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Mark T. Gladwin, M.D. - Publications

Affiliations: 
2008 NIH/NHLBI, Bethesda, MD, United States 
 2008- University of Pittsburgh, Pittsburgh, PA, United States 
Area:
NO
Website:
https://www.vmi.pitt.edu/faculty/gladwin.html
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Year Citation  Score
2024 Gladwin MT, Gordeuk VR, Desai PC, Minniti C, Novelli EM, Morris CR, Ataga KI, De Castro L, Curtis SA, El Rassi F, Ford HJ, Harrington T, Klings ES, Lanzkron S, Liles D, et al. Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1-2 trial. The Lancet. Haematology. PMID 38554715 DOI: 10.1016/S2352-3026(24)00045-0  0.591
2023 DeMartino AW, Poudel L, Dent MR, Chen X, Xu Q, Gladwin BS, Tejero J, Basu S, Alipour E, Jiang Y, Rose JJ, Gladwin MT, Kim-Shapiro DB. Thiol-catalyzed formation of NO-ferroheme regulates intravascular NO signaling. Nature Chemical Biology. PMID 37710075 DOI: 10.1038/s41589-023-01413-3  0.648
2023 Dent MR, Rose JJ, Tejero J, Gladwin MT. Carbon Monoxide Poisoning: From Microbes to Therapeutics. Annual Review of Medicine. PMID 37582490 DOI: 10.1146/annurev-med-052422-020045  0.613
2023 DeMartino A, Poudel L, Dent M, Chen X, Xu Q, Gladwin B, Tejero J, Basu S, Alipour E, Jiang Y, Rose J, Gladwin M, Kim-Shapiro D. Thiol catalyzed formation of NO-ferroheme regulates canonical intravascular NO signaling. Research Square. PMID 36711928 DOI: 10.21203/rs.3.rs-2402224/v1  0.65
2022 Xu Q, Rose JJ, Chen X, Wang L, DeMartino AW, Dent MR, Tiwari S, Bocian K, Huang XN, Tong Q, McTiernan CF, Guo L, Alipour E, Jones TC, Ucer KB, ... ... Gladwin MT, et al. Cell-free and alkylated hemoproteins improve survival in mouse models of carbon monoxide poisoning. Jci Insight. PMID 36173682 DOI: 10.1172/jci.insight.153296  0.612
2021 Johnson S, Gordeuk VR, Machado R, Gibbs JSR, Hildesheim M, Little JA, Kato GJ, Gladwin MT, Nouraie M. Exercise Induced Changes of Vital Signs in Adults with Sickle Cell Disease. American Journal of Hematology. PMID 34626431 DOI: 10.1002/ajh.26369  0.613
2021 Dent MR, DeMartino AW, Tejero J, Gladwin MT. Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite. Inorganic Chemistry. PMID 34313417 DOI: 10.1021/acs.inorgchem.1c01048  0.64
2021 Satoh T, Wang L, Espinosa-Diez C, Wang B, Hahn SA, Noda K, Rochon ER, Dent MR, Levine A, Baust JJ, Wyman S, Wu YL, Triantafyllou GA, Tang Y, Reynolds M, ... ... Gladwin MT, et al. Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Down Regulation of sGC and Contributes to Exercise-Induced Pulmonary Hypertension in HFpEF. Circulation. PMID 34157861 DOI: 10.1161/CIRCULATIONAHA.121.053889  0.622
2020 Novelli EM, Moon CH, Pham TA, Perkins LA, Little-Ihrig L, Tavakoli S, Mason NS, Lang L, Chen X, Laymon CM, Gladwin MT, Anderson CJ. First report of Ga-PRGD2 PET/MRI molecular imaging of vaso-occlusion in a patient with sickle cell disease. Bjr Case Reports. 6: 20200024. PMID 33299586 DOI: 10.1259/Bjrcr.20200024  0.305
2020 DeMartino AW, Rose JJ, Amdahl MB, Dent MR, Shah FA, Bain W, McVerry BJ, Kitsios GD, Tejero J, Gladwin MT. No evidence of hemoglobin damage by SARS-CoV-2 infection. Haematologica. PMID 33054129 DOI: 10.3324/Haematol.2020.264267  0.661
2020 Nouraie M, Ashley-Koch AE, Garrett ME, Sritharan N, Zhang Y, Little J, Gordeuk VR, Gladwin MT, Telen MJ, Kato GJ. Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts. Plos One. 15: e0237543. PMID 32776978 DOI: 10.1371/Journal.Pone.0237543  0.61
2020 Hughan KS, Levine A, Helbling N, Anthony S, DeLany JP, Stefanovic-Racic M, Goodpaster BH, Gladwin MT. Effects of Oral Sodium Nitrite on Blood Pressure, Insulin Sensitivity, and Intima-Media Arterial Thickening in Adults With Hypertension and Metabolic Syndrome. Hypertension (Dallas, Tex. : 1979). 76: 866-874. PMID 32755471 DOI: 10.1161/Hypertensionaha.120.14930  0.323
2020 Gordeuk VR, Shah BN, Zhang X, Thuma PE, Zulu S, Moono R, Reading NS, Song J, Zhang Y, Nouraie M, Campbell A, Minniti CP, Rana SR, Darbari DS, Kato GJ, ... ... Gladwin MT, et al. CYB5R3 and G6PD A Alleles Modify Severity of Anemia in Malaria and Sickle Cell Disease. American Journal of Hematology. PMID 32697331 DOI: 10.1002/Ajh.25941  0.337
2020 Brzoska T, Vats R, Bennewitz MF, Tutuncuoglu E, Watkins SC, Ragni MV, Neal MD, Gladwin MT, Sundd P. Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in pre-capillary pulmonary arterioles. Jci Insight. PMID 32544100 DOI: 10.1172/Jci.Insight.139437  0.351
2020 George MP, Gladwin MT, Graham BB. Exploring New Therapeutic Pathways in Pulmonary Hypertension: Metabolism, Proliferation, and Personalized Medicine. American Journal of Respiratory Cell and Molecular Biology. PMID 32453969 DOI: 10.1165/Rcmb.2020-0099Tr  0.318
2020 Bashline MJ, Bachman TN, Helbling NL, Nouraie M, Gladwin MT, Simon MA. The Effects of Inhaled Sodium Nitrite on Pulmonary Vascular Impedance in Patients with Pulmonary Hypertension Associated with HFpEF. Journal of Cardiac Failure. PMID 32446946 DOI: 10.1016/J.Cardfail.2020.04.006  0.344
2020 Goncharova EA, Chan SY, Ventetuolo CE, Weissmann N, Schermuly RT, Mullin CJ, Gladwin MT. Update in Pulmonary Vascular Diseases and Right Ventricular Dysfunction in 2019. American Journal of Respiratory and Critical Care Medicine. PMID 32311291 DOI: 10.1164/Rccm.202003-0576Up  0.327
2020 Wang L, Halliday G, Huot JR, Satoh T, Baust JJ, Fisher A, Cook T, Hu J, Avolio T, Goncharov DA, Bai Y, Vanderpool RR, Considine RV, Bonetto A, Tan J, ... ... Gladwin MT, et al. Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119313883. PMID 32268788 DOI: 10.1161/Atvbaha.119.313883  0.31
2020 Nouraie M, Darbari DS, Rana S, Minniti CP, Castro OL, Luchtman Jones L, Sable C, Dham N, Kato GJ, Gladwin MT, Ensing G, Arteta M, Campbell A, Taylor JG, Nekhai S, et al. Tricuspid Regurgitation Velocity and Other Biomarkers of Mortality in Children, Adolescents and Young Adults with Sickle Cell Disease in the United States: the PUSH Study. American Journal of Hematology. PMID 32243618 DOI: 10.1002/Ajh.25799  0.334
2020 D'Alessandro A, Fu X, Kanias T, Reisz JA, Culp-Hill R, Guo Y, Gladwin MT, Page G, Kleinman S, Lanteri M, Stone M, Busch MP, Zimring JC. Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity. Haematologica. PMID 32241843 DOI: 10.3324/Haematol.2020.246603  0.345
2020 Rose JJ, Bocian KA, Xu Q, Wang L, DeMartino AW, Chen X, Corey CG, Guimarães DA, Azarov I, Huang XN, Tong Q, Guo L, Nouraie M, McTiernan CF, O'Donnell CP, ... ... Gladwin M, et al. A neuroglobin-based hig-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning. The Journal of Biological Chemistry. PMID 32205448 DOI: 10.1074/Jbc.Ra119.010593  0.328
2020 Nouraie M, Zhang X, Srisuwananukorn A, Machado RF, Gordeuk VR, Gladwin MT, Saraf S. Potential Contribution of Pulmonary Thromboembolic Disease in Pulmonary Hypertension in Sickle Cell Disease. Annals of the American Thoracic Society. PMID 32187498 DOI: 10.1513/Annalsats.201911-840Rl  0.36
2020 Rochon ER, Krowka MJ, Bartolome S, Heresi GA, Bull T, Roberts K, Hemnes A, Forde KA, Krok KL, Patel M, Lin G, McNeil M, Al-Naamani N, Roman BL, Yu PB, ... ... Gladwin MT, et al. BMP 9/10 in Pulmonary Vascular Complications of Liver Disease. American Journal of Respiratory and Critical Care Medicine. PMID 32083953 DOI: 10.1164/Rccm.201912-2514Le  0.308
2020 Kumar A, Noda K, Philips B, Velayutham M, Stolz DB, Gladwin MT, Shiva S, D'Cunha J. Nitrite Attenuates Mitochondrial Impairment And Vascular Permeability Induced by Ischemia-Reperfusion Injury in Lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 32073901 DOI: 10.1152/Ajplung.00367.2018  0.313
2019 Wood K, Gladwin M, Straub A. Sickle cell disease: at the crossroads of pulmonary hypertension and diastolic heart failure. Heart (British Cardiac Society). PMID 31822569 DOI: 10.1136/Heartjnl-2019-314810  0.363
2019 Wood KC, Durgin BG, Schmidt HM, Hahn SA, Baust JJ, Bachman T, Vitturi DA, Ghosh S, Ofori-Acquah SF, Mora AL, Gladwin MT, Straub AC. Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice. Blood Advances. 3: 4104-4116. PMID 31821458 DOI: 10.1182/Blood-2019-124159  0.393
2019 Farrell AT, Panepinto J, Desai AA, Kassim AA, Lebensburger J, Walters MC, Bauer DE, Blaylark RM, DiMichele DM, Gladwin MT, Green NS, Hassell K, Kato GJ, Klings ES, Kohn DB, et al. End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings. Blood Advances. 3: 4002-4020. PMID 31809537 DOI: 10.1182/Bloodadvances.2019000883  0.591
2019 Zhang X, Shah BN, Zhang W, Saraf SL, Nouraie M, Nekhai S, Machado RF, Gladwin MT, Gordeuk VR. S100B has pleiotropic effects on vaso-occlusive manifestations in sickle cell disease. American Journal of Hematology. PMID 31805207 DOI: 10.1002/Ajh.25691  0.321
2019 Amdahl MB, DeMartino AW, Gladwin MT. Inorganic nitrite bioactivation and role in physiological signaling and therapeutics. Biological Chemistry. 401: 201-211. PMID 31747370 DOI: 10.1515/Hsz-2019-0349  0.361
2019 Wang L, Sparacino-Watkins CE, Wang J, Wajih N, Varano P, Xu Q, Cecco E, Tejero J, Soleimani M, Kim-Shapiro DB, Gladwin MT. Carbonic Anhydrase II Does Not Regulate Nitrite Dependent Nitric Oxide Formation and Vasodilation. British Journal of Pharmacology. PMID 31658361 DOI: 10.1111/Bph.14887  0.318
2019 Vats R, Brzoska T, Bennewitz MF, Jimenez MA, Pradhan-Sundd T, Tutuncuoglu E, Jonassaint J, Gutierrez E, Watkins SC, Shiva S, Scott M, Morelli AE, Neal MD, Kato GJ, Gladwin MT, et al. Platelet Extracellular Vesicles Drive Inflammasome-IL1β-dependent Lung Injury in Sickle Cell Disease. American Journal of Respiratory and Critical Care Medicine. PMID 31498653 DOI: 10.1164/Rccm.201807-1370Oc  0.315
2019 Ruhl AP, Sadreameli SC, Allen JL, Bennett DP, Campbell AD, Coates TD, Diallo DA, Field JJ, Fiorino EK, Gladwin MT, Glassberg JA, Gordeuk VR, Graham LM, Greenough A, Howard J, et al. Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report. Annals of the American Thoracic Society. 16: e17-e32. PMID 31469310 DOI: 10.1513/Annalsats.201906-433St  0.345
2019 Nouraie M, Little JA, Hildesheim M, Gibbs JSR, Morris CR, Machado RF, Kato GJ, Gordeuk VR, Gladwin MT. Validation of a composite vascular high risk profile for adult patients with sickle cell disease. American Journal of Hematology. PMID 31444803 DOI: 10.1002/Ajh.25624  0.599
2019 Donnenberg AD, Kanias T, Triulzi DJ, Dennis CJ, Meyer EM, Gladwin M. Improved quantitative detection of biotin-labeled red blood cells by flow cytometry. Transfusion. PMID 31172532 DOI: 10.1111/Trf.15354  0.309
2019 Donnenberg AD, Kanias T, Triulzi DJ, Dennis CJ, Moore LR, Meyer EM, Sinchar D, Kiss JE, Normolle DP, Gladwin MT. Current good manufacturing practices-compliant manufacture and measurement of biotin-labeled red blood cells. Cytotherapy. PMID 31097327 DOI: 10.1016/J.Jcyt.2019.04.052  0.323
2019 Novelli EM, Little-Ihrig L, Knupp HE, Rogers NM, Yao M, Baust JJ, Meijles D, St Croix CM, Ross MA, Pagano PJ, DeVallance ER, Miles G, Potoka KP, Isenberg JS, Gladwin MT. Vascular TSP1-CD47 Signaling Promotes Sickle Cell-Associated Arterial Vasculopathy and Pulmonary Hypertension in Mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30892078 DOI: 10.1152/Ajplung.00302.2018  0.347
2019 D'Alessandro A, Reisz JA, Zhang Y, Gehrke S, Alexander K, Kanias T, Triulzi DJ, Donadee C, Barge S, Badlam J, Jain S, Risbano MG, Gladwin MT. Effects of aged stored autologous red blood cells on human plasma metabolome. Blood Advances. 3: 884-896. PMID 30890545 DOI: 10.1182/Bloodadvances.2018029629  0.355
2019 de Jesus DS, DeVallance E, Li Y, Falabella M, Guimaraes D, Shiva S, Kaufman BA, Gladwin MT, Pagano PJ. Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration. Redox Biology. 22: 101138. PMID 30802716 DOI: 10.1016/J.Redox.2019.101138  0.348
2019 Tejero J, Shiva S, Gladwin MT. Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation Physiological Reviews. 99: 311-379. PMID 30379623 DOI: 10.1152/Physrev.00036.2017  0.381
2019 Sundd P, Gladwin MT, Novelli EM. Pathophysiology of Sickle Cell Disease. Annual Review of Pathology. 14: 263-292. PMID 30332562 DOI: 10.1146/Annurev-Pathmechdis-012418-012838  0.335
2019 Brzoska T, Tutuncuoglu E, Tofovic SP, Jackson EK, Gladwin MT, Sundd P. CD39 As a Master Regulator of Pulmonary Thrombosis in Sickle Cell Disease Blood. 134: 2266-2266. DOI: 10.1182/Blood-2019-130882  0.357
2019 Brzoska T, Bennewitz MF, Tutuncuoglu E, Ragni MV, Neal MD, Gladwin MT, Sundd P. Mechanism of Pulmonary Thrombosis in Hemolytic Disorders Blood. 134: 976-976. DOI: 10.1182/Blood-2019-130592  0.365
2019 Vats R, Tutuncuoglu E, Tejero J, Hillery CA, Gladwin MT, Sundd P. Circulating Neutrophil Extracellular Traps in the Pathogenesis of Acute Chest Syndrome of Sickle Cell Disease Blood. 134: 3556-3556. DOI: 10.1182/Blood-2019-130574  0.308
2019 Mensah M, Shah BN, Zhang X, Han J, Gowhari M, Molokie RE, Gladwin MT, Gordeuk VR, Saraf SL. Risk Factors for Kidney Disease in Hb SC and Hb Sβ+-Thalassemia Sickle Cell Disease Blood. 134: 2299-2299. DOI: 10.1182/Blood-2019-128668  0.332
2019 Wang L, Zuchelkowski B, Sinchar D, Yang M, Gingras S, Kanias T, Lee JS, Kim-Shapiro D, Page G, Gladwin MT. Evaluation of the Functional Effects of an African American Glucose-6-Phosphate Dehydrogenase (G6PD) Polymorphism (Val68Met) on RBC Hemolytic Propensity and Post-Transfusion Recovery in a Humanized Mouse Model Blood. 134: 102-102. DOI: 10.1182/Blood-2019-124926  0.348
2019 Saraf SL, Derebail VK, Zhang X, Gladwin MT, Gordeuk VR, Little JA. Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia Blood. 134: 2268-2268. DOI: 10.1182/Blood-2019-124737  0.585
2019 Simon M, Gomberg-Maitland M, Oudiz R, Machado R, Rischard F, Elinoff J, Grigorian B, Schmid A, Hou S, Desai N, Gladwin M. Patients With Severe Pulmonary Arterial Hypertension Treated With Abi-009, Nab-Sirolimus, An Mtor Inhibitor: Interim Results From A Phase 1 Clinical Trial Journal of the American College of Cardiology. 73: 1927. DOI: 10.1016/S0735-1097(19)32533-1  0.308
2018 Lai YC, Wang L, Gladwin MT. Insights into the Pulmonary Vascular complications of heart failure with Preserved Ejection Fraction. The Journal of Physiology. PMID 30549058 DOI: 10.1113/Jp275858  0.337
2018 Kanias T, Stone M, Page GP, Guo Y, Endres-Dighe SM, Lanteri MC, Spencer BR, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Gladwin MT, Busch MP, Mast AE, et al. Frequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis. Transfusion. PMID 30474858 DOI: 10.1111/Trf.14998  0.32
2018 Wajih N, Basu S, Ucer KB, Rigal F, Shakya A, Rahbar E, Vachharajani V, Guthold M, Gladwin MT, Smith LM, Kim-Shapiro DB. Erythrocytic bioactivation of nitrite and its potentiation by far-red light. Redox Biology. 20: 442-450. PMID 30423533 DOI: 10.1016/J.Redox.2018.11.001  0.322
2018 Lanteri MC, Kanias T, Keating S, Stone M, Guo Y, Page GP, Brambilla DJ, Endres-Dighe SM, Mast AE, Bialkowski W, D'Andrea P, Cable RG, Spencer BR, Triulzi DJ, Murphy EL, ... ... Gladwin MT, et al. Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study. Transfusion. PMID 30408207 DOI: 10.1111/Trf.14987  0.318
2018 D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, et al. Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics. Transfusion. PMID 30353560 DOI: 10.1111/Trf.14979  0.309
2018 Endres-Dighe SM, Guo Y, Kanias T, Lanteri M, Stone M, Spencer B, Cable RG, Kiss JE, Kleinman S, Gladwin MT, Brambilla DJ, D'Andrea P, Triulzi DJ, Mast AE, Page GP, et al. Blood, sweat, and tears: Red Blood Cell-Omics study objectives, design, and recruitment activities. Transfusion. PMID 30267427 DOI: 10.1111/Trf.14971  0.318
2018 Remy KE, Cortés-Puch I, Solomon SB, Sun J, Pockros BM, Feng J, Lertora JJ, Hantgan RR, Liu X, Perlegas A, Warren HS, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Haptoglobin improves shock, lung injury, and survival in canine pneumonia. Jci Insight. 3. PMID 30232287 DOI: 10.1172/Jci.Insight.123013  0.339
