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H.C Chan - Publications

Affiliations: 
The Chinese University of Hong Kong, Hong Kong, Hong Kong 
Area:
Oncology, Cell Biology, General Biology
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Year Citation  Score
2022 Li X, Yuan C, Shi J, Kang H, Chen Y, Duan Y, Jin J, Cheung LP, Li TC, Liu Y, Cui Y, Ruan YC, Jiang X, Cai Z, Chan HC, et al. β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility. Cell Reports. Medicine. 100825. PMID 36513070 DOI: 10.1016/j.xcrm.2022.100825  0.646
2019 Wong TW, Kan CD, Chiu WT, Fok KL, Ruan YC, Jiang X, Chen J, Kao CC, Chen IY, Lin HC, Chou CH, Lin CW, Yu CK, Tsao S, Lee YP, ... Chan HC, et al. Progenitor Cells Derived from Drain Waste Product of Open-Heart Surgery in Children. Journal of Clinical Medicine. 8. PMID 31336927 DOI: 10.3390/Jcm8071028  0.615
2018 Wang C, Zhang J, Fok KL, Tsang LL, Ye M, Liu J, Li F, Zhao AZ, Chan HC, Chen H. CD147 induces epithelial-to-mesenchymal transition by disassembling CAS/E-cadherin/β-catenin complex in human endometriosis. The American Journal of Pathology. PMID 29630856 DOI: 10.1016/J.Ajpath.2018.03.004  0.626
2018 Li X, Fok KL, Guo J, Wang Y, Liu Z, Chen Z, Wang C, Ruan YC, Yu SS, Zhao H, Wu J, Jiang X, Chan HC. Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR. Biochimica Et Biophysica Acta. PMID 29326073 DOI: 10.1016/J.Bbamcr.2018.01.005  0.632
2017 Diao R, Wang T, Fok KL, Li X, Ruan Y, Yu MK, Cheng Y, Chen Y, Chen H, Mou L, Cai X, Wang Y, Cai Z, Zeng X, Chan HC. CCR6 is required for ligand-induced CatSper activation in human sperm. Oncotarget. 8: 91445-91458. PMID 29207656 DOI: 10.18632/Oncotarget.20651  0.643
2017 Fok KL, Bose R, Sheng K, Chang CW, Katz-Egorov M, Culty M, Su S, Yang M, Ruan YC, Chan HC, Iavarone A, Lasorella A, Cencic R, Pelletier J, Nagano M, et al. Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Endocrinology. PMID 28938460 DOI: 10.1210/En.2017-00396  0.645
2016 Wang C, Fok KL, Cai Z, Chen H, Chan HC. CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways. Oncotarget. PMID 27902973 DOI: 10.18632/Oncotarget.13624  0.635
2016 Lu YC, Yang J, Fok KL, Ye YH, Jin L, Chen ZY, Zhang XM, Huang HF, Chan HC. Involvement of Cl(-)/HCO3(-) exchanger SLC26A3 and SLC26A6 in preimplantation embryo cleavage. Scientific Reports. 6: 28402. PMID 27346053 DOI: 10.1038/Srep28402  0.648
2015 Chang KC, Lee AS, Chen WY, Lin YN, Hsu JF, Chan HC, Chang CM, Chang SS, Pan CC, Sawamura T, Chang CT, Su MJ, Chen CH. Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction. Journal of Molecular and Cellular Cardiology. 84: 36-44. PMID 25871829 DOI: 10.1016/j.yjmcc.2015.03.016  0.435
2014 Diao R, Fok KL, Chen H, Yu MK, Duan Y, Chung CM, Li Z, Wu H, Li Z, Zhang H, Ji Z, Zhen W, Ng CF, Gui Y, Cai Z, ... Chan HC, et al. Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. Science Translational Medicine. 6: 249ra108. PMID 25122636 DOI: 10.1126/Scitranslmed.3009071  0.646
2014 Guo JH, Chen H, Ruan YC, Zhang XL, Zhang XH, Fok KL, Tsang LL, Yu MK, Huang WQ, Sun X, Chung YW, Jiang X, Sohma Y, Chan HC. Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature Communications. 5: 4420. PMID 25025956 DOI: 10.1038/Ncomms5420  0.624
2014 Lee AS, Chen WY, Chan HC, Hsu JF, Shen MY, Chang CM, Bair H, Su MJ, Chang KC, Chen CH. Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL. Cardiovascular Diabetology. 13: 64. PMID 24666525 DOI: 10.1186/1475-2840-13-64  0.444
2014 Fok KL, Chen H, Ruan YC, Chan HC. Novel regulators of spermatogenesis. Seminars in Cell & Developmental Biology. 29: 31-42. PMID 24594193 DOI: 10.1016/J.Semcdb.2014.02.008  0.634
2013 Diao R, Fok KL, Zhao L, Chen H, Tang H, Chen J, Zheng A, Zhang X, Gui Y, Chan HC, Cai Z. Decreased expression of cystic fibrosis transmembrane conductance regulator impairs sperm quality in aged men. Reproduction (Cambridge, England). 146: 637-45. PMID 24077955 DOI: 10.1530/REP-13-0146  0.637
2013 Zhang JT, Jiang XH, Xie C, Cheng H, Da Dong J, Wang Y, Fok KL, Zhang XH, Sun TT, Tsang LL, Chen H, Sun XJ, Chung YW, Cai ZM, Jiang WG, ... Chan HC, et al. Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer. Biochimica Et Biophysica Acta. 1833: 2961-9. PMID 23916755 DOI: 10.1016/J.Bbamcr.2013.07.021  0.644
2013 Xie C, Jiang XH, Zhang JT, Sun TT, Dong JD, Sanders AJ, Diao RY, Wang Y, Fok KL, Tsang LL, Yu MK, Zhang XH, Chung YW, Ye L, Zhao MY, ... ... Chan HC, et al. CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. Oncogene. 32: 2282-91, 2291.e1-7. PMID 22797075 DOI: 10.1038/Onc.2012.251  0.627
2012 Zhang XH, Ma ZG, Rowlands DK, Gou YL, Fok KL, Wong HY, Yu MK, Tsang LL, Mu L, Chen L, Yung WH, Chung YW, Zhang BL, Zhao H, Chan HC. Flavonoid Myricetin Modulates GABA(A) Receptor Activity through Activation of Ca(2+) Channels and CaMK-II Pathway. Evidence-Based Complementary and Alternative Medicine : Ecam. 2012: 758097. PMID 23258999 DOI: 10.1155/2012/758097  0.622
2012 Chen J, Fok KL, Chen H, Zhang XH, Xu WM, Chan HC. Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2. Human Reproduction (Oxford, England). 27: 2585-97. PMID 22777528 DOI: 10.1093/Humrep/Des254  0.639
2012 Ruan YC, Guo JH, Liu X, Zhang R, Tsang LL, Dong JD, Chen H, Yu MK, Jiang X, Zhang XH, Fok KL, Chung YW, Huang H, Zhou WL, Chan HC. Activation of the epithelial Na+ channel triggers prostaglandin Eâ‚‚ release and production required for embryo implantation. Nature Medicine. 18: 1112-7. PMID 22729284 DOI: 10.1038/Nm.2771  0.625
2012 Lu YC, Chen H, Fok KL, Tsang LL, Yu MK, Zhang XH, Chen J, Jiang X, Chung YW, Ma AC, Leung AY, Huang HF, Chan HC. CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development. Cell Research. 22: 1453-66. PMID 22664907 DOI: 10.1038/Cr.2012.88  0.62
2012 Wu W, Song W, Li S, Ouyang S, Fok KL, Diao R, Miao S, Chan HC, Wang L. Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability. Journal of Cell Science. 125: 4219-29. PMID 22641691 DOI: 10.1242/Jcs.086553  0.633
2012 Tang XX, Fok KL, Chen H, Chan KS, Tsang LL, Rowlands DK, Zhang XH, Dong JD, Ruan YC, Jiang X, Yu SS, Chung YW, Chan HC. Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing. Journal of Cellular Physiology. 227: 3887-94. PMID 22552906 DOI: 10.1002/Jcp.24101  0.659
2012 Chen H, Fok KL, Jiang X, Jiang J, Chen Z, Gui Y, Chan HC, Cai Z. CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia. Human Reproduction (Oxford, England). 27: 1568-76. PMID 22451502 DOI: 10.1093/Humrep/Des050  0.631
2012 Fu J, Wang Y, Fok KL, Yang D, Qiu Y, Chan HC, Koide SS, Miao S, Wang L. Anti-ACTL7a antibodies: a cause of infertility. Fertility and Sterility. 97: 1226-33.e1-8. PMID 22386842 DOI: 10.1016/J.Fertnstert.2012.02.023  0.586
2012 Chen H, Guo JH, Lu YC, Ding GL, Yu MK, Tsang LL, Fok KL, Liu XM, Zhang XH, Chung YW, Huang P, Huang H, Chan HC. Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS. The Journal of Clinical Endocrinology and Metabolism. 97: 923-32. PMID 22170719 DOI: 10.1210/Jc.2011-1363  0.635
2011 Liu Y, Jiang X, Zhang X, Chen R, Sun T, Fok KL, Dong J, Tsang LL, Yi S, Ruan Y, Guo J, Yu MK, Tian Y, Chung YW, Yang M, ... ... Chan HC, et al. Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential. Stem Cells (Dayton, Ohio). 29: 2077-89. PMID 22052697 DOI: 10.1002/Stem.764  0.619
2011 Xu WM, Chen J, Chen H, Diao RY, Fok KL, Dong JD, Sun TT, Chen WY, Yu MK, Zhang XH, Tsang LL, Lau A, Shi QX, Shi QH, Huang PB, ... Chan HC, et al. Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia. Plos One. 6: e19120. PMID 21625623 DOI: 10.1371/Journal.Pone.0019120  0.725
2011 Chen H, Fok KL, Yu S, Jiang J, Chen Z, Gui Y, Cai Z, Chan HC. CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Molecular Human Reproduction. 17: 405-14. PMID 21343160 DOI: 10.1093/Molehr/Gar013  0.624
2010 Ajonuma LC, Fok KL, Ho LS, Chan PK, Chow PH, Tsang LL, Wong CH, Chen J, Li S, Rowlands DK, Chung YW, Chan HC. CFTR is required for cellular entry and internalization of Chlamydia trachomatis. Cell Biology International. 34: 593-600. PMID 20178459 DOI: 10.1042/Cbi20090227  0.654
2010 Xu W, Zhang X, Chen W, Fok KL, Rowlands DK, Chui YL, Chan HC. Immunization with Bin1b decreases sperm motility with compromised fertility in rats. Fertility and Sterility. 93: 952-958.e1. PMID 19135192 DOI: 10.1016/J.Fertnstert.2008.10.066  0.662
2010 Xu W, Wong HYC, Chen W, Shi Q, Chen H, Yu MK, Chan HC, Tierney ML. GABA-A receptor δ subunit is expressed in sperm and important for progesterone-induced AR reaction Cell Biology International. 34: S13-S13. DOI: 10.1042/Cbi034S013D  0.431
2010 Chen H, Fok KL, Gui Y, Cai Z, Chan HC. Co-localization of CD147 and matrix metalloproteinases and its implication for spermatogenesis during mouse testis development Cell Biology International. 34: S8-S8. DOI: 10.1042/Cbi034S008B  0.607
2009 Jin JY, Chen WY, Zhou CX, Chen ZH, Yu-Ying Y, Ni Y, Chan HC, Shi QX. Activation of GABAA receptor/Cl- channel and capacitation in rat spermatozoa: HCO3- and Cl- are essential. Systems Biology in Reproductive Medicine. 55: 97-108. PMID 19462289 DOI: 10.1080/19396360802626648  0.45
2009 Yin L, Chung CM, Huo R, Liu H, Zhou C, Xu W, Zhu H, Zhang J, Shi Q, Wong HY, Chen J, Lu Y, Bi Y, Zhao C, Du Y, ... ... Chan HC, et al. A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction. Cellular and Molecular Life Sciences : Cmls. 66: 900-8. PMID 19153666 DOI: 10.1007/S00018-009-8482-2  0.69
2009 Yin LL, Chung CM, Chen J, Fok KL, Ng CP, Jia RR, Ren X, Zhou J, Zhang T, Zhao XH, Lin M, Zhu H, Zhang XH, Tsang LL, Bi Y, ... ... Chan HC, et al. A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis. Journal of Cellular and Molecular Medicine. 13: 4034-41. PMID 19017363 DOI: 10.1111/J.1582-4934.2008.00576.X  0.625
2009 Chan HC, Ruan YC, He Q, Chen MH, Chen H, Xu WM, Chen WY, Xie C, Zhang XH, Zhou Z. The cystic fibrosis transmembrane conductance regulator in reproductive health and disease. The Journal of Physiology. 587: 2187-95. PMID 19015188 DOI: 10.1113/jphysiol.2008.164970  0.505
2009 Chen WY, Xu WM, Chen ZH, Ni Y, Yuan YY, Zhou SC, Zhou WW, Tsang LL, Chung YW, Höglund P, Chan HC, Shi QX. Cl- is required for HCO3- entry necessary for sperm capacitation in guinea pig: involvement of a Cl-/HCO3- exchanger (SLC26A3) and CFTR. Biology of Reproduction. 80: 115-23. PMID 18784352 DOI: 10.1095/biolreprod.108.068528  0.502
2008 Ajonuma LC, Chan PK, Ng EH, Fok KL, Wong CH, Tsang LL, Tang XX, Ho LS, Lau MC, Chung CM, He Q, Huang HY, Yang DZ, Rowlands DK, Chung YW, ... Chan HC, et al. Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in the pathogenesis of hydrosalpinx induced by Chlamydia trachomatis infection. The Journal of Obstetrics and Gynaecology Research. 34: 923-30. PMID 19012687 DOI: 10.1111/J.1447-0756.2008.00826.X  0.648
2008 Wang Y, Guan X, Fok KL, Li S, Zhang X, Miao S, Zong S, Koide SS, Chan HC, Wang L. A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. Cellular and Molecular Life Sciences : Cmls. 65: 3822-9. PMID 18953687 DOI: 10.1007/s00018-008-8452-0  0.621
2008 Ajonuma LC, He Q, Sheung Chan PK, Yu Ng EH, Fok KL, Yan Wong CH, Tsang LL, Ho LS, Lau MC, Huang HY, Yang DZ, Rowlands DK, Tang XX, Zhang XH, Chung YW, ... Chan HC, et al. Involvement of cystic fibrosis transmembrane conductance regulator in infection-induced edema. Cell Biology International. 32: 801-6. PMID 18462959 DOI: 10.1016/J.Cellbi.2008.03.010  0.637
2008 Chen W, Xu W, Chen Z, Ni Y, Yuan Y, Zhou S, Li K, Tsang L, Chung YW, Shi Q, Chan HC. Cl- is required for HCO3- entry necessary for sperm capacitation:involvement of a Cl-/HCO3- exchanger(SLC26A3) and CFTR. Biology of Reproduction. 78: 187-187. DOI: 10.1093/Biolreprod/78.S1.187A  0.465
2008 Zhang XH, Rowlands DK, Ma ZG, Gou YL, Tsang LL, Wong HY, Fok KL, Chung YW, Mu L, Chan HC. Herbal extract ECBRC-AG and its active intgredient reduces HPA axis funtion by inhibiting PVN neurons activity through T-type calcium channels Cell Biology International. 32: S66-S67. DOI: 10.1016/J.Cellbi.2008.01.283  0.599
2008 Xu WM, Chen WY, Dong HS, Fok KL, Zhou CX, Zhu H, Yan Wong CH, Chan HC. The functional role of CFTR in spermatogenesis Cell Biology International. 32: S65-S65. DOI: 10.1016/J.Cellbi.2008.01.278  0.619
2007 Xu WM, Shi QX, Chen WY, Zhou CX, Ni Y, Rowlands DK, Yi Liu G, Zhu H, Ma ZG, Wang XF, Chen ZH, Zhou SC, Dong HS, Zhang XH, Chung YW, ... ... Chan HC, et al. Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility. Proceedings of the National Academy of Sciences of the United States of America. 104: 9816-21. PMID 17519339 DOI: 10.1073/Pnas.0609253104  0.512
2007 Yin X, Ouyang S, Xu W, Zhang X, Fok KL, Wong HY, Zhang J, Qiu X, Miao S, Chan HC, Wang L. YWK-II protein as a novel G(o)-coupled receptor for Müllerian inhibiting substance in cell survival. Journal of Cell Science. 120: 1521-8. PMID 17452623 DOI: 10.1242/Jcs.001230  0.641
2007 Xu W, Zhou C, Zhang X, Chen W, Zhu H, Chan HC. Bin1b IMMUNIZATION IN RATS RESULTS IN DECREASED SPERM MOTILITY WITH COMPROMISED FERTILIZING CAPACITY Biology of Reproduction. 77: 124-124. DOI: 10.1093/Biolreprod/77.S1.124A  0.426
2006 Shu C, Li TY, Tsang LL, Fok KL, Lo PS, Zhu JX, Ho LS, Chung YW, Chan HC. Differentiation of adult rat bone marrow stem cells into epithelial progenitor cells in culture. Cell Biology International. 30: 823-8. PMID 16877014 DOI: 10.1016/J.Cellbi.2006.06.004  0.641
2006 Chan HC, Shi QX, Zhou CX, Wang XF, Xu WM, Chen WY, Chen AJ, Ni Y, Yuan YY. Critical role of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Molecular and Cellular Endocrinology. 250: 106-13. PMID 16414184 DOI: 10.1016/j.mce.2005.12.032  0.551
2005 Yang JZ, Ajonuma LC, Rowlands DK, Tsang LL, Ho LS, Lam SY, Chen WY, Zhou CX, Chung YW, Cho CY, Tse JY, James AE, Chan HC. The role of inducible nitric oxide synthase in gamete interaction and fertilization: a comparative study on knockout mice of three NOS isoforms. Cell Biology International. 29: 785-91. PMID 16087361 DOI: 10.1016/j.cellbi.2005.05.005  0.486
2000 Chan LN, Wang XF, Tsang LL, Liu CQ, Chan HC. Suppression of CFTR-mediated Cl- secretion by enhanced expression of epithelial Na+ channels in mouse endometrial epithelium Biochemical and Biophysical Research Communications. 276: 40-44. PMID 11006079 DOI: 10.1006/Bbrc.2000.3426  0.362
2000 Chan LN, Wang XF, Tsang LL, Chan HC. Pyrimidinoceptors-mediated activation of Ca2+-dependent Cl- conductance in mouse endometrial epithelial cells Biochimica Et Biophysica Acta - Molecular Cell Research. 1497: 261-270. PMID 10903431 DOI: 10.1016/S0167-4889(00)00057-4  0.334
2000 Chan HC, Wu WL, So SC, Chung YW, Tsang LL, Wang XF, Yan YC, Luk SC, Siu SS, Tsui SK, Fung KP, Lee CY, Waye MM. Modulation of the Ca(2+)-activated Cl(-) channel by 14-3-3epsilon. Biochemical and Biophysical Research Communications. 270: 581-7. PMID 10753667 DOI: 10.1006/Bbrc.2000.2454  0.333
1998 Wu WL, So SC, Sun YP, Zhou TS, Yu Y, Chung YW, Wang XF, Bao YD, Yan YC, Chan HC. Functional expression of a Ca2+-activated K+ channel in Xenopus oocytes injected with RNAs from the rat testis. Biochimica Et Biophysica Acta. 1373: 360-5. PMID 9733997 DOI: 10.1016/S0005-2736(98)00119-9  0.304
1998 Wu WL, So SC, Sun YP, Chung YW, Grima J, Wong PY, Yan YC, Chan HC. Functional expression of P2U receptors in rat spermatogenic cells: dual modulation of a Ca(2+)-activated K+ channel. Biochemical and Biophysical Research Communications. 248: 728-32. PMID 9703995 DOI: 10.1006/Bbrc.1998.9051  0.329
1998 Chan HC, Lui KM, Wong WS, Poon AM. Effect of melatonin on chloride secretion by human colonic T84 cells. Life Sciences. 62: 2151-8. PMID 9627094 DOI: 10.1016/S0024-3205(98)00190-8  0.345
Low-probability matches (unlikely to be authored by this person)
1998 Leung PS, Wong TP, Wong PY, Chan HC. Localization and distribution of pituitary adenylate cyclase-activating polypeptide in the rat epididymis. Cell Biology International. 22: 193-8. PMID 9974213 DOI: 10.1006/Cbir.1998.0239  0.297
2003 Wang XF, Zhou CX, Shi QX, Yuan YY, Yu MK, Ajonuma LC, Ho LS, Lo PS, Tsang LL, Liu Y, Lam SY, Chan LN, Zhao WC, Chung YW, Chan HC. Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Nature Cell Biology. 5: 902-6. PMID 14515130 DOI: 10.1038/ncb1047  0.294
