Lea Harrington - Publications

Affiliations: 
Cell Biology University of Edinburgh, Edinburgh, Scotland, United Kingdom 
Website:
http://www.wcb.ed.ac.uk/harrington

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sun C, Wang K, Stock AJ, Gong Y, Demarest TG, Yang B, Giri N, Harrington L, Alter BP, Savage SA, Bohr VA, Liu Y. Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. The Embo Journal. e103420. PMID 32935380 DOI: 10.15252/Embj.2019103420  0.92
2018 Monaghan P, Eisenberg DTA, Harrington L, Nussey D. Understanding diversity in telomere dynamics. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29335374 DOI: 10.1098/Rstb.2016.0435  0.64
2015 Fairlie J, Holland R, Pilkington JG, Pemberton JM, Harrington L, Nussey DH. Lifelong leukocyte telomere dynamics and survival in a free-living mammal. Aging Cell. PMID 26521726 DOI: 10.1111/Acel.12417  1
2015 McWilliams IL, Rajbhandari R, Nozell S, Benveniste E, Harrington LE. STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE. Journal of Neuroinflammation. 12: 128. PMID 26123499 DOI: 10.1186/S12974-015-0351-3  0.4
2015 Vallabhaneni H, Zhou F, Maul RW, Sarkar J, Yin J, Lei M, Harrington L, Gearhart PJ, Liu Y. Defective repair of uracil causes telomere defects in mouse hematopoietic cells. The Journal of Biological Chemistry. 290: 5502-11. PMID 25572391 DOI: 10.1074/Jbc.M114.607101  1
2015 Fairlie J, Harrington L. Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation. Dna Repair. 25: 54-9. PMID 25484304 DOI: 10.1016/j.dnarep.2014.11.005  1
2014 Arat NO, Harrington L. Targeted protein degradation as a tumor suppressor. Cell Cycle (Georgetown, Tex.). 13: 3473. PMID 25493413 DOI: 10.4161/15384101.2014.980700  1
2014 Vasianovich Y, Harrington LA, Makovets S. Break-induced replication requires DNA damage-induced phosphorylation of Pif1 and leads to telomere lengthening. Plos Genetics. 10: e1004679. PMID 25329304 DOI: 10.1371/journal.pgen.1004679  1
2014 Zajac AJ, Harrington LE. Tissue-resident T cells lose their S1P1 exit visas. Cellular & Molecular Immunology. 11: 221-3. PMID 24561454 DOI: 10.1038/Cmi.2014.7  0.4
2014 Beurel E, Harrington LE, Buchser W, Lemmon V, Jope RS. Astrocytes modulate the polarization of CD4+ T cells to Th1 cells. Plos One. 9: e86257. PMID 24489707 DOI: 10.1371/Journal.Pone.0086257  0.4
2014 Yeh WI, McWilliams IL, Harrington LE. IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms. Journal of Neuroimmunology. 267: 20-7. PMID 24369297 DOI: 10.1016/J.Jneuroim.2013.12.001  0.4
2014 Liu Y, Holdbrooks AT, De Sarno P, Rowse AL, Yanagisawa LL, McFarland BC, Harrington LE, Raman C, Sabbaj S, Benveniste EN, Qin H. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 192: 59-72. PMID 24323580 DOI: 10.4049/Jimmunol.1301513  0.4
2014 Zajac AJ, Harrington LE. Immune Response to Viruses: Cell-Mediated Immunity Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.02604-0  0.4
2013 Mollo SB, Ingram JT, Kress RL, Zajac AJ, Harrington LE. Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors. Journal of Leukocyte Biology. PMID 24231259 DOI: 10.1189/Jlb.0813429  0.4
2013 Mollo SB, Zajac AJ, Harrington LE. Temporal requirements for B cells in the establishment of CD4 T cell memory. Journal of Immunology (Baltimore, Md. : 1950). 191: 6052-9. PMID 24218454 DOI: 10.4049/Jimmunol.1302033  0.4
2013 Gardano L, Pucci F, Christian L, Le Bihan T, Harrington L. Telomeres, a busy platform for cell signaling. Frontiers in Oncology. 3: 146. PMID 23772418 DOI: 10.3389/fonc.2013.00146  1
2013 Beurel E, Kaidanovich-Beilin O, Yeh WI, Song L, Palomo V, Michalek SM, Woodgett JR, Harrington LE, Eldar-Finkelman H, Martinez A, Jope RS. Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3. Journal of Immunology (Baltimore, Md. : 1950). 190: 5000-11. PMID 23606540 DOI: 10.4049/Jimmunol.1203057  0.4
