☰

cached image

Leslie A. Kuhn - Publications

Affiliations: 
Michigan State University, East Lansing, MI 
Area:
Biochemistry
Website:
https://bmb.natsci.msu.edu/faculty/leslie-a-kuhn/
Tree Info Similar researchers PubMed Report error

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bemister-Buffington J, Wolf AJ, Raschka S, Kuhn LA. Machine Learning to Identify Flexibility Signatures of Class A GPCR Inhibition. Biomolecules. 10. PMID 32183371 DOI: 10.3390/biom10030454  0.342
2019 Chen J, Kuhn LA. Deciphering the three-domain architecture in schlafens and the structures and roles of human schlafen12 and serpinB12 in transcriptional regulation. Journal of Molecular Graphics & Modelling. 90: 59-76. PMID 31026779 DOI: 10.1016/J.Jmgm.2019.04.003  0.334
2018 Raschka S, More SK, Devadoss D, Zeng B, Kuhn LA, Basson MD. Identification of potential small-molecule protein-protein inhibitors of cancer metastasis by 3D epitope-based computational screening. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society. 69. PMID 29980145 DOI: 10.26402/Jpp.2018.2.11  0.351
2018 Raschka S, Scott AM, Huertas M, Li W, Kuhn LA. Automated Inference of Chemical Discriminants of Biological Activity. Methods in Molecular Biology (Clifton, N.J.). 1762: 307-338. PMID 29594779 DOI: 10.1007/978-1-4939-7756-7_16  0.339
2018 Raschka S, Wolf AJ, Bemister-Buffington J, Kuhn LA. Protein-ligand interfaces are polarized: discovery of a strong trend for intermolecular hydrogen bonds to favor donors on the protein side with implications for predicting and designing ligand complexes. Journal of Computer-Aided Molecular Design. PMID 29435780 DOI: 10.1007/S10822-018-0105-2  0.424
2018 Raschka S, Scott AM, Liu N, Gunturu S, Huertas M, Li W, Kuhn LA. Enabling the hypothesis-driven prioritization of ligand candidates in big databases: Screenlamp and its application to GPCR inhibitor discovery for invasive species control. Journal of Computer-Aided Molecular Design. PMID 29383467 DOI: 10.1007/S10822-018-0100-7  0.339
2016 Raschka S, Bemister-Buffington J, Kuhn LA. Detecting the Native Ligand Orientation by Interfacial Rigidity: SiteInterlock. Proteins. PMID 27699847 DOI: 10.1002/Prot.25172  0.474
2016 Li F, Liu J, Liu N, Kuhn LA, Garavito RM, Ferguson-Miller SM. Translocator protein 18 kDa (TSPO): an old protein with new functions? Biochemistry. PMID 27074410 DOI: 10.1021/Acs.Biochem.6B00142  0.625
2015 Liu N, Van Voorst JR, Johnston JB, Kuhn LA. CholMine: Determinants and Prediction of Cholesterol and Cholate Binding Across Nonhomologous Protein Structures. Journal of Chemical Information and Modeling. 55: 747-59. PMID 25760928 DOI: 10.1021/Ci5006542  0.811
2014 Najt CP, Lwande JS, McIntosh AL, Senthivinayagam S, Gupta S, Kuhn LA, Atshaves BP. Structural and functional assessment of perilipin 2 lipid binding domain(s) Biochemistry. 53: 7051-7066. PMID 25338003 DOI: 10.1021/Bi500918M  0.353
2014 Chaturvedi L, Sun K, Walsh MF, Kuhn LA, Basson MD. The P-loop region of Schlafen 3 acts within the cytosol to induce differentiation of human Caco-2 intestinal epithelial cells. Biochimica Et Biophysica Acta. 1843: 3029-37. PMID 25261706 DOI: 10.1016/J.Bbamcr.2014.09.017  0.302
