Samuel Benchimol - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pham TD, Ma W, Miller D, Kazakova L, Benchimol S. Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells. Cell Death & Disease. 10: 22. PMID 30622244 DOI: 10.1038/S41419-018-1274-6  0.637
2017 Wheaton K, Campuzano D, Ma W, Sheinis M, Ho B, Brown GW, Benchimol S. Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson Gilford Progeria Syndrome. Molecular and Cellular Biology. PMID 28483909 DOI: 10.1128/Mcb.00659-16  0.525
2013 Kim SS, Benchimol S. HDAC5--a critical player in the p53 acetylation network. Molecular Cell. 52: 289-90. PMID 24207022 DOI: 10.1016/J.Molcel.2013.10.026  0.521
2013 Bagashev A, Fan S, Mukerjee R, Claudio PP, Chabrashvili T, Leng RP, Benchimol S, Sawaya BE. Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein. Cell Cycle (Georgetown, Tex.). 12: 1569-77. PMID 23603988 DOI: 10.4161/Cc.24733  0.518
2013 Nuaaman MM, Benchimol S. Proteasome-independent p53 degradation. Cell Research. 23: 597-8. PMID 23478295 DOI: 10.1038/Cr.2013.38  0.602
2012 Ma W, Lin Y, Xuan W, Iversen PL, Smith LJ, Benchimol S. Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs. Oncogene. 31: 1024-33. PMID 21765469 DOI: 10.1038/Onc.2011.300  0.807
2011 Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, ... ... Benchimol S, et al. Role of Pirh2 in mediating the regulation of p53 and c-Myc. Plos Genetics. 7: e1002360. PMID 22125490 DOI: 10.1371/Journal.Pgen.1002360  0.55
2011 Assaily W, Rubinger DA, Wheaton K, Lin Y, Ma W, Xuan W, Brown-Endres L, Tsuchihara K, Mak TW, Benchimol S. ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Molecular Cell. 44: 491-501. PMID 22055193 DOI: 10.1016/J.Molcel.2011.08.038  0.791
2010 Wheaton K, Muir J, Ma W, Benchimol S. BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence. Aging Cell. 9: 747-60. PMID 20569234 DOI: 10.1111/J.1474-9726.2010.00601.X  0.65
2009 Tai E, Benchimol S. TRIMming p53 for ubiquitination. Proceedings of the National Academy of Sciences of the United States of America. 106: 11431-2. PMID 19584248 DOI: 10.1073/Pnas.0905997106  0.608
2009 Kim IR, Murakami K, Chen NJ, Saibil SD, Matysiak-Zablocki E, Elford AR, Bonnard M, Benchimol S, Jurisicova A, Yeh WC, Ohashi PS. DNA damage- and stress-induced apoptosis occurs independently of PIDD. Apoptosis : An International Journal On Programmed Cell Death. 14: 1039-49. PMID 19575295 DOI: 10.1007/S10495-009-0375-1  0.547
2008 Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH. Molecular basis of Pirh2-mediated p53 ubiquitylation. Nature Structural & Molecular Biology. 15: 1334-42. PMID 19043414 DOI: 10.1038/Nsmb.1521  0.516
2007 Bradley G, Tremblay S, Irish J, MacMillan C, Baker G, Gullane P, Benchimol S. The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma. British Journal of Cancer. 96: 1425-32. PMID 17437012 DOI: 10.1038/Sj.Bjc.6603745  0.601
2006 Assaily W, Benchimol S. Differential utilization of two ATP-generating pathways is regulated by p53. Cancer Cell. 10: 4-6. PMID 16843260 DOI: 10.1016/J.Ccr.2006.06.014  0.497
2006 Brown L, Benchimol S. The involvement of MAPK signaling pathways in determining the cellular response to p53 activation: cell cycle arrest or apoptosis. The Journal of Biological Chemistry. 281: 3832-40. PMID 16330547 DOI: 10.1074/Jbc.M507951200  0.641
