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Zamaneh Kassiri, Ph.D. - Publications

Affiliations: 
2002 University of Toronto, Toronto, ON, Canada 
Area:
Animal Physiology Biology, Cell Biology
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Aujla PK, Hu M, Hartley B, Kranrod J, Viveiros A, Kilic T, Owen CA, Oudit GY, Seubert JM, Julien O, Kassiri Z. Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway. Hypertension (Dallas, Tex. : 1979). PMID 36330793 DOI: 10.1161/HYPERTENSIONAHA.122.19411  0.316
2022 Nagalingam RS, Chattopadhyaya S, Al-Hattab DS, Cheung DYC, Schwartz LY, Jana S, Aroutiounova N, Ledingham DA, Moffatt TL, Landry NM, Bagchi RA, Dixon IMC, Wigle JT, Oudit GY, Kassiri Z, et al. Scleraxis and fibrosis in the pressure-overloaded heart. European Heart Journal. PMID 36200607 DOI: 10.1093/eurheartj/ehac362  0.309
2022 Chute M, Aujla PK, Li Y, Jana S, Zhabyeyev P, Rasmuson J, Owen CA, Abraham T, Oudit GY, Kassiri Z. ADAM15 is required for optimal collagen cross-linking and scar formation following myocardial infarction. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 34995785 DOI: 10.1016/j.matbio.2021.12.002  0.314
2021 Fan D, Kassiri Z. Modulation of Cardiac Fibrosis in and Beyond Cells. Frontiers in Molecular Biosciences. 8: 750626. PMID 34778374 DOI: 10.3389/fmolb.2021.750626  0.324
2021 Jana S, Aujla P, Hu M, Kilic T, Zhabyeyev P, McCulloch CA, Oudit GY, Kassiri Z. Gelsolin is an important mediator of Angiotensin II-induced activation of cardiac fibroblasts and fibrosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21932. PMID 34549830 DOI: 10.1096/fj.202100038RR  0.326
2020 Oh Y, Yang S, Liu X, Jana S, Izaddoustdar F, Gao X, Debi R, Kim DK, Kim KH, Yang P, Kassiri Z, Lakin R, Backx PH. Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised Mice. Frontiers in Physiology. 11: 605671. PMID 33424629 DOI: 10.3389/fphys.2020.605671  0.685
2018 Patel VB, Zhabyeyev P, Chen X, Wang F, Paul M, Fan D, McLean BA, Basu R, Zhang P, Shah S, Dawson JF, Pyle WG, Hazra M, Kassiri Z, Hazra S, et al. PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease. Nature Communications. 9: 5390. PMID 30568254 DOI: 10.1038/s41467-018-07812-8  0.313
2018 Chen X, Zhabyeyev P, Azad AK, Wang W, Minerath RA, DesAulniers J, Grueter CE, Murray AG, Kassiri Z, Vanhaesebroeck B, Oudit GY. Endothelial and Cardiomyocyte PI3Kβ Divergently Regulate Cardiac Remodeling in Response to Ischemic Injury. Cardiovascular Research. PMID 30496354 DOI: 10.1093/Cvr/Cvy298  0.313
2014 Wang W, Patel VB, Parajuli N, Fan D, Basu R, Wang Z, Ramprasath T, Kassiri Z, Penninger JM, Oudit GY. Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease. Journal of Molecular Medicine (Berlin, Germany). 92: 847-58. PMID 24728465 DOI: 10.1007/S00109-014-1149-Y  0.304
2014 Fan D, Takawale A, Basu R, Patel V, Lee J, Kandalam V, Wang X, Oudit GY, Kassiri Z. Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction. Cardiovascular Research. 103: 268-80. PMID 24692173 DOI: 10.1093/cvr/cvu072  0.328
2013 Wang W, Patel V, Wang Z, Kassiri Z, Penninger J, Oudit G. Haploinsufficiency of ACE2 Is Sufficient to Enhance Susceptibility to Heart Failure With Adverse Cardiovascular Remodeling Canadian Journal of Cardiology. 29: S234-S235. DOI: 10.1016/J.Cjca.2013.07.378  0.367
2012 Fan D, Takawale A, Lee J, Kassiri Z. Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenesis & Tissue Repair. 5: 15. PMID 22943504 DOI: 10.1186/1755-1536-5-15  0.313
2011 Guo D, Thiyam G, Bodiga S, Kassiri Z, Oudit GY. Uncoupling between enhanced excitation-contraction coupling and the response to heart disease: lessons from the PI3Kγ knockout murine model. Journal of Molecular and Cellular Cardiology. 50: 606-12. PMID 21276799 DOI: 10.1016/j.yjmcc.2011.01.011  0.332
2011 Bodiga S, JiuChang Z, Wang W, Basu R, Das S, Kassiri Z, Oudit G. 545 Cardioprotective effects mediated by AT1 receptor blockade and enhancing ang 1-7 in experimental heart failure in ACE2-null mice Canadian Journal of Cardiology. 27: S258-S259. DOI: 10.1016/J.Cjca.2011.07.453  0.372
2011 Mori J, Basu R, Zhang L, Wagg C, Kassiri Z, Lopaschuk G, Oudit G. 291 Angiotensin II induces diastolic dysfunction via the AT1 receptor with a reduction in carbohydrate oxidation caused by up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) Canadian Journal of Cardiology. 27: S168-S169. DOI: 10.1016/J.Cjca.2011.07.219  0.306
2010 Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY. Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circulation Research. 107: 1275-89. PMID 20847309 DOI: 10.1161/Circresaha.110.229054  0.624
2010 Kandalam V, Basu R, Abraham T, Wang X, Awad A, Wang W, Lopaschuk GD, Maeda N, Oudit GY, Kassiri Z. Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction. American Journal of Physiology. Heart and Circulatory Physiology. 299: H1012-23. PMID 20675565 DOI: 10.1152/Ajpheart.00246.2010  0.309
2010 Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R. Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload. The Journal of Biological Chemistry. 285: 24487-93. PMID 20516072 DOI: 10.1074/Jbc.M110.136820  0.312