2018 Levine AR, Simon MA, Gladwin MT. Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction. Trends in Cardiovascular Medicine. PMID 30177249 DOI: 10.1016/J.Tcm.2018.08.005  0.338
2018 DeMartino AW, Kim-Shapiro D, Patel RP, Gladwin MT. Nitrite and nitrate chemical biology and signaling. British Journal of Pharmacology. PMID 30152056 DOI: 10.1111/Bph.14484  0.362
2018 Bilan V, Schneider F, Novelli EM, Kelley EE, Sriva S, Gladwin M, Jackson EK, Tofovic SP. EXPRESS: Experimental Intravascular Hemolysis Induces Hemodynamic and Pathological Pulmonary Hypertension - Association with Accelerated Purine Metabolism. Pulmonary Circulation. 2045894018791557. PMID 30003836 DOI: 10.1177/2045894018791557  0.324
2018 Du M, Van Ness S, Gordeuk V, Nouraie SM, Nekhai S, Gladwin M, Steinberg MH, Sebastiani P. Biomarker signatures of sickle cell disease severity. Blood Cells, Molecules & Diseases. PMID 29778312 DOI: 10.1016/j.bcmd.2018.05.001  0.35
2018 Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC. Metformin Therapy for Pulmonary Hypertension Associated with HFpEF versus PAH. American Journal of Respiratory and Critical Care Medicine. PMID 29727194 DOI: 10.1164/Rccm.201801-0022Le  0.314
2018 Kim-Shapiro DB, Gladwin MT. Nitric oxide pathology and therapeutics in sickle cell disease. Clinical Hemorheology and Microcirculation. 68: 223-237. PMID 29614634 DOI: 10.3233/Ch-189009  0.42
2018 Huertas A, Guignabert C, Barberà JA, Bärtsch P, Bhattacharya J, Bhattacharya S, Bonsignore MR, Dewachter L, Dinh-Xuan AT, Dorfmüller P, Gladwin MT, Humbert M, Kotsimbos T, Vassilakopoulos T, Sanchez O, et al. Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to therapy. The European Respiratory Journal. 51. PMID 29545281 DOI: 10.1183/13993003.00745-2017  0.346
2018 Vanderpool RR, Saul M, Nouraie M, Gladwin MT, Simon MA. Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction. Jama Cardiology. PMID 29541759 DOI: 10.1001/Jamacardio.2018.0128  0.31
2018 Helms CC, Gladwin MT, Kim-Shapiro DB. Erythrocytes and Vascular Function: Oxygen and Nitric Oxide. Frontiers in Physiology. 9: 125. PMID 29520238 DOI: 10.3389/Fphys.2018.00125  0.413
2018 Hensley MK, Levine A, Gladwin MT, Lai YC. Emerging Therapeutics in Pulmonary Hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 29388467 DOI: 10.1152/Ajplung.00259.2017  0.341
2018 Maron BA, Brittain EL, Choudhary G, Gladwin MT. Redefining pulmonary hypertension. The Lancet. Respiratory Medicine. 6: 168-170. PMID 29269004 DOI: 10.1016/S2213-2600(17)30498-8  0.313
2018 HUGHAN KS, HELBLING NL, ANTHONY SJ, DELANY J, GOODPASTER BH, GLADWIN M. Oral Sodium Nitrite Improves Insulin Sensitivity, Blood Pressure, and Arterial Thickening in Adults with Uncontrolled Hypertension and Metabolic Syndrome Diabetes. 67: 75-OR. DOI: 10.2337/Db18-75-Or  0.339
2018 DeMartino A, Tejero J, Gladwin M. Interrogating the cytoglobin binding pocket and thiol redox status with point mutations and chemical probes Free Radical Biology and Medicine. 128. DOI: 10.1016/J.Freeradbiomed.2018.10.086  0.317
2018 Velayutham M, Cecco E, Shiva S, Gladwin M, Sparacino-Watkins C. Generation of superoxide radical by human cytochrome b5 reductase is modulated by cytochrome b5 Free Radical Biology and Medicine. 128. DOI: 10.1016/J.Freeradbiomed.2018.10.064  0.317
2017 Potoka KP, Wood KC, Baust JJ, Bueno M, Hahn SA, Vanderpool RR, Bachman T, Mallampalli GM, Osei-Hwedieh DO, Schrott V, Sun B, Bullock GC, Becker-Pelster EM, Wittwer M, Stampfuss J, ... ... Gladwin MT, et al. NO-independent sGC Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease. American Journal of Respiratory Cell and Molecular Biology. PMID 29268036 DOI: 10.1165/Rcmb.2017-0292Oc  0.391
2017 Willen SM, Gladwin MT. What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease? Hematology. American Society of Hematology. Education Program. 2017: 431-434. PMID 29222289 DOI: 10.1182/Asheducation-2017.1.431  0.341
2017 Gladwin MT. Cardiovascular complications in patients with sickle cell disease. Hematology. American Society of Hematology. Education Program. 2017: 423-430. PMID 29222288 DOI: 10.1182/Asheducation-2017.1.423  0.383
2017 Rochon ER, Corti P, Gladwin MT. Hemoglobin α in Pulmonary Endothelium: Ironing Out Nitric Oxide Signaling. American Journal of Respiratory Cell and Molecular Biology. 57: 639-641. PMID 29192832 DOI: 10.1165/Rcmb.2017-0272Ed  0.325
2017 Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ. The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. Science Signaling. 10. PMID 29042481 DOI: 10.1126/Scisignal.Aaj1784  0.344
2017 Kanias T, Lanteri MC, Page GP, Guo Y, Endres SM, Stone M, Keating S, Mast AE, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Busch MP, Gladwin MT. Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study. Blood Advances. 1: 1132-1141. PMID 29034365 DOI: 10.1182/Bloodadvances.2017004820  0.316
2017 Amdahl MB, DeMartino AW, Tejero J, Gladwin MT. Cytoglobin at the Crossroads of Vascular Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 37: 1803-1805. PMID 28954806 DOI: 10.1161/Atvbaha.117.310058  0.366
2017 Dutta P, Gomez D, Gladwin MT. Do BRD(4)S of a Feather Flock Together? How an Inflammation-Driven Epigenetic Regulator May Link Pulmonary Hypertension and Coronary Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 37: 1428-1430. PMID 28747456 DOI: 10.1161/Atvbaha.117.309632  0.311
2017 Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT. Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate. Hypertension (Dallas, Tex. : 1979). PMID 28739973 DOI: 10.1161/Hypertensionaha.117.09016  0.342
2017 Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty C, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC. Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling. Circulation Research. PMID 28584062 DOI: 10.1161/Circresaha.117.310705  0.344
2017 Wajih N, Basu S, Jailwala A, Kim HW, Ostrowski D, Perlegas A, Bolden CA, Buechler NL, Gladwin MT, Caudell DL, Rahbar E, Alexander-Miller MA, Vachharajani V, Kim-Shapiro DB. Potential therapeutic action of nitrite in sickle cell disease. Redox Biology. 12: 1026-1039. PMID 28511346 DOI: 10.1016/J.Redox.2017.05.006  0.38
2017 Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, ... ... Gladwin M, et al. Enhancing Insights into Pulmonary Vascular Disease (PVD) Through a Precision Medicine Approach. A Joint NHLBI-CMREF Workshop Report. American Journal of Respiratory and Critical Care Medicine. PMID 28430547 DOI: 10.1164/Rccm.201701-0150Ws  0.351
2017 Nguyen QL, Corey C, White P, Watson A, Gladwin MT, Simon MA, Shiva S. Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity. Jci Insight. 2: e91415. PMID 28289721 DOI: 10.1172/Jci.Insight.91415  0.354
2017 Kato GJ, Steinberg MH, Gladwin MT. Intravascular hemolysis and the pathophysiology of sickle cell disease. The Journal of Clinical Investigation. 127: 750-760. PMID 28248201 DOI: 10.1172/Jci89741  0.448
2017 Meng Q, Lai YC, Kelly NJ, Bueno M, Baust J, Bachman T, Goncharov D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris A, Mora AL, Shapiro SD, Gladwin MT. Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction (PH-HFpEF). American Journal of Respiratory Cell and Molecular Biology. PMID 28118022 DOI: 10.1165/Rcmb.2016-0177Oc  0.309
2017 Bennewitz MF, Jimenez MA, Vats R, Tutuncuoglu E, Jonassaint J, Kato GJ, Gladwin MT, Sundd P. Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli. Jci Insight. 2: e89761. PMID 28097236 DOI: 10.1172/Jci.Insight.89761  0.339
2017 Gladwin MT. How Red Blood Cells Process Nitric Oxide: Evidence for the Nitrite Hypothesis. Circulation. 135: 177-179. PMID 28069711 DOI: 10.1161/Circulationaha.116.024752  0.393
2017 Gladwin MT. Translational Advances in the Field of Pulmonary Hypertension Bench to Bedside: How Fundamental Discoveries in Science Are Advancing Our Understanding and Therapy of Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 195: 1-3. PMID 28035850 DOI: 10.1164/Rccm.201608-1637Ed  0.313
2017 Makubi A, Mmbando BP, Novelli EM, Lwakatare J, Soka D, Marik H, Tibarazwa K, Ngaeje M, Newton CR, Gladwin MT, Makani J. Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years’ experience British Journal of Haematology. 177: 930-937. PMID 27650269 DOI: 10.1111/Bjh.14330  0.303
2017 Brzoska T, Vats R, Jimenez MA, Tutuncuoglu E, Bennewitz MF, Gladwin MT, Sundd P. Platelet Aggregation Dysfunction in Sickle Cell Disease Blood. 130: 4774-4774. DOI: 10.1182/Blood.V130.Suppl_1.4774.4774  0.334
2017 Rochon E, Xue J, Tejero J, Gladwin M, Corti P. Nitrite improves Zebrafish Cardiac Regeneration Potentially by Cytoglobin 1 Free Radical Biology and Medicine. 112: 122. DOI: 10.1016/J.Freeradbiomed.2017.10.184  0.305
2017 Cecco E, Gladwin MT, Sparacino-Watkins C. Oxygen Inhibits Nitrite Reduction to Nitric Oxide by the Molybdenum-Dependent mARC-2 Enzyme Free Radical Biology and Medicine. 112: 34. DOI: 10.1016/J.Freeradbiomed.2017.10.042  0.335
2017 Amdahl MB, Petersen E, Corti P, Sparacino-Watkins C, Fago A, Gladwin MT, Tejero J. Interactions of zebrafish Cytoglobins with oxygen and nitric oxide Free Radical Biology and Medicine. 112: 19. DOI: 10.1016/J.Freeradbiomed.2017.10.014  0.321
2016 Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, et al. A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease. Human Molecular Genetics. 25: 4601-4609. PMID 28173069 DOI: 10.1093/Hmg/Ddw299  0.332
2016 Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, Zhang Y, Kato GJ. Thrombospondin-1 Gene Polymorphism is Associated with Estimated Pulmonary Artery Pressure in Patients with Sickle Cell Anemia. American Journal of Hematology. PMID 28033687 DOI: 10.1002/Ajh.24635  0.316
2016 Koch CD, Gladwin MT, Freeman BA, Lundberg JO, Weitzberg E, Morris A. Enterosalivary nitrate metabolism and the microbiome: intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health. Free Radical Biology & Medicine. PMID 27989792 DOI: 10.1016/J.Freeradbiomed.2016.12.015  0.38
2016 Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, ... Gladwin MT, et al. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Science Translational Medicine. 8: 368ra173. PMID 27928027 DOI: 10.1126/Scitranslmed.Aah6571  0.348
2016 Simon MA, Vanderpool RR, Nouraie M, Bachman TN, White PM, Sugahara M, Gorcsan J, Parsley EL, Gladwin MT. Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction. Jci Insight. 1: e89620. PMID 27812547 DOI: 10.1172/Jci.Insight.89620  0.302
2016 Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Carbon Monoxide Poisoning: Pathogenesis, Management and Future Directions of Therapy. American Journal of Respiratory and Critical Care Medicine. PMID 27753502 DOI: 10.1164/Rccm.201606-1275Ci  0.332
2016 D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, et al. AltitudeOmics: Red Blood Cell metabolic adaptation to high altitude hypoxia. Journal of Proteome Research. PMID 27646145 DOI: 10.1021/Acs.Jproteome.6B00733  0.32
2016 Osei-Hwedieh DO, Kanias T, Croix CS, Jessup M, Xiong Z, Sinchar D, Franks J, Xu Q, M Novelli E, Sertorio JT, Potoka K, Binder RJ, Basu S, Belanger M, Kim-Shapiro DB, ... ... Gladwin MT, et al. Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice. Ebiomedicine. PMID 27523807 DOI: 10.1016/J.Ebiom.2016.08.006  0.353
2016 Kanias T, Sinchar D, Osei-Hwedieh D, Baust JJ, Jordan A, Zimring JC, Waterman HR, de Wolski KS, Acker JP, Gladwin MT. Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. Transfusion. PMID 27507802 DOI: 10.1111/Trf.13745  0.384
2016 Lai YC, Gladwin MT. Response by Lai and Gladwin to Letter Regarding Article, "SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction". Circulation. 134: e79-80. PMID 27502916 DOI: 10.1161/Circulationaha.116.023201  0.322
2016 Corti P, Xue J, Tejero J, Wajih N, Sun M, Stolz DB, Tsang M, Kim-Shapiro DB, Gladwin MT. Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 27407144 DOI: 10.1073/Pnas.1522670113  0.347
2016 Ahluwalia A, Gladwin M, Coleman GD, Hord N, Howard G, Kim-Shapiro DB, Lajous M, Larsen FJ, Lefer DJ, McClure LA, Nolan BT, Pluta R, Schechter A, Wang CY, Ward MH, et al. Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop. Journal of the American Heart Association. 5. PMID 27385425 DOI: 10.1161/Jaha.116.003402  0.522
2016 Gladwin MT. Cardiovascular complications and risk of death in sickle-cell disease. The Lancet. 387: 2565-2574. PMID 27353687 DOI: 10.1016/S0140-6736(16)00647-4  0.368
2016 Maron BA, Gladwin MT, Simon MA. Update in Pulmonary Vascular Disease 2015. American Journal of Respiratory and Critical Care Medicine. 193: 1337-1344. PMID 27304242 DOI: 10.1164/Rccm.201601-0143Up  0.363
2016 Novelli EM, Gladwin MT. Crises in Sickle Cell Disease Chest. 149: 1082-1093. PMID 26836899 DOI: 10.1016/J.Chest.2015.12.016  0.361
2016 Lai YC, Tabima DM, Dube JJ, Hughan KS, Goncharov DA, Vanderpool RR, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT. SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF). Circulation. PMID 26813102 DOI: 10.1161/Circulationaha.115.018935  0.348
2016 Drawz P, Ayyappan S, Nouraie M, Saraf S, Gordeuk V, Hostetter T, Gladwin MT, Little J. Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC. Clinical Journal of the American Society of Nephrology : Cjasn. 11: 207-15. PMID 26672090 DOI: 10.2215/Cjn.03940415  0.606
2016 Anderson BR, Garrett ME, Soldano KL, Orringer EP, Eckman JR, Francescatto L, Davis EE, Gladwin MT, Gordeuk VR, Telen MJ, Ashley-Koch AE. GWAS Meta-Analysis of Glomerular Filtration Rate in Three Cohorts of Sickle Cell Disease Patients and In Vivo Functional Analysis Reveals Potential Nephropathy Candidate Genes Blood. 128: 269-269. DOI: 10.1182/Blood.V128.22.269.269  0.326
2016 Bennewitz MF, Vats R, Tutuncuoglu E, Gladwin MT, Sundd P. Lung Vaso-Occlusion in Sickle Cell Disease Mediated By Arteriolar Neutrophil-Platelet Micro-Emboli Blood. 128: 159-159. DOI: 10.1182/Blood.V128.22.159.159  0.317
2016 Wajih N, Jailwala A, Gladwin M, Caudell DL, Kim-Shapiro DB. Superior Targeted Anti-Platelet Activity of Nitrite Free Radical Biology and Medicine. 100. DOI: 10.1016/J.Freeradbiomed.2016.10.405  0.306
2015 Hon YY, Lin EE, Tian X, Yang Y, Sun H, Swenson ER, Taveira-DaSilva AM, Gladwin MT, Machado RF. INCREASED CONSUMPTION AND VASODILATORY EFFECT OF NITRITE DURING EXERCISE. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00081.2015. PMID 26684248 DOI: 10.1152/Ajplung.00081.2015  0.305
2015 Rojas M, Mora AL, Kapetanaki M, Weathington N, Gladwin M, Eickelberg O. Aging and Lung Disease. Clinical Impact and Cellular and Molecular Pathways. Annals of the American Thoracic Society. 12: S222-7. PMID 26653202 DOI: 10.1513/Annalsats.201508-484Pl  0.303
2015 Lundberg JO, Gladwin MT, Weitzberg E. Strategies to increase nitric oxide signalling in cardiovascular disease. Nature Reviews. Drug Discovery. 14: 623-41. PMID 26265312 DOI: 10.1038/Nrd4623  0.336
2015 Gladwin MT. Revisiting the hyperhemolysis paradigm. Blood. 126: 695-696. PMID 26251222 DOI: 10.1182/Blood-2015-06-649491  0.356
2015 Feld JJ, Kato GJ, Koh C, Shields T, Hildesheim M, Kleiner DE, Taylor JG, Sandler NG, Douek D, Haynes-Williams V, Nichols JS, Hoofnagle JH, Jake Liang T, Gladwin MT, Heller T. Liver injury is associated with mortality in sickle cell disease. Alimentary Pharmacology & Therapeutics. 42: 912-21. PMID 26235444 DOI: 10.1111/Apt.13347  0.323
2015 Risbano MG, Kanias T, Triulzi D, Donadee C, Barge S, Badlam J, Jain S, Belanger AM, Kim-Shapiro DB, Gladwin MT. Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function. American Journal of Respiratory and Critical Care Medicine. PMID 26222884 DOI: 10.1164/Rccm.201501-0145Oc  0.377
