| Year |
Citation |
Score |
| 2021 |
Öztürk BE, Johnson ME, Kleyman M, Turunç S, He J, Jabalameli S, Xi Z, Visel M, Dufour VL, Iwabe S, Pompeo Marinho F, Aguirre GD, Sahel JA, Schaffer DV, Pfenning AR, et al. scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. Elife. 10. PMID 34664552 DOI: 10.7554/eLife.64175 |
0.59 |
|
| 2020 |
Muckom RJ, Sampayo RG, Johnson HJ, Schaffer DV. Advanced Materials to Enhance Central Nervous System Tissue Modeling and Cell Therapy. Advanced Functional Materials. 30. PMID 33510596 DOI: 10.1002/Adfm.202002931 |
0.41 |
|
| 2020 |
Muckom R, Bao X, Tran E, Chen E, Murugappan A, Dordick JS, Clark DS, Schaffer DV. High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates. Science Advances. 6: eaaz1457. PMID 32821815 DOI: 10.1126/Sciadv.Aaz1457 |
0.394 |
|
| 2020 |
Carneiro A, Lee HC, Lin L, van Haasteren J, Schaffer D. Novel lung tropic AAV capsids for therapeutic gene delivery. Human Gene Therapy. PMID 32799685 DOI: 10.1089/Hum.2020.169 |
0.338 |
|
| 2020 |
van Haasteren J, Li J, Scheideler OJ, Murthy N, Schaffer DV. The delivery challenge: fulfilling the promise of therapeutic genome editing. Nature Biotechnology. PMID 32601435 DOI: 10.1038/S41587-020-0565-5 |
0.351 |
|
| 2020 |
Repina NA, McClave T, Johnson HJ, Bao X, Kane RS, Schaffer DV. Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics. Cell Reports. 31: 107737. PMID 32521262 DOI: 10.1016/J.Celrep.2020.107737 |
0.322 |
|
| 2020 |
Tou CJ, Schaffer DV, Dueber JE. Targeted diversification in the genome with CRISPR-guided DNA polymerase I. Acs Synthetic Biology. PMID 32485105 DOI: 10.1021/Acssynbio.0C00149 |
0.32 |
|
| 2020 |
Byrne LC, Day TP, Visel M, Fortuny C, Dalkara D, Merigan WH, Schaffer DV, Flannery JG. In vivo directed evolution of AAV in the primate retina. Jci Insight. PMID 32271719 DOI: 10.1172/Jci.Insight.135112 |
0.753 |
|
| 2020 |
Scheideler OJ, Yang C, Kozminsky M, Mosher KI, Falcón-Banchs R, Ciminelli EC, Bremer AW, Chern SA, Schaffer DV, Sohn LL. Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach. Science Advances. 6: eaay5696. PMID 32206713 DOI: 10.1126/Sciadv.Aay5696 |
0.336 |
|
| 2020 |
Kang PH, Schaffer DV, Kumar S. Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells. Molecular Biology of the Cell. mbcE19110602. PMID 31940260 DOI: 10.1091/Mbc.E19-11-0602 |
0.385 |
|
| 2019 |
Kim SH, Lee S, Lee H, Cho M, Schaffer DV, Jang JH. AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems. Molecular Therapy. Nucleic Acids. 18: 432-443. PMID 31670142 DOI: 10.1016/J.Omtn.2019.09.015 |
0.395 |
|
| 2019 |
Bao X, Adil MM, Muckom R, Zimmermann JA, Tran A, Suhy N, Xu Y, Sampayo RG, Clark DS, Schaffer DV. Gene Editing to Generate Versatile Human Pluripotent Stem Cell Reporter Lines for Analysis of Differentiation and Lineage Tracing. Stem Cells (Dayton, Ohio). PMID 31634414 DOI: 10.1002/Stem.3096 |
0.422 |
|
| 2019 |
Ekman FK, Ojala DS, Adil MM, Lopez PA, Schaffer DV, Gaj T. CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model. Molecular Therapy. Nucleic Acids. 17: 829-839. PMID 31465962 DOI: 10.1016/J.Omtn.2019.07.009 |
0.357 |
|
| 2019 |
Qiao EL, Kumar S, Schaffer DV. Mastering their own fates through the matrix. Nature Materials. 18: 779-780. PMID 31332317 DOI: 10.1038/S41563-019-0429-X |
0.385 |
|
| 2019 |
Chen S, Sun S, Moonen D, Lee C, Lee AY, Schaffer DV, He L. CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection. Cell Reports. 27: 3780-3789.e4. PMID 31242412 DOI: 10.1016/J.Celrep.2019.05.103 |
0.37 |
|
| 2019 |
Zimmermann JA, Schaffer DV. Engineering biomaterials to control the neural differentiation of stem cells. Brain Research Bulletin. 150: 50-60. PMID 31103526 DOI: 10.1016/J.Brainresbull.2019.05.007 |
0.414 |
|
| 2019 |
Barnes C, Scheideler O, Schaffer D. Engineering the AAV capsid to evade immune responses. Current Opinion in Biotechnology. 60: 99-103. PMID 30807882 DOI: 10.1016/J.Copbio.2019.01.002 |
0.391 |
|
| 2018 |
Adil MM, Schaffer DV. Cheaper and less variable expansion. Nature Biomedical Engineering. 2: 144-145. PMID 31015716 DOI: 10.1038/S41551-018-0209-Y |
0.305 |
|
| 2018 |
Nierode GJ, Gopal S, Kwon P, Clark DS, Schaffer DV, Dordick JS. High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture. Biotechnology and Bioengineering. PMID 30229860 DOI: 10.1002/Bit.26839 |
0.372 |
|
| 2018 |
Sun S, Schaffer DV. Corrigendum to "Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits" [Curr. Opin. Neurobiol. 50 (2018) 163-170]. Current Opinion in Neurobiology. PMID 30196036 DOI: 10.1016/J.Conb.2018.08.005 |
0.306 |
|
| 2018 |
Muckom R, McFarland S, Yang C, Perea B, Gentes M, Murugappan A, Tran E, Dordick JS, Clark DS, Schaffer DV. High-Throughput Combinatorial Screening Reveals Interactions Between Signaling Molecules that Regulate Adult Neural Stem Cell Fate. Biotechnology and Bioengineering. PMID 30102775 DOI: 10.1002/Bit.26815 |
0.38 |
|
| 2018 |
Hauser M, Yan R, Li W, Repina NA, Schaffer DV, Xu K. The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage. Cell Reports. 24: 1512-1522. PMID 30089262 DOI: 10.1016/J.Celrep.2018.07.005 |
0.318 |
|
| 2018 |
Schaffer D, Shvartsman SY. Editorial overview: Tissue, cell and pathway engineering. Current Opinion in Biotechnology. 52: iv-v. PMID 30086879 DOI: 10.1016/j.copbio.2018.07.004 |
0.498 |
|
| 2018 |
Dong M, Spelke DP, Lee YK, Chung JK, Yu CH, Schaffer DV, Groves JT. Spatiomechanical Modulation of EphB4-ephrin-B2 Signaling in Neural Stem Cell Differentiation. Biophysical Journal. PMID 30075851 DOI: 10.1016/J.Bpj.2018.06.031 |
0.33 |
|
| 2018 |
Halperin SO, Tou CJ, Wong EB, Modavi C, Schaffer DV, Dueber JE. CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window. Nature. PMID 30069054 DOI: 10.1038/S41586-018-0384-8 |
0.32 |
|
| 2018 |
Mosher KI, Schaffer DV. Proliferation versus Differentiation: Redefining Retinoic Acid's Role. Stem Cell Reports. 10: 1673-1675. PMID 29874625 DOI: 10.1016/J.Stemcr.2018.05.011 |
0.374 |
|
| 2018 |
Ekerdt BL, Fuentes CM, Lei Y, Adil MM, Ramasubramanian A, Segalman RA, Schaffer DV. Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture. Advanced Healthcare Materials. e1800225. PMID 29717823 DOI: 10.1002/Adhm.201800225 |
0.388 |
|
| 2018 |
Adil MM, Gaj T, Rao AT, Kulkarni RU, Fuentes CM, Ramadoss GN, Ekman FK, Miller EW, Schaffer DV. hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports. PMID 29628395 DOI: 10.1016/J.Stemcr.2018.03.007 |
0.379 |
|
| 2018 |
Sun S, Schaffer DV. Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits. Current Opinion in Neurobiology. 50: 163-170. PMID 29614429 DOI: 10.1016/J.Conb.2017.12.011 |
0.389 |
|
| 2018 |
Adil MM, Schaffer DV. hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial. Current Protocols in Stem Cell Biology. 44: 2D.21.1-2D.21.17. PMID 29512105 DOI: 10.1002/Cpsc.47 |
0.346 |
|
| 2018 |
Day TP, Byrne LC, Flannery JG, Schaffer DV. Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. Methods in Molecular Biology (Clifton, N.J.). 1715: 239-249. PMID 29188518 DOI: 10.1007/978-1-4939-7522-8_17 |