1997 Leung PS, Yao XQ, Chan HC, Fu LXM, Wong PYD. Differential Gene Expression Of Angiotensin Ii Receptor Subtypes In The Epididymides Of Mature And Immature Rats Life Sciences. 62: 461-468. PMID 9449237 DOI: 10.1016/S0024-3205(97)01140-5  0.289
2000 Kok LD, Wong YP, Wu TW, Chan HC, Kwok TT, Fung KP. Morin hydrate: a potential antioxidant in minimizing the free-radicals-mediated damage to cardiovascular cells by anti-tumor drugs. Life Sciences. 67: 91-9. PMID 10896033 DOI: 10.1016/S0024-3205(00)00605-6  0.283
2017 Huang W, Jin A, Zhang J, Wang C, Tsang LL, Cai Z, Zhou X, Chen H, Chan HC. Upregulation of CFTR in patients with endometriosis and its involvement in NFκB-uPAR dependent cell migration. Oncotarget. 8: 66951-66959. PMID 28978008 DOI: 10.18632/Oncotarget.16441  0.281
2017 Huang W, Jin A, Zhang J, Wang C, Tsang LL, Cai Z, Zhou X, Chen H, Chan HC. Upregulation of CFTR in patients with endometriosis and its involvement in NFκB-uPAR dependent cell migration. Oncotarget. PMID 28415617 DOI: 10.18632/oncotarget.16441  0.281
1997 Leung PS, Chan HC, Fu LX, Zhou WL, Wong PY. Angiotensin II receptors, AT1 and AT2 in the rat epididymis. Immunocytochemical and electrophysiological studies. Biochimica Et Biophysica Acta. 1357: 65-72. PMID 9202176 DOI: 10.1016/S0167-4889(97)00015-3  0.281
2006 Huang H, Chan H, Wang YY, Ouyang DY, Zheng YT, Tam SC. Trichosanthin suppresses the elevation of p38 MAPK, and Bcl-2 induced by HSV-1 infection in Vero cells. Life Sciences. 79: 1287-92. PMID 16725160 DOI: 10.1016/J.Lfs.2006.03.047  0.279
2010 Chen MH, Chen H, Zhou Z, Ruan YC, Wong HY, Lu YC, Guo JH, Chung YW, Huang PB, Huang HF, Zhou WL, Chan HC. Involvement of CFTR in oviductal HCO3- secretion and its effect on soluble adenylate cyclase-dependent early embryo development. Human Reproduction (Oxford, England). 25: 1744-54. PMID 20406739 DOI: 10.1093/humrep/deq094  0.278
2015 Chen H, Guo JH, Zhang XH, Chan HC. Defective CFTR-regulated granulosa cell proliferation in polycystic ovarian syndrome. Reproduction (Cambridge, England). 149: 393-401. PMID 25646509 DOI: 10.1530/REP-14-0368  0.272
2005 Wang YY, Ouyang DY, Huang H, Chan H, Tam SC, Zheng YT. Enhanced apoptotic action of trichosanthin in HIV-1 infected cells. Biochemical and Biophysical Research Communications. 331: 1075-80. PMID 15882987 DOI: 10.1016/J.Bbrc.2005.03.230  0.269
2020 Zhao M, Zhang J, Huang W, Dong J, Guo J, U KP, Weng Z, Liu S, Chan HC, Feng H, Jiang X. CFTR promotes malignant glioma development via up-regulation of Akt/Bcl2-mediated anti-apoptosis pathway. Journal of Cellular and Molecular Medicine. PMID 32463592 DOI: 10.1111/Jcmm.15300  0.265
2010 He Q, Tsang LL, Ajonuma LC, Chan HC. Abnormally up-regulated cystic fibrosis transmembrane conductance regulator expression and uterine fluid accumulation contribute to Chlamydia trachomatis-induced female infertility. Fertility and Sterility. 93: 2608-14. PMID 20227074 DOI: 10.1016/j.fertnstert.2010.01.040  0.258
1998 Leung PS, Chan HC, Wong PYD. Immunohistochemical localization of angiotensin II in the mouse pancreas. Histochemical Journal. 30: 21-25. PMID 9539203 DOI: 10.1023/A:1003210428276  0.255
2018 Liao H, Chen Y, Yulong L, Xue S, Liu M, Lin Z, Liu Y, Chan HC, Zhang X, Sun H. CFTR is required for the migration of Primordial Germ Cells during zebrafish early embryogenesis. Reproduction (Cambridge, England). PMID 29930176 DOI: 10.1530/REP-17-0681  0.255
2005 Ajonuma LC, Tsang LL, Zhang GH, Wong CH, Lau MC, Ho LS, Rowlands DK, Zhou CX, Ng CP, Chen J, Xu PH, Zhu JX, Chung YW, Chan HC. Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome. Molecular Endocrinology (Baltimore, Md.). 19: 3038-44. PMID 16051669 DOI: 10.1210/me.2005-0114  0.251
2014 Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC, Breton S. CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway. Journal of Cell Science. 127: 4396-408. PMID 25107366 DOI: 10.1242/Jcs.148098  0.25
1997 Chan HC, Law SH, Leung PS, Fu LXM, Wong PYD. Angiotensin II Receptor Type I-Regulated Anion Secretion in Cystic Fibrosis Pancreatic Duct Cells The Journal of Membrane Biology. 156: 241-249. PMID 9096065 DOI: 10.1007/S002329900204  0.241
2012 Chen J, Jiang XH, Chen H, Guo JH, Tsang LL, Yu MK, Xu WM, Chan HC. CFTR negatively regulates cyclooxygenase-2-PGE(2) positive feedback loop in inflammation. Journal of Cellular Physiology. 227: 2759-66. PMID 21913191 DOI: 10.1002/jcp.23020  0.24
2010 He Q, Chen H, Wong CH, Tsang LL, Chan HC. Regulatory mechanism underlying cyclic changes in mouse uterine bicarbonate secretion: role of estrogen. Reproduction (Cambridge, England). 140: 903-10. PMID 20876742 DOI: 10.1530/REP-10-0178  0.24
2017 Huang WQ, Guo JH, Yuan C, Cui YG, Diao FY, Yu MK, Liu JY, Ruan YC, Chan HC. Abnormal CFTR Affects Glucagon Production by Islet α Cells in Cystic Fibrosis and Polycystic Ovarian Syndrome. Frontiers in Physiology. 8: 835. PMID 29204121 DOI: 10.3389/fphys.2017.00835  0.24
1999 Chan LN, Chung YW, Leung PS, Liu CQ, Chan HC. Activation of an adenosine 3',5'-cyclic monophosphate-dependent Cl- conductance in response to neurohormonal stimuli in mouse endometrial epithelial cells: The role of cystic fibrosis transmembrane conductance regulator Biology of Reproduction. 60: 374-380. PMID 9916004 DOI: 10.1095/Biolreprod60.2.374  0.239
1997 Zhou WL, Leung PS, Wong TP, Dun NJ, Wong PY, Chan HC. Local regulation of epididymal anion secretion by pituitary adenylate cyclase-activating polypeptide. The Journal of Endocrinology. 154: 389-95. PMID 9379115 DOI: 10.1677/Joe.0.1540389  0.238
2007 Zhu JX, Yang N, Zhu H, Chung YW, Chan HC. Effect of NYD-SP27 down-regulation on ATP-induced Ca2+-dependent pancreatic duct anion secretion in cystic fibrosis cells. Cell Biology International. 31: 521-5. PMID 17196844 DOI: 10.1016/J.Cellbi.2006.11.021  0.237
2005 Ajonuma LC, Ng EH, Chow PH, Hung CY, Tsang LL, Cheung AN, Brito-Jones C, Lok IH, J Haines C, Chan HC. Increased cystic fibrosis transmembrane conductance regulator (CFTR) expression in the human hydrosalpinx. Human Reproduction (Oxford, England). 20: 1228-34. PMID 15705621 DOI: 10.1093/Humrep/Deh773  0.235
2017 Chen H, Chan HC. Amplification of FSH signaling by CFTR and nuclear soluble adenylyl cyclase in the ovary. Clinical and Experimental Pharmacology & Physiology. PMID 28345252 DOI: 10.1111/1440-1681.12756  0.231
2010 Zhang WK, Wang D, Duan Y, Loy MM, Chan HC, Huang P. Mechanosensitive gating of CFTR. Nature Cell Biology. 12: 507-12. PMID 20400957 DOI: 10.1038/Ncb2053  0.229
1992 Chan HC, Goldstein J, Nelson DJ. Alternate pathways for chloride conductance activation in normal and cystic fibrosis airway epithelial cells American Journal of Physiology - Cell Physiology. 262. PMID 1317104  0.228
2004 Yang JZ, Ajonuma LC, Tsang LL, Lam SY, Rowlands DK, Ho LS, Zhou CX, Chung YW, Chan HC. Differential expression and localization of CFTR and ENaC in mouse endometrium during pre-implantation. Cell Biology International. 28: 433-9. PMID 15223019 DOI: 10.1016/j.cellbi.2004.03.011  0.227
2006 Ouyang DY, Chan H, Wang YY, Huang H, Tam SC, Zheng YT. An inhibitor of c-Jun N-terminal kinases (CEP-11004) counteracts the anti-HIV-1 action of trichosanthin. Biochemical and Biophysical Research Communications. 339: 25-9. PMID 16289100 DOI: 10.1016/J.Bbrc.2005.11.004  0.226
1992 Chan HC, Kaetzel MA, Nelson DJ, Hazarika P, Dedman JR. Antibody against a cystic fibrosis transmembrane conductance regulator-derived synthetic peptide inhibits anion currents in human colonie cell line T84 Journal of Biological Chemistry. 267: 8411-8416. PMID 1373728  0.225
2001 Rowlands DK, Tsang LL, Cui YG, Chung YW, Chan LN, Liu CQ, James T, Chan HC. Upregulation of cystic fibrosis transmembrane conductance regulator expression by oestrogen and Bak Foong Pill in mouse uteri Cell Biology International. 25: 1033-1035. PMID 11589624 DOI: 10.1006/cbir.2001.0746  0.22
2012 Chen H, Ruan YC, Xu WM, Chen J, Chan HC. Regulation of male fertility by CFTR and implications in male infertility. Human Reproduction Update. 18: 703-13. PMID 22709980 DOI: 10.1093/humupd/dms027  0.219
2001 Wang XF, Tsang LL, So SC, Chan HC. Suppression of ATP-induced Cl(-)secretion by enhanced expression of epithelial Na(+)channels in mouse endometrial epithelium. Cell Biology International. 25: 1017-20. PMID 11589620 DOI: 10.1006/cbir.2001.0754  0.217
2001 Leung PS, So SC, Lam SY, Tsang LL, Chung YW, Chan HC. Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells. Cell Biology International. 25: 123-9. PMID 11237416 DOI: 10.1006/Cbir.2000.0584  0.217
1998 Leung PS, Chan HC, Chung YW, Wong TP, Wong PY. The role of local angiotensins and prostaglandins in the control of anion secretion by the rat epididymis. Journal of Reproduction and Fertility. Supplement. 53: 15-22. PMID 10645262  0.217
2004 Tsang LL, Chan LN, Chan HC. Altered cyclic expression of epithelial Na+ channel subunits and cystic fibrosis transmembrane conductance regulator in mouse endometrium by a low sodium diet Cell Biology International. 28: 549-555. PMID 15261163 DOI: 10.1016/j.cellbi.2004.04.011  0.216
2010 Tang XX, Chen H, Yu S, Zhang L, Caplan MJ, Chan HC. Lymphocytes accelerate epithelial tight junction assembly: role of AMP-activated protein kinase (AMPK). Plos One. 5: e12343. PMID 20808811 DOI: 10.1371/Journal.Pone.0012343  0.216
2001 Jiang JL, Zhou Q, Yu MK, Ho LS, Chen ZN, Chan HC. The Involvement of HAb18G/CD147 in Regulation of Store-operated Calcium Entry and Metastasis of Human Hepatoma Cells Journal of Biological Chemistry. 276: 46870-46877. PMID 11591720 DOI: 10.1074/jbc.M108291200  0.215
2010 Yi S, Zhang X, Chen J, Chen W, Tsang LL, Gou YL, Chung YW, Chan HC. CFTR in epithelial cells plays a key role in maintaining lymphocytes survivalin vitro Cell Biology International. 34: S6-S6. DOI: 10.1042/cbi034s006c  0.215
2004 Zhou CX, Zhang YL, Xiao L, Zheng M, Leung KM, Chan MY, Lo PS, Tsang LL, Wong HY, Ho LS, Chung YW, Chan HC. An epididymis-specific beta-defensin is important for the initiation of sperm maturation. Nature Cell Biology. 6: 458-64. PMID 15122269 DOI: 10.1038/ncb1127  0.213
1994 Kaetzel MA, Chan HC, Dubinsky WP, Dedman JR, Nelson DJ. A role for annexin IV in epithelial cell function: Inhibition of calcium-activated chloride conductance Journal of Biological Chemistry. 269: 5297-5302. PMID 8106514  0.213
2014 Jin A, Chen H, Wang C, Tsang LL, Jiang X, Cai Z, Chan HC, Zhou X. Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells. Fertility and Sterility. 101: 1681-7.e1. PMID 24661733 DOI: 10.1016/j.fertnstert.2014.02.007  0.213
1996 Chan HC, Cheung WT, Leung PY, Wu LJ, Cheng Chew SB, Ko WH, Wong PYD. Purinergic regulation of anion secretion by cystic fibrosis pancreatic duct cells American Journal of Physiology - Cell Physiology. 271. PMID 8769985  0.212
2017 Huang WQ, Guo JH, Zhang XH, Yu MK, Chung YW, Ruan YC, Chan HC. Glucose-Sensitive CFTR Suppresses Glucagon Secretion by Potentiating KATP Channels in Pancreatic Islet α Cells. Endocrinology. 158: 3188-3199. PMID 28977595 DOI: 10.1210/en.2017-00282  0.212
2018 Sun H, Wang Y, Zhang J, Chen Y, Liu Y, Lin Z, Liu M, Sheng K, Liao H, Tsang KS, Zhang X, Jiang X, Xu W, Mao M, Chan HC. CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis. Cell Death & Disease. 9: 275. PMID 29449653 DOI: 10.1038/S41419-018-0311-9  0.209
2008 Chen H, Chen MH, Zhou WL, Chan HC. Expression of CFTR in mouse oocytes and its involvement in oocyte maturation Cell Biology International. 32: S41-S41. DOI: 10.1016/j.cellbi.2008.01.177  0.209
1999 Cheung CY, Wang XF, Chan HC. Stimulation of HCO3- secretion across cystic fibrosis pancreatic duct cells by extracellular ATP. Biological Signals and Receptors. 7: 321-7. PMID 9873153 DOI: 10.1159/000014555  0.209
2007 Zhou WL, Zuo WL, Ruan YC, Wang Z, DU JY, Xiong Y, Chan HC. The role of extracellular ATP in the male reproductive tract. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 59: 487-94. PMID 17700968  0.208
2010 Yu L, Tang H, Jiang XH, Tsang LL, Chung YW, Chan HC. Involvement of calpain-I and microRNA34 in kanamycin-induced apoptosis of inner ear cells. Cell Biology International. 34: 1219-25. PMID 21067520 DOI: 10.1042/CBI20100515  0.208
1998 Fong SK, Chan HC. Regulation of anion secretion by prostaglandin E2 in the mouse endometrial epithelium. Biology of Reproduction. 58: 1020-5. PMID 9546734 DOI: 10.1095/biolreprod58.4.1020  0.207
2008 Yang ZH, Yu HJ, Pan A, Du JY, Ruan YC, Ko WH, Chan HC, Zhou WL. Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model. Plos One. 3: e3348. PMID 18833323 DOI: 10.1371/Journal.Pone.0003348  0.207
2016 Liu Z, Guo J, Wang Y, Weng Z, Huang B, Yu MK, Zhang X, Yuan P, Zhao H, Chan WY, Jiang X, Chan HC. CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death and Differentiation. PMID 27834953 DOI: 10.1038/cdd.2016.118  0.205
2015 Wang C, Jin A, Huang W, Tsang LL, Cai Z, Zhou X, Chen H, Chan HC. Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis. The Journal of Clinical Endocrinology and Metabolism. 100: E955-63. PMID 25996258 DOI: 10.1210/jc.2015-1431  0.205
2005 Zhu JX, Zhang GH, Yang N, Rowlands DK, Wong HY, Tsang LL, Chung YW, Chan HC. Activation of apical CFTR and basolateral Ca(2+)-activated K+ channels by tetramethylpyrazine in Caco-2 cell line. European Journal of Pharmacology. 510: 187-95. PMID 15763242 DOI: 10.1016/j.ejphar.2005.01.026  0.204
2013 Chen H, Kui C, Chan HC. Ca(2+) mobilization in cumulus cells: role in oocyte maturation and acrosome reaction. Cell Calcium. 53: 68-75. PMID 23218669 DOI: 10.1016/j.ceca.2012.11.007  0.204
2018 Zhang J, Wang Y, Jiang X, Chan HC. Cystic fibrosis transmembrane conductance regulator-emerging regulator of cancer. Cellular and Molecular Life Sciences : Cmls. PMID 29411041 DOI: 10.1007/S00018-018-2755-6  0.203
1992 Chan HC, Nelson DJ. Chloride-dependent cation conductance activated during cellular shrinkage Science. 257: 669-671. PMID 1379742  0.202
2002 Zhu JX, Lo PS, Zhao WC, Tang N, Zhou Q, Rowlands DK, Gou YL, Chung YW, Chan HC. Bak Foong Pills stimulate anion secretion across normal and cystic fibrosis pancreatic duct epithelia. Cell Biology International. 26: 1011-8. PMID 12468376 DOI: 10.1006/cbir.2002.0960  0.202
2016 Tu Z, Chen Q, Zhang JT, Jiang X, Xia Y, Chan HC. CFTR is a potential marker for nasopharyngeal carcinoma prognosis and metastasis. Oncotarget. PMID 27769067 DOI: 10.18632/oncotarget.12762  0.202
2017 Zhang JT, Wang Y, Chen JJ, Zhang XH, Dong JD, Tsang LL, Huang XR, Cai Z, Lan HY, Jiang XH, Chan HC. Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis. Scientific Reports. 7: 5233. PMID 28701694 DOI: 10.1038/S41598-017-05435-5  0.201
1999 Cheng HS, So SC, Law SH, Chan HC. Angiotensin II-mediated signal transduction events in cystic fibrosis pancreatic duct cells. Biochimica Et Biophysica Acta. 1449: 254-60. PMID 10209304  0.2
2012 Chen H, Lam Fok K, Jiang X, Chan HC. New insights into germ cell migration and survival/apoptosis in spermatogenesis: Lessons from CD147. Spermatogenesis. 2: 264-272. PMID 23248767 DOI: 10.4161/spmg.22014  0.2
2015 Lo IC, Chan HC, Qi Z, Ng KL, So C, Tsang SY. TRPV3 Channel Negatively Regulates Cell Cycle Progression and Safeguards the Pluripotency of Embryonic Stem Cells. Journal of Cellular Physiology. PMID 26130157 DOI: 10.1002/jcp.25086  0.199
1993 Chan HC, Fu WO, Chung YW, Huang SJ, Zhou TS, Wong PY. Characterization of a swelling-induced chloride conductance in cultured rat epididymal cells. The American Journal of Physiology. 265: C997-1005. PMID 7694476 DOI: 10.1152/ajpcell.1993.265.4.C997  0.199
2009 Chen H, Tsang LL, Chan HC. CFTR-Dependent Regulation of Estrogen Production in Ovarian Granulosa Cells. Biology of Reproduction. 81: 510-510. DOI: 10.1093/biolreprod/81.s1.510  0.198
2004 Jiang JL, Chan HC, Zhou Q, Yu MK, Yao XY, Lam SY, Zhu H, Ho LS, Leung KM, Chen ZN. HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains. Cellular and Molecular Life Sciences : Cmls. 61: 2083-91. PMID 15316657 DOI: 10.1007/S00018-004-4146-4  0.197
2003 Yang JZ, Ho AL, Ajonuma LC, Lam SY, Tsang LL, Tang N, Rowlands DK, Gou YL, Chung YW, Chan HC. Differential effects of Matrigel and its components on functional activity of CFTR and ENaC in mouse endometrial epithelial cells. Cell Biology International. 27: 543-8. PMID 12842093 DOI: 10.1016/S1065-6995(03)00079-9  0.197
