| Year |
Citation |
Score |
| 2024 |
Vu LY, Luo D, Johnson K, Denehy ED, Songrady JC, Martin J, Trivedi R, Alsum AR, Shaykin JD, Chaudhary CL, Woloshin EJ, Kornberger L, Bhuiyan N, Parkin S, Jiang Q, ... ... Prisinzano TE, et al. Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression. Journal of Medicinal Chemistry. PMID 38810170 DOI: 10.1021/acs.jmedchem.4c00333 |
0.417 |
|
| 2024 |
Roth HG, Das M, Sulima A, Luo D, Kaska S, Prisinzano TE, Kerr AT, Jacobson AE, Rice KC. Functional Activity of Enantiomeric Oximes and Diastereomeric Amines and Cyano Substituents at C9 in 3-Hydroxy--phenethyl-5-phenylmorphans. Molecules (Basel, Switzerland). 29. PMID 38731416 DOI: 10.3390/molecules29091926 |
0.408 |
|
| 2023 |
Zamarripa CA, Huskinson SL, Townsend EA, Prisinzano TE, Blough BE, Rowlett JK, Freeman KB. Contingent administration of typical and biased kappa opioid agonists reduces cocaine and oxycodone choice in a drug vs. food choice procedure in male rhesus monkeys. Psychopharmacology. PMID 37870564 DOI: 10.1007/s00213-023-06486-5 |
0.406 |
|
| 2023 |
Huskinson SL, Platt DM, Smith ZR, Doyle WS, Zamarripa CA, Dunaway K, Prisinzano TE, Freeman KB. Quantification of observable behaviors following oral administration of oxycodone and nalfurafine in male rhesus monkeys. Drug and Alcohol Dependence. 252: 110953. PMID 37734282 DOI: 10.1016/j.drugalcdep.2023.110953 |
0.373 |
|
| 2023 |
Chambers DR, Sulima A, Luo D, Prisinzano TE, Jacobson AE, Rice KC. A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted -Phenethyl-5-(3-hydroxy)phenylmorphans. Molecules (Basel, Switzerland). 28. PMID 37513283 DOI: 10.3390/molecules28145411 |
0.41 |
|
| 2023 |
van de Wetering R, Ewald A, Welsh S, Kornberger L, Williamson SE, McElroy BD, Butelman ER, Prisinzano TE, Kivell BM. The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors. Molecules (Basel, Switzerland). 28. PMID 37375403 DOI: 10.3390/molecules28124848 |
0.314 |
|
| 2023 |
Lutz JA, Sulima A, Gutman ES, Bow EW, Luo D, Kaska S, Prisinzano TE, Paronis CA, Bergman J, Imler GH, Kerr AT, Jacobson AE, Rice KC. Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans. Molecules (Basel, Switzerland). 28. PMID 37375350 DOI: 10.3390/molecules28124795 |
0.359 |
|
| 2022 |
Chambers DR, Sulima A, Luo D, Prisinzano TE, Goldberg A, Xie B, Shi L, Paronis CA, Bergman J, Nassehi N, Selley DE, Imler GH, Jacobson AE, Rice KC. A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists. Molecules (Basel, Switzerland). 27. PMID 36234992 DOI: 10.3390/molecules27196455 |
0.384 |
|
| 2022 |
Shelton CL, Meneely KM, Ronnebaum TA, Chilton AS, Riley AP, Prisinzano TE, Lamb AL. Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 35513576 DOI: 10.1007/s00775-022-01941-8 |
0.759 |
|
| 2022 |
Huskinson SL, Platt DM, Zamarripa CA, Dunaway K, Brasfield M, Prisinzano TE, Blough BE, Freeman KB. The G-protein biased kappa opioid agonists, triazole 1.1 and nalfurafine, produce non-uniform behavioral effects in male rhesus monkeys. Pharmacology, Biochemistry, and Behavior. 217: 173394. PMID 35513117 DOI: 10.1016/j.pbb.2022.173394 |
0.37 |
|
| 2022 |
Paton KF, Luo D, La Flamme AC, Prisinzano TE, Kivell BM. Sex Differences in Kappa Opioid Receptor Agonist Mediated Attenuation of Chemotherapy-Induced Neuropathic Pain in Mice. Frontiers in Pharmacology. 13: 813562. PMID 35250563 DOI: 10.3389/fphar.2022.813562 |
0.316 |
|
| 2021 |
Hedrick SL, Luo D, Kaska S, Niloy KK, Jackson K, Sarma R, Horn J, Baynard C, Leggas M, Butelman ER, Kreek MJ, Prisinzano TE. Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent. Journal of Biomedical Science. 28: 62. PMID 34503531 DOI: 10.1186/s12929-021-00758-y |
0.371 |
|
| 2021 |
Zamarripa CA, Pareek T, Schrock HM, Prisinzano TE, Blough BE, Sufka KJ, Freeman KB. The kappa-opioid receptor agonist, triazole 1.1, reduces oxycodone self-administration and enhances oxycodone-induced thermal antinociception in male rats. Psychopharmacology. PMID 34430992 DOI: 10.1007/s00213-021-05965-x |
0.437 |
|
| 2021 |
Butelman ER, Baynard C, McElroy BD, Prisinzano TE, Kreek MJ. Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice. Journal of Psychopharmacology (Oxford, England). 269881121996883. PMID 33769112 DOI: 10.1177/0269881121996883 |
0.366 |
|
| 2020 |
Gutman ES, Bow E, Li F, Sulima A, Kaska S, Crowley R, Prisinzano TE, Lee YS, Hassan SA, Imler GH, Deschamps JR, Jacobson AE, Rice KC. G-Protein biased opioid agonists: 3-hydroxy--phenethyl-5-phenylmorphans with three-carbon chain substituents at C9. Rsc Medicinal Chemistry. 11: 896-904. PMID 33479684 DOI: 10.1039/d0md00104j |
0.382 |
|
| 2020 |