0.6 |
|
| 2018 |
Fuentes CM, Schaffer DV. Adeno-associated virus-mediated delivery of CRISPR-Cas9 for genome editing in the central nervous system Current Opinion in Biomedical Engineering. 7: 33-41. DOI: 10.1016/J.Cobme.2018.08.003 |
0.385 |
|
| 2017 |
Kang P, Kumar S, Schaffer D. Novel biomaterials to study neural stem cell mechanobiology and improve cell-replacement therapies. Current Opinion in Biomedical Engineering. 4: 13-20. PMID 29399646 DOI: 10.1016/J.Cobme.2017.09.005 |
0.409 |
|
| 2017 |
Mukherjee A, Repina NA, Schaffer DV, Kane RS. Optogenetic tools for cell biological applications. Journal of Thoracic Disease. 9: 4867-4870. PMID 29312679 DOI: 10.21037/Jtd.2017.11.73 |
0.337 |
|
| 2017 |
Gaj T, Ojala DS, Ekman FK, Byrne LC, Limsirichai P, Schaffer DV. In vivo genome editing improves motor function and extends survival in a mouse model of ALS. Science Advances. 3: eaar3952. PMID 29279867 DOI: 10.1126/Sciadv.Aar3952 |
0.304 |
|
| 2017 |
Kang PH, Kumar S, Schaffer DV. Matrix degradation: Making way for neural stemness. Nature Materials. 16: 1174-1176. PMID 29170553 DOI: 10.1038/Nmat5043 |
0.369 |
|
| 2017 |
Epstein BE, Schaffer DV. Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing. Advances in Experimental Medicine and Biology. 1016: 29-42. PMID 29130152 DOI: 10.1007/978-3-319-63904-8_2 |
0.388 |
|
| 2017 |
Mosher KI, Schaffer DV. Influence of hippocampal niche signals on neural stem cell functions during aging. Cell and Tissue Research. PMID 29124394 DOI: 10.1007/S00441-017-2709-6 |
0.386 |
|
| 2017 |
Ojala DS, Sun S, Santiago-Ortiz JL, Shapiro MG, Romero PA, Schaffer DV. In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28988711 DOI: 10.1016/J.Ymthe.2017.09.006 |
0.479 |
|
| 2017 |
Wooley DP, Sharma P, Weinstein JR, Narayan PKL, Schaffer DV, Excoffon KJDA. A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line. Journal of Virological Methods. PMID 28918073 DOI: 10.1016/J.Jviromet.2017.09.008 |
0.358 |
|
| 2017 |
Sinn PL, Hwang BY, Li N, Ortiz JLS, Shirazi E, Parekh KR, Cooney AL, Schaffer DV, McCray PB. Novel GP64 envelope variants for improved delivery to human airway epithelial cells. Gene Therapy. PMID 28880020 DOI: 10.1038/Gt.2017.78 |
0.353 |
|
| 2017 |
Repina NA, Rosenbloom A, Mukherjee A, Schaffer DV, Kane RS. At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior. Annual Review of Chemical and Biomolecular Engineering. 8: 13-39. PMID 28592174 DOI: 10.1146/Annurev-Chembioeng-060816-101254 |
0.357 |
|
| 2017 |
Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV. Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System. Stem Cell Reports. PMID 28552605 DOI: 10.1016/J.Stemcr.2017.04.027 |
0.368 |
|
| 2017 |
Adil MM, Vazin T, Ananthanarayanan B, Rodrigues GMC, Rao AT, Kulkarni RU, Miller EW, Kumar S, Schaffer DV. Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons. Biomaterials. 136: 1-11. PMID 28505596 DOI: 10.1016/J.Biomaterials.2017.05.008 |
0.323 |
|
| 2017 |
Gaj T, Staahl BT, Rodrigues GM, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV. Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery. Nucleic Acids Research. PMID 28334779 DOI: 10.1093/Nar/Gkx154 |
0.384 |
|
| 2017 |
Adil MM, Rodrigues GM, Kulkarni RU, Rao AT, Chernavsky NE, Miller EW, Schaffer DV. Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform. Scientific Reports. 7: 40573. PMID 28091566 DOI: 10.1038/Srep40573 |
0.365 |
|
| 2017 |
Adil MM, Schaffer DV. Expansion of human pluripotent stem cells Current Opinion in Chemical Engineering. 15: 24-35. DOI: 10.1016/J.Coche.2016.11.002 |
0.388 |
|
| 2016 |
Nierode GJ, Perea BC, McFarland SK, Pascoal JF, Clark DS, Schaffer DV, Dordick JS. High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform. Stem Cell Reports. 7: 970-982. PMID 28157485 DOI: 10.1016/J.Stemcr.2016.10.001 |
0.338 |
|
| 2016 |
Gaj T, Schaffer DV. Adeno-Associated Virus-Mediated Delivery of CRISPR-Cas Systems for Genome Engineering in Mammalian Cells. Cold Spring Harbor Protocols. 2016: pdb.prot086868. PMID 27803249 DOI: 10.1101/Pdb.Prot086868 |
0.429 |
|
| 2016 |
Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, ... ... Schaffer DV, et al. A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons. Neuron. PMID 27720486 DOI: 10.1016/J.Neuron.2016.09.021 |
0.373 |
|
| 2016 |
Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, ... ... Schaffer DV, et al. CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes. Jci Insight. 1: e88728. PMID 27699238 DOI: 10.1172/Jci.Insight.88728 |
0.365 |
|
| 2016 |
Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B. Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell Reports. 17: 165-78. PMID 27681429 DOI: 10.1016/J.Celrep.2016.08.078 |
0.571 |
|
| 2016 |
Rammensee S, Kang MS, Georgiou K, Kumar S, Schaffer DV. Dynamics of Mechanosensitive Neural Stem Cell Differentiation. Stem Cells (Dayton, Ohio). PMID 27573749 DOI: 10.1002/Stem.2489 |
0.38 |
|
| 2016 |
Sun S, Schaffer DV. Viral infection: A key host receptor for AAV. Nature Microbiology. 1: 15027. PMID 27572162 DOI: 10.1038/Nmicrobiol.2015.27 |
0.351 |
|
| 2016 |
Luque T, Kang MS, Schaffer DV, Kumar S. Microelastic mapping of the rat dentate gyrus. Royal Society Open Science. 3: 150702. PMID 27152213 DOI: 10.1098/Rsos.150702 |
0.328 |
|
| 2016 |
Zheng B, von See MP, Yu E, Gunel B, Lu K, Vazin T, Schaffer DV, Goodwill PW, Conolly SM. Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo. Theranostics. 6: 291-301. PMID 26909106 DOI: 10.7150/Thno.13728 |
0.332 |
|
| 2016 |
Santiago-Ortiz JL, Schaffer DV. Adeno-associated virus (AAV) vectors in cancer gene therapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26796040 DOI: 10.1016/J.Jconrel.2016.01.001 |
0.361 |
|
| 2016 |
Chen S, Bremer AW, Scheideler OJ, Na YS, Todhunter ME, Hsiao S, Bomdica PR, Maharbiz MM, Gartner ZJ, Schaffer DV. Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities. Nature Communications. 7: 10309. PMID 26754526 DOI: 10.1038/Ncomms10309 |
0.399 |
|
| 2016 |
Byrne LC, Visel M, Dufour V, Marinho FP, Aguirre GD, Beltran WA, Flannery JG, Schaffer DV. 617. Identification of Novel AAV Capsid Variants with Enhanced Tropism for the Canine Outer Retina Following Intravitreal Delivery Molecular Therapy. 24: S244-S245. DOI: 10.1016/S1525-0016(16)33425-6 |
0.598 |
|
| 2016 |
Limsirichai P, Gaj T, Schaffer DV. 125. Purging Latent HIV Infection by CRISPR-Mediated Viral Reactivation Molecular Therapy. 24: S52. DOI: 10.1016/S1525-0016(16)32934-3 |
0.318 |
|
| 2016 |
Epstein BE, Schaffer DV. 119. Engineering a Self-Inactivating CRISPR System for AAV Vectors Molecular Therapy. 24: S50. DOI: 10.1016/S1525-0016(16)32928-8 |
0.33 |
|
| 2015 |
A Kotterman M, Schaffer DV. Engineered AAV vectors for improved central nervous system gene delivery. Neurogenesis (Austin, Tex.). 2: e1122700. PMID 27606332 DOI: 10.1080/23262133.2015.1122700 |
