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H.C Chan - Publications

Affiliations: 
The Chinese University of Hong Kong, Hong Kong, Hong Kong 
Area:
Oncology, Cell Biology, General Biology
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Year Citation  Score
2016 Lu YC, Yang J, Fok KL, Ye YH, Jin L, Chen ZY, Zhang XM, Huang HF, Chan HC. Involvement of Cl(-)/HCO3(-) exchanger SLC26A3 and SLC26A6 in preimplantation embryo cleavage. Scientific Reports. 6: 28402. PMID 27346053 DOI: 10.1038/srep28402  0.48
2016 Zhang JT, Weng Z, Tsang KS, Tsang LL, Chan HC, Jiang XH. Correction: MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells. Plos One. 11: e0154068. PMID 27077735 DOI: 10.1371/journal.pone.0154068  0.44
2016 Zhang JT, Weng ZH, Tsang KS, Tsang LL, Chan HC, Jiang XH. MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells. Plos One. 11: e0148062. PMID 26815535 DOI: 10.1371/journal.pone.0148062  0.44
2016 Ke LY, Chan HC, Chen CC, Lu X, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH, Chen CH. Enhanced Sphingomyelinase Activity Contributes to the Apoptotic Capacity of Electronegative Low-Density Lipoprotein. Journal of Medicinal Chemistry. PMID 26766134 DOI: 10.1021/acs.jmedchem.5b01534  0.32
2015 Dong ZW, Chen J, Ruan YC, Zhou T, Chen Y, Chen Y, Tsang LL, Chan HC, Peng YZ. CFTR-regulated MAPK/NF-κB signaling in pulmonary inflammation in thermal inhalation injury. Scientific Reports. 5: 15946. PMID 26515683 DOI: 10.1038/srep15946  0.32
2015 Li F, Chan HC, Liu S, Jia H, Li H, Hu Y, Wang Z, Huang W. Carbon monoxide poisoning as a cause of death in Wuhan, China: A retrospective six-year epidemiological study (2009-2014). Forensic Science International. 253: 112-118. PMID 26115227 DOI: 10.1016/j.forsciint.2015.06.007  0.32
2015 Wang C, Jin A, Huang W, Tsang LL, Cai Z, Zhou X, Chen H, Chan HC. Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis. The Journal of Clinical Endocrinology and Metabolism. 100: E955-63. PMID 25996258 DOI: 10.1210/jc.2015-1431  0.4
2015 Chang KC, Lee AS, Chen WY, Lin YN, Hsu JF, Chan HC, Chang CM, Chang SS, Pan CC, Sawamura T, Chang CT, Su MJ, Chen CH. Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction. Journal of Molecular and Cellular Cardiology. 84: 36-44. PMID 25871829 DOI: 10.1016/j.yjmcc.2015.03.016  0.4
2015 Ma R, Wang Y, Yan L, Ma L, Wang Z, Chan HC, Chiu SK, Chen X, Zhu G. Efficient co-delivery of a Pt(IV) prodrug and a p53 activator to enhance the anticancer activity of cisplatin. Chemical Communications (Cambridge, England). 51: 7859-62. PMID 25854514 DOI: 10.1039/c4cc09879j  0.32
2015 Wang F, Pan J, Liu Y, Meng Q, Lv P, Qu F, Ding GL, Klausen C, Leung PC, Chan HC, Yao W, Zhou CY, Shi B, Zhang J, Sheng J, et al. Alternative splicing of the androgen receptor in polycystic ovary syndrome. Proceedings of the National Academy of Sciences of the United States of America. 112: 4743-8. PMID 25825716 DOI: 10.1073/pnas.1418216112  0.32
2015 Chen CC, Huang JW, Zhao P, Ko TP, Huang CH, Chan HC, Huang Z, Liu W, Cheng YS, Liu JR, Guo RT. Structural analyses and yeast production of the β-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum. Enzyme and Microbial Technology. 71: 1-7. PMID 25765303 DOI: 10.1016/j.enzmictec.2015.01.002  0.36
2015 Li J, Zhang JT, Jiang X, Shi X, Shen J, Feng F, Chen J, Liu G, He P, Jiang J, Tsang LL, Wang Y, Rosell R, Jiang L, He J, ... Chan HC, et al. The cystic fibrosis transmembrane conductance regulator as a biomarker in non-small cell lung cancer. International Journal of Oncology. 46: 2107-15. PMID 25760446 DOI: 10.3892/ijo.2015.2921  0.32
2015 Liu XM, Chan HC, Ding GL, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, Qu F, Liu Y, Lu YC, Adashi EY, Sheng JZ, et al. FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+)/CREB pathway. Aging Cell. 14: 409-20. PMID 25754247 DOI: 10.1111/acel.12331  0.32
2015 Chen H, Guo JH, Zhang XH, Chan HC. Defective CFTR-regulated granulosa cell proliferation in polycystic ovarian syndrome. Reproduction (Cambridge, England). 149: 393-401. PMID 25646509 DOI: 10.1530/REP-14-0368  0.4
2015 Ma L, Ma R, Wang Y, Zhu X, Zhang J, Chan HC, Chen X, Zhang W, Chiu SK, Zhu G. Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action. Chemical Communications (Cambridge, England). 51: 6301-4. PMID 25644651 DOI: 10.1039/c4cc10409a  0.32
2015 Dong J, Jiang X, Zhang X, Liu KS, Zhang J, Chen J, Yu MK, Tsang LL, Chung YW, Wang Y, Zhou WL, Chan HC. Dynamically Regulated CFTR Expression and Its Functional Role in Cutaneous Wound Healing. Journal of Cellular Physiology. 230: 2049-58. PMID 25641604 DOI: 10.1002/jcp.24931  0.32