Paton K, Atigari D, Kaska S, Prisinzano TE, Kivell BM. . The Journal of Pharmacology and Experimental Therapeutics. PMID 32913006 DOI: 10.1124/Jpet.120.000134 |
0.527 |
|
| 2020 |
Zamarripa CA, Patel TR, Williams BC, Pareek T, Schrock HM, Prisinzano TE, Freeman KB. The kappa-opioid receptor agonist, nalfurafine, blocks acquisition of oxycodone self-administration and oxycodone's conditioned rewarding effects in male rats. Behavioural Pharmacology. PMID 32804774 DOI: 10.1097/Fbp.0000000000000581 |
0.353 |
|
| 2020 |
Paton KF, Biggerstaff A, Kaska S, Crowley RS, La Flamme AC, Prisinzano TE, Kivell BM. Evaluation of Biased and Balanced Salvinorin A Analogs in Preclinical Models of Pain. Frontiers in Neuroscience. 14: 765. PMID 32792903 DOI: 10.3389/Fnins.2020.00765 |
0.458 |
|
| 2020 |
Wang M, Irvin TC, Herdman CA, Hanna RD, Hassan SA, Lee YS, Kaska S, Crowley RS, Prisinzano TE, Withey SL, Paronis CA, Bergman J, Inan S, Geller EB, Adler MW, et al. The Intriguing Effects of Substituents in the -Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments. Molecules (Basel, Switzerland). 25. PMID 32517185 DOI: 10.3390/Molecules25112640 |
0.838 |
|
| 2020 |
Crowley RS, Riley AP, Alder AF, Anderson Iii RJ, Luo D, Kaska S, Maynez P, Kivell BM, Prisinzano TE. Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ Opioid Receptor. Acs Chemical Neuroscience. PMID 32383854 DOI: 10.1021/Acschemneuro.0C00191 |
0.778 |
|
| 2020 |
Huskinson SL, Platt DM, Brasfield M, Follett ME, Prisinzano TE, Blough BE, Freeman KB. Quantification of observable behaviors induced by typical and atypical kappa-opioid receptor agonists in male rhesus monkeys. Psychopharmacology. PMID 32372348 DOI: 10.1007/S00213-020-05519-7 |
0.531 |
|
| 2020 |
Zamarripa CA, Naylor JE, Huskinson SL, Townsend EA, Prisinzano TE, Freeman KB. Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys. Psychopharmacology. PMID 32006048 DOI: 10.1007/S00213-020-05473-4 |
0.491 |
|
| 2019 |
Hunt JR, Kleindl PA, Moulder KR, Prisinzano TE, Forrest ML. Further exploration of the structure-activity relationship of imidazoquinolines; identification of potent C7-substituted imidazoquinolines. Bioorganic & Medicinal Chemistry Letters. 126788. PMID 31784317 DOI: 10.1016/J.Bmcl.2019.126788 |
0.379 |
|
| 2019 |
Kaski SW, White AN, Gross JD, Trexler KR, Wix K, Harland AA, Prisinzano TE, Aube J, Kinsey SG, Kenakin T, Siderovski D, Setola V. Preclinical testing of nalfurafine as an opioid-sparing adjuvant that potentiates analgesia by the mu opioid receptor-targeting agonist morphine. The Journal of Pharmacology and Experimental Therapeutics. PMID 31492823 DOI: 10.1124/Jpet.118.255661 |
0.498 |
|
| 2019 |
Butelman ER, McElroy BD, Prisinzano TE, Kreek MJ. Impact of Pharmacological Manipulation of the -Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice. The Journal of Pharmacology and Experimental Therapeutics. 370: 1-8. PMID 30975792 DOI: 10.1124/jpet.119.256354 |
0.357 |
|
| 2018 |
Ronnebaum TA, McFarlane JS, Prisinzano TE, Booker SJ, Lamb AL. Stuffed Methyltransferase Catalyzes Penultimate Step of Pyochelin Biosynthesis. Biochemistry. PMID 30525512 DOI: 10.1021/Acs.Biochem.8B00716 |
0.756 |
|
| 2018 |
Kivell BM, Paton KF, Kumar N, Morani AS, Culverhouse A, Shepherd A, Welsh SA, Biggerstaff A, Crowley RS, Prisinzano TE. Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents. Molecules (Basel, Switzerland). 23. PMID 30314288 DOI: 10.3390/Molecules23102602 |
0.375 |
|
| 2018 |
Tai S, Vasiljevik T, Sherwood AM, Eddington S, Wilson CD, Prisinzano TE, Fantegrossi WE. Assessment of rimonabant-like adverse effects of purported CB1R neutral antagonist / CB2R agonist aminoalkylindole derivatives in mice. Drug and Alcohol Dependence. 192: 285-293. PMID 30300803 DOI: 10.1016/J.Drugalcdep.2018.08.011 |
0.676 |
|
| 2018 |
Zhou Y, Crowley R, Prisinzano T, Kreek MJ. Effects of Mesyl Salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice. Neuroscience Letters. PMID 29496608 DOI: 10.1016/J.Neulet.2018.02.056 |
0.321 |
|
| 2017 |
Sherwood AM, Williamson SE, Crowley RS, Abbott LM, Day VW, Prisinzano TE. Modular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands. Organic Letters. PMID 28910112 DOI: 10.1021/Acs.Orglett.7B02684 |
0.515 |
|
| 2017 |
Yilmaz A, Crowley RS, Sherwood AM, Prisinzano TE. Semisynthesis and Kappa-Opioid Receptor Activity of Derivatives of Columbin, a Furanolactone Diterpene. Journal of Natural Products. PMID 28718638 DOI: 10.1021/Acs.Jnatprod.7B00327 |
0.488 |
|
| 2017 |
Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Correction to "Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias". Acs Chemical Neuroscience. PMID 28541028 DOI: 10.1021/acschemneuro.7b00157 |
