Brian B. Liau, Ph.D.

Affiliations: 
2013 Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
Organic synthesis
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Parents

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Elias James Corey research assistant Harvard
Matthew D. Shair grad student 2013 Harvard
 (Total syntheses of fastigiatine and the hibarimicin aglycons.)
Bradley E. Bernstein post-doc Harvard Medical School (Cell Biology Tree)
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Publications

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Waterbury AL, Caroli J, Zhang O, et al. (2025) Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nature Communications. 16: 3156
Xie X, Zhang O, Yeo MJR, et al. (2025) Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations. Nature
Yeo MJR, Zhang O, Xie X, et al. (2025) UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Nature
Yeo MJ, Zhang O, Xie X, et al. (2024) Asymmetric Engagement of Dimeric CRL3 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes. Biorxiv : the Preprint Server For Biology
Xie X, Zhang O, Yeo MJR, et al. (2024) KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes. Biorxiv : the Preprint Server For Biology
Ngan KC, Hoenig SM, Kwok HS, et al. (2023) Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery. Elife. 12
Najm FJ, DeWeirdt P, Moore MM, et al. (2023) Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature Communications. 14: 448
Gosavi PM, Ngan KC, Yeo MJR, et al. (2022) Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders. Acs Central Science. 8: 417-429
Kato S, Weng QY, Insco ML, et al. (2020) Gain-of-function genetic alterations of G9a drive oncogenesis. Cancer Discovery
Siegenfeld AP, Lee C, Liau BB. (2019) Taking a STAP at Core Promoter-Transcriptional Cofactor Specificity. Biochemistry
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