2006 Lin Y, Leng RP, Benchimol S. Identification of p53-regulated genes by the method of differential display. Methods in Molecular Biology (Clifton, N.J.). 317: 193-206. PMID 16264230 DOI: 10.1385/1-59259-968-0:193  0.796
2005 Berube C, Boucher LM, Ma W, Wakeham A, Salmena L, Hakem R, Yeh WC, Mak TW, Benchimol S. Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proceedings of the National Academy of Sciences of the United States of America. 102: 14314-20. PMID 16183742 DOI: 10.1073/Pnas.0506475102  0.531
2005 Ho JS, Ma W, Mao DY, Benchimol S. p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Molecular and Cellular Biology. 25: 7423-31. PMID 16107691 DOI: 10.1128/Mcb.25.17.7423-7431.2005  0.6
2005 Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S, Mak TW. Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Cancer Research. 65: 6685-91. PMID 16061649 DOI: 10.1158/0008-5472.Can-04-4223  0.676
2004 Benchimol S. p53--an examination of sibling support in apoptosis control. Cancer Cell. 6: 3-4. PMID 15261135 DOI: 10.1016/J.Ccr.2004.07.002  0.634
2003 Bristow RG, Peacock J, Jang A, Kim J, Hill RP, Benchimol S. Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF ras-transformants-expressing gain of function MTp53. Oncogene. 22: 2960-6. PMID 12771947 DOI: 10.1038/Sj.Onc.1206405  0.557
2003 Ho J, Benchimol S. Transcriptional repression mediated by the p53 tumour suppressor. Cell Death and Differentiation. 10: 404-8. PMID 12719716 DOI: 10.1038/Sj.Cdd.4401191  0.556
2003 Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK. Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proceedings of the National Academy of Sciences of the United States of America. 100: 5431-6. PMID 12702766 DOI: 10.1073/Pnas.0530308100  0.6
2003 Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell. 112: 779-91. PMID 12654245 DOI: 10.1016/S0092-8674(03)00193-4  0.817
2003 Wieler S, Gagné JP, Vaziri H, Poirier GG, Benchimol S. Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation. The Journal of Biological Chemistry. 278: 18914-21. PMID 12642583 DOI: 10.1074/Jbc.M211641200  0.631
2002 Lin Y, Brown L, Hedley DW, Barber DL, Benchimol S. The death-promoting activity of p53 can be inhibited by distinct signaling pathways. Blood. 100: 3990-4000. PMID 12393587 DOI: 10.1182/Blood-2002-02-0504  0.78
2002 Gangopadhyay S, Jalali F, Reda D, Peacock J, Bristow RG, Benchimol S. Expression of different mutant p53 transgenes in neuroblastoma cells leads to different cellular responses to genotoxic agents. Experimental Cell Research. 275: 122-31. PMID 11925110 DOI: 10.1006/Excr.2002.5493  0.651
2002 Benchimol S. p53-dependent pathways of apoptosis. Cell Death and Differentiation. 8: 1049-51. PMID 11687883 DOI: 10.1038/Sj.Cdd.4400918  0.569
2001 Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S, Mak TW. Regulation of PTEN transcription by p53. Molecular Cell. 8: 317-25. PMID 11545734 DOI: 10.1016/S1097-2765(01)00323-9  0.811
2001 Bradley G, Irish J, MacMillan C, Mancer K, Witterick I, Hartwick W, Gullane P, Kamel-Reid S, Benchimol S. Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma. Oncogene. 20: 654-8. PMID 11313998 DOI: 10.1038/Sj.Onc.1204131  0.568