2014 Roston RL, Wang K, Kuhn LA, Benning C. Structural determinants allowing transferase activity in SENSITIVE TO FREEZING 2, classified as a family I glycosyl hydrolase. The Journal of Biological Chemistry. 289: 26089-106. PMID 25100720 DOI: 10.1074/Jbc.M114.576694  0.319
2014 Ratnayake ND, Liu N, Kuhn LA, Walker KD. Ring-substituted α-arylalanines for probing substituent effects on the isomerization reaction catalyzed by an aminomutase Acs Catalysis. 4: 3077-3090. DOI: 10.1021/Cs500474S  0.315
2013 Buhrow L, Hiser C, Van Voorst JR, Ferguson-Miller S, Kuhn LA. Computational prediction and in vitro analysis of potential physiological ligands of the bile acid binding site in cytochrome c oxidase. Biochemistry. 52: 6995-7006. PMID 24073649 DOI: 10.1021/Bi400674H  0.771
2013 Hiser C, Buhrow L, Liu J, Kuhn L, Ferguson-Miller S. A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase. Biochemistry. 52: 1385-96. PMID 23351100 DOI: 10.1021/Bi3014505  0.795
2013 Buhrow L, Hiser C, Voorst JRV, Ferguson-Miller S, Kuhn LA. Three-Pronged Computational Approach to Predict Regulatory Ligands of Cytochrome C Oxidase Biophysical Journal. 104: 379a. DOI: 10.1016/J.Bpj.2012.11.2113  0.807
2012 Buhrow L, Ferguson-Miller S, Kuhn LA. From static structure to living protein: computational analysis of cytochrome c oxidase main-chain flexibility. Biophysical Journal. 102: 2158-66. PMID 22824280 DOI: 10.1016/J.Bpj.2012.03.040  0.791
2012 Van Voorst JR, Tong Y, Kuhn LA. ArtSurf: A method for deformable partial matching of protein small-molecule binding sites 2012 Acm Conference On Bioinformatics, Computational Biology and Biomedicine, Bcb 2012. 36-43. DOI: 10.1145/2382936.2382941  0.79
2010 Canella D, Gilmour SJ, Kuhn LA, Thomashow MF. DNA binding by the Arabidopsis CBF1 transcription factor requires the PKKP/RAGRxKFxETRHP signature sequence. Biochimica Et Biophysica Acta. 1799: 454-62. PMID 19948259 DOI: 10.1016/J.Bbagrm.2009.11.017  0.382
2009 Zavodszky MI, Rohatgi A, Van Voorst JR, Yan H, Kuhn LA. Scoring ligand similarity in structure-based virtual screening. Journal of Molecular Recognition : Jmr. 22: 280-92. PMID 19235177 DOI: 10.1002/Jmr.942  0.776
2009 Keating KS, Flores SC, Gerstein MB, Kuhn LA. StoneHinge: hinge prediction by network analysis of individual protein structures. Protein Science : a Publication of the Protein Society. 18: 359-71. PMID 19180449 DOI: 10.1002/Pro.38  0.412
2008 Quiroz-Valenzuela S, Sukuru SC, Hausinger RP, Kuhn LA, Heller WT. The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering. Archives of Biochemistry and Biophysics. 480: 51-7. PMID 18823937 DOI: 10.1016/J.Abb.2008.09.004  0.798
2008 Flores SC, Keating KS, Painter J, Morcos F, Nguyen K, Merritt EA, Kuhn LA, Gerstein MB. HingeMaster: normal mode hinge prediction approach and integration of complementary predictors. Proteins. 73: 299-319. PMID 18433058 DOI: 10.1002/Prot.22060  0.355
2008 Kron MA, Cichanowicz S, Hendrick A, Liu A, Leykam J, Kuhn LA. Using structural analysis to generate parasite-selective monoclonal antibodies. Protein Science : a Publication of the Protein Society. 17: 983-9. PMID 18411421 DOI: 10.1110/Ps.073429808  0.359
2006 Müller TA, Zavodszky MI, Feig M, Kuhn LA, Hausinger RP. Structural basis for the enantiospecificities of R- and S-specific phenoxypropionate/alpha-ketoglutarate dioxygenases. Protein Science : a Publication of the Protein Society. 15: 1356-68. PMID 16731970 DOI: 10.1110/Ps.052059406  0.734