2015 Xie C, Sun X, Chen J, Ng CF, Lau KM, Cai Z, Jiang X, Chan HC. Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. Journal of Cellular Physiology. 230: 1906-15. PMID 25546515 DOI: 10.1002/jcp.24921  0.32
2014 Feng X, Hu Y, Zheng Y, Zhu W, Li K, Huang CH, Ko TP, Ren F, Chan HC, Nega M, Bogue S, López D, Kolter R, Götz F, Guo RT, et al. Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production. Chemistry & Biology. 21: 1557-63. PMID 25308276 DOI: 10.1016/j.chembiol.2014.08.018  0.36
2014 Hu J, Chu Z, Han J, Zhang Q, Zhang D, Dang Y, Ren J, Chan HC, Zhang J, Huang Y. Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes. Cell Death & Disease. 5: e1424. PMID 25232678 DOI: 10.1038/cddis.2014.369  0.32
2014 Sun X, Ruan YC, Guo J, Chen H, Tsang LL, Zhang X, Jiang X, Chan HC. Regulation of miR-101/miR-199a-3p by the epithelial sodium channel during embryo implantation: involvement of CREB phosphorylation. Reproduction (Cambridge, England). 148: 559-68. PMID 25187622 DOI: 10.1530/REP-14-0386  0.44
2014 Diao R, Fok KL, Chen H, Yu MK, Duan Y, Chung CM, Li Z, Wu H, Li Z, Zhang H, Ji Z, Zhen W, Ng CF, Gui Y, Cai Z, ... Chan HC, et al. Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. Science Translational Medicine. 6: 249ra108. PMID 25122636 DOI: 10.1126/scitranslmed.3009071  0.32
2014 Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC, Breton S. CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway. Journal of Cell Science. 127: 4396-408. PMID 25107366 DOI: 10.1242/jcs.148098  0.48
2014 Yang Y, Ko TP, Liu L, Li J, Huang CH, Chan HC, Ren F, Jia D, Wang AH, Guo RT, Chen J, Du G. Structural insights into enzymatic degradation of oxidized polyvinyl alcohol. Chembiochem : a European Journal of Chemical Biology. 15: 1882-6. PMID 25044912 DOI: 10.1002/cbic.201402166  0.36
2014 Guo JH, Chen H, Ruan YC, Zhang XL, Zhang XH, Fok KL, Tsang LL, Yu MK, Huang WQ, Sun X, Chung YW, Jiang X, Sohma Y, Chan HC. Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature Communications. 5: 4420. PMID 25025956 DOI: 10.1038/ncomms5420  0.32
2014 Wang S, Nie Y, Yan X, Ko TP, Huang CH, Chan HC, Guo RT, Xiao R. Crystallization and preliminary X-ray diffraction analysis of (R)-carbonyl reductase from Candida parapsilosis. Acta Crystallographica. Section F, Structural Biology Communications. 70: 800-2. PMID 24915097 DOI: 10.1107/S2053230X1400908X  0.36
2014 Chan HC, Jiang X, Ruan YC. Emerging role of cystic fibrosis transmembrane conductance regulator as an epigenetic regulator: linking environmental cues to microRNAs. Clinical and Experimental Pharmacology & Physiology. 41: 615-22. PMID 24909068 DOI: 10.1111/1440-1681.12271  0.44
2014 Sun T, Guo J, Chen H, Zhang J, Zhang X, Jiang X, Wang F, Xu Z, Huang X, Sha J, Chan HC. Maternal caffeine exposure impairs insulin secretion by pancreatic β-cells and increases the risk of type II diabetes mellitus in offspring. Cell Biology International. 38: 1183-93. PMID 24890676 DOI: 10.1002/cbin.10321  0.44
2014 Wang S, Nie Y, Xu Y, Zhang R, Ko TP, Huang CH, Chan HC, Guo RT, Xiao R. Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase. Chemical Communications (Cambridge, England). 50: 7770-2. PMID 24834985 DOI: 10.1039/c4cc01752h  0.36
2014 Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, et al. Squalene synthase as a target for Chagas disease therapeutics. Plos Pathogens. 10: e1004114. PMID 24789335 DOI: 10.1371/journal.ppat.1004114  0.36
2014 Lee AS, Chen WY, Chan HC, Hsu JF, Shen MY, Chang CM, Bair H, Su MJ, Chang KC, Chen CH. Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL. Cardiovascular Diabetology. 13: 64. PMID 24666525 DOI: 10.1186/1475-2840-13-64  0.4
2014 Jin A, Chen H, Wang C, Tsang LL, Jiang X, Cai Z, Chan HC, Zhou X. Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells. Fertility and Sterility. 101: 1681-7.e1. PMID 24661733 DOI: 10.1016/j.fertnstert.2014.02.007  0.44
2014 Fok KL, Chen H, Ruan YC, Chan HC. Novel regulators of spermatogenesis. Seminars in Cell & Developmental Biology. 29: 31-42. PMID 24594193 DOI: 10.1016/j.semcdb.2014.02.008  0.48
2014 Ruan YC, Chen H, Chan HC. Ion channels in the endometrium: regulation of endometrial receptivity and embryo implantation. Human Reproduction Update. 20: 517-29. PMID 24591147 DOI: 10.1093/humupd/dmu006  0.4