2013 Pucci F, Gardano L, Harrington L. Short telomeres in ESCs lead to unstable differentiation. Cell Stem Cell. 12: 479-86. PMID 23561444 DOI: 10.1016/j.stem.2013.01.018  1
2013 Wong LH, Unciti-Broceta A, Spitzer M, White R, Tyers M, Harrington L. A yeast chemical genetic screen identifies inhibitors of human telomerase. Chemistry & Biology. 20: 333-40. PMID 23521791 DOI: 10.1016/J.Chembiol.2012.12.008  1
2013 Patton EE, Harrington L. Cancer: Trouble upstream. Nature. 495: 320-1. PMID 23518559 DOI: 10.1038/495320a  1
2013 Beurel E, Harrington LE, Jope RS. Inflammatory T helper 17 cells promote depression-like behavior in mice. Biological Psychiatry. 73: 622-30. PMID 23174342 DOI: 10.1016/J.Biopsych.2012.09.021  0.4
2012 Taboski MA, Sealey DC, Dorrens J, Tayade C, Betts DH, Harrington L. Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis. Cell Reports. 1: 91-8. PMID 22832159 DOI: 10.1016/J.Celrep.2011.12.004  1
2012 Qin H, Yeh WI, De Sarno P, Holdbrooks AT, Liu Y, Muldowney MT, Reynolds SL, Yanagisawa LL, Fox TH, Park K, Harrington LE, Raman C, Benveniste EN. Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 109: 5004-9. PMID 22411837 DOI: 10.1073/Pnas.1117218109  0.4
2012 Gardano L, Holland L, Oulton R, Le Bihan T, Harrington L. Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin. Nucleic Acids Research. 40: e36. PMID 22187156 DOI: 10.1093/nar/gkr1243  1
2012 Harrington L. Haploinsufficiency and telomere length homeostasis. Mutation Research. 730: 37-42. PMID 22100521 DOI: 10.1016/j.mrfmmm.2011.11.004  1
2012 Liu Y, Harrington L. Murine Models of Dysfunctional Telomeres and Telomerase Telomerases: Chemistry, Biology, and Clinical Applications. 213-242. DOI: 10.1002/9781118268667.ch9  1
2011 Sealey DC, Kostic AD, LeBel C, Pryde F, Harrington L. The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis. Bmc Molecular Biology. 12: 45. PMID 22011238 DOI: 10.1186/1471-2199-12-45  1
2011 Yeh WI, McWilliams IL, Harrington LE. Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 187: 4998-5006. PMID 21984703 DOI: 10.4049/Jimmunol.1100031  0.4
2011 Reynolds GE, Gao Q, Miller D, Snow BE, Harrington LA, Murnane JP. PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells. Dna Repair. 10: 1164-73. PMID 21945094 DOI: 10.1016/j.dnarep.2011.09.002  1
2011 Cox MA, Harrington LE, Zajac AJ. Cytokines and the inception of CD8 T cell responses. Trends in Immunology. 32: 180-6. PMID 21371940 DOI: 10.1016/J.It.2011.01.004  0.4
2010 Rashid-Kolvear F, Taboski MA, Nguyen J, Wang DY, Harrington LA, Done SJ. Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. Bmc Cancer. 10: 390. PMID 20650001 DOI: 10.1186/1471-2407-10-390  1
2010 Sealey DC, Zheng L, Taboski MA, Cruickshank J, Ikura M, Harrington LA. The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. Nucleic Acids Research. 38: 2019-35. PMID 20034955 DOI: 10.1093/nar/gkp1160  1
2010 Gardano L, Harrington L. Telomere biology and biochemistry Cellular Senescence and Tumor Suppression. 3-43. DOI: 10.1007/978-1-4419-1075-2_1  1
2009 Meznikova M, Erdmann N, Allsopp R, Harrington LA. Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes. Disease Models & Mechanisms. 2: 620-6. PMID 19841238 DOI: 10.1242/dmm.004069  1
2009 Lebel C, Rosonina E, Sealey DC, Pryde F, Lydall D, Maringele L, Harrington LA. Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52. Genetics. 182: 671-84. PMID 19380905 DOI: 10.1534/Genetics.109.102939  1
2009 Erdmann N, Harrington LA. No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells. Dna Repair. 8: 347-53. PMID 19071232 DOI: 10.1016/j.dnarep.2008.11.009  1
2007 Snow BE, Mateyak M, Paderova J, Wakeham A, Iorio C, Zakian V, Squire J, Harrington L. Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Molecular and Cellular Biology. 27: 1017-26. PMID 17130244 DOI: 10.1128/Mcb.01866-06  1