2014 Chan HC, He Q, Ajonuma LC, Wang XF. Epithelial ion channels in the regulation of female reproductive tract fluid microenvironment: implications in fertility and infertility. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 59: 495-504. PMID 17700969  0.197
1997 Chan HC, Liu CQ, Fong SK, Law SH, Wu LJ, So E, Chung YW, Ko WH, Wong PY. Regulation of Cl- secretion by extracellular ATP in cultured mouse endometrial epithelium. The Journal of Membrane Biology. 156: 45-52. PMID 9070463  0.195
1995 Chan HC, Zhou WL, Wong PY. Extracellular ATP activates both Ca(2+)- and cAMP-dependent Cl- conductances in rat epididymal cells. The Journal of Membrane Biology. 147: 185-93. PMID 8568854  0.194
1994 Lai KB, Fu WO, Ko WH, Chan HC, Wong PY. The effect of [Arg8]vasopressin on electrogenic chloride secretion in cultured rat epididymal epithelia. The American Journal of Physiology. 267: C607-16. PMID 8074193 DOI: 10.1152/ajpcell.1994.267.2.C607  0.193
1994 Chan HC, Kaetzel MA, Gotter AL, Dedman JR, Nelson DJ. Annexin IV Inhibits Calmodulin-dependent Protein Kinase II-activated Chloride Conductance: A Novel Mechanism for Ion Channel Regulation Journal of Biological Chemistry. 269: 32464-32468. PMID 7798247  0.193
2001 Wang XF, Chan HC. Adenosine triphosphate induces inhibition of Na(+) absorption in mouse endometrial epithelium: a Ca(2+)-dependent mechanism. Biology of Reproduction. 63: 1918-24. PMID 11090466 DOI: 10.1095/biolreprod63.6.1918  0.192
2015 Dong J, Jiang X, Zhang X, Liu KS, Zhang J, Chen J, Yu MK, Tsang LL, Chung YW, Wang Y, Zhou WL, Chan HC. Dynamically Regulated CFTR Expression and Its Functional Role in Cutaneous Wound Healing. Journal of Cellular Physiology. 230: 2049-58. PMID 25641604 DOI: 10.1002/Jcp.24931  0.192
2017 Chen R, Lee WY, Zhang XH, Zhang JT, Lin S, Xu LL, Huang B, Yang FY, Liu HL, Wang B, Tsang LL, Willaime-Morawek S, Li G, Chan HC, Jiang X. Epigenetic Modification of the CCL5/CCR1/ERK Axis Enhances Glioma Targeting in Dedifferentiation-Reprogrammed BMSCs. Stem Cell Reports. PMID 28216148 DOI: 10.1016/J.Stemcr.2017.01.016  0.188
2002 Chan LN, Tsang LL, Rowlands DK, Rochelle LG, Boucher RC, Liu CQ, Chan HC. Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tract Journal of Membrane Biology. 185: 165-176. PMID 11891575 DOI: 10.1007/s00232-001-0117-y  0.186
2012 Zhou CX, Wang XF, Chan HC. Bicarbonate secretion by the female reproductive tract and its impact on sperm fertilizing capacity. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 57: 115-24. PMID 15830094  0.186
1996 Chan HC, Ko WH, Zhao W, Fu WO, Wong PY. Evidence for independent Cl- and HCO3- secretion and involvement of an apical Na(+)-HCO3- cotransporter in cultured rat epididymal epithelia. Experimental Physiology. 81: 515-24. PMID 8737084 DOI: 10.1113/expphysiol.1996.sp003954  0.185
1995 Chan HC, Lai KB, Fu WO, Chung YW, Chan PS, Wong PY. Regional differences in bioelectrical properties and anion secretion in cultured epithelia from rat and human male excurrent ducts. Biology of Reproduction. 52: 192-8. PMID 7711178 DOI: 10.1095/biolreprod52.1.192  0.185
1998 Chan HC, Wu WL, Sun YP, Leung PS, Wong TP, Chung YW, So SC, Zhou TS, Yan YC. Expression of sperm Ca2+-activated K+ channels in Xenopus oocytes and their modulation by extracellular ATP. Febs Letters. 438: 177-82. PMID 9827541 DOI: 10.1016/S0014-5793(98)01298-8  0.185
2003 Tang N, Zhu JX, Zhao WC, Xing Y, Gou YL, Rowlands DK, Chung YW, Chan HC. Effect of Bak Foong pills on exocrine pancreatic-bile secretion. Biological & Pharmaceutical Bulletin. 26: 1384-7. PMID 14519940 DOI: 10.1248/BPB.26.1384  0.184
2001 Tsang LL, Chan LN, Wang XF, So SC, Yuen JPS, Fiscus RR, Chan HC. Enhanced epithelial Na+ channel (ENaC) activity in mouse endometrial epithelium by upregulation of γENaC subunit Japanese Journal of Physiology. 51: 539-543. PMID 11564291 DOI: 10.2170/jjphysiol.51.539  0.184
1995 Chan HC, Hon FK, Wong PY. Stimulatory and inhibitory effects of a phorbol ester on chloride secretion by rat epididymal epithelium. Biology of Reproduction. 52: 638-44. PMID 7756457  0.184
2002 Leung PS, Wong TP, Chung YW, Chan HC. Androgen dependent expression of AT1 receptor and its regulation of anion secretion in rat epididymis. Cell Biology International. 26: 117-22. PMID 11779228 DOI: 10.1006/Cbir.2001.0830  0.183
2015 Xie C, Sun X, Chen J, Ng CF, Lau KM, Cai Z, Jiang X, Chan HC. Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. Journal of Cellular Physiology. 230: 1906-15. PMID 25546515 DOI: 10.1002/jcp.24921  0.183
2001 Tsang LL, Chan LN, Liu CQ, Chan HC. Effect of phenol red and steroid hormones on cystic fibrosis transmembrane conductance regulator in mouse endometrial epithelial cells Cell Biology International. 25: 1021-1024. PMID 11589621 DOI: 10.1006/cbir.2001.0752  0.183
1998 Fong SK, Liu CQ, Chan HC. Cellular mechanisms of adrenaline-stimulated anion secretion by the mouse endometrial epithelium. Biology of Reproduction. 59: 1342-8. PMID 9828177 DOI: 10.1095/biolreprod59.6.1342  0.182
2016 Liu K, Zhang X, Zhang JT, Tsang LL, Jiang X, Chan HC. Defective CFTR- β-catenin interaction promotes NF-κB nuclear translocation and intestinal inflammation in cystic fibrosis. Oncotarget. PMID 27588407 DOI: 10.18632/oncotarget.11747  0.182
2022 Liu M, Lin Z, Wang Y, Zhang J, Zhou M, Tsang KS, Liao H, Chen Y, Liu Y, Zhang X, Chan HC, Sun H. High cystic fibrosis transmembrane conductance regulator expression in childhood B-cell acute lymphoblastic leukemia acts as a potential therapeutic target. Translational Cancer Research. 11: 436-443. PMID 35402186 DOI: 10.21037/tcr-21-2296  0.182
2010 Zhang JT, Chung CM, Chan HC. Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial-mesenchymal transition during cancer development Cell Biology International. 34: S7-S7. DOI: 10.1042/cbi034s007a  0.18
2016 Zhang JT, Weng ZH, Tsang KS, Tsang LL, Chan HC, Jiang XH. MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells. Plos One. 11: e0148062. PMID 26815535 DOI: 10.1371/Journal.Pone.0148062  0.18
2005 He Q, Zhu JX, Xing Y, Tsang LL, Yang N, Rowlands DK, Chung YW, Chan HC. Tetramethylpyrazine stimulates cystic fibrosis transmembrane conductance regulator-mediated anion secretion in distal colon of rodents. World Journal of Gastroenterology : Wjg. 11: 4173-9. PMID 16015685  0.18
2020 Liu Y, Lin Z, Liu M, Liao H, Chen Y, Zhang X, Chan HC, Zhou B, Rao L, Sun H. CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy. Mechanisms of Development. 103627. PMID 32574800 DOI: 10.1016/j.mod.2020.103627  0.179
2019 Qiu Z, Guo J, Kala S, Zhu J, Xian Q, Qiu W, Li G, Zhu T, Meng L, Zhang R, Chan HC, Zheng H, Sun L. The Mechanosensitive Ion Channel Piezo1 Significantly Mediates In Vitro Ultrasonic Stimulation of Neurons. Iscience. 21: 448-457. PMID 31707258 DOI: 10.1016/j.isci.2019.10.037  0.179
2005 Ajonuma L, Tsang L, Zhang G, Wong C, Chung Y, Chan H. Involvement of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in the Pathogenesis of Ovarian Hyperstimulation Syndrome Fertility and Sterility. 84: S441. DOI: 10.1016/J.FERTNSTERT.2005.07.1154  0.179
2005 Zhao WC, Zhu JX, Zhang GH, Wong CH, Chung YW, Chan HC. Effect of sodium ferulate on human colonic anion secretion and the underlying signaling mechanism. Biological & Pharmaceutical Bulletin. 28: 1608-11. PMID 16141524 DOI: 10.1248/BPB.28.1608  0.178
1999 Wong PYD, Chan HC, Leung PS, Chung YW, Wong YL, Lee WM, Ng V, Dun NJ. Regulation of anion secretion by cyclo-oxygenase and prostanoids in cultured epididymal epithelia from the rat. The Journal of Physiology. 514: 809-820. PMID 9882752 DOI: 10.1111/J.1469-7793.1999.809Ad.X  0.177
2008 Chen WY, Xu WM, Yan Wong CH, Chung YW, Chan HC. The expression of SLC26A3 in the tesitis and sperm and its role in sperm capacitation Cell Biology International. 32: S53-S54. DOI: 10.1016/j.cellbi.2008.01.228  0.177
1999 Cheng HS, Wong WS, Chan KT, Wang XF, Wang ZD, Chan HC. Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells. Biochimica Et Biophysica Acta. 1418: 31-8. PMID 10209208 DOI: 10.1016/S0005-2736(99)00011-5  0.177
2019 Liu M, Liao H, Chen Y, Lin Z, Liu Y, Zhang X, Chan HC, Sun H. Treatment of human T-cell acute lymphoblastic leukemia cells with CFTR inhibitor CFTRinh-172. Leukemia Research. 86: 106225. PMID 31541940 DOI: 10.1016/j.leukres.2019.106225  0.177
1998 So SC, Wu WL, Grima J, Leung PS, Chung YW, Cheng CY, Wong PY, Yan YC, Chan HC. Functional expression of sperm angiotensin II type I receptor in Xenopus oocyte: modulation of a sperm Ca2+-activated K+ channel. Biochimica Et Biophysica Acta. 1415: 261-5. PMID 9858746 DOI: 10.1016/S0005-2736(98)00201-6  0.176
2011 Yu L, Jiang XH, Zhou Z, Tsang LL, Yu MK, Chung YW, Zhang XH, Wang AM, Tang H, Chan HC. A protective mechanism against antibiotic-induced ototoxicity: role of prestin. Plos One. 6: e17322. PMID 21364896 DOI: 10.1371/journal.pone.0017322  0.176
2005 Jia RR, Gou YL, Ho LS, Ng CP, Tan NH, Chan HC. Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells. Cell Biology International. 29: 835-42. PMID 16154779 DOI: 10.1016/j.cellbi.2005.03.025  0.175
2002 Wang XF, Yu MK, Leung KM, Yip CY, Ko WH, Liu CQ, Chan HC. Involvement of Na+-HCO3- cotransporter in mediating cyclic adenosine 3',5'-monophosphate-dependent HCO3- secretion by mouse endometrial epithelium. Biology of Reproduction. 66: 1846-52. PMID 12021071  0.175
2009 Bi Y, Xu WM, Wong HY, Zhu H, Zhou ZM, Chan HC, Sha JH. NYD-SP27, a novel intrinsic decapacitation factor in sperm. Asian Journal of Andrology. 11: 229-39. PMID 19252507 DOI: 10.1038/aja.2009.6  0.174
2011 Yang JZ, Jiang X, Dong J, Guo J, Chen H, Tsang LL, Chung YW, Zhang X, Chan HC. Abnormally enhanced cystic fibrosis transmembrane conductance regulator-mediated apoptosis in endometrial cells contributes to impaired embryo implantation in controlled ovarian hyperstimulation. Fertility and Sterility. 95: 2100-6, 2106.e1-2. PMID 21420082 DOI: 10.1016/j.fertnstert.2011.02.036  0.174
1995 Chan HC, Zhou WL, Fu WO, Ko WH, Wong PY. Different regulatory pathways involved in ATP-stimulated chloride secretion in rat epididymal epithelium. Journal of Cellular Physiology. 164: 271-6. PMID 7622576 DOI: 10.1002/jcp.1041640207  0.174
2011 Xu W, Hui C, Yu SS, Jing C, Chan HC. MicroRNAs and cystic fibrosis--an epigenetic perspective. Cell Biology International. 35: 463-6. PMID 21476987 DOI: 10.1042/CBI20100664  0.173
2015 Liu XM, Chan HC, Ding GL, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, Qu F, Liu Y, Lu YC, Adashi EY, Sheng JZ, et al. FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+)/CREB pathway. Aging Cell. 14: 409-20. PMID 25754247 DOI: 10.1111/acel.12331  0.173
2017 Chen K, Liu Q, Tsang LL, Ye Q, Chan HC, Sun Y, Jiang X. Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/β-catenin/Slug pathway. Cell Death & Disease. 8: e2819. PMID 28542126 DOI: 10.1038/cddis.2017.138  0.172
2017 Liu Y, Xu J, Xu L, Wu T, Sun Y, Lee YW, Wang B, Chan HC, Jiang X, Zhang J, Li G. Cystic fibrosis transmembrane conductance regulator mediates tenogenic differentiation of tendon-derived stem cells and tendon repair: accelerating tendon injury healing by intervening in its downstream signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28495756 DOI: 10.1096/fj.201601181R  0.172
2003 Ajonuma LC, Ng EH, Chan HC. New insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcome. Human Reproduction Update. 8: 255-64. PMID 12078836 DOI: 10.1093/HUMUPD/8.3.255  0.172
2017 Chen JJ, Wang Y, Meng X, Ruan YC, Zou F, Chan HC. MRP4 regulates ENaC-dependent CREB/COX-2/PGE2 signaling during embryo implantation. Oncotarget. 8: 78520-78529. PMID 29108246 DOI: 10.18632/oncotarget.19676  0.172
2017 Chen JJ, Wang Y, Meng X, Ruan YC, Zou F, Chan HC. MRP4 regulates ENaC-dependent CREB/COX-2/PGE2 signaling during embryo implantation. Oncotarget. PMID 28775242 DOI: 10.18632/oncotarget.19676  0.172
2015 Li J, Zhang JT, Jiang X, Shi X, Shen J, Feng F, Chen J, Liu G, He P, Jiang J, Tsang LL, Wang Y, Rosell R, Jiang L, He J, ... Chan HC, et al. The cystic fibrosis transmembrane conductance regulator as a biomarker in non-small cell lung cancer. International Journal of Oncology. 46: 2107-15. PMID 25760446 DOI: 10.3892/ijo.2015.2921  0.171
2003 Ajonuma LC, Chan LN, Ng EH, Chow PH, Kung LS, Cheung AN, Briton-Jones C, Lok IH, Haines CJ, Chan HC. Characterization of epithelial cell culture from human hydrosalpinges and effects of its conditioned medium on embryo development and sperm motility. Human Reproduction (Oxford, England). 18: 291-8. PMID 12571164 DOI: 10.1093/humrep/deg078  0.17
1995 Chan HC, Fu WO, Chung YW, Chan PS, Wong PY. An ATP-activated cation conductance in human epididymal cells. Biology of Reproduction. 52: 645-52. PMID 7538800  0.169
2014 Chan HC, Jiang X, Ruan YC. Emerging role of cystic fibrosis transmembrane conductance regulator as an epigenetic regulator: linking environmental cues to microRNAs. Clinical and Experimental Pharmacology & Physiology. 41: 615-22. PMID 24909068 DOI: 10.1111/1440-1681.12271  0.169
2003 Chan HC, Kuo SC, Huang LJ, Liu CH, Hsu SL. A phenylacetate derivative, SCK6, inhibits cell proliferation via G1 cell cycle arrest and apoptosis. European Journal of Pharmacology. 467: 31-9. PMID 12706452 DOI: 10.1016/s0014-2999(03)01596-6  0.169
2012 Chan HC, Chen H, Ruan Y, Sun T. Physiology and pathophysiology of the epithelial barrier of the female reproductive tract: role of ion channels. Advances in Experimental Medicine and Biology. 763: 193-217. PMID 23397626 DOI: 10.1007/978-1-4614-4711-5_10  0.168
2020 Kakino A, Fujita Y, Ke LY, Chan HC, Tsai MH, Dai CY, Chen CH, Sawamura T. Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects. Journal of Lipid Research. 62: 100001. PMID 33410750 DOI: 10.1194/jlr.RA120000767  0.167
2016 Tzang BS, Chiang SY, Chan HC, Liu CH, Hsu TC. Human parvovirus B19 antibodies induce altered membrane protein expression and apoptosis of BeWo trophoblasts. Molecular Medicine Reports. PMID 27748859 DOI: 10.3892/mmr.2016.5787  0.167
1998 Ko WH, Chan HC, Chew SB, Wong PY. Regulated anion secretion in cultured epithelia from Sertoli cells of immature rats. The Journal of Physiology. 471-80. PMID 9763636 DOI: 10.1111/j.1469-7793.1998.471be.x  0.167
2014 Sun TT, Wang Y, Cheng H, Xiao HZ, Xiang JJ, Zhang JT, Yu SB, Martin TA, Ye L, Tsang LL, Jiang WG, Xiaohua J, Chan HC. Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer. Biochimica Et Biophysica Acta. 1843: 618-28. PMID 24373847 DOI: 10.1016/j.bbamcr.2013.12.013  0.167
2007 Ajonuma L, Tsang L, Chung Y, Wong C, Ho L, Chan H. Molecular and cellular mechanisms underlying ovarian hyperstimulation syndrome (OHSS): The role of cystic fibrosis transmembrane conductance regulator gene Fertility and Sterility. 88: S164-S165. DOI: 10.1016/j.fertnstert.2007.07.571  0.166
2011 Sun TT, Chung CM, Chan HC. Acrosome reaction in the cumulus oophorus revisited: involvement of a novel sperm-released factor NYD-SP8. Protein & Cell. 2: 92-8. PMID 21380641 DOI: 10.1007/s13238-011-1022-5  0.166
2008 Ruan YC, Zhou Z, Zhou WL, Chan HC. Involvement of epithelial sodium channel in the release of PGE2 from cultured endometrial epithelial cells of mice Cell Biology International. 32: S45-S45. DOI: 10.1016/j.cellbi.2008.01.193  0.166
2009 Chen J, Ng CP, Tsang LL, Ho LS, Xu PH, Rowlands DK, Gao JY, Chung YW, Li TY, Chan HC. Altered expression of inflammatory cytokine receptors in response to LPS challenge through interaction between intestinal epithelial cells and lymphocytes of Peyer's patch. Cell Biology International. 33: 369-75. PMID 19385035 DOI: 10.1016/j.cellbi.2009.01.004  0.165
2003 Zhou Q, Kwan HY, Chan HC, Jiang JL, Tam SC, Yao X. Blockage of voltage-gated K+ channels inhibits adhesion and proliferation of hepatocarcinoma cells. International Journal of Molecular Medicine. 11: 261-6. PMID 12525889  0.164
1998 Cheng HS, Leung PY, Cheng Chew SB, Leung PS, Lam SY, Wong WS, Wang ZD, Chan HC. Concurrent and independent HCO3- and Cl- secretion in a human pancreatic duct cell line (CAPAN-1). The Journal of Membrane Biology. 164: 155-67. PMID 9662559 DOI: 10.1007/S002329900401  0.164