2015 Saraf SL, Zhang X, Shah B, Kanias T, Gudehithlu KP, Kittles R, Machado RF, Arruda J, Gladwin MT, Singh AK, Gordeuk VR. Genetic Variants and Cell-Free Hemoglobin Processing in Sickle Cell Nephropathy. Haematologica. PMID 26206798 DOI: 10.3324/Haematol.2015.124875  0.367
2015 Hu J, Xu Q, McTiernan C, Lai YC, Osei-Hwedieh D, Gladwin M. Novel Targets of Drug Treatment for Pulmonary Hypertension. American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions. 15: 225-34. PMID 26016608 DOI: 10.1007/S40256-015-0125-4  0.343
2015 Belanger AM, Keggi C, Kanias T, Gladwin MT, Kim-Shapiro DB. Effects of nitric oxide and its congeners on sickle red blood cell deformability. Transfusion. 55: 2464-72. PMID 25912054 DOI: 10.1111/Trf.13134  0.37
2015 Rotz SJ, O'Riordan MA, Kim C, de Lima M, Gladwin MT, Little JA. Traffic Light: prognosis-based eligibility for clinical trials of hematopoietic SCT in adults with sickle cell anemia. Bone Marrow Transplantation. 50: 918-23. PMID 25774596 DOI: 10.1038/Bmt.2015.11  0.635
2015 Vanderpool R, Gladwin MT. Harnessing the nitrate-nitrite-nitric oxide pathway for therapy of heart failure with preserved ejection fraction Circulation. 131: 334-336. PMID 25533965 DOI: 10.1161/Circulationaha.114.014149  0.349
2015 Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, et al. Mechanisms of human erythrocytic bioactivation of nitrite. The Journal of Biological Chemistry. 290: 1281-94. PMID 25471374 DOI: 10.1074/Jbc.M114.609222  0.356
2015 Huang S, Hou HW, Kanias T, Sertorio JT, Chen H, Sinchar D, Gladwin MT, Han J. Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage. Lab On a Chip. 15: 448-58. PMID 25406942 DOI: 10.1039/C4Lc00768A  0.33
2015 Potoka KP, Gladwin MT. Vasculopathy and pulmonary hypertension in sickle cell disease. American Journal of Physiology-Lung Cellular and Molecular Physiology. 308. PMID 25398989 DOI: 10.1152/Ajplung.00252.2014  0.442
2015 Wang J, Krizowski S, Fischer-Schrader K, Niks D, Tejero J, Sparacino-Watkins C, Wang L, Ragireddy V, Frizzell S, Kelley EE, Zhang Y, Basu P, Hille R, Schwarz G, Gladwin MT. Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide. Antioxidants & Redox Signaling. 23: 283-94. PMID 25314640 DOI: 10.1089/ars.2013.5397  0.342
2015 Al Ghouleh I, Vanderpool R, Baust J, Shiva S, Tofovic S, Hu J, Gladwin M, Pagano P. Reversal of Right Ventricular Hypertrophy and Dysfunction by Remodulin in a Rat Model of Severe Angioproliferative Pulmonary Arterial Hypertension Chest. 148: 929A. DOI: 10.1378/Chest.2262571  0.304
2015 Zhang X, Zhang W, Shah B, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Machado RF, Garcia JG, Gladwin MT, Castro OL, Gordeuk VR. Hydroxyurea Treatment Is Associated with Elevated Serum Erythropoietin Concentration but Suppressed Global Hypoxic Transcriptional Responses in Sickle Cell Disease Blood. 126: 3380-3380. DOI: 10.1182/Blood.V126.23.3380.3380  0.336
2015 Bennewitz MF, Vats R, Tutuncuoglu E, Gladwin MT, Sundd P. Platelet-Neutrophil Aggregates Promote Pulmonary Arteriole Microembolism in Sickle Cell Disease Blood. 126: 2162-2162. DOI: 10.1182/Blood.V126.23.2162.2162  0.364
2015 Vanderpool RR, Gladwin MT, Simon M. ESTIMATING THE PREVALENCE OF PULMONARY HYPERTENSION DUE TO LEFT HEART DISEASE IN PATIENTS UNDERGOING A RIGHT HEART CATHETERIZATION Journal of the American College of Cardiology. 65: A1540. DOI: 10.1016/S0735-1097(15)61540-6  0.305
2015 Vanderpool R, Gladwin M, Simon M. Hemodynamic Markers of Pulmonary Vascular Disease in Pulmonary Hypertension Due to Left Heart Disease The Journal of Heart and Lung Transplantation. 34: S118. DOI: 10.1016/J.Healun.2015.01.312  0.347
2014 Novelli EM, Hildesheim M, Rosano C, Vanderpool R, Simon M, Kato GJ, Gladwin MT. Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease. Plos One. 9: e114309. PMID 25478953 DOI: 10.1182/Blood.V124.21.2711.2711  0.342
2014 Hayes MM, Vedamurthy A, George G, Dweik R, Klings ES, Machado RF, Gladwin MT, Wilson KC, Thomson CC. Pulmonary hypertension in sickle cell disease. Annals of the American Thoracic Society. 11: 1488-9. PMID 25423000 DOI: 10.1513/Annalsats.201408-405Cme  0.369
2014 Wu F, Szczepaniak WS, Shiva S, Liu H, Wang Y, Wang L, Wang Y, Kelley EE, Chen AF, Gladwin MT, McVerry BJ. Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 307: L987-97. PMID 25326583 DOI: 10.1152/Ajplung.00063.2014  0.308
2014 Zemke AC, Shiva S, Burns JL, Moskowitz SM, Pilewski JM, Gladwin MT, Bomberger JM. Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells. Free Radical Biology & Medicine. 77: 307-16. PMID 25229185 DOI: 10.1016/J.Freeradbiomed.2014.08.011  0.308
2014 Klings ES, Machado RF, Morris CR, Gordeuk VR, Kato GJ, Ataga KI, Castro O, Hsu L, Telen MJ, Krishnamurti L, Steinberg MH, Gladwin MT. Reply: Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption. American Journal of Respiratory and Critical Care Medicine. 190: 238-40. PMID 25025360 DOI: 10.1164/Rccm.201404-0733Le  0.343
2014 Linguraru MG, Pura JA, Gladwin MT, Koroulakis AI, Minniti C, Machado RF, Kato GJ, Wood BJ. Computed tomography correlates with cardiopulmonary hemodynamics in pulmonary hypertension in adults with sickle cell disease. Pulmonary Circulation. 4: 319-29. PMID 25006451 DOI: 10.1086/675997  0.33
2014 Amsellem V, Lipskaia L, Abid S, Poupel L, Houssaini A, Quarck R, Marcos E, Mouraret N, Parpaleix A, Bobe R, Gary-Bobo G, Saker M, Dubois-Randé JL, Gladwin MT, Norris KA, et al. CCR5 as a treatment target in pulmonary arterial hypertension. Circulation. 130: 880-91. PMID 24993099 DOI: 10.1161/Circulationaha.114.010757  0.309
2014 Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, et al. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. Plos One. 9: e99489. PMID 24988120 DOI: 10.1371/Journal.Pone.0099489  0.63
2014 Lai YC, Potoka KC, Champion HC, Mora AL, Gladwin MT. Pulmonary arterial hypertension: the clinical syndrome. Circulation Research. 115: 115-30. PMID 24951762 DOI: 10.1161/Circresaha.115.301146  0.37
2014 Corti P, Gladwin MT. Is Nitrite the Circulating Endocrine Effector of Remote Ischemic Preconditioning Circulation Research. 114: 1554-1557. PMID 24812347 DOI: 10.1161/Circresaha.114.303960  0.352
2014 Klings ES, Morris CR, Hsu LL, Castro O, Gladwin MT, Mubarak KK. Pulmonary hypertension of sickle cell disease beyond classification constraints. Journal of the American College of Cardiology. 63: 2881-2. PMID 24794120 DOI: 10.1016/J.Jacc.2014.01.081  0.338
2014 Austin ED, Kawut SM, Gladwin MT, Abman SH. Pulmonary hypertension: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Annals of the American Thoracic Society. 11: S178-85. PMID 24754827 DOI: 10.1513/Annalsats.201312-443Ld  0.366
2014 Klings ES, Machado RF, Barst RJ, Morris CR, Mubarak KK, Gordeuk VR, Kato GJ, Ataga KI, Gibbs JS, Castro O, Rosenzweig EB, Sood N, Hsu L, Wilson KC, Telen MJ, ... ... Gladwin MT, et al. An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease. American Journal of Respiratory and Critical Care Medicine. 189: 727-40. PMID 24628312 DOI: 10.1164/Rccm.201401-0065St  0.363
2014 Wang D, Cortés-Puch I, Sun J, Solomon SB, Kanias T, Remy KE, Feng J, Alimchandani M, Quezado M, Helms C, Perlegas A, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia. Transfusion. 54: 1712-24. PMID 24588210 DOI: 10.1111/Trf.12607  0.332
2014 Sparacino-Watkins CE, Tejero J, Sun B, Gauthier MC, Thomas J, Ragireddy V, Merchant BA, Wang J, Azarov I, Basu P, Gladwin MT. Nitrite reductase and nitric-oxide synthase activity of the mitochondrial molybdopterin enzymes mARC1 and mARC2. The Journal of Biological Chemistry. 289: 10345-58. PMID 24500710 DOI: 10.1074/Jbc.M114.555177  0.314
2014 Liu C, Liu X, Janes J, Stapley R, Patel RP, Gladwin MT, Kim-Shapiro DB. Mechanism of faster NO scavenging by older stored red blood cells. Redox Biology. 2: 211-9. PMID 24494195 DOI: 10.1016/J.Redox.2013.12.014  0.355
2014 Tejero J, Gladwin MT. The globin superfamily: functions in nitric oxide formation and decay. Biological Chemistry. 395: 631-639. PMID 24477516 DOI: 10.1515/Hsz-2013-0289  0.33
2014 Kelley EE, Baust J, Bonacci G, Golin-Bisello F, Devlin JE, St. Croix CM, Watkins SC, Gor S, Cantu-Medellin N, Weidert ER, Frisbee JC, Gladwin MT, Champion HC, Freeman BA, Khoo NKH. Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity Cardiovascular Research. 101: 352-363. PMID 24385344 DOI: 10.1093/Cvr/Cvt341  0.336
2014 Cortés-Puch I, Wang D, Sun J, Solomon SB, Remy KE, Fernandez M, Feng J, Kanias T, Bellavia L, Sinchar D, Perlegas A, Solomon MA, Kelley WE, Popovsky MA, Gladwin MT, et al. Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood. 123: 1403-11. PMID 24366359 DOI: 10.1182/Blood-2013-11-539353  0.34
2014 Saraf SL, Molokie RE, Nouraie M, Sable CA, Luchtman-Jones L, Ensing GJ, Campbell AD, Rana SR, Niu XM, Machado RF, Gladwin MT, Gordeuk VR. Differences in the clinical and genotypic presentation of sickle cell disease around the world. Paediatric Respiratory Reviews. 15: 4-12. PMID 24361300 DOI: 10.1016/J.Prrv.2013.11.003  0.317
2014 Merx MW, Gorressen S, van de Sandt AM, Cortese-Krott MM, Ohlig J, Stern M, Rassaf T, Gödecke A, Gladwin MT, Kelm M. Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction. Basic Research in Cardiology. 109: 398. PMID 24346018 DOI: 10.1007/S00395-013-0398-1  0.329
2014 Saraf SL, Zhang X, Kanias T, Lash JP, Molokie RE, Oza B, Lai C, Rowe JH, Gowhari M, Hassan J, Desimone J, Machado RF, Gladwin MT, Little JA, Gordeuk VR. Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia. British Journal of Haematology. 164: 729-39. PMID 24329963 DOI: 10.1111/Bjh.12690  0.626
2014 Kim-Shapiro DB, Gladwin MT. Mechanisms of nitrite bioactivation. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 38: 58-68. PMID 24315961 DOI: 10.1016/J.Niox.2013.11.002  0.351
2014 Arteta M, Campbell A, Nouraie M, Rana S, Onyekwere OC, Ensing G, Sable C, Dham N, Darbari D, Luchtman-Jones L, Kato GJ, Gladwin MT, Castro OL, Minniti CP, Gordeuk VR. Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia. Journal of Pediatric Hematology/Oncology. 36: 185-9. PMID 24309610 DOI: 10.1097/Mph.0000000000000011  0.319
2014 Potoka K, Mucci C, Mutchler S, Baust J, Bueno M, Becker EM, Stasch JP, Truebel H, Straub A, Mora A, Gladwin M. Direct soluble guanylate cyclase activation improves vascular function in a mouse model of sickle cell disease F1000research. 5. DOI: 10.7490/F1000Research.1096181.1  0.326
2014 Bennewitz MF, Gladwin MT, Sundd P. In Vivo Two-Photon Excitation Microscopy Reveals Pulmonary Arteriole Micro-Embolism in Sickle Cell Disease Mice Blood. 124: 4065-4065. DOI: 10.1182/Blood.V124.21.4065.4065  0.407
2014 Saraf SL, Zhang X, Shah B, Gudehithlu KP, Kittles R, Gowhari M, Arruda J, Machado RF, Gladwin MT, Singh A, Gordeuk VR. Cell-Free Hemoglobin, HMOX1 and APOL1 in Sickle Cell Nephropathy Blood. 124: 4056-4056. DOI: 10.1182/Blood.V124.21.4056.4056  0.334
2014 Sundd P, Jimenez M, Novelli EM, Gladwin MT. Neutrophil-Platelet Micro-Emboli Enable Vaso-Occlusion in Sickle Cell Disease Blood. 124: 2695-2695. DOI: 10.1182/Blood.V124.21.2695.2695  0.362
2014 Eccleston JL, DeMino M, Kleiner DE, Reshamwala P, Zhao X, Koh C, Gladwin MT, Malech HL, Metcalfe DD, Strober W, Kato GJ, Fuss IJ, Liang J, Holland SM, Heller T. Mo1001 Nodular Regenerative Hyperplasia: Many Ways to Get There Gastroenterology. 146: S-983. DOI: 10.1016/S0016-5085(14)63570-8  0.31
2014 Wajih N, Wang J, Basu S, Liu X, Keggi C, Marvel M, Gladwin M, Kim-Shapiro D. P204 – Carbonic anhydrase contributes to red blood cell-mediated nitrite bioactivation Nitric Oxide. 42: 148-149. DOI: 10.1016/J.Niox.2014.09.145  0.318
2014 Sertorio JT, Mucci C, Straub AC, Tiernan CM, Gladwin MT. Reduced nitric oxide bioavailability contributes to endothelial dysfunction in a murine model of β-thalassemia Nitric Oxide. 42: 141. DOI: 10.1016/J.Niox.2014.09.124  0.303
2014 Potoka K, Mucci C, Mutchler S, Bueno M, Becker-Pelster E, Stasch J, Truebel H, Straub A, Mora A, Gladwin M. P172 – Direct soluble guanylate cyclase activation improves vascular function in a mouse model of sickle cell disease Nitric Oxide. 42: 138. DOI: 10.1016/J.Niox.2014.09.116  0.331
2014 Osei-Hwedieh D, Kanias T, Lee J, Gladwin M. P168 - The donor effect of sickle cell trait on host NO bioavailability following red blood cell transfusion Nitric Oxide. 42: 136-137. DOI: 10.1016/J.Niox.2014.09.112  0.327
2014 Lai Y, Tabima D, Dube J, Goncharov D, Croix CS, Garcia-Ocaña A, Goncharova E, Tofovic S, Mora A, Gladwin M. P148 - Chronic oral nitrite therapy improves hyperglycemia and normalizes pulmonary venous hypertension through a mechanism involving the activation of Sirt3 and AMPK Nitric Oxide. 42: 129-130. DOI: 10.1016/J.Niox.2014.09.092  0.329
2014 Belanger A, Keggi C, Kanias T, Gladwin M, Kim-Shapiro D. Sodium nitrosoprusside protects against oxygen cycling-induced reduction in deformability of sickle red blood cells Nitric Oxide. 42: 117. DOI: 10.1016/J.Niox.2014.09.055  0.338
2014 Belanger A, Kanias T, Gladwin M, Kim-Shapiro D. 1 - The Effects of Nitrogen Oxides and Sulfides on Gardos Channel Activity and Red Blood Cell (RBC) Deformability Free Radical Biology and Medicine. 76. DOI: 10.1016/J.Freeradbiomed.2014.10.487  0.332
2014 Gladwin M. P1 - Translating Redox Biology To Medicine: The Anion Nitrite As Anintrinsic Hypoxic Signaling Molecule And New Therapy Forpulmonary Arterial Hypertension Free Radical Biology and Medicine. 76. DOI: 10.1016/J.Freeradbiomed.2014.10.011  0.305
2013 George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Yousem SA, Toyoda Y, ... ... Gladwin MT, et al. First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease. Pulmonary Circulation. 3: 952-8. PMID 25006411 DOI: 10.1086/674749  0.33
2013 Rogers NM, Yao M, Sembrat J, George MP, Knupp H, Ross M, Sharifi-Sanjani M, Milosevic J, St Croix C, Rajkumar R, Frid MG, Hunter KS, Mazzaro L, Novelli EM, Stenmark KR, ... Gladwin MT, et al. Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension. Pulmonary Circulation. 3: 936-51. PMID 25006410 DOI: 10.1086/674754  0.357
2013 Ranayhossaini DJ, Rodriguez AI, Sahoo S, Chen BB, Mallampalli RK, Kelley EE, Csanyi G, Gladwin MT, Romero G, Pagano PJ. Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. The Journal of Biological Chemistry. 288: 36437-50. PMID 24187133 DOI: 10.1074/Jbc.M113.521344  0.35
2013 Novelli EM, Kato GJ, Hildesheim ME, Barge S, Meyer MP, Lozier J, Hassett AC, Ragni MV, Isenberg JS, Gladwin MT. Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease. Haematologica. 98: e132-4. PMID 24186313 DOI: 10.3324/Haematol.2013.092635  0.343
2013 Helms CC, Marvel M, Zhao W, Stahle M, Vest R, Kato GJ, Lee JS, Christ G, Gladwin MT, Hantgan RR, Kim-Shapiro DB. Mechanisms of hemolysis-associated platelet activation. Journal of Thrombosis and Haemostasis : Jth. 11: 2148-54. PMID 24119131 DOI: 10.1111/Jth.12422  0.325
2013 Risbano MG, Gladwin MT. Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction. Handbook of Experimental Pharmacology. 218: 315-349. PMID 24092346 DOI: 10.1007/978-3-642-38664-0_13  0.372
2013 Liu C, Zhao W, Christ GJ, Gladwin MT, Kim-Shapiro DB. Nitric oxide scavenging by red cell microparticles. Free Radical Biology & Medicine. 65: 1164-73. PMID 24051181 DOI: 10.1016/J.Freeradbiomed.2013.09.002  0.385
2013 Kato GJ, Nouraie SM, Gladwin MT. Lactate dehydrogenase and hemolysis in sickle cell disease. Blood. 122: 1091-1092. PMID 23929841 DOI: 10.1182/Blood-2013-05-505016  0.327
2013 Jain S, Gladwin MT, Novelli EM. Unraveling restrictive chronic lung disease in sickle cell disease. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease. 17: 1123-4. PMID 23928164 DOI: 10.5588/Ijtld.13.0509  0.35