0.373 |
|
| 2015 |
Kotterman MA, Chalberg TW, Schaffer DV. Viral Vectors for Gene Therapy: Translational and Clinical Outlook. Annual Review of Biomedical Engineering. 17: 63-89. PMID 26643018 DOI: 10.1146/Annurev-Bioeng-071813-104938 |
0.398 |
|
| 2015 |
Limsirichai P, Gaj T, Schaffer DV. CRISPR-mediated activation of latent HIV-1 expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26607397 DOI: 10.1038/Mt.2015.213 |
0.332 |
|
| 2015 |
Gaj T, Epstein BE, Schaffer DV. Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26373345 DOI: 10.1038/Mt.2015.151 |
0.389 |
|
| 2015 |
Zheng B, Vazin T, Goodwill PW, Conway A, Verma A, Ulku Saritas E, Schaffer D, Conolly SM. Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast. Scientific Reports. 5: 14055. PMID 26358296 DOI: 10.1038/Srep14055 |
0.592 |
|
| 2015 |
Santiago-Ortiz J, Ojala DS, Westesson O, Weinstein JR, Wong SY, Steinsapir A, Kumar S, Holmes I, Schaffer DV. AAV ancestral reconstruction library enables selection of broadly infectious viral variants. Gene Therapy. PMID 26186661 DOI: 10.1038/Gt.2015.74 |
0.416 |
|
| 2015 |
Han BW, Layman H, Rode NA, Conway A, Schaffer DV, Boudreau NJ, Jackson WM, Healy KE. Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing. Tissue Engineering. Part A. 21: 2366-78. PMID 26154888 DOI: 10.1089/Ten.Tea.2014.0281 |
0.615 |
|
| 2015 |
Kotterman MA, Vazin T, Schaffer DV. Enhanced selective gene delivery to neural stem cells in vivo by an adeno-associated viral variant. Development (Cambridge, England). 142: 1885-92. PMID 25968319 DOI: 10.1242/Dev.115253 |
0.495 |
|
| 2015 |
Dey SS, Foley JE, Limsirichai P, Schaffer DV, Arkin AP. Orthogonal control of expression mean and variance by epigenetic features at different genomic loci. Molecular Systems Biology. 11: 806. PMID 25943345 DOI: 10.15252/Msb.20145704 |
0.712 |
|
| 2015 |
Bugaj LJ, Spelke DP, Mesuda CK, Varedi M, Kane RS, Schaffer DV. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nature Communications. 6: 6898. PMID 25902152 DOI: 10.1038/Ncomms7898 |
0.324 |
|
| 2015 |
Jha AK, Tharp KM, Ye J, Santiago-Ortiz JL, Jackson WM, Stahl A, Schaffer DV, Yeghiazarians Y, Healy KE. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials. 47: 1-12. PMID 25682155 DOI: 10.1016/J.Biomaterials.2014.12.043 |
0.333 |
|
| 2015 |
Fritz AL, Adil MM, Mao SR, Schaffer DV. cAMP and EPAC Signaling Functionally Replace OCT4 During Induced Pluripotent Stem Cell Reprogramming. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 952-63. PMID 25666918 DOI: 10.1038/Mt.2015.28 |
0.393 |
|
| 2015 |
Yousef H, Morgenthaler A, Schlesinger C, Bugaj L, Conboy IM, Schaffer DV. Age-Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis. Stem Cells (Dayton, Ohio). 33: 1577-88. PMID 25538007 DOI: 10.1002/Stem.1943 |
0.368 |
|
| 2015 |
Kotterman MA, Yin L, Strazzeri JM, Flannery JG, Merigan WH, Schaffer DV. Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates. Gene Therapy. 22: 116-26. PMID 25503696 DOI: 10.1038/Gt.2014.115 |
0.588 |
|
| 2015 |
Byrne LC, Lin YJ, Lee T, Schaffer DV, Flannery JG. The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 290-6. PMID 25224467 DOI: 10.1038/Mt.2014.181 |
0.593 |
|
| 2015 |
Fritz AL, Mao SR, West MG, Schaffer DV. A medium-throughput analysis of signaling pathways involved in early stages of stem cell reprogramming. Biotechnology and Bioengineering. 112: 209-19. PMID 25065366 DOI: 10.1002/Bit.25336 |
0.404 |
|
| 2015 |
Ojala DS, Amara DP, Schaffer DV. Adeno-associated virus vectors and neurological gene therapy. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 21: 84-98. PMID 24557878 DOI: 10.1177/1073858414521870 |
0.401 |
|
| 2015 |
Kotterman MA, Hwang B, Schaffer DV. 261. Directed Evolution of an Antibody-Evading Cardiac Tropic AAV Vector Molecular Therapy. 23: S104. DOI: 10.1016/S1525-0016(16)33870-9 |
0.367 |
|
| 2015 |
Ojala DS, Santiago-Ortiz J, Westesson O, Weinstein JR, Wong SY, Steinsapir A, Kumar S, Holmes I, Schaffer D. 260. AAV Ancestral Reconstruction Library Enables Selection of Broadly Infectious Viral Variants Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)33869-2 |
0.388 |
|
| 2014 |
Schaffer DV. AAV shuffles to the liver: commentary on Lisowski et al. Molecular Therapy. Methods & Clinical Development. 1: 14006. PMID 26015952 DOI: 10.1038/Mtm.2014.6 |
0.434 |
|
| 2014 |
Lei Y, Jeong D, Xiao J, Schaffer DV. Developing Defined and Scalable 3D Culture Systems for Culturing Human Pluripotent Stem Cells at High Densities. Cellular and Molecular Bioengineering. 7: 172-183. PMID 25419247 DOI: 10.1007/S12195-014-0333-Z |
0.375 |
|
| 2014 |
Hughes AJ, Spelke DP, Xu Z, Kang CC, Schaffer DV, Herr AE. Single-cell western blotting. Nature Methods. 11: 749-55. PMID 24880876 DOI: 10.1038/Nmeth.2992 |
0.376 |
|
| 2014 |
Kotterman MA, Schaffer DV. Engineering adeno-associated viruses for clinical gene therapy. Nature Reviews. Genetics. 15: 445-51. PMID 24840552 DOI: 10.1038/Nrg3742 |
0.39 |
|
| 2014 |
Yin L, Masella B, Dalkara D, Zhang J, Flannery JG, Schaffer DV, Williams DR, Merigan WH. Imaging light responses of foveal ganglion cells in the living macaque eye. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6596-605. PMID 24806684 DOI: 10.1523/Jneurosci.4438-13.2014 |
0.696 |
|
| 2014 |
Byrne LC, Oztürk BE, Lee T, Fortuny C, Visel M, Dalkara D, Schaffer DV, Flannery JG. Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. Gene Therapy. 21: 585-92. PMID 24694538 DOI: 10.1038/Gt.2014.31 |
0.757 |
|
| 2014 |
Cao J, Arha M, Sudrik C, Schaffer DV, Kane RS. Bidirectional regulation of mRNA translation in mammalian cells by using PUF domains. Angewandte Chemie (International Ed. in English). 53: 4900-4. PMID 24677733 DOI: 10.1002/Anie.201402095 |
0.301 |
|
| 2014 |
Day TP, Byrne LC, Schaffer DV, Flannery JG. Advances in AAV vector development for gene therapy in the retina. Advances in Experimental Medicine and Biology. 801: 687-93. PMID 24664759 DOI: 10.1007/978-1-4614-3209-8_86 |
0.63 |
|
| 2014 |
Bartel MA, Schaffer DV. Enhanced gene targeting of adult and pluripotent stem cells using evolved adeno-associated virus. Methods in Molecular Biology (Clifton, N.J.). 1114: 169-79. PMID 24557903 DOI: 10.1007/978-1-62703-761-7_11 |
0.476 |
|
| 2014 |
Conway A, Schaffer DV. Biomaterial microenvironments to support the generation of new neurons in the adult brain. Stem Cells (Dayton, Ohio). 32: 1220-9. PMID 24449485 DOI: 10.1002/Stem.1650 |
0.644 |
|
| 2014 |
Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM. A global assessment of stem cell engineering. Tissue Engineering. Part A. 20: 2575-89. PMID 24428577 DOI: 10.1089/Ten.Tea.2013.0468 |
0.679 |
|
| 2014 |
Vacca O, Darche M, Schaffer DV, Flannery JG, Sahel JA, Rendon A, Dalkara D. AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers. Glia. 62: 468-76. PMID 24382652 DOI: 10.1002/Glia.22617 |
0.737 |
|
| 2014 |