2006 Betts DH, Perrault S, Harrington L, King WA. Quantitative analysis of telomerase activity and telomere length in domestic animal clones. Methods in Molecular Biology (Clifton, N.J.). 325: 149-80. PMID 16761726 DOI: 10.1385/1-59745-005-7:149  1
2006 Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann N, Binné UK, Harrington L, Sicinski P, Bérubé NG, Dyson NJ, Dick FA. The retinoblastoma protein regulates pericentric heterochromatin. Molecular and Cellular Biology. 26: 3659-71. PMID 16612004 DOI: 10.1128/Mcb.26.9.3659-3671.2006  1
2006 Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell. 124: 1155-68. PMID 16564010 DOI: 10.1016/J.Cell.2005.12.044  1
2006 Ungrin MD, Harrington L. Strict control of telomerase activation using Cre-mediated inversion. Bmc Biotechnology. 6: 10. PMID 16504006 DOI: 10.1186/1472-6750-6-10  1
2005 Goldman F, Bouarich R, Kulkarni S, Freeman S, Du HY, Harrington L, Mason PJ, Londoño-Vallejo A, Bessler M. The effect of TERC haploinsufficiency on the inheritance of telomere length. Proceedings of the National Academy of Sciences of the United States of America. 102: 17119-24. PMID 16284252 DOI: 10.1073/Pnas.0505318102  1
2005 Wang JCY, Warner JK, Erdmann N, Lansdorp PM, Harrington L, Dick JE. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 102: 14398-14403. PMID 16172394 DOI: 10.1073/Pnas.0504161102  1
2005 Harrington L. Making the most of a little: dosage effects in eukaryotic telomere length maintenance. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 13: 493-504. PMID 16132814 DOI: 10.1007/S10577-005-0994-5  1
2005 Warner JK, Wang JC, Takenaka K, Doulatov S, McKenzie JL, Harrington L, Dick JE. Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells. Leukemia. 19: 1794-805. PMID 16094415 DOI: 10.1038/sj.leu.2403917  1
2005 Poderycki MJ, Rome LH, Harrington L, Kickhoefer VA. The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic Acids Research. 33: 893-902. PMID 15701761 DOI: 10.1093/nar/gki234  1
2004 Mikyas Y, Makabi M, Raval-Fernandes S, Harrington L, Kickhoefer VA, Rome LH, Stewart PL. Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP. Journal of Molecular Biology. 344: 91-105. PMID 15504404 DOI: 10.1016/J.Jmb.2004.09.021  1
2004 Harrington L. Does the reservoir for self-renewal stem from the ends? Oncogene. 23: 7283-9. PMID 15378088 DOI: 10.1038/Sj.Onc.1207948  1
2004 Edmonds D, Breitkreutz BJ, Harrington L. A genome-wide telomere screen in yeast: the long and short of it all. Proceedings of the National Academy of Sciences of the United States of America. 101: 9515-6. PMID 15213325 DOI: 10.1073/Pnas.0403378101  1
2004 Liu Y, Snow BE, Kickhoefer VA, Erdmann N, Zhou W, Wakeham A, Gomez M, Rome LH, Harrington L. Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Molecular and Cellular Biology. 24: 5314-23. PMID 15169895 DOI: 10.1128/Mcb.24.12.5314-5323.2004  1
2004 Oulton R, Harrington L. A human telomerase-associated nuclease. Molecular Biology of the Cell. 15: 3244-56. PMID 15121883 DOI: 10.1091/Mbc.E04-03-0178  1
2004 Harrington L. Those dam-aged telomeres! Current Opinion in Genetics & Development. 14: 22-8. PMID 15108801 DOI: 10.1016/J.Gde.2003.12.007  1
2004 Erdmann N, Liu Y, Harrington L. Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 6080-5. PMID 15079066 DOI: 10.1073/Pnas.0401580101  1
2003 Harrington L. Biochemical aspects of telomerase function. Cancer Letters. 194: 139-54. PMID 12757972 DOI: 10.1016/S0304-3835(02)00701-2  1
2003 Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L. Functional conservation of the telomerase protein Est1p in humans. Current Biology : Cb. 13: 698-704. PMID 12699629 DOI: 10.1016/S0960-9822(03)00210-0  1
2002 Liu Y, Kha H, Ungrin M, Robinson MO, Harrington L. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proceedings of the National Academy of Sciences of the United States of America. 99: 3597-602. PMID 11904422 DOI: 10.1073/Pnas.062549199  1