2001 Davison TS, Nie X, Ma W, Lin Y, Kay C, Benchimol S, Arrowsmith CH. Structure and functionality of a designed p53 dimer. Journal of Molecular Biology. 307: 605-17. PMID 11254385 DOI: 10.1006/Jmbi.2001.4450  0.776
2000 Lin Y, Ma W, Benchimol S. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nature Genetics. 26: 122-7. PMID 10973264 DOI: 10.1038/79102  0.811
2000 Abraham J, Kelly J, Thibault P, Benchimol S. Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry. Journal of Molecular Biology. 295: 853-64. PMID 10656795 DOI: 10.1006/Jmbi.1999.3415  0.529
1999 Vaziri H, Benchimol S. Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase. Oncogene. 18: 7676-7680. PMID 10618707 DOI: 10.1038/Sj.Onc.1203016  0.522
1999 Fu L, Ma W, Benchimol S. A translation repressor element resides in the 3' untranslated region of human p53 mRNA. Oncogene. 18: 6419-6424. PMID 10597243 DOI: 10.1038/Sj.Onc.1203064  0.522
1999 Abraham J, Spaner D, Benchimol S. Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells. Oncogene. 18: 1521-7. PMID 10102621 DOI: 10.1038/Sj.Onc.1202454  0.54
1999 Vaziri H, Squire JA, Pandita TK, Bradley G, Kuba RM, Zhang H, Gulyas S, Hill RP, Nolan GP, Benchimol S. Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts Molecular and Cellular Biology. 19: 2373-2379. PMID 10022923 DOI: 10.1128/Mcb.19.3.2373  0.513
1998 Bristow RG, Hu Q, Jang A, Chung S, Peacock J, Benchimol S, Hill R. Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation Oncogene. 16: 1789-1802. PMID 9583677 DOI: 10.1038/Sj.Onc.1201935  0.47
1998 Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span Current Biology. 8: 279-282. PMID 9501072 DOI: 10.1016/S0960-9822(98)70109-5  0.353
1998 Sutcliffe T, Fu L, Abraham J, Vaziri H, Benchimol S. A Functional Wild-Type p53 Gene Is Expressed in Human Acute Myeloid Leukemia Cell Lines Blood. 92: 2977-2979. DOI: 10.1182/Blood.V92.8.2977.Spll5_2977_2979  0.566
1997 Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG, Benchimol S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. The Embo Journal. 16: 6018-33. PMID 9312059 DOI: 10.1093/Emboj/16.19.6018  0.62
1997 Czarnota GJ, Kolios MC, Vaziri H, Benchimol S, Ottensmeyer FP, Sherar MD, Hunt JW. Ultrasonic biomicroscopy of viable, dead and apoptotic cells. Ultrasound in Medicine & Biology. 23: 961-5. PMID 9301000 DOI: 10.1016/S0301-5629(97)00067-7  0.353
1997 Fu L, Benchimol S. Participation of the human p53 3'UTR in translational repression and activation following gamma-irradiation. The Embo Journal. 16: 4117-25. PMID 9233820 DOI: 10.1093/Emboj/16.13.4117  0.596
1997 Lin Y, Benchimol S. p53-mediated cell cycle arrest and apoptosis. Leukemia. 11: 324-6. PMID 9209379  0.767
1996 Bristow RG, Benchimol S, Hill RP. The p53 gene as a modifier of intrinsic radiosensitivity: Implications for radiotherapy Radiotherapy and Oncology. 40: 197-223. PMID 8940748 DOI: 10.1016/0167-8140(96)01806-3  0.528
1996 Bristow RG, Benchimol S, Hill R. p53 protein expression or protein function? Re: AWWAD et al. IJROBP 34(2):323-332; 1996 [1] International Journal of Radiation Oncology Biology Physics. 35: 1123-1124. PMID 8751424 DOI: 10.1016/0360-3016(96)85887-1  0.386
1996 Vaziri H, Benchimol S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Experimental Gerontology. 31: 295-301. PMID 8706799 DOI: 10.1016/0531-5565(95)02025-X  0.509
