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Jer-Yen Yang, Ph.D. - Publications

Affiliations: 
2009 The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Oncology, Molecular Biology
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhang Y, Wu MJ, Lu WC, Li YC, Chang CJ, Yang JY. Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer. Cell Metabolism. 36: 193-208.e8. PMID 38171333 DOI: 10.1016/j.cmet.2023.12.003  0.719
2023 Gumilar KE, Chin Y, Ibrahim IH, Tjokroprawiro BA, Yang JY, Zhou M, Gassman NR, Tan M. Heat Shock Factor 1 Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology. Cancers. 15. PMID 37958341 DOI: 10.3390/cancers15215167  0.719
2022 Gu X, He M, Lebedev T, Lin CH, Hua ZY, Zheng YG, Li ZJ, Yang JY, Li XG. PRMT1 is an important factor for medulloblastoma cell proliferation and survival. Biochemistry and Biophysics Reports. 32: 101364. PMID 36237442 DOI: 10.1016/j.bbrep.2022.101364  0.695
2021 Gampala S, Yang JY. Hedgehog Pathway Inhibitors against Tumor Microenvironment. Cells. 10. PMID 34831357 DOI: 10.3390/cells10113135  0.718
2021 Gampala S, Zhang G, Chang CJ, Yang JY. Activation of AMPK sensitizes medulloblastoma to Vismodegib and overcomes Vismodegib-resistance. Faseb Bioadvances. 3: 459-469. PMID 34124601 DOI: 10.1096/fba.2020-00032  0.696
2020 Kim MR, Wu MJ, Zhang Y, Yang JY, Chang CJ. TET2 directs mammary luminal cell differentiation and endocrine response. Nature Communications. 11: 4642. PMID 32934200 DOI: 10.1038/s41467-020-18129-w  0.729
2019 Wu M, Kim MR, Gampala S, Zhang Y, Wang Y, Yang J, Chang C. Abstract 798: Epithelial-mesenchymal transition directs stem cell polarity via regulation of mitofusin Cancer Research. 79: 798-798. DOI: 10.1158/1538-7445.Am2019-798  0.719
2018 Wu MJ, Chen YS, Kim MR, Chang CC, Gampala S, Zhang Y, Wang Y, Chang CY, Yang JY, Chang CJ. Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin. Cell Metabolism. PMID 30527740 DOI: 10.1016/j.cmet.2018.11.004  0.684
2018 Kumari R, Silic MR, Jones-Hall YL, Nin-Velez A, Yang JY, Mittal SK, Zhang G. Identification of as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget. 9: 23494-23504. PMID 29805750 DOI: 10.18632/Oncotarget.25236  0.699
2017 Zhang R, Huang SY, Li KK, Li YH, Hsu WH, Zhang GJ, Chang CJ, Yang JY. Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation. Oncotarget. PMID 28562331 DOI: 10.18632/oncotarget.17769  0.675
2017 Weng S, Yang JY, Li YH, Blatchley ER. UV-induced effects on toxicity of model disinfection byproducts. The Science of the Total Environment. 599: 94-97. PMID 28467913 DOI: 10.1016/J.Scitotenv.2017.04.198  0.628
2017 Cui Z, Shen Y, Chen KH, Mittal SK, Yang JY, Zhang G. Corrigendum: KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors. Scientific Reports. 7: 46392. PMID 28436992 DOI: 10.1038/Srep46392  0.69
2017 Cui Z, Shen Y, Chen KH, Mittal SK, Yang JY, Zhang G. KANK1 inhibits cell growth by inducing apoptosis though regulating CXXC5 in human malignant peripheral nerve sheath tumors. Scientific Reports. 7: 40325. PMID 28067315 DOI: 10.1038/Srep40325  0.746
2016 Hensley MR, Chua RF, Leung YF, Yang JY, Zhang G. Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. Plos One. 11: e0163229. PMID 27658201 DOI: 10.1371/Journal.Pone.0163229  0.693
2016 Zhang X, Li J, Yang JY, Wood KV, Rothwell AP, Li W, Blatchley ER. Chlorine/UV Process for Decomposition and Detoxification of Microcystin-LR. Environmental Science & Technology. PMID 27338715 DOI: 10.1021/acs.est.6b02009  0.605
2016 Hensley MR, Cui Z, Chua RF, Simpson S, Shammas NL, Yang JY, Leung YF, Zhang G. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Scientific Reports. 6: 27816. PMID 27292017 DOI: 10.1038/Srep27816  0.612
2015 Huang SY, Yang JY. Targeting the Hedgehog Pathway in Pediatric Medulloblastoma. Cancers. 7: 2110-23. PMID 26512695 DOI: 10.3390/Cancers7040880  0.729
2015 Li YH, Luo J, Mosley YC, Hedrick VE, Paul LN, Chang J, Zhang G, Wang YK, Banko MR, Brunet A, Kuang S, Wu JL, Chang CJ, Scott MP, Yang JY. AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Reports. PMID 26190112 DOI: 10.1016/J.Celrep.2015.06.054  0.721
2015 Chang CC, Wu MJ, Yang JY, Camarillo IG, Chang CJ. Leptin-STAT3-G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression. Cancer Research. 75: 2375-86. PMID 25840984 DOI: 10.1158/0008-5472.Can-14-3076  0.727
2015 Zhang G, Yang JY, Cui Z. New insight into cancer aneuploidy in zebrafish. International Review of Cell and Molecular Biology. 314: 149-70. PMID 25619717 DOI: 10.1016/Bs.Ircmb.2014.09.001  0.686
2014 Wu PC, Lu JW, Yang JY, Lin IH, Ou DL, Lin YH, Chou KH, Huang WF, Wang WP, Huang YL, Hsu C, Lin LI, Lin YM, Shen CK, Tzeng TY. H3K9 histone methyltransferase, KMT1E/SETDB1, cooperates with the SMAD2/3 pathway to suppress lung cancer metastasis. Cancer Research. 74: 7333-43. PMID 25477335 DOI: 10.1158/0008-5472.Can-13-3572  0.738
