David M. Sabatini - Publications

Affiliations: 
Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
regulators of growth
Website:
https://biology.mit.edu/people/david_sabatini

250 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM. Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity. Nature. PMID 35017686 DOI: 10.1038/s41586-021-03487-2  0.665
2021 Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona F, Dafinger C, Houillier P, Jones D, Kleinerüschkamp F, Oh J, Godefroid N, Eltan M, Güran T, Burtey S, Parotte MC, ... ... Sabatini D, et al. mTOR-Activating Mutations in RRAGD are Causative for Kidney Tubulopathy and Cardiomyopathy. Journal of the American Society of Nephrology : Jasn. PMID 34607910 DOI: 10.1681/ASN.2021030333  0.47
2021 de la Calle Arregui C, Plata-Gómez AB, Deleyto-Seldas N, García F, Ortega-Molina A, Abril-Garrido J, Rodriguez E, Nemazanyy I, Tribouillard L, de Martino A, Caleiras E, Campos-Olivas R, Mulero F, Laplante M, Muñoz J, ... ... Sabatini DM, et al. Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling. Nature Communications. 12: 3660. PMID 34135321 DOI: 10.1038/s41467-021-23857-8  0.651
2021 Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, ... Sabatini DM, et al. disrupts intracellular lipid homeostasis in human iPSC-derived glia. Science Translational Medicine. 13. PMID 33658354 DOI: 10.1126/scitranslmed.aaz4564  0.776
2020 Kory N, Uit de Bos J, van der Rijt S, Jankovic N, Güra M, Arp N, Pena IA, Prakash G, Chan SH, Kunchok T, Lewis CA, Sabatini DM. MCART1/SLC25A51 is required for mitochondrial NAD transport. Science Advances. 6. PMID 33087354 DOI: 10.1126/Sciadv.Abe5310  0.755
2020 Fassl A, Brain C, Abu-Remaileh M, Stukan I, Butter D, Stepien P, Feit AS, Bergholz J, Michowski W, Otto T, Sheng Q, Loo A, Michael W, Tiedt R, DeAngelis C, ... ... Sabatini DM, et al. Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Science Advances. 6: eabb2210. PMID 32704543 DOI: 10.1126/Sciadv.Abb2210  0.749
2020 Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S. Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells. Scientific Reports. 10: 12054. PMID 32694612 DOI: 10.1038/S41598-020-69376-2  0.526
2020 Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, ... ... Sabatini DM, et al. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discovery. PMID 32571778 DOI: 10.1158/2159-8290.Cd-19-1228  0.692
2020 Surface LE, Burrow DT, Li J, Park J, Kumar S, Lyu C, Song N, Yu Z, Rajagopal A, Bae Y, Lee BH, Mumm S, Gu CC, Baker JC, Mohseni M, ... ... Sabatini DM, et al. regulates the action of nitrogen-containing bisphosphonates on bone. Science Translational Medicine. 12. PMID 32434850 DOI: 10.1126/Scitranslmed.Aav9166  0.628
2020 Helman A, Cangelosi AL, Davis JC, Pham Q, Rothman A, Faust AL, Straubhaar JR, Sabatini DM, Melton DA. A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion. Cell Metabolism. PMID 32375022 DOI: 10.1016/j.cmet.2020.04.004  0.335
2020 Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA. Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging. PMID 32268298 DOI: 10.18632/aging.102976  0.526
2020 Kanarek N, Petrova B, Sabatini DM. Dietary modifications for enhanced cancer therapy. Nature. 579: 507-517. PMID 32214253 DOI: 10.1038/s41586-020-2124-0  0.303
2020 Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. The Journal of Biological Chemistry. 295: 2886. PMID 32111721 DOI: 10.1074/Jbc.Aac120.012837  0.472
2020 Chivukula RR, Montoro DT, Leung HM, Yang J, Shamseldin HE, Taylor MS, Dougherty GW, Zariwala MA, Carson J, Daniels MLA, Sears PR, Black KE, Hariri LP, Almogarri I, Frenkel EM, ... ... Sabatini DM, et al. Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature Medicine. PMID 31996837 DOI: 10.1038/S41591-020-0773-Z  0.693
2020 Chivukula RR, Montoro DT, Leung HM, Yang J, Shamseldin HE, Taylor MS, Dougherty GW, Zariwala MA, Carson J, Daniels MLA, Sears PR, Black KE, Hariri LP, Almogarri I, Frenkel EM, ... ... Sabatini DM, et al. A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature Medicine. PMID 31959991 DOI: 10.1038/S41591-019-0730-X  0.755
2020 Liu GY, Sabatini DM. mTOR at the nexus of nutrition, growth, ageing and disease. Nature Reviews. Molecular Cell Biology. PMID 31937935 DOI: 10.1038/s41580-019-0199-y  0.395
2019 Condon KJ, Sabatini DM. Nutrient regulation of mTORC1 at a glance. Journal of Cell Science. 132. PMID 31722960 DOI: 10.1242/jcs.222570  0.404
2019 Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM. Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell. PMID 31704029 DOI: 10.1016/J.Cell.2019.10.036  0.783
2019 Do MH, Wang X, Zhang X, Chou C, Nixon BG, Capistrano KJ, Peng M, Efeyan A, Sabatini DM, Li MO. Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance. The Journal of Experimental Medicine. PMID 31649036 DOI: 10.1084/jem.20190848  0.323
2019 Anandapadamanaban M, Masson GR, Perisic O, Berndt A, Kaufman J, Johnson CM, Santhanam B, Rogala KB, Sabatini DM, Williams RL. Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science (New York, N.Y.). 366: 203-210. PMID 31601764 DOI: 10.1126/Science.Aax3939  0.79
2019 Rogala KB, Gu X, Kedir JF, Abu-Remaileh M, Bianchi LF, Bottino AMS, Dueholm R, Niehaus A, Overwijn D, Fils AP, Zhou SX, Leary D, Laqtom NN, Brignole EJ, Sabatini DM. Structural basis for the docking of mTORC1 on the lysosomal surface. Science (New York, N.Y.). PMID 31601708 DOI: 10.1126/Science.Aay0166  0.786
2019 Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, ... ... Sabatini DM, et al. Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. Nature. PMID 31292548 DOI: 10.1038/S41586-019-1383-0  0.727
2019 Kikani CK, Wu X, Fogarty S, Kang SAW, Dephoure N, Gygi SP, Sabatini DM, Rutter J. Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program. Proceedings of the National Academy of Sciences of the United States of America. PMID 31072927 DOI: 10.1073/Pnas.1804013116  0.336