2013 Klinger JR, Abman SH, Gladwin MT. Nitric oxide deficiency and endothelial dysfunction in pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine. 188: 639-46. PMID 23822809 DOI: 10.1164/Rccm.201304-0686Pp  0.377
2013 Wood KC, Cortese-Krott MM, Kovacic JC, Noguchi A, Liu VB, Wang X, Raghavachari N, Boehm M, Kato GJ, Kelm M, Gladwin MT. Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1861-71. PMID 23702660 DOI: 10.1161/Atvbaha.112.301068  0.38
2013 Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, ... ... Gladwin MT, et al. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 9451-6. PMID 23650378 DOI: 10.1073/Pnas.1219997110  0.3
2013 Zhao XJ, Wang L, Shiva S, Tejero J, Myerburg MM, Wang J, Frizzell S, Gladwin MT. Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells. Free Radical Biology & Medicine. 61: 428-37. PMID 23639566 DOI: 10.1016/J.Freeradbiomed.2013.04.031  0.35
2013 Paul R, Minniti CP, Nouraie M, Luchtman-Jones L, Campbell A, Rana S, Onyekwere O, Darbari DS, Ajayi O, Arteta M, Ensing G, Sable C, Dham N, Kato GJ, Gladwin MT, et al. Clinical correlates of acute pulmonary events in children and adolescents with sickle cell disease. European Journal of Haematology. 91: 62-8. PMID 23560516 DOI: 10.1111/Ejh.12118  0.34
2013 Wang D, Piknova B, Solomon SB, Cortes-Puch I, Kern SJ, Sun J, Kanias T, Gladwin MT, Helms C, Kim-Shapiro DB, Schechter AN, Natanson C. In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines. Transfusion. 53: 3149-63. PMID 23488474 DOI: 10.1111/Trf.12162  0.559
2013 Suzuki YJ, Steinhorn RH, Gladwin MT. Antioxidant therapy for the treatment of pulmonary hypertension. Antioxidants & Redox Signaling. 18: 1723-6. PMID 23330936 DOI: 10.1089/Ars.2013.5193  0.368
2013 Solomon SB, Wang D, Sun J, Kanias T, Feng J, Helms CC, Solomon MA, Alimchandani M, Quezado M, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood. 121: 1663-72. PMID 23255558 DOI: 10.1182/Blood-2012-10-462945  0.379
2013 George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA. Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension. American Journal of Respiratory Cell and Molecular Biology. 48: 374-81. PMID 23239493 DOI: 10.1165/Rcmb.2011-0434Oc  0.305
2013 Okamoto T, Tang X, Janocha A, Farver CF, Gladwin MT, McCurry KR. Nebulized nitrite protects rat lung grafts from ischemia reperfusion injury. The Journal of Thoracic and Cardiovascular Surgery. 145: 1108-1116. PMID 23142117 DOI: 10.1016/J.Jtcvs.2012.04.006  0.309
2013 Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, ... ... Gladwin MT, et al. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 98: 464-72. PMID 22983573 DOI: 10.3324/Haematol.2012.068965  0.644
2013 Kanias T, Wang L, Lippert A, Kim-Shapiro DB, Gladwin MT. Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis. Transfusion. 53: 981-9. PMID 22897637 DOI: 10.1111/J.1537-2995.2012.03850.X  0.379
2013 Zhang X, Kanias T, Lash JP, Molokie RE, Gowhari M, Hassan J, Gladwin MT, Gordeuk VR. Hemoglobinuria Is a Risk Factor For Kidney Disease Progression In Sickle Cell Anemia Blood. 122: 996-996. DOI: 10.1182/Blood.V122.21.996.996  0.363
2013 Lanteri M, Derek S, Busch M, Gladwin MT. Red Blood Cell Storage In Pediatric Transfer Bags Is Correlated With Increased Levels Of Hemolysis and Altered Osmotic Fragility Blood. 122: 2403-2403. DOI: 10.1182/Blood.V122.21.2403.2403  0.327
2013 Sparacino-Watkins C, Tejero J, Wang J, Ragireddy VP, Gauthier M, Thomas J, Bueno M, Azarov I, Lai Y, Sun B, Frizzell S, Basu P, Mora A, Gladwin MT. P74: Novel human mitochondrial enzyme can transform nitrite into nitric oxide Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.02.076  0.304
2013 Wang J, Krizowski S, Fischer K, Niks D, Tejero J, Wang L, Sparacino-Watkins C, Ragireddy P, Frizzell S, Kelley EE, Shiva S, Zhang Y, Basu P, Hille R, Schwarz G, ... Gladwin MT, et al. P62 Nitric Oxide. 31: S39-S40. DOI: 10.1016/J.Niox.2013.02.064  0.317
2013 Lai YC, Tabima DM, Baust JB, Dube JJ, Chacon A, Alvarez-Perez JC, Goodpaster BH, Garcia-Ocaña A, Tofovic SP, Mora AL, Gladwin MT. P47 Nitric Oxide. 31: S33-S34. DOI: 10.1016/J.Niox.2013.02.049  0.347
2013 Liu C, Liu X, Janes J, Stapley R, Patel R, Gladwin MT, Kim-Shapiro DB. Nitric Oxide and its InteractionsPSS222 - Mechanism of Faster NO Scavenging by Older Stored Red Blood Cells Free Radical Biology and Medicine. 65. DOI: 10.1016/J.Freeradbiomed.2013.10.643  0.369
2012 Gladwin MT, Kim-Shapiro DB. Vascular biology: Nitric oxide caught in traffic. Nature. 491: 344-5. PMID 23123855 DOI: 10.1038/Nature11640  0.356
2012 Solomon SB, Bellavia L, Sweeney D, Piknova B, Perlegas A, Helms CC, Ferreyra GA, Bruce King S, Raat NJ, Kern SJ, Sun J, McPhail LC, Schechter AN, Natanson C, Gladwin MT, et al. Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin. Free Radical Biology & Medicine. 53: 2229-39. PMID 23099417 DOI: 10.1016/J.Freeradbiomed.2012.10.548  0.569
2012 Sugimoto R, Okamoto T, Nakao A, Zhan J, Wang Y, Kohmoto J, Tokita D, Farver CF, Tarpey MM, Billiar TR, Gladwin MT, McCurry KR. Nitrite reduces acute lung injury and improves survival in a rat lung transplantation model American Journal of Transplantation. 12: 2938-2948. PMID 23016570 DOI: 10.1111/J.1600-6143.2012.04169.X  0.344
2012 Bae HT, Baldwin CT, Sebastiani P, Telen MJ, Ashley-Koch A, Garrett M, Hooper WC, Bean CJ, Debaun MR, Arking DE, Bhatnagar P, Casella JF, Keefer JR, Barron-Casella E, Gordeuk V, ... ... Gladwin MT, et al. Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. Blood. 120: 1961-2. PMID 22936743 DOI: 10.1182/Blood-2012-06-432849  0.33
2012 Bueno M, Wang J, Mora AL, Gladwin MT. Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics. Antioxidants & Redox Signaling. 18: 1797-809. PMID 22871207 DOI: 10.1089/Ars.2012.4833  0.339
2012 Kanias T, Gladwin MT. Nitric oxide, hemolysis, and the red blood cell storage lesion: interactions between transfusion, donor, and recipient. Transfusion. 52: 1388-1392. PMID 22780890 DOI: 10.1111/J.1537-2995.2012.03748.X  0.38
2012 Totzeck M, Hendgen-Cotta UB, Luedike P, Berenbrink M, Klare JP, Steinhoff HJ, Semmler D, Shiva S, Williams D, Kipar A, Gladwin MT, Schrader J, Kelm M, Cossins AR, Rassaf T. Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation. Circulation. 126: 325-34. PMID 22685116 DOI: 10.1161/Circulationaha.111.087155  0.37
2012 Sparacino-Watkins CE, Lai YC, Gladwin MT. Nitrate-nitrite-nitric oxide pathway in pulmonary arterial hypertension therapeutics. Circulation. 125: 2824-6. PMID 22572912 DOI: 10.1161/Circulationaha.112.107821  0.394
2012 Tejero J, Basu S, Helms C, Hogg N, King SB, Kim-Shapiro DB, Gladwin MT. Low NO concentration dependence of reductive nitrosylation reaction of hemoglobin. The Journal of Biological Chemistry. 287: 18262-74. PMID 22493289 DOI: 10.1074/Jbc.M111.298927  0.302
2012 Chandra D, Stamm JA, Palevsky PM, Leader JK, Fuhrman CR, Zhang Y, Bon J, Duncan SR, Branch RA, Weissfeld J, Gur D, Gladwin MT, Sciurba FC. The relationship between pulmonary emphysema and kidney function in smokers. Chest. 142: 655-62. PMID 22459775 DOI: 10.1378/Chest.11-1456  0.301
2012 Mehari A, Gladwin MT, Tian X, Machado RF, Kato GJ. Mortality in Adults With Sickle Cell Disease and Pulmonary Hypertension Jama. 307: 1254-1256. PMID 22453563 DOI: 10.1001/Jama.2012.358  0.347
2012 Miller AC, Gladwin MT. Pulmonary complications of sickle cell disease. American Journal of Respiratory and Critical Care Medicine. 185: 1154-65. PMID 22447965 DOI: 10.1164/Rccm.201111-2082Ci  0.362
2012 Gladwin MT, Kanias T, Kim-Shapiro DB. Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease. The Journal of Clinical Investigation. 122: 1205-8. PMID 22446184 DOI: 10.1172/Jci62972  0.384
2012 Gladwin MT, Sachdev V. Cardiovascular abnormalities in sickle cell disease Journal of the American College of Cardiology. 59: 1123-1133. PMID 22440212 DOI: 10.1016/J.Jacc.2011.10.900  0.395
2012 Wang L, Frizzell SA, Zhao X, Gladwin MT. Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 26: 203-10. PMID 22425780 DOI: 10.1016/J.Niox.2012.03.002  0.351
2012 Novelli EM, Huynh C, Gladwin MT, Moore CG, Ragni MV. Pulmonary embolism in sickle cell disease: a case-control study. Journal of Thrombosis and Haemostasis : Jth. 10: 760-6. PMID 22417249 DOI: 10.1111/J.1538-7836.2012.04697.X  0.324
2012 Tabima DM, Frizzell S, Gladwin MT. Reactive oxygen and nitrogen species in pulmonary hypertension. Free Radical Biology and Medicine. 52: 1970-1986. PMID 22401856 DOI: 10.1016/J.Freeradbiomed.2012.02.041  0.416
2012 Novelli EM, Kato GJ, Ragni MV, Zhang Y, Hildesheim ME, Nouraie M, Barge S, Meyer MP, Hassett AC, Gordeuk VR, Gladwin MT, Isenberg JS. Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates. American Journal of Hematology. 87: 326-30. PMID 22318901 DOI: 10.1002/Ajh.22274  0.352
2012 Morris A, Gingo MR, George MP, Lucht L, Kessinger C, Singh V, Hillenbrand M, Busch M, McMahon D, Norris KA, Champion HC, Gladwin MT, Zhang Y, Steele C, Sciurba FC. Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era. Aids (London, England). 26: 731-40. PMID 22210636 DOI: 10.1097/Qad.0B013E32835099Ae  0.331
2012 Sable CA, Aliyu ZY, Dham N, Nouraie M, Sachdev V, Sidenko S, Miasnikova GY, Polyakova LA, Sergueeva AI, Okhotin DJ, Bushuev V, Remaley AT, Niu X, Castro OL, Gladwin MT, et al. Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHL(R200W) mutation (Chuvash polycythemia). Haematologica. 97: 193-200. PMID 21993671 DOI: 10.3324/Haematol.2011.051839  0.324
2012 Ayyappan S, Drawz P, Nouraie M, Hildesheim ME, Zhang Y, Gordeuk VR, Hostetter TH, Gladwin MT, Little JA. Renal Disease in Sickle Cell: Clinically Varied and Associated with Increased Mortality Blood. 120: 90-90. DOI: 10.1182/Blood.V120.21.90.90  0.62
2012 Gladwin MT, Barst RJ, Gibbs JSR, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Zhang Y, Morris CR, Rosenzweig EB, et al. Risk Factors for Death in 632 Patients with Sickle Cell Anemia in the United States and United Kingdom Blood. 120: 3240-3240. DOI: 10.1182/Blood.V120.21.3240.3240  0.351
2011 Gladwin MT, Tejero J. Nitrite-NO bailout for a NOS complex too big to fail. Nature Medicine. 17: 1556-1557. PMID 22146458 DOI: 10.1038/Nm.2591  0.319
2011 Gladwin MT. Prevalence, risk factors and mortality of pulmonary hypertension defined by right heart catheterization in patients with sickle cell disease Expert Review of Hematology. 4: 593-596. PMID 22077523 DOI: 10.1586/Ehm.11.66  0.388
2011 Stamm JA, McVerry BJ, Mathier MA, Donahoe MP, Saul MI, Gladwin MT. Doppler-defined pulmonary hypertension in medical intensive care unit patients: Retrospective investigation of risk factors and impact on mortality. Pulmonary Circulation. 1: 95-102. PMID 22034595 DOI: 10.4103/2045-8932.78104  0.317
2011 Jayaraman T, Tejero J, Chen BB, Blood AB, Frizzell S, Shapiro C, Tiso M, Hood BL, Wang X, Zhao X, Conrads TP, Mallampalli RK, Gladwin MT. 14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide. The Journal of Biological Chemistry. 286: 42679-89. PMID 21965683 DOI: 10.1074/Jbc.M111.271973  0.3
2011 Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, ... ... Gladwin MT, et al. Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation. 124: 1452-60. PMID 21900080 DOI: 10.1161/Circulationaha.111.032920  0.608
2011 Azarov I, Liu C, Reynolds H, Tsekouras Z, Lee JS, Gladwin MT, Kim-Shapiro DB. Mechanisms of slower nitric oxide uptake by red blood cells and other hemoglobin-containing vesicles. The Journal of Biological Chemistry. 286: 33567-79. PMID 21808057 DOI: 10.1074/Jbc.M111.228650  0.304
2011 Chandra D, Sciurba FC, Gladwin MT. Endothelial chronic destructive pulmonary disease (E-CDPD): is endothelial apoptosis a subphenotype or prequel to COPD? American Journal of Respiratory and Critical Care Medicine. 184: 153-5. PMID 21765029 DOI: 10.1164/Rccm.201104-0758Ed  0.309
2011 Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, ... ... Gladwin MT, et al. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation. 124: 465-76. PMID 21747051 DOI: 10.1161/Circulationaha.110.008698  0.372
2011 Al Ghouleh I, Khoo NKH, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, et al. Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling Free Radical Biology and Medicine. 51: 1271-1288. PMID 21722728 DOI: 10.1016/J.Freeradbiomed.2011.06.011  0.326
2011 Machado RF, Hildesheim M, Mendelsohn L, Remaley AT, Kato GJ, Gladwin MT. NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease. British Journal of Haematology. 154: 512-20. PMID 21689089 DOI: 10.1111/J.1365-2141.2011.08777.X  0.361
2011 Hanson MS, Piknova B, Keszler A, Diers AR, Wang X, Gladwin MT, Hillery CA, Hogg N. Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. British Journal of Haematology. 154: 502-11. PMID 21595649 DOI: 10.1111/J.1365-2141.2011.08738.X  0.366
2011 Nouraie M, Cheng K, Niu X, Moore-King E, Fadojutimi-Akinsi MF, Minniti CP, Sable C, Rana S, Dham N, Campbell A, Ensing G, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR. Predictors of osteoclast activity in patients with sickle cell disease. Haematologica. 96: 1092-8. PMID 21546502 DOI: 10.3324/Haematol.2011.042499  0.336
2011 Machado RF, Barst RJ, Yovetich NA, Hassell KL, Kato GJ, Gordeuk VR, Gibbs JS, Little JA, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, ... ... Gladwin MT, et al. Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood. 118: 855-64. PMID 21527519 DOI: 10.1182/Blood-2010-09-306167  0.611
2011 Kim-Shapiro DB, Lee J, Gladwin MT. Storage lesion: role of red blood cell breakdown. Transfusion. 51: 844-51. PMID 21496045 DOI: 10.1111/J.1537-2995.2011.03100.X  0.353
2011 Alef MJ, Vallabhaneni R, Carchman E, Morris SM, Shiva S, Wang Y, Kelley EE, Tarpey MM, Gladwin MT, Tzeng E, Zuckerbraun BS. Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats. The Journal of Clinical Investigation. 121: 1646-56. PMID 21436585 DOI: 10.1172/Jci44079  0.312
2011 Gladwin MT, Kato GJ, Weiner D, Onyekwere OC, Dampier C, Hsu L, Hagar RW, Howard T, Nuss R, Okam MM, Tremonti CK, Berman B, Villella A, Krishnamurti L, Lanzkron S, et al. Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial. Jama. 305: 893-902. PMID 21364138 DOI: 10.1001/Jama.2011.235  0.324
2011 Tiso M, Tejero J, Basu S, Azarov I, Wang X, Simplaceanu V, Frizzell S, Jayaraman T, Geary L, Shapiro C, Ho C, Shiva S, Kim-Shapiro DB, Gladwin MT. Human neuroglobin functions as a redox-regulated nitrite reductase. The Journal of Biological Chemistry. 286: 18277-89. PMID 21296891 DOI: 10.1074/Jbc.M110.159541  0.308
2011 Gladwin MT. Adenosine receptor crossroads in sickle cell disease Nature Medicine. 17: 38-40. PMID 21217677 DOI: 10.1038/Nm0111-38  0.35
2011 Zuckerbraun BS, George P, Gladwin MT. Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling Cardiovascular Research. 89: 542-552. PMID 21177703 DOI: 10.1093/Cvr/Cvq370  0.404
2011 Shiva S, Rassaf T, Patel RP, Gladwin MT. The detection of the nitrite reductase and NO-generating properties of haemoglobin by mitochondrial inhibition Cardiovascular Research. 89: 566-573. PMID 20952414 DOI: 10.1093/Cvr/Cvq327  0.337
2011 Cuttica MJ, Langenickel T, Noguchi A, Machado RF, Gladwin MT, Boehm M. Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage. American Journal of Respiratory Cell and Molecular Biology. 45: 62-71. PMID 20813993 DOI: 10.1165/Rcmb.2009-0365Oc  0.346
2011 Novelli EM, Yao M, Huang X, Baust J, Champion H, Gladwin MT, Isenberg J. TSP1-CD47 Signaling Modulates the Severity of Pulmonary Hypertension in a Mouse Model of Sickle Cell Disease Blood. 118: 898-898. DOI: 10.1182/Blood.V118.21.898.898  0.34
2011 Carlisle CR, Stahle M, Vest R, Hantgan R, Lee J, Gladwin MT, Kim-Shapiro D. Mechanistic Study of Hemoglobin Induced Platelet Activation Blood. 118: 5262-5262. DOI: 10.1182/Blood.V118.21.5262.5262  0.305