Vazin T, Ashton RS, Conway A, Rode NA, Lee SM, Bravo V, Healy KE, Kane RS, Schaffer DV. The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons. Biomaterials. 35: 941-8. PMID 24172856 DOI: 10.1016/J.Biomaterials.2013.10.025 |
0.643 |
|
| 2014 |
Vazin T, Ball KA, Lu H, Park H, Ataeijannati Y, Head-Gordon T, Poo MM, Schaffer DV. Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease. Neurobiology of Disease. 62: 62-72. PMID 24055772 DOI: 10.1016/J.Nbd.2013.09.005 |
0.327 |
|
| 2014 |
Conway A, Spelke DP, Schaffer DV. Conjugation of proteins to polymer chains to create multivalent molecules. Methods in Molecular Biology (Clifton, N.J.). 1202: 95-102. PMID 24014311 DOI: 10.1007/7651_2013_32 |
0.634 |
|
| 2014 |
Vazin T, Ball KA, Lu H, Park H, Ataeijannati Y, Head-Gordon T, Poo Mm, Schaffer DV. Corrigendum to "Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: A model system to study neurotoxicity in Alzheimer's disease" [Neurobiol. Dis. 62 (2014) 62-72] Neurobiology of Disease. 65: 1. DOI: 10.1016/J.Nbd.2013.12.012 |
0.34 |
|
| 2014 |
Dong M, Spelke D, Lord SJ, Schaffer DV, Groves JT. Exploring the Spatio-Mechanosensitivity of Eph Receptor in Stem Cells Biophysical Journal. 106: 519a. DOI: 10.1016/J.Bpj.2013.11.2900 |
0.374 |
|
| 2013 |
Ekerdt BL, Segalman RA, Schaffer DV. Spatial organization of cell-adhesive ligands for advanced cell culture. Biotechnology Journal. 8: 1411-23. PMID 24318636 DOI: 10.1002/Biot.201300302 |
0.346 |
|
| 2013 |
Lei Y, Schaffer DV. A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 110: E5039-48. PMID 24248365 DOI: 10.1073/Pnas.1309408110 |
0.386 |
|
| 2013 |
Conway A, Vazin T, Spelke DP, Rode NA, Healy KE, Kane RS, Schaffer DV. Multivalent ligands control stem cell behaviour in vitro and in vivo. Nature Nanotechnology. 8: 831-8. PMID 24141540 DOI: 10.1038/Nnano.2013.205 |
0.654 |
|
| 2013 |
Downing TL, Soto J, Morez C, Houssin T, Fritz A, Yuan F, Chu J, Patel S, Schaffer DV, Li S. Biophysical regulation of epigenetic state and cell reprogramming. Nature Materials. 12: 1154-62. PMID 24141451 DOI: 10.1038/Nmat3777 |
0.368 |
|
| 2013 |
Byrne LC, Khalid F, Lee T, Zin EA, Greenberg KP, Visel M, Schaffer DV, Flannery JG. AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina. Plos One. 8: e76075. PMID 24086689 DOI: 10.1371/Journal.Pone.0076075 |
0.599 |
|
| 2013 |
Miller-Jensen K, Skupsky R, Shah PS, Arkin AP, Schaffer DV. Genetic selection for context-dependent stochastic phenotypes: Sp1 and TATA mutations increase phenotypic noise in HIV-1 gene expression. Plos Computational Biology. 9: e1003135. PMID 23874178 DOI: 10.1371/Journal.Pcbi.1003135 |
0.676 |
|
| 2013 |
Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Science Translational Medicine. 5: 189ra76. PMID 23761039 DOI: 10.1126/Scitranslmed.3005708 |
0.747 |
|
| 2013 |
Keung AJ, Dong M, Schaffer DV, Kumar S. Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive. Scientific Reports. 3: 1817. PMID 23660869 DOI: 10.1038/Srep01817 |
0.688 |
|
| 2013 |
Bugaj LJ, Choksi AT, Mesuda CK, Kane RS, Schaffer DV. Optogenetic protein clustering and signaling activation in mammalian cells. Nature Methods. 10: 249-52. PMID 23377377 DOI: 10.1038/Nmeth.2360 |
0.303 |
|
| 2013 |
Hwang BY, Schaffer DV. Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors. Gene Therapy. 20: 807-15. PMID 23364315 DOI: 10.1038/Gt.2013.1 |
0.303 |
|
| 2013 |
Pernet V, Joly S, Dalkara D, Jordi N, Schwarz O, Christ F, Schaffer DV, Flannery JG, Schwab ME. Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve. Neurobiology of Disease. 51: 202-13. PMID 23194670 DOI: 10.1016/J.Nbd.2012.11.011 |
0.677 |
|
| 2013 |
Yin L, Masella BD, Geng Y, Dalkara D, Osakada F, Sharma R, Zhang J, Cetin AH, Callaway EM, Flannery JG, Schaffer DV, Williams DR, Merigan WH. Optical recording of the light response of ganglion cells in the living eye Optics Infobase Conference Papers. DOI: 10.1364/Fio.2013.Ftu4I.3 |
0.686 |
|
| 2013 |
Hogle LF, Palecek SP, Schaffer D, Zandstra PW. Characterizing international stem cell research niches Regenerative Medicine Ethics: Governing Research and Knowledge Practices. 29-65. DOI: 10.1007/978-1-4614-9062-3_2 |
0.666 |
|
| 2013 |
Kotterman MA, Asuri P, Jang JH, Vazin T, Schaffer DV. Directed evolution of adeno-associated virus for enhanced gene delivery to pluripotent and adult neural stem cells Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 324. |
0.343 |
|
| 2013 |
Kotterman MA, Hwang BY, Stone D, Koerber JT, Couto L, Mingozzi F, High K, Schaffer DV. Directed evolution of adeno-associated virus for enhanced evasion of human neutralizing antibodies Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 413-414. |
0.623 |
|
| 2012 |
Shah PS, Schaffer DV. Response to "HIV Escape From RNAi Antivirals: Yet Another Houdini Action?" Molecular Therapy. Nucleic Acids. 1: e28. PMID 28187853 DOI: 10.1038/mtna.2012.23 |
0.457 |
|
| 2012 |
Shah PS, Schaffer DV. Response to "HIV Escape From RNAi Antivirals: Yet Another Houdini Action?". Molecular Therapy. Nucleic Acids. 1: e28. PMID 23344080 DOI: 10.1038/Mtna.2012.23 |
0.535 |
|
| 2012 |
Conway A, Schaffer DV. Biophysical regulation of stem cell behavior within the niche. Stem Cell Research & Therapy. 3: 50. PMID 23241436 DOI: 10.1186/Scrt141 |
0.653 |
|
| 2012 |
Ashton RS, Conway A, Pangarkar C, Bergen J, Lim KI, Shah P, Bissell M, Schaffer DV. Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling. Nature Neuroscience. 15: 1399-406. PMID 22983209 DOI: 10.1038/Nn.3212 |
0.715 |
|
| 2012 |
Keung AJ, Asuri P, Kumar S, Schaffer DV. Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1049-58. PMID 22854634 DOI: 10.1039/C2Ib20083J |
0.726 |
|
| 2012 |
Miller-Jensen K, Dey SS, Pham N, Foley JE, Arkin AP, Schaffer DV. Chromatin accessibility at the HIV LTR promoter sets a threshold for NF-κB mediated viral gene expression. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 661-71. PMID 22555315 DOI: 10.1039/C2Ib20009K |
0.736 |
|
| 2012 |
Bartel MA, Weinstein JR, Schaffer DV. Directed evolution of novel adeno-associated viruses for therapeutic gene delivery. Gene Therapy. 19: 694-700. PMID 22402323 DOI: 10.1038/Gt.2012.20 |
0.437 |
|
| 2012 |
Jgamadze D, Bergen J, Stone D, Jang JH, Schaffer DV, Isacoff EY, Pautot S. Colloids as mobile substrates for the implantation and integration of differentiated neurons into the mammalian brain. Plos One. 7: e30293. PMID 22295079 DOI: 10.1371/Journal.Pone.0030293 |
0.327 |
|
| 2012 |
Shah PS, Pham NP, Schaffer DV. HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 840-8. PMID 22294151 DOI: 10.1038/Mt.2012.3 |
0.561 |
|
| 2012 |
Asokan A, Schaffer DV, Samulski RJ. The AAV vector toolkit: poised at the clinical crossroads. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 699-708. PMID 22273577 DOI: 10.1038/Mt.2011.287 |
0.367 |
|
| 2012 |
Dey SS, Xue Y, Joachimiak MP, Friedland GD, Burnett JC, Zhou Q, Arkin AP, Schaffer DV. Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression. The Journal of Biological Chemistry. 287: 7945-55. PMID 22253435 DOI: 10.1074/Jbc.M111.302653 |