2019 Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. PMID 30760928 DOI: 10.1038/S41586-019-0945-5  0.675
2019 Shen K, Valenstein ML, Gu X, Sabatini DM. Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. The Journal of Biological Chemistry. PMID 30651352 DOI: 10.1074/Jbc.Ac119.007382  0.569
2019 Adelmann CH, Wang T, Sabatini DM, Lander ES. Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines. Methods in Molecular Biology (Clifton, N.J.). 1907: 125-136. PMID 30542996 DOI: 10.1007/978-1-4939-8967-6_10  0.318
2018 Heo JM, Ordureau A, Swarup S, Paulo JA, Shen K, Sabatini DM, Harper JW. RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway. Science Advances. 4: eaav0443. PMID 30627666 DOI: 10.1126/Sciadv.Aav0443  0.569
2018 Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW. MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 30541894 DOI: 10.1073/Pnas.1816656115  0.789
2018 Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science (New York, N.Y.). 362. PMID 30442778 DOI: 10.1126/Science.Aat9528  0.788
2018 Shen K, Sabatini DM. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 115: 9545-9550. PMID 30181260 DOI: 10.1073/Pnas.1811727115  0.537
2018 Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM. Histidine catabolism is a major determinant of methotrexate sensitivity. Nature. PMID 29995852 DOI: 10.1038/S41586-018-0316-7  0.748
2018 Wedel J, Bruneau S, Liu K, Kong SW, Sage PT, Sabatini DM, Laplante M, Briscoe DM. Deptor modulates activation responses in CD4 T cells and enhances immunoregulation following transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 29969188 DOI: 10.1111/Ajt.14995  0.636
2018 Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... ... Sabatini DM, et al. Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. PMID 29849139 DOI: 10.1038/S41586-018-0187-Y  0.745
2018 Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates. Elife. 7. PMID 29745899 DOI: 10.7554/Elife.36620  0.71
2018 Mihaylova MM, Cheng CW, Cao AQ, Tripathi S, Mana MD, Bauer-Rowe KE, Abu-Remaileh M, Clavain L, Erdemir A, Lewis CA, Freinkman E, Dickey AS, La Spada AR, Huang Y, Bell GW, ... ... Sabatini DM, et al. Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell. 22: 769-778.e4. PMID 29727683 DOI: 10.1016/J.Stem.2018.04.001  0.768
2018 Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM. NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Science (New York, N.Y.). PMID 29700228 DOI: 10.1126/Science.Aar2663  0.74
2018 Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature. PMID 29590090 DOI: 10.1038/Nature26158  0.57
2018 Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorganic & Medicinal Chemistry. PMID 29555419 DOI: 10.1016/j.bmc.2018.02.016  0.719
2018 Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R. Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Molecular Cell. 69: 610-621.e5. PMID 29452640 DOI: 10.1016/J.Molcel.2018.01.024  0.658
2018 Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Author response: Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates Elife. DOI: 10.7554/Elife.36620.020  0.694
2018 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato RL. Abstract NG02: NFS1 undergoes positive selection in lung tumors and protects cells from ferroptosis Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Ng02  0.663
2018 Ahn WS, Dong W, Zhang Z, Cantor JR, Sabatini DM, Iliopoulos O, Stephanopoulos G. Glyceraldehyde 3-phosphate dehydrogenase modulates nonoxidative pentose phosphate pathway to provide anabolic precursors in hypoxic tumor cells Aiche Journal. 64: 4289-4296. DOI: 10.1002/Aic.16423  0.325
2017 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. PMID 29168506 DOI: 10.1038/Nature24637  0.654
2017 Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Molecular Cell. 68: 821. PMID 29149601 DOI: 10.1016/j.molcel.2017.10.031  0.429
2017 Gu X, Orozco JM, Saxton RA, Condon KJ, Liu GY, Krawczyk PA, Scaria SM, Harper JW, Gygi SP, Sabatini DM. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science (New York, N.Y.). 358: 813-818. PMID 29123071 DOI: 10.1126/Science.Aao3265  0.399
2017 Sabatini DM. Twenty-five years of mTOR: Uncovering the link from nutrients to growth. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078414 DOI: 10.1073/pnas.1716173114  0.386
2017 Abu-Remaileh M, Wyant GA, Kim C, Laqtom NN, Abbasi M, Chan SH, Freinkman E, Sabatini DM. Lysosomal metabolomics reveals V-ATPase and mTOR-dependent regulation of amino acid efflux from lysosomes. Science (New York, N.Y.). PMID 29074583 DOI: 10.1126/Science.Aan6298  0.728
2017 Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS. A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nature Chemical Biology. PMID 29058724 DOI: 10.1038/Nchembio.2499  0.654
2017 Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Molecular Cell. PMID 29056322 DOI: 10.1016/J.Molcel.2017.09.026  0.542
2017 Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM. mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Cell. 171: 642-654.e12. PMID 29053970 DOI: 10.1016/J.Cell.2017.09.046  0.735
2017 Wolfson RL, Sabatini DM. The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. Cell Metabolism. 26: 301-309. PMID 28768171 DOI: 10.1016/j.cmet.2017.07.001  0.307
2017 Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD. Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. Immunity. 46: 1045-1058.e6. PMID 28636954 DOI: 10.1016/J.Immuni.2017.06.005  0.369
2017 Caron A, Mouchiroud M, Gautier N, Labbé SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gélinas Y, Marette A, Richard D, Sabatini DM, Laplante M. Loss of hepatic DEPTOR alters the metabolic transition to fasting. Molecular Metabolism. 6: 447-458. PMID 28462079 DOI: 10.1016/J.Molmet.2017.02.005  0.769
2017 Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, ... ... Sabatini DM, et al. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396387 DOI: 10.1073/Pnas.1617922114  0.799
