Gloria M. Coruzzi, Ph.D
Affiliations: | 1984-1991 | Lab of Plant Molecular Biology | Rockefeller University, New York, NY, United States |
1991- | Center for Genomics & Systems Biology | New York University, New York, NY, United States |
Area:
Plant Systems BiologyWebsite:
http://coruzzilab.bio.nyu.edu/Google:
"Gloria Coruzzi"Bio:
http://www.nasonline.org/member-directory/members/20044143.html
https://as.nyu.edu/content/dam/nyu-as/faculty/documents/coruzzi-gloria-cv.pdf
https://scholar.google.com/citations?user=UVuQeJIAAAAJ&hl=en
Bio-sketch: (also see Wikipedia https://en.wikipedia.org/wiki/Gloria_M._Coruzzi).
Dr. Coruzzi is currently the Carroll & Milton Petrie Professor at New York University’s Center for Genomics and Systems Biology. Her research in Plant Systems Biology combines genomic, bioinformatic, and system biology approaches to identify gene networks involved in biological regulatory mechanisms controlling nitrogen use efficiency. A native New Yorker, Dr. Coruzzi received her Ph.D. in Molecular & Cell Biology at New York University School of Medicine in yeast genetics, where she decoded the yeast mitochondrial genome. These studies revealed that TGA codes for tryptophan in yeast mitochondria, a discovery subsequently found in humans. As post-doctoral fellow at Rockefeller University (1980-83), she began studies of plant molecular biology by cloning one of the first plant nuclear genes. As an Assistant and then Associate Professor at Rockefeller University, Dr. Coruzzi began her studies of the genes in the nitrogen assimilatory pathway. Since joining NYU as the Carroll & Milton Petrie Professor of Biology in 1991, Dr. Coruzzi’s lab has initiated genomic and systems biology approaches in Arabidopsis and crop species to study gene regulatory networks underlying Nitrogen Use Efficiency. This work has included the development of new bioinformatic and systems biology approaches. The over-arching achievement of Dr. Coruzzi’s research has been to develop Systems Biology approaches to predictively model how internal and external perturbations affect processes, pathways & networks controlling plant metabolism, growth and development. Her current studies exploit time - the 4th and largely unexplored dimension of transcriptional networks - to temporally perturb TF function and to predict and validate dynamic gene regulatory (GRNs) models that can forecast network states at future time-points, a major goal of systems biology. Dr. Coruzzi’s system biology studies involve collaborations with colleagues at NYU Courant Institute for Math & Computer Science. Dr. Coruzzi is also engaged in a collaborative NSF Plant Genome Project on the Comparative Genomics of Seed Evolution with co-PIs at the New York Botanical Garden, the American Museum of Natural History, and Cold Spring Harbor labs. Dr. Coruzzi’s research is funded by the National Institutes of Health, the NSF Plant Genome Program, the Department of Energy and the Zegar Family Foundation. Dr. Coruzzi was named an American Association for the Advancement of Science Fellow in 2005, a Fellow of the American Society of Plant Biology in 2010, was awarded the ASPB Stephen Hales Prize in 2015, was named Distinguished Counselor to the Board, The New York Botanical Garden in 2017, and was elected to the National Academy of Sciences, Plant Biology Section in 2019. Coruzzi currently serves on several science editorial boards including; The Proceedings of the National Academy of Science, G3: Genes, Genomes and Genetics, and scientific advisory boards including the DOE Joint Genome Institute (JGI) Scientific Advisory Committee and their Plant Program Advisory Board. In addition to her research, Prof. Coruzzi is devoted to mentoring undergraduate and high school STEM students to apply computational approaches to biology.
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Parents
Sign in to add mentorAlexander Tzagoloff | grad student | 1976-1979 | NYU School of Medicine (Chemistry Tree) | |
(Genetic and biochemical analysis of mitochondrial DNA) | ||||
Nam-Hai Chua | post-doc | 1980-1983 | Rockefeller |
Children
Sign in to add traineeCollaborators
Sign in to add collaboratorRob DeSalle | collaborator | American Museum of Natural History (FlyTree) | |
Rodrigo Gutierrez | collaborator | P Universidad Catolica de Chile | |
Gabriel Krouk | collaborator | B&PMP Montpellier | |
R.W. McCombie | collaborator | CSHL | |
Stephen Moose | collaborator | UIUC (Cell Biology Tree) | |
Sandrine Ruffel | collaborator | B&PMP Montpellier | |
Dennis Shasha | collaborator | NYU Courant (Computational Biology Tree) | |
Dennis William Stevenson | collaborator | New York Botanical Garden (Evolution Tree) |
Publications
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Hinckley WE, Jack A, Li A, et al. (2025) Transcription Factor (TF) validation using Dam-IT simultaneously captures genome-wide TF-DNA binding, direct gene regulation, and chromatin accessibility in plant cells. Biorxiv : the Preprint Server For Biology |
Ruffel S, Del Rosario J, Lacombe B, et al. (2025) Nitrate Sensing and Signaling in Plants: Comparative Insights and Nutritional Interactions. Annual Review of Plant Biology. 76: 25-52 |
Huang J, Cheng CY, Brooks MD, et al. (2025) NUE regulons conserved model-to-crop enhance machine learning predictions of nitrogen use efficiency. The Plant Cell |
Salinas NR, Eshel G, Coruzzi GM, et al. (2024) BAD2matrix: Phylogenomic matrix concatenation, indel coding, and more. Applications in Plant Sciences. 12: e11604 |
Shen B, Coruzzi GM, Shasha D. (2024) Corrigendum: Bipartite networks represent causality better than simple networks: Evidence, algorithms, and applications. Frontiers in Genetics. 15: 1440665 |
Dussarrat T, Nilo-Poyanco R, Moyano TC, et al. (2024) Phylogenetically diverse wild plant species use common biochemical strategies to thrive in the Atacama Desert. Journal of Experimental Botany |
Shanks CM, Rothkegel K, Brooks MD, et al. (2024) Nitrogen sensing and regulatory networks: It's about time and space. The Plant Cell |
Coruzzi GM, Birnbaum KD. (2023) Philip N. Benfey (1953-2023). Science (New York, N.Y.). 382: 1127 |
Raikhel N, Ecker JR, Coruzzi G. (2023) Remembering Philip N. Benfey: A visionary pioneer in plant biology and mentor extraordinaire. Proceedings of the National Academy of Sciences of the United States of America. 120: e2317677120 |
Huang J, Katari MS, Juang CL, et al. (2023) Building High-Confidence Gene Regulatory Networks by Integrating Validated TF-Target Gene Interactions Using ConnecTF. Methods in Molecular Biology (Clifton, N.J.). 2698: 195-220 |