2014 Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. The Journal of Clinical Investigation. 124: 3093-106. PMID 24911147 DOI: 10.1172/JCI73351  0.745
2013 Zhang G, Vemulapalli TH, Yang JY. Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution. Applied & Translational Genomics. 2: 48-54. PMID 27896055 DOI: 10.1016/J.Atg.2013.06.002  0.682
2011 Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, et al. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. The Journal of Clinical Investigation. 121: 4526-36. PMID 21985787 DOI: 10.1172/Jci45008  0.767
2011 Yang JY, Hung MC. Deciphering the role of forkhead transcription factors in cancer therapy. Current Drug Targets. 12: 1284-90. PMID 21443462  0.78
2011 Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nature Cell Biology. 13: 317-23. PMID 21336307 DOI: 10.1038/Ncb2173  0.77
2011 Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. Cancer Cell. 19: 86-100. PMID 21215703 DOI: 10.1016/J.Ccr.2010.10.035  0.781
2011 Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nature Cell Biology. 13: 87-94. PMID 21131960 DOI: 10.1038/ncb2139  0.81
2011 Yang J, Lee EY, Scott MP. Abstract 932: Mechanisms of hedgehog target gene selection in development and cancer Cancer Research. 71: 932-932. DOI: 10.1158/1538-7445.Am2011-932  0.722
2011 Chao C, Chang C, Xia W, Yang J, Xiong Y, Li C, Hung M. Abstract 4710: p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through modulation of miRNAs Cancer Research. 71: 4710-4710. DOI: 10.1158/1538-7445.Am2011-4710  0.758
2011 Chang C, Chao C, Xia W, Yang J, Xiong Y, Li C, Yu W, Rehman SK, Hsu JL, Lee H, Liu M, Chen C, Yu D, Hung M. p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs Nature Cell Biology. 13: 1467-1467. DOI: 10.1038/ncb2402  0.64
2010 Cheng X, Xia W, Yang JY, Hsu JL, Chou CK, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochemical and Biophysical Research Communications. 403: 103-7. PMID 21040707 DOI: 10.1016/J.Bbrc.2010.10.126  0.799
2010 Cheng X, Xia W, Yang JY, Hsu JL, Lang JY, Chou CK, Du Y, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Research. 70: 7684-9. PMID 20841468 DOI: 10.1158/0008-5472.Can-09-3231  0.809
2010 Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Research. 70: 4709-18. PMID 20484037 DOI: 10.1158/0008-5472.Can-09-4524  0.769
2010 Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Research. 70: 2424-34. PMID 20215498 DOI: 10.1158/0008-5472.Can-09-0878  0.751
2010 Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, et al. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Science Signaling. 3: ra9. PMID 20145209 DOI: 10.1126/Scisignal.2000590  0.806
2009 Liao Y, Wei Y, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK, Sarbassov D, Shi D, Yu D, Hung MC. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 28: 2436-45. PMID 19448664 DOI: 10.1038/Onc.2009.98  0.69
2009 Yang JY, Hung MC. A new fork for clinical application: targeting forkhead transcription factors in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 752-7. PMID 19188143 DOI: 10.1158/1078-0432.CCR-08-0124  0.778
2008 Ding Q, Huo L, Yang JY, Xia W, Wei Y, Liao Y, Chang CJ, Yang Y, Lai CC, Lee DF, Yen CJ, Chen YJ, Hsu JM, Kuo HP, Lin CY, et al. Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Research. 68: 6109-17. PMID 18676833 DOI: 10.1158/0008-5472.CAN-08-0579  0.819
2008 Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nature Cell Biology. 10: 138-48. PMID 18204439 DOI: 10.1038/Ncb1676  0.784
2007 Tsai KL, Sun YJ, Huang CY, Yang JY, Hung MC, Hsiao CD. Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Research. 35: 6984-94. PMID 17940099 DOI: 10.1093/nar/gkm703  0.71
2007 Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, Yang JY, et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 130: 440-55. PMID 17693255 DOI: 10.1016/j.cell.2007.05.058  0.805
2007 Ding Q, He X, Xia W, Hsu JM, Chen CT, Li LY, Lee DF, Yang JY, Xie X, Liu JC, Hung MC. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Research. 67: 4564-71. PMID 17495324 DOI: 10.1158/0008-5472.CAN-06-1788  0.808
2006 Yang JY, Zong CS, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation Molecular and Cellular Biology. 26: 7269-7282. PMID 16980628 DOI: 10.1128/MCB.00172-06  0.743
2006 Yang JY, Xia W, Hu MC. Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. International Journal of Oncology. 29: 643-8. PMID 16865280  0.677
2005 Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, et al. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Molecular Cell. 19: 159-70. PMID 16039586 DOI: 10.1016/j.molcel.2005.06.009  0.77
2004 Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Research. 64: 9080-5. PMID 15604276 DOI: 10.1158/0008-5472.Can-04-2419  0.78
2004 Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 117: 225-37. PMID 15084260 DOI: 10.1016/S0092-8674(04)00302-2  0.834
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