2017 Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint A, Lewis CA, Sabatini DM. Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell. 169: 258-272.e17. PMID 28388410 DOI: 10.1016/J.Cell.2017.03.023  0.727
2017 Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 168: 960-976. PMID 28283069 DOI: 10.1016/j.cell.2017.02.004  0.401
2017 Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. PMID 28199306 DOI: 10.1038/Nature21423  0.794
2017 Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. PMID 28162770 DOI: 10.1016/j.cell.2017.01.013  0.322
2017 Sabatini DM. Abstract IA02: Regulation of growth by the mTOR pathway Cancer Research. 77. DOI: 10.1158/1538-7445.Transcontrol16-Ia02  0.427
2017 Kanarek N, Freinkman E, Cantor J, Abu-Remaileh M, Wang T, Sabatini DM. Abstract 4988: Genome-wide CRISPR screen and metabolite profiling reveal a new mechanism of methotrexate sensitivity Cancer Research. 77: 4988-4988. DOI: 10.1158/1538-7445.Am2017-4988  0.742
2016 Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS. ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP. Cancer Research. PMID 27913436 DOI: 10.1158/0008-5472.Can-16-0155  0.383
2016 Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM. Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell. 166: 1324-1337.e11. PMID 27565352 DOI: 10.1016/J.Cell.2016.07.040  0.652
2016 Saxton RA, Chantranupong L, Knockenhauer KE, Schwartz TU, Sabatini DM. Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. Nature. PMID 27487210 DOI: 10.1038/Nature19079  0.395
2016 Chantranupong L, Sabatini DM. Cell biology: The TORC1 pathway to protein destruction. Nature. PMID 27462809 DOI: 10.1038/nature18919  0.356
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, ... ... Sabatini DM, et al. Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. 12: 656. PMID 27434767 DOI: 10.1038/Nchembio0816-656  0.751
2016 Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Marinez PA, McCord JM, Miller BF, ... ... Sabatini DM, et al. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell. PMID 27312235 DOI: 10.1111/Acel.12496  0.581
2016 Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, ... ... Sabatini DM, et al. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. PMID 27184401 DOI: 10.1016/J.Stem.2016.04.002  0.588
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, ... ... Sabatini DM, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. PMID 27110680 DOI: 10.1038/Nchembio.2070  0.785
2016 Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. PMID 26972053 DOI: 10.1016/J.Cell.2016.02.035  0.583
2016 Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... ... Sabatini DM, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 531: 53-8. PMID 26935695 DOI: 10.1038/Nature17173  0.775
2016 Caron A, Labbé SM, Lanfray D, Blanchard PG, Villot R, Roy C, Sabatini DM, Richard D, Laplante M. Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity. Molecular Metabolism. 5: 102-12. PMID 26909318 DOI: 10.1016/J.Molmet.2015.11.005  0.763
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Sabatini DM, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.403
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Sabatini DM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.49
2016 Lewis CA, Fiske BP, Pacold ME, Hosios AM, Mattaini KR, Sabatini DM, Heiden MGV. Abstract PR10: Serine biosynthesis from glucose regulates folate availability Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-Pr10  0.408
2016 Sabatini DM. Abstract IA11: Systematic approaches to understanding cellular metabolism Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-Ia11  0.417
2015 Shaul YD, Yuan B, Thiru P, Nutter-Upham A, McCallum S, Lanzkron C, Bell GW, Sabatini DM. MERAV: a tool for comparing gene expression across human tissues and cell types. Nucleic Acids Research. PMID 26626150 DOI: 10.1093/nar/gkv1337  0.343
2015 Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S. Cooperative nutrient accumulation sustains growth of mammalian cells. Scientific Reports. 5: 17401. PMID 26620632 DOI: 10.1038/Srep17401  0.586
2015 Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science (New York, N.Y.). PMID 26586190 DOI: 10.1126/Science.Aad2087  0.718
2015 Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM. Identification and characterization of essential genes in the human genome. Science (New York, N.Y.). PMID 26472758 DOI: 10.1126/Science.Aac7041  0.649
2015 Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science (New York, N.Y.). PMID 26449471 DOI: 10.1126/Science.Aab2674  0.587
2015 Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL. Identification of an oncogenic RAB protein. Science (New York, N.Y.). 350: 211-7. PMID 26338797 DOI: 10.1126/Science.Aaa4903  0.4
2015 Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1. Cell Reports. 12: 1445-55. PMID 26299971 DOI: 10.1016/j.celrep.2015.07.052  0.4
2015 Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 162: 540-551. PMID 26232224 DOI: 10.1016/J.Cell.2015.07.016  0.806
2015 Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, ... ... Sabatini DM, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520: 363-7. PMID 25855294 DOI: 10.1038/Nature14363  0.8
2015 Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM. Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science (New York, N.Y.). 348: 340-3. PMID 25837514 DOI: 10.1126/Science.1260384  0.323
2015 Strohecker AM, Joshi S, Possemato R, Abraham RT, Sabatini DM, White E. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene. PMID 25772235 DOI: 10.1038/onc.2015.23  0.336
2015 Efeyan A, Comb WC, Sabatini DM. Nutrient-sensing mechanisms and pathways. Nature. 517: 302-10. PMID 25592535 DOI: 10.1038/nature14190  0.338