0.725 |
|
| 2012 |
Pernet V, Joly S, Dalkara D, Schwarz O, Christ F, Schaffer D, Flannery JG, Schwab ME. Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina. Cell Death and Differentiation. 19: 1096-108. PMID 22193546 DOI: 10.1038/Cdd.2011.191 |
0.71 |
|
| 2012 |
An HJ, Gip P, Kim J, Wu S, Park KW, McVaugh CT, Schaffer DV, Bertozzi CR, Lebrilla CB. Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. Molecular & Cellular Proteomics : McP. 11: M111.010660. PMID 22147732 DOI: 10.1074/Mcp.M111.010660 |
0.796 |
|
| 2012 |
Asuri P, Bartel MA, Vazin T, Jang JH, Wong TB, Schaffer DV. Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 329-38. PMID 22108859 DOI: 10.1038/Mt.2011.255 |
0.468 |
|
| 2012 |
Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG. Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9. Gene Therapy. 19: 176-81. PMID 22011645 DOI: 10.1038/Gt.2011.163 |
0.739 |
|
| 2012 |
Yin L, Masella B, Dalkara D, Flannery JG, Schaffer DV, Williams DR, Merigan WH. In vivo imaging of ganglion cell physiology in macaque fovea using a calcium indicator Journal of Vision. 12: 55-55. DOI: 10.1167/12.14.55 |
0.69 |
|
| 2012 |
Lord SJ, Greene AC, Lee IJ, Spelke D, Schaffer DV, Groves JT. Spatial Organization of EphA2 and its Effects on Internalization and Signaling in Living Cells Biophysical Journal. 102: 667a. DOI: 10.1016/J.Bpj.2011.11.3633 |
0.315 |
|
| 2011 |
Ashton RS, Keung AJ, Peltier J, Schaffer DV. Progress and prospects for stem cell engineering. Annual Review of Chemical and Biomolecular Engineering. 2: 479-502. PMID 22432628 DOI: 10.1146/Annurev-Chembioeng-061010-114105 |
0.809 |
|
| 2011 |
Bartel M, Schaffer D, Büning H. Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity. Frontiers in Microbiology. 2: 204. PMID 22065962 DOI: 10.3389/Fmicb.2011.00204 |
0.34 |
|
| 2011 |
Keung AJ, de Juan-Pardo EM, Schaffer DV, Kumar S. Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells. Stem Cells (Dayton, Ohio). 29: 1886-97. PMID 21956892 DOI: 10.1002/Stem.746 |
0.724 |
|
| 2011 |
Shah PS, Schaffer DV. Antiviral RNAi: translating science towards therapeutic success. Pharmaceutical Research. 28: 2966-82. PMID 21826573 DOI: 10.1007/S11095-011-0549-8 |
0.557 |
|
| 2011 |
Hester ME, Murtha MJ, Song S, Rao M, Miranda CJ, Meyer K, Tian J, Boulting G, Schaffer DV, Zhu MX, Pfaff SL, Gage FH, Kaspar BK. Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1905-12. PMID 21772256 DOI: 10.1038/Mt.2011.135 |
0.775 |
|
| 2011 |
Miller-Jensen K, Dey SS, Schaffer DV, Arkin AP. Varying virulence: epigenetic control of expression noise and disease processes. Trends in Biotechnology. 29: 517-25. PMID 21700350 DOI: 10.1016/J.Tibtech.2011.05.004 |
0.659 |
|
| 2011 |
Dickey DD, Excoffon KJ, Koerber JT, Bergen J, Steines B, Klesney-Tait J, Schaffer DV, Zabner J. Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus. Journal of Virology. 85: 9023-30. PMID 21697483 DOI: 10.1128/Jvi.05154-11 |
0.65 |
|
| 2011 |
Jang JH, Schaffer DV, Shea LD. Engineering biomaterial systems to enhance viral vector gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1407-15. PMID 21629221 DOI: 10.1038/Mt.2011.111 |
0.423 |
|
| 2011 |
Dalkara D, Kolstad KD, Guerin KI, Hoffmann NV, Visel M, Klimczak RR, Schaffer DV, Flannery JG. AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1602-8. PMID 21522134 DOI: 10.1038/Mt.2011.62 |
0.738 |
|
| 2011 |
Arkin AP, Schaffer DV. Network news: innovations in 21st century systems biology. Cell. 144: 844-9. PMID 21414475 DOI: 10.1016/J.Cell.2011.03.008 |
0.469 |
|
| 2011 |
Yin L, Greenberg K, Hunter JJ, Dalkara D, Kolstad KD, Masella BD, Wolfe R, Visel M, Stone D, Libby RT, Diloreto D, Schaffer D, Flannery J, Williams DR, Merigan WH. Intravitreal injection of AAV2 transduces macaque inner retina. Investigative Ophthalmology & Visual Science. 52: 2775-83. PMID 21310920 DOI: 10.1167/Iovs.10-6250 |
0.703 |
|
| 2011 |
Jang JH, Koerber JT, Kim JS, Asuri P, Vazin T, Bartel M, Keung A, Kwon I, Park KI, Schaffer DV. An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 667-75. PMID 21224831 DOI: 10.1038/Mt.2010.287 |
0.832 |
|
| 2011 |
Dickinson BC, Peltier J, Stone D, Schaffer DV, Chang CJ. Nox2 redox signaling maintains essential cell populations in the brain. Nature Chemical Biology. 7: 106-12. PMID 21186346 DOI: 10.1038/Nchembio.497 |
0.747 |
|
| 2011 |
Little LE, Dane KY, Daugherty PS, Healy KE, Schaffer DV. Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell culture. Biomaterials. 32: 1484-94. PMID 21129772 DOI: 10.1016/J.Biomaterials.2010.10.032 |
0.696 |
|
| 2011 |
Peltier J, Conway A, Keung AJ, Schaffer DV. Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation. Stem Cells and Development. 20: 1153-61. PMID 21028992 DOI: 10.1089/Scd.2010.0130 |
0.798 |
|
| 2011 |
Chen S, Patel N, Schaffer D, Maharbiz MM. Trap and corral: A two-step approach for constructing and constraining dynamic cell contact events in differentiating progenitor cell populations Journal of Micromechanics and Microengineering. 21. DOI: 10.1088/0960-1317/21/5/054027 |
0.373 |
|
| 2011 |
Keung AJ, Kumar S, Schaffer DV. ChemInform Abstract: Microenvironmental Regulation of Stem Cells by Biophysical and Material Cues Cheminform. 42: no-no. DOI: 10.1002/chin.201127263 |
0.665 |
|
| 2010 |
Saha K, Kim J, Irwin E, Yoon J, Momin F, Trujillo V, Schaffer DV, Healy KE, Hayward RC. Surface creasing instability of soft polyacrylamide cell culture substrates. Biophysical Journal. 99: L94-6. PMID 21156124 DOI: 10.1016/J.Bpj.2010.09.045 |
0.579 |
|
| 2010 |
Willerth SM, Pedro HA, Pachter L, Humeau LM, Arkin AP, Schaffer DV. Development of a low bias method for characterizing viral populations using next generation sequencing technology. Plos One. 5: e13564. PMID 21042592 DOI: 10.1371/Journal.Pone.0013564 |
0.493 |
|
| 2010 |
Skupsky R, Burnett JC, Foley JE, Schaffer DV, Arkin AP. HIV promoter integration site primarily modulates transcriptional burst size rather than frequency. Plos Computational Biology. 6. PMID 20941390 DOI: 10.1371/Journal.Pcbi.1000952 |
0.731 |
|
| 2010 |
Keung AJ, Healy KE, Kumar S, Schaffer DV. Biophysics and dynamics of natural and engineered stem cell microenvironments. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2: 49-64. PMID 20836010 DOI: 10.1002/Wsbm.46 |
0.719 |
|
| 2010 |
Ananthanarayanan B, Little L, Schaffer DV, Healy KE, Tirrell M. Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides. Biomaterials. 31: 8706-15. PMID 20728935 DOI: 10.1016/J.Biomaterials.2010.07.104 |
0.674 |
|
| 2010 |
Aviran S, Shah PS, Schaffer DV, Arkin AP. Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles. Plos Computational Biology. 6. PMID 20711350 DOI: 10.1371/Journal.Pcbi.1000883 |
0.691 |
|
| 2010 |
Lim KI, Klimczak R, Yu JH, Schaffer DV. Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties. Proceedings of the National Academy of Sciences of the United States of America. 107: 12475-80. PMID 20616052 DOI: 10.1073/Pnas.1001402107 |