2014 Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, et al. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. Journal of the American Chemical Society. 136: 2892-6. PMID 24475925 DOI: 10.1021/ja413127v  0.36
2014 Xu J, Ren F, Huang CH, Zheng Y, Zhen J, Sun H, Ko TP, He M, Chen CC, Chan HC, Guo RT, Song H, Ma Y. Functional and structural studies of pullulanase from Anoxybacillus sp. LM18-11. Proteins. 82: 1685-93. PMID 24375572 DOI: 10.1002/prot.24498  0.36
2014 Sun TT, Wang Y, Cheng H, Xiao HZ, Xiang JJ, Zhang JT, Yu SB, Martin TA, Ye L, Tsang LL, Jiang WG, Xiaohua J, Chan HC. Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer. Biochimica Et Biophysica Acta. 1843: 618-28. PMID 24373847 DOI: 10.1016/j.bbamcr.2013.12.013  0.48
2013 Guo G, Sun X, Chen C, Wu S, Huang P, Li Z, Dean M, Huang Y, Jia W, Zhou Q, Tang A, Yang Z, Li X, Song P, Zhao X, ... ... Chan HC, et al. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nature Genetics. 45: 1459-63. PMID 24121792 DOI: 10.1038/ng.2798  0.4
2013 Luo W, Huang JW, Huang CH, Huang TY, Chan HC, Liu JR, Guo RT, Chen CC. Preliminary X-ray diffraction analysis of thermostable β-1,4-mannanase from Aspergillus niger BK01. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 1100-2. PMID 24100557 DOI: 10.1107/S1744309113023348  0.36
2013 Diao R, Fok KL, Zhao L, Chen H, Tang H, Chen J, Zheng A, Zhang X, Gui Y, Chan HC, Cai Z. Decreased expression of cystic fibrosis transmembrane conductance regulator impairs sperm quality in aged men. Reproduction (Cambridge, England). 146: 637-45. PMID 24077955 DOI: 10.1530/REP-13-0146  0.48
2013 Zhang JT, Jiang XH, Xie C, Cheng H, Da Dong J, Wang Y, Fok KL, Zhang XH, Sun TT, Tsang LL, Chen H, Sun XJ, Chung YW, Cai ZM, Jiang WG, ... Chan HC, et al. Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer. Biochimica Et Biophysica Acta. 1833: 2961-9. PMID 23916755 DOI: 10.1016/j.bbamcr.2013.07.021  0.48
2013 Jiang T, Chan HC, Huang CH, Ko TP, Huang TY, Liu JR, Guo RT. Substrate binding to a GH131 β-glucanase catalytic domain from Podospora anserina. Biochemical and Biophysical Research Communications. 438: 193-7. PMID 23880343 DOI: 10.1016/j.bbrc.2013.07.051  0.36
2013 Han X, Gao J, Shang N, Huang CH, Ko TP, Chen CC, Chan HC, Cheng YS, Zhu Z, Wiegel J, Luo W, Guo RT, Ma Y. Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485. Proteins. 81: 1256-65. PMID 23508990 DOI: 10.1002/prot.24286  0.36
2013 Ren F, Feng X, Ko TP, Huang CH, Hu Y, Chan HC, Liu YL, Wang K, Chen CC, Pang X, He M, Li Y, Oldfield E, Guo RT. Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus. Chembiochem : a European Journal of Chemical Biology. 14: 195-9. PMID 23322418 DOI: 10.1002/cbic.201200748  0.36
2013 Chen H, Kui C, Chan HC. Ca(2+) mobilization in cumulus cells: role in oocyte maturation and acrosome reaction. Cell Calcium. 53: 68-75. PMID 23218669 DOI: 10.1016/j.ceca.2012.11.007  0.4
2013 Xie C, Jiang XH, Zhang JT, Sun TT, Dong JD, Sanders AJ, Diao RY, Wang Y, Fok KL, Tsang LL, Yu MK, Zhang XH, Chung YW, Ye L, Zhao MY, ... ... Chan HC, et al. CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. Oncogene. 32: 2282-91, 2291.e1-7. PMID 22797075 DOI: 10.1038/onc.2012.251  0.32
2012 Chan HC, Chen H, Ruan Y, Sun T. Physiology and pathophysiology of the epithelial barrier of the female reproductive tract: role of ion channels. Advances in Experimental Medicine and Biology. 763: 193-217. PMID 23397626  0.4
2012 Zhang XH, Ma ZG, Rowlands DK, Gou YL, Fok KL, Wong HY, Yu MK, Tsang LL, Mu L, Chen L, Yung WH, Chung YW, Zhang BL, Zhao H, Chan HC. Flavonoid Myricetin Modulates GABA(A) Receptor Activity through Activation of Ca(2+) Channels and CaMK-II Pathway. Evidence-Based Complementary and Alternative Medicine : Ecam. 2012: 758097. PMID 23258999 DOI: 10.1155/2012/758097  0.32
2012 Hu JC, Chan HC, Simmer SG, Seymen F, Richardson AS, Hu Y, Milkovich RN, Estrella NM, Yildirim M, Bayram M, Chen CF, Simmer JP. Amelogenesis imperfecta in two families with defined AMELX deletions in ARHGAP6. Plos One. 7: e52052. PMID 23251683 DOI: 10.1371/journal.pone.0052052  0.4
2012 Chen H, Lam Fok K, Jiang X, Chan HC. New insights into germ cell migration and survival/apoptosis in spermatogenesis: Lessons from CD147. Spermatogenesis. 2: 264-272. PMID 23248767 DOI: 10.4161/spmg.22014  0.44
2012 Wang SK, Chan HC, Makovey I, Simmer JP, Hu JC. Novel PAX9 and COL1A2 missense mutations causing tooth agenesis and OI/DGI without skeletal abnormalities. Plos One. 7: e51533. PMID 23227268 DOI: 10.1371/journal.pone.0051533  0.4