2015 Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, ... ... Sabatini DM, et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science (New York, N.Y.). 347: 188-94. PMID 25567906 DOI: 10.1126/Science.1257132  0.559
2015 Grabiner B, Wagle N, Allen EV, Garraway L, Lorch J, Sabatini D. Abstract PR04: mTOR mutations in cancer Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-Pr04  0.345
2015 Schweitzer LD, Sabatini DM. Abstract A22: Identification of a novel protein that blocks the Rag-Ragulator interaction and inhibits mTORC1 Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-A22  0.402
2015 Caron A, Labbé SM, Lanfray D, Blanchard PG, Villot R, Roy C, Sabatini DM, Richard D, Laplante M. Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity Molecular Metabolism. DOI: 10.1016/j.molmet.2015.11.005  0.695
2014 Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, ... ... Sabatini DM, et al. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Science Signaling. 7: ra121. PMID 25538079 DOI: 10.1126/Scisignal.Aaa1877  0.584
2014 Wagle N, Grabiner BC, Van Allen EM, Amin-Mansour A, Taylor-Weiner A, Rosenberg M, Gray N, Barletta JA, Guo Y, Swanson SJ, Ruan DT, Hanna GJ, Haddad RI, Getz G, Kwiatkowski DJ, ... ... Sabatini DM, et al. Response and acquired resistance to everolimus in anaplastic thyroid cancer. The New England Journal of Medicine. 371: 1426-33. PMID 25295501 DOI: 10.1056/Nejmoa1403352  0.47
2014 Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Reports. 9: 1-8. PMID 25263562 DOI: 10.1016/J.Celrep.2014.09.014  0.383
2014 Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, ... Sabatini DM, et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 158: 1094-109. PMID 25171410 DOI: 10.1016/J.Cell.2014.07.032  0.718
2014 Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell. 13: 911-7. PMID 25059582 DOI: 10.1111/Acel.12256  0.713
2014 Lee CC, Freinkman E, Sabatini DM, Ploegh HL. The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D. The Journal of Biological Chemistry. 289: 17124-31. PMID 24782309 DOI: 10.1074/Jbc.M114.571257  0.353
2014 Efeyan A, Schweitzer LD, Bilate AM, Chang S, Kirak O, Lamming DW, Sabatini DM. RagA, but not RagB, is essential for embryonic development and adult mice. Developmental Cell. 29: 321-9. PMID 24768164 DOI: 10.1016/J.Devcel.2014.03.017  0.637
2014 Festuccia WT, Pouliot P, Bakan I, Sabatini DM, Laplante M. Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. Plos One. 9: e95432. PMID 24740015 DOI: 10.1371/Journal.Pone.0095432  0.647
2014 Bar-Peled L, Sabatini DM. Regulation of mTORC1 by amino acids. Trends in Cell Biology. 24: 400-6. PMID 24698685 DOI: 10.1016/j.tcb.2014.03.003  0.374
2014 Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM. Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell Reports. 7: 27-34. PMID 24685140 DOI: 10.1016/J.Celrep.2014.02.046  0.653
2014 Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 508: 108-12. PMID 24670634 DOI: 10.1038/Nature13110  0.669
2014 Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discovery. 4: 554-63. PMID 24631838 DOI: 10.1158/2159-8290.CD-13-0929  0.704
2014 Mihaylova MM, Sabatini DM, Yilmaz ÖH. Dietary and metabolic control of stem cell function in physiology and cancer. Cell Stem Cell. 14: 292-305. PMID 24607404 DOI: 10.1016/J.Stem.2014.02.008  0.558
2014 Soliman MA, Abdel Rahman AM, Lamming DW, Lamming DA, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. Science Signaling. 7: ra17. PMID 24550542 DOI: 10.1126/Scisignal.2004785  0.773
2014 Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, ... ... Sabatini DM, et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Reports. 6: 313-24. PMID 24440720 DOI: 10.1016/J.Celrep.2013.12.032  0.691
2014 Wang T, Wei JJ, Sabatini DM, Lander ES. Genetic screens in human cells using the CRISPR-Cas9 system. Science (New York, N.Y.). 343: 80-4. PMID 24336569 DOI: 10.1126/science.1246981  0.323
2014 Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 300-15. PMID 24072782 DOI: 10.1096/Fj.13-237743  0.659
2014 Sabatini DM. Regulation of growth and metabolism Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-O20  0.428
2014 Wagle N, Grabiner BC, Allen EMV, Amin-Mansour A, Carter SC, Gray N, Barletta JA, Swanson SJ, Ruan D, Kwiatkowski DJ, Hanna GJ, Haddad RI, Sabatini D, Janne PA, Garraway LA, et al. Abstract 1724: Genomic mechanisms of exquisite sensitivity and acquired resistance to everolimus in a patient with anaplastic thyroid carcinoma Cancer Research. 74: 1724-1724. DOI: 10.1158/1538-7445.Am2014-1724  0.506
2014 Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. A correction to the research article titled: "The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism" (Science Signaling (2014)) Science Signaling. 7. DOI: 10.1126/scisignal.7315er2  0.626
2013 Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T. The TSC-mTOR pathway regulates macrophage polarization. Nature Communications. 4: 2834. PMID 24280772 DOI: 10.1038/Ncomms3834  0.628
2013 Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM. A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. Nature Cell Biology. 15: 1473-85. PMID 24185178 DOI: 10.1038/Ncb2865  0.378
2013 Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Molecular Cell. 52: 495-505. PMID 24095279 DOI: 10.1016/J.Molcel.2013.09.016  0.309
2013 Lamming DW, Sabatini DM. A Central role for mTOR in lipid homeostasis. Cell Metabolism. 18: 465-9. PMID 23973332 DOI: 10.1016/J.Cmet.2013.08.002  0.632
2013 Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA. Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging. 5: 539-50. PMID 23929887  0.569
2013 Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (New York, N.Y.). 341: 1236566. PMID 23888043 DOI: 10.1126/Science.1236566  0.745
2013 Efeyan A, Sabatini DM. Nutrients and growth factors in mTORC1 activation. Biochemical Society Transactions. 41: 902-5. PMID 23863153 DOI: 10.1042/BST20130063  0.34