2007 Wong AO, Chuk MC, Chan HC, Lee EK. Mechanisms for gonadotropin-releasing hormone potentiation of growth hormone rebound following norepinephrine inhibition in goldfish pituitary cells. American Journal of Physiology. Endocrinology and Metabolism. 292: E203-14. PMID 16940469 DOI: 10.1152/ajpendo.00337.2006  0.164
2018 Liu Y, Feng L, Wang H, Wang YJ, Chan HC, Jiang XH, Fu WM, Li G, Zhang JF. Identification of an Anti-inflammation Protein, Annexin A1, in Tendon Derived Stem Cells (TDSCs) of Cystic Fibrosis Mice: A Comparative Proteomic Analysis. Proteomics. Clinical Applications. e1700162. PMID 29781578 DOI: 10.1002/prca.201700162  0.163
2008 Zhou Z, Yu L, Huang SY, Zou XQ, Chan HC. Two herbal compounds as potentiators for cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels Cell Biology International. 32: S48-S48. DOI: 10.1016/j.cellbi.2008.01.205  0.161
2013 Chan HC. Letter from the editor: CFTR and male fertility-Impact beyond cystic fibrosis. Spermatogenesis. 3: e26228. PMID 24380037 DOI: 10.4161/spmg.26228  0.161
2020 Chan HC, Lau YT, Ding Q, Li CK, Wong CM, Shaw PC, Waye MMY, Tsang SY. PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells. Journal of the American Heart Association. 9: e010240. PMID 32157956 DOI: 10.1161/Jaha.118.010240  0.16
2001 Chan LN, Wang XF, Tsang LL, So SC, Chung YW, Liu CQ, Chan HC. Inhibition of amiloride-sensitive Na(+) absorption by activation of CFTR in mouse endometrial epithelium. Pflugers Archiv : European Journal of Physiology. 443: S132-6. PMID 11845319 DOI: 10.1007/s004240100660  0.16
2012 Zhang J, Dong J, Gu H, Yu S, Zhang X, Gou Y, Xu W, Burd A, Huang L, Miyado K, Huang Y, Chan HC. CD9 is critical for cutaneous wound healing through JNK signaling. The Journal of Investigative Dermatology. 132: 226-36. PMID 21881583 DOI: 10.1038/jid.2011.268  0.16
2016 Zhang Y, Xu J, Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, Chen S, Feng JQ, Chow DH, Xie X, Zheng L, ... ... Chan HC, et al. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nature Medicine. PMID 27571347 DOI: 10.1038/Nm.4162  0.16
1996 Ko WH, Chan HC, Chew SB, Wong PY. Ionic mechanisms of Ca(2+)-dependent electrolyte transport across equine sweat gland epithelium. The Journal of Physiology. 885-94. PMID 8799908 DOI: 10.1113/jphysiol.1996.sp021431  0.159
2018 Lin C, Chen PY, Chan HC, Huang YP, Chang NW. Peroxisome proliferator-activated receptor alpha accelerates neuronal differentiation and this might involve the mitogen-activated protein kinase pathway. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. PMID 30157453 DOI: 10.1016/j.ijdevneu.2018.08.006  0.159
2003 Wang XF, Yu MK, Lam SY, Leung KM, Jiang JL, Leung PS, Ko WH, Leung PY, Chew SB, Liu CQ, Tse CM, Chan HC. Expression, immunolocalization, and functional activity of Na+/H+ exchanger isoforms in mouse endometrial epithelium. Biology of Reproduction. 68: 302-8. PMID 12493726 DOI: 10.1095/Biolreprod.102.005645  0.158
2004 Zhu JX, Yang N, He Q, Tsang LL, Zhao WC, Chung YW, Chan HC. Differential Cl- and HCO3- mediated anion secretion by different colonic cell types in response to tetromethylpyrazine. World Journal of Gastroenterology : Wjg. 10: 1763-8. PMID 15188502  0.158
2008 Ruan YC, Wang Z, Du JY, Zuo WL, Guo JH, Zhang J, Wu ZL, Wong HY, Chung YW, Chan HC, Zhou WL. Regulation of smooth muscle contractility by the epithelium in rat vas deferens: role of ATP-induced release of PGE2. The Journal of Physiology. 586: 4843-57. PMID 18755753 DOI: 10.1113/jphysiol.2008.154096  0.157
2024 Chan JM, Chang YC, Chan HC, Chan HC, Chang WC, Wang LF, Tsai TH, Chen YJ, Huang WC. FK228 suppress the growth of human malignant pleural mesothelioma tumor independent to epithelioid or non-epithelioid histology. Molecular Medicine (Cambridge, Mass.). 30: 73. PMID 38822233 DOI: 10.1186/s10020-024-00835-6  0.157
1994 Huang SJ, Chan HC, Wong PY. Adrenaline-regulated Cl- transport in cultured single rat epididymal cells measured by an entrapped Cl-(-)sensitive fluorophore. The Journal of Physiology. 474: 183-91. PMID 8006808 DOI: 10.1113/jphysiol.1994.sp020012  0.155
1997 Chan HC, Liu CQ, Fong SK, Law SH, Leung PS, Leung PY, Fu WO, Cheng Chew SB, Wong PYD. Electrogenic ion transport in the mouse endometrium: Functional aspects of the cultured epithelium Biochimica Et Biophysica Acta - Molecular Cell Research. 1356: 140-148. PMID 9150272 DOI: 10.1016/S0167-4889(96)00171-1  0.154
2000 Leung PS, Wong TP, Lam SY, Chan HC, Wong PY. Testicular hormonal regulation of the renin-angiotensin system in the rat epididymis. Life Sciences. 66: 1317-24. PMID 10755467 DOI: 10.1016/S0024-3205(00)00439-2  0.154
2014 Chan HC, Sun X. SLC26 anion exchangers in uterine epithelial cells and spermatozoa: clues from the past and hints to the future. Cell Biology International. 38: 1-7. PMID 24115633 DOI: 10.1002/cbin.10183  0.154
2016 Li C, Luo X, Zhao S, Siu GK, Liang Y, Chan HC, Satoh A, Yu SS. COPI-TRAPPII activates Rab18 and regulates its lipid droplet association. The Embo Journal. PMID 28003315 DOI: 10.15252/embj.201694866  0.152
2015 Hsu TC, Chiu CC, Chang SC, Chan HC, Shi YF, Chen TY, Tzang BS. Human parvovirus B19 VP1u Protein as inflammatory mediators induces liver injury in Naïve Mice. Virulence. 0. PMID 26632342 DOI: 10.1080/21505594.2015.1122165  0.151
2012 Peng X, Wu Z, Yu L, Li J, Xu W, Chan HC, Zhang Y, Hu L. Overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) is associated with human cervical cancer malignancy, progression and prognosis. Gynecologic Oncology. 125: 470-6. PMID 22366595 DOI: 10.1016/j.ygyno.2012.02.015  0.151
2023 Fnaiche A, Chan HC, Paquin A, González Suárez N, Vu V, Li F, Allali-Hassani A, Cao MA, Szewczyk MM, Bolotokova A, Allemand F, Gelin M, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, et al. Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. Acs Medicinal Chemistry Letters. 14: 1746-1753. PMID 38116405 DOI: 10.1021/acsmedchemlett.3c00386  0.151
2012 Jiang X, Zhang JT, Chan HC. Ion channels/transporters as epigenetic regulators? -a microRNA perspective. Science China. Life Sciences. 55: 753-60. PMID 23015123 DOI: 10.1007/s11427-012-4369-9  0.15
2006 Ho LS, Tsang LL, Chung YW, Chan HC. Establishment of a mouse primary co-culture of endometrial epithelial cells and peripheral blood leukocytes: effect on epithelial barrier function and leukocyte survival. Cell Biology International. 30: 977-82. PMID 17011218 DOI: 10.1016/j.cellbi.2006.07.004  0.15
2018 Sun X, Guo JH, Zhang D, Chen JJ, Lin WY, Huang Y, Chen H, Huang WQ, Liu Y, Tsang LL, Yu MK, Chung YW, Jiang X, Huang H, Chan HC, et al. Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. Embo Molecular Medicine. PMID 30154237 DOI: 10.15252/emmm.201808868  0.149
2008 Liu B, Xie JX, Tsang LL, Rowlands DK, Ho LS, Gou YL, Chung YW, Chan HC. Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity. Cell Biology International. 32: 86-92. PMID 17920944 DOI: 10.1016/j.cellbi.2007.08.016  0.148
2015 Dong ZW, Chen J, Ruan YC, Zhou T, Chen Y, Chen Y, Tsang LL, Chan HC, Peng YZ. CFTR-regulated MAPK/NF-κB signaling in pulmonary inflammation in thermal inhalation injury. Scientific Reports. 5: 15946. PMID 26515683 DOI: 10.1038/srep15946  0.148
2015 Wang F, Pan J, Liu Y, Meng Q, Lv P, Qu F, Ding GL, Klausen C, Leung PC, Chan HC, Yao W, Zhou CY, Shi B, Zhang J, Sheng J, et al. Alternative splicing of the androgen receptor in polycystic ovary syndrome. Proceedings of the National Academy of Sciences of the United States of America. 112: 4743-8. PMID 25825716 DOI: 10.1073/pnas.1418216112  0.147
1997 Chan HC, Fong SK, So SC, Chung YW, Wong PY. Stimulation of anion secretion by beta-adrenoceptors in the mouse endometrial epithelium. The Journal of Physiology. 501: 517-25. PMID 9218212  0.146
2010 Da Dong J, Wang YR, Jiang XH, Zhou W, Chan HC. CFTR is aberrantly expressed in the glandular epithelium of endometroisis Cell Biology International. 34: S9-S9. DOI: 10.1042/cbi034s009b  0.145
2003 Ajonuma L, Tsang L, Lam S, Ho L, Chan H. Expression and immunolocalization of CFTR and ENaC subunits in rat female upper reproductive tract Fertility and Sterility. 79: 10. DOI: 10.1016/S0015-0282(03)00093-1  0.145
1994 Chan HC, Fu WO, Chung YW, Huang SJ, Chan PS, Wong PY. Swelling-induced anion and cation conductances in human epididymal cells. The Journal of Physiology. 449-60. PMID 7525948 DOI: 10.1113/jphysiol.1994.sp020264  0.145
2003 Xing Y, He Q, Zhu JX, Chan HC. Basolateral membrane mechanisms involved in ligustrazine-stimulated anion secretion in rat distal colon. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 55: 653-7. PMID 14695481  0.144
1995 Chan HC, Fu WO, Chung YW, Zhou TS, Wong PY. Adrenergic receptors on cultured rat epididymal cells: regulation of Cl- conductances. Biology of Reproduction. 51: 1040-5. PMID 7849180 DOI: 10.1095/biolreprod51.5.1040  0.144
2017 Zhao S, Li CM, Luo XM, Siu GK, Gan WJ, Zhang L, Wu WK, Chan HC, Yu S. Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles. Scientific Reports. 7: 43207. PMID 28240221 DOI: 10.1038/srep43207  0.144
2014 Sun X, Ruan YC, Guo J, Chen H, Tsang LL, Zhang X, Jiang X, Chan HC. Regulation of miR-101/miR-199a-3p by the epithelial sodium channel during embryo implantation: involvement of CREB phosphorylation. Reproduction (Cambridge, England). 148: 559-68. PMID 25187622 DOI: 10.1530/REP-14-0386  0.142
2001 Li P, Chan HC, He B, So SC, Chung YW, Shang Q, Zhang YD, Zhang YL. An antimicrobial peptide gene found in the male reproductive system of rats. Science (New York, N.Y.). 291: 1783-5. PMID 11230693 DOI: 10.1126/science.1056545  0.141
2012 Rowlands DK, Cui YG, So SC, Tsang LL, Chung YW, Chan HC. Bak Foong Pills induce an analgesic effect by inhibiting nociception via the somatostatin pathway in mice. Cell Biology International. 36: 63-9. PMID 21980955 DOI: 10.1042/CBI20110015  0.141
1997 Chan HC, Wong PY. Paracrine/autocrine regulation of anion secretion in the epididymis: role of angiotensin II. Biological Signals. 5: 309-16. PMID 9116797 DOI: 10.1159/000109204  0.141
2016 Lin YT, Yu YM, Chang WC, Chiang SY, Chan HC, Lee MF. Ursolic acid plays a protective role in obesity-induced cardiovascular diseases. Canadian Journal of Physiology and Pharmacology. 1-7. PMID 26991492 DOI: 10.1139/cjpp-2015-0407  0.14
2008 Yu L, Tang H, Chan HC. Effects of kanamycin sulfate on the expression of prestin in cochlear outer hair cells in mice ototoxicitial models Cell Biology International. 32: S47-S47. DOI: 10.1016/j.cellbi.2008.01.201  0.139
2006 Chan HC, Zhang YL. Epididymial defensins and sperm maturation. Andrologia. 37: 200-1. PMID 16336246 DOI: 10.1111/j.1439-0272.2005.00687.x  0.139
2019 Guo M, Zhou C, Xu G, Tang L, Ruan Y, Yu Y, Lin X, Wu D, Chen H, Yu P, Jin L, Wang Y, Wu Y, Ullah K, Rahman TU, ... ... Chan HC, et al. An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction. Science China. Life Sciences. PMID 31197761 DOI: 10.1007/s11427-018-9535-9  0.138
2005 Ajonuma LC, Ng EH, Chan LN, Chow PH, Kung LS, Cheung AN, Ho LS, Briton-Jones C, Lok IH, Haines CJ, Chan HC. Ultrastructural characterization of whole hydrosalpinx from infertile Chinese women. Cell Biology International. 29: 849-56. PMID 16105743 DOI: 10.1016/J.Cellbi.2005.05.012  0.138
2009 Liu CH, Huang LJ, Kuo SC, Lee TH, Tsai KJ, Chan HC. 4-Fluoro-N-butylphenylacetamide (H6) inhibits cell growth via cell-cycle arrest and apoptosis in human cervical cancer cells. Bioorganic & Medicinal Chemistry. 17: 42-8. PMID 19056280 DOI: 10.1016/j.bmc.2008.11.028  0.137
1996 Zhao W, Leung PY, Cheng Chew SB, Chan HC, Wong PYD. Localization and distribution of angiotensin II in the rat epididymis Journal of Endocrinology. 149: 217-222. PMID 8708532  0.136
2010 Liu Y, Jiang X, Yu MK, Dong J, Zhang X, Tsang LL, Chung YW, Li T, Chan HC. Switching from bone marrow-derived neurons to epithelial cells through dedifferentiation and translineage redifferentiation. Cell Biology International. 34: 1075-83. PMID 20939829 DOI: 10.1042/CBI20100516  0.135
2009 Yu YM, Lin CH, Chan HC, Tsai HD. Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells. European Journal of Nutrition. 48: 101-6. PMID 19142568 DOI: 10.1007/s00394-008-0768-x  0.135
2006 Zhu JX, Zhang GH, Yang N, Connie Wong HY, Chung YW, Chan HC. Involvement of intracellular and extracellular Ca2+ in tetramethylpyrazine-induced colonic anion secretion. Cell Biology International. 30: 547-52. PMID 16679037 DOI: 10.1016/j.cellbi.2006.03.003  0.135
2001 Jiang JL, Yu MK, Chen ZN, Chan HC. cGMP-regulated store-operated calcium entry in human hepatoma cells. Cell Biology International. 25: 993-5. PMID 11589615 DOI: 10.1006/cbir.2001.0751  0.134
2021 Yuan C, Huang WQ, Guo JH, Liu XY, Yang JZ, Chen JJ, Wu Y, Ruan YC, Liu JY, Cui YG, Diao FY, Chan HC. Involvement of Kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 166242. PMID 34389474 DOI: 10.1016/j.bbadis.2021.166242  0.134
2012 Hu JC, Chan HC, Simmer SG, Seymen F, Richardson AS, Hu Y, Milkovich RN, Estrella NM, Yildirim M, Bayram M, Chen CF, Simmer JP. Amelogenesis imperfecta in two families with defined AMELX deletions in ARHGAP6. Plos One. 7: e52052. PMID 23251683 DOI: 10.1371/journal.pone.0052052  0.133
2003 Chan HC, Kuo SC, Liu SC, Liu CH, Hsu SL. 4-Fluoro-N-butylphenylacetamide: a synthetic phenylacetate derivative that upregulates Bcl-X(S), activates caspase cascade and induces apoptosis in human squamous lung cancer CH27 cells. Cancer Letters. 186: 211-21. PMID 12213291 DOI: 10.1016/s0304-3835(02)00352-x  0.132
2019 Huang B, Wang B, Yuk-Wai Lee W, Pong U K, Leung KT, Li X, Liu Z, Chen R, Lin JC, Tsang LL, Liu B, Ruan YC, Chan HC, Li G, Jiang X. KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization. Iscience. 21: 375-390. PMID 31704649 DOI: 10.1016/J.Isci.2019.10.041  0.132
2011 Siu KY, Yu MK, Wu X, Zong M, Roth MG, Chan HC, Yu S. The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1. Plos One. 6: e18458. PMID 21483700 DOI: 10.1371/Journal.Pone.0018458  0.132
1997 Leung PS, Chan HC, Fu LXM, Wong PYD. Localization of angiotensin II receptor subtypes AT1 and AT2 in the pancreas of rodents. Journal of Endocrinology. 153: 269-274. PMID 9166116 DOI: 10.1677/Joe.0.1530269  0.132
2009 Chiu K, Chan HC, Yeung SC, Yuen WH, Zee SY, Chang RC, So KF. Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model. Journal of Ocular Biology, Diseases, and Informatics. 2: 47-56. PMID 19672466 DOI: 10.1007/s12177-009-9023-9  0.129
2009 Chiu K, Chan HC, Yeung SC, Yuen WH, Zee SY, Chang RC, So KF. Erratum: Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model. Journal of Ocular Biology, Diseases, and Informatics. 2: 127-136. PMID 20046845 DOI: 10.1007/s12177-009-9035-5  0.128
2008 Xie C, Wang XF, Qi XJ, Lu LL, Chan HC. Effect of Huoxiang-zhengqi liquid on HCO(3)(-) secretion by intact porcine distal airway epithelium. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 60: 90-6. PMID 18288363  0.128
2010 He G, Xu W, Diao R, Chan HC, Liu X, Qie M. The possible role of ENaC in pathogenesis of preeclampsia and the underlying mechanism Cell Biology International. 34: S9-S9. DOI: 10.1042/cbi034s009c  0.127
1997 Chan HC, Zhou TS, Fu WO, Wang WP, Shi YL, Wong PY. Cation and anion channels in rat and human spermatozoa. Biochimica Et Biophysica Acta. 1323: 117-29. PMID 9030218  0.127
2004 Chen J, Tsang LL, Ho LS, Rowlands DK, Gao JY, Ng CP, Chung YW, Chan HC. Modulation of human enteric epithelial barrier and ion transport function by Peyer's patch lymphocytes. World Journal of Gastroenterology. 10: 1594-9. PMID 15162532  0.127
2015 Ma L, Ma R, Wang Y, Zhu X, Zhang J, Chan HC, Chen X, Zhang W, Chiu SK, Zhu G. Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action. Chemical Communications (Cambridge, England). 51: 6301-4. PMID 25644651 DOI: 10.1039/C4Cc10409A  0.127
2021 Zhang XL, Zhao X, Wu Y, Huang WQ, Chen JJ, Hu P, Liu W, Chen YW, Hao J, Xie RR, Chan HC, Ruan YC, Chen H, Guo J. Angiotensin(1-7) activates MAS-1 and upregulates CFTR to promote insulin secretion in pancreatic β-cells: the association with type 2 diabetes. Endocrine Connections. PMID 34825893 DOI: 10.1530/EC-21-0357  0.127