2012 Jiang X, Zhang JT, Chan HC. Ion channels/transporters as epigenetic regulators? -a microRNA perspective. Science China. Life Sciences. 55: 753-60. PMID 23015123 DOI: 10.1007/s11427-012-4369-9  0.44
2012 Huang CH, Sun Y, Ko TP, Chen CC, Zheng Y, Chan HC, Pang X, Wiegel J, Shao W, Guo RT. The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485. The Biochemical Journal. 448: 401-7. PMID 22992047 DOI: 10.1042/BJ20121359  0.36
2012 Chen J, Fok KL, Chen H, Zhang XH, Xu WM, Chan HC. Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2. Human Reproduction (Oxford, England). 27: 2585-97. PMID 22777528 DOI: 10.1093/humrep/des254  0.48
2012 Ruan YC, Guo JH, Liu X, Zhang R, Tsang LL, Dong JD, Chen H, Yu MK, Jiang X, Zhang XH, Fok KL, Chung YW, Huang H, Zhou WL, Chan HC. Activation of the epithelial Na+ channel triggers prostaglandin Eâ‚‚ release and production required for embryo implantation. Nature Medicine. 18: 1112-7. PMID 22729284 DOI: 10.1038/nm.2771  0.32
2012 Chen H, Ruan YC, Xu WM, Chen J, Chan HC. Regulation of male fertility by CFTR and implications in male infertility. Human Reproduction Update. 18: 703-13. PMID 22709980 DOI: 10.1093/humupd/dms027  0.4
2012 Lu YC, Chen H, Fok KL, Tsang LL, Yu MK, Zhang XH, Chen J, Jiang X, Chung YW, Ma AC, Leung AY, Huang HF, Chan HC. CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development. Cell Research. 22: 1453-66. PMID 22664907 DOI: 10.1038/cr.2012.88  0.48
2012 Wu W, Song W, Li S, Ouyang S, Fok KL, Diao R, Miao S, Chan HC, Wang L. Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability. Journal of Cell Science. 125: 4219-29. PMID 22641691 DOI: 10.1242/jcs.086553  0.48
2012 Tang XX, Fok KL, Chen H, Chan KS, Tsang LL, Rowlands DK, Zhang XH, Dong JD, Ruan YC, Jiang X, Yu SS, Chung YW, Chan HC. Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing. Journal of Cellular Physiology. 227: 3887-94. PMID 22552906 DOI: 10.1002/jcp.24101  0.48
2012 Chen H, Fok KL, Jiang X, Jiang J, Chen Z, Gui Y, Chan HC, Cai Z. CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia. Human Reproduction (Oxford, England). 27: 1568-76. PMID 22451502 DOI: 10.1093/humrep/des050  0.48
2012 Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, Guo RT. Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes. Angewandte Chemie (International Ed. in English). 51: 4157-60. PMID 22431288 DOI: 10.1002/anie.201108002  0.36
2012 Chan HC, Zhu Y, Hu Y, Ko TP, Huang CH, Ren F, Chen CC, Ma Y, Guo RT, Sun Y. Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars. Protein & Cell. 3: 123-31. PMID 22426981 DOI: 10.1007/s13238-012-2026-5  0.36
2012 Fu J, Wang Y, Fok KL, Yang D, Qiu Y, Chan HC, Koide SS, Miao S, Wang L. Anti-ACTL7a antibodies: a cause of infertility. Fertility and Sterility. 97: 1226-33.e1-8. PMID 22386842 DOI: 10.1016/j.fertnstert.2012.02.023  0.48
2012 Peng X, Wu Z, Yu L, Li J, Xu W, Chan HC, Zhang Y, Hu L. Overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) is associated with human cervical cancer malignancy, progression and prognosis. Gynecologic Oncology. 125: 470-6. PMID 22366595 DOI: 10.1016/j.ygyno.2012.02.015  0.36
2012 Jiang X, Chan HC. Magnetic nanoparticles for treatment of gastric cancer. Journal of Gastroenterology and Hepatology. 27: 191-3. PMID 22260281 DOI: 10.1111/j.1440-1746.2011.07031.x  0.44
2012 Chen H, Guo JH, Lu YC, Ding GL, Yu MK, Tsang LL, Fok KL, Liu XM, Zhang XH, Chung YW, Huang P, Huang H, Chan HC. Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS. The Journal of Clinical Endocrinology and Metabolism. 97: 923-32. PMID 22170719 DOI: 10.1210/jc.2011-1363  0.48
2012 Rowlands DK, Cui YG, So SC, Tsang LL, Chung YW, Chan HC. Bak Foong Pills induce an analgesic effect by inhibiting nociception via the somatostatin pathway in mice. Cell Biology International. 36: 63-9. PMID 21980955 DOI: 10.1042/CBI20110015  0.4
2012 Chen J, Jiang XH, Chen H, Guo JH, Tsang LL, Yu MK, Xu WM, Chan HC. CFTR negatively regulates cyclooxygenase-2-PGE(2) positive feedback loop in inflammation. Journal of Cellular Physiology. 227: 2759-66. PMID 21913191 DOI: 10.1002/jcp.23020  0.4
2011 Chan HC, Estrella NM, Milkovich RN, Kim JW, Simmer JP, Hu JC. Target gene analyses of 39 amelogenesis imperfecta kindreds. European Journal of Oral Sciences. 119: 311-23. PMID 22243262 DOI: 10.1111/j.1600-0722.2011.00857.x  0.4