2013 Sabatini D. An interview with David Sabatini Trends in Pharmacological Sciences. 34: 359-360. PMID 23763868 DOI: 10.1016/j.tips.2013.05.005  0.335
2013 Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, ... ... Sabatini DM, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 498: 246-50. PMID 23728299 DOI: 10.1038/Nature12147  0.745
2013 Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science (New York, N.Y.). 340: 1100-6. PMID 23723238 DOI: 10.1126/Science.1232044  0.422
2013 Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY. Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. Cancer Discovery. 3: 908-21. PMID 23719831 DOI: 10.1158/2159-8290.Cd-12-0507  0.568
2013 Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 12: 712-8. PMID 23648089 DOI: 10.1111/Acel.12097  0.6
2013 Laplante M, Sabatini DM. Regulation of mTORC1 and its impact on gene expression at a glance. Journal of Cell Science. 126: 1713-9. PMID 23641065 DOI: 10.1242/Jcs.125773  0.702
2013 Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell. 12: 645-51. PMID 23601134 DOI: 10.1111/Acel.12088  0.625
2013 Lamming DW, Ye L, Sabatini DM, Baur JA. Rapalogs and mTOR inhibitors as anti-aging therapeutics. The Journal of Clinical Investigation. 123: 980-9. PMID 23454761 DOI: 10.1172/Jci64099  0.609
2013 Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, ... ... Sabatini DM, et al. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Research. 73: 2574-86. PMID 23436801 DOI: 10.1158/0008-5472.Can-12-1702  0.524
2013 Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature. 493: 679-83. PMID 23263183 DOI: 10.1038/Nature11745  0.353
2013 Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics. 45: 104-8. PMID 23202129 DOI: 10.1038/Ng.2471  0.74
2013 Sabatini DM. Abstract SY01-01: Regulation of growth by the mTOR pathway. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy01-01  0.412
2013 Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon J, Jacks T, Sabatini DM, Kalaany NY. Abstract 4317: PTEN-null tumors cohabiting the same lung display differential Akt activation and sensitivity to dietary restriction. Cancer Research. 73: 4317-4317. DOI: 10.1158/1538-7445.Am2013-4317  0.566
2013 Grabiner B, Sabatini D. Abstract A163: A diverse array of mutations in MTOR are hyperactivating and correlate with rapamycin sensitivity. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A163  0.325
2012 Lamming DW, Sabatini DM, Baur JA. Pharmacologic Means of Extending Lifespan. Journal of Clinical & Experimental Pathology. PMID 25379357 DOI: 10.4172/2161-0681.S4-002  0.575
2012 Cantor JR, Sabatini DM. Cancer cell metabolism: one hallmark, many faces. Cancer Discovery. 2: 881-98. PMID 23009760 DOI: 10.1158/2159-8290.CD-12-0345  0.361
2012 Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 150: 1196-208. PMID 22980980 DOI: 10.1016/J.Cell.2012.07.032  0.327
2012 Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA. Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2. Frontiers in Genetics. 3: 177. PMID 22973301 DOI: 10.3389/Fgene.2012.00177  0.613
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Sabatini DM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.557
2012 Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM. DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metabolism. 16: 202-12. PMID 22883231 DOI: 10.1016/J.Cmet.2012.07.008  0.762
2012 Birsoy K, Sabatini DM, Possemato R. Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson. Nature Medicine. 18: 1022-3. PMID 22772555 DOI: 10.1038/Nm.2870  0.655
2012 Efeyan A, Zoncu R, Sabatini DM. Amino acids and mTORC1: from lysosomes to disease. Trends in Molecular Medicine. 18: 524-33. PMID 22749019 DOI: 10.1016/J.Molmed.2012.05.007  0.383
2012 Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, ... Sabatini DM, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 486: 490-5. PMID 22722868 DOI: 10.1038/Nature11163  0.758
2012 Wood KC, Konieczkowski DJ, Johannessen CM, Boehm JS, Tamayo P, Botvinnik OB, Mesirov JP, Hahn WC, Root DE, Garraway LA, Sabatini DM. MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. Science Signaling. 5: rs4. PMID 22589389 DOI: 10.1126/Scisignal.2002612  0.593
2012 Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metabolism. 15: 713-24. PMID 22560223 DOI: 10.1016/J.Cmet.2012.04.007  0.651
2012 Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 485: 109-13. PMID 22552098 DOI: 10.1038/Nature11083  0.483
2012 Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 149: 274-93. PMID 22500797 DOI: 10.1016/J.Cell.2012.03.017  0.674
2012 Liu Q, Ren T, Fresques T, Oppliger W, Niles BJ, Hur W, Sabatini DM, Hall MN, Powers T, Gray NS. Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae. Acs Chemical Biology. 7: 982-7. PMID 22496512 DOI: 10.1021/Cb300058V  0.542
2012 Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (New York, N.Y.). 335: 1638-43. PMID 22461615 DOI: 10.1126/Science.1215135  0.614
2012 Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. The Embo Journal. 31: 1095-108. PMID 22343943 DOI: 10.1038/Emboj.2012.32  0.401
2012 Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, ... ... Sabatini DM, et al. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. The Journal of Biological Chemistry. 287: 9742-52. PMID 22223645 DOI: 10.1074/Jbc.M111.304485  0.504
2012 Laplante M, Sabatini DM. mTOR Signaling. Cold Spring Harbor Perspectives in Biology. 4. PMID 22129599 DOI: 10.1101/cshperspect.a011593  0.601
2012 Liu Q, Kang SA, Thoreen CC, Hur W, Wang J, Chang JW, Markhard A, Zhang J, Sim T, Sabatini DM, Gray NS. Development of ATP-competitive mTOR inhibitors. Methods in Molecular Biology (Clifton, N.J.). 821: 447-60. PMID 22125084 DOI: 10.1007/978-1-61779-430-8_29  0.537
2012 Sabatini DM. Growth control and metabolism Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O22  0.426
2011 Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (New York, N.Y.). 334: 678-83. PMID 22053050 DOI: 10.1126/Science.1207056  0.333