2007 Chan HC. From epithelial cells to body function and disease Sheng Li Xue Bao : [Acta Physiologica Sinica]. 59: 393-396. PMID 23012740  0.126
2002 Ajonuma LC, Ng EH, Briton-Jones C, Lok IH, Haines CJ, Chan HC. Adverse effects of hydrosalpinx epithelial cell culture conditioned medium from Chinese infertile women on sperm motility and acrosome reaction Fertility and Sterility. 78: S153. DOI: 10.1016/S0015-0282(02)03793-7  0.126
2010 Fok KLE, Chung CM, Chan HC. STK31 acts as a cell fate determinant in spermatogonial stem cell Cell Biology International. 34: S37-S37. DOI: 10.1042/cbi034s037a  0.126
2009 Rowlands DK, Cui YG, Wong HY, Gou YL, Chan HC. Traditional Chinese medicine Bak Foong Pills alters uterine quiescence - possible role in alleviation of dysmenorrhoeal symptoms. Cell Biology International. 33: 1207-11. PMID 19341810 DOI: 10.1016/j.cellbi.2009.03.003  0.126
2019 Chen JJ, Xiao ZJ, Meng X, Wang Y, Yu MK, Huang WQ, Sun X, Chen H, Duan YG, Jiang X, Wong MP, Chan HC, Zou F, Ruan YC. MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer. Theranostics. 9: 5049-5064. PMID 31410201 DOI: 10.7150/thno.32097  0.125
2011 Zong M, Wu XG, Chan CW, Choi MY, Chan HC, Tanner JA, Yu S. The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability. Plos One. 6: e23350. PMID 21858081 DOI: 10.1371/Journal.Pone.0023350  0.125
2010 Zhang WK, Wang D, Duan Y, Loy MM, Chan HC, Huang P. Erratum: Mechanosensitive gating of CFTR Nature Cell Biology. 12: 812-812. DOI: 10.1038/ncb0810-812  0.125
2000 Chan HC, Chan LN, Wang XF, Tsang LL, So SC. Regulation of Na+ absorption and Cl- secretion in the endometrium: switching mechanisms Journal of Korean Medical Science. 15. PMID 10981506 DOI: 10.3346/Jkms.2000.15.S.S34  0.125
1997 Ko WH, Chan HC, Wong PY. Anion secretion induced by capacitative Ca2+ entry through apical and basolateral membranes of cultured equine sweat gland epithelium. The Journal of Physiology. 19-29. PMID 8951708 DOI: 10.1113/jphysiol.1996.sp021746  0.125
2017 Lee AS, Chen WY, Chan HC, Chung CH, Peng HY, Chang CM, Su MJ, Chen CH, Chang KC. Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease. Scientific Reports. 7: 40676. PMID 28094801 DOI: 10.1038/srep40676  0.124
2014 Ruan YC, Chen H, Chan HC. Ion channels in the endometrium: regulation of endometrial receptivity and embryo implantation. Human Reproduction Update. 20: 517-29. PMID 24591147 DOI: 10.1093/humupd/dmu006  0.124
2001 Fiscus RR, Leung CPC, Yuen JPS, Chan HC. Quantification of apoptotic DNA fragmentation in a transformed uterine epithelial cell line, HRE-H9, using capillary electrophoresis with laser-induced fluorescence detector (CE-LIF) Cell Biology International. 25: 1007-1011. PMID 11589618 DOI: 10.1006/Cbir.2001.0747  0.124
2012 Lee AS, Wang GJ, Chan HC, Chen FY, Chang CM, Yang CY, Lee YT, Chang KC, Chen CH. Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell-released chemokines. Apoptosis : An International Journal On Programmed Cell Death. 17: 1009-18. PMID 22562555 DOI: 10.1007/s10495-012-0726-1  0.123
2004 Zhu JX, Yang N, Zhang GH, Tsang LL, Gou YL, Wong HY, Chung YW, Chan HC. Improvement of barrier function and stimulation of colonic epithelial anion secretion by Menoease Pills. World Journal of Gastroenterology : Wjg. 10: 2514-8. PMID 15300895  0.122
2023 Yan D, Arakelyan J, Wan T, Raina R, Chan TK, Ahn D, Kushnarev V, Cheung TK, Chan HC, Choi I, Ho PY, Hu F, Kim Y, Lau HL, Law YL, et al. Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties. Acta Pharmaceutica Sinica. B. 14: 421-432. PMID 38261827 DOI: 10.1016/j.apsb.2023.08.025  0.122
2016 Chen CH, Ke LY, Chan HC, Lee AS, Lin KD, Chu CS, Lee MY, Hsiao PJ, Hsu C, Chen CH, Shin SJ. Electronegative Low-Density Lipoprotein Induces Renal Apoptosis and Fibrosis: STRA6 Signaling Involved. Journal of Lipid Research. PMID 27256691 DOI: 10.1194/jlr.M067215  0.122
2025 Ip MWS, Chan HCO. Perceived Security, Confidence in the Police and Subjective Well-Being in Hong Kong: Evidence from the World Values Survey. Behavioral Sciences & the Law. PMID 40437824 DOI: 10.1002/bsl.70001  0.12
2025 Chen KY, Chan HC, Chan CM. Effectiveness and safety of anti-vascular endothelial growth factor therapies for macular edema in retinal vein occlusion: A systematic review and network meta-analysis of randomized controlled trials. Survey of Ophthalmology. PMID 40419166 DOI: 10.1016/j.survophthal.2025.05.008  0.12
2025 Chen KY, Chan HC, Chan CM. How effective and safe are punctal plugs in treating dry eye disease? A systematic review and meta-analysis. Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association. 102438. PMID 40393913 DOI: 10.1016/j.clae.2025.102438  0.12
2025 Chen KY, Chan HC, Chan CM. Which treatment works better for Meibomian Gland Dysfunction: LipiFlow or intense pulsed light? A systematic review and network meta-analysis. Photodiagnosis and Photodynamic Therapy. 53: 104630. PMID 40360035 DOI: 10.1016/j.pdpdt.2025.104630  0.12
1997 Leung PS, Chan HC, Fu LXM, Leung PY, Chew SBC, Wong PYD. Angiotensin II receptors: Localization of type I and type II in rat epididymides of different developmental stages Journal of Membrane Biology. 157: 97-103. PMID 9141362 DOI: 10.1007/S002329900219  0.119
2022 Xu J, Hu P, Zhang X, Chen J, Wang J, Zhang J, Chen Z, Yu MK, Chung YW, Wang Y, Zhang X, Zhang Y, Zheng N, Yao H, Yue J, ... Chan HC, et al. Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/β-catenin signaling. Bioactive Materials. 8: 95-108. PMID 34541389 DOI: 10.1016/j.bioactmat.2021.06.034  0.119
2001 Ajonuma LC, Chan HC, Haines CJ. Hydrosalpinx fluid and in vitro mouse embryo development. The Journal of Obstetrics and Gynaecology Research. 27: 237-40. PMID 11721737 DOI: 10.1111/J.1447-0756.2001.TB01258.X  0.118
2002 Zhu JX, Chan YM, Tsang LL, Chan LN, Zhou Q, Zhou CX, Chan HC. Cellular signaling mechanisms underlying pharmacological action of Bak Foong Pills on gastrointestinal secretion. The Japanese Journal of Physiology. 52: 129-34. PMID 12047811 DOI: 10.2170/jjphysiol.52.129  0.118
2017 Yuan H, Zhang J, Cai Y, Wu S, Yang K, Chan HCS, Huang W, Jin WB, Li Y, Yin Y, Igarashi Y, Yuan S, Zhou J, Tang GL. GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nature Communications. 8: 1485. PMID 29133784 DOI: 10.1038/S41467-017-01508-1  0.118
2003 Ho AL, Gou YL, Rowlands DK, Chung YW, Chan HC. Effects of Bak Foong Pills and Menoease Pills on white blood cell distribution in old age female rats. Biological & Pharmaceutical Bulletin. 26: 1748-53. PMID 14646184 DOI: 10.1248/BPB.26.1748  0.118
2004 Zhu H, Chan HC, Zhou Z, Li J, Zhu H, Yin L, Xu M, Cheng L, Sha J. A Gene Encoding Sialic-Acid-Specific 9-O-Acetylesterase Found in Human Adult Testis. Journal of Biomedicine & Biotechnology. 2004: 130-136. PMID 15292578 DOI: 10.1155/S1110724304307084  0.117
2013 Chen YF, Lin YC, Huang PK, Chan HC, Kuo SC, Lee KH, Huang LJ. Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase. Bioorganic & Medicinal Chemistry. 21: 5064-75. PMID 23867385 DOI: 10.1016/j.bmc.2013.06.046  0.117
2007 Zhang GH, Zhu JX, Xue H, Fan J, Chen X, Tsang LL, Chung YW, Xing Y, Chan HC. Dopamine stimulates Cl(-) absorption coupled with HCO(3)(-) secretion in rat late distal colon. European Journal of Pharmacology. 570: 188-95. PMID 17597606 DOI: 10.1016/j.ejphar.2007.05.038  0.117
2025 Chen KY, Chan HC, Chan CM. Can Stem Cell Therapy Revolutionize Ocular Disease Treatment? A Critical Review of Preclinical and Clinical Advances. Stem Cell Reviews and Reports. PMID 40266467 DOI: 10.1007/s12015-025-10884-x  0.116
2014 Sun T, Guo J, Chen H, Zhang J, Zhang X, Jiang X, Wang F, Xu Z, Huang X, Sha J, Chan HC. Maternal caffeine exposure impairs insulin secretion by pancreatic β-cells and increases the risk of type II diabetes mellitus in offspring. Cell Biology International. 38: 1183-93. PMID 24890676 DOI: 10.1002/Cbin.10321  0.115
2021 Chan HC, Liao YH, Chang HW, Liu CH. The mechanism of anticancer activity of the new synthesized compound - 6,7-Methylenedioxy-4-(2,4-dimethoxyphenyl)quinolin -2(1H)-one(12e) in human ovarian cancer cell lines. Taiwanese Journal of Obstetrics & Gynecology. 60: 266-272. PMID 33678326 DOI: 10.1016/j.tjog.2021.01.002  0.113
2016 Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angewandte Chemie (International Ed. in English). PMID 27460867 DOI: 10.1002/Anie.201605147  0.113
2011 Wang SK, Chan HC, Rajderkar S, Milkovich RN, Uston KA, Kim JW, Simmer JP, Hu JC. Enamel malformations associated with a defined dentin sialophosphoprotein mutation in two families. European Journal of Oral Sciences. 119: 158-67. PMID 22243242 DOI: 10.1111/j.1600-0722.2011.00874.x  0.113
2008 Tang XX, Wong HY, Chan HC. Bicarbonate transport and luminal pH in a CF bronchial cell line and its corrected cell line Cell Biology International. 32: S45-S46. DOI: 10.1016/j.cellbi.2008.01.195  0.112
2013 Han X, Gao J, Shang N, Huang CH, Ko TP, Chen CC, Chan HC, Cheng YS, Zhu Z, Wiegel J, Luo W, Guo RT, Ma Y. Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485. Proteins. 81: 1256-65. PMID 23508990 DOI: 10.1002/prot.24286  0.112
1988 Chan HC, Magin RL, Swartz HM. Delivery of nitroxide spin label to cultured cells by liposomes Magnetic Resonance in Medicine. 8: 160-170. PMID 3210953 DOI: 10.1002/Mrm.1910080206  0.111
2023 Law SH, Chan HC, Ke GM, Kamatam S, Marathe GK, Ponnusamy VK, Ke LY. Untargeted Lipidomic Profiling Reveals Lysophosphatidylcholine and Ceramide as Atherosclerotic Risk Factors in Knockout Mice. International Journal of Molecular Sciences. 24. PMID 37108120 DOI: 10.3390/ijms24086956  0.11
2003 Yang JZ, Ajonuma LC, Tsang LL, Lam SY, Rowlands DK, Chan HC. Differential expression and localization of CFTR and ENaC in mouse endometrium during peri-implantation Fertility and Sterility. 80: 265-266. DOI: 10.1016/S0015-0282(03)01670-4  0.109
2012 Zong M, Satoh A, Yu MK, Siu KY, Ng WY, Chan HC, Tanner JA, Yu S. TRAPPC9 mediates the interaction between p150 and COPII vesicles at the target membrane. Plos One. 7: e29995. PMID 22279557 DOI: 10.1371/Journal.Pone.0029995  0.109
2018 Wang YC, Lee AS, Lu LS, Ke LY, Chen WY, Dong JW, Lu J, Chen Z, Chu CS, Chan HC, Kuzan TY, Tsai MH, Hsu WL, Dixon RAF, Sawamura T, et al. Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. Aging Cell. e12792. PMID 29923368 DOI: 10.1111/acel.12792  0.109
2012 Liu ZG, Yi W, Tao YL, Chan HC, Zeng MS, Xia YF. Aurora-A is an efficient marker for predicting poor prognosis in human nasopharyngeal carcinoma with aggressive local invasion: 208 cases with a 10-year follow-up from a single institution. Oncology Letters. 3: 1237-1244. PMID 22783425 DOI: 10.3892/ol.2012.660  0.108
2020 Griffiths J, Hussain K, Smith HL, Sanders T, Cox KL, Semmrich M, Mårtensson L, Kim J, Inzhelevskaya T, Penfold CA, Tutt AL, Mockridge CI, Chan HC, English V, French RF, et al. Domain binding and isotype dictate the activity of anti-human OX40 antibodies. Journal For Immunotherapy of Cancer. 8. PMID 33428585 DOI: 10.1136/jitc-2020-001557  0.108
2005 Liu B, Xie JX, Rowlands DK, Gou YL, Leung CC, Chung YW, Chan HC. Neuroprotective effects of Bak Foong Pill in 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-induced Parkinson's disease model mice. Biological & Pharmaceutical Bulletin. 27: 1245-50. PMID 15305030 DOI: 10.1248/BPB.27.1245  0.108
2004 Zhou Q, Rowlands DK, Gou YL, Tsang LL, Chung YW, Chan HC. Cardiovascular protective effects of traditional Chinese medicine bak foong pills in spontaneously hypertensive rats. Biological & Pharmaceutical Bulletin. 26: 1095-9. PMID 12913257 DOI: 10.1248/bpb.26.1095  0.107
2024 Hung SC, Chan TF, Chan HC, Wu CY, Chan ML, Jhuang JY, Tan JQ, Mei JB, Law SH, Ponnusamy VK, Chan HC, Ke LY. Lysophosphatidylcholine Impairs the Mitochondria Homeostasis Leading to Trophoblast Dysfunction in Gestational Diabetes Mellitus. Antioxidants (Basel, Switzerland). 13. PMID 39199251 DOI: 10.3390/antiox13081007  0.107
2014 Hu J, Chu Z, Han J, Zhang Q, Zhang D, Dang Y, Ren J, Chan HC, Zhang J, Huang Y. Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes. Cell Death & Disease. 5: e1424. PMID 25232678 DOI: 10.1038/cddis.2014.369  0.107
2016 Siu GK, Zhou F, Yu MK, Zhang L, Wang T, Liang Y, Chen Y, Chan HC, Yu S. Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation. Scientific Reports. 6: 23464. PMID 27010100 DOI: 10.1038/srep23464  0.106
2025 Chen Z, Xu J, Hu P, Du W, Chen J, Zhang X, Zhou W, Gao J, Zhang Y, Dai B, Nie G, Hu J, Zhou L, Xu S, Chan HC, et al. Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis. Journal of Cachexia, Sarcopenia and Muscle. 16: e13708. PMID 39887939 DOI: 10.1002/jcsm.13708  0.106
2001 Chan HC. Epithelial cell biology: An interface with multidisciplines in life sciences. Introducing selected papers from the symposium on Epithelial Cell Biology, Beijing, China, 2000 Cell Biology International. 25: 991-992. DOI: 10.1006/cbir.2001.0748  0.106
2007 Shi Y, Yeung CK, Rowlands DK, Chan HC, Diao M, Sreedhar B. Reduction of bladder capacity alters expression of cholecystokinin B (Cck-B) receptor of the brainstem in rats Journal of Pediatric Urology. 3: S62. DOI: 10.1016/J.Jpurol.2007.01.107  0.106
2019 Chan HCS, Li Y, Dahoun T, Vogel H, Yuan S. New Binding Sites, New Opportunities for GPCR Drug Discovery. Trends in Biochemical Sciences. PMID 30612897 DOI: 10.1016/J.Tibs.2018.11.011  0.106
2004 Liu B, Dong XL, Xie JX, Gou YL, Rowlands DK, Chan HC. Effect of Bak Foong pills on enhancing dopamine release from the amygdala of female rats. Biological & Pharmaceutical Bulletin. 26: 1028-30. PMID 12843633 DOI: 10.1248/BPB.26.1028  0.106
2010 Chang NW, Pei RJ, Tseng HC, Yeh KT, Chan HC, Lee MR, Lin C, Hsieh WT, Kao MC, Tsai MH, Lin CF. Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis. Chemico-Biological Interactions. 183: 231-7. PMID 19840781 DOI: 10.1016/j.cbi.2009.10.005  0.105
2020 Chan HCS, Xu Y, Tan L, Vogel H, Cheng J, Wu D, Yuan S. Enhancing the Signaling of GPCRs via Orthosteric Ions. Acs Central Science. 6: 274-282. PMID 32123746 DOI: 10.1021/acscentsci.9b01247  0.105
2023 Zhu H, Yip HC, Cheung MK, Chan HC, Ng C, Lau EHL, Yeung ZWC, Wong EWY, Leung L, Qu X, Wang D, Cai L, Chan PKS, Chan JYK, Chen Z. Convergent dysbiosis of upper aerodigestive microbiota between patients with esophageal and oral cavity squamous cell carcinoma. International Journal of Cancer. PMID 36752573 DOI: 10.1002/ijc.34460  0.105
2014 Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, et al. Squalene synthase as a target for Chagas disease therapeutics. Plos Pathogens. 10: e1004114. PMID 24789335 DOI: 10.1371/Journal.Ppat.1004114  0.104
2016 Chan HC, Filipek S, Yuan S. The Principles of Ligand Specificity on beta-2-adrenergic receptor. Scientific Reports. 6: 34736. PMID 27703221 DOI: 10.1038/srep34736  0.104
2007 Zhang JP, Liang WY, Luo ZH, Yang ZC, Chan HC, Huang YS. Involvement of p38 MAP kinase in burn-induced degradation of membrane phospholipids and upregulation of cPLA2 in cardiac myocytes. Shock (Augusta, Ga.). 28: 86-93. PMID 17483741 DOI: 10.1097/SHK.0b013e31802f9d9a  0.103
2012 Wang SK, Chan HC, Makovey I, Simmer JP, Hu JC. Novel PAX9 and COL1A2 missense mutations causing tooth agenesis and OI/DGI without skeletal abnormalities. Plos One. 7: e51533. PMID 23227268 DOI: 10.1371/journal.pone.0051533  0.102
2015 Ma R, Wang Y, Yan L, Ma L, Wang Z, Chan HC, Chiu SK, Chen X, Zhu G. Efficient co-delivery of a Pt(IV) prodrug and a p53 activator to enhance the anticancer activity of cisplatin. Chemical Communications (Cambridge, England). 51: 7859-62. PMID 25854514 DOI: 10.1039/C4Cc09879J  0.1
2022 Wang X, Yuan S, Chan HCS. Translocation Mechanism of Allosteric Sodium Ions in β-Adrenoceptor. Journal of Chemical Information and Modeling. PMID 35695388 DOI: 10.1021/acs.jcim.2c00170  0.099
2014 Feng X, Hu Y, Zheng Y, Zhu W, Li K, Huang CH, Ko TP, Ren F, Chan HC, Nega M, Bogue S, López D, Kolter R, Götz F, Guo RT, et al. Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production. Chemistry & Biology. 21: 1557-63. PMID 25308276 DOI: 10.1016/J.Chembiol.2014.08.018  0.099
