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Jonathan L. Coloff, Ph.D. - Publications

Affiliations: 
2010 Pharmacology Duke University, Durham, NC 
Area:
Pharmacology, Molecular Biology, Oncology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Lietuvninkas L, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. ASCT2 is a major contributor to serine uptake in cancer cells. Cell Reports. 43: 114552. PMID 39068660 DOI: 10.1016/j.celrep.2024.114552  0.771
2024 Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, ... ... Coloff JL, et al. Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy. Jci Insight. PMID 38815134 DOI: 10.1172/jci.insight.174329  0.762
2023 Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. ASCT2 is the primary serine transporter in cancer cells. Biorxiv : the Preprint Server For Biology. PMID 37873453 DOI: 10.1101/2023.10.09.561530  0.776
2023 Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, ... ... Coloff JL, et al. Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy. Biorxiv : the Preprint Server For Biology. PMID 37546939 DOI: 10.1101/2023.07.26.550731  0.761
2022 de Wet L, Williams A, Gillard M, Kregel S, Lamperis S, Gutgesell LC, Vellky JE, Brown R, Conger K, Paner GP, Wang H, Platz EA, De Marzo AM, Mu P, Coloff JL, et al. Correction to: SOX2 mediates metabolic reprogramming of prostate cancer cells. Oncogene. 41: 1234. PMID 35145235 DOI: 10.1038/s41388-022-02228-7  0.308
2022 de Wet L, Williams A, Gillard M, Kregel S, Lamperis S, Gutgesell LC, Vellky JE, Brown R, Conger K, Paner GP, Wang H, Platz EE, De Marzo AM, Mu P, Coloff JL, et al. SOX2 mediates metabolic reprogramming of prostate cancer cells. Oncogene. PMID 35067686 DOI: 10.1038/s41388-021-02157-x  0.312
2022 Choi BH, Rawat V, Högström J, Burns PA, Conger KO, Ozgurses ME, Patel JM, Mehta TS, Warren A, Selfors LM, Muranen T, Coloff JL. Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors. Cell Reports. 38: 110278. PMID 35045283 DOI: 10.1016/j.celrep.2021.110278  0.753
2021 Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, et al. Differential Substrate Use in EGF- and Oncogenic KRAS-Stimulated Human Mammary Epithelial Cells. The Febs Journal. PMID 33811729 DOI: 10.1111/febs.15858  0.44
2019 Choi BH, Coloff JL. The Diverse Functions of Non-Essential Amino Acids in Cancer. Cancers. 11. PMID 31096630 DOI: 10.3390/cancers11050675  0.307
2019 Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metabolism. PMID 30799286 DOI: 10.1016/J.Cmet.2019.01.020  0.414
2018 Coloff JL. Glutamate Dehydrogenase to the Rescue. Molecular Cell. 69: 1-2. PMID 29304329 DOI: 10.1016/j.molcel.2017.12.015  0.326
2017 Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 6. PMID 29239720 DOI: 10.7554/Elife.27293  0.398
2017 Coloff JL, Brugge JS. Metabolic changes promote rejection of oncogenic cells. Nature Cell Biology. 19: 414-415. PMID 28446818 DOI: 10.1038/Ncb3521  0.407
2017 Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY. Starved epithelial cells uptake extracellular matrix for survival. Nature Communications. 8: 13989. PMID 28071763 DOI: 10.1038/Ncomms13989  0.363
2016 Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS. ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP. Cancer Research. PMID 27913436 DOI: 10.1158/0008-5472.Can-16-0155  0.468
2016 Coloff JL, Brugge JS. How tumor cells cope with the metabolic stress of leaving home. Cell Research. PMID 27216116 DOI: 10.1038/Cr.2016.61  0.359
2016 Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS. Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells. Cell Metabolism. PMID 27133130 DOI: 10.1016/J.Cmet.2016.03.016  0.359
2016 Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, et al. Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. PMID 27002169 DOI: 10.1083/Jcb.20150304403082016C  0.345
2015 Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. 210: 705-16. PMID 26323688 DOI: 10.1083/Jcb.201503044  0.542
2014 Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. Plos One. 9: e98705. PMID 24879016 DOI: 10.1371/Journal.Pone.0098705  0.628
2014 Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska IA, Yu J, Kwiatkowski DJ, Locasale JW, Asara JM, Choi AM, Finkel T, Henske EP. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Molecular Cancer Research : McR. 12: 48-57. PMID 24296756 DOI: 10.1158/1541-7786.Mcr-13-0258-T  0.453
2012 Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 149: 656-70. PMID 22541435 DOI: 10.1016/J.Cell.2012.01.058  0.356
2011 Grassian AR, Coloff JL, Brugge JS. Extracellular matrix regulation of metabolism and implications for tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 76: 313-24. PMID 22105806 DOI: 10.1101/Sqb.2011.76.010967  0.431
2011 Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes & Development. 25: 1716-33. PMID 21852536 DOI: 10.1101/Gad.16771811  0.467
2011 Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer Research. 71: 5204-13. PMID 21670080 DOI: 10.1158/0008-5472.Can-10-4531  0.749
2011 Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Molecular Biology of the Cell. 22: 1207-16. PMID 21325626 DOI: 10.1091/Mbc.E10-07-0567  0.556
2011 Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. The Journal of Biological Chemistry. 286: 5921-33. PMID 21159778 DOI: 10.1074/Jbc.M110.179101  0.788
2011 Altman BJ, Jacobs SR, Mason EF, Michalek RD, MacIntyre AN, Coloff JL, Ilkayeva O, Jia W, He YW, Rathmell JC. Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. Oncogene. 30: 1855-67. PMID 21151168 DOI: 10.1038/Onc.2010.561  0.821
2011 Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC. Abstract LB-261: Maintenance of aerobic glycolysis provides selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl through suppression of p53 activation Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-261  0.846
2010 Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Research. 70: 8066-76. PMID 20876800 DOI: 10.1158/0008-5472.Can-10-0608  0.842
2010 Ke H, Harris R, Coloff JL, Jin JY, Leshin B, Miliani de Marval P, Tao S, Rathmell JC, Hall RP, Zhang JY. The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer Research. 70: 3080-8. PMID 20354187 DOI: 10.1158/0008-5472.Can-09-2923  0.639
2009 Altman BJ, Wofford JA, Zhao Y, Coloff JL, Ferguson EC, Wieman HL, Day AE, Ilkayeva O, Rathmell JC. Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. Molecular Biology of the Cell. 20: 1180-91. PMID 19109422 DOI: 10.1091/Mbc.E08-08-0829  0.76
2008 Zhao Y, Coloff JL, Ferguson EC, Jacobs SR, Cui K, Rathmell JC. Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation Journal of Biological Chemistry. 283: 36344-36353. PMID 18990690 DOI: 10.1074/Jbc.M803580200  0.836
2008 MacIver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival Journal of Leukocyte Biology. 84: 949-957. PMID 18577716 DOI: 10.1189/Jlb.0108024  0.787
2007 Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Molecular and Cellular Biology. 27: 4328-39. PMID 17371841 DOI: 10.1128/Mcb.00153-07  0.762
2006 Coloff JL, Rathmell JC. Metabolic regulation of Akt: roles reversed. The Journal of Cell Biology. 175: 845-7. PMID 17158959 DOI: 10.1083/Jcb.200610119  0.682
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