0.826 |
|
| 2017 |
Ewald AWM, Bosch PJ, Culverhouse A, Crowley RS, Neuenswander B, Prisinzano TE, Kivell BM. The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal B and β-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects. Psychopharmacology. PMID 28536865 DOI: 10.1007/S00213-017-4637-2 |
0.44 |
|
| 2017 |
Sherwood AM, Crowley RS, Paton KF, Biggerstaff A, Neuenswander B, Day VW, Kivell BM, Prisinzano TE. Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa Opioid Agonist with Enhanced Metabolic Stability. Journal of Medicinal Chemistry. PMID 28376298 DOI: 10.1021/Acs.Jmedchem.7B00148 |
0.477 |
|
| 2017 |
Karad SN, Pal M, Prisinzano TE, Crowley RS, Altman RA. Synthesis and Opioid Activity of Tyr1-[(Z)CF=CH]-Gly2 and Tyr1-[(S)/(R)-CF3CH-NH]-Gly2 Leu-enkephalin Fluorinated Pep-tidomimetics. Chemmedchem. PMID 28296145 DOI: 10.1002/Cmdc.201700103 |
0.466 |
|
| 2017 |
Zhou Y, Cowley RS, Ben K, Prisinzano TE, Kreek MJ. Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone. Brain Research. PMID 28263712 DOI: 10.1016/J.Brainres.2017.02.027 |
0.36 |
|
| 2017 |
Paton KF, Kumar N, Crowley RS, Harper JL, Prisinzano TE, Kivell BM. The analgesic and anti-inflammatory effects of Salvinorin A analogue β-tetrahydropyran Salvinorin B in mice. European Journal of Pain (London, England). PMID 28158929 DOI: 10.1002/Ejp.1002 |
0.489 |
|
| 2017 |
Kivell BM, Young D, Culverhouse A, Prisinzano T. Kappa opioid receptor agonist 16-ethynyl salvinorin a attenuates the rewarding effects of cocaine in the progressive ratio model in rats with fewer side-effects Drug and Alcohol Dependence. 171: e106. DOI: 10.1016/J.Drugalcdep.2016.08.297 |
0.463 |
|
| 2016 |
Crowley RS, Riley AP, Sherwood AM, Groer CE, Shivaperumal N, Biscaia M, Paton K, Schneider S, Provasi D, Kivell BM, Filizola M, Prisinzano TE. Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. Journal of Medicinal Chemistry. PMID 27958743 DOI: 10.1021/Acs.Jmedchem.6B01235 |
0.787 |
|
| 2016 |
Meneely KM, Ronnebaum TA, Riley AP, Prisinzano TE, Lamb AL. Holo-structure and steady state kinetics of the thiazolinyl imine reductases for siderophore biosynthesis. Biochemistry. PMID 27601130 DOI: 10.1021/Acs.Biochem.6B00735 |
0.761 |
|
| 2016 |
Mereu M, Chun LE, Prisinzano T, Newman AH, Katz JL, Tanda G. The Unique Psychostimulant Profile of (±)-Modafinil: Investigation of Behavioral and Neurochemical Effects in Mice. The European Journal of Neuroscience. PMID 27545285 DOI: 10.1111/Ejn.13376 |
0.508 |
|
| 2016 |
Johnson MW, MacLean KA, Caspers MJ, Prisinzano TE, Griffiths RR. Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans. Journal of Psychopharmacology (Oxford, England). PMID 26880225 DOI: 10.1177/0269881116629125 |
0.302 |
|
| 2016 |
Schneider S, Provasi D, Saylor R, Prisinzano T, Filizola M. Predicted mode of Binding of Non-Nitrogenous μ-Opioid Receptor Ligands by Metadynamics Biophysical Journal. 110: 90a. DOI: 10.1016/J.Bpj.2015.11.544 |
0.5 |
|
| 2015 |
Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus. Neuropharmacology. PMID 26318102 DOI: 10.1016/J.Neuropharm.2015.08.027 |
0.68 |
|
| 2015 |
Jamshidi RJ, Jacobs BA, Sullivan LC, Chavera TA, Saylor RM, Prisinzano TE, Clarke WP, Berg KA. Functional Selectivity of Kappa Opioid Receptor (KOR) Agonists in Peripheral Sensory Neurons. The Journal of Pharmacology and Experimental Therapeutics. PMID 26297384 DOI: 10.1124/Jpet.115.225896 |
0.388 |
|
| 2015 |
Zhou L, Stahl EL, Lovell KM, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting. Neuropharmacology. PMID 26160155 DOI: 10.1016/J.Neuropharm.2015.07.001 |
0.838 |
|
| 2015 |
Marchant NJ, Whitaker LR, Bossert JM, Harvey BK, Hope BT, Kaganovsky K, Adhikary S, Prisinzano TE, Vardy E, Roth BL, Shaham Y. Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26019014 DOI: 10.1038/Npp.2015.149 |
0.409 |
|
| 2015 |
Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias. Acs Chemical Neuroscience. PMID 25891774 DOI: 10.1021/Acschemneuro.5B00092 |
0.813 |
|
| 2015 |
Paranjape SR, Riley AP, Somoza AD, Oakley CE, Wang CC, Prisinzano TE, Oakley BR, Gamblin TC. Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro. Acs Chemical Neuroscience. 6: 751-60. PMID 25822288 DOI: 10.1021/Acschemneuro.5B00013 |
0.677 |
|
| 2015 |
Frankowski KJ, Slauson SR, Lovell KM, Phillips AM, Streicher JM, Zhou L, Whipple DA, Schoenen FJ, Prisinzano TE, Bohn LM, Aubé J. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif. Bioorganic & Medicinal Chemistry. 23: 3948-56. PMID 25593096 DOI: 10.1016/J.Bmc.2014.12.033 |
0.842 |
|
| 2015 |