2008 Xie C, Chan HC. The age-dependent expression of CFTR and carbonic anhydrase II in rat prostate Cell Biology International. 32: S46-S46. DOI: 10.1016/j.cellbi.2008.01.198  0.097
2003 Zhao WC, Zhu JX, Tang N, Gou YL, Rowlands DK, Chung YW, Xing Y, Chan HC. Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion. World Journal of Gastroenterology : Wjg. 9: 2505-8. PMID 14606085  0.096
2016 Zhang JT, Weng Z, Tsang KS, Tsang LL, Chan HC, Jiang XH. Correction: MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells. Plos One. 11: e0154068. PMID 27077735 DOI: 10.1371/Journal.Pone.0154068  0.095
2010 Chen JJ, Jiang XH, Chan HC. Involvement of CFTR in photodynamic therapy-mediated apoptosis Cell Biology International. 34: S44-S44. DOI: 10.1042/cbi034s044a  0.095
2021 Chan HC, Wang SC, Lin CH, Lin YZ, Li RN, Yen JH. A novel CD209 polymorphism is associated with rheumatoid arthritis patients in Taiwan. Journal of Clinical Laboratory Analysis. e23751. PMID 33792986 DOI: 10.1002/jcla.23751  0.095
1986 Magin RL, Wright SM, Niesman MR, Chan HC, Swartz HM. Liposome delivery of NMR contrast agents for improved tissue imaging Magnetic Resonance in Medicine. 3: 440-447. PMID 3724423 DOI: 10.1002/Mrm.1910030309  0.094
2008 He Q, Yan Wong CH, Tsang LL, Chan HC. Cyclic changes in uterine bicarbonate secretion and the underlying mechanisms Cell Biology International. 32: S43-S43. DOI: 10.1016/j.cellbi.2008.01.184  0.094
2020 Chen WY, Chen YF, Chan HC, Chung CH, Peng HY, Ho YC, Chen CH, Chang KC, Tang CH, Lee AS. Role of apolipoprotein E in electronegative low-density lipoprotein-induced mitochondrial dysfunction in cardiomyocytes. Metabolism: Clinical and Experimental. 154227. PMID 32275974 DOI: 10.1016/j.metabol.2020.154227  0.094
2007 Zhu JX, Chan HC. Effects of Bak Foong Pill and its active components on body functions and gastrointestinal epithelial ion transport. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 59: 477-86. PMID 17700967  0.094
2022 Simmer JP, Zhang H, Moon SJH, Donnelly LA, Lee YL, Seymen F, Koruyucu M, Chan HC, Lee KY, Wu S, Hsiang CL, Tsai ATP, Slayton RL, Morrow M, Wang SK, et al. The Modified Shields Classification and 12 Families with Defined Mutations. Genes. 13. PMID 35627243 DOI: 10.3390/genes13050858  0.094
2007 Chan HC, Chang RC, Koon-Ching Ip A, Chiu K, Yuen WH, Zee SY, So KF. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Experimental Neurology. 203: 269-73. PMID 17045262 DOI: 10.1016/j.expneurol.2006.05.031  0.093
2008 Xie C, Lu LL, Zang CB, Wang XF, Chan HC. Huoxiang-Zhengqi liquid stimulates camp-independent HCO3- secretion in porcine distal airway epithelium Cell Biology International. 32: S46-S46. DOI: 10.1016/j.cellbi.2008.01.196  0.093
2003 Sha J, Zhou Z, Li J, Yin L, Yang H, Hu G, Luo M, Chan HC, Zhou K. Identification of testis development and spermatogenesis-related genes in human and mouse testes using cDNA arrays. Molecular Human Reproduction. 8: 511-7. PMID 12029067 DOI: 10.1093/molehr/8.6.511  0.093
2004 Ning Y, Zhu JX, Chan HC. Regulation of ion transport by 5-hydroxytryptamine in rat colon. Clinical and Experimental Pharmacology & Physiology. 31: 424-8. PMID 15236628 DOI: 10.1111/j.1440-1681.2004.04015.x  0.092
2016 Ke LY, Chan HC, Chen CC, Lu X, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH, Chen CH. Enhanced Sphingomyelinase Activity Contributes to the Apoptotic Capacity of Electronegative Low-Density Lipoprotein. Journal of Medicinal Chemistry. PMID 26766134 DOI: 10.1021/acs.jmedchem.5b01534  0.092
2011 Yang LL, Wu JB, Liu ZG, U L, Zeng MS, Yan SS, Chan HC, Xia YF. Preparation of anti-NYD-SP8 rabbit polyclonal antibody and its application in the analysis of NYD-SP8 expression in nasopharyngeal carcinoma cell lines and clinical tissues. Tumori. 97: 655-9. PMID 22158499 DOI: 10.1700/989.10727  0.092
2019 Chan HCO, Sheridan L. Who Are the Stalking Victims? Exploring the Victimization Experiences and Psychosocial Characteristics of Young Male and Female Adults in Hong Kong. Journal of Interpersonal Violence. 886260519889938. PMID 31789116 DOI: 10.1177/0886260519889938  0.09
2013 Chan HC, Ke LY, Chu CS, Lee AS, Shen MY, Cruz MA, Hsu JF, Cheng KH, Chan HC, Lu J, Lai WT, Sawamura T, Sheu SH, Yen JH, Chen CH. Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. 122: 3632-41. PMID 24030386 DOI: 10.1182/blood-2013-05-504639  0.089
2013 Guo G, Sun X, Chen C, Wu S, Huang P, Li Z, Dean M, Huang Y, Jia W, Zhou Q, Tang A, Yang Z, Li X, Song P, Zhao X, ... ... Chan HC, et al. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nature Genetics. 45: 1459-63. PMID 24121792 DOI: 10.1038/Ng.2798  0.089
2011 Heide KM, Roe-Sepowitz D, Solomon EP, Chan HC. Male and female juveniles arrested for murder: a comprehensive analysis of U.S. data by offender gender. International Journal of Offender Therapy and Comparative Criminology. 56: 356-84. PMID 21507995 DOI: 10.1177/0306624X11406418  0.088
2023 Lui KS, Ye Z, Chan HC, Tanaka Y, Cheung AKL. Anti-PD1 does not improve pyroptosis induced by γδ T cells but promotes tumor regression in a pleural mesothelioma mouse model. Frontiers in Immunology. 14: 1282710. PMID 38077396 DOI: 10.3389/fimmu.2023.1282710  0.086
2019 Tseng CC, Lin YZ, Lin CH, Li RN, Yen CY, Chan HC, Tsai WC, Ou TT, Wu CC, Sung WY, Yen JH. Next-Generation Sequencing Profiles of the Methylome and Transcriptome in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis. Journal of Clinical Medicine. 8. PMID 31443559 DOI: 10.3390/jcm8091284  0.086
2021 Chan HCO. Risky Sexual Behavior of Young Adults in Hong Kong: An Exploratory Study of Psychosocial Risk Factors. Frontiers in Psychology. 12: 658179. PMID 33828516 DOI: 10.3389/fpsyg.2021.658179  0.085
2013 Fang F, Zhang Q, Chan JY, Razali O, Azlan H, Chan HC, Sanderson JE, Xie JM, Yu CM. Early pacing-induced systolic dyssynchrony is a strong predictor of left ventricular adverse remodeling: analysis from the Pacing to Avoid Cardiac Enlargement (PACE) trial. International Journal of Cardiology. 168: 723-8. PMID 22944596 DOI: 10.1016/J.Ijcard.2012.08.005  0.085
2010 Liu Y, Sun TT, Jiang XH, Li TY, Chan HC. Mesenchymal stem cells enhances the viability of primary culture of rat hippocampal neurons under oxidative stress Cell Biology International. 34: S40-S40. DOI: 10.1042/cbi034s040a  0.085
2008 Liu Y, Li TY, Zhang XH, Chung YW, Chan HC. Behavioral improvement induced by bone marrow mesenchymal stem cells in neonatal rats after hypoxic-ischemic brain damage Cell Biology International. 32: S23-S23. DOI: 10.1016/j.cellbi.2008.01.101  0.085
2020 Ke LY, Chan HC, Chen CC, Chang CF, Lu PL, Chu CS, Lai WT, Shin SJ, Liu FT, Chen CH. Increased APOE glycosylation plays a key role in the atherogenicity of L5 low-density lipoprotein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32501643 DOI: 10.1096/Fj.202000659R  0.084
2004 Li TY, Shu C, Wong CH, Lo PS, Zhu H, Lau MC, Chan MY, Tsang LL, Gou YL, Chung YW, Chan HC. Plasticity of rat bone marrow-derived 5-hydroxytryptamine-sensitive neurons: dedifferentiation and redifferentiation. Cell Biology International. 28: 801-7. PMID 15563402 DOI: 10.1016/J.Cellbi.2004.07.010  0.084
1993 Dedman JR, Kaetzel MA, Chan HC, Nelson DJ, Jamieson GA. Selection of targeted biological modifiers from a bacteriophage library of random peptides. The identification of novel calmodulin regulatory peptides. The Journal of Biological Chemistry. 268: 23025-30. PMID 8226817  0.084
2020 Chan HCO, Sheridan L, Adjorlolo S. Stalking and Intrusive Behaviors in Ghana: Perceptions and Victimization Experiences. International Journal of Environmental Research and Public Health. 17. PMID 32235368 DOI: 10.3390/ijerph17072298  0.083
2009 Sheppard DN, Zhu J, Chan HC. Unravelling the complexity of Cl- channels: how long is a piece of string? The Journal of Physiology. 587: 2113-4. PMID 19443850 DOI: 10.1113/jphysiol.2009.172825  0.083
2006 Chen J, Ng CP, Rowlands DK, Xu PH, Gao JY, Chung YW, Chan HC. Interaction between enteric epithelial cells and Peyer's patch lymphocytes in response to Shigella lipopolysaccharide: effect on nitric oxide and IL-6 release. World Journal of Gastroenterology : Wjg. 12: 3895-900. PMID 16804978  0.083
2015 Chen YF, Lin YC, Chen JP, Chan HC, Hsu MH, Lin HY, Kuo SC, Huang LJ. Synthesis and biological evaluation of novel 3,9-substituted β-carboline derivatives as anticancer agents. Bioorganic & Medicinal Chemistry Letters. PMID 26235951 DOI: 10.1016/j.bmcl.2015.07.058  0.082
2011 Ruan YC, Zhou W, Chan HC. Regulation of smooth muscle contraction by the epithelium: role of prostaglandins. Physiology (Bethesda, Md.). 26: 156-70. PMID 21670162 DOI: 10.1152/physiol.00036.2010  0.082
2008 Zhang JP, Gu H, Zhang XH, Gou YL, Xu WM, Burd A, Huang L, Huang YS, Chan HC. Delayed wound healing in CD-9 null mice Cell Biology International. 32: S47-S47. DOI: 10.1016/j.cellbi.2008.01.202  0.081
1990 Chan HC, Sun K, Magin RL, Swartz HM. Potential of albumin labeled with nitroxides as a contrast agent for magnetic resonance imaging and spectroscopy Bioconjugate Chemistry. 1: 32-36. PMID 1965624 DOI: 10.1021/Bc00001A004  0.081
2015 Chakraborty R, Mukkamalla SK, Gutzmore G, Chan HC. A case of Hodgkin's lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD. Journal of Blood Medicine. 6: 93-7. PMID 25848330 DOI: 10.2147/JBM.S67664  0.08
2010 Xie C, Tang X, Xu W, Diao R, Cai Z, Chan HC. A host defense mechanism involving CFTR-mediated bicarbonate secretion in bacterial prostatitis. Plos One. 5: e15255. PMID 21151921 DOI: 10.1371/journal.pone.0015255  0.08
2010 Chan HC, Ke LY, Chang LL, Liu CC, Hung YH, Lin CH, Li RN, Tsai WC, Liu HW, Yen JH. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. Lupus. 19: 696-702. PMID 20064913 DOI: 10.1177/0961203309357437  0.08
2020 Chew NJ, Nguyen EV, Su SP, Novy K, Chan HC, Nguyen LK, Luu J, Simpson KJ, Lee RS, Daly RJ. FGFR3 signaling and function in triple negative breast cancer. Cell Communication and Signaling : Ccs. 18: 13. PMID 31987043 DOI: 10.1186/s12964-019-0486-4  0.08
2015 Shen MY, Chen FY, Hsu JF, Fu RH, Chang CM, Chang CT, Liu CH, Wu JR, Lee AS, Chan HC, Sheu JR, Lin SZ, Shyu WC, Sawamura T, Chang KC, et al. Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet activation and aggregation. Blood. PMID 26679863 DOI: 10.1182/blood-2015-05-646117  0.08
2011 Chan HC, Estrella NM, Milkovich RN, Kim JW, Simmer JP, Hu JC. Target gene analyses of 39 amelogenesis imperfecta kindreds. European Journal of Oral Sciences. 119: 311-23. PMID 22243262 DOI: 10.1111/j.1600-0722.2011.00857.x  0.079
1998 Yu ZH, Chan HC. Gossypol as a male antifertility agent--why studies should have been continued. International Journal of Andrology. 21: 2-7. PMID 9639145 DOI: 10.1046/j.1365-2605.1998.00091.x  0.079
2010 Chan HC, Ke LY, Liu CC, Chang LL, Tsai WC, Liu HW, Yen JH. Increased expression of suppressor of cytokine signaling 1 mRNA in patients with rheumatoid arthritis. The Kaohsiung Journal of Medical Sciences. 26: 290-8. PMID 20538233 DOI: 10.1016/S1607-551X(10)70042-5  0.079
2021 Chan HCO. Who Are the Stalkers in Hong Kong? Examining Stalking Perpetration Behaviors and Motives of Young Adults. International Journal of Environmental Research and Public Health. 18. PMID 34886525 DOI: 10.3390/ijerph182312798  0.078
2017 Lee AS, Xi Y, Lai CH, Chen WY, Peng HY, Chan HC, Chen CH, Chang KC. Human electronegative low-density lipoprotein modulates cardiac repolarization via LOX-1-mediated alteration of sarcolemmal ion channels. Scientific Reports. 7: 10889. PMID 28883612 DOI: 10.1038/s41598-017-10503-x  0.078
2013 Luo W, Huang JW, Huang CH, Huang TY, Chan HC, Liu JR, Guo RT, Chen CC. Preliminary X-ray diffraction analysis of thermostable β-1,4-mannanase from Aspergillus niger BK01. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 1100-2. PMID 24100557 DOI: 10.1107/S1744309113023348  0.077
2014 Zou XW, Liu YC, Hsu NS, Huang CJ, Lyu SY, Chan HC, Chang CY, Yeh HW, Lin KH, Wu CJ, Tsai MD, Li TL. Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase. Acta Crystallographica. Section D, Biological Crystallography. 70: 1549-60. PMID 24914966 DOI: 10.1107/S1399004714005239  0.076
2019 Lin HL, Lin SH, Shen KP, Chan HC, Tseng YH, Yen HW, Law SH, Ke LY. Efficiency comparison of PGBR extract and γ-oryzanol in antioxidative stress and anti-inflammatory properties against metabolic syndrome. Journal of Food Biochemistry. e13129. PMID 31846084 DOI: 10.1111/jfbc.13129  0.076
2020 Chan HC, Ke LY, Lu HT, Weng SF, Chan HC, Law SH, Lin IL, Chang CF, Lu YH, Chen CH, Chu CS. An Increased Plasma Level of ApoCIII-Rich Electronegative High-Density Lipoprotein May Contribute to Cognitive Impairment in Alzheimer's Disease. Biomedicines. 8. PMID 33256187 DOI: 10.3390/biomedicines8120542  0.075
2024 Chan HC, Chattopadhyay A, Lu TP. Cross-population enhancement of PrediXcan predictions with a gnomAD-based east Asian reference framework. Briefings in Bioinformatics. 25. PMID 39441246 DOI: 10.1093/bib/bbae549  0.075
2025 Chen KY, Chan HC, Chan CM. Is a thermal pulsation system (LipiFlow) effective as a standalone treatment for meibomian gland dysfunction and dry eye? A systematic review and meta-analysis. Therapeutic Advances in Ophthalmology. 17: 25158414251338775. PMID 40352434 DOI: 10.1177/25158414251338775  0.075
2023 Law SH, Ke CC, Chu CS, Liu SH, Weng MC, Ke LY, Chan HC. Trimodality optical imaging for tracking subendothelial retention of electronegative low-density lipoprotein in vivo. International Journal of Biological Macromolecules. 126069. PMID 37536403 DOI: 10.1016/j.ijbiomac.2023.126069  0.075
2010 Zhang WK, Wang D, Duan Y, Loy MM, Chan HC, Huang P. Erratum: Mechanosensitive gating of CFTR Nature Cell Biology. 12: 727-727. DOI: 10.1038/Ncb0710-727  0.075
2025 Chattopadhyay A, Wu YT, Chan HC, Kang YT, Chiang YC, Chiang CJ, Lee WC, Lu TP. Predicting Survival Outcomes for Patients with Ovarian Cancer Using National Cancer Registry Data from Taiwan: A Retrospective Cohort Study. Women's Health Reports (New Rochelle, N.Y.). 6: 90-101. PMID 39882147 DOI: 10.1089/whr.2024.0166  0.075
2017 Chan HCO, Heide KM, Beauregard E. Male and Female Single-Victim Sexual Homicide Offenders: Distinguishing the Types of Weapons Used in Killing Their Victims. Sexual Abuse : a Journal of Research and Treatment. 1079063217724765. PMID 28832274 DOI: 10.1177/1079063217724765  0.074
2015 Chan HC, Jiang D, Fung HH. Role conflict and satisfaction in the work-family context: Age differences in the moderating effect of role commitment. Psych Journal. 4: 20-7. PMID 26263527 DOI: 10.1002/Pchj.89  0.074
2020 Shin SJ, Chen CH, Kuo WC, Chan HC, Chan HC, Lin KD, Ke LY. Disruption of Retinoid Homeostasis Induces RBP4 Overproduction in Diabetes: O-GlcNAcylation Involved. Metabolism: Clinical and Experimental. 154403. PMID 33065162 DOI: 10.1016/j.metabol.2020.154403  0.074
2021 Lei L, Chan HC, Lu TP, Cheng SH. Risk evaluation of early-stage hormone receptor-positive and human epidermal growth factor receptor 2-negative breast cancer patients: a population-based study from Taiwan. Breast Cancer Research and Treatment. PMID 34282518 DOI: 10.1007/s10549-021-06330-4  0.073
2006 Yu CM, Zhang Q, Yip GW, Chan YS, Lee PW, Wu LW, Lam YY, Kum LC, Chan HC, Chan S, Fung JW. Are left ventricular diastolic function and diastolic asynchrony important determinants of response to cardiac resynchronization therapy? The American Journal of Cardiology. 98: 1083-7. PMID 17027576 DOI: 10.1016/J.Amjcard.2006.05.028  0.073
2016 Chan HC, Ng SC. Emerging biologics in inflammatory bowel disease. Journal of Gastroenterology. PMID 27832357 DOI: 10.1007/s00535-016-1283-0  0.073
2013 Chan HC, Frei AM, Myers WC. Female sexual homicide offenders: an analysis of the offender racial profiles in offending process. Forensic Science International. 233: 265-72. PMID 24314528 DOI: 10.1016/J.Forsciint.2013.09.011  0.071
2017 Chan HCO, Sheridan L. Is This Stalking? Perceptions of Stalking Behavior Among Young Male and Female Adults in Hong Kong and Mainland China. Journal of Interpersonal Violence. 886260517711180. PMID 29294767 DOI: 10.1177/0886260517711180  0.071