2011 Nouraie M, Rana SR, Castro OL, Luchtman-Jones L, Sable C, Dham N, Minniti C, Kato GJ, Gladwin MT, Ensing G, Arteta M, Campbell A, Gordeuk VR. Predictors of Mortality in Children and Adolescents with Sickle Cell Disease: The PUSH Study Blood. 118: 515-515. DOI: 10.1182/Blood.V118.21.515.515  0.306
2011 Kanias T, Lee J, Yazer MH, Triulzi DJ, Lippert A, Gladwin MT. Correlation Between Female Gender and the Red Blood Cell Propensity to Hemolyze Under Various Stresses Blood. 118: 2325-2325. DOI: 10.1182/Blood.V118.21.2325.2325  0.305
2011 Milton JN, Sebastiani P, Zhang Y, Nouraie M, Lee J, Baldwin CT, Zhao X, Xiong Z, Zeng Q, Kato GJ, Goldsmith JC, Taylor JG, Onyekwere O, Gordeuk VR, Machado RF, ... ... Gladwin MT, et al. Clinical and Genetic Variability of Red Blood Cell Hemolysis in Sickle Cell Anemia Blood. 118: 1077-1077. DOI: 10.1182/Blood.V118.21.1077.1077  0.406
2011 Goel R, Hassell KL, Machado RF, Barst RJ, Yovetich N, Kato GJ, Gordeuk VR, Little JA, Gibbs JSR, Schraufnagel DE, Girgis RE, Rosenzweig EB, Morris CR, Badesch DB, Lanzkron S, ... ... Gladwin MT, et al. Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study Blood. 118: 1074-1074. DOI: 10.1182/Blood.V118.21.1074.1074  0.612
2011 Wang J, Fischer K, Krizowski S, Tejero J, Zhao X, Wang L, Frizzell S, Schwarz G, Gladwin M. P41. Sulfite oxidase: A novel nitrite reductase that generates nitric oxide Nitric Oxide. 24. DOI: 10.1016/J.Niox.2011.03.272  0.312
2011 Wang L, Gladwin M. P28. Sodium nitrite enhances pulmonary epithelial cells wound healing under normoxia via cyclic GMP-independent signaling pathways Nitric Oxide. 24. DOI: 10.1016/J.Niox.2011.03.259  0.316
2011 Wang J, Krizowski S, Fischer K, Tejero J, Zhao X, Wang L, Frizzell S, Kelley E, Schwarz G, Gladwin MT. Sulfite Oxidase: A Novel Nitrite Reductase that Generates Nitric Oxide Free Radical Biology and Medicine. 51: S164. DOI: 10.1016/J.Freeradbiomed.2011.10.233  0.308
2011 Kanias T, Wang L, Lippert A, Gladwin MT. Red blood Cell eNOS Does Not Modulate Hemolytic Response To Various Stressors Or Prolonged Hypothermic Storage Free Radical Biology and Medicine. 51. DOI: 10.1016/J.Freeradbiomed.2011.10.216  0.314
2011 Azarov I, Liu C, Reynolds H, Tsekouras Z, Lee J, Gladwin M, Kim-Shapiro D. Measurement and Simulation of Nitric Oxide Uptake by Hemoglobin-Containing Vesicles and Red Blood Cells Free Radical Biology and Medicine. 51. DOI: 10.1016/J.Freeradbiomed.2011.10.204  0.349
2010 Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, ... ... Gladwin MT, et al. Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. American Journal of Respiratory and Critical Care Medicine. 182: 1554-62. PMID 20833821 DOI: 10.1164/Rccm.201006-0869Ws  0.328
2010 Jain S, Gladwin MT. Arginine metabolism and nitric oxide bioavailability in sickle cell disease. Journal of Pediatric Hematology/Oncology. 32: e247-8. PMID 20724948 DOI: 10.1097/Mph.0B013E3181Ec0B00  0.354
2010 Gladwin MT, Barst RJ, Castro OL, Gordeuk VR, Hillery CA, Kato GJ, Kim-Shapiro DB, Machado R, Morris CR, Steinberg MH, Vichinsky EP. Pulmonary hypertension and NO in sickle cell. Blood. 116: 852-4. PMID 20688967 DOI: 10.1182/Blood-2010-04-282095  0.314
2010 Janka JJ, Koita OA, Traoré B, Traoré JM, Mzayek F, Sachdev V, Wang X, Sanogo K, Sangaré L, Mendelsohn L, Masur H, Kato GJ, Gladwin MT, Krogstad DJ. Increased pulmonary pressures and myocardial wall stress in children with severe malaria. The Journal of Infectious Diseases. 202: 791-800. PMID 20662718 DOI: 10.1086/655225  0.374
2010 Hon YY, Sun H, Dejam A, Gladwin MT. Characterization Of Erythrocytic Uptake And Release And Disposition Pathways Of Nitrite, Nitrate, Methemoglobin, And Iron-Nitrosyl Hemoglobin In The Human Circulation Drug Metabolism and Disposition. 38: 1707-1713. PMID 20634335 DOI: 10.1124/Dmd.110.034355  0.317
2010 Cuttica MJ, Kalhan R, Shlobin OA, Ahmad S, Gladwin M, Machado RF, Barnett SD, Nathan SD. Categorization and impact of pulmonary hypertension in patients with advanced COPD. Respiratory Medicine. 104: 1877-1882. PMID 20547449 DOI: 10.1016/J.Rmed.2010.05.009  0.348
2010 Machado RF, Gladwin MT. Pulmonary Hypertension in Hemolytic Disorders: Pulmonary Vascular Disease: The Global Perspective Chest. 137. PMID 20522578 DOI: 10.1378/Chest.09-3057  0.367
2010 Gladwin MT, Ghofrani HA. Update on pulmonary hypertension 2009 American Journal of Respiratory and Critical Care Medicine. 181: 1020-1026. PMID 20460546 DOI: 10.1164/Rccm.201002-0235Up  0.315
2010 Linguraru MG, Pura JA, Van Uitert RL, Mukherjee N, Summers RM, Minniti C, Gladwin MT, Kato G, Machado RF, Wood BJ. Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension. Medical Physics. 37: 1522-32. PMID 20443473 DOI: 10.1118/1.3355892  0.31
2010 Aliyu ZY, Suleiman A, Attah E, Mamman AI, Babadoko A, Nouraie M, Mendelsohn L, Kato GJ, Gordeuk VR, Gladwin MT. NT-proBNP as a marker of cardiopulmonary status in sickle cell anaemia in Africa. British Journal of Haematology. 150: 102-7. PMID 20408845 DOI: 10.1111/J.1365-2141.2010.08195.X  0.369
2010 Lee JS, Gladwin MT. Bad blood: the risks of red cell storage. Nature Medicine. 16: 381-2. PMID 20376046 DOI: 10.1038/Nm0410-381  0.309
2010 Hill A, Rother RP, Wang X, Morris SM, Quinn-Senger K, Kelly R, Richards SJ, Bessler M, Bell L, Hillmen P, Gladwin MT. Effect of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria. British Journal of Haematology. 149: 414-25. PMID 20230403 DOI: 10.1111/J.1365-2141.2010.08096.X  0.379
2010 Barst RJ, Mubarak KK, Machado RF, Ataga KI, Benza RL, Castro O, Naeije R, Sood N, Swerdlow PS, Hildesheim M, Gladwin MT. Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies. British Journal of Haematology. 149: 426-35. PMID 20175775 DOI: 10.1111/J.1365-2141.2010.08097.X  0.377
2010 Donadee CL, Gladwin MT. Hemodialysis Hyperhemolysis: A Novel Mechanism of Endothelial Dysfunction and Cardiovascular Risk? Journal of the American College of Cardiology. 55: 460-462. PMID 20117460 DOI: 10.1016/J.Jacc.2009.08.061  0.35
2010 Presley TD, Perlegas AS, Bain LE, Ballas SK, Nichols JS, Sabio H, Gladwin MT, Kato GJ, Kim-Shapiro DB. Effects of a single sickling event on the mechanical fragility of sickle cell trait erythrocytes. Hemoglobin. 34: 24-36. PMID 20113285 DOI: 10.3109/03630260903546999  0.361
2010 Zuckerbraun BS, Shiva S, Ifedigbo E, Mathier MA, Mollen KP, Rao J, Bauer PM, Choi JJ, Curtis E, Choi AM, Gladwin MT. Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation. Circulation. 121: 98-109. PMID 20026772 DOI: 10.1161/Circulationaha.109.891077  0.376
2010 Cho C, Kato GJ, Yang SH, Bae SW, Lee JS, Gladwin MT, Rhee SG. Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia Antioxidants & Redox Signaling. 13: 1-11. PMID 19951064 DOI: 10.1089/Ars.2009.2978  0.371
2010 Kato GJ, Sable C, Ensing G, Dham N, Minniti C, Remaley A, Campbell A, Arteta M, Rana S, Darbari D, Nouraie M, Onyekwere O, Gladwin M, Castro O, Gordeuk VR. Plasma Level of NT-Pro-BNP In Children with Sickle Cell Disease Is Associated with Degree of Anemia and Left Ventricular Measures: The PUSH Study Blood. 116: 948-948. DOI: 10.1182/Blood.V116.21.948.948  0.346
2010 Barst RJ, Kato GJ, Sachdev V, Nouraie M, Machado RF, Hassell K, Gibbs S, Little J, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Castro O, ... ... Gladwin M, et al. Predictors of Six-Minute Walk Distance In Adults with Sickle Cell Anemia In the Walk-PHaSST Study Blood. 116: 947-947. DOI: 10.1182/Blood.V116.21.947.947  0.636
2010 Novelli EM, Kato GJ, Ragni MV, Hildesheim ME, Barge S, Meyer MP, Hassett AC, Gladwin M, Isenberg J. Plasma Thrombospondin 1 Is Increased and Associated with Markers of Vasculopathy In Sickle Cell Disease Blood. 116: 946-946. DOI: 10.1182/Blood.V116.21.946.946  0.378
2010 Goel R, Hassell K, Castro O, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Gibbs S, Little JA, Schraufnagel DE, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Goldsmith JC, ... ... Gladwin M, et al. Cigarette Smoking Is An Independent Predictor of Chronic Pain In Sickle Cell Patients: Results From the Walk-PHaSST Study Blood. 116: 4804-4804. DOI: 10.1182/Blood.V116.21.4804.4804  0.577
2010 Mehari A, Tian X, Alam S, Xu D, Seamon C, Gladwin MT, Machado RF, Kato GJ. Hemodynamic Parameters Predict Mortality In Sickle Cell Disease-Related Pulmonary Hypertension Blood. 116: 2668-2668. DOI: 10.1182/Blood.V116.21.2668.2668  0.35
2010 Krishnamurti L, Goel R, Castro O, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Gibbs S, Little JA, Schraufnagel DE, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Goldsmith JC, ... ... Gladwin M, et al. Chronic Pain Is An Independent Predictor of Lower 6 Minute Walk Distance In Patients with Sickle Cell Disease: Results From Walk-PHaSST Study Blood. 116: 2658-2658. DOI: 10.1182/Blood.V116.21.2658.2658  0.577
2010 Nouraie M, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Hassell K, Gibbs JSR, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Badesch DB, Lanzkron S, ... ... Gladwin M, et al. NT-Probnp as a Marker of Cardiopulmonary Compromise and Exercise Limitation In Adults with Sickle Cell Anemia In the Walk-PHaSST Study Blood. 116: 1639-1639. DOI: 10.1182/Blood.V116.21.1639.1639  0.636
2010 Wang J, Fischer K, Zhao X, Tejero J, Kelley EE, Wang L, Shiva S, Frizzell S, Zhang Y, Basu P, Schwarz G, Gladwin MT. Novel Function of Sulfite Oxidase as a Nitrite Reductase that Generates Nitric Oxide Free Radical Biology and Medicine. 49: S122. DOI: 10.1016/J.Freeradbiomed.2010.10.335  0.307
2010 Tejero J, Basu S, Carlisle C, Hogg N, King SB, Kim-Shapiro DB, Gladwin MT. The Reductive Nitrosylation of Hemoglobin: Low Nitric Oxide Effects and Mechanisms for N2O3 Formation Free Radical Biology and Medicine. 49: S121. DOI: 10.1016/J.Freeradbiomed.2010.10.332  0.326
2010 Azarov I, Liu C, Reynolds H, Lee J, Donadee C, Raat H, Gladwin M, Kim-Shapiro D. Kinetics of Nitric Oxide reactivity with Micro Vesicle-Encapsulated Hemoglobin Free Radical Biology and Medicine. 49: S108. DOI: 10.1016/J.Freeradbiomed.2010.10.285  0.309
2010 Wang L, Gladwin MT. Sodium Nitrite Enhances Pulmonary Epithelial Cells Wound Healing Under Normoxia via Cyclic GMPindependent Signaling Pathways Free Radical Biology and Medicine. 49. DOI: 10.1016/J.Freeradbiomed.2010.10.276  0.305
2009 Niu X, Nouraie M, Campbell A, Rana S, Minniti CP, Sable C, Darbari D, Dham N, Reading NS, Prchal JT, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR. Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease. Plos One. 4: e7956. PMID 19956689 DOI: 10.1371/Journal.Pone.0007956  0.369
2009 Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, et al. Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology. 5: 865-9. PMID 19915529 DOI: 10.1038/Nchembio.260  0.545
2009 Minniti CP, Machado RF, Coles WA, Sachdev V, Gladwin MT, Kato GJ. Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease. British Journal of Haematology. 147: 737-43. PMID 19775299 DOI: 10.1111/J.1365-2141.2009.07906.X  0.361
2009 Gordeuk VR, Campbell A, Rana S, Nouraie M, Niu X, Minniti CP, Sable C, Darbari D, Dham N, Onyekwere O, Ammosova T, Nekhai S, Kato GJ, Gladwin MT, Castro OL. Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. Blood. 114: 4639-44. PMID 19724057 DOI: 10.1182/Blood-2009-04-218040  0.364
2009 Gladwin MT, Kim-Shapiro DB. Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis. Current Opinion in Hematology. 16: 515-23. PMID 19701085 DOI: 10.1097/Moh.0B013E32833157F4  0.341
2009 Dham N, Ensing G, Minniti C, Campbell A, Arteta M, Rana S, Darbari D, Nouraie M, Onyekwere O, Lasota M, Kato GJ, Gladwin MT, Castro O, Gordeuk V, Sable C. Prospective Echocardiography Assessment of Pulmonary Hypertension and Its Potential Etiologies in Children With Sickle Cell Disease American Journal of Cardiology. 104: 713-720. PMID 19699350 DOI: 10.1016/J.Amjcard.2009.04.034  0.35
2009 Raghavachari N, Xu X, Munson PJ, Gladwin MT. Characterization of whole blood gene expression profiles as a sequel to globin mRNA reduction in patients with sickle cell disease. Plos One. 4: e6484. PMID 19649296 DOI: 10.1371/Journal.Pone.0006484  0.334
2009 Kato GJ, Hebbel RP, Steinberg MH, Gladwin MT. Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions. American Journal of Hematology. 84: 618-25. PMID 19610078 DOI: 10.1002/Ajh.21475  0.422
2009 Bivalacqua TJ, Musicki B, Hsu LL, Gladwin MT, Burnett AL, Champion HC. Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism. The Journal of Sexual Medicine. 6: 2494-504. PMID 19523035 DOI: 10.1111/J.1743-6109.2009.01359.X  0.314
2009 Isenberg JS, Shiva S, Gladwin M. Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation Nitric Oxide - Biology and Chemistry. 21: 52-62. PMID 19481167 DOI: 10.1016/J.Niox.2009.05.005  0.304
2009 Pellegrino D, Shiva S, Angelone T, Gladwin MT, Tota B. Nitrite exerts potent negative inotropy in the isolated heart via eNOS-independent nitric oxide generation and cGMP-PKG pathway activation Biochimica Et Biophysica Acta - Bioenergetics. 1787: 818-827. PMID 19248761 DOI: 10.1016/J.Bbabio.2009.02.007  0.314
2009 van Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, Kozlov AV, Li H, Lundberg JO, Mason R, Nohl H, Rassaf T, Samouilov A, Slama-Schwok A, Shiva S, ... ... Gladwin MT, et al. Nitrite as regulator of hypoxic signaling in mammalian physiology. Medicinal Research Reviews. 29: 683-741. PMID 19219851 DOI: 10.1002/Med.20151  0.345
2009 Little JA, Hauser KP, Martyr SE, Harris A, Maric I, Morris CR, Suh JH, Taylor J, Castro O, Machado R, Kato G, Gladwin MT. Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy. European Journal of Haematology. 82: 315-21. PMID 19215288 DOI: 10.1111/J.1600-0609.2009.01210.X  0.615
2009 Minniti CP, Sable C, Campbell A, Rana S, Ensing G, Dham N, Onyekwere O, Nouraie M, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR. Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation Haematologica. 94: 340-347. PMID 19211639 DOI: 10.3324/Haematol.13812  0.345
2009 Blood AB, Tiso M, Verma ST, Lo J, Joshi MS, Azarov I, Longo LD, Gladwin MT, Kim-Shapiro DB, Power GG. Increased nitrite reductase activity of fetal versus adult ovine hemoglobin. American Journal of Physiology. Heart and Circulatory Physiology. 296: H237-46. PMID 19028797 DOI: 10.1152/Ajpheart.00601.2008  0.339
2009 Gladwin MT, Grubina R, Doyle MP. The new chemical biology of nitrite reactions with hemoglobin: R-state catalysis, oxidative denitrosylation, and nitrite reductase/anhydrase. Accounts of Chemical Research. 42: 157-67. PMID 18783254 DOI: 10.1021/Ar800089J  0.314
2009 Nouraie M, Reading NS, Campbell A, Minniti C, Rana SR, Luchtman-Jones L, Sable C, Dham N, Ensing G, Kato GJ, Gladwin M, Castro OL, Prchal JT, Gordeuk VR. Cytochrome b5 Reductase T116S Mutation and Hemolysis in Sickle Cell Disease. Blood. 114: 903-903. DOI: 10.1182/Blood.V114.22.903.903  0.316
2009 Gordeuk VR, Luchtman-Jones L, Campbell AD, Rana SR, Nouraie M, Sable C, Dham N, Ensing G, Minniti C, Kato GJ, Gladwin M, Castro OL. Hemolysis-Associated Elevation in Tricuspid Regurgitation Velocity Predicts Reduction in Six-Minute Walk Distance After Two Years of Follow up in Children and Adolescents with Sickle Cell Disease. Blood. 114: 574-574. DOI: 10.1182/Blood.V114.22.574.574  0.354
2009 Machado RF, Barst RJ, Yovetich NA, Hassell KL, Goldsmith JC, Woolson R, Gordeuk VR, Gibbs S, Little JA, Kato GJ, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Berman-Rosenzweig E, ... ... Gladwin M, et al. Safety and Efficacy of Sildenafil Therapy for Doppler-Defined Pulmonary Hypertension in Patients with Sickle Cell Disease: Preliminary Results of the Walk-PHaSST Clinical Trial. Blood. 114: 571-571. DOI: 10.1182/Blood.V114.22.571.571  0.616
