Brian B. Liau, Ph.D.
Affiliations: | 2013 | Chemistry and Chemical Biology | Harvard University, Cambridge, MA, United States |
Area:
Organic synthesisGoogle:
"Brian Liau"Mean distance: 7.73
Parents
Sign in to add mentorElias James Corey | research assistant | Harvard | ||
Matthew D. Shair | grad student | 2013 | Harvard | |
(Total syntheses of fastigiatine and the hibarimicin aglycons.) | ||||
Bradley E. Bernstein | post-doc | Harvard Medical School (Cell Biology Tree) |
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Publications
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Waterbury AL, Caroli J, Zhang O, et al. (2025) Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nature Communications. 16: 3156 |
Xie X, Zhang O, Yeo MJR, et al. (2025) Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations. Nature |
Yeo MJR, Zhang O, Xie X, et al. (2025) UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Nature |
Yeo MJ, Zhang O, Xie X, et al. (2024) Asymmetric Engagement of Dimeric CRL3 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes. Biorxiv : the Preprint Server For Biology |
Xie X, Zhang O, Yeo MJR, et al. (2024) KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes. Biorxiv : the Preprint Server For Biology |
Ngan KC, Hoenig SM, Kwok HS, et al. (2023) Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery. Elife. 12 |
Najm FJ, DeWeirdt P, Moore MM, et al. (2023) Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature Communications. 14: 448 |
Gosavi PM, Ngan KC, Yeo MJR, et al. (2022) Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders. Acs Central Science. 8: 417-429 |
Kato S, Weng QY, Insco ML, et al. (2020) Gain-of-function genetic alterations of G9a drive oncogenesis. Cancer Discovery |
Siegenfeld AP, Lee C, Liau BB. (2019) Taking a STAP at Core Promoter-Transcriptional Cofactor Specificity. Biochemistry |