Simonson B, Morani AS, Ewald AW, Walker L, Kumar N, Simpson D, Miller JH, Prisinzano TE, Kivell BM. Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. British Journal of Pharmacology. 172: 515-31. PMID 24641310 DOI: 10.1111/Bph.12692 |
0.532 |
|
| 2015 |
Kivell BM, Culverhouse A, Morani A, Prisinzano TE. Kappa opioid agonist Mesyl Sal B attenuates behavioral sensitization to cocaine with few side-effects Drug and Alcohol Dependence. 156: e114. DOI: 10.1016/J.Drugalcdep.2015.07.315 |
0.423 |
|
| 2015 |
Ewald A, Miller J, Prisinzano TE, Kivell BM. The kappa opioid receptor agonist 16-bromosalvinorin a reduces cocaine seeking in rats Drug and Alcohol Dependence. 156: e65. DOI: 10.1016/J.Drugalcdep.2015.07.1095 |
0.471 |
|
| 2015 |
Naylor J, Prisinzano T, Freeman K. Self-administration of oxycodone alone or as a mixture with the kappa agonist, salvinorin a, by monkeys under a progressive ratio schedule of reinforcement Drug and Alcohol Dependence. 146: e48-e49. DOI: 10.1016/J.Drugalcdep.2014.09.503 |
0.308 |
|
| 2014 |
Riley AP, Groer CE, Young D, Ewald AW, Kivell BM, Prisinzano TE. Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues. Journal of Medicinal Chemistry. 57: 10464-75. PMID 25426797 DOI: 10.1021/Jm501521D |
0.801 |
|
| 2014 |
Meneely KM, Luo Q, Riley AP, Taylor B, Roy A, Stein RL, Prisinzano TE, Lamb AL. Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism. Bioorganic & Medicinal Chemistry. 22: 5961-9. PMID 25282647 DOI: 10.1016/J.Bmc.2014.09.010 |
0.68 |
|
| 2014 |
Kivell B, Uzelac Z, Sundaramurthy S, Rajamanickam J, Ewald A, Chefer V, Jaligam V, Bolan E, Simonson B, Annamalai B, Mannangatti P, Prisinzano TE, Gomes I, Devi LA, Jayanthi LD, et al. Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology. 86: 228-40. PMID 25107591 DOI: 10.1016/J.Neuropharm.2014.07.016 |
0.344 |
|
| 2014 |
Vasiljevik T, Groer CE, Lehner K, Navarro H, Prisinzano TE. Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A. Journal of Natural Products. 77: 1817-24. PMID 25075762 DOI: 10.1021/Np5002048 |
0.385 |
|
| 2014 |
Kivell BM, Ewald AW, Prisinzano TE. Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse. Advances in Pharmacology (San Diego, Calif.). 69: 481-511. PMID 24484985 DOI: 10.1016/B978-0-12-420118-7.00012-3 |
0.547 |
|
| 2014 |
Freeman KB, Naylor JE, Prisinzano TE, Woolverton WL. Assessment of the kappa opioid agonist, salvinorin A, as a punisher of drug self-administration in monkeys. Psychopharmacology. 231: 2751-8. PMID 24481567 DOI: 10.1007/S00213-014-3436-2 |
0.432 |
|
| 2014 |
Freeman K, Prisinzano T, Woolverton W. The kappa agonist, salvinorin A, punishes remifentanil and cocaine self-administration in monkeys Drug and Alcohol Dependence. 140: e63. DOI: 10.1016/J.Drugalcdep.2014.02.191 |
0.318 |
|
| 2013 |
Caspers MJ, Williams TD, Lovell KM, Lozama A, Butelman ER, Kreek MJ, Johnson M, Griffiths R, Maclean K, Prisinzano TE. LC-MS/MS quantification of salvinorin A from biological fluids. Analytical Methods : Advancing Methods and Applications. 5. PMID 24416081 DOI: 10.1039/C3Ay40810H |
0.762 |
|
| 2013 |
Riley AP, Day VW, Navarro HA, Prisinzano TE. Palladium-catalyzed transformations of salvinorin A, a neoclerodane diterpene from Salvia divinorum. Organic Letters. 15: 5936-9. PMID 24246026 DOI: 10.1021/Ol4027528 |
0.699 |
|
| 2013 |
Morani AS, Ewald A, Prevatt-Smith KM, Prisinzano TE, Kivell BM. The 2-methoxy methyl analogue of salvinorin A attenuates cocaine-induced drug seeking and sucrose reinforcements in rats. European Journal of Pharmacology. 720: 69-76. PMID 24201308 DOI: 10.1016/J.Ejphar.2013.10.050 |
0.825 |
|
| 2013 |
Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl E, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aubé J, Bohn LM. Development of functionally selective, small molecule agonists at kappa opioid receptors. The Journal of Biological Chemistry. 288: 36703-16. PMID 24187130 DOI: 10.1074/Jbc.M113.504381 |
0.826 |
|
| 2013 |
Quisenberry AJ, Prisinzano T, Baker LE. Combined effects of modafinil and d-amphetamine in male Sprague-Dawley rats trained to discriminate d-amphetamine. Pharmacology, Biochemistry, and Behavior. 110: 208-15. PMID 23880213 DOI: 10.1016/J.Pbb.2013.07.011 |
0.303 |
|
| 2013 |
Vasiljevik T, Franks LN, Ford BM, Douglas JT, Prather PL, Fantegrossi WE, Prisinzano TE. Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse. Journal of Medicinal Chemistry. 56: 4537-50. PMID 23631463 DOI: 10.1021/Jm400268B |
0.646 |
|
| 2013 |
Prisinzano TE. Neoclerodanes as atypical opioid receptor ligands. Journal of Medicinal Chemistry. 56: 3435-43. PMID 23548164 DOI: 10.1021/Jm400388U |
0.524 |
|
| 2013 |