2011 Wang SK, Chan HC, Rajderkar S, Milkovich RN, Uston KA, Kim JW, Simmer JP, Hu JC. Enamel malformations associated with a defined dentin sialophosphoprotein mutation in two families. European Journal of Oral Sciences. 119: 158-67. PMID 22243242 DOI: 10.1111/j.1600-0722.2011.00874.x  0.4
2011 Liu Y, Jiang X, Zhang X, Chen R, Sun T, Fok KL, Dong J, Tsang LL, Yi S, Ruan Y, Guo J, Yu MK, Tian Y, Chung YW, Yang M, ... ... Chan HC, et al. Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential. Stem Cells (Dayton, Ohio). 29: 2077-89. PMID 22052697 DOI: 10.1002/stem.764  0.48
2011 Xu WM, Chen J, Chen H, Diao RY, Fok KL, Dong JD, Sun TT, Chen WY, Yu MK, Zhang XH, Tsang LL, Lau A, Shi QX, Shi QH, Huang PB, ... Chan HC, et al. Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia. Plos One. 6: e19120. PMID 21625623 DOI: 10.1371/journal.pone.0019120  0.48
2011 Chen H, Fok KL, Yu S, Jiang J, Chen Z, Gui Y, Cai Z, Chan HC. CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Molecular Human Reproduction. 17: 405-14. PMID 21343160 DOI: 10.1093/molehr/gar013  0.48
2010 Ajonuma LC, Fok KL, Ho LS, Chan PK, Chow PH, Tsang LL, Wong CH, Chen J, Li S, Rowlands DK, Chung YW, Chan HC. CFTR is required for cellular entry and internalization of Chlamydia trachomatis. Cell Biology International. 34: 593-600. PMID 20178459 DOI: 10.1042/CBI20090227  0.48
2010 Xu W, Zhang X, Chen W, Fok KL, Rowlands DK, Chui YL, Chan HC. Immunization with Bin1b decreases sperm motility with compromised fertility in rats. Fertility and Sterility. 93: 952-958.e1. PMID 19135192 DOI: 10.1016/j.fertnstert.2008.10.066  0.48
2009 Jin JY, Chen WY, Zhou CX, Chen ZH, Yu-Ying Y, Ni Y, Chan HC, Shi QX. Activation of GABAA receptor/Cl- channel and capacitation in rat spermatozoa: HCO3- and Cl- are essential. Systems Biology in Reproductive Medicine. 55: 97-108. PMID 19462289 DOI: 10.1080/19396360802626648  0.4
2009 Yin L, Chung CM, Huo R, Liu H, Zhou C, Xu W, Zhu H, Zhang J, Shi Q, Wong HY, Chen J, Lu Y, Bi Y, Zhao C, Du Y, ... ... Chan HC, et al. A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction. Cellular and Molecular Life Sciences : Cmls. 66: 900-8. PMID 19153666 DOI: 10.1007/s00018-009-8482-2  0.48
2009 Yin LL, Chung CM, Chen J, Fok KL, Ng CP, Jia RR, Ren X, Zhou J, Zhang T, Zhao XH, Lin M, Zhu H, Zhang XH, Tsang LL, Bi Y, ... ... Chan HC, et al. A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis. Journal of Cellular and Molecular Medicine. 13: 4034-41. PMID 19017363 DOI: 10.1111/j.1582-4934.2008.00576.x  0.48
2009 Chan HC, Ruan YC, He Q, Chen MH, Chen H, Xu WM, Chen WY, Xie C, Zhang XH, Zhou Z. The cystic fibrosis transmembrane conductance regulator in reproductive health and disease. The Journal of Physiology. 587: 2187-95. PMID 19015188 DOI: 10.1113/jphysiol.2008.164970  0.4
2009 Chen WY, Xu WM, Chen ZH, Ni Y, Yuan YY, Zhou SC, Zhou WW, Tsang LL, Chung YW, Höglund P, Chan HC, Shi QX. Cl- is required for HCO3- entry necessary for sperm capacitation in guinea pig: involvement of a Cl-/HCO3- exchanger (SLC26A3) and CFTR. Biology of Reproduction. 80: 115-23. PMID 18784352 DOI: 10.1095/biolreprod.108.068528  0.4
2008 Ajonuma LC, Chan PK, Ng EH, Fok KL, Wong CH, Tsang LL, Tang XX, Ho LS, Lau MC, Chung CM, He Q, Huang HY, Yang DZ, Rowlands DK, Chung YW, ... Chan HC, et al. Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in the pathogenesis of hydrosalpinx induced by Chlamydia trachomatis infection. The Journal of Obstetrics and Gynaecology Research. 34: 923-30. PMID 19012687 DOI: 10.1111/j.1447-0756.2008.00826.x  0.48
2008 Wang Y, Guan X, Fok KL, Li S, Zhang X, Miao S, Zong S, Koide SS, Chan HC, Wang L. A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. Cellular and Molecular Life Sciences : Cmls. 65: 3822-9. PMID 18953687 DOI: 10.1007/s00018-008-8452-0  0.48
2008 Ajonuma LC, He Q, Sheung Chan PK, Yu Ng EH, Fok KL, Yan Wong CH, Tsang LL, Ho LS, Lau MC, Huang HY, Yang DZ, Rowlands DK, Tang XX, Zhang XH, Chung YW, ... Chan HC, et al. Involvement of cystic fibrosis transmembrane conductance regulator in infection-induced edema. Cell Biology International. 32: 801-6. PMID 18462959 DOI: 10.1016/j.cellbi.2008.03.010  0.48
2007 Xu WM, Shi QX, Chen WY, Zhou CX, Ni Y, Rowlands DK, Yi Liu G, Zhu H, Ma ZG, Wang XF, Chen ZH, Zhou SC, Dong HS, Zhang XH, Chung YW, ... ... Chan HC, et al. Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility. Proceedings of the National Academy of Sciences of the United States of America. 104: 9816-21. PMID 17519339 DOI: 10.1073/pnas.0609253104  0.4