2006 Sukuru SC, Crepin T, Milev Y, Marsh LC, Hill JB, Anderson RJ, Morris JC, Rohatgi A, O'Mahony G, Grøtli M, Danel F, Page MG, Härtlein M, Cusack S, Kron MA, ... Kuhn LA, et al. Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change. Journal of Computer-Aided Molecular Design. 20: 159-78. PMID 16645791 DOI: 10.1007/S10822-006-9043-5  0.801
2005 Zavodszky MI, Kuhn LA. Side-chain flexibility in protein-ligand binding: the minimal rotation hypothesis. Protein Science : a Publication of the Protein Society. 14: 1104-14. PMID 15772311 DOI: 10.1110/Ps.041153605  0.749
2005 Thorpe MF, Chubynsky M, Hespenheide B, Menor S, Jacobs DJ, Kuhn LA, Zavodszky MI, Lei M, Rader AJ, Whiteley W. Flexibility in biomolecules Current Topics in Physics: in Honor of Sir Roger J. Elliott. 97-112. DOI: 10.1142/9781860947209_0006  0.771
2004 Zavodszky MI, Lei M, Thorpe MF, Day AR, Kuhn LA. Modeling correlated main-chain motions in proteins for flexible molecular recognition. Proteins. 57: 243-61. PMID 15340912 DOI: 10.1002/Prot.20179  0.76
2004 Gohlke H, Kuhn LA, Case DA. Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach. Proteins. 56: 322-37. PMID 15211515 DOI: 10.1002/Prot.20116  0.408
2004 Lei M, Zavodszky MI, Kuhn LA, Thorpe MF. Sampling protein conformations and pathways. Journal of Computational Chemistry. 25: 1133-48. PMID 15116357 DOI: 10.1002/Jcc.20041  0.756
2003 Hespenheide BM, Kuhn LA. Discovery of a significant, nontopological preference for antiparallel alignment of helices with parallel regions in sheets. Protein Science : a Publication of the Protein Society. 12: 1119-25. PMID 12717033 DOI: 10.1110/Ps.0238803  0.784
2002 Zavodszky MI, Sanschagrin PC, Korde RS, Kuhn LA. Distilling the essential features of a protein surface for improving protein-ligand docking, scoring, and virtual screening. Journal of Computer-Aided Molecular Design. 16: 883-902. PMID 12825621 DOI: 10.1023/A:1023866311551  0.807
2002 Hespenheide BM, Rader AJ, Thorpe MF, Kuhn LA. Identifying protein folding cores from the evolution of flexible regions during unfolding. Journal of Molecular Graphics & Modelling. 21: 195-207. PMID 12463638 DOI: 10.1016/S1093-3263(02)00146-8  0.791
2002 Rader AJ, Hespenheide BM, Kuhn LA, Thorpe MF. Protein unfolding: rigidity lost. Proceedings of the National Academy of Sciences of the United States of America. 99: 3540-5. PMID 11891336 DOI: 10.1073/Pnas.062492699  0.792
2001 Howell EE, Shukla U, Hicks SN, Smiley RD, Kuhn LA, Zavodszky MI. One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme. Journal of Computer-Aided Molecular Design. 15: 1035-52. PMID 11989624 DOI: 10.1023/A:1014824725891  0.752
2001 Jacobs DJ, Rader AJ, Kuhn LA, Thorpe MF. Protein flexibility predictions using graph theory. Proteins. 44: 150-65. PMID 11391777 DOI: 10.1002/Prot.1081  0.725
2001 Thorpe MF, Lei M, Rader AJ, Jacobs DJ, Kuhn LA. Protein flexibility and dynamics using constraint theory. Journal of Molecular Graphics & Modelling. 19: 60-9. PMID 11381531 DOI: 10.1016/S1093-3263(00)00122-4  0.7
2001 Kuhn LA, Thorpe MF. Introduction and foreword to the special issue on protein flexibility and folding Journal of Molecular Graphics and Modelling. 19: 1-2. DOI: 10.1016/S1093-3263(01)00094-8  0.383