Negri A, Rives ML, Caspers MJ, Prisinzano TE, Javitch JA, Filizola M. Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening. Journal of Chemical Information and Modeling. 53: 521-6. PMID 23461591 DOI: 10.1021/Ci400019T |
0.524 |
|
| 2013 |
Franklin JM, Vasiljevik T, Prisinzano TE, Carrasco GA. Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 68: 46-58. PMID 23174265 DOI: 10.1016/J.Phrs.2012.11.002 |
0.381 |
|
| 2013 |
MacLean KA, Johnson MW, Reissig CJ, Prisinzano TE, Griffiths RR. Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects. Psychopharmacology. 226: 381-92. PMID 23135605 DOI: 10.1007/S00213-012-2912-9 |
0.329 |
|
| 2013 |
Franklin JM, Vasiljevik T, Prisinzano TE, Carrasco GA. Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 760-7. PMID 22841827 DOI: 10.1016/J.Euroneuro.2012.06.012 |
0.372 |
|
| 2012 |
Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. Acs Chemical Neuroscience. 3: 221-236. PMID 22737280 DOI: 10.1021/Cn200128X |
0.7 |
|
| 2012 |
Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, Kopajtic T, Shi L, Katz JL, Tanda G, Newman AH. R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biological Psychiatry. 72: 405-13. PMID 22537794 DOI: 10.1016/J.Biopsych.2012.03.022 |
0.499 |
|
| 2012 |
Lovell KM, Vasiljevik T, Araya JJ, Lozama A, Prevatt-Smith KM, Day VW, Dersch CM, Rothman RB, Butelman ER, Kreek MJ, Prisinzano TE. Semisynthetic neoclerodanes as kappa opioid receptor probes. Bioorganic & Medicinal Chemistry. 20: 3100-10. PMID 22464684 DOI: 10.1016/J.Bmc.2012.02.040 |
0.812 |
|
| 2012 |
Butelman ER, Caspers M, Lovell KM, Kreek MJ, Prisinzano TE. Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo. The Journal of Pharmacology and Experimental Therapeutics. 341: 802-8. PMID 22434677 DOI: 10.1124/Jpet.112.193227 |
0.747 |
|
| 2012 |
Morani AS, Schenk S, Prisinzano TE, Kivell BM. A single injection of a novel κ opioid receptor agonist salvinorin A attenuates the expression of cocaine-induced behavioral sensitization in rats. Behavioural Pharmacology. 23: 162-70. PMID 22293826 DOI: 10.1097/Fbp.0B013E3283512C1E |
0.391 |
|
| 2012 |
Brents LK, Gallus-Zawada A, Radominska-Pandya A, Vasiljevik T, Prisinzano TE, Fantegrossi WE, Moran JH, Prather PL. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity Biochemical Pharmacology. 83: 952-961. PMID 22266354 DOI: 10.1016/J.Bcp.2012.01.004 |
0.626 |
|
| 2012 |
Lamb K, Tidgewell K, Simpson DS, Bohn LM, Prisinzano TE. Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: new concepts in mu opioid receptor pharmacology: from a symposium on new concepts in mu-opioid pharmacology. Drug and Alcohol Dependence. 121: 181-8. PMID 22119134 DOI: 10.1016/J.Drugalcdep.2011.10.026 |
0.825 |
|
| 2012 |
Holtz NA, Lozama A, Prisinzano TE, Carroll ME. Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone. Drug and Alcohol Dependence. 120: 233-7. PMID 21820819 DOI: 10.1016/J.Drugalcdep.2011.07.010 |
0.751 |
|
| 2011 |
Prevatt-Smith KM, Lovell KM, Simpson DS, Day VW, Douglas JT, Bosch P, Dersch CM, Rothman RB, Kivell B, Prisinzano TE. Potential Drug Abuse Therapeutics Derived from the Hallucinogenic Natural Product Salvinorin A. Medchemcomm. 2: 1217-1222. PMID 22442751 DOI: 10.1039/C1Md00192B |
0.829 |
|
| 2011 |
Lovell KM, Prevatt-Smith KM, Lozama A, Prisinzano TE. Synthesis of neoclerodane diterpenes and their pharmacological effects. Topics in Current Chemistry. 299: 141-85. PMID 21630517 DOI: 10.1007/128_2010_82 |
0.801 |
|
| 2011 |
Cunningham CW, Rothman RB, Prisinzano TE. Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A. Pharmacological Reviews. 63: 316-47. PMID 21444610 DOI: 10.1124/Pr.110.003244 |
0.719 |
|
| 2011 |
Lozama A, Cunningham CW, Caspers MJ, Douglas JT, Dersch CM, Rothman RB, Prisinzano TE. Opioid receptor probes derived from cycloaddition of the hallucinogen natural product salvinorin A. Journal of Natural Products. 74: 718-26. PMID 21338114 DOI: 10.1021/Np1007872 |
0.842 |
|
| 2011 |
Johnson MW, MacLean KA, Reissig CJ, Prisinzano TE, Griffiths RR. Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum. Drug and Alcohol Dependence. 115: 150-5. PMID 21131142 DOI: 10.1016/J.Drugalcdep.2010.11.005 |
0.328 |
|
| 2010 |
Cao J, Prisinzano TE, Okunola OM, Kopajtic T, Shook M, Katz JL, Newman AH. Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues. Acs Medicinal Chemistry Letters. 2: 48-52. PMID 21344069 DOI: 10.1021/Ml1002025 |
0.543 |
|
| 2010 |
Newman JL, Negus SS, Lozama A, Prisinzano TE, Mello NK. Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys. Experimental and Clinical Psychopharmacology. 18: 395-408. PMID 20939643 DOI: 10.1037/A0021042 |
0.769 |
|
| 2010 |