2007 Fung JW, Chan JY, Yip GW, Chan HC, Chan WW, Zhang Q, Yu CM. Effect of left ventricular endocardial activation pattern on echocardiographic and clinical response to cardiac resynchronization therapy. Heart (British Cardiac Society). 93: 432-7. PMID 17237127 DOI: 10.1136/Hrt.2007.115295  0.07
2014 Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, et al. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. Journal of the American Chemical Society. 136: 2892-6. PMID 24475925 DOI: 10.1021/Ja413127V  0.07
1996 Chen KP, Chen FS, Yu PY, Chan HC. [Clinical experience of laryngeal mask airway combined with continuous intravenous propofol infusion during general anesthesia]. Acta Anaesthesiologica Sinica. 34: 209-12. PMID 9084549  0.07
2003 Gou YL, Ho AL, Rowlands DK, Chung YW, Chan HC. Effects of Bak Foong Pill on blood coagulation and platelet aggregation. Biological & Pharmaceutical Bulletin. 26: 241-6. PMID 12576687 DOI: 10.1248/BPB.26.241  0.069
2007 Li YS, Ho JY, Huang CC, Lyu SY, Lee CY, Huang YT, Wu CJ, Chan HC, Huang CJ, Hsu NS, Tsai MD, Li TL. A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation. Journal of the American Chemical Society. 129: 13384-5. PMID 17935335 DOI: 10.1021/Ja075748X  0.069
2021 Chan HC, Chattopadhyay A, Chuang EY, Lu TP. Development of a Gene-Based Prediction Model for Recurrence of Colorectal Cancer Using an Ensemble Learning Algorithm. Frontiers in Oncology. 11: 631056. PMID 33692961 DOI: 10.3389/fonc.2021.631056  0.068
2025 Chen KY, Chan HC, Chan CM. Is Botulinum toxin A effective in treating dry eye disease? A systematic review and meta-analysis. Eye (London, England). PMID 40204900 DOI: 10.1038/s41433-025-03790-6  0.067
2024 Leung CCD, Chan HCC, Chan MC, Chan YH, Ho MY, Chen CH, Ngai CM, Yeung YC. Kikuchi-Fujimoto disease following SARS-CoV-2 infection: A rare disease with increased incidence during the COVID-19 pandemic? Respirology Case Reports. 12: e01414. PMID 38903947 DOI: 10.1002/rcr2.1414  0.067
2014 Yang Y, Ko TP, Liu L, Li J, Huang CH, Chan HC, Ren F, Jia D, Wang AH, Guo RT, Chen J, Du G. Structural insights into enzymatic degradation of oxidized polyvinyl alcohol. Chembiochem : a European Journal of Chemical Biology. 15: 1882-6. PMID 25044912 DOI: 10.1002/Cbic.201402166  0.066
2021 Fang TJ, Lin CH, Lin YZ, Chiu MH, Li RN, Chan HC, Yeh YT, Yen JH. Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility. Journal of the Formosan Medical Association = Taiwan Yi Zhi. PMID 34732304 DOI: 10.1016/j.jfma.2021.10.008  0.066
2012 Tiong WN, Fong AY, Sim EU, Chan HC, Ong TK, Chang BC, Sim KH. Increased serum levels of interleukin-6 and von Willenbrand Factor in early phase of acute coronary syndrome in a young and multiethnic Malaysian population. Heart Asia. 4: 146-50. PMID 27326052 DOI: 10.1136/heartasia-2012-010131  0.066
2021 Lu TP, Wu CH, Chang CC, Chan HC, Chattopadhyay A, Lee WC, Chiang CJ, Lee HY, Tien YW. Distinct Survival Outcomes in Subgroups of Stage III Pancreatic Cancer Patients: Taiwan Cancer Registry and Surveillance, Epidemiology and End Results registry. Annals of Surgical Oncology. PMID 34775547 DOI: 10.1245/s10434-021-11030-w  0.066
2021 Huang YX, Chao YY, Lin YH, Liou JR, Chan HC, Chen YL. Determination of 13--Retinoic Acid and Its Metabolites in Plasma by Micellar Electrokinetic Chromatography Using Cyclodextrin-Assisted Sweeping for Sample Preconcentration. Molecules (Basel, Switzerland). 26. PMID 34641409 DOI: 10.3390/molecules26195865  0.064
2008 Xu JR, Zhao WC, Tian YM, Chan HC. Effect of pressure on ion transport across the colonic epithelium in rat with experimental aganglionosis Cell Biology International. 32: S46-S47. DOI: 10.1016/j.cellbi.2008.01.199  0.064
2012 Myers WC, Chan HC. Juvenile homosexual homicide. Behavioral Sciences & the Law. 30: 90-102. PMID 22447462 DOI: 10.1002/bsl.2000  0.064
2009 Chen CH, Chan HC, Chu YT, Ho HY, Chen PY, Lee TH, Lee CK. Antioxidant activity of some plant extracts towards xanthine oxidase, lipoxygenase and tyrosinase. Molecules (Basel, Switzerland). 14: 2947-58. PMID 19701137 DOI: 10.3390/molecules14082947  0.064
2012 Huang CH, Sun Y, Ko TP, Chen CC, Zheng Y, Chan HC, Pang X, Wiegel J, Shao W, Guo RT. The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485. The Biochemical Journal. 448: 401-7. PMID 22992047 DOI: 10.1042/BJ20121359  0.064
2018 Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Exploring a new ligand binding site of G protein-coupled receptors. Chemical Science. 9: 6480-6489. PMID 30310578 DOI: 10.1039/C8Sc01680A  0.063
2024 Chen C, Lo CYZ, Ho MJC, Ng Y, Chan HCY, Wu WHK, Ong MEH, Siddiqui FJ. Global Sex Disparities in Bystander Cardiopulmonary Resuscitation After Out-of-Hospital Cardiac Arrest: A Scoping Review. Journal of the American Heart Association. e035794. PMID 39248262 DOI: 10.1161/JAHA.124.035794  0.063
2011 Chan JY, Fang F, Zhang Q, Fung JW, Razali O, Azlan H, Lam KH, Chan HC, Yu CM. Biventricular pacing is superior to right ventricular pacing in bradycardia patients with preserved systolic function: 2-year results of the PACE trial. European Heart Journal. 32: 2533-40. PMID 21875860 DOI: 10.1093/Eurheartj/Ehr336  0.063
2020 Lin MY, Chan HC, Chi H, Chiu SC, Nora-Krukle Z, Rasa-Dzelzkaleja S, Vilmane A, Murovska M, Lin JH, Liu HF. Genetic Diversity and Phylogenetic Analysis of Human Bocavirus 2 in Pediatric Patients with Acute Gastroenteritis in Taiwan. International Journal of Environmental Research and Public Health. 17. PMID 32046345 DOI: 10.3390/ijerph17031086  0.061
2008 Tang KH, Niebuhr M, Tung CS, Chan HC, Chou CC, Tsai MD. Mismatched dNTP incorporation by DNA polymerase beta does not proceed via globally different conformational pathways. Nucleic Acids Research. 36: 2948-57. PMID 18385153 DOI: 10.1093/Nar/Gkn138  0.061
2009 Yu CM, Chan JY, Zhang Q, Omar R, Yip GW, Hussin A, Fang F, Lam KH, Chan HC, Fung JW. Biventricular pacing in patients with bradycardia and normal ejection fraction. The New England Journal of Medicine. 361: 2123-34. PMID 19915220 DOI: 10.1056/Nejmoa0907555  0.061
1989 Chan HC, Glockner JF, Swartz HM. Oximetry in cells and tissues using a nitroxide-liposome system Bba - Molecular Cell Research. 1014: 141-144. PMID 2554973 DOI: 10.1016/0167-4889(89)90026-8  0.061
2019 Chen CH, Ke LY, Chan HC, Chu CS, Lee AS, Lin KD, Lee MY, Hsiao PJ, Chen CH, Shin SJ. Electronegative low-density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta via disruption of STRA6 cascade. Journal of Diabetes Investigation. PMID 31597015 DOI: 10.1111/jdi.13158  0.06
2017 Shi HY, Chan FK, Higashimori A, Kyaw M, Ching JY, Chan HC, Chan JC, Chan AW, Lam KL, Tang RS, Wu JC, Sung JJ, Ng SC. A prospective study on second-generation colon capsule endoscopy to detect mucosal lesions and disease activity in ulcerative colitis (with video). Gastrointestinal Endoscopy. PMID 28713062 DOI: 10.1016/j.gie.2017.07.007  0.06
2015 Chen CC, Huang JW, Zhao P, Ko TP, Huang CH, Chan HC, Huang Z, Liu W, Cheng YS, Liu JR, Guo RT. Structural analyses and yeast production of the β-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum. Enzyme and Microbial Technology. 71: 1-7. PMID 25765303 DOI: 10.1016/j.enzmictec.2015.01.002  0.06
2014 Mariano TY, Chan HC, Myers WC. Toward a more holistic understanding of filicide: a multidisciplinary analysis of 32 years of U.S. arrest data. Forensic Science International. 236: 46-53. PMID 24529774 DOI: 10.1016/j.forsciint.2013.12.019  0.06
2024 Leung CCD, Chan YH, Ho MY, Chan MC, Chen CH, Ngai CM, Chan HCC, Yeung YC. A Single Lung Abscess Caused by Panton-Valentine Leukocidin-Producing Methicillin-Resistant Staphylococcus aureus. Cureus. 16: e61845. PMID 38978918 DOI: 10.7759/cureus.61845  0.059
2010 Chan HC, Mai L, Oikonomopoulou A, Chan HL, Richardson AS, Wang SK, Simmer JP, Hu JC. Altered enamelin phosphorylation site causes amelogenesis imperfecta. Journal of Dental Research. 89: 695-9. PMID 20439930 DOI: 10.1177/0022034510365662  0.059
2020 Chan HC, Bonnie Chan HC, Liang CJ, Lee HC, Su H, Lee AS, Shiea J, Tsai WC, Ou TT, Wu CC, Chu CS, Dixon RA, Ke LY, Yen JH, Chen CH. Role of Low-density Lipoprotein in Early Vascular Aging Associated With Systemic Lupus Erythematosus. Arthritis & Rheumatology (Hoboken, N.J.). PMID 31994323 DOI: 10.1002/art.41213  0.059
2001 Ng FH, Cheung TC, Chow KC, Wong SY, Ng WF, Chan HC, Chau WK, Chang CM. Repeated intestinal perforation caused by an incomplete form of Behçet's syndrome. Journal of Gastroenterology and Hepatology. 16: 935-9. PMID 11555112 DOI: 10.1046/j.1440-1746.2001.02423.x  0.059
1979 Chan HC. The role of the doctor in the management of hypertension The Nursing Journal of Singapore. 19: 30-31. PMID 258318  0.059
2020 Ke LY, Law SH, Mishra VK, Parveen F, Chan HC, Lu YH, Chu CS. Molecular and Cellular Mechanisms of Electronegative Lipoproteins in Cardiovascular Diseases. Biomedicines. 8. PMID 33260304 DOI: 10.3390/biomedicines8120550  0.059
2017 Theunissen C, Métayer B, Lecomte M, Henry N, Chan HC, Compain G, Gérard P, Bachmann C, Mokhtari N, Marrot J, Martin-Mingot A, Thibaudeau S, Evano G. Cationic polycyclization of ynamides: building up molecular complexity. Organic & Biomolecular Chemistry. PMID 28485455 DOI: 10.1039/c7ob00850c  0.059
2022 Chan HCO. Is This Stalking? Perceptions and Victimization Experiences of Stalking and Intrusive Behaviors in Hong Kong, Mainland China, and Ghana. International Journal of Environmental Research and Public Health. 19. PMID 35682273 DOI: 10.3390/ijerph19116689  0.059
2014 Xu J, Ren F, Huang CH, Zheng Y, Zhen J, Sun H, Ko TP, He M, Chen CC, Chan HC, Guo RT, Song H, Ma Y. Functional and structural studies of pullulanase from Anoxybacillus sp. LM18-11. Proteins. 82: 1685-93. PMID 24375572 DOI: 10.1002/prot.24498  0.059
2005 Ko GTC, Tsang CC, Chan HCK. Stabilization and regression of albuminuria in Chinese patients with type 2 diabetes: A one-year randomized study of valsartan versus enalapril Advances in Therapy. 22: 155-162. PMID 16020405  0.058
2022 Lai CKC, Cheung MK, Lui GCY, Ling L, Chan JYK, Ng RWY, Chan HC, Yeung ACM, Ho WCS, Boon SS, Chan PKS, Chen Z. Limited Impact of SARS-CoV-2 on the Human Naso-Oropharyngeal Microbiota in Hospitalized Patients. Microbiology Spectrum. e0219622. PMID 36350127 DOI: 10.1128/spectrum.02196-22  0.058
2019 Yang FY, Zhang XH, Tsang LL, Chan HC, Jiang XH. Dedifferentiation-reprogrammed mesenchymal stem cells for neonates with hypoxic-ischaemic brain injury. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi. 25: 12-16. PMID 31416979  0.058
2011 Liu YC, Li YS, Lyu SY, Hsu LJ, Chen YH, Huang YT, Chan HC, Huang CJ, Chen GH, Chou CC, Tsai MD, Li TL. Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds. Nature Chemical Biology. 7: 304-9. PMID 21478878 DOI: 10.1038/Nchembio.556  0.057
1978 Feng PH, Chan HC, Jacob E, Chio LF, Oon CJ, Sinniah R. Tubular functions in lupus nephropathy Singapore glomerulonephritis study group. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet. 170-6. PMID 627789  0.057
2018 Chan HCO, Beauregard E. Prostitute homicides: A 37-year exploratory study of the offender, victim, and offense characteristics. Forensic Science International. 294: 196-203. PMID 30544084 DOI: 10.1016/J.Forsciint.2018.11.022  0.057
2013 Jiang T, Chan HC, Huang CH, Ko TP, Huang TY, Liu JR, Guo RT. Substrate binding to a GH131 β-glucanase catalytic domain from Podospora anserina. Biochemical and Biophysical Research Communications. 438: 193-7. PMID 23880343 DOI: 10.1016/j.bbrc.2013.07.051  0.057
2023 An Q, Li N, Zhao Z, Wang N, Wang X, Yang X, Yang D, Zhang L, Lu Y, Du G, Chan HCS. Two Novel Metformin Carboxylate Salts and the Accidental Discovery of Two 1,3,5-Triazine Antihyperglycemic Agent. Acs Omega. 8: 48028-48041. PMID 38144133 DOI: 10.1021/acsomega.3c06721  0.057
2025 Chen KY, Lee HK, Chan HC, Chan CM. Is Multiwavelength Photobiomodulation Effective and Safe for Age-Related Macular Degeneration? A Systematic Review and Meta-Analysis. Ophthalmology and Therapy. PMID 40089957 DOI: 10.1007/s40123-025-01119-w  0.057
1995 Chen KP, Chan HC, Huang SJ. Foley catheter used as bronchial blocker for one lung ventilation in a patient with tracheostomy--a case report. Acta Anaesthesiologica Sinica. 33: 41-4. PMID 7788198  0.056
2023 Ling L, Lai CKC, Lui G, Yeung ACM, Chan HC, Cheuk CHS, Cheung AN, Chang LC, Chiu LCS, Zhang JZ, Wong WT, Hui DSC, Wong CK, Chan PKS, Chen Z. Characterization of upper airway microbiome across severity of COVID-19 during hospitalization and treatment. Frontiers in Cellular and Infection Microbiology. 13: 1205401. PMID 37469595 DOI: 10.3389/fcimb.2023.1205401  0.056
2014 Wang S, Nie Y, Yan X, Ko TP, Huang CH, Chan HC, Guo RT, Xiao R. Crystallization and preliminary X-ray diffraction analysis of (R)-carbonyl reductase from Candida parapsilosis. Acta Crystallographica. Section F, Structural Biology Communications. 70: 800-2. PMID 24915097 DOI: 10.1107/S2053230X1400908X  0.056
2015 Chan HC, Lo TW, Zhong LY, Chui WH. Criminal recidivism of incarcerated male nonviolent offenders in Hong Kong. International Journal of Offender Therapy and Comparative Criminology. 59: 121-42. PMID 24052598 DOI: 10.1177/0306624X13502965  0.056
2005 Chan HC, Adnan WA, Jaalam K, Abdullah MR, Abdullah J. Which mild head injured patients should have follow-up after discharge from an accident and emergency ward? A study in a university hospital setting in Kelantan, Malaysia. The Southeast Asian Journal of Tropical Medicine and Public Health. 36: 982-93. PMID 16295557  0.056
2017 Myers WC, Chan HC, Mariano TY, Safarik ME, Geberth VJ. Sexual Homicide by Older Male Offenders. Journal of Forensic Sciences. PMID 28120457 DOI: 10.1111/1556-4029.13388  0.056
2024 Chan HCO, DeLisi M, Edgemon TG. Classifying Female Sexual Homicide Offenders: A Latent Class Analysis of Murder Arrestees in the U.S. Behavioral Sciences & the Law. PMID 39645660 DOI: 10.1002/bsl.2709  0.054
2024 Leung CCD, Yu ELM, Chan YH, Ho MY, Kwok CT, Chan HCC, Yeung YC. Chronic Obstructive Pulmonary Disease and the Omicron Variant of COVID-19 Prognosis: A Retrospective Cohort Study. Cureus. 16: e65713. PMID 39211713 DOI: 10.7759/cureus.65713  0.054
2024 Lim O, Chua WY, Wong A, Ling RR, Chan HC, Quek SC, Wu S, Somani J. The environmental impact and sustainability of infection control practices: a systematic scoping review. Antimicrobial Resistance and Infection Control. 13: 156. PMID 39719628 DOI: 10.1186/s13756-024-01507-0  0.054
2021 Chan HCO. Sex worker homicides and sexual homicides: A comparative study of offender, victim, and offense characteristics. Behavioral Sciences & the Law. PMID 34145624 DOI: 10.1002/bsl.2528  0.054
2017 Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. Designing Safer Analgesics via μ-Opioid Receptor Pathways. Trends in Pharmacological Sciences. PMID 28935293 DOI: 10.1016/J.Tips.2017.08.004  0.054
2003 Ko GT, Chan HC. Restoration of nocturnal dip in blood pressure is associated with improvement in left ventricular ejection fraction. A 1-year clinical study comparing the effects of amlodipine and nifedipine retard on ambulatory blood pressure and left ventricular systolic function in Chinese hypertensive type 2 diabetic patients. International Journal of Cardiology. 89: 159-66. PMID 12767538 DOI: 10.1016/s0167-5273(02)00450-3  0.054
2010 Guo J, Chen H, Zhang X, Chan HC. Caffeine effect on the calcium response evoked by NMDA and GABA on primary cultured hypothalamus neurons. Cell Biology International. 34: S17-S17. DOI: 10.1042/cbi034s017b  0.053
2005 Fung JW, Yu CM, Chan JY, Chan HC, Yip GW, Zhang Q, Sanderson JE. Effects of cardiac resynchronization therapy on incidence of atrial fibrillation in patients with poor left ventricular systolic function. The American Journal of Cardiology. 96: 728-31. PMID 16125504 DOI: 10.1016/J.Amjcard.2005.04.053  0.052
2024 Chan MC, Leung CCD, Chan YH, Ho MY, Chen CH, Ngai CM, Chan HCC, Yeung YC. A Rare Case of Tracheal Schwannoma Successfully Treated With Endoscopic Resection and Cryoablation Under Rigid Bronchoscopy. Case Reports in Pulmonology. 2024: 2961560. PMID 39444951 DOI: 10.1155/2024/2961560  0.051
2020 Liu K, Zou R, Cui W, Li M, Wang X, Dong J, Li H, Li H, Wang P, Shao X, Su W, Chan HCS, Li H, Yuan S. Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2. Acs Pharmacology & Translational Science. 3: 1361-1370. PMID 34778724 DOI: 10.1021/acsptsci.0c00163  0.051
