |
|
| 2011 |
Chow EC, Sondervan M, Jin C, Groothuis GM, Pang KS. Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo. Journal of Pharmaceutical Sciences. 100: 1594-604. PMID 20967888 DOI: 10.1002/jps.22366 |
0.792 |
|
| 2011 |
Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM. The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicology in Vitro : An International Journal Published in Association With Bibra. 25: 80-90. PMID 20888898 DOI: 10.1016/j.tiv.2010.09.011 |
0.798 |
|
| 2010 |
Fan J, Chen S, Chow EC, Pang KS. PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism. Current Drug Metabolism. 11: 743-61. PMID 21189137 DOI: 10.2174/138920010794328931 |
0.81 |
|
| 2010 |
Pang KS, Durk MR. Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion. Journal of Pharmacokinetics and Pharmacodynamics. 37: 591-615. PMID 21153869 DOI: 10.1007/s10928-010-9185-x |
0.722 |
|
| 2010 |
Sun H, Pang KS. Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates. Pharmaceutical Research. 27: 1237-54. PMID 20372987 DOI: 10.1007/s11095-010-0049-2 |
0.678 |
|
| 2010 |
Sun H, Zeng YY, Pang KS. Interplay of phase II enzymes and transporters in futile cycling: influence of multidrug resistance-associated protein 2-mediated excretion of estradiol 17beta-D-glucuronide and its 3-sulfate metabolite on net sulfation in perfused TR(-) and Wistar rat liver preparations. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 769-80. PMID 20124397 DOI: 10.1124/dmd.109.029959 |
0.713 |
|
| 2010 |
Chow EC, Sun H, Khan AA, Groothuis GM, Pang KS. Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo. Biopharmaceutics & Drug Disposition. 31: 91-108. PMID 20013813 DOI: 10.1002/bdd.694 |
0.804 |
|
| 2009 |
Chow EC, Maeng HJ, Liu S, Khan AA, Groothuis GM, Pang KS. 1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo. Biopharmaceutics & Drug Disposition. 30: 457-75. PMID 19753549 DOI: 10.1002/bdd.682 |
0.818 |
|
| 2009 |
Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM. Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharmaceutics & Drug Disposition. 30: 241-58. PMID 19562681 DOI: 10.1002/bdd.663 |
0.807 |
|
| 2009 |
Khan AA, Chow EC, van Loenen-Weemaes AM, Porte RJ, Pang KS, Groothuis GM. Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 37: 115-25. PMID 19429418 DOI: 10.1016/j.ejps.2009.01.006 |
0.807 |
|
| 2009 |
Fan J, Liu S, Du Y, Morrison J, Shipman R, Pang KS. Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer. The Journal of Pharmacology and Experimental Therapeutics. 330: 389-402. PMID 19414624 DOI: 10.1124/jpet.108.149815 |
0.323 |
|
| 2009 |
Sun H, Pang KS. Disparity in intestine disposition between formed and preformed metabolites and implications: a theoretical study. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 187-202. PMID 18948379 DOI: 10.1124/dmd.108.022483 |
0.673 |
|
| 2008 |
Pang KS, Morris ME, Sun H. Formed and preformed metabolites: facts and comparisons. The Journal of Pharmacy and Pharmacology. 60: 1247-75. PMID 18812018 DOI: 10.1211/jpp.60.10.0001 |
0.698 |
|
| 2008 |
Sun H, Chow EC, Liu S, Du Y, Pang KS. The Caco-2 cell monolayer: usefulness and limitations. Expert Opinion On Drug Metabolism & Toxicology. 4: 395-411. PMID 18433344 DOI: 10.1517/17425255.4.4.395 |
0.74 |
|
| 2008 |
Sun H, Zhang L, Chow EC, Lin G, Zuo Z, Pang KS. A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition. The Journal of Pharmacology and Experimental Therapeutics. 326: 117-26. PMID 18385448 DOI: 10.1124/Jpet.108.137463 |
0.776 |
|
| 2008 |
Chow EC, Liu L, Ship N, Kluger RH, Pang KS. Role of haptoglobin on the uptake of native and beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] cross-linked human hemoglobins in isolated perfused rat livers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 937-45. PMID 18276837 DOI: 10.1124/Dmd.107.019174 |
0.797 |
|
| 2008 |
Sun H, Pang KS. Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 102-23. PMID 17932224 DOI: 10.1124/dmd.107.015321 |
0.655 |
|
| 2007 |
Liu L, Sun H, Valji WY, Pang KS. Transporters, enzymes, and enalapril removal in a rat (CC531-induced) liver metastatic model. American Journal of Physiology. Gastrointestinal and Liver Physiology. 293: G1078-88. PMID 17855765 DOI: 10.1152/ajpgi.00350.2006 |
0.709 |
|
| 2006 |
Sun H, Liu L, Pang KS. Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers. The Journal of Pharmacology and Experimental Therapeutics. 319: 818-31. PMID 16895976 DOI: 10.1124/jpet.106.108860 |
0.689 |
|
| 2006 |
Chen X, Chen F, Liu S, Glaeser H, Dawson PA, Hofmann AF, Kim RB, Shneider BL, Pang KS. Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor. Molecular Pharmacology. 69: 1913-23. PMID 16481392 DOI: 10.1124/mol.105.020792 |
0.325 |
|
| 2005 |
Liu L, Pang KS. The roles of transporters and enzymes in hepatic drug processing. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1-9. PMID 15466164 DOI: 10.1124/dmd.104.001149 |
0.302 |
|
| 2003 |
Tam D, Sun H, Pang KS. Influence of P-glycoprotein, transfer clearances, and drug binding on intestinal metabolism in Caco-2 cell monolayers or membrane preparations: a theoretical analysis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1214-26. PMID 12975330 DOI: 10.1124/dmd.31.10.1214 |
0.666 |
|
| 1991 |
Hirayama H, Pang KS. First-pass metabolism of gentisamide: influence of intestinal metabolism on hepatic formation of conjugates. Studies in the once-through vascularly perfused rat intestine-liver preparation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 18: 580-7. PMID 1981705 |
0.302 |
|
| 1990 |
St-Pierre MV, van den Berg D, Pang KS. Physiological modeling of drug and metabolite: Disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation Journal of Pharmacokinetics and Biopharmaceutics. 18: 423-448. PMID 2266497 DOI: 10.1007/BF01061703 |
0.305 |
|
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