0.544 |
|
| 2010 |
Keung AJ, Kumar S, Schaffer DV. Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues. Annual Review of Cell and Developmental Biology. 26: 533-56. PMID 20590452 DOI: 10.1146/Annurev-Cellbio-100109-104042 |
0.725 |
|
| 2010 |
Shah PS, Schaffer DV. Gene therapy takes a cue from HAART: combinatorial antiviral therapeutics reach the clinic. Science Translational Medicine. 2: 36ps30. PMID 20555021 DOI: 10.1126/Scitranslmed.3001298 |
0.583 |
|
| 2010 |
Jang JH, Koerber JT, Gujraty K, Bethi SR, Kane RS, Schaffer DV. Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery. Gene Therapy. 17: 1384-9. PMID 20508598 DOI: 10.1038/Gt.2010.81 |
0.706 |
|
| 2010 |
Peltier J, Schaffer DV. Viral packaging and transduction of adult hippocampal neural progenitors. Methods in Molecular Biology (Clifton, N.J.). 621: 103-16. PMID 20405362 DOI: 10.1007/978-1-60761-063-2_7 |
0.786 |
|
| 2010 |
Robertson MJ, Peltier J, Schaffer DV. In vivo analysis of engrafted adult hippocampal neural progenitors. Methods in Molecular Biology (Clifton, N.J.). 621: 89-102. PMID 20405361 DOI: 10.1007/978-1-60761-063-2_6 |
0.807 |
|
| 2010 |
Peltier J, Agrawal S, Robertson MJ, Schaffer DV. In vitro culture and analysis of adult hippocampal neural progenitors. Methods in Molecular Biology (Clifton, N.J.). 621: 65-87. PMID 20405360 DOI: 10.1007/978-1-60761-063-2_5 |
0.79 |
|
| 2010 |
Peltier J, Ormerod BK, Schaffer DV. Isolation of adult hippocampal neural progenitors. Methods in Molecular Biology (Clifton, N.J.). 621: 57-63. PMID 20405359 DOI: 10.1007/978-1-60761-063-2_4 |
0.752 |
|
| 2010 |
Burnett JC, Lim KI, Calafi A, Rossi JJ, Schaffer DV, Arkin AP. Combinatorial latency reactivation for HIV-1 subtypes and variants. Journal of Virology. 84: 5958-74. PMID 20357084 DOI: 10.1128/Jvi.00161-10 |
0.686 |
|
| 2010 |
Kurpinski K, Lam H, Chu J, Wang A, Kim A, Tsay E, Agrawal S, Schaffer DV, Li S. Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells. Stem Cells (Dayton, Ohio). 28: 734-42. PMID 20146266 DOI: 10.1002/Stem.319 |
0.56 |
|
| 2010 |
Vazin T, Schaffer DV. Engineering strategies to emulate the stem cell niche. Trends in Biotechnology. 28: 117-24. PMID 20042248 DOI: 10.1016/J.Tibtech.2009.11.008 |
0.405 |
|
| 2010 |
Kolstad KD, Dalkara D, Guerin K, Visel M, Hoffmann N, Schaffer DV, Flannery JG. Changes in adeno-associated virus-mediated gene delivery in retinal degeneration. Human Gene Therapy. 21: 571-8. PMID 20021232 DOI: 10.1089/Hum.2009.194 |
0.738 |
|
| 2010 |
Peltier J, Schaffer DV. Systems biology approaches to understanding stem cell fate choice. Iet Systems Biology. 4: 1-11. PMID 20001088 DOI: 10.1049/Iet-Syb.2009.0011 |
0.785 |
|
| 2010 |
Meng Y, Eshghi S, Li YJ, Schmidt R, Schaffer DV, Healy KE. Characterization of integrin engagement during defined human embryonic stem cell culture. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1056-65. PMID 19933311 DOI: 10.1096/Fj.08-126821 |
0.362 |
|
| 2010 |
Keung AJ, de Juan-Pardo EM, Schaffer DV, Kumar S. Mechanotransductive Engineering of Neural Stem Cell Behavior Biophysical Journal. 98: 404a-405a. DOI: 10.1016/J.Bpj.2009.12.2181 |
0.713 |
|
| 2009 |
Klimczak RR, Koerber JT, Dalkara D, Flannery JG, Schaffer DV. A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells. Plos One. 4: e7467. PMID 19826483 DOI: 10.1371/Journal.Pone.0007467 |
0.819 |
|
| 2009 |
Carlson ME, Conboy MJ, Hsu M, Barchas L, Jeong J, Agrawal A, Mikels AJ, Agrawal S, Schaffer DV, Conboy IM. Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell. 8: 676-89. PMID 19732043 DOI: 10.1111/J.1474-9726.2009.00517.X |
0.486 |
|
| 2009 |
Dalkara D, Kolstad KD, Caporale N, Visel M, Klimczak RR, Schaffer DV, Flannery JG. Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2096-102. PMID 19672248 DOI: 10.1038/Mt.2009.181 |
0.73 |
|
| 2009 |
Koerber JT, Klimczak R, Jang JH, Dalkara D, Flannery JG, Schaffer DV. Molecular evolution of adeno-associated virus for enhanced glial gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2088-95. PMID 19672246 DOI: 10.1038/Mt.2009.184 |
0.824 |
|
| 2009 |
Banerjee A, Arha M, Choudhary S, Ashton RS, Bhatia SR, Schaffer DV, Kane RS. The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells. Biomaterials. 30: 4695-9. PMID 19539367 DOI: 10.1016/J.Biomaterials.2009.05.050 |
0.387 |
|
| 2009 |
Agrawal S, Archer C, Schaffer DV. Computational models of the Notch network elucidate mechanisms of context-dependent signaling. Plos Computational Biology. 5: e1000390. PMID 19468305 DOI: 10.1371/Journal.Pcbi.1000390 |
0.554 |
|
| 2009 |
Excoffon KJ, Koerber JT, Dickey DD, Murtha M, Keshavjee S, Kaspar BK, Zabner J, Schaffer DV. Directed evolution of adeno-associated virus to an infectious respiratory virus. Proceedings of the National Academy of Sciences of the United States of America. 106: 3865-70. PMID 19237554 DOI: 10.1073/Pnas.0813365106 |
0.799 |
|
| 2009 |
Burnett JC, Miller-Jensen K, Shah PS, Arkin AP, Schaffer DV. Control of stochastic gene expression by host factors at the HIV promoter. Plos Pathogens. 5: e1000260. PMID 19132086 DOI: 10.1371/Journal.Ppat.1000260 |
0.735 |
|
| 2008 |
Eshghi S, Schaffer DV. Engineering microenvironments to control stem cell fate and function Stembook. PMID 20614608 DOI: 10.3824/Stembook.1.5.1 |
0.417 |
|
| 2008 |
Leonard JN, Shah PS, Burnett JC, Schaffer DV. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host & Microbe. 4: 484-94. PMID 18996348 DOI: 10.1016/J.Chom.2008.09.008 |
0.736 |
|
| 2008 |
Koerber JT, Jang JH, Schaffer DV. DNA shuffling of adeno-associated virus yields functionally diverse viral progeny. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1703-9. PMID 18728640 DOI: 10.1038/Mt.2008.167 |
0.726 |
|
| 2008 |
Saha K, Keung AJ, Irwin EF, Li Y, Little L, Schaffer DV, Healy KE. Substrate modulus directs neural stem cell behavior. Biophysical Journal. 95: 4426-38. PMID 18658232 DOI: 10.1529/Biophysj.108.132217 |
0.804 |
|
| 2008 |
Schaffer DV, Koerber JT, Lim KI. Molecular engineering of viral gene delivery vehicles. Annual Review of Biomedical Engineering. 10: 169-94. PMID 18647114 DOI: 10.1146/Annurev.Bioeng.10.061807.160514 |
0.714 |
|
| 2008 |
Little L, Healy KE, Schaffer D. Engineering biomaterials for synthetic neural stem cell microenvironments. Chemical Reviews. 108: 1787-96. PMID 18476674 DOI: 10.1021/Cr078228T |
0.717 |
|
| 2008 |
Koerber JT, Schaffer DV. Transposon-based mutagenesis generates diverse adeno-associated viral libraries with novel gene delivery properties. Methods in Molecular Biology (Clifton, N.J.). 434: 161-70. PMID 18470644 DOI: 10.1007/978-1-60327-248-3_10 |
0.715 |
|
| 2008 |
Wall ST, Saha K, Ashton RS, Kam KR, Schaffer DV, Healy KE. Multivalency of Sonic hedgehog conjugated to linear polymer chains modulates protein potency. Bioconjugate Chemistry. 19: 806-12. PMID 18380472 DOI: 10.1021/Bc700265K |