2009 Westerman MP, Pizzey A, Meiselman HJ, Mohandas N, Kato GJ, Gladwin M, Mendelsohn L, Dumanski J, Porter JB. Phenotypic and Genetic Discordance in Monozygotic Twins with Sickle Anemia and ð-Thalassemia. Blood. 114: 5084-5084. DOI: 10.1182/Blood.V114.22.5084.5084  0.304
2009 Klings ES, Dworkis DA, Sedgewick A, Hartley SW, Allison A, Telen MJ, Kato GJ, Gladwin M, Sebastiani P, Baldwin CT, Steinberg MH. Genetic Polymorphisms in NEDD4L Are Associated with Pulmonary Hypertension of Sickle Cell Anemia. Blood. 114: 2562-2562. DOI: 10.1182/Blood.V114.22.2562.2562  0.352
2009 Machado RF, Hildescheim M, Mendelsohn L, Kato GJ, Gladwin MT. NT-Pro Brain Natriuretic Peptide Levels and the Risk of Stroke and Death in the Cooperative Study of Sickle Cell Disease. Blood. 114: 1541-1541. DOI: 10.1182/Blood.V114.22.1541.1541  0.329
2009 Nouraie M, Reading NS, Campbell A, Minniti C, Rana SR, Luchtman-Jones L, Gladwin M, Kato GJ, Castro OL, Prchal JT, Gordeuk VR. Association of G6PD −202/−376 with Lower Hemoglobin Concentration but Not Increased Hemolysis in Patients with Sickle Cell Anemia. Blood. 114: 1511-1511. DOI: 10.1182/Blood.V114.22.1511.1511  0.353
2009 Goetz BI, Wang P, Shields HW, Basu S, Grubina R, Huang J, Conradie J, Huang Z, Jeffers A, Jiang A, He X, Azarov I, Seibert R, Mehta A, Patel R, ... ... Gladwin MT, et al. Reply to 'Nitrite-methemoglobin inadequate for hypoxic vasodilation' Nature Chemical Biology. 5: 367. DOI: 10.1038/Nchembio0609-367  0.321
2008 Gladwin MT. Current and future therapies of sickle cell anemia: an historical perspective. Hematology. 2008: 176-176. PMID 19074077 DOI: 10.1182/Asheducation-2008.1.176  0.319
2008 Kato GJ, Gladwin MT. Evolution of Novel Small-Molecule Therapeutics Targeting Sickle Cell Vasculopathy Jama. 300: 2638-2646. PMID 19066384 DOI: 10.1001/Jama.2008.598  0.423
2008 Gladwin MT, Vichinsky E. Pulmonary complications of sickle cell disease. The New England Journal of Medicine. 359: 2254-2265. PMID 19020327 DOI: 10.1056/Nejmra0804411  0.352
2008 Morris CR, Gladwin MT, Kato GJ. Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders. Current Molecular Medicine. 8: 620-32. PMID 18991648 DOI: 10.2174/156652408786241447  0.415
2008 Basu S, Azarova NA, Font MD, King SB, Hogg N, Gladwin MT, Shiva S, Kim-Shapiro DB. Nitrite reductase activity of cytochrome c. The Journal of Biological Chemistry. 283: 32590-7. PMID 18820338 DOI: 10.1074/Jbc.M806934200  0.307
2008 Sinha SS, Shiva S, Gladwin MT. Myocardial protection by nitrite: evidence that this reperfusion therapeutic will not be lost in translation. Trends in Cardiovascular Medicine. 18: 163-72. PMID 18790386 DOI: 10.1016/J.Tcm.2008.05.001  0.31
2008 Mack AK, McGowan Ii VR, Tremonti CK, Ackah D, Barnett C, Machado RF, Gladwin MT, Kato GJ. Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study. British Journal of Haematology. 142: 971-8. PMID 18671702 DOI: 10.1111/J.1365-2141.2008.07259.X  0.311
2008 Hendgen-Cotta UB, Merx MW, Shiva S, Schmitz J, Becher S, Klare JP, Steinhoff HJ, Goedecke A, Schrader J, Gladwin MT, Kelm M, Rassaf T. Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. 105: 10256-61. PMID 18632562 DOI: 10.1073/Pnas.0801336105  0.313
2008 Gladwin MT, Kim-Shapiro DB. The functional nitrite reductase activity of the heme-globins. Blood. 112: 2636-47. PMID 18596228 DOI: 10.1182/Blood-2008-01-115261  0.328
2008 Minneci PC, Deans KJ, Shiva S, Zhi H, Banks SM, Kern S, Natanson C, Solomon SB, Gladwin MT. Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis. American Journal of Physiology. Heart and Circulatory Physiology. 295: H743-54. PMID 18552166 DOI: 10.1152/Ajpheart.00151.2008  0.391
2008 Nathan SD, Shlobin OA, Ahmad S, Barnett SD, Burton NA, Gladwin MT, Machado RF. Pulmonary hypertension in patients with bronchiolitis obliterans syndrome listed for retransplantation. American Journal of Transplantation. 8: 1506-1511. PMID 18510629 DOI: 10.1111/J.1600-6143.2008.02277.X  0.332
2008 Krajewski ML, Hsu LL, Gladwin MT. The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology. American Journal of Physiology. Heart and Circulatory Physiology. 295: H4-7. PMID 18502905 DOI: 10.1152/Ajpheart.00499.2008  0.407
2008 Taylor JG, Nolan VG, Mendelsohn L, Kato GJ, Gladwin MT, Steinberg MH. Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain. Plos One. 3: e2095. PMID 18461136 DOI: 10.1371/Journal.Pone.0002095  0.377
2008 Aliyu ZY, Gordeuk V, Sachdev V, Babadoko A, Mamman AI, Akpanpe P, Attah E, Suleiman Y, Aliyu N, Yusuf J, Mendelsohn L, Kato GJ, Gladwin MT. Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria American Journal of Hematology. 83: 485-490. PMID 18306362 DOI: 10.1002/Ajh.21162  0.39
2008 Wood KC, Hsu LL, Gladwin MT. Sickle cell disease vasculopathy: a state of nitric oxide resistance. Free Radical Biology & Medicine. 44: 1506-28. PMID 18261470 DOI: 10.1016/J.Freeradbiomed.2008.01.008  0.434
2008 Gladwin MT. Evidence Mounts That Nitrite Contributes to Hypoxic Vasodilation in the Human Circulation Circulation. 117: 594-597. PMID 18250278 DOI: 10.1161/Circulationaha.107.753897  0.342
2008 He X, Azarov I, Jeffers A, Presley T, Richardson J, King SB, Gladwin MT, Kim-Shapiro DB. The potential of Angeli's salt to decrease nitric oxide scavenging by plasma hemoglobin. Free Radical Biology & Medicine. 44: 1420-32. PMID 18243145 DOI: 10.1016/J.Freeradbiomed.2007.12.038  0.393
2008 Gladwin MT, Patel RP. The Role of Red Blood Cells and Hemoglobin–Nitric Oxide Interactions on Blood Flow American Journal of Respiratory Cell and Molecular Biology. 38: 125-126. PMID 18195245 DOI: 10.1165/Rcmb.2007-0006Ed  0.337
2008 Lundberg JO, Weitzberg E, Gladwin MT. The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics Nature Reviews Drug Discovery. 7: 156-167. PMID 18167491 DOI: 10.1038/Nrd2466  0.334
2008 Gladwin MT, Kato GJ. Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens! Haematologica. 93: 1-3. PMID 18166776 DOI: 10.3324/Haematol.12318  0.371
2008 Aliyu ZY, Kato GJ, Taylor J, Babadoko A, Mamman AI, Gordeuk VR, Gladwin MT. Sickle cell disease and pulmonary hypertension in Africa: a global perspective and review of epidemiology, pathophysiology, and management. American Journal of Hematology. 83: 63-70. PMID 17910044 DOI: 10.1002/Ajh.21057  0.384
2008 Taylor JG, Woods GM, Machado R, Kato GJ, Gladwin MT. Severe pulmonary hypertension in an adolescent with sickle cell disease. American Journal of Hematology. 83: 71-2. PMID 17726682 DOI: 10.1002/Ajh.21039  0.355
2008 Taylor VI JG, Ackah D, Cobb C, Orr N, Percy MJ, Sachdev V, Machado R, Castro O, Kato GJ, Chanock SJ, Gladwin MT. Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease American Journal of Hematology. 83: 6-14. PMID 17724704 DOI: 10.1002/Ajh.21035  0.379
2008 Gordeuk VR, Sachdev V, Taylor JG, Gladwin MT, Kato G, Castro OL. Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency American Journal of Hematology. 83: 15-18. PMID 17696198 DOI: 10.1002/Ajh.21016  0.395
2008 Hill A, Rother RP, Wang X, Sapsford RJ, Collinson PO, Gaze DC, Morris SM, Scally A, Quinn-Senger K, Richards SJ, Bessler M, Kelly R, Hillmen P, Gladwin M. Eculizumab Reduces Pulmonary Hypertension through Inhibition of Hemolysis-Associated Nitric Oxide Consumption in Patients with Paroxysmal Nocturnal Hemoglobinuria Blood. 112: 486-486. DOI: 10.1182/Blood.V112.11.486.486  0.405
2008 Wood KC, Liu VB, Noguchi A, Wang X, Raghavachari N, Gladwin MT. Blood Cell Versus Vascular Endothelial Cell Contributions to Nitrite Homeostasis and Blood Pressure Regulation Blood. 112: 4601-4601. DOI: 10.1182/Blood.V112.11.4601.4601  0.374
2008 Krajewski ML, Kim JA, Mendelsohn LG, Williams CB, Gladwin MT, Kato GJ. Nitric Oxide-Dependent Blood Flow in Patients with Sickle Cell Disease Is Reflected by the Reactive Hyperemia-Peripheral Arterial Tonometry Index Blood. 112: 2486-2486. DOI: 10.1182/Blood.V112.11.2486.2486  0.368
2008 Niu X, Nouraie M, Minniti C, Sable C, Campbell A, Rana SR, Kato GJ, Gladwin M, Castro O, Ammosova T, Nekhai S, Gordeuk VR. Correlations Between Cytokines and Elevated Tricuspid Regurgitant Jet Velocity in Children and Adolescents with Sickle Cell Disease Blood. 112: 2484-2484. DOI: 10.1182/Blood.V112.11.2484.2484  0.382
2008 Nouraie M, Minniti C, Sable C, Campbell AD, Rana SR, Ensing G, Dham N, Onyekwere OC, Darbari DS, Kato GJ, Gladwin M, Castro O, Gordeuk VR. Association of Hemolysis with Clinical Manifestations of Sickle Cell Disease Blood. 112: 2482-2482. DOI: 10.1182/Blood.V112.11.2482.2482  0.387
2008 Presley T, Bain L, Ballas S, Nichols J, Sabio H, Gladwin M, Kato GJ, Kim-Shapiro D. The Mechanism of Hemolysis in Sickle Cell Anemia. Blood. 112: 1439-1439. DOI: 10.1182/Blood.V112.11.1439.1439  0.313
2008 Campbell AD, Minniti C, Rana SR, Onyekwere OC, Nouraie M, Arteta M, Sable C, Ensing G, Dham N, Darbari DS, Luchtman-Jones L, Kato GJ, Gladwin M, Castro O, Gordeuk VR. Oxygen Desaturation at Rest and after Exercise in Pediatric Sickle Cell Disease Patients: Correlations with Hemolysis and Elevated Tricuspid Regurgitant Jet Velocity. Blood. 112: 1423-1423. DOI: 10.1182/Blood.V112.11.1423.1423  0.361
2008 Lundberg JO, Weitzberg E, Gladwin MT. Downsides to the nitrate–nitrite–nitric oxide pathway in physiology and therapeutics? Reply from Lundberg, Weitzberg and Gladwin Nature Reviews Drug Discovery. 7: 710-710. DOI: 10.1038/Nrd2466-C2  0.307
2008 Zuckerbraun B, Choi A, Shiva S, Gladwin M. QS3. Low Dose Nebulized Nitrite Prevents or Reverses Pulmonary Hypertension and Is Dependent on Xanthine Oxidoreductase Journal of Surgical Research. 144: 271-272. DOI: 10.1016/J.Jss.2007.12.240  0.308
2007 Wu CJ, Gladwin M, Tisdale J, Hsieh M, Law T, Biernacki M, Rogers S, Wang X, Walters M, Zahrieh D, Antin JH, Ritz J, Krishnamurti L. Mixed haematopoietic chimerism for sickle cell disease prevents intravascular haemolysis. British Journal of Haematology. 139: 504-7. PMID 17910640 DOI: 10.1111/J.1365-2141.2007.06803.X  0.345
2007 Dejam A, Hunter CJ, Tremonti C, Pluta RM, Hon YY, Grimes G, Partovi K, Pelletier MM, Oldfield EH, Cannon RO, Schechter AN, Gladwin MT. Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation. 116: 1821-31. PMID 17893272 DOI: 10.1161/Circulationaha.107.712133  0.509
2007 True AL, Olive M, Boehm M, San H, Westrick RJ, Raghavachari N, Xu X, Lynn EG, Sack MN, Munson PJ, Gladwin MT, Nabel EG. Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide. Circulation Research. 101: 893-901. PMID 17885218 DOI: 10.1161/Circresaha.107.158998  0.354
2007 Isbell TS, Gladwin MT, Patel RP. Hemoglobin oxygen fractional saturation regulates nitrite-dependent vasodilation of aortic ring bioassays. American Journal of Physiology-Heart and Circulatory Physiology. 293. PMID 17766472 DOI: 10.1152/Ajpheart.00759.2007  0.32
2007 Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor JG, Kato GJ, Gladwin MT, Steinberg MH. A network model to predict the risk of death in sickle cell disease. Blood. 110: 2727-35. PMID 17600133 DOI: 10.1182/Blood-2007-04-084921  0.332
2007 Dezfulian C, Raat N, Shiva S, Gladwin MT. Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics Cardiovascular Research. 75: 327-338. PMID 17568573 DOI: 10.1016/J.Cardiores.2007.05.001  0.337
2007 Paul JD, Powell TM, Thompson M, Benjamin M, Rodrigo M, Carlow A, Annavajjhala V, Shiva S, Dejam A, Gladwin MT, McCoy JP, Zalos G, Press B, Murphy M, Hill JM, et al. Endothelial progenitor cell mobilization and increased intravascular nitric oxide in patients undergoing cardiac rehabilitation. Journal of Cardiopulmonary Rehabilitation and Prevention. 27: 65-73. PMID 17558240 DOI: 10.1097/01.Hcr.0000265031.10145.50  0.39
2007 Villagra J, Shiva S, Hunter LA, Machado RF, Gladwin MT, Kato GJ. Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin Blood. 110: 2166-2172. PMID 17536019 DOI: 10.1182/Blood-2006-12-061697  0.394
2007 Kato GJ, Onyekwere OC, Gladwin MT. PULMONARY HYPERTENSION IN SICKLE CELL DISEASE: Relevance to Children Pediatric Hematology and Oncology. 24: 159-170. PMID 17454785 DOI: 10.1080/08880010601185892  0.387
2007 Dejam A, Hunter CJ, Gladwin MT. Effects of dietary nitrate on blood pressure. The New England Journal of Medicine. 356. PMID 17429097 DOI: 10.1056/Nejmc070163  0.375
2007 Anthi A, Machado RF, Jison ML, Taveira-Dasilva AM, Rubin LJ, Hunter L, Hunter CJ, Coles W, Nichols J, Avila NA, Sachdev V, Chen CC, Gladwin MT. Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. 175: 1272-9. PMID 17379852 DOI: 10.1164/Rccm.200610-1498Oc  0.367
2007 Raghavachari N, Xu X, Harris A, Villagra J, Logun C, Barb J, Solomon MA, Suffredini AF, Danner RL, Kato G, Munson PJ, Morris SM, Gladwin MT. Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation. 115: 1551-62. PMID 17353439 DOI: 10.1161/Circulationaha.106.658641  0.353
2007 Grubina R, Huang Z, Shiva S, Joshi MS, Azarov I, Basu S, Ringwood LA, Jiang A, Hogg N, Kim-Shapiro DB, Gladwin MT. Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin. The Journal of Biological Chemistry. 282: 12916-27. PMID 17322300 DOI: 10.1074/Jbc.M700546200  0.326
2007 Shiva S, Huang Z, Grubina R, Sun J, Ringwood LA, MacArthur PH, Xu X, Murphy E, Darley-Usmar VM, Gladwin MT. Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circulation Research. 100: 654-61. PMID 17293481 DOI: 10.1161/01.Res.0000260171.52224.6B  0.331
2007 Sachdev V, Machado RF, Shizukuda Y, Rao YN, Sidenko S, Ernst I, St Peter M, Coles WA, Rosing DR, Blackwelder WC, Castro O, Kato GJ, Gladwin MT. Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease. Journal of the American College of Cardiology. 49: 472-9. PMID 17258093 DOI: 10.1016/J.Jacc.2006.09.038  0.37
2007 Hsu LL, Champion HC, Campbell-Lee SA, Bivalacqua TJ, Manci EA, Diwan BA, Schimel DM, Cochard AE, Wang X, Schechter AN, Noguchi CT, Gladwin MT. Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood. 109: 3088-98. PMID 17158223 DOI: 10.1182/Blood-2006-08-039438  0.584
2007 Machado RF, Mack AK, Martyr S, Barnett C, Macarthur P, Sachdev V, Ernst I, Hunter LA, Coles WA, Nichols JP, Kato GJ, Gladwin MT. Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease. British Journal of Haematology. 136: 319-25. PMID 17156401 DOI: 10.1111/J.1365-2141.2006.06417.X  0.397
2007 Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes Blood Reviews. 21: 37-47. PMID 17084951 DOI: 10.1016/J.Blre.2006.07.001  0.393
2007 Cuttica MJ, Anderson K, Barnett CF, Shlobin OA, Ahmad S, Barnett S, Machado R, Gladwin M, Nathan SD. Prevalence And Impact Of Pulmonary Hypertension In Patients With Chronic Obstructive Pulmonary Disease (Copd) Listed For Lung Transplantation Chest. 132: 621. DOI: 10.1378/Chest.132.4_Meetingabstracts.621A  0.321
2007 Hsieh MM, Link B, Machado R, Kato G, Gladwin M, Tisdale JF. Improvement in Hemolytic Parameters and Tricuspid Regurgitant Jet Velocity (TRV) Following Non-Myeloablative Allogeneic Stem Cell Transplantation (allo-SCT) in Adults with Severe Sickle Cell Disease (SCD). Blood. 110: 843-843. DOI: 10.1182/Blood.V110.11.843.843  0.381
2007 Hsu LL, Shiva S, Noguchi A, Curtis E, MacArthur P, Raat NJH, Diwan BA, Schechter AN, Noguchi CT, Gladwin MT. Depletion and Restoration of the Intravascular Nitrite (NO2-) Reserve Modulate Susceptibility to Liver Vaso-Occlusive Infarction in Sickle Cell Transgenic Mice. Blood. 110: 841-841. DOI: 10.1182/Blood.V110.11.841.841  0.541
2007 Aliyu ZY, Vandana S, Mamman AI, Babadoko A, Akpanpe P, Attah E, Suleiman Y, Aliyu N, Yusuf J, Mendelsohn L, Coles W, Danbauchi S, Taylor J, Castro O, Gordeuk VR, ... ... Gladwin MT, et al. Pulmonary Hypertension in Adults and Children with Sickle Cell Disease in Nigeria: Prevalence, Clinical Characteristics and Role of Endemic Tropical Infections. Blood. 110: 3793-3793. DOI: 10.1182/Blood.V110.11.3793.3793  0.403