2009 Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z. Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. American Journal of Physiology. Heart and Circulatory Physiology. 297: H2096-108. PMID 19801494 DOI: 10.1152/ajpheart.00452.2009  0.331
2009 Kassiri Z, Defamie V, Hariri M, Oudit GY, Anthwal S, Dawood F, Liu P, Khokha R. Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart. The Journal of Biological Chemistry. 284: 29893-904. PMID 19625257 DOI: 10.1074/Jbc.M109.028449  0.399
2009 Wang X, Oka T, Chow FL, Cooper SB, Odenbach J, Lopaschuk GD, Kassiri Z, Fernandez-Patron C. Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis. Hypertension. 54: 575-82. PMID 19581512 DOI: 10.1161/Hypertensionaha.108.127670  0.309
2008 Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM. Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovascular Research. 78: 505-14. PMID 18281373 DOI: 10.1093/Cvr/Cvn041  0.522
2007 Oudit GY, Kassiri Z. Role of PI3 kinase gamma in excitation-contraction coupling and heart disease. Cardiovascular & Hematological Disorders Drug Targets. 7: 295-304. PMID 18220729  0.306
2007 Wong DW, Oudit GY, Reich H, Kassiri Z, Zhou J, Liu QC, Backx PH, Penninger JM, Herzenberg AM, Scholey JW. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. The American Journal of Pathology. 171: 438-51. PMID 17600118 DOI: 10.2353/Ajpath.2007.060977  0.525
2007 Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovascular Research. 75: 29-39. PMID 17499227 DOI: 10.1016/J.Cardiores.2007.04.007  0.589
2006 Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW. Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. The American Journal of Pathology. 168: 1808-20. PMID 16723697 DOI: 10.2353/Ajpath.2006.051091  0.546
2006 Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R. Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. Journal of Immunology (Baltimore, Md. : 1950). 176: 721-5. PMID 16393953 DOI: 10.4049/Jimmunol.176.2.721  0.301
2006 Oudit G, Herzenberg A, Kassiri Z, Wong D, Reich H, Khokha R, Crackower M, Backx P, Penninger J, Scholey J. Angiotensin-Converting Enzyme-2 (ACE2)—A New Player in the Genesis of Glomerular Injury? Journal of the American Society of Nephrology. 17: 2637-2643. DOI: 10.1681/Asn.2006080888  0.434
2005 Joza N, Oudit GY, Brown D, Bénit P, Kassiri Z, Vahsen N, Benoit L, Patel MM, Nowikovsky K, Vassault A, Backx PH, Wada T, Kroemer G, Rustin P, Penninger JM. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Molecular and Cellular Biology. 25: 10261-72. PMID 16287843 DOI: 10.1128/Mcb.25.23.10261-10272.2005  0.524
2005 Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circulation Research. 97: 380-90. PMID 16037568 DOI: 10.1161/01.Res.0000178789.16929.Cf  0.575
2005 Kassiri Z, Khokha R. Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors. Thrombosis and Haemostasis. 93: 212-9. PMID 15711735 DOI: 10.1160/Th04-08-0522  0.419
2005 Ricci R, Eriksson U, Oudit GY, Eferl R, Akhmedov A, Sumara I, Sumara G, Kassiri Z, David JP, Bakiri L, Sasse B, Idarraga MH, Rath M, Kurz D, Theussl HC, et al. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes & Development. 19: 208-13. PMID 15655111 DOI: 10.1101/Gad.327005  0.56
2004 Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R. TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation. 110: 2401-9. PMID 15262835 DOI: 10.1161/01.Cir.0000134959.83967.2D  0.419
2002 Zobel C, Kassiri Z, Nguyen TT, Meng Y, Backx PH. Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes. Circulation. 106: 2385-91. PMID 12403671 DOI: 10.1161/01.Cir.0000033970.22130.93  0.565
2002 Kassiri Z, Hajjar R, Backx PH. Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes. Journal of Molecular Medicine (Berlin, Germany). 80: 351-8. PMID 12072910 DOI: 10.1007/S00109-002-0325-7  0.52
2002 Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, Backx PH. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circulation Research. 90: 578-85. PMID 11909822 DOI: 10.1161/01.Res.0000012223.86441.A1  0.557
2001 Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH. The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. Journal of Molecular and Cellular Cardiology. 33: 851-72. PMID 11343410 DOI: 10.1006/Jmcc.2001.1376  0.722
2000 Kassiri Z, Myers R, Kaprielian R, Banijamali HS, Backx PH. Rate-dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system. The Journal of Physiology. 524: 221-31. PMID 10747194 DOI: 10.1111/J.1469-7793.2000.T01-3-00221.X  0.702
1999 Kaprielian R, Wickenden AD, Kassiri Z, Parker TG, Liu PP, Backx PH. Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction. The Journal of Physiology. 517: 229-45. PMID 10226162 DOI: 10.1111/J.1469-7793.1999.0229Z.X  0.726
1998 Wickenden AD, Kaprielian R, Kassiri Z, Tsoporis JN, Tsushima R, Fishman GI, Backx PH. The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure. Cardiovascular Research. 37: 312-23. PMID 9614488 DOI: 10.1016/S0008-6363(97)00256-3  0.723
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