Drinkwater N, Vu H, Lovell KM, Criscione KR, Collins BM, Prisinzano TE, Poulsen SA, McLeish MJ, Grunewald GL, Martin JL. Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. The Biochemical Journal. 431: 51-61. PMID 20642456 DOI: 10.1042/Bj20100651 |
0.728 |
|
| 2010 |
Cunningham CW, Mukhopadhyay A, Lushington GH, Blagg BS, Prisinzano TE, Krise JP. Uptake, distribution and diffusivity of reactive fluorophores in cells: implications toward target identification. Molecular Pharmaceutics. 7: 1301-10. PMID 20557111 DOI: 10.1021/Mp100089K |
0.559 |
|
| 2010 |
Kivell B, Prisinzano TE. Kappa opioids and the modulation of pain. Psychopharmacology. 210: 109-19. PMID 20372880 DOI: 10.1007/S00213-010-1819-6 |
0.405 |
|
| 2010 |
Butelman ER, Rus S, Prisinzano TE, Kreek MJ. The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology. 210: 253-62. PMID 20084367 DOI: 10.1007/S00213-009-1771-5 |
0.519 |
|
| 2010 |
Prevatt-Smith KM, Prisinzano TE. New therapeutic potential for psychoactive natural products. Natural Product Reports. 27: 23-31. PMID 20024092 DOI: 10.1039/B912196J |
0.764 |
|
| 2010 |
Sally EJ, Xu H, Dersch CM, Hsin LW, Chang LT, Prisinzano TE, Simpson DS, Giuvelis D, Rice KC, Jacobson AE, Cheng K, Bilsky EJ, Rothman RB. Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor. Synapse (New York, N.Y.). 64: 280-8. PMID 19953652 DOI: 10.1002/Syn.20723 |
0.629 |
|
| 2010 |
Prisinzano TE. Opiate Receptors and Antagonists: From Bench to Clinic Opiate Receptors and Antagonists: From Bench to Clinic . Edited by Reginald Dean , Edward J. Blisky , and S. Stevens Negus . Humana Press , New York . 2009 . xxxii + 757 pp. 16 × 23.5 cm. ISBN 978-1-58829-881-2 . $149.00. Journal of Medicinal Chemistry. 53: 920-920. DOI: 10.1021/Jm901655C |
0.394 |
|
| 2009 |
Fontana G, Savona G, Rodríguez B, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies on neoclerodane diterpenes from Salvia splendens: oxidative modifications of ring A. Tetrahedron. 65: 1708-1715. PMID 21544261 DOI: 10.1016/J.Tet.2008.12.009 |
0.502 |
|
| 2009 |
Lovell KM, Simpson DS, Cunningham CW, Prisinzano TE. Utilizing nature as a source of new probes for opioid pharmacology. Future Medicinal Chemistry. 1: 285-301. PMID 21425970 DOI: 10.4155/Fmc.09.22 |
0.847 |
|
| 2009 |
Morani AS, Kivell B, Prisinzano TE, Schenk S. Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats. Pharmacology, Biochemistry, and Behavior. 94: 244-9. PMID 19747933 DOI: 10.1016/J.Pbb.2009.09.002 |
0.362 |
|
| 2009 |
Simpson DS, Lovell KM, Lozama A, Han N, Day VW, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: role of the furan in affinity for opioid receptors. Organic & Biomolecular Chemistry. 7: 3748-56. PMID 19707679 DOI: 10.1039/B905148A |
0.845 |
|
| 2009 |
Lozama A, Prisinzano TE. Chemical methods for the synthesis and modification of neoclerodane diterpenes. Bioorganic & Medicinal Chemistry Letters. 19: 5490-5. PMID 19679471 DOI: 10.1016/J.Bmcl.2009.07.069 |
0.767 |
|
| 2009 |
Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, Prisinzano TE, Baumann MH. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. The Journal of Pharmacology and Experimental Therapeutics. 329: 738-46. PMID 19197004 DOI: 10.1124/Jpet.108.146142 |
0.341 |
|
| 2009 |
Prisinzano TE. Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse. Journal of Natural Products. 72: 581-7. PMID 19099466 DOI: 10.1021/Np8005748 |
0.37 |
|
| 2009 |
Butelman ER, Prisinzano TE, Deng H, Rus S, Kreek MJ. Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid. The Journal of Pharmacology and Experimental Therapeutics. 328: 588-97. PMID 19001155 DOI: 10.1124/Jpet.108.145342 |
0.456 |
|
| 2008 |
Fontana G, Savona G, Rodríguez B, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of Opioid Receptor affinity. Tetrahedron. 64: 10041-10048. PMID 20027203 DOI: 10.1016/J.Tet.2008.08.043 |
0.546 |
|
| 2008 |
Xu H, Wang X, Partilla JS, Bishop-Mathis K, Benaderet TS, Dersch CM, Simpson DS, Prisinzano TE, Rothman RB. Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. Brain Research Bulletin. 77: 49-54. PMID 18639745 DOI: 10.1016/J.Brainresbull.2008.05.003 |
0.479 |
|
| 2008 |
Butelman ER, Rus S, Simpson DS, Wolf A, Prisinzano TE, Kreek MJ. The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates. The Journal of Pharmacology and Experimental Therapeutics. 327: 154-60. PMID 18593955 DOI: 10.1124/Jpet.108.140079 |
0.46 |
|
| 2008 |
Prisinzano TE, Rothman RB. Salvinorin A analogs as probes in opioid pharmacology. Chemical Reviews. 108: 1732-43. PMID 18476672 DOI: 10.1021/Cr0782269 |
0.479 |
|
| 2008 |
Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE. Herkinorin analogues with differential beta-arrestin-2 interactions. Journal of Medicinal Chemistry. 51: 2421-31. PMID 18380425 DOI: 10.1021/Jm701162G |
0.834 |
|
| 2008 |
Rothman RB, Baumann MH, Prisinzano TE, Newman AH. Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochemical Pharmacology. 75: 2-16. PMID 17897630 DOI: 10.1016/J.Bcp.2007.08.007 |
0.496 |
|
| 2008 |
Prisinzano TE, Tidgewell K, Harding WW. κ opioids as potential treatments for stimulant dependence Drug Addiction: From Basic Research to Therapy. 231-245. DOI: 10.1007/978-0-387-76678-2_15 |
0.665 |
|
| 2007 |
Holden KG, Tidgewell K, Marquam A, Rothman RB, Navarro H, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position. Bioorganic & Medicinal Chemistry Letters. 17: 6111-5. PMID 17904842 DOI: 10.1016/J.Bmcl.2007.09.050 |
0.762 |
|
| 2007 |
Katavic PL, Lamb K, Navarro H, Prisinzano TE. Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships. Journal of Natural Products. 70: 1278-82. PMID 17685652 DOI: 10.1021/Np070194X |
0.531 |
|
| 2007 |
Simpson DS, Katavic PL, Lozama A, Harding WW, Parrish D, Deschamps JR, Dersch CM, Partilla JS, Rothman RB, Navarro H, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues. Journal of Medicinal Chemistry. 50: 3596-603. PMID 17580847 DOI: 10.1021/Jm070393D |
0.81 |
|
| 2007 |
Xu H, Partilla JS, Wang X, Rutherford JM, Tidgewell K, Prisinzano TE, Bohn LM, Rothman RB. A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence. Synapse (New York, N.Y.). 61: 166-75. PMID 17152090 DOI: 10.1002/Syn.20356 |
0.807 |
|
| 2007 |
Gilbert KM, Boos TL, Dersch CM, Greiner E, Jacobson AE, Lewis D, Matecka D, Prisinzano TE, Zhang Y, Rothman RB, Rice KC, Venanzi CA. DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. Bioorganic & Medicinal Chemistry. 15: 1146-59. PMID 17127069 DOI: 10.1016/J.Bmc.2006.09.070 |
0.449 |
|
| 2007 |
Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Molecular Pharmacology. 71: 549-57. PMID 17090705 DOI: 10.1124/Mol.106.028258 |
0.84 |
|
| 2007 |
Butelman ER, Mandau M, Tidgewell K, Prisinzano TE, Yuferov V, Kreek MJ. Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans. The Journal of Pharmacology and Experimental Therapeutics. 320: 300-6. PMID 17060493 DOI: 10.1124/Jpet.106.112417 |
0.748 |
|
| 2007 |
Rothman RB, Murphy DL, Xu H, Godin JA, Dersch CM, Partilla JS, Tidgewell K, Schmidt M, Prisinzano TE. Salvinorin A: allosteric interactions at the mu-opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 320: 801-10. PMID 17060492 DOI: 10.1124/Jpet.106.113167 |
0.76 |
|
| 2007 |
Bohn LM, Groer CE, Tidgewell K, Moyer R, Harding WW, Prisinzano TE. Mu opioid receptor activation without arrestin‐interactions; a pharmacological approach. The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A426-A |
0.838 |
|
| 2006 |
Tidgewell K, Harding WW, Lozama A, Cobb H, Shah K, Kannan P, Dersch CM, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Synthesis of salvinorin A analogues as opioid receptor probes. Journal of Natural Products. 69: 914-8. PMID 16792410 DOI: 10.1021/Np060094B |
0.842 |
|
| 2006 |
Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring. Bioorganic & Medicinal Chemistry Letters. 16: 3170-4. PMID 16621556 DOI: 10.1016/J.Bmcl.2006.03.062 |
0.798 |
|
| 2006 |
Boos TL, Greiner E, Calhoun WJ, Prisinzano TE, Nightingale B, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter. Bioorganic & Medicinal Chemistry. 14: 3967-73. PMID 16563775 DOI: 10.1016/J.Bmc.2006.01.065 |
0.497 |
|
| 2006 |
Greiner E, Boos TL, Prisinzano TE, De Martino MG, Zeglis B, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity. Journal of Medicinal Chemistry. 49: 1766-72. PMID 16509591 DOI: 10.1021/Jm050766F |
0.464 |
|
| 2006 |
Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Gilmour B, Navarro H, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A. Journal of Natural Products. 69: 107-12. PMID 16441078 DOI: 10.1021/Np050398I |
0.845 |
|
| 2005 |
Harding WW, Hodge M, Wang Z, Woolverton WL, Parrish D, Deschamps JR, Prisinzano TE. Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine. Tetrahedron, Asymmetry. 16: 2249-2256. PMID 16841092 DOI: 10.1016/J.Tetasy.2005.06.012 |
0.603 |
|
| 2005 |
Prisinzano TE, Tidgewell K, Harding WW. Kappa opioids as potential treatments for stimulant dependence. The Aaps Journal. 7: E592-9. PMID 16353938 DOI: 10.1208/Aapsj070361 |
0.806 |
|
| 2005 |
Schmidt MD, Schmidt MS, Butelman ER, Harding WW, Tidgewell K, Murry DJ, Kreek MJ, Prisinzano TE. Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates. Synapse (New York, N.Y.). 58: 208-10. PMID 16138318 DOI: 10.1002/Syn.20191 |
0.772 |
|
| 2005 |