2007 Kim-Shapiro DB, He X, Azarov I, Richardson J, King SB, Gladwin MT. Potential of Angeli’s Salt To Reduce Nitric Oxide Scavenging in Hemolysis. Blood. 110: 3788-3788. DOI: 10.1182/Blood.V110.11.3788.3788  0.384
2007 Little JA, Hauser KP, Martyr SE, Kato GJ, Machado R, Castro O, Taylor J, Gladwin MT. Phosphodiesterase Inhibition Increases Fetal Hemoglobin in Sickle Cell Disease; L-Arginine Supplementation Does Not. Blood. 110: 3396-3396. DOI: 10.1182/Blood.V110.11.3396.3396  0.623
2007 Campbell AD, Minniti C, Sable C, Ensing G, Dham N, Rana S, Darbari D, Onyekwere O, Kato GJ, Gladwin MT, Castro O, Gordeuk V. Prospective Evaluation of the Prevalence of Elevated Tricuspid Regurgitant Jet Velocity and Associated Clinical and Echocardiographic Factors in Children and Adolescents with Sickle Cell Disease. Blood. 110: 3388-3388. DOI: 10.1182/Blood.V110.11.3388.3388  0.36
2007 Arteta M, Campbell AD, Minniti C, Ensing G, Sable C, Rana S, Darbari D, Onyinye O, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR. Pulmonary Function Tests and Their Correlation with Tricuspid Regurgitant Jet Velocity in Pediatric Sickle Cell Disease Patients. Blood. 110: 2262-2262. DOI: 10.1182/Blood.V110.11.2262.2262  0.332
2007 Kato GJ, Cho CS, Yang SH, Bae SW, Lee JS, Gladwin MT, Rhee SG. Low Erythrocytic Glutathione Peroxidase-1 Activity Correlates with Hemolytic Rate in Patients with Sickle Cell Disease and Is Elevated on Hydroxyurea. Blood. 110: 2253-2253. DOI: 10.1182/Blood.V110.11.2253.2253  0.366
2006 Dias-Junior CAC, Gladwin MT, Tanus-Santos JE. Low-dose intravenous nitrite improves hemodynamics in a canine model of acute pulmonary thromboembolism. Free Radical Biology and Medicine. 41: 1764-1770. PMID 17157179 DOI: 10.1016/J.Freeradbiomed.2006.08.022  0.383
2006 Gladwin MT. Role of the red blood cell in nitric oxide homeostasis and hypoxic vasodilation. Advances in Experimental Medicine and Biology. 588: 189-205. PMID 17089890 DOI: 10.1007/978-0-387-34817-9_17  0.41
2006 Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, Long CS, Rubin LJ, Smart FW, Suzuki YJ, Gladwin M, Denholm EM, Gail DB. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation. 114: 1883-91. PMID 17060398 DOI: 10.1161/Circulationaha.106.632208  0.31
2006 Jeffers A, Gladwin MT, Kim-Shapiro DB. Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias. Free Radical Biology & Medicine. 41: 1557-65. PMID 17045924 DOI: 10.1016/J.Freeradbiomed.2006.08.017  0.403
2006 Dezfulian C, Raat NJH, Gladwin MT. A pharmacogenomic study of atorvastatin effects on eNOS activity: do "statins" modulate blood nitrite levels and intravascular oxidant stress in susceptible individuals? Free Radical Biology and Medicine. 41: 1041-1043. PMID 16962928 DOI: 10.1016/J.Freeradbiomed.2006.05.034  0.323
2006 Gladwin MT. Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome Journal of Clinical Investigation. 116: 2330-2332. PMID 16955136 DOI: 10.1172/Jci29807  0.346
2006 Shiva S, Wang X, Ringwood LA, Xu X, Yuditskaya S, Annavajjhala V, Miyajima H, Hogg N, Harris ZL, Gladwin MT. Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis. Nature Chemical Biology. 2: 486-93. PMID 16906150 DOI: 10.1038/Nchembio813  0.331
2006 Little JA, McGowan VR, Kato GJ, Partovi KS, Feld JJ, Maric I, Martyr S, Taylor JG, Machado RF, Heller T, Castro O, Gladwin MT. Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. Haematologica. 91: 1076-83. PMID 16885048 DOI: 10.3324/%%X  0.628
2006 Pelletier MM, Kleinbongard P, Ringwood L, Hito R, Hunter CJ, Schechter AN, Gladwin MT, Dejam A. The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions. Free Radical Biology & Medicine. 41: 541-8. PMID 16863986 DOI: 10.1016/J.Freeradbiomed.2006.05.001  0.537
2006 Machado RF, Anthi A, Steinberg MH, Bonds D, Sachdev V, Kato GJ, Taveira-DaSilva AM, Ballas SK, Blackwelder W, Xu X, Hunter L, Barton B, Waclawiw M, Castro O, Gladwin MT, et al. N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. Jama. 296: 310-8. PMID 16849664 DOI: 10.1001/Jama.296.3.310  0.378
2006 Wang X, Bryan NS, MacArthur PH, Rodriguez J, Gladwin MT, Feelisch M. Measurement of Nitric Oxide Levels in the Red Cell VALIDATION OF TRI-IODIDE-BASED CHEMILUMINESCENCE WITH ACID-SULFANILAMIDE PRETREATMENT Journal of Biological Chemistry. 281: 26994-27002. PMID 16845122 DOI: 10.1074/Jbc.M603953200  0.325
2006 Gladwin MT, Raat NJ, Shiva S, Dezfulian C, Hogg N, Kim-Shapiro DB, Patel RP. Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. American Journal of Physiology. Heart and Circulatory Physiology. 291: H2026-35. PMID 16798825 DOI: 10.1152/Ajpheart.00407.2006  0.348
2006 Holly MK, Dear JW, Hu X, Schechter AN, Gladwin MT, Hewitt SM, Yuen PST, Star RA. Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure Kidney International. 70: 496-506. PMID 16760904 DOI: 10.1038/Sj.Ki.5001575  0.471
2006 Kato GJ, Hsieh M, Machado R, Taylor J, Little J, Butman JA, Lehky T, Tisdale J, Gladwin MT. Cerebrovascular disease associated with sickle cell pulmonary hypertension. American Journal of Hematology. 81: 503-10. PMID 16755569 DOI: 10.1002/Ajh.20642  0.66
2006 Grubb JR, Dejam A, Voell J, Blackwelder WC, Sklar PA, Kovacs JA, Cannon RO, Masur H, Gladwin MT. Lopinavir-ritonavir: effects on endothelial cell function in healthy subjects. The Journal of Infectious Diseases. 193: 1516-9. PMID 16652279 DOI: 10.1086/503807  0.331
2006 Kim-Shapiro DB, Schechter AN, Gladwin MT. Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 697-705. PMID 16424350 DOI: 10.1161/01.Atv.0000204350.44226.9A  0.574
2006 Kato GJ, McGowan V, Machado RF, Little JA, Taylor J, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM, Gladwin MT. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood. 107: 2279-85. PMID 16291595 DOI: 10.1182/Blood-2005-06-2373  0.665
2006 Crawford JH, Isbell TS, Huang Z, Shiva S, Chacko BK, Schechter AN, Darley-Usmar VM, Kerby JD, Lang JD, Kraus D, Ho C, Gladwin MT, Patel RP. Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood. 107: 566-74. PMID 16195332 DOI: 10.1182/Blood-2005-07-2668  0.564
2006 Hill A, Reid SA, Rother RP, Gladwin MT, Collinson PO, Gaze DC, Lowe A, Guthrie A, Sivananthan MU, Hillmen P. High Definition Contrast-Enhanced MR Imaging in Paroxysmal Nocturnal Hemoglobinuria (PNH) Suggests a High Frequency of Subclinical Thrombosis. Blood. 108: 979-979. DOI: 10.1182/Blood.V108.11.979.979  0.347
2006 Taylor JG, Nolan VG, Kato GJ, Gladwin M, Steinberg MH. The Hyperhemolysis Phenotype in Sickle Cell Anemia: Increased Risk of Leg Ulcers, Priapism, Pulmonary Hypertension and Death with Decreased Risk of Vasoocclusive Events. Blood. 108: 787-787. DOI: 10.1182/Blood.V108.11.787.787  0.404
2006 Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor JG, Kato GJ, Gladwin MT, Steinberg MH. Severity of Sickle Cell Disease: Modeling Interrelationships among Hemolysis, Pulmonary Hypertension and Risk of Death. Blood. 108: 786-786. DOI: 10.1182/Blood.V108.11.786.786  0.349
2006 Basu S, Huang J, Huang Z, Jeffers A, Jiang A, He X, Azarov I, Seibert R, Patel RP, Hogg N, King B, Gladwin MT, Kim-Shapiro D. Formation of Nitroso Compounds in the Reaction of Nitrite and Hemoglobin. Blood. 108: 1565-1565. DOI: 10.1182/Blood.V108.11.1565.1565  0.339
2006 Raghavachari N, Xu X, Villagra J, Kato G, Munson PJ, Morris S, Gladwin MT. Amplified Expression Profiling of Platelet Transcriptome Reveals Global Activation of Arginine Metabolic Pathways in Patients with Sickle Cell Disease. Blood. 108: 1536-1536. DOI: 10.1182/Blood.V108.11.1536.1536  0.327
2006 Villagra JD, Nichols JT, Gladwin MT, Kato GJ. Platelets from Patients with Sickle Cell Disease and Pulmonary Arterial Hypertension Are Hypersensitive to Agonist-Induced Activation. Blood. 108: 1239-1239. DOI: 10.1182/Blood.V108.11.1239.1239  0.382
2006 Jeffers A, Gladwin M, Kim-Shapiro D. Computational Modeling of Nitric Oxide Bioavailability in Hemolytic Anemias. Blood. 108: 1209-1209. DOI: 10.1182/Blood.V108.11.1209.1209  0.387
2006 Morris CR, Suh J, Vichinsky EP, Klings ES, Steinberg MH, Shigenaga M, Ames BN, Gladwin MT, Kato GJ. Oral Arginine Increases Erythrocyte Glutathione Levels in Sickle Cell Disease: Implications for Pulmonary Hypertension. Blood. 108: 1208-1208. DOI: 10.1182/Blood.V108.11.1208.1208  0.394
2006 Kato GJ, Zeneng W, Taylor JG, Machado RF, Blackwelder WC, Gladwin MT, Hazen SL. Arginine Metabolite Profiling in Sickle Cell Disease: Abnormal Levels and Correlations with Pulmonary Hypertension, Desaturation, Hemolysis and Organ Dysfunction. Blood. 108: 1205-1205. DOI: 10.1182/Blood.V108.11.1205.1205  0.406
2006 Gladwin MT. Does eNOS stand for erythrocytic NO synthase Blood. 107: 2595-2596. DOI: 10.1182/Blood-2006-01-0210  0.335
2006 Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR, Feelisch M, et al. Correction: Corrigendum: The emerging biology of the nitrite anion Nature Chemical Biology. 2: 110-110. DOI: 10.1038/Nchembio0206-110  0.478
2006 Mollen K, Choi A, Mathier M, Ifedigbo E, Gladwin M, Zuckerbraun B. Inhaled nitrite treats experimental pulmonary arterial hypertension Journal of the American College of Surgeons. 203: S53. DOI: 10.1016/J.Jamcollsurg.2006.05.136  0.354
2005 Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR, Feelisch M, et al. The emerging biology of the nitrite anion. Nature Chemical Biology. 1: 308-14. PMID 16408064 DOI: 10.1038/Nchembio1105-308  0.524
2005 Gladwin MT. Nitrite as an intrinsic signaling molecule. Nature Chemical Biology. 1: 245-246. PMID 16408049 DOI: 10.1038/Nchembio1005-245  0.323
2005 Gladwin MT, Kato GJ. Cardiopulmonary Complications of Sickle Cell Disease: Role of Nitric Oxide and Hemolytic Anemia Hematology. 2005: 51-57. PMID 16304359 DOI: 10.1182/Asheducation-2005.1.51  0.43
2005 Minneci PC, Deans KJ, Zhi H, Yuen PS, Star RA, Banks SM, Schechter AN, Natanson C, Gladwin MT, Solomon SB. Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. The Journal of Clinical Investigation. 115: 3409-17. PMID 16294219 DOI: 10.1172/Jci25040  0.557
2005 Castro O, Gladwin MT. Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management. Hematology-Oncology Clinics of North America. 19: 881-896. PMID 16214649 DOI: 10.1016/J.Hoc.2005.07.007  0.373
2005 Azarov I, Huang KT, Basu S, Gladwin MT, Hogg N, Kim-Shapiro DB. Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation. The Journal of Biological Chemistry. 280: 39024-32. PMID 16186121 DOI: 10.1074/Jbc.M509045200  0.401
2005 Piknova B, Gladwin MT, Schechter AN, Hogg N. Electron paramagnetic resonance analysis of nitrosylhemoglobin in humans during NO inhalation. The Journal of Biological Chemistry. 280: 40583-8. PMID 16183646 DOI: 10.1074/Jbc.M506292200  0.52
2005 Kato GJ, Martyr S, Blackwelder WC, Nichols JS, Coles WA, Hunter LA, Brennan ML, Hazen SL, Gladwin MT. Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality. British Journal of Haematology. 130: 943-53. PMID 16156864 DOI: 10.1111/J.1365-2141.2005.05701.X  0.372
2005 Machado RF, Martyr S, Kato GJ, Barst RJ, Anthi A, Robinson MR, Hunter L, Coles W, Nichols J, Hunter C, Sachdev V, Castro O, Gladwin MT. Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension. British Journal of Haematology. 130: 445-53. PMID 16042696 DOI: 10.1111/J.1365-2141.2005.05625.X  0.365
2005 Huang Z, Shiva S, Kim-Shapiro DB, Patel RP, Ringwood LA, Irby CE, Huang KT, Ho C, Hogg N, Schechter AN, Gladwin MT. Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. The Journal of Clinical Investigation. 115: 2099-107. PMID 16041407 DOI: 10.1172/Jci24650  0.503
2005 Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. Jama. 294: 81-90. PMID 15998894 DOI: 10.1001/Jama.294.1.81  0.409
2005 Machado RF, Gladwin MT. Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension. British Journal of Haematology. 129: 449-464. PMID 15877728 DOI: 10.1111/J.1365-2141.2005.05432.X  0.393
2005 Gladwin MT. Hemoglobin as a Nitrite Reductase Regulating Red Cell–Dependent Hypoxic Vasodilation American Journal of Respiratory Cell and Molecular Biology. 32: 363-366. PMID 15837723 DOI: 10.1165/Rcmb.F294  0.308
2005 Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. Jama. 293: 1653-1662. PMID 15811985 DOI: 10.1001/Jama.293.13.1653  0.406
2005 Pluta RM, Dejam A, Grimes G, Gladwin MT, Oldfield EH. Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage Journal of the American Medical Association. 293: 1477-1484. PMID 15784871 DOI: 10.1001/Jama.293.12.1477  0.301
2005 Dejam A, Hunter CJ, Pelletier MM, Hsu LL, Machado RF, Shiva S, Power GG, Kelm M, Gladwin MT, Schechter AN. Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood. 106: 734-9. PMID 15774613 DOI: 10.1182/Blood-2005-02-0567  0.571
2005 Swenson KE, Eveland RL, Gladwin MT, Swenson ER. Nitric oxide (NO) in normal and hypoxic vascular regulation of the spiny dogfish, Squalus acanthias Journal of Experimental Zoology Part a: Comparative Experimental Biology. 303: 154-160. PMID 15662661 DOI: 10.1002/Jez.A.145  0.366
2005 Kang EM, Hsieh M, Powell JD, Link B, Donohue T, Kato G, Machado R, Gladwin M, Rodgers G, Tisdale JF. A Novel Allogeneic Transplant Conditioning Regimen Designed for Tolerance Induction in Patients with Severe Sickle Cell Disease. Blood. 106: 2994-2994. DOI: 10.1182/Blood.V106.11.5429.5429  0.339
2005 Yuditskaya S, Hoehn G, Suffredini A, Xu X, Munson P, Gladwin M, Kato GJ. Proteomic Identification of Dysregulated Apolipoprotein Expression in Pulmonary Hypertension Secondary to Sickle Cell Disease. Blood. 106: 3168-3168. DOI: 10.1182/Blood.V106.11.3168.3168  0.32
2005 Villagra JD, Machado RF, Hunter LA, Gladwin MT, Kato GJ. Platelet Activation Is Linked to the Severity of Pulmonary Hypertension in Sickle Cell Disease and Normalizes on Sildenafil Therapy. Blood. 106: 3166-3166. DOI: 10.1182/Blood.V106.11.3166.3166  0.344
2005 Castro O, Kato G, Sachdev V, Machado R, Ernst I, Coles WA, Nichols JS, Hunter LA, Gladwin MT. The Sickle Cell-Pulmonary Hypertension Screening Study: ECHO Findings at Two-Years of Follow Up. Blood. 106: 314-314. DOI: 10.1182/Blood.V106.11.314.314  0.347
2005 Piknova B, Gladwin MT, Hillery CA, Hogg N. Electron Paramagnetic Resonance Study of Cell-Free Hemoglobin in Sickle Cell Disease: Potential Antioxidant Role of Haptoglobin. Blood. 106: 2345-2345. DOI: 10.1182/Blood.V106.11.2345.2345  0.377
2005 Partovi K, Martyr S, McGowan V, Machado R, Taylor J, Kato G, Gladwin M, Little J. Early Predictors of Fetal Hemoglobin Response to Hydroxyurea in Sickle Cell Disease. Blood. 106: 2344-2344. DOI: 10.1182/Blood.V106.11.2344.2344  0.615
2005 Wu CJ, Krishnamurti L, Gladwin MT, Biernacki M, Rogers SA, Wang X, Zahrieh D, Antin JH, Ritz J. Mixed Hematopoietic Chimerism for Sickle Cell Disease Prevents Intravascular Hemolysis and Corrects Biomarkers of Endothelial Function. Blood. 106: 2333-2333. DOI: 10.1182/Blood.V106.11.2333.2333  0.346
2005 Mack AK, Machado RF, Sachdev V, Gladwin MT, Kato GJ. Sodium Nitrite Increases Regional Blood Flow in Patients with Sickle Cell Disease. Blood. 106: 2328-2328. DOI: 10.1182/Blood.V106.11.2328.2328  0.374
2005 Hsu LL, Dejam A, Pelletier M, Cochard AE, Diwan B, Gladwin M, Schechter AN, Noguchi C. Sexual Dimorphism in Whole Blood Nitrite and Susceptibility to Hypoxic Sickle Cell Vaso-Occlusive Injury in Mice. Blood. 106: 2327-2327. DOI: 10.1182/Blood.V106.11.2327.2327  0.536
2005 Hsu LL, Champion HC, Manci E, Diwan B, Schimel D, Cochard A, Wang X, Holtzclaw JD, Schechter A, Noguchi CT, Gladwin M. Spontaneous Pulmonary Hypertension in Transgenic Sickle Cell Mice - Hemodynamics and Histology Suggest Abnormal Nitric Oxide Production and Scavenging. Blood. 106: 208-208. DOI: 10.1182/Blood.V106.11.208.208  0.576
2005 Sachdev V, Machado RF, Shizukudu Y, Rao Y, Sidenko S, Ernst I, Peter MS, Coles WA, Rosing D, Blackwelder WC, Castro O, Kato GJ, Gladwin MT. Diastolic Dysfunction Is an Independent Risk Factor for Death in Patients with Sickle Cell Disease. Blood. 106: 206-206. DOI: 10.1182/Blood.V106.11.206.206  0.388