2011 Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metabolism. 14: 516-27. PMID 21982711 DOI: 10.1016/J.Cmet.2011.09.001  0.379
2011 Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 146: 408-20. PMID 21816276 DOI: 10.1016/J.Cell.2011.06.034  0.625
2011 Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, ... ... Sabatini DM, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476: 346-50. PMID 21760589 DOI: 10.1038/Nature10350  0.793
2011 Reiling JH, Clish CB, Carette JE, Varadarajan M, Brummelkamp TR, Sabatini DM. A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin. Proceedings of the National Academy of Sciences of the United States of America. 108: 11756-65. PMID 21677192 DOI: 10.1073/pnas.1018098108  0.358
2011 Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (New York, N.Y.). 332: 1317-22. PMID 21659604 DOI: 10.1126/Science.1199498  0.546
2011 Lamming DW, Sabatini DM. A radical role for TOR in longevity. Cell Metabolism. 13: 617-8. PMID 21641542 DOI: 10.1016/J.Cmet.2011.05.006  0.627
2011 Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Choi HG, Waller DL, Sim T, Sabatini DM, Gray NS. Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability. Bioorganic & Medicinal Chemistry Letters. 21: 4036-40. PMID 21621413 DOI: 10.1016/J.Bmcl.2011.04.129  0.439
2011 Zoncu R, Sabatini DM. Cell biology. The TASCC of secretion. Science (New York, N.Y.). 332: 923-5. PMID 21596981 DOI: 10.1126/Science.1207552  0.391
2011 Sheen JH, Zoncu R, Kim D, Sabatini DM. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell. 19: 613-28. PMID 21575862 DOI: 10.1016/J.Ccr.2011.03.012  0.37
2011 Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. Journal of Medicinal Chemistry. 54: 1473-80. PMID 21322566 DOI: 10.1021/Jm101520V  0.5
2011 Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, Ali SM, Sengupta S, Shaul YD, Lamprecht MR, Madden KL, Papallo AR, Jones TR, Sabatini DM, Carpenter AE. Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. Genome Research. 21: 433-46. PMID 21239477 DOI: 10.1101/Gr.111492.110  0.631
2011 Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Reviews. Molecular Cell Biology. 12: 21-35. PMID 21157483 DOI: 10.1038/Nrm3025  0.378
2011 Sabatini DM, VanHook AM. Science Signaling Podcast: 8 November 2011 Science Signaling. 4: pc24-pc24. DOI: 10.1126/Scisignal.2002580  0.363
2010 Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature. 468: 1100-4. PMID 21179166 DOI: 10.1038/Nature09584  0.68
2010 Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Molecular Cell. 40: 310-22. PMID 20965424 DOI: 10.1016/j.molcel.2010.09.026  0.361
2010 Liu Q, Chang JW, Wang J, Kang SA, Thoreen CC, Markhard A, Hur W, Zhang J, Sim T, Sabatini DM, Gray NS. Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. Journal of Medicinal Chemistry. 53: 7146-55. PMID 20860370 DOI: 10.1021/Jm101144F  0.519
2010 Yip CK, Murata K, Walz T, Sabatini DM, Kang SA. Structure of the human mTOR complex I and its implications for rapamycin inhibition. Molecular Cell. 38: 768-74. PMID 20542007 DOI: 10.1016/J.Molcel.2010.05.017  0.381
2010 DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, ... ... Sabatini DM, et al. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Research. 20: 1133-42. PMID 20508142 DOI: 10.1101/Gr.106773.110  0.323
2010 Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Molecular Cancer Research : McR. 8: 896-906. PMID 20501647 DOI: 10.1158/1541-7786.Mcr-09-0409  0.387
2010 Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 141: 290-303. PMID 20381137 DOI: 10.1016/J.Cell.2010.02.024  0.333
2010 Laplante M, Sabatini DM. mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 3281-2. PMID 20167806 DOI: 10.1073/Pnas.1000323107  0.63
2010 Efeyan A, Sabatini DM. mTOR and cancer: many loops in one pathway. Current Opinion in Cell Biology. 22: 169-76. PMID 19945836 DOI: 10.1016/j.ceb.2009.10.007  0.368
2010 Lamming DW, Sabatini DM. Regulation of TOR signaling in mammals Enzymes. 27: 21-38. DOI: 10.1016/S1874-6047(10)27002-6  0.67
2009 Liu Q, Thoreen C, Wang J, Sabatini D, Gray NS. mTOR Mediated Anti-Cancer Drug Discovery. Drug Discovery Today. Therapeutic Strategies. 6: 47-55. PMID 20622997 DOI: 10.1016/J.Ddstr.2009.12.001  0.572
2009 Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Current Biology : Cb. 19: R1046-52. PMID 19948145 DOI: 10.1016/J.Cub.2009.09.058  0.661
2009 Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, ... ... Sabatini DM, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 462: 108-12. PMID 19847166 DOI: 10.1038/Nature08460  0.384
2009 Laplante M, Sabatini DM. mTOR signaling at a glance. Journal of Cell Science. 122: 3589-94. PMID 19812304 DOI: 10.1242/Jcs.051011  0.683
2009 Wood KC, Sabatini DM. Growth signaling at the nexus of stem cell life and death. Cell Stem Cell. 5: 232-4. PMID 19733530 DOI: 10.1016/j.stem.2009.08.008  0.542
2009 Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 137: 873-86. PMID 19446321 DOI: 10.1016/J.Cell.2009.03.046  0.74
2009 Thoreen CC, Sabatini DM. Rapamycin inhibits mTORC1, but not completely. Autophagy. 5: 725-6. PMID 19395872 DOI: 10.4161/auto.5.5.8504  0.363
2009 Guertin DA, Sabatini DM. The pharmacology of mTOR inhibition. Science Signaling. 2: pe24. PMID 19383975 DOI: 10.1126/scisignal.267pe24  0.33
2009 Kalaany NY, Sabatini DM. Tumours with PI3K activation are resistant to dietary restriction. Nature. 458: 725-31. PMID 19279572 DOI: 10.1038/nature07782  0.362
2009 Jones TR, Carpenter AE, Lamprecht MR, Moffat J, Silver SJ, Grenier JK, Castoreno AB, Eggert US, Root DE, Golland P, Sabatini DM. Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proceedings of the National Academy of Sciences of the United States of America. 106: 1826-31. PMID 19188593 DOI: 10.1073/Pnas.0808843106  0.549