2000 Thorpe MF, Hespenheide BM, Yang Y, Kuhn LA. Flexibility and critical hydrogen bonds in cytochrome c. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 191-202. PMID 10902168  0.786
2000 Schnecke V, Kuhn LA. Virtual screening with solvation and ligand-induced complementarity Perspectives in Drug Discovery and Design. 20: 171-190. DOI: 10.1023/A:1008737207775  0.451
2000 Thorpe MF, Kuhn LA. Rigidity in glasses and proteins Periodica Mathematica Hungarica. 39: 241-252. DOI: 10.1023/A:1004867612889  0.345
2000 Zavodszky MI, Sanschagrin PC, Kuhn LA. Induced fit in database screening Journal of Molecular Graphics and Modelling. 18: 558. DOI: 10.1016/S1093-3263(00)80142-4  0.742
2000 Thorpe M, Rader A, Lei M, Kuhn LA, Jacobs D. Predicting flexibility in proteins using constraint theory Journal of Molecular Graphics and Modelling. 18: 556. DOI: 10.1016/S1093-3263(00)80134-5  0.694
2000 Rader A, Kuhn LA, Hespenheide B, Thorpe M. The transition between rigidity and flexibility in proteins and glasses Journal of Molecular Graphics and Modelling. 18: 554-555. DOI: 10.1016/S1093-3263(00)80128-X  0.767
2000 Kuhn LA, Hespenheide B, Rader AJ, Thorpe M. A graph theory approach to predicting unfolding pathways of proteins Journal of Molecular Graphics and Modelling. 18: 553. DOI: 10.1016/S1093-3263(00)80123-0  0.767
2000 Lei M, Kuhn LA, Thorpe MF. Constrained dynamics of the flexible regions in proteins Journal of Molecular Graphics and Modelling. 18: 551. DOI: 10.1016/S1093-3263(00)80116-3  0.353
2000 Krishnamurthy H, Rader AJ, Thorpe MF, Kuhn LA, Gregory Zeikus J, Vieille C. Testing FIRST predictions on protein stability using adenylate kinase as a model enzyme Journal of Molecular Graphics and Modelling. 18: 551. DOI: 10.1016/S1093-3263(00)80115-1  0.688
2000 Hespenheide BM, Thorpe MF, Kuhn LA. Protein flexibility and unfolding pathways Journal of Molecular Graphics and Modelling. 18: 550. DOI: 10.1016/S1093-3263(00)80113-8  0.788
1999 Schnecke V, Kuhn LA. Database screening for HIV protease ligands: the influence of binding-site conformation and representation on ligand selectivity Proceedings / ... International Conference On Intelligent Systems For Molecular Biology ; Ismb. International Conference On Intelligent Systems For Molecular Biology. 242-251. PMID 10786307  0.318
1999 Essigmann B, Hespenheide BM, Kuhn LA, Benning C. Prediction of the active-site structure and NAD(+) binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis. Archives of Biochemistry and Biophysics. 369: 30-41. PMID 10462438 DOI: 10.1006/Abbi.1999.1344  0.796
1999 Fan L, Sanschagrin PC, Kaguni LS, Kuhn LA. The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: implications for a dual role as a primer recognition factor and processivity clamp. Proceedings of the National Academy of Sciences of the United States of America. 96: 9527-32. PMID 10449726 DOI: 10.1073/Pnas.96.17.9527  0.748
1999 Yuan Q, Pestka JJ, Hespenheide BM, Kuhn LA, Linz JE, Hart LP. Identification of mimotope peptides which bind to the mycotoxin deoxynivalenol-specific monoclonal antibody. Applied and Environmental Microbiology. 65: 3279-86. PMID 10427007 DOI: 10.1128/Aem.65.8.3279-3286.1999  0.765
1998 Sanschagrin PC, Kuhn LA. Cluster analysis of consensus water sites in thrombin and trypsin shows conservation between serine proteases and contributions to ligand specificity. Protein Science : a Publication of the Protein Society. 7: 2054-64. PMID 9792092 DOI: 10.1002/Pro.5560071002  0.764