Harding WW, Tidgewell K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE. Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. Journal of Medicinal Chemistry. 48: 4765-71. PMID 16033256 DOI: 10.1021/Jm048963M |
0.845 |
|
| 2005 |
Sulima A, Prisinzano TE, Spande T, Deschamps JR, Whittaker N, Hochberg Z, Jacobson AE, Rice KC. A concise method for the preparation of deuterium-labeled cortisone: synthesis of [6,7-2H]cortisone. Steroids. 70: 763-9. PMID 16005918 DOI: 10.1016/J.Steroids.2005.04.006 |
0.441 |
|
| 2005 |
Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum. Organic Letters. 7: 3017-20. PMID 15987194 DOI: 10.1021/Ol0510522 |
0.763 |
|
| 2005 |
Schmidt MS, Prisinzano TE, Tidgewell K, Harding W, Butelman ER, Kreek MJ, Murry DJ. Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 818: 221-5. PMID 15734162 DOI: 10.1016/J.Jchromb.2004.12.041 |
0.751 |
|
| 2005 |
Deschamps JR, Parrish D, Prisinzano TE. Absolute configuration of the κ-agonist salvinicin A Acta Crystallographica Section a Foundations of Crystallography. 61: c274-c274. DOI: 10.1107/S0108767305088331 |
0.334 |
|
| 2005 |
Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Salvinicins A (I) and B (II), New Neoclerodane Diterpenes from Salvia divinorum. Cheminform. 36. DOI: 10.1002/chin.200547181 |
0.729 |
|
| 2004 |
Tidgewell K, Harding WW, Schmidt M, Holden KG, Murry DJ, Prisinzano TE. A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A. Bioorganic & Medicinal Chemistry Letters. 14: 5099-102. PMID 15380207 DOI: 10.1016/J.Bmcl.2004.07.081 |
0.766 |
|
| 2004 |
Prisinzano T, Dukat M, Law H, Slassi A, MacLean N, DeLannoy I, Glennon RA. 2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT 1D serotonin receptor ligands Bioorganic and Medicinal Chemistry Letters. 14: 4697-4699. PMID 15324890 DOI: 10.1016/J.Bmcl.2004.06.085 |
0.517 |
|
| 2004 |
Prisinzano T, Rice KC, Baumann MH, Rothman RB. Development of Neurochemical Normalization ("Agonist Substitution") Therapeutics for Stimulant Abuse: Focus on the Dopamine Uptake Inhibitor, GBR12909 Current Medicinal Chemistry - Central Nervous System Agents. 4: 47-59. DOI: 10.2174/1568015043477630 |
0.469 |
|
| 2004 |
Prisinzano T, Podobinski J, Tidgewell K, Luo M, Swenson D. Synthesis and determination of the absolute configuration of the enantiomers of modafinil Tetrahedron: Asymmetry. 15: 1053-1058. DOI: 10.1016/J.Tetasy.2004.01.039 |
0.665 |
|
| 2003 |
Rothman RB, Jayanthi S, Wang X, Dersch CM, Cadet JL, Prisinzano T, Rice KC, Baumann MH. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse (New York, N.Y.). 50: 233-9. PMID 14515341 DOI: 10.1002/Syn.10266 |
0.412 |
|
| 2003 |
Greiner E, Prisinzano T, Johnson EM, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. Journal of Medicinal Chemistry. 46: 1465-9. PMID 12672246 DOI: 10.1021/Jm020419V |
0.452 |
|
| 2003 |
Lewis D, Zhang Y, Prisinzano T, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter. Bioorganic & Medicinal Chemistry Letters. 13: 1385-9. PMID 12657288 DOI: 10.1016/S0960-894X(03)00108-2 |
0.458 |
|
| 2003 |
Hsin LW, Prisinzano T, Wilkerson CR, Dersch CM, Horel R, Jacobson AE, Rothman RB, Rice KC. Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. Bioorganic & Medicinal Chemistry Letters. 13: 553-6. PMID 12565970 DOI: 10.1016/S0960-894X(02)00940-X |
0.479 |
|
| 2003 |
Prisinzano T, Hsin L, Folk JE, Flippen-Anderson JL, George C, Jacobson AE, Rice KC. A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl}piperazin-1-yl)-2-phenylpropan-2-ol dimaleate Tetrahedron: Asymmetry. 14: 3285-3289. DOI: 10.1016/J.Tetasy.2003.05.001 |
0.437 |
|
| 2002 |
Prisinzano T, Greiner E, Johnson EM, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter. Journal of Medicinal Chemistry. 45: 4371-4. PMID 12213078 DOI: 10.1021/Jm020264R |
0.443 |
|
| 2002 |
Yu H, Prisinzano T, Dersch CM, Marcus J, Rothman RB, Jacobson AE, Rice KC. Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. Bioorganic & Medicinal Chemistry Letters. 12: 165-8. PMID 11755345 DOI: 10.1016/S0960-894X(01)00689-8 |
0.588 |
|
| 2001 |
Prisinzano T, Law H, Dukat M, Slassi A, MaClean N, Demchyshyn L, Glennon RA. Imidazoline-modified benzylimidazolines as h5-HT(1D/1B) serotonergic ligands. Bioorganic & Medicinal Chemistry. 9: 613-9. PMID 11310595 DOI: 10.1016/S0968-0896(00)00275-3 |
0.459 |
|
| 1998 |
Law H, Dukat M, Teitler M, Lee DKH, Mazzocco L, Kamboj R, Rampersad V, Prisinzano T, Glennon RA. Benzylimidazolines as h5-HT(1B/1D) serotonin receptor ligands: A structure-affinity investigation Journal of Medicinal Chemistry. 41: 2243-2251. PMID 9632357 DOI: 10.1021/Jm970513P |
0.572 |
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