0.551 |
|
| 2008 |
Lim KI, Schaffer DV. Library selection approaches to engineering enhanced retroviral and lentiviral vectors. Combinatorial Chemistry & High Throughput Screening. 11: 111-7. PMID 18336204 DOI: 10.2174/138620708783744444 |
0.418 |
|
| 2008 |
Ricci C, Pastukh V, Leonard J, Turrens J, Wilson G, Schaffer D, Schaffer SW. Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis. American Journal of Physiology. Cell Physiology. 294: C413-22. PMID 18077603 DOI: 10.1152/Ajpcell.00362.2007 |
0.538 |
|
| 2008 |
Robertson MJ, Gip P, Schaffer DV. Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons. Frontiers in Bioscience : a Journal and Virtual Library. 13: 21-50. PMID 17981526 DOI: 10.2741/2558 |
0.816 |
|
| 2008 |
Kwon I, Schaffer DV. Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transfer. Pharmaceutical Research. 25: 489-99. PMID 17763830 DOI: 10.1007/S11095-007-9431-0 |
0.445 |
|
| 2008 |
Miller-Jensen K, Lauffenburger DA, Schaffer DV. Systems biology approaches to studying intracellular signaling interactions between virus and host Aiche Annual Meeting, Conference Proceedings. |
0.395 |
|
| 2008 |
Koerber JT, Excoffon K, Kaspar B, Zabner J, Schaffer DV. Engineering of a novel AAV vector in a human airway model system for cystic fibrosis gene therapy Aiche Annual Meeting, Conference Proceedings. |
0.741 |
|
| 2008 |
Kwon I, Koerber JT, Schaffer DV. Directed evolution of AAV to target tissue-specific vascular endothelium Aiche Annual Meeting, Conference Proceedings. |
0.599 |
|
| 2008 |
Koerber JT, Schaffer DV. A rapid, general platform to identify structure/function relationships of a viral protein Aiche Annual Meeting, Conference Proceedings. |
0.618 |
|
| 2007 |
Schaffer D. Exploring and Engineering Stem Cells and their Niches. Current Opinion in Chemical Biology. 11: 355-356. PMID 18670582 DOI: 10.1016/J.Cbpa.2007.07.001 |
0.384 |
|
| 2007 |
Ashton RS, Banerjee A, Punyani S, Schaffer DV, Kane RS. Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Biomaterials. 28: 5518-25. PMID 17881048 DOI: 10.1016/J.Biomaterials.2007.08.038 |
0.34 |
|
| 2007 |
Ashton RS, Peltier J, Fasano CA, O'Neill A, Leonard J, Temple S, Schaffer DV, Kane RS. High-throughput screening of gene function in stem cells using clonal microarrays. Stem Cells (Dayton, Ohio). 25: 2928-35. PMID 17673524 DOI: 10.1634/Stemcells.2007-0468 |
0.809 |
|
| 2007 |
Saha K, Pollock JF, Schaffer DV, Healy KE. Designing synthetic materials to control stem cell phenotype. Current Opinion in Chemical Biology. 11: 381-7. PMID 17669680 DOI: 10.1016/J.Cbpa.2007.05.030 |
0.589 |
|
| 2007 |
Peltier J, O'Neill A, Schaffer DV. PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Developmental Neurobiology. 67: 1348-61. PMID 17638387 DOI: 10.1002/Dneu.20506 |
0.793 |
|
| 2007 |
Jang JH, Lim KI, Schaffer DV. Library selection and directed evolution approaches to engineering targeted viral vectors. Biotechnology and Bioengineering. 98: 515-24. PMID 17614321 DOI: 10.1002/Bit.21541 |
0.418 |
|
| 2007 |
Ho JE, Chung EH, Wall S, Schaffer DV, Healy KE. Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived mesenchymal stem cells. Journal of Biomedical Materials Research. Part A. 83: 1200-8. PMID 17600327 DOI: 10.1002/Jbm.A.31355 |
0.324 |
|
| 2007 |
Koerber JT, Jang JH, Yu JH, Kane RS, Schaffer DV. Engineering adeno-associated virus for one-step purification via immobilized metal affinity chromatography. Human Gene Therapy. 18: 367-78. PMID 17437357 DOI: 10.1089/Hum.2006.139 |
0.766 |
|
| 2007 |
Greenberg KP, Geller SF, Schaffer DV, Flannery JG. Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors. Investigative Ophthalmology & Visual Science. 48: 1844-52. PMID 17389520 DOI: 10.1167/Iovs.05-1570 |
0.637 |
|
| 2007 |
Leonard JN, Ferstl P, Delgado A, Schaffer DV. Enhanced preparation of adeno-associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus. Biotechnology and Bioengineering. 97: 1170-9. PMID 17252611 DOI: 10.1002/Bit.21355 |
0.618 |
|
| 2007 |
Saha K, Irwin EF, Kozhukh J, Schaffer DV, Healy KE. Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Journal of Biomedical Materials Research. Part A. 81: 240-9. PMID 17236216 DOI: 10.1002/Jbm.A.30986 |
0.615 |
|
| 2006 |
Koerber JT, Maheshri N, Kaspar BK, Schaffer DV. Construction of diverse adeno-associated viral libraries for directed evolution of enhanced gene delivery vehicles. Nature Protocols. 1: 701-6. PMID 17406299 DOI: 10.1038/Nprot.2006.93 |
0.797 |
|
| 2006 |
Greenberg KP, Lee ES, Schaffer DV, Flannery JG. Gene delivery to the retina using lentiviral vectors. Advances in Experimental Medicine and Biology. 572: 255-66. PMID 17249582 DOI: 10.1007/0-387-32442-9_36 |
0.621 |
|
| 2006 |
Yu JH, Schaffer DV. High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cells. Journal of Virology. 80: 8981-8. PMID 16940510 DOI: 10.1128/Jvi.00615-06 |
0.617 |
|
| 2006 |
Jang JH, Schaffer DV. Microarraying the cellular microenvironment. Molecular Systems Biology. 2: 39. PMID 16820780 DOI: 10.1038/Msb4100079 |
0.41 |
|
| 2006 |
Yu JH, Schaffer DV. Selection of novel vesicular stomatitis virus glycoprotein variants from a peptide insertion library for enhanced purification of retroviral and lentiviral vectors. Journal of Virology. 80: 3285-92. PMID 16537595 DOI: 10.1128/Jvi.80.7.3285-3292.2006 |
0.587 |
|
| 2006 |
Saha K, Schaffer DV. Signal dynamics in Sonic hedgehog tissue patterning. Development (Cambridge, England). 133: 889-900. PMID 16452094 DOI: 10.1242/Dev.02254 |
0.556 |
|
| 2006 |
Maheshri N, Koerber JT, Kaspar BK, Schaffer DV. Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nature Biotechnology. 24: 198-204. PMID 16429148 DOI: 10.1038/Nbt1182 |
0.807 |
|
| 2006 |
Abranches E, O'Neill A, Robertson MJ, Schaffer DV, Cabral JM. Development of quantitative PCR methods to analyse neural progenitor cell culture state. Biotechnology and Applied Biochemistry. 44: 1-8. PMID 16336211 DOI: 10.1042/Ba20050218 |
0.72 |
|
| 2006 |
Leonard JN, Schaffer DV. Antiviral RNAi therapy: emerging approaches for hitting a moving target. Gene Therapy. 13: 532-40. PMID 16177819 DOI: 10.1038/Sj.Gt.3302645 |
0.629 |
|
| 2006 |
Yu JH, Schaffer DV. 736. Engineering Enhanced Retroviral and Lentiviral Vectors through the Selection of Peptide Insertion Libraries Molecular Therapy. 13: S284-S285. DOI: 10.1016/J.Ymthe.2006.08.817 |
0.601 |
|
| 2006 |
Koerber JT, Jang Jang J, Yu J, Kane R, Schaffer DV. 507. Engineering a Novel AAV Variant for Purification Via Immobilized Metal Affinity Chromatography Molecular Therapy. 13: S196. DOI: 10.1016/J.Ymthe.2006.08.577 |
0.709 |
|
| 2005 |
Yu JH, Schaffer DV. Advanced targeting strategies for murine retroviral and adeno-associated viral vectors. Advances in Biochemical Engineering/Biotechnology. 99: 147-67. PMID 16568891 DOI: 10.1007/10_006 |
0.608 |
|
| 2005 |
Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell. 122: 169-82. PMID 16051143 DOI: 10.1016/J.Cell.2005.06.006 |