1996 Chang H, Blondal JA, Benchimol S, Minden MD, Messner HA. p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines. Leukemia & Lymphoma. 19: 165-71. PMID 8574164 DOI: 10.3109/10428199509059672  0.442
1996 Bristow RG, Brail L, Jang A, Peacock J, Chung S, Benchimol S, Hill RP. P53-mediated radioresistance does not correlate with metastatic potential in tumorigenic rat embryo cell lines following oncogene transfection International Journal of Radiation Oncology Biology Physics. 34: 341-355. PMID 8567335 DOI: 10.1016/0360-3016(95)02023-3  0.517
1996 Fu L, Minden MD, Benchimol S. Translational regulation of human p53 gene expression. The Embo Journal. 15: 4392-4401. DOI: 10.1002/J.1460-2075.1996.Tb00812.X  0.622
1995 Peacock JW, Chung S, Bristow RG, Hill RP, Benchimol S. The p53-mediated G1 checkpoint is retained in tumorigenic rat embryo fibroblast clones transformed by the human papillomavirus type 16 E7 gene and EJ-ras Molecular and Cellular Biology. 15: 1446-1454. PMID 7862138 DOI: 10.1128/Mcb.15.3.1446  0.584
1995 Lin Y, Benchimol S. Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest. Molecular and Cellular Biology. 15: 6045-54. PMID 7565757 DOI: 10.1128/Mcb.15.11.6045  0.803
1994 Benchimol S, Ling V. P-glycoprotein and tumor progression. Journal of the National Cancer Institute. 86: 814-6. PMID 7910218 DOI: 10.1093/Jnci/86.11.814  0.497
1994 Chang H, Benchimol S, Minden M, Messner H. Alterations of p53 and c-myc in the clonal evolution of malignant lymphoma Blood. 83: 452-459. DOI: 10.1182/Blood.V83.2.452.Bloodjournal832452  0.622
1994 Bristow R, Jang A, Peacock J, Chung S, Benchimol S, Hill RP. Mutant p53 increases radioresistance in transfected rat embryo fibroblasts: Implications for radiotherapy International Journal of Radiation Oncology Biology Physics. 30: 225. DOI: 10.1016/0360-3016(94)90750-1  0.456
1994 Peacock J, Benchimol S. Mutation of the endogenous p53 gene in cells transformed by HPV-16 E7 and EJ c-ras confers a growth advantage involving an autocrine mechanism. The Embo Journal. 13: 1084-1092. DOI: 10.1002/J.1460-2075.1994.Tb06357.X  0.502
1993 Slingerland JM, Jenkins JR, Benchimol S. The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation. The Embo Journal. 12: 1029-37. PMID 8458321 DOI: 10.1002/J.1460-2075.1993.Tb05744.X  0.535
1993 Johnson P, Chung S, Benchimol S. Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin. Molecular and Cellular Biology. 13: 1456-63. PMID 8441390 DOI: 10.1128/Mcb.13.3.1456  0.487
1993 Ilantzis C, Thomson DM, Michaelidou A, Benchimol S, Stanners CP. Identification of a human cancer related organ-specific neoantigen. Microbiology and Immunology. 37: 119-28. PMID 7684807 DOI: 10.1111/j.1348-0421.1993.tb03188.x  0.351
1991 Slingerland JM, Minden MD, Benchimol S. Mutation of the p53 gene in human acute myelogenous leukemia Blood. 77: 1500-1507. PMID 2009369 DOI: 10.1182/Blood.V77.7.1500.Bloodjournal7771500  0.583
1991 Johnson P, Gray D, Mowat M, Benchimol S. Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells. Molecular and Cellular Biology. 11: 1-11. PMID 1986214 DOI: 10.1128/Mcb.11.1.1  0.649
1991 Slingerland JM, Benchimol S. Transforming activity of mutant human p53 alleles Journal of Cellular Physiology. 148: 391-395. PMID 1918170 DOI: 10.1002/Jcp.1041480309  0.528