2009 Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 15: 148-59. PMID 19185849 DOI: 10.1016/J.Ccr.2008.12.017  0.305
2009 Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. The Journal of Biological Chemistry. 284: 8023-32. PMID 19150980 DOI: 10.1074/Jbc.M900301200  0.532
2009 Sancak Y, Sabatini DM. Rag proteins regulate amino-acid-induced mTORC1 signalling. Biochemical Society Transactions. 37: 289-90. PMID 19143648 DOI: 10.1042/BST0370289  0.392
2009 Liu Q, Thoreen C, Wang J, Sabatini D, Gray NS. MTOR mediated anti-cancer drug discovery Drug Discovery Today: Therapeutic Strategies. 6: 47-55. DOI: 10.1016/j.ddstr.2009.12.001  0.355
2008 Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, ... ... Sabatini DM, et al. Highly parallel identification of essential genes in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 20380-5. PMID 19091943 DOI: 10.1073/Pnas.0810485105  0.35
2008 Jones TR, Kang IH, Wheeler DB, Lindquist RA, Papallo A, Sabatini DM, Golland P, Carpenter AE. CellProfiler Analyst: data exploration and analysis software for complex image-based screens. Bmc Bioinformatics. 9: 482. PMID 19014601 DOI: 10.1186/1471-2105-9-482  0.539
2008 Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell. 134: 703-7. PMID 18775299 DOI: 10.1016/j.cell.2008.08.021  0.34
2008 Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (New York, N.Y.). 320: 1496-501. PMID 18497260 DOI: 10.1126/science.1157535  0.359
2008 Reiling JH, Sabatini DM. Increased mTORC1 signaling UPRegulates stress. Molecular Cell. 29: 533-5. PMID 18342598 DOI: 10.1016/j.molcel.2008.02.011  0.307
2008 Floyd S, Pacold M, Blake E, Sabatini D, Yaffe M. A High Throughput Automated Microscopy RNAi Screen for Modifiers of the DNA Damage Response to Ionizing Radiation International Journal of Radiation Oncology*Biology*Physics. 72: S692-S693. DOI: 10.1016/J.Ijrobp.2008.06.588  0.647
2007 Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 12: 9-22. PMID 17613433 DOI: 10.1016/j.ccr.2007.05.008  0.353
2007 Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Molecular Cell. 25: 903-15. PMID 17386266 DOI: 10.1016/j.molcel.2007.03.003  0.378
2007 Lamprecht MR, Sabatini DM, Carpenter AE. CellProfiler: free, versatile software for automated biological image analysis. Biotechniques. 42: 71-5. PMID 17269487 DOI: 10.2144/000112257  0.522
2007 Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C, Giles FJ, Sabatini DM, Andreeff M, Konopleva M. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood. 109: 3509-12. PMID 17179228 DOI: 10.1182/Blood-2006-06-030833  0.392
2006 Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Developmental Cell. 11: 859-71. PMID 17141160 DOI: 10.1016/J.Devcel.2006.10.007  0.369
2006 Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biology. 7: R100. PMID 17076895 DOI: 10.1186/Gb-2006-7-10-R100  0.576
2006 Reiling JH, Sabatini DM. Stress and mTORture signaling. Oncogene. 25: 6373-83. PMID 17041623 DOI: 10.1038/sj.onc.1209889  0.334
2006 Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Current Biology : Cb. 16: 1865-70. PMID 16919458 DOI: 10.1016/j.cub.2006.08.001  0.396
2006 Sabatini DM. mTOR and cancer: insights into a complex relationship. Nature Reviews. Cancer. 6: 729-34. PMID 16915295 DOI: 10.1038/nrc1974  0.362
2006 Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM. Functional genomics identifies TOR-regulated genes that control growth and division. Current Biology : Cb. 16: 958-70. PMID 16713952 DOI: 10.1016/j.cub.2006.03.084  0.375
2006 Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Molecular Cell. 22: 159-68. PMID 16603397 DOI: 10.1016/j.molcel.2006.03.029  0.399
2006 Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, ... ... Sabatini DM, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/J.Cell.2006.01.040  0.579
2006 Moffat J, Sabatini DM. Building mammalian signalling pathways with RNAi screens Nature Reviews Molecular Cell Biology. 7: 177-187. PMID 16496020 DOI: 10.1038/Nrm1860  0.316
2006 Bailey SN, Ali SM, Carpenter AE, Higgins CO, Sabatini DM. Microarrays of lentiviruses for gene function screens in immortalized and primary cells. Nature Methods. 3: 117-22. PMID 16432521 DOI: 10.1038/Nmeth848  0.571
2006 Zeng Z, Sarbassov DD, Giles FJ, Samudio I, Yee KW, Jackson CE, Sabatini DM, Andreeff M, Konopleva M. Rapamycin Analogs Reduce mTORC2 Signaling and Inhibit AKT Activation in AML. Blood. 108: 156-156. DOI: 10.1182/Blood.V108.11.156.156  0.344
2006 Sabatini DM. Role of the mTOR Signaling Pathway in Disease Inflammatory Bowel Diseases. 12: S9. DOI: 10.1097/00054725-200604002-00019  0.305
2005 Peterson TR, Sabatini DM. eIF3: A connecTOR of S6K1 to the translation preinitiation complex Molecular Cell. 20: 655-657. PMID 16337588 DOI: 10.1016/j.molcel.2005.11.016  0.346
2005 Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway Current Opinion in Cell Biology. 17: 596-603. PMID 16226444 DOI: 10.1016/j.ceb.2005.09.009  0.416
2005 Sarbassov DD, Sabatini DM. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex Journal of Biological Chemistry. 280: 39505-39509. PMID 16183647 DOI: 10.1074/jbc.M506096200  0.4
2005 Thoreen CC, Sabatini DM. AMPK and p53 help cells through lean times Cell Metabolism. 1: 287-288. PMID 16054073 DOI: 10.1016/j.cmet.2005.04.009  0.32
2005 Guertin DA, Sabatini DM. An expanding role for mTOR in cancer Trends in Molecular Medicine. 11: 353-361. PMID 16002336 DOI: 10.1016/j.molmed.2005.06.007  0.41
2005 Wheeler DB, Carpenter AE, Sabatini DM. Cell microarrays and RNA interference chip away at gene function. Nature Genetics. 37: S25-30. PMID 15920526 DOI: 10.1038/Ng1560  0.567
2005 Ali SM, Sabatini DM. Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site Journal of Biological Chemistry. 280: 19445-19448. PMID 15809305 DOI: 10.1074/jbc.C500125200  0.35
2004 Wheeler DB, Bailey SN, Guertin DA, Carpenter AE, Higgins CO, Sabatini DM. RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells. Nature Methods. 1: 127-32. PMID 15782175 DOI: 10.1038/Nmeth711  0.593