2007 Yin X, Ouyang S, Xu W, Zhang X, Fok KL, Wong HY, Zhang J, Qiu X, Miao S, Chan HC, Wang L. YWK-II protein as a novel G(o)-coupled receptor for Müllerian inhibiting substance in cell survival. Journal of Cell Science. 120: 1521-8. PMID 17452623 DOI: 10.1242/jcs.001230  0.48
2006 Shu C, Li TY, Tsang LL, Fok KL, Lo PS, Zhu JX, Ho LS, Chung YW, Chan HC. Differentiation of adult rat bone marrow stem cells into epithelial progenitor cells in culture. Cell Biology International. 30: 823-8. PMID 16877014 DOI: 10.1016/j.cellbi.2006.06.004  0.48
2006 Chan HC, Shi QX, Zhou CX, Wang XF, Xu WM, Chen WY, Chen AJ, Ni Y, Yuan YY. Critical role of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Molecular and Cellular Endocrinology. 250: 106-13. PMID 16414184 DOI: 10.1016/j.mce.2005.12.032  0.4
2005 Yang JZ, Ajonuma LC, Rowlands DK, Tsang LL, Ho LS, Lam SY, Chen WY, Zhou CX, Chung YW, Cho CY, Tse JY, James AE, Chan HC. The role of inducible nitric oxide synthase in gamete interaction and fertilization: a comparative study on knockout mice of three NOS isoforms. Cell Biology International. 29: 785-91. PMID 16087361 DOI: 10.1016/j.cellbi.2005.05.005  0.4
Low-probability matches
2015 Liu YC, Li YS, Lyu SY, Hsu LJ, Chen YH, Huang YT, Chan HC, Huang CJ, Chen GH, Chou CC, Tsai MD, Li TL. Addendum: Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds. Nature Chemical Biology. 11: 361. PMID 25885959 DOI: 10.1038/nchembio0515-361  0.28
2016 Chen CH, Ke LY, Chan HC, Lee AS, Lin KD, Chu CS, Lee MY, Hsiao PJ, Hsu C, Chen CH, Shin SJ. Electronegative Low-Density Lipoprotein Induces Renal Apoptosis and Fibrosis: STRA6 Signaling Involved. Journal of Lipid Research. PMID 27256691 DOI: 10.1194/jlr.M067215  0.24
2016 Siu GK, Zhou F, Yu MK, Zhang L, Wang T, Liang Y, Chen Y, Chan HC, Yu S. Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation. Scientific Reports. 6: 23464. PMID 27010100 DOI: 10.1038/srep23464  0.24
2015 Shen MY, Chen FY, Hsu JF, Fu RH, Chang CM, Chang CT, Liu CH, Wu JR, Lee AS, Chan HC, Sheu JR, Lin SZ, Shyu WC, Sawamura T, Chang KC, et al. Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet activation and aggregation. Blood. PMID 26679863 DOI: 10.1182/blood-2015-05-646117  0.24
2014 Zou XW, Liu YC, Hsu NS, Huang CJ, Lyu SY, Chan HC, Chang CY, Yeh HW, Lin KH, Wu CJ, Tsai MD, Li TL. Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase. Acta Crystallographica. Section D, Biological Crystallography. 70: 1549-60. PMID 24914966 DOI: 10.1107/S1399004714005239  0.24
2013 Chan HC, Ke LY, Chu CS, Lee AS, Shen MY, Cruz MA, Hsu JF, Cheng KH, Chan HC, Lu J, Lai WT, Sawamura T, Sheu SH, Yen JH, Chen CH. Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. 122: 3632-41. PMID 24030386 DOI: 10.1182/blood-2013-05-504639  0.24
2012 Lee AS, Wang GJ, Chan HC, Chen FY, Chang CM, Yang CY, Lee YT, Chang KC, Chen CH. Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell-released chemokines. Apoptosis : An International Journal On Programmed Cell Death. 17: 1009-18. PMID 22562555 DOI: 10.1007/s10495-012-0726-1  0.24
2012 Zong M, Satoh A, Yu MK, Siu KY, Ng WY, Chan HC, Tanner JA, Yu S. TRAPPC9 mediates the interaction between p150 and COPII vesicles at the target membrane. Plos One. 7: e29995. PMID 22279557 DOI: 10.1371/journal.pone.0029995  0.24
2014 Chan HC, Sun X. SLC26 anion exchangers in uterine epithelial cells and spermatozoa: clues from the past and hints to the future. Cell Biology International. 38: 1-7. PMID 24115633 DOI: 10.1002/cbin.10183  0.2
2013 Liu CH, Lin C, Tsai KJ, Chuang YC, Huang YL, Lee TH, Huang LJ, Chan HC. Biological evaluation of 9-[(6-chloropyridin-4-yl)methyl]-9H-carbazole-3-carbinol as an anticancer agent. Oncology Reports. 29: 1501-9. PMID 23443304 DOI: 10.3892/or.2013.2255  0.2
2015 Hsu TC, Chiu CC, Chang SC, Chan HC, Shi YF, Chen TY, Tzang BS. Human parvovirus B19 VP1u Protein as inflammatory mediators induces liver injury in Naïve Mice. Virulence. 0. PMID 26632342 DOI: 10.1080/21505594.2015.1122165  0.16
2015 Chen YF, Lin YC, Chen JP, Chan HC, Hsu MH, Lin HY, Kuo SC, Huang LJ. Synthesis and biological evaluation of novel 3,9-substituted β-carboline derivatives as anticancer agents. Bioorganic & Medicinal Chemistry Letters. PMID 26235951 DOI: 10.1016/j.bmcl.2015.07.058  0.16
2013 Chen YF, Lin YC, Huang PK, Chan HC, Kuo SC, Lee KH, Huang LJ. Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase. Bioorganic & Medicinal Chemistry. 21: 5064-75. PMID 23867385 DOI: 10.1016/j.bmc.2013.06.046  0.16