2005 Kim-Shapiro DB, Azarov I, Huang KT, Hogg N, Gladwin MT. Hematocrit and Oxygen Dependence of Nitric Oxide Scavenging by Red Blood Cells. Blood. 106: 205-205. DOI: 10.1182/Blood.V106.11.205.205  0.418
2005 Shiva S, Huang Z, Ringwood LA, Lefer DJ, Gladwin MT. Reduction of Nitrite to Nitric Oxide by Myoglobin Modulates Mitochondrial Respiration during Ischemia and Limits Reperfusion Injury. Blood. 106: 1673-1673. DOI: 10.1182/Blood.V106.11.1673.1673  0.302
2005 Hill A, Wang X, Sapsford RJ, Russell RP, Farrell AL, Jessop HA, McGawley GM, Oxborough DL, Pleasants P, Richards SJ, Arnold LM, Buchanan DM, Rollinson S, Gladwin MT, Hillmen P. Nitric Oxide Consumption and Pulmonary Hypertension in Patients with Paroxysmal Nocturnal Hemoglobinuria. Blood. 106: 1046-1046. DOI: 10.1182/Blood.V106.11.1046.1046  0.39
2005 Machado R, Steinberg M, Bonds D, Ballas S, Blackwelder W, Barton B, Waclawiw M, Castro O, Gladwin M. Natriuretic Peptide Levels Correlate with Pulmonary Pressures and Prospective Mortality in SCD: Use of This Biomarker To Identify Prevalence and Mortality of Pulmonary Hypertension in the MSH Cohort. Blood. 106: 1-1. DOI: 10.1182/Blood.V106.11.1.1  0.337
2005 Gladwin MT. Unraveling the hemolytic subphenotype of sickle cell disease Blood. 106: 2925-2926. DOI: 10.1182/Blood-2005-08-3285  0.324
2005 Morris CR, Vichinsky EP, Kato GJ, Gladwin MT, Hazen S, Morris SM. Arginine Metabolism, Pulmonary Hypertension, and Sickle Cell Disease—Reply Jama. 294: 2432-2434. DOI: 10.1001/Jama.294.19.2433-B  0.339
2004 Hunter CJ, Dejam A, Blood AB, Shields H, Kim-Shapiro DB, Machado RF, Tarekegn S, Mulla N, Hopper AO, Schechter AN, Power GG, Gladwin MT. Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nature Medicine. 10: 1122-7. PMID 15361865 DOI: 10.1038/Nm1109  0.577
2004 Kim-Shapiro DB, Patel RP, Schechter AN, Gladwin MT, Cannon RO, Hogg N. How do red blood cells dilate blood vessels?--Reply. Circulation Research. 95: e10. PMID 15297387 DOI: 10.1161/Res.95.3.E10  0.55
2004 Deem S, Kim SS, Min JH, Eveland R, Moulding J, Martyr S, Wang X, Swenson ER, Gladwin MT. Pulmonary vascular effects of red blood cells containing S-nitrosated hemoglobin American Journal of Physiology - Heart and Circulatory Physiology. 287: H2561-H2568. PMID 15297254 DOI: 10.1152/Ajpheart.00310.2004  0.406
2004 Nath KA, Katusic ZS, Gladwin MT. The Perfusion Paradox and Vascular Instability in Sickle Cell Disease Microcirculation. 11: 179-193. PMID 15280091 DOI: 10.1080/10739680490278592  0.374
2004 Wang X, Tanus-Santos JE, Reiter CD, Dejam A, Shiva S, Smith RD, Hogg N, Gladwin MT. Biological activity of nitric oxide in the plasmatic compartment. Proceedings of the National Academy of Sciences of the United States of America. 101: 11477-82. PMID 15258287 DOI: 10.1073/Pnas.0402201101  0.311
2004 Dejam A, Hunter CJ, Schechter AN, Gladwin MT. Emerging role of nitrite in human biology. Blood Cells, Molecules & Diseases. 32: 423-9. PMID 15121102 DOI: 10.1016/J.Bcmd.2004.02.002  0.551
2004 Gladwin MT, Schechter AN. NO contest: nitrite versus S-nitroso-hemoglobin. Circulation Research. 94: 851-5. PMID 15087423 DOI: 10.1161/01.Res.0000126697.64381.37  0.566
2004 Jison ML, Munson PJ, Barb JJ, Suffredini AF, Talwar S, Logun C, Raghavachari N, Beigel JH, Shelhamer JH, Danner RL, Gladwin MT. Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease Blood. 104: 270-280. PMID 15031206 DOI: 10.1182/Blood-2003-08-2760  0.398
2004 Gladwin MT, Crawford JH, Patel RP. The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation. Free Radical Biology & Medicine. 36: 707-17. PMID 14990351 DOI: 10.1016/J.Freeradbiomed.2003.11.032  0.42
2004 Gladwin MT, Sachdev V, Jison ML, Shizukuda Y, Plehn JF, Minter K, Brown B, Coles WA, Nichols JS, Ernst I, Hunter LA, Blackwelder WC, Schechter AN, Rodgers GP, Castro O, et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. The New England Journal of Medicine. 350: 886-95. PMID 14985486 DOI: 10.1056/Nejmoa035477  0.565
2004 Hasan S, Elbedawi M, Castro O, Gladwin M, Palestine A. Central retinal vein occlusion in sickle cell disease. Southern Medical Journal. 97: 202-204. PMID 14982276 DOI: 10.1097/01.Smj.0000100266.87750.F5  0.305
2004 Patel RP, Gladwin MT. Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxide. Free Radical Biology and Medicine. 36: 399-401. PMID 14975442 DOI: 10.1016/J.Freeradbiomed.2003.11.019  0.307
2004 Gladwin MT. Haldane, hot dogs, halitosis, and hypoxic vasodilation: the emerging biology of the nitrite anion Journal of Clinical Investigation. 113: 19-21. PMID 14702102 DOI: 10.1172/Jci20664  0.351
2004 Hsu LL, Gladwin M, Cui XZ, Li Y, Schechter AN, Noguchi CT, Schimel D, Diwan B, Manci EA, Eichacker PQ. Mouse Pneumonia Model of Sickle Cell Acute Chest Syndrome. Blood. 104: 3582-3582. DOI: 10.1182/Blood.V104.11.3582.3582  0.51
2004 Minneci PC, Deans KJ, Zhi H, Cushenberry K, Grant P, Banks SM, Natanson C, Gladwin MT, Solomon SB. Hemolysis-Endothelial Dysfunction Syndrome: A Novel Paradigm of Disease Mechanism. Blood. 104: 3581-3581. DOI: 10.1182/Blood.V104.11.3581.3581  0.39
2004 Kato GJ, Hunter C, Hunter L, Dejam A, Machado R, Mack K, Villagra J, Nichols J, Coles W, Sachdev V, Cannon R, Gladwin MT. Atorvastatin Therapy Restores Nitric Oxide-Dependent Vascular Responsiveness in Patients with Sickle Cell Disease. Blood. 104: 239-239. DOI: 10.1182/Blood.V104.11.239.239  0.393
2004 Dejam A, Gladwin MT, Christian HCJ, Hsu L, Grear JJ, Tarekegn S, Shruti S, Kelm M, Schechter AN. Characterization of the Distribution of Nitrite in Human Blood. Blood. 104: 238-238. DOI: 10.1182/Blood.V104.11.238.238  0.544
2004 Morris CR, Kato G, Poljakovic M, Blackwelder WC, Hazen S, Vichinsky EP, Morris SM, Gladwin MT. The Arginine-to-Ornithine Ratio: Biomarker of Arginase Activity and Predictor of Mortality in Sickle Cell Disease. Blood. 104: 237-237. DOI: 10.1182/Blood.V104.11.237.237  0.4
2004 Machado RF, Martyr SE, Anthi A, Kato GJ, Hunter LA, Coles WA, Nichols JS, Castro OL, Gladwin MT. Pulmonary Hypertension in Sickle Cell Disease: Cardiopulmonary Evaluation and Response to Chronic Phosphodiesterase 5 Inhibitor Therapy. Blood. 104: 235-235. DOI: 10.1182/Blood.V104.11.235.235  0.366
2004 Wu CJ, Gladwin MT, Krishnamurti L, Biernacki M, Rogers SA, Wang X, Antin JH, Ritz J. Mixed Chimerism Following Nonmyeloablative Stem Cell Transplantation for Sickle Cell Disease Prevents Intravascular Hemolysis and Restores Endothelial Function. Blood. 104: 1679-1679. DOI: 10.1182/Blood.V104.11.1679.1679  0.361
2004 Kato GJ, Martyr S, Machado R, Sachdev V, Ernst I, Hunter L, Coles W, Nichols J, Hunter CJ, Gladwin MT. Acute on Chronic Pulmonary Hypertension in Patients with Sickle Cell Disease. Blood. 104: 1669-1669. DOI: 10.1182/Blood.V104.11.1669.1669  0.36
2004 Shizukuda Y, Sachdev V, Ernst I, Nichols JS, Jison M, Brown B, Blackwelder W, Rodgers GP, Castro O, Ognibene FP, Plehn JP, Gladwin MT. 1172-74 Pulmonary hypertension is strongly associated with mortality in sickle cell disease: Comparison of echocardiographic outcome predictors Journal of the American College of Cardiology. 43. DOI: 10.1016/S0735-1097(04)91779-2  0.347
2003 Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO, ... Gladwin MT, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nature Medicine. 9: 1498-505. PMID 14595407 DOI: 10.1038/Nm954  0.572
2003 Xu X, Cho M, Spencer NY, Patel N, Huang Z, Shields H, King SB, Gladwin MT, Hogg N, Kim-Shapiro DB. Measurements of nitric oxide on the heme iron and beta-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation. Proceedings of the National Academy of Sciences of the United States of America. 100: 11303-8. PMID 14500899 DOI: 10.1073/Pnas.2033883100  0.342
2003 Jison ML, Gladwin MT. Hemolytic anemia-associated pulmonary hypertension of sickle cell disease and the nitric oxide/arginine pathway. American Journal of Respiratory and Critical Care Medicine. 168: 3-4. PMID 12826592 DOI: 10.1164/Rccm.2304002  0.419
2003 Zuzak KJ, Gladwin MT, Cannon RO, Levin IW. Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide. American Journal of Physiology. Heart and Circulatory Physiology. 285: H1183-9. PMID 12791593 DOI: 10.1152/Ajpheart.00243.2003  0.342
2003 Gladwin MT, Lancaster JR, Freeman BA, Schechter AN. Nitric oxide's reactions with hemoglobin: a view through the SNO-storm. Nature Medicine. 9: 496-500. PMID 12724752 DOI: 10.1038/Nm0503-496  0.557
2003 Schechter AN, Gladwin MT. Hemoglobin and the paracrine and endocrine functions of nitric oxide. The New England Journal of Medicine. 348: 1483-5. PMID 12686706 DOI: 10.1056/Nejmcibr023045  0.539
2003 Reiter CD, Gladwin MT. An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy. Current Opinion in Hematology. 10: 99-107. PMID 12579034 DOI: 10.1097/00062752-200303000-00001  0.383
2003 Gladwin MT, Schechter AN, Ognibene FP, Coles WA, Reiter CD, Schenke WH, Csako G, Waclawiw MA, Panza JA, Cannon RO. Divergent nitric oxide bioavailability in men and women with sickle cell disease. Circulation. 107: 271-8. PMID 12538427 DOI: 10.1161/01.Cir.0000044943.12533.A8  0.552
2003 Cokic VP, Smith RD, Beleslin-Cokic BB, Njoroge JM, Miller JL, Gladwin MT, Schechter AN. Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. The Journal of Clinical Investigation. 111: 231-9. PMID 12531879 DOI: 10.1172/Jci16672  0.567
2002 Nanavaty UB, Pawliczak R, Doniger J, Gladwin MT, Cowan MJ, Logun C, Shelhamer JH. Oxidant-induced cell death in respiratory epithelial cells is due to DNA damage and loss of ATP Experimental Lung Research. 28: 591-607. PMID 12490035 DOI: 10.1080/01902140260426715  0.33
2002 Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO, Schechter AN, Gladwin MT. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nature Medicine. 8: 1383-9. PMID 12426562 DOI: 10.1038/Nm799  0.571
2002 Deem S, Kim JU, Manjula BN, Acharya AS, Kerr ME, Patel RP, Gladwin MT, Swenson ER. Effects of S-nitrosation and cross-linking of hemoglobin on hypoxic pulmonary vasoconstriction in isolated rat lungs Circulation Research. 91: 626-632. PMID 12364391 DOI: 10.1161/01.Res.0000036268.47509.02  0.345
2002 Xu X, Lockamy VL, Chen K, Huang Z, Shields H, King SB, Ballas SK, Nichols JS, Gladwin MT, Noguchi CT, Schechter AN, Kim-Shapiro DB. Effects of iron nitrosylation on sickle cell hemoglobin solubility. The Journal of Biological Chemistry. 277: 36787-92. PMID 12138112 DOI: 10.1074/Jbc.M205350200  0.553
2002 Gladwin MT, Wang X, Reiter CD, Yang BK, Vivas EX, Bonaventura C, Schechter AN. S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function. The Journal of Biological Chemistry. 277: 27818-28. PMID 12023289 DOI: 10.1074/Jbc.M203236200  0.545
2002 Schechter AN, Gladwin MT, Cannon RO. NO solutions? The Journal of Clinical Investigation. 109: 1149-51. PMID 11994403 DOI: 10.1172/JCI15637  0.346
2002 Gladwin MT, Shelhamer JH, Ognibene FP, Pease-Fye ME, Nichols JS, Link B, Patel DB, Jankowski MA, Pannell LK, Schechter AN, Rodgers GP. Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease. British Journal of Haematology. 116: 436-44. PMID 11841449 DOI: 10.1046/J.1365-2141.2002.03274.X  0.581
2002 Deem S, Kim SS, Eveland R, Swenson ER, Gladwin MT. Effect of Red Blood Cells Containing S-Nitrosated Hemoglobin on Hypoxic Pulmonary Vasoconstriction: [2002][A-1302] Anesthesiology. 96. DOI: 10.1097/00000542-200209002-01302  0.38
2001 Noguchi CT, Gladwin M, Diwan B, Merciris P, Smith R, Yu X, Buzard G, Fitzhugh A, Keefer LK, Schechter AN, Mohandas N. Pathophysiology of a sickle cell trait mouse model: Human αβS transgenes with one mouse β-globin allele Blood Cells, Molecules, and Diseases. 27: 971-977. PMID 11831863 DOI: 10.1006/Bcmd.2001.0469  0.511
2001 Aslan M, Ryan TM, Adler B, Townes TM, Parks DA, Thompson JA, Tousson A, Gladwin MT, Patel RP, Tarpey MM, Batinic-Haberle I, White CR, Freeman BA. Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 15215-20. PMID 11752464 DOI: 10.1073/Pnas.221292098  0.351
2001 Zuzak KJ, Schaeberle MD, Gladwin MT, Cannon RO, Levin IW. Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique. Circulation. 104: 2905-10. PMID 11739304 DOI: 10.1161/Hc4901.100525  0.334
2001 Minter KR, Gladwin MT. Pulmonary complications of sickle cell anemia. A need for increased recognition, treatment, and research. American Journal of Respiratory and Critical Care Medicine. 164: 2016-2019. PMID 11739128 DOI: 10.1164/Ajrccm.164.11.2104101  0.37
2001 Gladwin MT, Ognibene FP, Shelhamer JH, Pease-Fye ME, Noguchi CT, Rodgers GP, Schechter AN. Nitric oxide transport on sickle cell hemoglobin: Where does it bind? Free Radical Research. 35: 175-180. PMID 11697198 DOI: 10.1080/10715760100300721  0.581
2001 Gladwin MT, Schechter AN. Nitric oxide therapy in sickle cell disease Seminars in Hematology. 38: 333-342. PMID 11605168 DOI: 10.1016/S0037-1963(01)90027-7  0.622
2001 Moore DF, Scott LT, Gladwin MT, Altarescu G, Kaneski C, Suzuki K, Pease-Fye M, Ferri R, Brady RO, Herscovitch P, Schiffmann R. Regional cerebral hyperperfusion and nitric oxide pathway dysregulation in Fabry disease: reversal by enzyme replacement therapy. Circulation. 104: 1506-12. PMID 11571244 DOI: 10.1161/Hc3801.096352  0.378
2001 Cannon RO, Schechter AN, Panza JA, Ognibene FP, Pease-Fye ME, Waclawiw MA, Shelhamer JH, Gladwin MT. Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery Journal of Clinical Investigation. 108: 279-287. PMID 11457881 DOI: 10.1172/Jci12761  0.564
2001 Deem S, Gladwin MT, Berg JT, Kerr ME, Swenson ER. Effects of S-nitrosation of hemoglobin on hypoxic pulmonary vasoconstriction and nitric oxide flux American Journal of Respiratory and Critical Care Medicine. 163: 1164-1170. PMID 11316654 DOI: 10.1164/Ajrccm.163.5.2007172  0.332
2001 Deem S, Kim J, Manjula BN, Swenson ER, Acharya AS, Gladwin MT. S-Nitrosation of Hemoglobin and Hypoxic Pulmonary Vasoconstriction Anesthesiology. 2001. DOI: 10.1097/00000542-200109001-00023  0.31
2000 Gladwin MT, Shelhamer JH, Schechter AN, Pease-Fye ME, Waclawiw MA, Panza JA, Ognibene FP, Cannon RO. Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans Proceedings of the National Academy of Sciences of the United States of America. 97: 11482-11487. PMID 11027349 DOI: 10.1073/Pnas.97.21.11482  0.557
2000 Hrinczenko BW, Alayash AI, Wink DA, Gladwin MT, Rodgers GP, Schechter AN. Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport British Journal of Haematology. 110: 412-419. PMID 10971400 DOI: 10.1046/J.1365-2141.2000.02203.X  0.588
2000 Gladwin MT, Ognibene FP, Pannell LK, Nichols JS, Pease-Fye ME, Shelhamer JH, Schechter AN. Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proceedings of the National Academy of Sciences of the United States of America. 97: 9943-8. PMID 10954746 DOI: 10.1073/Pnas.180155397  0.545
1999 Gladwin MT, Schechter AN, Shelhamer JH, Pannell LK, Conway DA, Hrinczenko BW, Nichols JS, Pease-Fye ME, Noguchi CT, Rodgers GP, Ognibene FP. Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity. The Journal of Clinical Investigation. 104: 937-45. PMID 10510334 DOI: 10.1172/Jci7637  0.583
1999 Gladwin MT, Schechter AN, Shelhamer JH, Ognibene FP. The acute chest syndrome in sickle cell disease: Possible role of nitric oxide in its pathophysiology and treatment American Journal of Respiratory and Critical Care Medicine. 159: 1368-1376. PMID 10228097 DOI: 10.1164/Ajrccm.159.5.9810094  0.542
1998 Gladwin MT, Pierson DJ. Mechanical ventilation of the patient with severe chronic obstructive pulmonary disease. Intensive Care Medicine. 24: 898-910. PMID 9803325 DOI: 10.1007/S001340050688  0.326
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