2004 Dos DS, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton Current Biology. 14: 1296-1302. PMID 15268862 DOI: 10.1016/J.Cub.2004.06.054  0.404
2004 Thoreen CC, Sabatini DM. Huntingtin aggregates ask to be eaten Nature Genetics. 36: 553-554. PMID 15167929 DOI: 10.1038/ng0604-553  0.305
2004 Carpenter AE, Sabatini DM. Systematic genome-wide screens of gene function. Nature Reviews. Genetics. 5: 11-22. PMID 14708012 DOI: 10.1038/Nrg1248  0.551
2004 Guertin DA, Kim D, Sabatini DM. 7 Growth Control through the mTOR Network Cold Spring Harbor Monograph Archive. 42: 193-234. DOI: 10.1101/087969672.42.193  0.341
2003 Kim DH, Sabatini DM. Raptor and mTOR: Subunits of a nutrient-sensitive complex Current Topics in Microbiology and Immunology. 279: 259-270. PMID 14560962 DOI: 10.1007/978-3-642-18930-2_15  0.426
2003 Schalm SS, Fingar DC, Sabatini DM, Blenis J. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Current Biology : Cb. 13: 797-806. PMID 12747827 DOI: 10.1016/S0960-9822(03)00329-4  0.353
2003 Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KVP, Erdjument-Bromage H, Tempst P, Sabatini DM. GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR Molecular Cell. 11: 895-904. PMID 12718876 DOI: 10.1016/S1097-2765(03)00114-X  0.415
2003 Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells. Rna (New York, N.Y.). 9: 493-501. PMID 12649500 DOI: 10.1261/Rna.2192803  0.307
2002 Bailey SN, Wu RZ, Sabatini DM. Applications of transfected cell microarrays in high-throughput drug discovery Drug Discovery Today. 7: S113-S118. PMID 12546876 DOI: 10.1016/S1359-6446(02)02386-3  0.322
2002 Wu RZ, Bailey SN, Sabatini DM. Cell-biological applications of transfected-cell microarrays Trends in Cell Biology. 12: 485-488. PMID 12441253 DOI: 10.1016/S0962-8924(02)02354-1  0.335
2002 Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 110: 163-75. PMID 12150925 DOI: 10.1016/S0092-8674(02)00808-5  0.436
2002 Peng T, Golub TR, Sabatini DM. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Molecular and Cellular Biology. 22: 5575-84. PMID 12101249 DOI: 10.1128/MCB.22.15.5575-5584.2002  0.389
2002 Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Molecular and Cellular Biology. 22: 2111-23. PMID 11884599 DOI: 10.1128/Mcb.22.7.2111-2123.2002  0.344
2001 Hentges KE, Sirry B, Gingeras AC, Sarbassov D, Sonenberg N, Sabatini D, Peterson AS. FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 98: 13796-801. PMID 11707573 DOI: 10.1073/Pnas.241184198  0.38
2001 Ziauddin J, Sabatini DM. Microarrays of cells expressing defined cDNAs Nature. 411: 107-110. PMID 11333987 DOI: 10.1038/35075114  0.327
2000 Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. The Journal of Biological Chemistry. 275: 10779-87. PMID 10753870 DOI: 10.1074/Jbc.275.15.10779  0.348
2000 Kumar V, Pandey P, Sabatini D, Kumar M, Majumder PK, Bharti A, Carmichael G, Kufe D, Kharbanda S. Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation. The Embo Journal. 19: 1087-97. PMID 10698949 DOI: 10.1093/Emboj/19.5.1087  0.32
1999 Sabatini DM, Barrow RK, Blackshaw S, Burnett PE, Lai MM, Field ME, Bahr BA, Kirsch J, Betz H, Snyder SH. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science (New York, N.Y.). 284: 1161-4. PMID 10325225 DOI: 10.1126/Science.284.5417.1161  0.799
1998 Walensky LD, Dawson TM, Steiner JP, Sabatini DM, Suarez JD, Klinefelter GR, Snyder SH. The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. Molecular Medicine (Cambridge, Mass.). 4: 502-14. PMID 9742506  0.609
1998 Burnett PE, Blackshaw S, Lai MM, Qureshi IA, Burnett AF, Sabatini DM, Snyder SH. Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America. 95: 8351-6. PMID 9653190 DOI: 10.1073/Pnas.95.14.8351  0.782
1998 Snyder SH, Sabatini DM, Lai MM, Steiner JP, Hamilton GS, Suzdak PD. Neural actions of immunophilin ligands. Trends in Pharmacological Sciences. 19: 21-6. PMID 9509898 DOI: 10.1016/S0165-6147(97)01146-2  0.412
1998 Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proceedings of the National Academy of Sciences of the United States of America. 95: 1432-7. PMID 9465032 DOI: 10.1073/Pnas.95.4.1432  0.752
1998 Walensky LD, Dawson TM, Steiner JP, Sabatini DM, Suarez JD, Klinefelter GR, Snyder SH. The 12 kD FK506 Binding Protein FKBP12 Is Released in the Male Reproductive Tract and Stimulates Sperm Motility Molecular Medicine. 4: 502-514. DOI: 10.1007/Bf03401755  0.675
1997 Sabatini DM, Lai MM, Snyder SH. Neural roles of immunophilins and their ligands. Molecular Neurobiology. 15: 223-39. PMID 9396011 DOI: 10.1007/BF02740635  0.44
1996 Khan AA, Soloski MJ, Sharp AH, Schilling G, Sabatini DM, Li SH, Ross CA, Snyder SH. Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. Science (New York, N.Y.). 273: 503-7. PMID 8662540 DOI: 10.1126/Science.273.5274.503  0.535
1995 Sabatini DM, Pierchala BA, Barrow RK, Schell MJ, Snyder SH. The rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity. The Journal of Biological Chemistry. 270: 20875-8. PMID 7673106 DOI: 10.1074/Jbc.270.36.20875  0.628
1995 Snyder SH, Sabatini DM. Immunophilins and the nervous system. Nature Medicine. 1: 32-7. PMID 7584950 DOI: 10.1038/nm0195-32  0.404
1995 Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH. Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Proceedings of the National Academy of Sciences of the United States of America. 92: 1784-8. PMID 7533300 DOI: 10.1073/Pnas.92.5.1784  0.609
1994 Erdjument-Bromage H, Lui M, Sabatini DM, Snyder SH, Tempst P. High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target. Protein Science : a Publication of the Protein Society. 3: 2435-46. PMID 7756997 DOI: 10.1002/pro.5560031227  0.409
1994 Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell. 78: 35-43. PMID 7518356 DOI: 10.1016/0092-8674(94)90570-3  0.464
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