2008 Yan SS, Li L, Xia YF, Liu ZG, Chan HC. Expression of NPCM correlates with radiosensitivity and metastasis in nasopharyngeal carcinoma Cell Biology International. 32: S37-S37. DOI: 10.1016/j.cellbi.2008.01.162  0.051
2010 Chan HC, Wu CT, Welch KB, Loesche WJ. Periodontal disease activity measured by the benzoyl-DL-arginine-naphthylamide test is associated with preterm births. Journal of Periodontology. 81: 982-91. PMID 20384462 DOI: 10.1902/Jop.2010.090532  0.051
2015 Adjorlolo S, Chan HC. The Nature of Instrumentality and Expressiveness of Homicide Crime Scene Behaviors: A Review. Trauma, Violence & Abuse. PMID 26206795 DOI: 10.1177/1524838015596528  0.051
1994 Wu KC, Wong TK, Chan HC, Wu YW, Hui YL, Tan PP. Endotracheal lidocaine instillation in pediatric anesthesia. Ma Zui Xue Za Zhi = Anaesthesiologica Sinica. 30: 237-41. PMID 1344238  0.051
2019 Chan HCO. Violent Offending, Nonviolent Offending, and General Delinquency: Exploring the Criminogenic Risk Factors of Hong Kong Male and Female Adolescents. International Journal of Offender Therapy and Comparative Criminology. 306624X19881917. PMID 31602999 DOI: 10.1177/0306624X19881917  0.05
2022 Chan HCO. Perceptions of stalking in Mainland China: Behaviors, motives, and effective coping strategies. Behavioral Sciences & the Law. 40: 640-659. PMID 36076331 DOI: 10.1002/bsl.2591  0.05
2010 Liao CW, Sukati H, D'Lamini P, Chou CM, Liu YH, Huang YC, Chung MH, Mtsetfwa JS, Jonato J, Chiu WT, Chang PW, Du WY, Chan HC, Chu TB, Cheng HC, et al. Seroprevalence of Toxocara canis infection among children in Swaziland, southern Africa. Annals of Tropical Medicine and Parasitology. 104: 73-80. PMID 20149294 DOI: 10.1179/136485910X12607012373795  0.05
2023 Chan HCN, Fei X, Leung ELY, Langston K, Marshall S, van der Meij BS. Post-discharge consequences of protein-energy malnutrition, sarcopenia, and frailty in older adults admitted to rehabilitation: A systematic review. Clinical Nutrition Espen. 54: 382-397. PMID 36963884 DOI: 10.1016/j.clnesp.2023.01.023  0.05
2022 Chen CH, Lo WC, Hu PJ, Chan HC, Shen WC, Wu MS, Wu MY. Efficacy of Osteoporosis Medications for Patients With Chronic Kidney Disease: An Updated Systematic Review and Network Meta-Analysis. Frontiers in Pharmacology. 13: 822178. PMID 35222037 DOI: 10.3389/fphar.2022.822178  0.05
2021 Chan HC, Bueno B, Le Roch A, Gagnon A. Copper-Promoted N-Arylation of the Imidazole Side Chain of Protected Histidine by Using Triarylbismuth Reagents. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34357653 DOI: 10.1002/chem.202102186  0.05
2021 Chan HC, Huang CC, Huang CC, Chattopadhyay A, Yeh KH, Lee WC, Chiang CJ, Lee HY, Cheng SH, Lu TP. Predicting Colon Cancer-Specific Survival for the Asian Population Using National Cancer Registry Data from Taiwan. Annals of Surgical Oncology. PMID 34427821 DOI: 10.1245/s10434-021-10646-2  0.05
2005 Chan JY, Fung JW, Chan HC, Chan WW, Yu CM, Sanderson JE. Prolongation of atrial effective refractory period with biatrial nonexcitatory stimulation. Journal of Cardiovascular Electrophysiology. 16: 853-7. PMID 16101626 DOI: 10.1111/J.1540-8167.2005.40502.X  0.049
2023 Chan HCO, Myers WC. Risky Sexual Behavior, Paraphilic Interest, and Sexual Offending: The Study of a Community Sample of Young Adults in Hong Kong. International Journal of Environmental Research and Public Health. 20. PMID 36901292 DOI: 10.3390/ijerph20054279  0.049
2013 Chui WH, Chan HC. Psychological characteristics of male 14- to 20-year-olds on probation and in a residential home in Hong Kong. Criminal Behaviour and Mental Health : Cbmh. 23: 41-55. PMID 23386575 DOI: 10.1002/cbm.1851  0.049
2010 Yang L, Chung CM, Tao Y, Yi W, Chan HC, Xia Y. NYD-SP8 expression in nasopharyngeal carcinoma and its clinical significance Cell Biology International. 34: S55-S55. DOI: 10.1042/cbi034s055a  0.048
1986 Wong BK, Chan HC, Corcoran GB. Selective effects of N-acetylcysteine stereoisomers on hepatic glutathione and plasma sulfate in mice. Toxicology and Applied Pharmacology. 86: 421-9. PMID 3787634  0.048
2024 Chen KY, Chan HC, Chan CM. Is retinal vein occlusion highly associated with an increased risk of myocardial infarction? A systematic review and meta-analysis. International Journal of Retina and Vitreous. 10: 86. PMID 39533338 DOI: 10.1186/s40942-024-00606-9  0.048
1990 Shyr MH, Wong TK, Chen FS, Chan HC, Tan PP. Low concentration of caudal bupivacaine for postoperative analgesia in elective pediatric surgery. Ma Zui Xue Za Zhi = Anaesthesiologica Sinica. 28: 453-8. PMID 2132804  0.048
2005 Zhang Q, Yu CM, Fung JW, Zhang Y, Chan YS, Chan HC, Yip GW, Sanderson JE. Assessment of the effect of cardiac resynchronization therapy on intraventricular mechanical synchronicity by regional volumetric changes. The American Journal of Cardiology. 95: 126-9. PMID 15619410 DOI: 10.1016/J.Amjcard.2004.08.078  0.048
2017 Sun Z, Wu L, Bocola M, Chan HCS, Lonsdale R, Kong XD, Yuan S, Zhou J, Reetz MT. Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. Journal of the American Chemical Society. PMID 29232125 DOI: 10.1021/Jacs.7B10278  0.047
2017 Adjorlolo S, Chan HCO. Determination of Competency to Stand Trial (Fitness to Plead): An Exploratory Study in Hong Kong. Psychiatry, Psychology, and Law : An Interdisciplinary Journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law. 24: 205-222. PMID 31983949 DOI: 10.1080/13218719.2016.1247417  0.047
2009 Huang YT, Lyu SY, Chuang PH, Hsu NS, Li YS, Chan HC, Huang CJ, Liu YC, Wu CJ, Yang WB, Li TL. In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin. Chembiochem : a European Journal of Chemical Biology. 10: 2480-7. PMID 19731276 DOI: 10.1002/cbic.200900351  0.046
2019 Cheng KC, Lam WC, Chan HC, Ngo CC, Cheung MH, So HS, Lam KM. Emergency attendances and hospitalisations for complications after transrectal ultrasound-guided prostate biopsies: a five-year retrospective multicentre study. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi. 25. PMID 31601774 DOI: 10.12809/hkmj197825  0.046
2006 Chiu WK, Cheung LK, Chan HC, Chow LK. A comparison of post-operative complications following wisdom tooth surgery performed with sterile or clean gloves. International Journal of Oral and Maxillofacial Surgery. 35: 174-9. PMID 16154315 DOI: 10.1016/j.ijom.2005.07.003  0.046
2007 Ko GT, Tsang PC, Wai HP, Kan EC, Chan HC. Rosiglitazone versus bedtime insulin in the treatment of patients with conventional oral antidiabetic drug failure: a 1-year randomized clinical trial. Advances in Therapy. 23: 799-808. PMID 17142216 DOI: 10.1007/BF02850321  0.046
2016 Chan HC, Wong VW, Wong GL, Tang W, Wu JC, Ng SC. Prevalence of hepatitis B and clinical outcomes in inflammatory bowel disease patients in a viral-endemic region. Bmc Gastroenterology. 16: 100. PMID 27549153 DOI: 10.1186/s12876-016-0516-2  0.046
2007 Fung JW, Szeto CC, Chan JY, Zhang Q, Chan HC, Yip GW, Yu CM. Prognostic value of renal function in patients with cardiac resynchronization therapy. International Journal of Cardiology. 122: 10-6. PMID 17174419 DOI: 10.1016/j.ijcard.2006.11.015  0.045
2006 Fung JW, Zhang Q, Yip GW, Chan JY, Chan HC, Yu CM. Effect of cardiac resynchronization therapy in patients with moderate left ventricular systolic dysfunction and wide QRS complex: a prospective study. Journal of Cardiovascular Electrophysiology. 17: 1288-92. PMID 16987381 DOI: 10.1111/j.1540-8167.2006.00612.x  0.044
2023 Wong BPK, Lam RPK, Ip CYT, Chan HC, Zhao L, Lau MCK, Tsang TC, Tsui MSH, Rainer TH. Applying artificial neural network in predicting sepsis mortality in the emergency department based on clinical features and complete blood count parameters. Scientific Reports. 13: 21463. PMID 38052864 DOI: 10.1038/s41598-023-48797-9  0.044
1979 Monster AW, Chan HC, O'Connor D. Long-term trends in human eye blink rate. Biotelemetry and Patient Monitoring. 5: 206-22. PMID 754827  0.044
2014 Wang S, Nie Y, Xu Y, Zhang R, Ko TP, Huang CH, Chan HC, Guo RT, Xiao R. Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase. Chemical Communications (Cambridge, England). 50: 7770-2. PMID 24834985 DOI: 10.1039/C4Cc01752H  0.043
2010 Chao CC, Hsu PC, Jen CF, Chen IH, Wang CH, Chan HC, Tsai PW, Tung KC, Wang CH, Lan CY, Chuang YJ. Zebrafish as a model host for Candida albicans infection. Infection and Immunity. 78: 2512-21. PMID 20308295 DOI: 10.1128/IAI.01293-09  0.043
2015 Li F, Chan HC, Liu S, Jia H, Li H, Hu Y, Wang Z, Huang W. Carbon monoxide poisoning as a cause of death in Wuhan, China: A retrospective six-year epidemiological study (2009-2014). Forensic Science International. 253: 112-118. PMID 26115227 DOI: 10.1016/j.forsciint.2015.06.007  0.043
1994 Yang CH, Yu CC, Seah YS, Chan HC, Tan PP. Effect of intravenous clonidine on prevention of postepidural shivering. Ma Zui Xue Za Zhi = Anaesthesiologica Sinica. 31: 121-6. PMID 7934684  0.042
2013 Ren F, Feng X, Ko TP, Huang CH, Hu Y, Chan HC, Liu YL, Wang K, Chen CC, Pang X, He M, Li Y, Oldfield E, Guo RT. Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus. Chembiochem : a European Journal of Chemical Biology. 14: 195-9. PMID 23322418 DOI: 10.1002/Cbic.201200748  0.042
2019 Chew KS, Liaw SY, Ahmad Zahedi AZ, Wong SSL, Singmamae N, Kaushal DN, Chan HC. Development, validation and translation of cardiopulmonary resuscitation and automated external defibrillator training and placement bilingual questionnaire. Bmc Research Notes. 12: 670. PMID 31639035 DOI: 10.1186/s13104-019-4698-x  0.042
2022 Hou Y, Wang S, Bai B, Chan HCS, Yuan S. Accurate Physical Property Predictions via Deep Learning. Molecules (Basel, Switzerland). 27. PMID 35268770 DOI: 10.3390/molecules27051668  0.042
2008 Fung JW, Yip GW, Zhang Q, Fang F, Chan JY, Li CM, Wu LW, Chan GC, Chan HC, Yu CM. Improvement of left atrial function is associated with lower incidence of atrial fibrillation and mortality after cardiac resynchronization therapy. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 5: 780-6. PMID 18467188 DOI: 10.1016/J.Hrthm.2008.02.043  0.042
2020 Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip HC, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY. Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding. The New England Journal of Medicine. 382: 1299-1308. PMID 32242355 DOI: 10.1056/NEJMoa1912484  0.041
2022 Lee CY, Wu MY, Chan HC, Chen TT, Hsu LY, Wu MS, Cherng YG. The Influence of Diabetes Mellitus on the Risks of End-Stage Kidney Disease and Mortality After Liver Transplantation. Transplant International : Official Journal of the European Society For Organ Transplantation. 36: 10023. PMID 35185375 DOI: 10.3389/ti.2022.10023  0.041
2022 Chan HCO. Trust in the Police during the Pro-Democracy Movement in Hong Kong: Psychosocial Factors of Perceived Procedural and Distributive Justice. International Journal of Environmental Research and Public Health. 19. PMID 35682085 DOI: 10.3390/ijerph19116495  0.041
2025 Chen KY, Chan HC, Chan CM. Is Selective Laser Trabeculoplasty Effective in Reducing Intraocular Pressure for Primary Angle-Closure Glaucoma? A Systematic Review and Meta-Analysis. Current Eye Research. 1-11. PMID 40172081 DOI: 10.1080/02713683.2025.2481306  0.041
1982 Chan SH, Feng PH, Srinivasan N, Wee GB, Chan HC. HLA and systemic lupus erythematosus in Chinese. Human Immunology. 3: 345-50. PMID 7327952 DOI: 10.1016/0198-8859(81)90070-7  0.041
2020 Chu CS, Law SH, Lenzen D, Tan YH, Weng SF, Ito E, Wu JC, Chen CH, Chan HC, Ke LY. Clinical Significance of Electronegative Low-Density Lipoprotein Cholesterol in Atherothrombosis. Biomedicines. 8. PMID 32751498 DOI: 10.3390/biomedicines8080254  0.04
1976 Chan HC, Ruyechan WT, Wetmur JG. In vitro iodination of low complexity nucleic acids without chain scission Biochemistry. 15: 5487-5490. PMID 999822  0.04
1993 Chen KP, Chan HC, Chen FS, Wong CH, Chuah EC, Tan PP. Lumbar extradural morphine and caudal extradural morphine for postoperative analgesia and their adverse effects. Ma Zui Xue Za Zhi = Anaesthesiologica Sinica. 31: 25-30. PMID 7968325  0.04
2005 Yu CM, Zhang Q, Fung JW, Chan HC, Chan YS, Yip GW, Kong SL, Lin H, Zhang Y, Sanderson JE. A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging. Journal of the American College of Cardiology. 45: 677-84. PMID 15734610 DOI: 10.1016/J.Jacc.2004.12.003  0.04
2003 Fung JW, Chan HC, Chan JY, Chan WW, Kum LC, Sanderson JE. Ablation of nonsustained or hemodynamically unstable ventricular arrhythmia originating from the right ventricular outflow tract guided by noncontact mapping. Pacing and Clinical Electrophysiology : Pace. 26: 1699-705. PMID 12877703  0.04
2022 Sun Y, Supriya R, Gao Y, Tao D, Yu S, Wang A, Chan HC, Ou X, Wang J, Baker JS. Hypertension and Associated Risk Factors among Children with Intellectual Disability: A Cross-Sectional Study. Nutrients. 14. PMID 35956301 DOI: 10.3390/nu14153127  0.039
1987 Chan HC, Manry MT, Kondraske GV. Classification of resistance to passive motion using minimum probability of error criterion. Annals of Biomedical Engineering. 15: 579-90. PMID 3688586 DOI: 10.1007/Bf02364250  0.039
2017 Ke LY, Chan HC, Chan HC, Kalu FCU, Lee HC, Lin IL, Jhuo SJ, Lai WT, Tsao CR, Sawamura T, Dixon RA, Chen CH, Chu CS, Shin SJ. Electronegative Low-density Lipoprotein L5 Induces Adipose Tissue Inflammation Associated with Metabolic Syndrome. The Journal of Clinical Endocrinology and Metabolism. PMID 29029093 DOI: 10.1210/jc.2017-01657  0.039
2025 Zhang H, Chan HC, Xu J, Jiang M, Tao X, Zhou H, Song X, Fan X. TOM500: A Multi-Organ Annotated Orbital MRI Dataset for Thyroid Eye Disease. Scientific Data. 12: 60. PMID 39805915 DOI: 10.1038/s41597-025-04427-9  0.039
1989 Chan YF, Huang ST, Chan HC, Tan PP. Intraoperative anaphylactic shock--report of two cases Acta Anaesthesiologica Sinica. 27: 389-393. PMID 2483741  0.038
2023 Chan HC, Lo HH. Effects of the original zentangle method on older adults with depressive symptoms a randomized waitlist-controlled trial. Current Psychology (New Brunswick, N.J.). 1-13. PMID 37359601 DOI: 10.1007/s12144-023-04536-x  0.038
2021 Myers WC, Lee E, Montplaisir R, Lazarou E, Safarik M, Chan HCO, Beauregard E. Revenge filicide: An international perspective through 62 cases. Behavioral Sciences & the Law. PMID 33611814 DOI: 10.1002/bsl.2505  0.038
2018 Shu Y, Chen T, Chan HC, Xie L, Gao Q. Chemoselective Hydrogenation of Cinnamaldehyde on Iron-Oxide Modified Pt/MoO3-y Catalysts. Chemistry, An Asian Journal. PMID 30232843 DOI: 10.1002/asia.201801281  0.038
2018 Chen T, Shi Z, Zhang G, Chan HC, Shu Y, Gao Q, Tang Y. Molybdenum-Incorporated Mesoporous Silica: Surface Engineering toward Enhanced Metal-Support Interactions and Efficient Hydrogenation. Acs Applied Materials & Interfaces. PMID 30456945 DOI: 10.1021/acsami.8b16496  0.037
2010 Tsoi KK, Chan HC, Chiu PW, Pau CY, Lau JY, Sung JJ. Second-look endoscopy with thermal coagulation or injections for peptic ulcer bleeding: a meta-analysis. Journal of Gastroenterology and Hepatology. 25: 8-13. PMID 20136971 DOI: 10.1111/j.1440-1746.2009.06129.x  0.037
2024 Chan HCO. Sexual homicide offenders as repeat and nonrepeat offenders: An empirical study of sexual homicide cases in Mainland China. Behavioral Sciences & the Law. PMID 38555587 DOI: 10.1002/bsl.2657  0.037
2025 Chen KY, Chan HC, Chan CM. Is Thermal Pulsation Therapy Effective for Dry Eyes Before and After Cataract Surgery? A Systematic Review and Meta-Analysis. Clinical Ophthalmology (Auckland, N.Z.). 19: 19-33. PMID 39801566 DOI: 10.2147/OPTH.S498869  0.037
1969 Lee MM, Chu PC, Chan HC. Effects of cold on the skeletal growth of albino rats. The American Journal of Anatomy. 124: 239-49. PMID 5774652 DOI: 10.1002/aja.1001240207  0.037
2025 Wang YJ, Chuang C, Chung CC, Chu PC, Lin WC, Zhang JW, Chueh YL, Yang Z, Huang R, Chang KH, Liu HJ, Liu HL, Sun JY, Chang XY, Chan HC, et al. Epitaxial Antiferroelectric BiOS Films with Superior Photoresponse. Acs Applied Materials & Interfaces. PMID 40148227 DOI: 10.1021/acsami.4c22419  0.036
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