2012 Tiong WN, Fong AY, Sim EU, Chan HC, Ong TK, Chang BC, Sim KH. Increased serum levels of interleukin-6 and von Willenbrand Factor in early phase of acute coronary syndrome in a young and multiethnic Malaysian population. Heart Asia. 4: 146-50. PMID 27326052 DOI: 10.1136/heartasia-2012-010131  0.16
2011 Yang LL, Wu JB, Liu ZG, U L, Zeng MS, Yan SS, Chan HC, Xia YF. Preparation of anti-NYD-SP8 rabbit polyclonal antibody and its application in the analysis of NYD-SP8 expression in nasopharyngeal carcinoma cell lines and clinical tissues. Tumori. 97: 655-9. PMID 22158499 DOI: 10.1700/989.10727  0.16
2013 Lin TH, Chou LS, Akamatsu T, Chan HC, Chen CF. An automatic detection algorithm for extracting the representative frequency of cetacean tonal sounds. The Journal of the Acoustical Society of America. 134: 2477-85. PMID 23968045 DOI: 10.1121/1.4816572  0.12
2013 Fang F, Zhang Q, Chan JY, Razali O, Azlan H, Chan HC, Sanderson JE, Xie JM, Yu CM. Early pacing-induced systolic dyssynchrony is a strong predictor of left ventricular adverse remodeling: analysis from the Pacing to Avoid Cardiac Enlargement (PACE) trial. International Journal of Cardiology. 168: 723-8. PMID 22944596 DOI: 10.1016/j.ijcard.2012.08.005  0.12
2016 Lin YT, Yu YM, Chang WC, Chiang SY, Chan HC, Lee MF. Ursolic acid plays a protective role in obesity-induced cardiovascular diseases. Canadian Journal of Physiology and Pharmacology. 1-7. PMID 26991492 DOI: 10.1139/cjpp-2015-0407  0.08
2015 Chau HL, Chan HC, Li TB, Cheung MH, Lam KM, So HS. An Innovative Free-hand Puncture Technique to Reduce Radiation in Percutaneous Nephrolithotomy Using Ultrasound with Navigation System under Magnetic Field: A Single Center Experience in Hong Kong. Journal of Endourology / Endourological Society. PMID 26414736 DOI: 10.1089/end.2015.0296  0.08
2013 Chui WH, Chan HC. Association between self-control and school bullying behaviors among Macanese adolescents. Child Abuse & Neglect. 37: 237-42. PMID 23313077 DOI: 10.1016/j.chiabu.2012.12.003  0.08
2012 Liu ZG, Yi W, Tao YL, Chan HC, Zeng MS, Xia YF. Aurora-A is an efficient marker for predicting poor prognosis in human nasopharyngeal carcinoma with aggressive local invasion: 208 cases with a 10-year follow-up from a single institution. Oncology Letters. 3: 1237-1244. PMID 22783425 DOI: 10.3892/ol.2012.660  0.08
2012 Chan HC, Chui WH. Psychological correlates of violent and non-violent Hong Kong juvenile probationers. Behavioral Sciences & the Law. 30: 103-20. PMID 22362616 DOI: 10.1002/bsl.2003  0.08
2012 Chui WH, Chan HC. The Chinese Youth Attitudes toward Young Drug Users scale: an initial scale development and refinement. Drug and Alcohol Review. 31: 477-82. PMID 22050180 DOI: 10.1111/j.1465-3362.2011.00372.x  0.08
2015 Ho KS, Choi BW, Chan HC, Ching KW. Evaluation of biological, psychosocial, and interventional predictors for success of a smoking cessation programme in Hong Kong. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy of Medicine. PMID 26586081 DOI: 10.12809/hkmj154549  0.04
2015 Chan HC, Jiang D, Fung HH. Role conflict and satisfaction in the work-family context: Age differences in the moderating effect of role commitment. Psych Journal. 4: 20-7. PMID 26263527 DOI: 10.1002/pchj.89  0.04
2015 Lo IC, Chan HC, Qi Z, Ng KL, So C, Tsang SY. TRPV3 Channel Negatively Regulates Cell Cycle Progression and Safeguards the Pluripotency of Embryonic Stem Cells. Journal of Cellular Physiology. PMID 26130157 DOI: 10.1002/jcp.25086  0.04
2015 Chakraborty R, Mukkamalla SK, Gutzmore G, Chan HC. A case of Hodgkin's lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD. Journal of Blood Medicine. 6: 93-7. PMID 25848330 DOI: 10.2147/JBM.S67664  0.04
2015 Chan HC, Beauregard E. Non-Homicidal and Homicidal Sexual Offenders: Prevalence of Maladaptive Personality Traits and Paraphilic Behaviors. Journal of Interpersonal Violence. PMID 25818862 DOI: 10.1177/0886260515575606  0.04
2015 Tan XQ, Goh WP, Venkatachalam I, Goh D, Sridhar R, Chan HC, Archuleta S. Evaluation of a HIV voluntary opt-out screening program in a Singapore hospital. Plos One. 10: e0116987. PMID 25611741 DOI: 10.1371/journal.pone.0116987  0.04
2013 Chui WH, Chan HC. Psychological characteristics of male 14- to 20-year-olds on probation and in a residential home in Hong Kong. Criminal Behaviour and Mental Health : Cbmh. 23: 41-55. PMID 23386575 DOI: 10.1002/cbm.1851  0.04