1998 Schnecke V, Swanson CA, Getzoff ED, Tainer JA, Kuhn LA. Screening a peptidyl database for potential ligands to proteins with side-chain flexibility. Proteins. 33: 74-87. PMID 9741846 DOI: 10.1002/(Sici)1097-0134(19981001)33:1<74::Aid-Prot7>3.0.Co;2-L  0.495
1998 Craig L, Sanschagrin PC, Rozek A, Lackie S, Kuhn LA, Scott JK. The role of structure in antibody cross-reactivity between peptides and folded proteins. Journal of Molecular Biology. 281: 183-201. PMID 9680484 DOI: 10.1006/Jmbi.1998.1907  0.763
1997 Raymer ML, Sanschagrin PC, Punch WF, Venkataraman S, Goodman ED, Kuhn LA. Predicting conserved water-mediated and polar ligand interactions in proteins using a K-nearest-neighbors genetic algorithm. Journal of Molecular Biology. 265: 445-64. PMID 9034363 DOI: 10.1006/Jmbi.1996.0746  0.786
1996 Kuhn LA, Raymer ML, Punch WF, Sanschagrin PC, Goodman ED. Predicting and analyzing determinants of water-mediated ligand recognition Acta Crystallographica Section a Foundations of Crystallography. 52: C87-C87. DOI: 10.1107/S0108767396095621  0.755
1995 Kuhn LA, Swanson CA, Pique ME, Tainer JA, Getzoff ED. Atomic and residue hydrophilicity in the context of folded protein structures. Proteins. 23: 536-47. PMID 8749849 DOI: 10.1002/Prot.340230408  0.373
1995 Pond L, Kuhn LA, Teyton L, Schutze MP, Tainer JA, Jackson MR, Peterson PA. A role for acidic residues in Di-leucine motif-based targeting to the endocytic pathway Journal of Biological Chemistry. 270: 19989-19997. PMID 7650016 DOI: 10.1074/Jbc.270.34.19989  0.361
1993 Kuhn LA, Swanson CA, Siani MA, Tainer JA, Getzoff ED. Amino acid hydrophobicity in the context of folded proteins: A crystallographic hydration scale Protein Engineering, Design and Selection. 6: 129. DOI: 10.1093/Protein/6.Supplement.129-A  0.349
1992 Kuhn LA, Siani MA, Pique ME, Fisher CL, Getzoff ED, Tainer JA. The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures Journal of Molecular Biology. 228: 13-22. PMID 1447777 DOI: 10.1016/0022-2836(92)90487-5  0.377
1991 Collawn JF, Kuhn LA, Sue Liu LF, Tainer JA, Trowbridge IS. Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor Embo Journal. 10: 3247-3253. PMID 1655415 DOI: 10.1002/J.1460-2075.1991.Tb04888.X  0.302
1990 Collawn JF, Stangel M, Kuhn LA, Esekogwu V, Jing S, Trowbridge IS, Tainer JA. Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis Cell. 63: 1061-1072. PMID 2257624 DOI: 10.1016/0092-8674(90)90509-D  0.356
1990 Kuhn LA, Griffin JH, Fisher CL, Greengard JS, Bouma BN, España F, Tainer JA. Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor Proceedings of the National Academy of Sciences of the United States of America. 87: 8506-8510. PMID 2172989 DOI: 10.1073/Pnas.87.21.8506  0.43
1985 Kuhn LA, Leigh JS. A statistical technique for predicting membrane protein structure. Biochimica Et Biophysica Acta. 828: 351-61. PMID 3986213 DOI: 10.1016/0167-4838(85)90316-4  0.57
1985 Frey TG, Kuhn LA, Leigh JS, Costello MJ, Chan SH. Cytochrome oxidase: structural insights from electron microscopy and from secondary structure prediction. Journal of Inorganic Biochemistry. 23: 155-62. PMID 2991452 DOI: 10.1016/0162-0134(85)85020-0  0.464
Show low-probability matches.