1990 Lane DP, Benchimol S. p53: oncogene or anti-oncogene? Genes & Development. 4: 1-8. PMID 2137806 DOI: 10.1101/Gad.4.1.1  0.554
1990 Munroe DG, Peacock JW, Benchimol S. Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles. Molecular and Cellular Biology. 10: 3307-13. PMID 1694008 DOI: 10.1128/Mcb.10.7.3307  0.577
1989 Ahuja H, Bar-Eli M, Advani SH, Benchimol S, Cline MJ. Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 86: 6783-7. PMID 2771957 DOI: 10.1073/Pnas.86.17.6783  0.492
1988 Mak I, Mak S, Benchimol S. Expression of the cellular p53 protein in cells transformed by adenovirus 12 and viral DNA fragments Virology. 163: 201-204. PMID 2964754 DOI: 10.1016/0042-6822(88)90248-6  0.525
1987 Rovinski B, Munroe D, Peacock J, Mowat M, Bernstein A, Benchimol S. Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation. Molecular and Cellular Biology. 7: 847-53. PMID 3547084 DOI: 10.1128/Mcb.7.2.847  0.592
1987 Filmus J, Benchimol S, Buick RN. Comparative analysis of the involvement of p53, c-myc and c-fos in epidermal growth factor-mediated signal transduction Experimental Cell Research. 169: 554-559. PMID 2435565 DOI: 10.1016/0014-4827(87)90215-1  0.481
1987 Chow V, Ben-David Y, Bernstein A, Benchimol S, Mowat M. Multistage Friend erythroleukemia: independent origin of tumor clones with normal or rearranged p53 cellular oncogenes. Journal of Virology. 61: 2777-2781. DOI: 10.1128/Jvi.61.9.2777-2781.1987  0.562
1986 Duthu A, Ehrhart JC, Benchimol S, Chandrasekaran K, May P. P53-transformation-related protein: kinetics of synthesis and accumulation in SV40-infected primary mouse kidney cell cultures. Virology. 147: 275-86. PMID 3000070 DOI: 10.1016/0042-6822(85)90130-8  0.531
1986 Smith LJ, McCulloch EA, Benchimol S. Expression of the p53 oncogene in acute myeloblastic leukemia. The Journal of Experimental Medicine. 164: 751-61. PMID 2427633 DOI: 10.1084/jem.164.3.751  0.492
1985 Mowat M, Cheng A, Kimura N, Bernstein A, Benchimol S. Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus Nature. 314: 633-636. PMID 3990796 DOI: 10.1038/314633A0  0.596
1985 Benchimol S, Lamb P, Crawford LV, Sheer D, Shows TB, Bruns GA, Peacock J. Transformation associated p53 protein is encoded by a gene on human chromosome 17. Somatic Cell and Molecular Genetics. 11: 505-10. PMID 2994241 DOI: 10.1007/BF01534845  0.37
1984 Matlashewski G, Lamb P, Pim D, Peacock J, Crawford L, Benchimol S. Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene. The Embo Journal. 3: 3257-3262. DOI: 10.1002/j.1460-2075.1984.tb02287.x  0.427
1982 Sumner-Smith M, Benchimol S, Murialdo H, Becker A. The ben gene of bacteriophage λ: Mapping, identification and control of synthesis Journal of Molecular Biology. 160: 1-22. PMID 6294300 DOI: 10.1016/0022-2836(82)90128-0  0.368
1982 Benchimol S, Pim D, Crawford L. Radioimmunoassay of the cellular protein p53 in mouse and human cell lines. The Embo Journal. 1: 1055-1062. DOI: 10.1002/j.1460-2075.1982.tb01296.x  0.415
1978 Benchimol S, Becker A, Murialdo H, Gold M. The role of the bacteriophage λ FI gene product during phage head assembly in Vitro Virology. 91: 205-221. PMID 369114 DOI: 10.1016/0042-6822(78)90370-7  0.325
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