2012 Xue L, Yen CC, Chang L, Chan HC, Tai BC, Tan SB, Duh HB, Choolani M. An exploratory study of ageing women's perception on access to health informatics via a mobile phone-based intervention. International Journal of Medical Informatics. 81: 637-48. PMID 22658778 DOI: 10.1016/j.ijmedinf.2012.04.008  0.04
2011 Lim S, Xue L, Yen CC, Chang L, Chan HC, Tai BC, Duh HB, Choolani M. A study on Singaporean women's acceptance of using mobile phones to seek health information. International Journal of Medical Informatics. 80: e189-202. PMID 21956003 DOI: 10.1016/j.ijmedinf.2011.08.007  0.04
2016 Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angewandte Chemie (International Ed. in English). PMID 27460867 DOI: 10.1002/anie.201605147  0.01
2016 Klimov VV, Zabkov IV, Pavlov AA, Shiu RC, Chan HC, Guo GY. Manipulation of polarization and spatial properties of light beams with chiral metafilms. Optics Express. 24: 6172-6185. PMID 27136811  0.01
2016 Adjorlolo S, Chan HC, Mensah Agboli J. Adjudicating mentally disordered offenders in Ghana: The criminal and mental health legislations. International Journal of Law and Psychiatry. PMID 26923137 DOI: 10.1016/j.ijlp.2016.02.001  0.01
2015 Adjorlolo S, Chan HC. The Nature of Instrumentality and Expressiveness of Homicide Crime Scene Behaviors: A Review. Trauma, Violence & Abuse. PMID 26206795 DOI: 10.1177/1524838015596528  0.01
2015 Lubana SS, Singh N, Chan HC, Heimann D. Primary neuroendocrine tumor (carcinoid tumor) of the testis: a case report with review of literature. The American Journal of Case Reports. 16: 328-32. PMID 26027014 DOI: 10.12659/AJCR.894463  0.01
2015 Chan HC, Beauregard E, Myers WC. Single-victim and serial sexual homicide offenders: differences in crime, paraphilias and personality traits. Criminal Behaviour and Mental Health : Cbmh. 25: 66-78. PMID 25111158 DOI: 10.1002/cbm.1925  0.01
2015 Chan HC, Lo TW, Zhong LY, Chui WH. Criminal recidivism of incarcerated male nonviolent offenders in Hong Kong. International Journal of Offender Therapy and Comparative Criminology. 59: 121-42. PMID 24052598 DOI: 10.1177/0306624X13502965  0.01
2014 Mariano TY, Chan HC, Myers WC. Corrigendum to "Toward a more holistic understanding of filicide: A multidisciplinary analysis of 32 years of U.S. arrest data" [Forensic Sci. Int. 236 (2014) 46-53]. Forensic Science International. 245: 92-4. PMID 27352962 DOI: 10.1016/j.forsciint.2014.10.030  0.01
2014 Myers WC, Chan HC, Mariano TY. Sexual homicide in the USA committed by juveniles and adults, 1976-2007: Age of arrest and incidence trends over 32 years. Criminal Behaviour and Mental Health : Cbmh. PMID 25523164 DOI: 10.1002/cbm.1947  0.01
2014 Khachatryan N, Heide KM, Hummel EV, Chan HC. Juvenile Sexual Homicide Offenders: Thirty-Year Follow-Up Investigation. International Journal of Offender Therapy and Comparative Criminology. PMID 25245207 DOI: 10.1177/0306624X14552062  0.01
2014 Patel A, Koshy N, Ortega-Barnett J, Chan HC, Kuo YF, Luciano C, Rizzi S, Matulyauskas M, Kania P, Banerjee P, Gasco J. Neurosurgical tactile discrimination training with haptic-based virtual reality simulation. Neurological Research. 36: 1035-9. PMID 24984771 DOI: 10.1179/1743132814Y.0000000405  0.01
2014 Mariano TY, Chan HC, Myers WC. Toward a more holistic understanding of filicide: a multidisciplinary analysis of 32 years of U.S. arrest data. Forensic Science International. 236: 46-53. PMID 24529774 DOI: 10.1016/j.forsciint.2013.12.019  0.01
2013 Chan HC. Letter from the editor: CFTR and male fertility-Impact beyond cystic fibrosis. Spermatogenesis. 3: e26228. PMID 24380037 DOI: 10.4161/spmg.26228  0.01
2013 Chan HC, Frei AM, Myers WC. Female sexual homicide offenders: an analysis of the offender racial profiles in offending process. Forensic Science International. 233: 265-72. PMID 24314528 DOI: 10.1016/j.forsciint.2013.09.011  0.01
2013 Chan HC, Heide KM, Myers WC. Juvenile and adult offenders arrested for sexual homicide: an analysis of victim-offender relationship and weapon used by race. Journal of Forensic Sciences. 58: 85-9. PMID 22563946 DOI: 10.1111/j.1556-4029.2012.02188.x  0.01
2012 Myers WC, Chan HC. Juvenile homosexual homicide. Behavioral Sciences & the Law. 30: 90-102. PMID 22447462 DOI: 10.1002/bsl.2000  0.01
2011 Chan HC, Kendrick J, Leusen FJ. Predictability of the polymorphs of small organic compounds: crystal structure predictions of four benchmark blind test molecules. Physical Chemistry Chemical Physics : Pccp. 13: 20361-70. PMID 21993855 DOI: 10.1039/c1cp22169h  0.01
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