2002 Harrington L, Robinson MO. Telomere dysfunction: multiple paths to the same end. Oncogene. 21: 592-7. PMID 11850784 DOI: 10.1038/Sj.Onc.1205084  1
2001 Beattie TL, Zhou W, Robinson MO, Harrington L. Functional multimerization of the human telomerase reverse transcriptase. Molecular and Cellular Biology. 21: 6151-60. PMID 11509658 DOI: 10.1128/Mcb.21.18.6151-6160.2001  1
2001 Kickhoefer VA, Liu Y, Kong LB, Snow BE, Stewart PL, Harrington L, Rome LH. The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. The Journal of Cell Biology. 152: 157-64. PMID 11149928 DOI: 10.1083/Jcb.152.1.157  1
2001 Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. Erratum: The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo (Current Biology (2000) 10:22 (1459-1462)) Current Biology. 11. DOI: 10.1016/S0960-9822(01)00264-0  0.92
2000 Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Current Biology : Cb. 10: 1459-62. PMID 11102810 DOI: 10.1016/S0960-9822(00)00805-8  1
2000 Beattie TL, Zhou W, Robinson MO, Harrington L. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Molecular Biology of the Cell. 11: 3329-40. PMID 11029039 DOI: 10.1091/Mbc.11.10.3329  1
2000 Liu Y, Snow BE, Hande MP, Baerlocher G, Kickhoefer VA, Yeung D, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Molecular and Cellular Biology. 20: 8178-84. PMID 11027287 DOI: 10.1128/Mcb.20.21.8178-8184.2000  1
2000 Oulton R, Harrington L. Telomeres, telomerase, and cancer: Life on the edge of genomic stability Current Opinion in Oncology. 12: 74-81. PMID 10687733 DOI: 10.1097/00001622-200001000-00013  1
1999 Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH. Vaults and telomerase share a common subunit, TEP1 Journal of Biological Chemistry. 274: 32712-32717. PMID 10551828 DOI: 10.1074/jbc.274.46.32712  1
1999 Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells Genes and Development. 13: 2388-2399. PMID 10500096 DOI: 10.1101/Gad.13.18.2388  1
1998 Beattie TL, Zhou W, Robinson MO, Harrington L. Reconstitution of human telomerase activity in vitro. Current Biology : Cb. 8: 177-80. PMID 9443919 DOI: 10.1016/S0960-9822(98)70067-3  1
1997 Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes & Development. 11: 3109-15. PMID 9389643 DOI: 10.1101/Gad.11.23.3109  1
1997 Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO. A mammalian telomerase-associated protein. Science (New York, N.Y.). 275: 973-7. PMID 9020079 DOI: 10.1126/Science.275.5302.973  1
1996 Harrington LA, Andrews BJ. Binding to the yeast SwI4,6-dependent cell cycle box, CACGAAA, is cell cycle regulated in vivo. Nucleic Acids Research. 24: 558-65. PMID 8604294 DOI: 10.1093/nar/24.4.558  1
1995 Harrington L, Hull C, Crittenden J, Greider C. Gel shift and UV cross-linking analysis of Tetrahymena telomerase. The Journal of Biological Chemistry. 270: 8893-901. PMID 7721797 DOI: 10.1074/Jbc.270.15.8893  1
1992 Avilion AA, Harrington LA, Greider CW. Tetrahymena telomerase RNA levels increase during macronuclear development. Developmental Genetics. 13: 80-6. PMID 1395145 DOI: 10.1002/Dvg.1020130113  1
1991 Harrington LA, Greider CW. Telomerase primer specificity and chromosome healing. Nature. 353: 451-4. PMID 1896088 DOI: 10.1016/0962-8924(92)90136-B  1
1991 Harrington L, Klintworth GK, Secor TE, Breitman ML. Developmental analysis of ocular morphogenesis in alpha A-crystallin/diphtheria toxin transgenic mice undergoing ablation of the lens. Developmental Biology. 148: 508-16. PMID 1743399 DOI: 10.1016/0012-1606(91)90269-9  1
1988 Harrington LA, Harley CB. Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mechanisms of Ageing and Development. 43: 71-8. PMID 3374177 DOI: 10.1016/0047-6374(88)90098-X  1
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