0.645 |
|
| 2005 |
Lee GK, Maheshri N, Kaspar B, Schaffer DV. PEG conjugation moderately protects adeno-associated viral vectors against antibody neutralization. Biotechnology and Bioengineering. 92: 24-34. PMID 15937953 DOI: 10.1002/Bit.20562 |
0.78 |
|
| 2005 |
Agrawal S, Schaffer DV. In situ stem cell therapy: novel targets, familiar challenges. Trends in Biotechnology. 23: 78-83. PMID 15661344 DOI: 10.1016/J.Tibtech.2004.12.004 |
0.613 |
|
| 2005 |
Leonard JN, Schaffer DV. Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape. Journal of Virology. 79: 1645-54. PMID 15650190 DOI: 10.1128/Jvi.79.3.1645-1654.2005 |
0.625 |
|
| 2005 |
Koerber JT, Maheshri N, Kaspar B, Schaffer DV. 1085. Directed Evolution of AAV2 Leads to Improved Viral Function Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.632 |
0.804 |
|
| 2005 |
Leonard JN, Schaffer DV. 1002. Therapeutic Design Principles for Achieving Long-Term Suppression of HIV-1 with RNA Interference Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.549 |
0.601 |
|
| 2005 |
Leonard JN, Schaffer DV, Ferstl P, Delgado A. 519. Selective Inactivation of Helper Adenovirus with High Hydrostatic Pressure for AAV-2 Vector Production Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.059 |
0.607 |
|
| 2005 |
Yu JH, Schaffer DV. 488. Engineering Enhanced Retroviral Vectors through the Insertion of a His6 Tag into VSV-G Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.028 |
0.595 |
|
| 2005 |
Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. Stochastic gene expression in a lentiviral positive feedback loop: HIV-1 tat fluctuations drive phenotypic diversity Aiche Annual Meeting, Conference Proceedings. 10416. |
0.583 |
|
| 2005 |
Leonard JN, Schaffer DV. Computational design of RNA interference gene therapy strategies to treat HIV-1 infections and block viral escape Aiche Annual Meeting, Conference Proceedings. 8356-8357. |
0.53 |
|
| 2005 |
Koerber JT, Maheshri N, Schaffer DV. Directed evolution of Aav to generate mutants with enhanced transport properties Aiche Annual Meeting, Conference Proceedings. 8565. |
0.765 |
|
| 2005 |
Yu JH, Schaffer DV. Engineering enhanced retroviral vectors for gene therapy Through the generation and selection of 6xhis peptide insertion libraries into Vsv-G Aiche Annual Meeting, Conference Proceedings. 8084. |
0.483 |
|
| 2005 |
Leonard JN, Ferstl P, Delgado A, Schaffer DV. Purification of Aav gene therapy vectors by selectively inactivating helper adenovirus using high hydrostatic pressure Aiche Annual Meeting, Conference Proceedings. 12143. |
0.537 |
|
| 2004 |
Schaffer DV, O'Neill A, Hochrein L, McGranahan T. Quantitative analysis of signaling mechanisms controlling adult neural progenitor cell proliferation. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 7: 4965. PMID 17271428 DOI: 10.1109/IEMBS.2004.1404372 |
0.577 |
|
| 2004 |
Schaffer DV, Maheshri N. Directed evolution of AAV mutants for enhanced gene delivery. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 5: 3520-3. PMID 17271049 DOI: 10.1109/IEMBS.2004.1403990 |
0.779 |
|
| 2004 |
O'Neill A, Schaffer DV. The biology and engineering of stem-cell control. Biotechnology and Applied Biochemistry. 40: 5-16. PMID 15270702 DOI: 10.1042/Ba20030195 |
0.641 |
|
| 2004 |
Ignowski JM, Schaffer DV. Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells. Biotechnology and Bioengineering. 86: 827-34. PMID 15162459 DOI: 10.1002/Bit.20059 |
0.795 |
|
| 2004 |
Lai K, Robertson MJ, Schaffer DV. The sonic hedgehog signaling system as a bistable genetic switch. Biophysical Journal. 86: 2748-57. PMID 15111393 DOI: 10.1016/S0006-3495(04)74328-3 |
0.706 |
|
| 2004 |
Schaffer DV, Gage FH. Neurogenesis and neuroadaptation. Neuromolecular Medicine. 5: 1-9. PMID 15001808 DOI: 10.1385/Nmm:5:1:001 |
0.472 |
|
| 2004 |
Yu JH, Schaffer DV. 725. Engineering Enhanced Retroviral Vectors by Random Insertion of Functional Peptides Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.654 |
0.595 |
|
| 2004 |
Leonard JN, Schaffer DV. 547. Antiviral RNA Interference Strategies That Resist HIV Escape Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.463 |
0.595 |
|
| 2004 |
Lee GK, Schaffer DV. 401. Engineering Retroviral Vectors for Stem Cell Therapies-Overcoming the Effect of Gene Silencing Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.350 |
0.655 |
|
| 2004 |
Maheshri N, Kaspar B, Schaffer DV. 20. Directed Evolution of AAV2 Yields Novel Capsid Variants Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.101 |
0.821 |
|
| 2003 |
Weinberger LS, Schaffer DV, Arkin AP. Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection. Journal of Virology. 77: 10028-36. PMID 12941913 DOI: 10.1128/Jvi.77.18.10028-10036.2003 |
0.543 |
|
| 2003 |
Maheshri N, Schaffer DV. Computational and experimental analysis of DNA shuffling. Proceedings of the National Academy of Sciences of the United States of America. 100: 3071-6. PMID 12626764 DOI: 10.1073/Pnas.0537968100 |
0.715 |
|
| 2003 |
Lai K, Kaspar BK, Gage FH, Schaffer DV. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nature Neuroscience. 6: 21-7. PMID 12469128 DOI: 10.1038/Nn983 |
0.81 |
|
| 2002 |
Lee G, Schaffer D. Engineering the surface properties of synthetic gene delivery vectors Somatic Cell and Molecular Genetics. 27: 17-25. PMID 12774938 DOI: 10.1023/A:1022940100090 |
0.589 |
|
| 2002 |
Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee KF, Heinemann SF, Gage FH. Adeno-associated virus effectively mediates conditional gene modification in the brain. Proceedings of the National Academy of Sciences of the United States of America. 99: 2320-5. PMID 11842206 DOI: 10.1073/Pnas.042678699 |
0.809 |
|
| 2002 |
Kaspar BK, Erickson D, Schaffer D, Hinh L, Gage FH, Peterson DA. Targeted retrograde gene delivery for neuronal protection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 50-6. PMID 11786045 DOI: 10.1006/mthe.2001.0520 |
0.771 |
|
| 2000 |
Schaffer DV, Lauffenburger DA. Targeted synthetic gene delivery vectors. Current Opinion in Molecular Therapeutics. 2: 155-61. PMID 11249636 |
0.468 |
|
| 2000 |
Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnology and Bioengineering. 67: 598-606. PMID 10649234 DOI: 10.1002/(Sici)1097-0290(20000305)67:5<598::Aid-Bit10>3.0.Co;2-G |
0.531 |
|
| 1999 |
Lauffenburger DA, Schaffer DV. The matrix delivers. Nature Medicine. 5: 733-4. PMID 10395312 DOI: 10.1038/10451 |
0.405 |
|
| 1998 |
Schaffer DV, Lauffenburger DA. Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery. The Journal of Biological Chemistry. 273: 28004-9. PMID 9774415 DOI: 10.1074/Jbc.273.43.28004 |
0.522 |
|
| 1997 |
Schaffer DV, Neve RL, Lauffenburger DA. Use of the green fluorescent protein as a quantitative reporter of epidermal growth factor receptor-mediated gene delivery Tissue Engineering. 3: 53-63. DOI: 10.1089/Ten.1997.3.53 |
0.489 |
|
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